{"data":[{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":148,"idioma_id":4,"titulo":"New and highly active microbial phosphotriesterase sources","resumen":"Many toxic insecticides used worldwide as well as some chemical warfare agents are phosphotriester derivatives. Therefore, detoxification of organophosphorus compounds has become the subject of many studies and in particular bioremediation, based on the phosphotriesterase catalysed hydrolysis of these compounds, has shown to be an effective and ecological methodology. In order to identify new bacterial phosphotriesterases, a simple and sensitive fluorimetric screening method on solid media was employed that allowed the selection of six strains with phosphotriesterase activity. Since pH and temperature are important parameters for bioremediation of contaminated soils and waters, the influence of these variables on the rate of the enzymatic hydrolysis was assessed. This study afforded notable results, being the most remarkable one the increased activity exhibited by Nocardia asteroides and Streptomyces setonii strains at 50°C, 7 and 30 times higher than at 30°C, respectively. Compared with the results obtained with Brevundimonas diminuta, whose activity is usually considered as reference, an increase of 26 and 75 times is observed, respectively.","palabras_clave":"BIOREMEDIATION NOCARDIA ASTEROIDES|BREVUNDIMONAS DIMINUTA|ORGANOPHOSPHORUS COMPOUNDS|PHOSPHOTRIESTERASE|STREPTOMYCES SETONII"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":232,"idioma_id":5,"titulo":"Nota editorial","resumen":"VER PDF ADJUNTO","palabras_clave":"BOLETIN|HORTICOLA|NOTA|EDITORIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":325,"idioma_id":5,"titulo":"Panorama de la Economía Internacional","resumen":"El escenario presente de la economía global se caracteriza por un crecimiento débil de los países avanzados que conjuntamente con la persistencia de precios de commodities bajos y flujos de comercio y capital, afectan el desempeño de los países en desarrollo y emergentes. La recuperación de los países desarrollados está estancada y se espera un resultado más modesto para lo que queda del año respecto de lo proyectado a principios de 2016. Por su parte, los países en desarrollo presentan una tendencia estable en el corriente año, con una tasa de crecimiento esperada de 3,5% en promedio, apenas por encima de la de 2015. La situación es heterogénea,con efectos diversos para exportadores e importadores ante la caída en los precios del petróleo y otros commodities. Según la OMC (2016a, 2016b) se prevé que el volumen de comercio mundial crezca un 2,7% en 2016,tasa levemente por debajo de la observada en 2015 (2,8%), pero casi un punto porcentual por debajo de las proyecciones para 2017 (3,6%). El nivel alcanzado en 2015 representa el cuarto año consecutivo con tasa inferior al 3%, y aproximadamente el mismo ritmo que el PIB mundial durante los últimos cinco años y por debajo de lo ocurrido en el período 1990-2008.El año 2015 presentó una importante recuperación de los flujos de inversión extranjera directa con unaumento de 38% respecto al año anterior cuyo principal factor fue dado por fusiones y adquisiciones transfronterizas como también por modificaciones en la estructura corporativa según datos publicados por UNCTAD (2016).En 2015 el PIB de la región latinoamericana mostró una reducción de 0,5%, a partir del comportamiento de la demanda interna, que se contrajo fundamentalmente por una retracción en la inversión pero también por la caída en el consumo, que no pudo ser compensada por la expansión en las exportaciones netas. En un contexto externo aún negativo, fundamentalmente por el menor dinamismo de los principales socios comerciales y de los bajos precios de los productos básicos, la evolución que tuvo la inversión en los últimos años y la retracción en el consumo son los principales factores que impactan en las economías latinoamericanas, en especial en las de América del Sur.El crecimiento en Asia en desarrollo será para 2016 y 2017 ligeramente más bajo que en 2015 (5,7% contra 5,9%, respectivamente) según la proyección realizada por el Asian Development Bank (2016). En cuanto a la economía china, el escenario esperado es de crecimiento moderado con derrames al resto de Asia. En parte se debe al cambio de una estrategia de crecimiento impulsada por la inversión y las exportaciones a otra empujada por la demanda interna y los servicios, lo cual termina afectando la estructura de importaciones. Siguiendo con la tendencia observada en los últimos años la economía se ha ralentizadopreviéndose una disminución de la tasa de crecimiento que alcanzaría un 6,3% en 2017. El desempeño económico africano resistió a la débil coyuntura mundial, los bajos precios de los commodities y las condiciones climáticas adversas en gran parte del continente, según la publicación conjunta del African Development Bank, OECD y PNUD (2016).","palabras_clave":"ECONOMÍA MUNDIAL|COMERCIO|OECD|LATINOAMÉRICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":557,"idioma_id":4,"titulo":"Anatomy  of  nasal  complex  in  the  Southern  Right  Whale,  Eubalaena  australis  (Cetacea,  Mysticeti)","resumen":"The nasal region of the skull has undergone dramatic changes during the course of cetacean evolution. In particular, mysticetes (baleen whales) conserve the nasal mammalian pattern associated with the secondary function of olfaction, and lack the sound-producing specializations present in odontocetes (toothed whales, dolphins and porpoises). To improve our understanding of the morphology of the nasal region of mysticetes, we investigate the nasal anatomy, osteology and myology of the southern right whale, Eubalaena australis, and make comparisons with other mysticetes. In E. australis external deflection surfaces around the blowholes appear to divert water off the head, and differ in appearance from those observed in balaenopterids, eschrichtiids and cetotherids. In E. australis the blowholes are placed above hypertrophied nasal soft tissues formed by fat and nasal muscles, a pattern also observed in balaenopterids (rorqual mysticetes) and a cetotherid (pygmy right whale, Caperea marginata). Blowhole movements are due to the action of five nasofacial muscles: dilator naris superficialis, dilator naris profundus, depressor alae nasi, constrictor naris, and retractor alae nasi. The dilator naris profundus found in E. australis has not been previously reported in balaenopterids. The other nasofacial muscles have a similar arrangement in balaenopterids, with minor differences. A novel structure, not reported previously in any mysticete, is the presence of a vascular tissue (rete mirabile) covering the lower nasal passage. This vascular tissue could play a role in warming inspired air, or may engorge to accommodate loss of respiratory space volume due to gas compression from increased pressure during diving.","palabras_clave":"ANATOMY|BLOWHOLE|EUBALAENA AUSTRALIS|MYSTICETE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":784,"idioma_id":4,"titulo":"ESTIMATING AND FORECASTING THE YIELD CURVE USING A MARKOV SWITCHING DYNAMIC NELSON AND SIEGEL MODEL","resumen":"Abstract  In this paper we estimate the yield curve of U.S. government bonds using a Markov switching latent variable model. We show how measures such as the level, slope, and curvature of the yield curve are a&#65533;ected by business cycle conditions. We present a switching latent model which not only seem to capture this features in sample but also performs well out of sample.","palabras_clave":"yield curve|Markov"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":811,"idioma_id":5,"titulo":"Enseñanza de la Administración: estrategias e innovación en el primer año de la Fac. de Ciencias Económicas de la UNJU","resumen":"Este trabajo tiene por objeto difundir el proyecto de investigación elevado a la SECTER y denominado ?ENSEÑANZA DE LA ADMINISTRACION: ESTRATEGIAS E INNOVACION EN EL PRIMER AÑO DE LA FACULTAD DE CIENCIAS ECONOMICAS DE LA UNJU?, el cual se inscribe en los ámbitos de la educación superior universitaria y se centrará en el proceso de enseñanza-aprendizaje en la cátedra Teoría General de la Administración, cuya ubicación curricular se encuentra en el primer año del ciclo básico común para las carreras de Contador Público y la Licenciatura en Administración de Empresas de la Facultad de Ciencias Económicas de la Universidad Nacional de Jujuy.La problemática en torno a los procesos de enseñanza-aprendizaje como las dificultades que se presentan en la práctica docente universitaria tradicionalmente presenciales, se constituyen en una cuestión prioritaria para las universidades. Ello exige la búsqueda permanente de procesos que permitan mejorar la relación docente\/alumno enmarcada en las limitaciones naturales presentadas por la masividad del régimen de ingreso irrestricto a los claustros universitarios.En este contexto el proyecto persigue como finalidad establecer estrategias innovadoras de enseñanza de la administración que se apliquen en el primer año del ciclo básico común de las carreras vigentes en la Facultad de Ciencias Económicas.Para ello, se consideró como más apropiada la utilización de una metodología cualitativa - cuantitativa que nos permitirá analizar el objeto desde una perspectiva subjetiva - objetiva.","palabras_clave":"ENSEÑANZA|APRENDIZAJE|ALUMNOS|ESTRATEGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":846,"idioma_id":4,"titulo":"Calcium supplementation for prevention of primary hypertension.","resumen":"Hypertension is a major public health problem in both the developed and the developing world increasing the risk of cardiovascular and kidney diseases. The global prevalence of hypertension and high blood pressure are estimated to be 30% and 26% respectively Kearney, 2004 and high blood pressure has been estimated to increase to 29% by the year 2025.     High blood pressure has been identified as the leading risk factor to mortality and the third leading risk factor for disease burden globally. In the year 2001, 7.6 million (13.5%) of all deaths were attributable to high blood pressure.    While the prevalence of hypertension seems to be stabilizing or decreasing in the developed world, it is increasing in developing countries. Low-income and middle-income regions contribute to 80% of the attributable burden of disease affecting the younger age groups more than in high income countries. While chronic diseases have increased in these countries, undernutrition related problems such as micronutrient deficiencies still persist leaving a double burden of disease.  These represent a challenge to develop interventions as excess and deficit nutritional problems have to be tackled within the same population and frequently within the same home.     Several studies have shown an inverse association between calcium intake and blood pressure or hypertension. The hypothesis was originated by the observation that indigenous Guatemalan women showed low figures of PE-E and a high calcium intake due to the Mayan habit of treating corn with lime water.Based on this hypothesis a series of studies have been reported mainly in pregnant women, but also in children, and young and older adults.    Due to the high frequency of hypertension, population based strategies to reduce blood pressure are more cost effective than individual strategies. Calcium supplementation or food fortification  are affordable interventions that if proven effective in reducing blood pressure, even in small levels, could have considerable impact at a population level. The effects on children and young people are of particular importance as pressure tends to track into adulthood. Williams2011    This review will explore the efficacy and safety of calcium supplementation or food fortification in reducing blood pressure and consequently in preventing hypertensive related problems in normotensive subjects of different age groups. It will look at the effect in reducing blood pressure in each population group and in preventing rather than treating hypertensive related problems. It will also provide more information of the effect of incrementing calcium intake on blood pressure of non pregnant women of reproductive age. Reviewing the effect of calcium in a normotensive population would be valuable to assess whether it could allow women to reach pregnancy with a lower range of blood pressure and a lower risk of developing pre-eclampsia or eclampsia.    As there have been some concerns about adverse effects of calcium supplementation there is a need to assess adverse effects such as renal tract stone formation, impaired absorption of other minerals and increased cardiovascular events.      Objective:To assess the efficacy and safety of calcium supplementation versus placebo or control for reducing blood pressure in normotensive subjects.    Methods: All published unpublished and ongoing trials with random allocation to dietary calcium intervention such as supplementation or food fortification versus placebo or control. Quasi-random designs were excluded.    Participants: Normotensive subjects of different age groups excluding pregnant women.    Type of interventions:Interventions will include calcium supplementation using pills, tablets or sprinkle powder or any food or beverage fortified with calcium compared to placebo or control.    Calcium fortification can include salt of calcium carbonate, sulphate, citrate, citrate malate, chloride, hydroxyapatite, phosphate, acetate, lactate, glycerophosphate, gluconate, oxide, or hydroxide. Calcium content in these salts varies from 9 to 70%. New Reference    Studies with no placebo or control will be excluded. Interventions where calcium is combined with other macro or micronutrient to assess effects of both will be excluded.","palabras_clave":"Calcium|Hypertension|Supplementation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":918,"idioma_id":5,"titulo":"Educación y terrorismo de Estado en la Argentina. La política educativa de los dinosaurios","resumen":"El presente artículo es producto y parte de una investigación desarrollada como Tesis de Doctorado. En la Tesis investigamos sobre la relación entre educación y hegemonía. Estudiamos el vínculo entre la construcción de legitimidad y consenso y la educación en un determinado momento histórico, la presidencia de Raúl Alfonsín (1983-1989), que fue el primer gobierno postdictatorial.   Si bien nuestro estudio se focalizó en la descripción y análisis de las políticas de Educación de Jóvenes y Adultos durante el gobierno de Alfonsín, específicamente el Plan Nacional de Alfabetización, pensamos que resultaba indispensable para comprender sus especificidades, referirnos a los tiempos terroríficos precedentes, en tanto y en cuanto fue durante el terrorismo de Estado que se produjo un desmantelamiento del proyecto pedagógico hegemónico civilizatorio-estatal, se fortalecieron los procesos de diferenciación educativa y se sentaron las bases para la consolidación del proyecto educativo neoliberal de las décadas siguientes.   En este sentido, en un apartado de la Tesis analizamos las características generales de la educación durante el terrorismo de Estado de modo de describir la herencia recibida, e identificamos los problemas educativos diagnosticados por distintos sectores al finalizar los años del genocidio. Este trabajo analítico es lo que aquí se presenta.","palabras_clave":"DICTADURA|HISTORIA DE LA EDUCACIÓN ARGENTINA|POLÍTICA EDUCATIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":925,"idioma_id":4,"titulo":"Disease Tolerance in Helianthus Petiolaris : A Genetic Resource for Sunfl ower Breeding","resumen":"Abstract: Argentina is a major sunfl ower producer in the world, with crop acreage of 2&#8722;2.7 million hectares in the last four years. Sunflower crop yield is often influenced by sanitary constraints, mainly fungal pathogens. Helianthus petiolaris is a wild species native to North America established in central Argentina displays a high tolerance to a number of fungal diseases and insects. Controlled crosses of this species with sunflower demonstrated that H. petiolaris constitutes a  valuable genetic variability source for sunfl ower breeding to improve tolerance to rust (Puccinia helianthi), white rust (Albugo tragopogonis), verticillium wilt (Verticillium dahliae), powdery mildew (Erisiphe sp.) and the sunfl ower moth (Rachiplusia nu). This places H. petiolaris in an outstanding position as a genetic resource since different important traits could be transferred to the crop through interspecific hybridization.","palabras_clave":"Disease tolerance|Helianthus petiolaris|Interspecific hybrids|Sunflower moth"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":956,"idioma_id":4,"titulo":"Comparison between inbreeding analyses methodologies","resumen":"Surnames are widely used in inbreeding analysis, but the validity of results has often been questioned due to the failure to comply with the prerequisites of the method. Here we analyze inbreeding in Hallstatt (Austria) between the 17th and the 19th centuries both using genealogies and surnames. The high and significant correlation of the results obtained by both methods demonstrates the validity of the use of surnames in this kind of studies. On the other hand, the inbreeding values obtained (0.24 x 10-3 in the genealogies analysis and 2.66 x 10-3 in the surnames analysis) are lower than those observed in Europe for this period and for this kind of population, demonstrating the falseness of the apparent isolation of Hallstatt?s population. The temporal trend of inbreeding in both analyses does not follow the European general pattern, but shows a maximum in 1850 with a later decrease along the second half of the 19th century. This is probably due to the high migration rate that is implied by the construction of transport infrastructures around the 1870?s.","palabras_clave":"INBREEDING|ISONIMY|GENEALOGY|POLYPHILETISM|MIGRATION|HALLSTAT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1000,"idioma_id":5,"titulo":"Sociabilidad corporativa y espacio público en Argentina a comienzos del siglo XX","resumen":"La experiencia del Primer Congreso del Comercio Argentino (1911) realizado en la ciudad de Rosario significó la más cabal expresión de la fuerza y dinamismo de los empresarios locales reunidos en torno de la Bolsa de Comercio. Por un lado esta instancia sirvió para propiciar una alternativa de discusión nacional alrededor de la resolución de  problemas y generación de instancias de acción colectiva del sector. Por otro representó la búsqueda de canales de diálogo y presión de las instancias asociativas empresariales sobre el Estado provincial y nacional, en particular sobre los poderes legislativo y judicial. Pero también fue una ejercicio fundamental de sociabilidad capaz de alimentar por un lado la trama de intereses sectoriales y por otro identificar a este evento como una empresa colectiva del espacio público rosarino. Esta artículo se detiene específicamente en el análisis de este último aspecto.","palabras_clave":"Sociabilidad|espacio público|corporaciones |centenario"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1001,"idioma_id":4,"titulo":"A polyhedral approach for the equitable coloring problem","resumen":"In this work we study the polytope associated with a 0\/1 integer programming formulation for the Equitable Coloring Problem. We find several families of valid inequalities and derive sufficient conditions in order to be facet-defining inequalities.  We also present computational evidence of the effectiveness of including these inequalities as cuts in a Branch & Cut algorithm","palabras_clave":"EQUITABLE GRAPH COLORING|INTEGER PROGRAMMING|BRANCH AND CUT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1005,"idioma_id":5,"titulo":"La enseñanza de la geografía Un desafío para América Latina","resumen":"La fructífera combinación de esfuerzos entre el CEPEIGE y el IPGH dio lugar el año 2012 a un memorable episodio: se cumplieron cuarenta versiones sucesivas del Curso Internacional de Geografía Aplicada que se realiza en la ciudad de Quito y congrega a representantes de distintos países de América. En esta ocasión, dicho curso ?habitualmente reservado a cuestiones técnicas referidas a la ordenación territorial y la geografía aplicada? trató sobre cuestiones más cercanas a la teoría, la historia del pensamiento geográfico y la educación. La orientación de este ciclo debe considerarse como una señal: América Latina crece hacia nuevos horizontes políticos, económicos e institucionales y en este camino necesita consolidar sus estudios geográficos. Para alcanzar esta meta es necesario que se desarrolle la geografía desde sus bases. Es por ello que resulta importante cubrir dos campos con criterio continental: el primero ahonda en el pensamiento teórico, como fundamento de la aplicación; el segundo discute la enseñanza de la geografía como forma de rescatar futuras mentalidades de la cantera que representan las nuevas generaciones. En esta presentación colectiva se incluyen resúmenes de los trabajos de investigación que los becarios presentaron como instancia de graduación en el curso aludido, que se denominara ?La educación y la investigación de la geografía frente a las nuevas tecnologías de manejo espacial?.","palabras_clave":"ENSEÑANZA|GEOGRAFÍA|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1062,"idioma_id":4,"titulo":"Delayed cooling or suboptimal storage temperatures reduce butterhead lettuce shelf life","resumen":"Abstract    Crated or uncrated butterhead lettuce (Lactuca sativa L.) var. Lores, responds to environmental conditions during early post-harvest, the first 24 hours after harvest. The present work examines effects of environmental conditions during early post-harvest on quality indices in refrigerated storage. Additionally, effects on shelf-life were estimated using the modified Global Stability Index methodology. Quality indices at the start of storage were higher for heads exposed to optimal conditions immediately after harvest than for heads exposed to suboptimal ones. In spite of these initial differences, changes of almost all quality indices was independent of storage condition. Similar responses were found for water content, bound and free water, ascorbic acid, total chlorophyll and overall visual quality. Changes in relative water content and mesophilic bacteria counts during refrigerated storage was a function of environmental condition during the first 24 hrs after harvest. Maintenance of optimal environmental conditions during the first hours after harvest prolonged shelf-life to 12 days compared with heads exposed to sub-optimal conditions during the early post-harvest period. These results impact marketing of the produce and support the idea that proper handling during early post-harvest diminishes quality loss and prolongs shelf-life allowing butterhead lettuce to reach more distant markets.","palabras_clave":"early postharvest|quality|cold chain|leafy vegetables"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1076,"idioma_id":4,"titulo":"Total phenolic content and antioxidant activity of different streams resulting from pilot-plant processes to obtain Amaranthus Mantegazzianus protein concentrates","resumen":"Antioxidant properties of different pilot-plant process streams to obtain Amaranthus mantegazzianus protein concentrates (APC) were evaluated. Conventional process (CP) (alkaline extraction and isoelectric precipitation) and two alternative processes (APs): (1) acid pre-treatment stage combined with isoelectric precipitation and (2) acid pre-treatment stage combined with ultrafiltration were applied at pilotplant scale to obtain APC. Methanol and water extracts of APC and other fractions obtained in the processes were evaluated by Folin?Ciocalteau method in order to determine total phenolic content and by DPPH radical scavenging activity method to determine antioxidant activity. Acid pre-treatment stage and ultrafiltration caused an effective removal of phenolic compounds yielding on the one hand APC with lower phenolic content than the ones obtained by CP. On the other hand, the acid extract and the whey obtained presented high phenolic content and antioxidant activity and could be used as additives to increased this parameters in food. Finally, evaluated processes could be used to obtain several products (concentrates, whey, extracts) with different&nbsp; henolic content and antioxidant activity suitable for different applications in food industry.","palabras_clave":"xxx"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1085,"idioma_id":5,"titulo":"PENETRACIÓN DE FOSFOMICINA EN EXPLANTES INTESTINALES","resumen":"Fosfomicina (FOS) es un antibiótico utilizado en producción porcina para el tratamiento y prevención de infecciones causadas por bacterias resistentes durante el post destete. En la dieta de los animales es frecuente encontrar antibióticos y concentraciones subtóxicas de micotoxinas como el deoxinivalenol (DON). Estos compuestos pueden establecer interacciones en el tracto intestinal y\/o modificando la penetración de FOS a los enterocitos. El objetivo de este trabajo fue desarrollar un cultivo de explantes de intestino procedentes de yeyuno de cerdos y aplicar este modelo para estudiar la penetración intracelular de FOS en presencia o ausencia de DON. El uso de explantes intestinales disminuye el sacrificio de animales por experimento y preservan la estructura histológica intestinal normal en condiciones in vitro. Los resultados mostraron que no existieron diferencias estadísticamente significativas en la concentración intracelular de FOS entre los explantes incubados con 580 ppm FOS y los explantes incubados con 580 ppm FOS y 1 ppm DON. Se obtuvo un Cmax de 12 ppm y tmax de 2 hs. Nuestro estudio demostró que solo el 2% del antibiótico se acumula intracelularmente y que la concentración intracelular de FOS no es afectada por la presencia de concentraciones subtóxicas de DON.","palabras_clave":"FOSFOMICINA|DEOXINIVALENOL|EXPLANTES INTESTINALES|CERDOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1130,"idioma_id":5,"titulo":"SENSORAMIENTO REMOTO Y MAGNETISMO APLICADO AL ESTUDIO DE TERRENOS PALEOZOICOS EN LA PRECORDILLERA OCCIDENTAL (31º20?LS), SAN JUAN, ARGENTINA.","resumen":"En el presente trabajo se realizaron cocientes de bandas y se ensayaron técnicas de clasificación supervisada y no supervisada en imágenes satelitales Landsat 7 Enhaced Thematic Mapper (ETM+), correspondientes a un sector de la Precordillera occidental argentina. Con el objetivo de arrojar luz sobre los aspectos estratigráficos y estructurales de las zonas aledañas a las nacientes del río San Juan, se aplicó el cociente de bandas RGB (7\/5, 5\/4, 3\/1). Los resultados obtenidos de la información digital sumados al control de campo permiten postular que los tonos pardos rojizos y pardos amarillentos representan niveles sedimentarios silicoclásticos, mientras que las tonalidades verde y verde claro corresponden a niveles donde predominan las rocas ígneas básicas. Por otra parte, las clasificaciones supervisadas y no-supervisadas no han aportado significativamente al presente estudio, debido a que presentan serias limitaciones para diferenciar unidades geológicas. Tal limitación, podría estar relacionada con la variabilidad espectral de las rocas del área de estudio. De manera complementaria, se estableció la trama estructural de la región mediante el procesamiento de un modelo de elevación digital (MED) del terreno, cuyos resultados permitieron interpretar la existencia de tres sistemas de fracturación, que en orden de importancia son: NO-SE, N-S y E-O. Se realizó un relevamiento de campo de las estructuras, en el cual se corroboró la veracidad de la interpretación estructural obtenida mediante el procesamiento. El estudio de la susceptibilidad magnética de las rocas proporcionó una herramienta de mapeo muy significativa para el trabajo de campo y se estableció el rango de variación de este parámetro para cada grupo litológico. El análisis conjunto de evidencias multidisciplinarias expuesto precedentemente permite ratificar que la zona es el resultado de una compleja y polifásica historia de deformación y que la estructuración moderna de la Precordillera occidental ha sido controlada por antiguos lineamientos que resultan de su compleja evolución. La aplicación de técnicas alternativas de mapeo como el procesamiento de imágenes satelitales y de modelos de elevación digital en adición al estudio de propiedades magnéticas, constituye una poderosa herramienta para utilizar en estudios geológico- estructurales de detalle.","palabras_clave":"Deledetección|DEM|Susceptibilidad Magnética"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1141,"idioma_id":5,"titulo":"Haciendo cultura en la crisis","resumen":"La reseña del libro 'revista crisis (1973-1976) antología. del intelectual comprometido al intelectual revolucionario.Presentación y selección de textos María Sonderéguer',es un intento de analizar los logros y debilidades de un libro que reúne notas, ensayos y entrevistas de una revista altamente representativa de los cruces entre política y producción cultural en la década de 1970. La autora de la antología logra reunir un conjunto de textos que ilustran de modo contundente las principales preocupaciones y discusiones que desfilaron por las páginas de crisis. Logra de este modo su principal objetivo: que la relectura de crisis sirva para repensar la cultura de su época. En el debe se pueden señalar la menor atención dada a los autores latinoamericanos, teniendo en cuenta que la revista proponía un marco continental como marco de identificación.","palabras_clave":"Cultura|Publicaciones|Izquierdas|América Latina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1161,"idioma_id":4,"titulo":"Vegetation change and land tenure in Mexico: A country-wide analysis","resumen":"There is an ongoing debate on the effect different property regimes have on the use of natural resources and land conversion (i.e., deforestation or reforestation). Much of the discussion has been centered on the  two main forms of tenure regime: common-pool system and private property. Case studies around the world have provided evidence on whether one is more effective at preventing deforestation than the other, but  there is not a clear pattern. Part of the problem is that evidence comes from theoretical models or isolated case studies instead of comparative studies across large areas. This paper helps to fill this gap by analyzing the association between land cover change (2001\u20132010) and land tenure regimes including private and two types of common-pool systems (communal and ejido) in Mexico at the municipality level. The analyses  were conducted for each of the four major biomes (i.e., moist forest, dry forest, coniferous forest, and desert) to control for differences in environmental factors. Municipalities dominated by communal land  tenure had the largest increase in woody cover (classified as >80% cover) in the moist forest, dry forest, and coniferous forest biomes, and municipalities classified as private also had an increase in woody cover,  particularly in the desert biome. In contrast, municipalities classified as ejidos (common-pool tenure system resulting from the land reform) lost woody cover mostly in moist forest and desert biomes, but gained woody cover in dry forest and coniferous forest biomes. In modeling analyses, environmental variables were the most important variables associated with woody cover change for private and most communal municipalities, while socioeconomic variables were the most important in ejido regimes. These  results highlight the importance of land tenure on land cover change, and show that differences in woody cover change between types of common-pool systems can be larger than their differences with private land tenure. During the last 10 years, virtually all deforestation has occurred in areas dominated by ejidos; in contrast, communal and private regimes seem to ameliorate the deforestation process. © 2012 Elsevier Ltd. All rights","palabras_clave":"Land use change|Mexico|Land tenure|Deforestation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1165,"idioma_id":4,"titulo":"Social Status in Early Adolescence: Influence of Academic Performance, Effortful Control, and Empathy","resumen":"In this study, a double procedure involving nominations positive\/negative) and classification prosocial behavior) was used to assign 1,422 students aged 12-14 years to five sociometric status categories: Popular-Prosocial, Rejected-Non-prosocial, Controversial, Neglected, and Average. Measures of academic performance, empathy, cognitive control, and emotional intelligence were obtained. A descriptive discriminant analysis (DDA) was also performed to verify which of these variables differed among members of the groups. Results showed that academic performance, empathic concern, and impulsivity were the variables that significantly discriminated between groups. Students in the Popular-Prosocial group had the best academic performance, high scores in empathic concern, and low impulsivity. Those in the Rejected-Nonprosocial group had the worst academic performance and low levels of empathic concern and impulsivity. Members of the Controversial group had average academic performance and empathic concern and very high impulsivity scores.","palabras_clave":"Academic performance|Cognitive control|Empathy|Sociometric studies"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1169,"idioma_id":4,"titulo":"POLYUNSATURATED FATTY ACIDS (PUFAs) AND GLIOMAS: A CRITICAL REVIEW OF EXPERIMENTAL, CLINICAL AND EPIDEMIOLOGICAL DATA.","resumen":"Essentials fatty acids (EFAs) cannot be biosynthesized by the body, they are obtained from diet. These fatty acids and their metabolites have multiple physiological functions that are altered in tumor cells due to a decreased expression of d-6 desaturase, which is an essential step in their metabolism. In this way, tumor cells would be protected from the toxic effect caused by free radicals, one helpful product of EFAs metabolism. EFAs have been proposed to have therapeutic potential in the treatment of glioblastoma. Gliomas are the most common primary tumors of the central nervous system in children and adults. High-grade gliomas remain a therapeutic challenge in neuro-oncology because there is no treatment that achieves a significant improvement in survival. Novel therapeutic strategies that use EFAs for the treatment of gliomas have been assessed in cell cultures, rodent glioma models and human patients, with encouraging results. Here we reviewed the latest progress made in the field.","palabras_clave":"essential fatty acids|gliomas treatment|central nervous system tumors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1173,"idioma_id":5,"titulo":"Programas y Proyectos","resumen":"Los Proyectos de Extensión son instrumentos de planificación con los cuales se generan procesos de educación no formal, que la Facultad de Odontología mediante los conocimientos y la capacidad de sus docentes, investigadores, alumnos y no docentes comparten con la comunidad a la cual van dirigidos.","palabras_clave":"PROGRAMAS |PROYECTOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1183,"idioma_id":4,"titulo":"Pathogen icity of phylogenetic species in the Fusarium graminearum complex on soybean seedlings in Argentina","resumen":"Pathogenicity ofphylogenetic species in the Fusarium graminearumcomplex on soybean seedlings in Argentina","palabras_clave":"FUSARIUM GRAMINEARUM|FUSARIUM MERIDIONALE|FUSARIUM CORTADERIAE|PATHOGENICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1187,"idioma_id":5,"titulo":"Agricultura prehispánica en Yasyamayo (valle de Santa María ? Tucumán ? Argentina)","resumen":"En Argentina, son escasos los trabajos científicos referentes a la actividad agrícola prehispánica y prácticamente inexistentes aquellos que la estudian desde una perspectiva geoarqueológica. El objetivo de este trabajo es determinar las alteraciones antrópicas producidas por el uso sostenido de los campos de cultivos prehispánicos tardíos, ubicados en Yasyamayo (valle de Santa María, Tucumán, Argentina), y su relación con las condiciones ambientales típicas del momento de ocupación. Para ello se utilizaron métodos provenientes de las geociencias tales como determinaciones de pH, textura, color, estructura, porcentaje de materia orgánica, fósforo orgánico, fósforo disponible, calcio, y manganeso, cobre y hierro disponibles. Como resultado pudo observarse una clara diferencia entre las tierras bajo cultivo y aquellas naturales. Incluso se pudo establecer la utilización de abono para la manutención de los campos agrícolas, en condiciones medioambientales adversas.  NOTA: EL TRABAJO ESTA ENVIADO, NO HEMOS TENIDO RESPUESTA AUN DE LA REVISTA.","palabras_clave":"Gaoarqueología|Desarrollos Regionales|Suelos|Agricultura prehispánica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1189,"idioma_id":5,"titulo":"Variabilidad en la explotación y procesamiento de ungulados en el sector centro-oriental de la Región pampeana","resumen":"Se analiza la explotación de ungulados por parte de los grupos cazadores-recolectores que ocuparon  el sector centro-oriental de la región Pampeana durante la fase final del Holoceno tardío (<2000 años  AP). Para ello, consideramos las características eto-ecológicas de los principales taxa explotados  (Lama guanicoe, Blastocerus dichotomus y Ozotoceros bezoarticus) y comparamos la información  arqueofaunística procedente de dos sitios arqueológicos situados en dos de las unidades del paisaje  que integran la región bajo estudio. A partir de los resultados obtenidos, mediante la aplicación de  diferentes índices, se postulan distintas hipótesis con el fin de establecer y discutir similitudes y  diferencias relacionadas con la importancia económica que adquirieron dichas presas y las modalidades  utilizadas para su procesamiento y consumo.","palabras_clave":"Arqueología|cazadores-recolectores|Holoceno|Región Pampeana"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1211,"idioma_id":4,"titulo":"A Branch-and-Cut Algorithm for the Latent Class Logit  Assortment  Problem.","resumen":"                          We study the product assortment problem of a retail operation that faces a stream of customers who are heterogeneous with respect to preferences. Each customer belongs to a market segment characterized by a consideration set that includes the alternatives viewed as options, and by the preference weights that the segment assigns to each of those alternatives. Upon arrival, he checks the offer set displayed by the firm, and either chooses one of those products or quits without purchasing according to a multinomial logit (MNL) criterion. The firm´s goal is to maximize the expected revenue extracted during a fixed time horizon. This problem also arises in the growing area of choicebased, network revenue management, where computational speed is a critical factor for the practical viability of a solution approach.                          This so-called latent-class, logit assortment problem is known to be NP-Hard. In this paper, we analyze unconstrained and constrained (i.e., with a limited number of products to display) versions of it, and propose a branch-and-cut algorithm that is computationally fast and leads to (nearly) optimal solutions.","palabras_clave":"RETAIL OPERATIONS|REVENUE MANAGEMENT|CHOICE BEHAVIOR|MULTINOMIAL LOGIT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1241,"idioma_id":5,"titulo":"Tecnología lítica en las sierras de El Alto-Ancasti, Catamarca","resumen":"Las sierras de El Alto-Ancasti (Departamento Ancasti, provincia de Catamarca) han sido históricamente construidas como áreas de transición cultural entre la región andina hacia el oeste y la región chaco-santiagueña hacia el este, constituyéndose como un sector poco poblado, donde se habrían desarrollado dos prácticas principales: el pastoreo de camélidos y la realización de rituales basados en el consumo del cebil y la representación de escenas a través del arte rupestre en cuevas y aleros. Sin embargo, trabajos recientes han comenzado a evidenciar otra forma de ocupación del espacio, relacionada con prácticas agrícolas y unidades habitacionales. Estas evidencias estarían vinculadas a ocupaciones humanas permanentes con una inversión de trabajo a largo plazo.  El objetivo específico de este trabajo es profundizar la escala doméstica en esta área, específicamente  en lo que se refiere a prácticas desarrolladas allí e interpretadas a través del estudio de los materiales líticos tallados recuperados de la excavación de dos recintos del sitio El Taco 19 (ET19). Estos materiales permitirán un acercamiento a la selección de materias primas para la manufactura de instrumentos, así como también a las características tecnológicas de estos conjuntos y a las posibles prácticas en las que habrían participado.","palabras_clave":"ANCASTI|PRÁCTICAS SOCIALES|TECNOLOGÍA|LÍTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1253,"idioma_id":5,"titulo":"Microrrestos vegetales en campos de cultivo del primer milenio de la era en el valle de Tafí (Prov. de Tucumán, República Argentina)","resumen":"El presente articulo tiene como objetivo principal contribuir a la discusión acerca de la producción de alimentos durante el primer milenio de la Era en el Valle de Tafí a través de la identificación de microrrestos presentes en sedimentos asociados a campos de cultivo. Los resultados obtenidos se integran con las características arquitectónicas y de emplazamiento de las estructuras agrícolas. La combinación de múltiples lineas de evidencia permitió reconocer la funcionalidad de las instalaciones y los recursos vegetales cultivados","palabras_clave":"CAMPO DE CULTIVO|MICRORRESTOS|PRIMER MILENIO DE LA ERA|VALLE DE TAFI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1257,"idioma_id":5,"titulo":"Esbozo fonológico del chorote (mataguayo)","resumen":"Este artículo describe lo esencial de la fonología de la lengua chorote (familia mataguaya), hablada en el oeste del Chaco argentino y paraguayo y en torno a la ciudad de Tartagal (Salta, Argentina), más concretamente de la variedad ?ribereña? o iyojwa?(a)ja?, hablada sólo en la Argentina. La fonología de esta lengua, y muy especialmente de la variedad estudiada, presenta una complejidad importante. De acuerdo con el análisis propuesto aquí, existen al menos 36 fonemas consonánticos, de los cuales 25 son consonantes complejas (principalmente glotalizadas, ?aspiradas? y\/o palatalizadas); esto permite postular una estructura silábica CV(C). En cuanto a las vocales, se proponen seis fonemas subyacentes \/a &#945; e i o u\/, aunque en realidad no ocurre una oposición superficial [a ~ &#945;] y sí, en cambio, oposiciones [i ~&#61513;], [u ~ &#650;] que aquí se consideran derivadas. Se documenta asimismo un proceso ?con paralelos en otras lenguas de la familia? por el cual se glotaliza una sonante ante pausa; las excepciones se atribuyen a \/h\/ subyacente que forma parte de la entrada léxica y bloquea el proceso.iyojwa?(a)ja?, hablada sólo en la Argentina. La fonología de esta lengua, y muy especialmente de la variedad estudiada, presenta una complejidad importante. De acuerdo con el análisis propuesto aquí, existen al menos 36 fonemas consonánticos, de los cuales 25 son consonantes complejas (principalmente glotalizadas, ?aspiradas? y\/o palatalizadas); esto permite postular una estructura silábica CV(C). En cuanto a las vocales, se proponen seis fonemas subyacentes \/a &#945; e i o u\/, aunque en realidad no ocurre una oposición superficial [a ~ &#945;] y sí, en cambio, oposiciones [i ~&#61513;], [u ~ &#650;] que aquí se consideran derivadas. Se documenta asimismo un proceso ?con paralelos en otras lenguas de la familia? por el cual se glotaliza una sonante ante pausa; las excepciones se atribuyen a \/h\/ subyacente que forma parte de la entrada léxica y bloquea el proceso.","palabras_clave":"CHOROTE|MATAGUAYO|FONOLOGÍA|CONSONANTES COMPLEJAS|PALATALIZACIÓN|LARÍNGEAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1271,"idioma_id":5,"titulo":"La recepción del pensamiento de Juan Escoto Eriúgena en las historias de la filosofía alemanas de los siglos XVIII y XIX","resumen":"Este artículo es un resumen de la tesis doctoral 'La recepción del pensamiento de Juan Escoto Eriúgena en las historias de la filosofía alemanas de los siglos XVIII y XIX' defendida el 18 de junio de 2012 en la Facultad de Filosofía y Letras de la UBA, que obtuvo la máxima calificación. LA tesis fue dirigida por la Dra. Claudia D´Amico y la Dra. Silvia Manzo.","palabras_clave":"ERIÜGENA|HISTORIOGRAFÏA FILOSÖFICA|NEOPLATONISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1275,"idioma_id":5,"titulo":"Entre el aislamiento y la interacción: la circulación de información en el trabajo en el servicio doméstico.","resumen":"Esta revista está indexada en Latindex Catálogo.Los autores aparecen en la publicación según el orden alfabético de sus apellidos.Una de las características del trabajo doméstico remunerado es su desarrollo en el domicilio privado del empledor. Esta característica implica el aislamiento de las trabajadoras durante la mayor parte de su jornada de trabajo, lo que impone grandes obstáculos al desarrollo de instancias de acción colectiva. Sin embargo, el trabajo en el servicio doméstico también transcurre en  espacios que trascienden los límites de los domicilios particulares.  Si bien a veces se trata de lugares en los que se permanece por poco  tiempo (plazas, comercios, espacios comunes de edificios, etc.), constituyen puntos de encuentro con otras trabajadoras que  posibilitan el intercambio de experiencias de trabajo, intercambios  en los que circula información sobre la actividad que resulta de un  valor central para las mujeres que se desempeñan en este sector. Así, la circulación de información se insinúa como un  componente de importancia tanto en la configuración de las  relaciones de trabajo en las que se insertan las mujeres empleadas en  el servicio doméstico, como en las posibilidades de organización  colectiva. Sobre la base de un estudio cualitativo, el objetivo de este artículo  es indagar en torno de la manera en que esta información afecta la  configuración de la relación laboral entre trabajadoras y  empleadores\/as y en las condiciones de trabajo de las primeras. Para ello, luego de una breve caracterización de este sector de  actividad en la Argentina, nos centraremos en el análisis de los  espacios que habilitan estos intercambios, el tipo de información  que allí circula y la especificidad del rol que cumplen las  organizaciones colectivas de trabajadoras domésticas. En un segundo  momento, abordaremos la manera en que esa información es movilizada  por las empleadas en sus experiencias cotidianas de trabajo.","palabras_clave":"Servicio doméstico|Trabajadoras domésticas|Información|Sindicatos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1285,"idioma_id":5,"titulo":"Hallazgo de sepiolita en serpentinitas, Mina Arbol Seco, Provincia de Córdoba.","resumen":"El área mineralizada Blancón está ubicada a unos 9 km de la localidad de Los Menucos, provincia de Río Negro. El yacimiento de caolín está emplazado en una toba riolítica de la Formación Sierra Colorada de edad triásica media - jurásica media. Se realizaron estudios petrográficos sobre secciones delgadas y análisis químicos de elementos mayoritarios, minoritarios y traza sobre roca total. Además se analizaron las venillas de caolín utilizando SEM, DRX, DTA-TG, IR y análisis isotópicos &#948;18O y&#948;D. La presencia de pirofilita y alunita, el elevado contenido de Ba y Sr, la distribución de los elementos de las tierras raras y los valores &#948;18O y &#948;D, permiten concluir que el caolín se formó por alteración hidrotermal de las tobas riolíticas.","palabras_clave":"ALTERACION HIDROTERMAL|MINERALES ARCILLOSOS|PIROFILITA|ALUNITA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1288,"idioma_id":4,"titulo":"As bioaccumulation in Argentinean toad (Rhinella arenarum) larvae by SR-TXRF","resumen":"El arsénico (As) es un contaminante ampliamente distribuido en la naturaleza, es movilizado por agua y puede bioacumularse en especies expuestas. Este elemento resulta altamente tóxico para los procesos biológicos ya que produce estrés oxidativo y lleva a muerte o transformación celular. Debido a que el desarrollo embrionario y larval de los anfibios como el sapo, ocurre en medio acuoso, estos organismos resultan muy apropiados para realizar estudios ecotoxicológicos del As. Además son una pieza clave en la cadena alimenticia en ambientes acuáticos. Recientemente se comenzaron estos estudios en la especie autóctona Rhinella arenarum (sapo común argentino). La técnica SR-TXRF permitió observar que la concentración de As comienza a aumentar a los 8 d¶³as de exposición después de la fertilización de los ovocitos. Esta técnica ha sido empleada para determinar la bioacumulación de As durante el estadio larval, después de los 8 días de incubación y el efecto sobre la concentración de otros elementos. Los resultados se suman al análisis de otros biomarcadores como expresión de quinasas relacionadas a estrés oxidativo. Estos estudios permitirán determina","palabras_clave":"ARSÉNICO|RHINELLA ARENARUM|SR-XRF"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1295,"idioma_id":4,"titulo":"Non-empty core-type solutions over balanced coalitions in TU-games","resumen":"In this paper we introduce two related core-type solutions for games with transferable utility (TU-games) the B-core and the M-core. The elements of the solutions are pairs (x,B), where x, as usual, is a vector representing a distribution of utility and B is a balanced family of coalitions, in the case of the B-core, and a minimal balanced one, in the case of the M-core, describing a plausible organization of the players to achieve the vector x. Both solutions extend the notion of classical core but, unlike it, they are always non-empty for any TU-game. For the M-core, which also exhibits a certain kind of 'minimality' property, we provide a nice axiomatic characterization in terms of the four axioms non-emptiness, individual rationality, superadditivity and a weak reduced game property (with appropriate modifications to adapt them to the new framework) used to characterize the classical core. However, an additional axiom, the axiom of equal opportunity is required. It roughly states that if (x,B) belongs to the M-core then, any other admissible element of the form (x,B&#8242;) should belong to the solution too.","palabras_clave":"COOPERATIVE GAMES|CORE|BALANCED FAMILIES OF COALITIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1302,"idioma_id":5,"titulo":"DETERMINACIÓN DE LA TEMPORALIDAD INTERNA DE LOS ESTADOS RESULTATIVOS A PARTIR DEL FACTOR CAUSA. EXPRESIONES DE ESTADO Y RELACIONES PREDICATIVAS ESPACIALES","resumen":"Que las construcciones copulares españolas presentan propiedades aspectualmente diferentes no es una premisa nueva. En particular, el presente trabajo apela a las nociones de [TERMINUS] y [MEASURE] (Tenny 1994) como alternativa para abordar las propiedades aspectuales que diferencian a parecer y estar (tanto entre ellos como con respecto a ser). En un caso, se sugiere que la causa\/iniciador del cambio de estado (hay un C tal que X llega al estado E) asociado a la predicación resultativa involucra un [TERMINUS], y que esta proyección corresponde al estado (resultante) articulado mediante estar (Causa&#8594; X pasa de estado Z a estado E&#8594; TERMINUS=X\/E es verdadero). En el segundo caso, proponemos que lo que se encuentra implícito en la semántica de permanecer es un fin que ha sido demorado (si algo permanece en estado E es porque se esperaba que ese estado llegara a fin y esto no sucede), determinando un período temporal durante el cual la relación entre el atributo y el sujeto se prolonga. De explicitarse un causante\/fuente (hay un C tal que X permanece en estado E), se podría decir que su incidencia mide la duración del estado denotado mediante permanecer, proporcionando el parámetro temporal de vigencia del estado predicado [MEASURE] (Causa&#8594; X permanece en estado E (no pasa a estado Z)&#8594; MEASURE=X\/E es verdadero).","palabras_clave":"CAUSA |MEASURE |TERMINUS |TEMPORALIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1316,"idioma_id":4,"titulo":"Local influence for functional comparative calibration models with replicated data","resumen":"We investigate local influence analysis in functional comparative calibration models with replicated data. A method for selecting appropriate perturbation schemes based on the expected Fisher information matrix with respect to the perturbation vector is proposed. It is shown that arbitrarily perturbing these models may result in misleading inference about the influential subjects. First-order influence measures for identifying the correct influential subjects and replicates on corrected score estimators are defined. We introduce different perturbation schemes including perturbation of subjects and replicates on the corrected likelihood function and obtain the density of the perturbed model from which the methodology is based. Particularly, three perturbation of variances schemes could be a better way to handle badly modeled subjects or replicates. Two real data sets are analyzed to illustrate the use of our local influence measures.","palabras_clave":"LOCAL INFLUENCE|COMPARATIVE CALIBRATION|REPLICATE MEASUREMENT|CORRECTED SCORE|APPROPRIATE PERTURBATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1353,"idioma_id":4,"titulo":"Recent Publications in Sociology - Argentina and Uruguay","resumen":"El artículo sistematiza y anota las publicaciones recientes en sociología política del Cono Sur.","palabras_clave":"Sociologia|Argentina|Chile|Uruguay"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1374,"idioma_id":5,"titulo":"Editorial de la Revista CREAR en salud","resumen":"Uno de los retos actuales de nuestra disciplina en el campo de la salud, es  el de conocer y debatir los modelos hegemónicos de la modernidad. Estos,  inscriptos en la cultura occidental son considerados como de validez universal,  por lo que generalmente el colectivo adhiere sin demasiados interrogantes y  escasa reflexión.  Interpretar en esta etapa del capitalismo, el cambio en las relaciones de producción,  la idea de Estado nación y las nuevas tecnologías, se convierte en un  imperativo para lograr comprender el lugar social que ocupan las profesiones  y la nuestra en particular.  Las agudas transformaciones económicas y sociales han puesto en cuestión  las instituciones del Estado. Conjuntamente las ideas fuerzas de patrimonio  nacional, derechos de los trabajadores, empleo pleno, educación igualitaria, soportan  una activa devaluación material y simbólica.  El orden capitalista actual, experimenta una modalidad estatal de acuerdo a  éstas transformaciones, subordinado a la mundialización.  Las fuerzas de trabajo fueron tomadas de sorpresa por éstos hechos, y ante  el estallido de su crisis se volvieron sobre sí mismas buscando autopreservarse,  a la espera de mejores épocas, sin preocuparse demasiado por entender las  transformaciones que se operaban y se operan; para apresurarse a organizarse  y resistir esta nueva modernización del capital, depredadora del medio ambiente,  de la vida y del trabajo.  La necesidad del modo de producción capitalista de ampliar constantemente  la inclusión y subsunción de nuevas áreas, al capital, supone un decidido  avance de sus fronteras y de la mercantilización de la vida en su conjunto. Así,  la salud y la educación adquieren en este momento un altísimo valor de mercado,  que nuestra disciplina tendría que poner a la discusión para poder tomar  decisiones que marquen las diferencias y nos orienten de manera autónoma a  lograr avances profesionales.  La cultura postmoderna pregona la diversidad, la especificidad, la contingencia,  la lucha contra las totalizaciones desde una nueva cartografía del espacio  social y de nuevas tecnologías, a la vez que genera formas y relaciones sociales  con nuevas fragmentaciones dentro de la sociedad.El resultado se expresa en un descentramiento del sujeto y una problematización  de la representación política, académica, científica como creadora de  realidad.  Es una constante en esta heterogénea realidad, que muchos pensadores  describen como la sociedad del conocimiento, que se instaló exigiendo cada vez  más capacidades y saberes para poder desempeñarse en ella; convirtiéndolo en  un elemento esencial para el capital. De esta manera se orientan los procesos  de producción y reproducción del conocimiento buscando concordar con las  mismas lógicas de producción y reproducción del capital, llevando en la práctica  a sostener la creciente desigualdad.  Desde la influencia pedagógica se construye una realidad que tiende a sostener  las relaciones de dominación, excluyendo voces y experiencias de los  grupos subordinados por medio de procedimientos normalizados, prácticas  normativas, y jerarquías simbólicas hegemónicas. El aprendizaje se construye  así como mera trasmisión de contenidos y destrezas que deben ser perfeccionadas,  reproduciendo el pragmatismo que permea la cultura occidental.  Pensar estos problemas, en torno a cuestiones como las transformaciones  sociales y las formas de las políticas educativas frente a las crisis de los viejos  métodos de organización, y los desafíos planteados por los sujetos de la educación  emergentes de nuevas formas de organización es una tarea postergada,  y hoy, inaplazable.  La situación actual en nuestro espacio laboral, demanda una educación más  crítica, que busque develar las prácticas institucionales de dominación, instituidas,  que pujan por expresarse a través de relaciones laborales con altos  contenidos de violencia simbólica.  Se trata de replantear nuestras propias prácticas educativas y de organizar  nuevas, capaces de confrontar los estudiantes con sus propias experiencias de  clase, de género y con lo que podría ser una sociedad justa.  La idea de una democracia radical constituye una necesidad para la formación  de ciudadanos críticos. A la vista de los resultados, hoy cabría confrontar  nuestro quehacer y hasta poner en discusión nuestros propios referentes teóricos.  Cuando los profesionales no permanecen fieles a su vocación, no se acogen  a su tarea, cuando solo buscan hacerse visibles individualmente porque olvidan que lo propio del hombre es ser y no parecer, en tales momentos de declive, queda todavía una última solución, debatir sobre el tema del papel del profesional,del docente en la sociedad, de plantear lo que piensan de ellos mismos y de librar sus opiniones sobre la manera en que recapacitan y valoran su papel  social.","palabras_clave":"Investigación|Salud|Enfermería"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1376,"idioma_id":4,"titulo":"Executive function task predictions of academic and social school performance","resumen":"Executive functions (EFs) were examined in primary and secondary school students between 8 and13 years of age with two classical tasks, Verbal Fluency (VF) and Trail Making Test (TMT), to assess their predictive power on academic achievement and social behavior. Results confirm  the development of EFs in these ages and the high predictive power of this &#8215;low-cost? EF battery.  Performance in VF-Verbs and TMT-B predicts around 50% of the variance in measures of academic achievement. TMT-B also predicts approximately 40% of the variance related to prosocial behavior and sociometric status, especially in childhood. Our results suggest that &#8215;lowcost? EF battery has reduced time costs and allow the detection of students that require additional academic support to improve their performance.","palabras_clave":"Executive functions|Academic performance|Prosocial behavior|Sociometric studies"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1397,"idioma_id":4,"titulo":"Na2SO4 and NaCl determine different growth responses and ion accumulation in the halophytic legume Prosopis strombulifera","resumen":"Halophytes are potential gene donors for genetic manipulation of economically important crop species. This study addresses the physiological responses of a widespread halophyte species, Prosopis strombulifera (Lam.) Benth. to salinity. We hypothesized that increasing concentrations of the two major salts present in soils of central Argentina (Na2SO4, NaCl, or their iso-osmotic mixture) would produce distinct physiological responses. We used hydroponically grown P. strombulifera plants to test this hypothesis, analyzing growth parameters, water relations, photosynthetic pigments, cations, and anions. These plants showed a halophytic response to NaCl, but strong general inhibition of growth in response to iso-osmotic solutions of Na2SO4. The explanation for the adaptive success of P. strombulifera growing under high-NaCl conditions seems to be related to a delicate balance among Na+ accumulation (and its use for osmotic adjustment) and efficient compartmentation in vacuoles, the aptitude of the whole plant to ensure a sufficient K+ supply by maintaining a high degree of K+\/Na+ discrimination, and maintenance of normal Ca2+ levels in leaves. The three salt treatments had differential effects on accumulation of ions. Findings in bi-saline-treated plants were of particular interest, where most of the physiological parameters studied in these plants showed a partial alleviation of SO42--induced toxicity by Cl-. Thus, discussion on physiological responses to salinity could be further expanded in a way that more closely mimics natural salt environments.","palabras_clave":"HALOPHYTES|SULFATE|CHLORIDE|TOXICITY ALLEVIATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1399,"idioma_id":5,"titulo":"PERO SI SON MÁQUINAS, NO MÚSICOS. El estudio histórico de la música electroacústica a partir de las relaciones sociales","resumen":"La práctica musical compositiva que utiliza medios electrónicos en el campo de la música académica centroeuropea se ha presentado históricamente determinada por los medios de producción y la presencia de compositores destacados. Sin embargo, la existencia de instrumentos electrónicos y eléctricos data de mediados de siglo XVIII en la propia Europa central. También es anterior, y en cantidades no menos significativas, la existencia de músicos interesados en el desarrollo de músicas mediadas por tecnologías electrónicas o eléctrica. No obstante, la composición musical que prescindió del intérprete, que se modificó en las formas de circulación, que incluyó otras fuentes sonoras no fue posible de practicarse en forma sistemática y mayoritariamente estandarizada ni en el siglo XVIII, y tampoco durante el siglo XIX. Sólo será posible en la medida en la que una confluencia de situaciones, relativas a las condiciones de producción y de difusión musicales, se desarrollen en estricta vinculación con el inicio de la Guerra Fría, la promoción cultural del mundo capitalista occidental y el impacto de la existencia de la grabación aplicada a la realización musical. El presente trabajo pretende indagar en los aportes que al estudio de la música electrónica puede realizar la inclusión de perspectivas teóricas de la nueva historiografía musical. De esta manera, repensar las correspondencias entre la promoción cultural llevadas a cabo por el Estado de Bienestar a mediados de siglo XX en Europa central, las relaciones entre los laboratorios de música electroacústica y las radios estatales, los festivales de música contemporánea y los conflictos entre intérpretes y compositores, las relaciones sociales entre músicos, técnicos e ingenieros de sonido, así como el impacto de tales obras en el público. La presentación de la relación entre producción musical y tecnología como unidireccional conlleva el presupuesto de que la existencia de un dispositivo es el motor de cambio de las necesidades estéticas de una determinada sociedad en un determinado momento histórico. El reconocimiento de que lo tecnológico está socialmente construido colabora con la comprensión de los alcances que puede tener una sociedad configurada tecnológicamente.","palabras_clave":"Musica electroacustica|Musica Contemporanea|historia de la musica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1407,"idioma_id":5,"titulo":"Tus amigos son mis amigos: agentes y estado en un paso argentino de frontera","resumen":"Los pasos de frontera con Paraguay que caracterizan a la provincia de Misiones, Argentina, se han constituido como lugares privilegiados para la circulación de personas y mercancías en formas no siempre legales. En este artículo abordaré algunas dinámicas fronterizas que se configuran como prácticas comunes, a pesar de ser muchas de ellas ilegales. La distinción entre lo legal y lo ilegal resulta de una clasificación que presupone adhesión al concepto de Estado como mejor forma de administración; pero también al de Nación, como expositor de un sentido de comunidad compartido. A partir de episodios, situaciones y eventos que se dieron en diferentes momentos de mi trabajo de campo, analizaré el modo en que prácticas calificadas como ilegales, sean llevadas a cabo por parte de habitantes y comerciantes de las ciudades en frontera, como por agentes de seguridad y de Estado, se inscriben en un universo más amplio de tradiciones políticas y formas de disidencia al interior del territorio argentino, y en referencia al Estado y a la Nación.","palabras_clave":"Frontera|Estado|Contrabando|Ilegalismos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1412,"idioma_id":5,"titulo":"Carandá libertada. La periferia de un pueblo de frontera","resumen":"Durante las últimas décadas del siglo XX la literatura producida y publicada en Argentina se ha presentado como espacio de reflexión  conflictivo entre política e intelectualidad. A partir del retorno a la democracia, los debates intelectuales se intensificaron y comenzó a diversificarse el terreno literario de manera significativa. En este sentido, nos interesa particularmente indagar sobre la cuestión de lo periférico en el discurso literario editado en este período.  El presente trabajo analiza la representación de la periferia a través de la cuestión de los pueblos de frontera en la novela Carandá libertada o Cruzada de salvación de la frontera (1988) del escritor Renato Peralta.","palabras_clave":"FRONTERA|PERIFERIA|NOVELA ARGENTINA|DÉCADA DEL 80|CÓRDOBA|RENATO PERALTA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1427,"idioma_id":5,"titulo":"Los estados de la teoría. Notas sobre la universidad argentina de la posdictadura","resumen":"Este artículo presenta, a modo de notas, un conjunto de problemas que giran en torno a representaciones de la teoría literaria y sus derivas en las prácticas de investigación, enseñanza y extensión. Si bien se centra en el nivel superior universitario y en el corte temporal de la posdictadura argentina (1984-2003), enlaza resultados de investigaciones previas. En primer lugar, sobre el nivel medio: por un lado, recoge análisis de las consecuencias de la reforma educativa de los años noventa sobre la trama completa de la educación pública; por el otro, retoma el diagnóstico sobre los obstáculos ideológicos y epistemológicos que impiden las prácticas de enseñanza. En segundo lugar, considerando el furor con que Argentina ha importado teorías francesas, compara, a partir de algunos textos puntuales, el tipo de problemas existentes en la relación teoría-enseñanza en ambos países, tradicionalmente caricaturizados en los roles más o menos fijos de productor\/receptor de conocimiento. Los problemas que se describen son: 1- la demonización de la teoría y los malentendidos que esto genera; 2- su eclipse tanto bajo las formas del aplicacionismo, del diseccionismo (o deteccionismo) y de la sinécdoque lingüisticista como del uso gratuito, decorativo y esnob; 3- la confusión entre su institucionalización y su escolarización; 4- su reducción a cada de herramientas.","palabras_clave":"TEORÍA LITERARIA|ENSEÑANZA |ARGENTINA|POSDICTADURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1455,"idioma_id":5,"titulo":"EVALUACION DE COMPETENCIAS ORALES COMO INSUMO PARA MEJORAR LA PROPUESTA EDUCATIVA","resumen":"Actualmente siguen empleándose métodos de enseñanza y evaluación de la Matemática que enfatizan el manejo conceptual y procedimental, donde el alumno debe resolver problemas estándar en un determinado tiempo. Esta visión no considera importantes variables que influyen en el proceso educativo, imposibilitando su uso como insumo del mismo. Para modificar esto es preciso presentar la Matemática enmarcada en situaciones reales que alienten al estudiante, desafiando su interés. En la Facultad de Medicina Veterinaria (UNL) un grupo de docentes está trabajando en una propuesta de Aprendizaje Cooperativo, estimulando y evaluando habilidades sociales. En este trabajo se evaluaron habilidades orales en base a reportes de problemas de Medicina Veterinaria que utilizan modelos matemáticos sencillos. Para ello se empleó una grilla, resultando que los alumnos presentan dificultades para expresar verbalmente dichos modelos, manifestando inseguridad. Se intenta ofrecer un espacio donde sea posible corregir competencias comunicativas no asertivas que limitan a los estudiantes.","palabras_clave":"COMPETENCIAS ORALES|APRENDIZAJE |MATEMATICA|EVALUACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1456,"idioma_id":4,"titulo":"Sperm membrane functionality in the dog assessed by flow cytometry","resumen":"The objective assessment of sperm function increases the chances of predicting the fertilizing capacity of a fresh semen sample or diagnosing infertility problems. In this study, the available flow cytometry technique was used to determine the membrane functional capacity of canine spermatozoa. The second fractions of ejaculates from six dogs were pooled, and samples (n = 26) processed to determine the variables: sperm  viability and plasma membrane integrity staining; phosphatidylserine (PS) translocation by Annexin-V-FITC and PI labelling; acrosome membrane integrity by FITC-conjugated Pisum sativum agglutinin &#8260; PI labelling; and  mitochondrial membrane potential (DYm) by staining with. Means for the 26 examined samples indicated that 82.66 ± 2.8% of the viable spermatozoa showed an intact plasma membrane, 8.4 ± 2.6% were moribund, 72.7 ± 16%  had an intact acrosome, 80.9 ± 17% had high DYm and 8.1 ± 11% had PS translocation with a PS translocation index of 2.1 ± 3%. Motility was only correlated with PS translo-cation (R = 0.3901; p = 0.0488), and acrosome membrane integrity was correlated with PS translocation (R = 0.5816;>p = 0.0018). This study provides objective physiological data on the functional capacity of canine spermatozoa.","palabras_clave":"espermatozoides|perro|citometria de flujo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1462,"idioma_id":4,"titulo":"Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide","resumen":"Nucleic Acid Therapeutics is combined to include former title of the journal: Oligonucleotides.                                                            IMT504 is a non-CpG 24-mer oligodeoxynucleotide (ODN) with immunomodulatory as well as tissue repair activity. IMT504 has been previously proven to be effective in animal models of vaccine potency, chronic lymphocytic leukemia, tissue regeneration, and sepsis. Here, we assessed the safety, including pharmacokinetics and toxicity studies in rats and monkeys, of IMT504 in a single- or repeated-dose administration by the subcutaneous (SC) or intravenous (IV) routes. In rats, the maximum tolerated dose was determined to be 50&#8201;mg\/kg when administered SC. Adverse effects at 50&#8201;mg\/kg were mild and reversible liver injury, revealed as lobular inflammation, focal necrosis, and small changes in the transaminase profile. Dose-dependent splenomegaly and lymphoid hyperplasia, most probably associated with immune stimulation, were commonly observed. Rats and monkeys were also IV injected with a single dose of 10 or 3.5&#8201;mg\/kg, and no adverse effects were observed. Rats injected IV with 10&#8201;mg\/kg showed a transient increase in spleen weight, together with a slight increase in the marginal zone of the white pulp and in leukocyte count 2 days post-administration. In monkeys, this dosage caused slight changes in total serum complement and leukocyte count on day 14. No adverse effects were observed at 3.5&#8201;mg\/kg IV in rats or monkeys. Therefore, this dose was defined as the 'no observed adverse effect level' for this route. Furthermore, repeated-dose toxicity studies were performed in these species using 3.5 or 0.35&#8201;mg\/kg\/day IV for 6 weeks. A transient increase in the spleen and liver weight was observed at 3.5&#8201;mg\/kg\/day only in female rats. No changes in clotting time and activation of the alternative complement pathway were observed. The toxicity profile of IMT504 herein reported suggests a dose range in which IMT504 can be used safely in clinical trials.","palabras_clave":"IMT504|non-CpG|Safety|Toxicity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1466,"idioma_id":4,"titulo":"Comparison between isoelectric precipitation and ultrafiltration processes to obtain Amaranth mantegazzianus protein concentrates at pilot plant scale","resumen":"The aim of this study was to compare protein yield, protein concentration and physicochemical characteristics of Amaranth mantegazzianus protein concentrates (APC) obtained at pilot-scale by a conventional process (CP) (alkaline extraction and isoelectric precipitation) and two alternative processes (AP): (1) acid pre-treatment process combined with isoelectric precipitation and (2) acid pre-treatment process combined with ultrafiltration. Although AP resulted in higher protein concentration, protein yield was lower than in CP. SDS?PAGE and size-exclusion chromatography showed high molecular weight fractions only for isoelectric precipitation concentrates (obtained by CP and AP). The amino acids concentration, especially phenylalanine, isoleucine and methionine, increased in all protein concentrates respect to the amaranth flour. Particularly, the product obtained by ultrafiltration was rich in phenylalanine and lysine, and presented no limiting amino acid with respect to the recommendation of the Food and Agriculture Organization of the United Nations (FAO). In conclusion, process (2) improved protein concentration and nutritional quality (balanced amino acid composition) of A. mantegazzianus protein concentrates respect to CP and process (1), suggesting that the ultrafiltration process is a viable alternative to conventional process and a promising method for obtaining protein concentrates.","palabras_clave":"Amaranth| Isoelectric precipitation|Ultrafiltration|protein"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1493,"idioma_id":5,"titulo":"Identificación de los escorpiones de importancia médica en la Argentina","resumen":"Los escorpiones de importancia médica en el  mundo pertenecen mayoritariamente a la familia Buthidae. En Argentina, los  miembros de esta familia no son numerosos, siendo mucho mayor el número de  especies de la familia Bothriuridae, cuyos miembros hasta el momento no  revisten importancia médica. Dentro de los tres géneros de Buthidae que viven  en el país, el género Tityus es el que posee especies cuya picadura e  inoculación de veneno puede provocar accidentes severos. En general, la  diferenciación entre Tityus trivittatus, el escorpión de mayor  importancia médica de Argentina, respecto a otros escorpiones, es fácil en las  provincias de la zona central del país. Sin embargo, las reglas a utilizar para  la diferenciación entre escorpiones de importancia médica de aquellos que no la  tienen, no son similares en todo el país. En esta actualización, se brindan  elementos sencillos y claros para que el personal de salud pueda diferenciar  entre las especies de Tityus de importancia médica de los escorpiones de  la familia Bothriuridae, ampliamente distribuidos en la superficie del país. De  esta forma, se espera que el diag­nóstico acertado sobre la especie de  escorpión pueda mejorar la atención en el caso de la picadura por animales  potencialmente peligrosos. Por otro lado, permitirá diferenciar a los escorpiones  sin importancia médica lo que redundará en la mejor utilización de los recursos  disponibles en los niveles de atención primaria, ante la emergencia que  representa una picadura de alacrán.","palabras_clave":"ESCORPIÓN|TITYUS|IDENTIFICACIÓN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1495,"idioma_id":5,"titulo":"Relevamiento de programas y actividades de atención a la temprana infancia en la ciudad de La Plata","resumen":"En este trabajo presentamos los avances de nuestra investigación, donde buscamos relevar los programas y\/o actividades de Atención Temprana que se desarrollan en instituciones dependientes de salud y educación provinciales y municipales de la ciudad de La Plata. El objetivo se orienta a identificar las instituciones que las llevan a cabo, la población a las que van dirigidas esas actividades, los profesionales que intervienen y las necesidades que identifican esos profesionales, así como la valoración que hacen de su propia formación para intervenir en esos procesos, teniendo en cuenta la importancia otorgada en el mundo a estas acciones preventivas e inclusivas.  Se realiza un diagnóstico de situación con un diseño de tipo descriptivo y flexible, cuya metodología consiste en administrar una entrevista estructurada a informantes clave que se desempeñan en instituciones seleccionadas para el relevamiento.  El análisis de los primeros resultados muestra que en la ciudad de La Plata se desarrollan diversas prácticas de Atención Temprana, dirigidas a niños y niñas con discapacidades, con trastornos generales del desarrollo y en vulnerabilidad psicosocial. Sin embargo, muchas de estas actividades se realizan en escuelas o centros de salud que se encuentran alejados de la población que más puede requerir de esos servicios.","palabras_clave":"ATENCIÓN TEMPRANA |DESARROLLO PSICOLÓGICO|PRIMERA INFANCIA|PREVENCIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1497,"idioma_id":5,"titulo":"caracterizacion de la vasculatura venosa hepatica a traves de la ultrasonografia doppler en caninos sanos de raza beagle.","resumen":"Los autores describieron la técnica para el abordaje de las venas hepáticas, venas portales y de la vena cava caudal. Las características principales de la vasculatura fueron detalladas mediante la técnica ultrasonográ ca bidimensional y Doppler (espectral y color). Los valores de velocidades medias obtenidos en 11 caninos beagle sanos correspondientes a los vasos principales hepáticos fueron analizados según las medidas resumen de la estadística descriptiva. Los valores medios registrados expresados en cm\/seg, fueron: VP (Vena Porta) 20,26±2,84; VPI (Vena Porta Izquierda) 21,46±6,20; VPLI (Vena Porta Lateral Izquierda) 15,81±3,33; VPMI (Vena Porta Medial Izquierda) 17,18±5,46; VPQ (Vena Porta Lóbulo Cuadrado) 13,30±4,19; VPD (Vena Porta Derecha) 18,67±4,77; VPMD (Vena Porta Medial Derecha) 20,03±4,3; VPLD (Vena Porta Lateral Derecha) 15,23±4,72; VPC (Vena Porta Caudado) 17,08 (valor único); VHI (Vena Hepática Izquierda) 27,67±7,31; VHLI (Vena Hepática Lateral Izquierda) 24,92±2,83; VHMI (Vena Hepática Medial Izquierda) 23,74±4,72; VHQ (Vena Hepática Cuadrado) 16,73±5,20; VHMD (Vena Hepática Medial Derecha) 20,89±5,11; VHLD (Vena Hepática Lateral Derecha) 15,91±6,0; VHC (Vena Hepática Caudado) 20,33±3,63; VCCpos (Vena Cava pos renal) 26,64±5,62; VCCren (Vena Cava renal) 39,95±10,6; VCCpre (Vena Cava pre renal) 52,83±13,36.","palabras_clave":"Doppler vascular|caninos beagle|vasculatura venosa hepática|anatomía hepática"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1506,"idioma_id":5,"titulo":"ESTUDIO DE LA ADHESIÓN DE CERÁMICOS A RESINAS POLIMÉRICAS USADAS EN ODONTOLOGÍA","resumen":"Objetivos: evaluar la adhesión cerámico-polímero en materiales usados en restauraciones odontológicas de alta resistencia (alúmina, zirconia) luego del tratamiento de la superficie cerámica. Materiales y métodos: se confeccionaron probetas con un cerámico a base de alúmina y sus superficies fueron modificadas a partir de vidriados y de la posterior formación de microencastres, mediante la sinterización de microesferas o de ataques químicos sobre una capa vítrea previamente sinterizada sobre ellas. Dos de las probetas fueron unidas mediante un adhesivo polimérico, a fin de determinar, bajo tensiones de corte, la resistencia y la tenacidad al despegue y el módulo de corte, en todos los casos, en megapascales y en un mínimo de 15 ensayos por condición experimental. Resultados: se obtuvieron valores medios de resistencia al despegue de entre 7 y 13 MPa; de tenacidad al despegue de entre 3 y 10 MPa, y de módulo de corte entre 5 y 13 MPa. Conclusión: la valoración del desempeño mecánico demuestra que las modificaciones superficiales de los cerámicos generan un comportamiento adhesivo mejorado respecto de lo que ocurre con cerámicos sin modificaciones","palabras_clave":"Ceramicos|Resinas|Odontologia|Adhesion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1516,"idioma_id":5,"titulo":"Notas sobre la voluntad de cambio en el espacio público: la importancia de la intervención en comunicación","resumen":"En este artículo, presentamos el avance sobre una primera  etapa, analítico conceptual de la investigación 'Representaciones  temporales y prácticas sociales: el cambio social a partir de la intervención  en el espacio público', cuyo objetivo consiste en indagar las relaciones  que se establecen entre las intervenciones en el espacio público de la ciudad de La  Plata, realizadas intencionalmente por grupos locales, y el cambio social (como  modos de vincular las concepciones temporales del futuro con las instancias de  socialidad). Si bien entendemos que las categorías analíticas se irán  (re)construyendo en relación con los observables durante una etapa posterior  del proyecto, presentamos un recorrido por las nociones centrales abordadas en  una primera etapa: representaciones, representaciones temporales, cambio  social, intervención y espacio público.","palabras_clave":"Espacio público|Cambio social|Representaciones sociales|Intervención"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1521,"idioma_id":4,"titulo":"Therapeutic potential of the thymic peptide thymulin","resumen":"xxxAbstract: Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus. After its discovery and initial characterization  in the ?70s, it was demonstrated that the production and secretion of thymulin are strongly influenced by the neuro-endocrine  system. Conversely, a growing body of evidence, to be reviewed here, suggests that thymulin is a hypophysiotropic peptide. Additionally,  a substantial body of information pointing to thymulin and a synthetic analog as anti-inflammatory and analgesic peptides in the central  nervous system brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence encoding a biologically active  analog of thymulin, metFTS, was constructed and cloned in a number of adenovectors. These include bidirectional regulatable Tet-Off  vector systems that simultaneously express metFTS and green fluorescent protein and that can be down-regulated reversibly by the addition  of the antibiotic doxycycline. A number of recent studies indicate that gene therapy for thymulin may be an effective therapeutic  strategy to prevent some of the hormonal and reproductive abnormalities that typically appear in congenitally athymic (nude) mice, used  as a suitable model of neuroendocrine and reproductive aging. Summing up, this article briefly reviews the publications on the physiology  of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analog. The availability of novel  biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential  of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.","palabras_clave":"thymulin|gene therapy|therapeutic potential"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1523,"idioma_id":4,"titulo":"Growth hormone STAT5-mediated signaling and its modulation in mice liver during the growth period","resumen":"Postnatal growth exhibits two instances of rapid growth in mice: the first is perinatal and independent of growth hormone (GH), the second is peripuberal and GH-dependent. Signal transducer and activator of transcription 5b (STAT5b) is the main GH-signaling mediator and it is related to IGF1 synthesis and somatic growth. The aim of this work was to assess differential STAT5 sensitivity to GH during the growth period in mouse liver of both sexes. Three representative ages were selected: 1-week-old animals, in the GH-independent phase of growth; 2.5-week-old mice, at the onset of the GH-dependent phase of growth; and 9-week-old young adults. GH-signaling mediators were assessed by immunoblotting, quantitative RT-PCR and immunohistochemistry. GH-induced STAT5 phosphorylation is low at one-week and maximal at 2.5-weeks of age when compared to young adults, accompanied by higher protein content at the onset of growth. Suppressor CIS and phosphatase PTP1B exhibit high levels in one-week animals, which gradually decline, while SOCS2 and SOCS3 display higher levels at adulthood. Nuclear phosphorylated STAT5 is low in one-week animals while in 2.5-week animals it is similar to 9-week control; expression of SOCS3, an early response GH-target gene, mimics this pattern. STAT5 coactivators glucocorticoid receptor (GR) and hepatic nuclear factor 1 (HNF1) abundance is higher in adulthood. Therefore, GH-induced STAT5 signaling presents age-dependent activity in liver, with its maximum coinciding with the onset of GH-dependent phase of growth, accompanied by an age-dependent variation of modulating factors. This work contributes to elucidate the molecular mechanisms implicated in GH responsiveness during growth.","palabras_clave":"hormona de crecimiento|periodo de crecimiento|señalización|via JAK2\/STAT5"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1524,"idioma_id":4,"titulo":"Ultra-High Energy Neutrinos at the Pierre Auger Observatory","resumen":"The observation of ultrahigh energy neutrinos (UHEnus) has become a priority in experimental astroparticle physics. UHEnus can be detected with a variety of techniques. In particular, neutrinos can interact in the atmosphere (downward-going nu) or in the Earth crust (Earth-skimming nu), producing air showers that can be observed with arrays of detectors at the ground. With the surface detector array of the Pierre Auger Observatory we can detect these types of cascades. The distinguishing signature for neutrino events is the presence of very inclined showers produced close to the ground (i.e., after having traversed a large amount of atmosphere). In this work we review the procedure and criteria established to search for UHEnus in the data collected with the ground array of the Pierre Auger Observatory. This includes Earth-skimming as well as downward-going neutrinos. No neutrino candidates have been found, which allows us to place competitive limits to the diffuse flux of UHEnus in the EeV range and above.","palabras_clave":"ULTRA HIGH ENERGY NEUTRINOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1525,"idioma_id":4,"titulo":"Changes in secondary structure of gluten proteins due to emulsifiers","resumen":"Changes in the secondary structure of gluten proteins due to emulsifiers were analyzed by Raman Spectroscopy. The protein folding induced by 0.25% SSL (Sodium Stearoyl Lactylate) (GS0.25, Gluten + 0.25% SSL) included an increase in alpha-helix conformation and a decrease in beta-sheet, turns and random coil. The same behavior, although in a less degree, was observed for 0.5% gluten-DATEM (Diacetyl Tartaric Acid Esters of Monoglycerides) system. The low burial of tryptophan residues to a more hydrophobic environment and the low percentage area of the C-H stretching band for GS0.25 (Gluten + 0.25% SSL), could be related to the increased in alpha-helix conformation. This behavior was also confirmed by changes in stretching vibrational modes of disulfide bridges (S-S) and the low exposure of tyrosine residues. High levels of SSL (0.5% and 1.0%) and DATEM (1.0%) led to more disordered protein structures, with different gluten networks. SSL (1.0%) formed a more disordered and opened gluten matrix than DATEM, the last one being laminar and homogeneous.","palabras_clave":"FT-Raman|emulsifier-gluten proteins systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1526,"idioma_id":5,"titulo":"El lago Nahuel Huapi: un registro de erupciones, deslizamientos y tsunamis","resumen":"Desde hace algunos años, investigadoresdel Instituto de Investigaciones en Biodiversidad y Medioambiente (CONICET-Universidad Nacional del Comahue) ydel Instituto Argentino de Oceanografía(CONICET-Universidad Nacional del Sur) estudian los sedimentos y la topografía del lecho del lago Nahuel Huapi. Uno de sus objetivos es analizar los movimientos en masa de sedimentos del fondo lacustre, posibles desencadenantes de tsunamis en estos cuerpos de agua. Se trata de investigaciones novedosas en el país que están abriendo inéditas perspectivas sobre el comportamiento de los lagos andinos de Patagonia Norte frente a la ocurrencia de terremotos de magnitud en la región. Durante la erupción del Cordón Caulle 2011\/12, se estudiaron los deslizamientos subacuáticos y la dinámica de sedimentación de los materiales piroclásticos provenientes de la erupción en los deltas de los arroyos Totoral, Pireco, Bonito,Ñireco y Ñirihuau. Se analizó la evolución de los deltas por acumulación del material piroclástico movilizado por los ríos utilizando fotografías aéreas tomadas en marzo de 2008 y marzo de 2012, es decir, antes y después de la erupción volcánica en Chile. En ellas se advierte un notable crecimiento de la superficie expuesta de los deltas, sobre todo los de los arroyos Totoral y Pireco (unos 30.000m2), los más cercanos al volcán. Esta información concuerda con cálculos preliminares de las tasas de sedimentación en los deltas para los meses iniciales de 2012, cuyos valores crecieron significativamente con relación a los anteriores a la erupción obtenidos en varios lagos de la región. En los frentes de delta se hallaron indicios de dos tipos de fenómenos de remoción en masa: deslizamientos y flujos de detritos. En todos los frentes se advierten evidencias de que esos fenómenos son recurrentes y alternan con superficies no afectadas por movimientos en masa.Se considera que los sectores libres de movilizaciones en masa son especialmente propensos a sufrir una desestabilización. A partir de estos análisis sedimentológicos y de los estudios de la topografía del lecho, los autores esperan poder reconocer los elementos que favorecen la ocurrencia de deslizamientos subacuáticos en el lago Nahuel Huapi, e identificar y caracterizar áreas potencialmente inestables de los deltas estudiados.","palabras_clave":"LAGO NAHUEL HUAPI|TSUNAMIS|VULCANISMO|SISMICIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1527,"idioma_id":4,"titulo":"Analysis of the pX region of bovine leukemia virus in different  clinical stages of Enzootic Bovine Leukemia in Argentine Holstein cattle","resumen":"Bovine leukemia virus (BLV) infection in cattle causes Enzootic Bovine Leukemia (EBL). About 30% of infected cattle develop persistent lymphocytosis (PL), a 0.1?5% develops tumors, and a 70% remains asymptomatic in an aleukemic stage (AL). Regulatory genes of BLV (Tax, Rex, R3 and G4) are located in a region known as pXBLV. The variability of those genes had been postulated with the progression of the disease. The aim ofthis work was to compare the wild-type proviral pXBLV region at different stages of BLV natural infected cattle from Argentine Holstein. Pairs of primers were designed to amplify the proviral pX region of 12 cattle by PCR, and products were then sequenced, aligned and compared both with each other and with the reference sequence. Results show a divergence percentage from 0 to 6.1 for the Taxgene, from 0 to 9.4% for the Rex gene, from 0 to 12.1% for the R3 gene and finally from 0 to 6.5% for the G4 gene. Results obtained with hierarchical clustering showed two clusters well differentiated, where the members of each cluster are cattle that had tumor, PL and AL, not allowing differentiate those two cluster by clinical stage.","palabras_clave":"Bovine Leukemia virus|pX region|Clinical stages"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1528,"idioma_id":4,"titulo":"Expression of p24 gag protein of Bovine leukemia virus in insect cells and its use in immunodetection of the disease","resumen":"Bovine leukemia is a common retroviral infection of cattle. The disease is characterized by a strong immunological response to several viral proteins, but the antibodies against p24 and gp51 are predominant. In this study, a recombinant baculovirus containing the gag gene p24 was constructed and the protein, used as antigen, analyzed by western blot and an indirect in-house rp24-ELISA test. This allowed detecting the presence of antibodies for bovine leukemia virus in a panel of cattle sera. The authentication of the protein expands its potential use for different medical applications, from improved diagnosis of the disease to source of antigens to be included in a subunit vaccine.","palabras_clave":"Bovine leukemia virus|Immunodetection|Baculovirus system|Recombinant p24 protein"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1529,"idioma_id":4,"titulo":"Phospholipase A1: a novel virulence factor in Trypanosoma cruzi","resumen":"Phospholipase A1 (PLA1) has been described in the infective stages of Trypanosoma cruzi as a membrane-bound\/secreted enzyme that significantly modified host cell lipid profile with generation of second lipid messengers and concomitant activation of protein kinase C. In the present work we determined higher levels of PLA1 expression in the infective amastigotes and trypomastigotes than in the non-infective epi-mastigotes of lethal RA strain. In addition, we found similar expression patterns but distinct PLA1 activity levels in bloodstream trypomastigotes from Cvd and RA (lethal) and K98 (non-lethal) T. cruzi strains, obtained at their corresponding parasitemia peaks. This fact was likely due to the presence of different levels of anti-T. cruzi PLA1 antibodies in sera of infected mice, that modulated the enzyme activity. More-over, these antibodies significantly reduced in vitro parasite invasion indicating the participation of T. cruzi PLA1 in the early events of parasite?host cell interaction. We also demonstrated the presence of lysophospholipase activity in live infective stages that could account for self-protection against the toxic lysophospholipids generated by T. cruzi PLA1 action. At the genome level, we identified at least eight putative genes that codify for T. cruzi PLA1 with high amino acid sequence variability in their amino and carboxy-terminal regions; a putative PLA1 selected gene was cloned and expressed as a recombinant protein that possessed PLA1 activity. Collectively, the results presented here point out at T. cruzi PLA1 as a novel virulence factor implicated in parasite invasion 1 (PLA1) has been described in the infective stages of Trypanosoma cruzi as a membrane-bound\/secreted enzyme that significantly modified host cell lipid profile with generation of second lipid messengers and concomitant activation of protein kinase C. In the present work we determined higher levels of PLA1 expression in the infective amastigotes and trypomastigotes than in the non-infective epi-mastigotes of lethal RA strain. In addition, we found similar expression patterns but distinct PLA1 activity levels in bloodstream trypomastigotes from Cvd and RA (lethal) and K98 (non-lethal) T. cruzi strains, obtained at their corresponding parasitemia peaks. This fact was likely due to the presence of different levels of anti-T. cruzi PLA1 antibodies in sera of infected mice, that modulated the enzyme activity. More-over, these antibodies significantly reduced in vitro parasite invasion indicating the participation of T. cruzi PLA1 in the early events of parasite?host cell interaction. We also demonstrated the presence of lysophospholipase activity in live infective stages that could account for self-protection against the toxic lysophospholipids generated by T. cruzi PLA1 action. At the genome level, we identified at least eight putative genes that codify for T. cruzi PLA1 with high amino acid sequence variability in their amino and carboxy-terminal regions; a putative PLA1 selected gene was cloned and expressed as a recombinant protein that possessed PLA1 activity. Collectively, the results presented here point out at T. cruzi PLA1 as a novel virulence factor implicated in parasite invasion ","palabras_clave":"Trypanosoma cruzi|Phospholipase A1|Virulence factor|Neutralizing antibodies|Lysophospholipase 21 activity|Cloning|Recombinant expression"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1533,"idioma_id":4,"titulo":"The influence of habitat, season and tidal regime in the activity of the  intertidal crab Neohelice (=Chasmagnathus) granulata.","resumen":"The activity pattern of intertidal crabs is influenced by factors that usually change rhythmically following tidal and\/or diel cycles, and is often associated with the use of refuges. The movement activity of the burrowing crab Neohelice granulata was compared among three populationsfrom SW Atlantic coastal areas where they face different tidal regimes, water salinities, substrata and biological factors. At each site, we examined the seasonal activity of the crabs (individuals collected in pitfall traps) in two types of habitat: mudfat and salt marsh. The working hypothesis is that the activity would vary according to the diverse environmental conditions encountered at geographical and local scales. Crab activity varied between sites and seasons showing to be more intense when habitats were covered by water. The most active groups were large males, followed by large non-ovigerous females. Ovigerous females were almost inactive. Most crabs were near orinside burrows at low tides in Mar Chiquita and Bahía Blanca, but they were active at both low and high tides in San Antonio during spring and summer. N. granulata were active in a wide range of temperatures: from 10 to 37 °C at low tides and at temperatures as low as 2 °C when coveredby water. Differences of activity between mudfat and salt marsh varied among sites depending on flooding frequencies. Movement activity of N. granulata varied both in space and in time; crabs move under very different abiotic conditions (e.g., low or high tide, daylight or night, low andhigh temperature) and their movement may also be prevented or elicited by biotic conditions like burrow complexity, food quality and predation pressure. The wide set of conditions under which N. granulata can be active may explain why this is the only semiterrestrial crab inhabitinglatitudes higher than 40°S in South America.","palabras_clave":"ACTIVITY PATTERN|INTERTIDAL CRAB|INTER-POPULATION DIVERGENCE|NEOHELICE GRANULATA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1535,"idioma_id":4,"titulo":"Residual stress analysis in PVD coated austempered ductile iron","resumen":"The aim of this work is to study residual stresses (RS) in PVD TiN and CrN coated ADI substrates withdifferent nodule counts, austempering temperatures and surface finishing methods (grinding and polishing).Coatings were applied by arc ion plating using an industrial reactor and different sets of processingparameters. Residual stress measurements were performed by x-ray diffraction using the sin2ø method along two principal axes on the samples surface (parallel and perpendicular to the substrate abrasiondirection). The film thickness, hardness and adhesion of each coated sample were also evaluated.The results obtained indicate that RS in TiN and CrN coated samples are compressive irrespective ofthe different substrates, surface finishing methods and processing parameters utilized. The parallel andperpendicular RS do not vary significantly, indicating a rotationally symmetric biaxial stress state. The RSof the coated samples are not influenced by the different substrate characteristics regarding microstructure,hardness and surface roughness. The microhardness and RS of TiN and CrN coated samplesincrease with film thickness. The increase in substrate temperature together with the decrease in the valuesof BIAS voltage, arc current and chamber pressure lead to microhardness and RS reduction. Grindingproduces surface hardening and reduction of the compressive RS in the substrates, but causes no variationsin the RS of the TiN and CrN coated samples. The adhesion strength quality of TiN and CrN coatingsto ADI substrates can be related to indices ranging from HF1 to HF2.along two principal axes on the samples surface (parallel and perpendicular to the substrate abrasiondirection). The film thickness, hardness and adhesion of each coated sample were also evaluated.The results obtained indicate that RS in TiN and CrN coated samples are compressive irrespective ofthe different substrates, surface finishing methods and processing parameters utilized. The parallel andperpendicular RS do not vary significantly, indicating a rotationally symmetric biaxial stress state. The RSof the coated samples are not influenced by the different substrate characteristics regarding microstructure,hardness and surface roughness. The microhardness and RS of TiN and CrN coated samplesincrease with film thickness. The increase in substrate temperature together with the decrease in the valuesof BIAS voltage, arc current and chamber pressure lead to microhardness and RS reduction. Grindingproduces surface hardening and reduction of the compressive RS in the substrates, but causes no variationsin the RS of the TiN and CrN coated samples. The adhesion strength quality of TiN and CrN coatingsto ADI substrates can be related to indices ranging from HF1 to HF2.along two principal axes on the samples surface (parallel and perpendicular to the substrate abrasiondirection). The film thickness, hardness and adhesion of each coated sample were also evaluated.The results obtained indicate that RS in TiN and CrN coated samples are compressive irrespective ofthe different substrates, surface finishing methods and processing parameters utilized. The parallel andperpendicular RS do not vary significantly, indicating a rotationally symmetric biaxial stress state. The RSof the coated samples are not influenced by the different substrate characteristics regarding microstructure,hardness and surface roughness. The microhardness and RS of TiN and CrN coated samplesincrease with film thickness. The increase in substrate temperature together with the decrease in the valuesof BIAS voltage, arc current and chamber pressure lead to microhardness and RS reduction. Grindingproduces surface hardening and reduction of the compressive RS in the substrates, but causes no variationsin the RS of the TiN and CrN coated samples. The adhesion strength quality of TiN and CrN coatingsto ADI substrates can be related to indices ranging from HF1 to HF2.2ø method along two principal axes on the samples surface (parallel and perpendicular to the substrate abrasiondirection). The film thickness, hardness and adhesion of each coated sample were also evaluated.The results obtained indicate that RS in TiN and CrN coated samples are compressive irrespective ofthe different substrates, surface finishing methods and processing parameters utilized. The parallel andperpendicular RS do not vary significantly, indicating a rotationally symmetric biaxial stress state. The RSof the coated samples are not influenced by the different substrate characteristics regarding microstructure,hardness and surface roughness. The microhardness and RS of TiN and CrN coated samplesincrease with film thickness. The increase in substrate temperature together with the decrease in the valuesof BIAS voltage, arc current and chamber pressure lead to microhardness and RS reduction. Grindingproduces surface hardening and reduction of the compressive RS in the substrates, but causes no variationsin the RS of the TiN and CrN coated samples. The adhesion strength quality of TiN and CrN coatingsto ADI substrates can be related to indices ranging from HF1 to HF2.","palabras_clave":"austempered ductile iron|TiN|CrN| PVD processing parameters|residual stresses|grinding"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1538,"idioma_id":4,"titulo":"Cosmic spherules from the Ordovician of Argentina","resumen":"The discovery of magnetic spherules in acid-insoluble residues from conodont samples encouraged a systematic search for Ordovician micrometeorites from Northwestern Argentina. Some 220 melted micrometeorites were recovered from the magnetic fraction of 6 samples (total rock weight: 23 kg) from the Cordillera Oriental (Santa Rosita Formation) and 17 from 5 samples (total rock weight: 8.9 kg) from the Argentine Precordillera (Las Aguaditas, Gualcamayo and Las Vacas formations). The specimens resemble I-type cosmic spherules, in their chemistry and distinct dendritic and polygonal crystalline structures. They represent a flux of micrometeorites several orders of magnitude greater than present. The wide differences in spherule abundance between the Precordillera and the Cordillera Oriental samples could reflect uncertainties in the sedimentary rates or temporal variations in the flux of extraterrestrial matter to Earth. The micrometeorite-bearing formations span the late Tremadocian to the late Darriliwian (~480-460 Ma), which is consistent with a period of elevated flux of extraterrestrial material, as recorded several thousand kilometres away from coeval horizons in Scotland, Sweden and central China.&nbsp;","palabras_clave":"MICROSPHERULES|COSMIC DUST|ORDOVICIAN|CORDILLERA ORIENTAL|PRECORDILLERA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1541,"idioma_id":4,"titulo":"Spectroscopic slicing to reveal internal redox gradients in electricity-producing biofilms","resumen":"Wired-up bacteria: Confocal Raman microscopy in combination with 3D structural analysis is used in the measurement of redox gradients in electricity-producing biofilms in&#8197;vivo. The approach provides new relevant information for the understanding of electron conduction mechanisms in these systems.","palabras_clave":"BIOFILMS|ELECTRON CONDUCTION|RAMAN SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1542,"idioma_id":4,"titulo":"Linking reproductive and feeding strategies in the parasitoid Ibalia leucospoides: Does feeding always imply profit?","resumen":"Resource acquisition and allocation to different biological functions over the course of life have strong implications for animal  reproductive success. Animals can experience different environmental conditions during their lifetime, and this may play an important role in shaping their life-history and resource allocation strategies. In this study we investigate larval and adult resource allocation to reproductive and survival functions in the parasitoid wasp Ibalia leucospoides (family Ibaliidae). The pattern of larval resource allocation was inferred from the relationship between adult body size and ovigeny index (OI; a relative measure of investment in early reproduction determined as the ratio between the initial egg load and the potential lifetime fecundity); and adult resource allocation was explored through the influence of adult feeding on reproduction, maintenance and metabolism, in laboratory experiments. Food acquisition by this parasitoid in the wild was also examined. The relationship between size and OI was constant, suggesting no differential resource allocation to initial egg load and potential lifetime fecundity with size. This finding is in line with that predicted by adaptive models for the proovigenic egg maturation strategy (OI = 1). Despite of this, I. leucospoides showed a high OI of 0.77, which places this species among the weakly synovigenic ones (OI). Adult feeding had no effect on post-emergence egg maturation. However, wasps extended their lifespan through feeding albeit only when food was provided ad libitum. Although the information we obtained on the feeding behaviour of free-foraging wasps is limited, our results suggest that food intake in the wild, while possible, may not be frequent in this parasitoid. We discuss the results relative to the environmental factors, such as reproductive opportunities and food availability, which may have driven the evolution of larval and adult pattern of resource allocation in parasitoids.","palabras_clave":"HYMENOPTERA|LIFE HISTORY TRAITS|OVIGENY INDEX|PARASITOID FEEDING BEHAVIOR|RESOURCE ALLOCATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1543,"idioma_id":4,"titulo":"Deacidification and solvent recovery of soybean oil by nanofiltration membranes","resumen":"Four tailor-made flat composite membranes of poly(vinylideneflouride) (PVDF) as a support and polydimethylsiloxane (PDMS) or cellulose acetate (CA) as coating layer, and a commercially available composite membrane (Solsep 030306) were used to remove hexane and free fatty acid (FFA) from crude soybean oil-hexane mixture. The effects of transmembrane pressure (&#916;p=10-20 bar), temperature (T=30-50ºC) and feed oil concentration Cf=10-35 w\/w %) on membrane selectivity and permeation flux were determined. The PVDF-12% siloxane composite nanofiltration membrane achieved the best results, being stable in commercial hexane and having promising permselectivity properties to separate soybean oil\/hexane miscella. Improved separation performance was obtained at Cf = 25%, &#916;p = 20 bar, and T = 30°C, achieving a permeate flux of 20.3 Lm-2h-1,80% oil retention, 58% FFA removal","palabras_clave":"Nanofiltration|Polymeric Membrane|Soybean Oil|Solvent Recovery"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1544,"idioma_id":4,"titulo":"Plasmon-induced photochemical synthesis of silver triangular prisms and pentagonal bipyramids by illumination with light emitting diodes","resumen":"We have grown silver prisms and pentagonal bipyramids, induced by plasmon excitation on a  colloidal solution under the irradiation of light emitting diodes of different colors. Two methods of  synthesis of the seeds were tested and their growth evolution recorded, in order to analyze the effect of  the chemical synthesis and the color of the irradiation on the morphology and size of the final product.  We show that the conversion rate into anisotropic nanoparticles is determined by the chemical  environment and the shift of the irradiation wavelength with respect to the plasmon resonance of the  seeds. The conversion rate defines the final morphology of the nanoparticles, whereas the size of the  nanoparticles is univocally determined by the wavelength of irradiation, irrespective of the method to  prepare the seed solution.","palabras_clave":"Metals|Nanostructures|Chemical synthesis|optical properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1546,"idioma_id":4,"titulo":"Density estimation for spatial temporal models","resumen":"In this paper a k-nearest neighbor type estimator of the marginal density function for a random field which evolves with time is considered. Considering dependence, the consistency and asymptotic distribution are studied for the stationary and nonstationary cases. In particular, the parametric rate of convergence &#8730;T is proven when the random field is stationary. The performance of the estimator is shown by applying our procedure to a real data example.","palabras_clave":"Density estimation|Local times|spatio-temporal data"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1548,"idioma_id":4,"titulo":"Measurements of top quark pair relative differential cross-sections with ATLAS in pp collisions at &#8730; s = 7 TeV","resumen":"Measurements are presented of differential cross-sections for top quark pair production in pp collisions at s&#8730;=7 TeV relative to the total inclusive top quark pair production cross-section. A data sample of 2.05 fb&#8722;1 recorded by the ATLAS detector at the Large Hadron Collider is used. Relative differential cross-sections are derived as a function of the invariant mass, the transverse momentum and the rapidity of the top quark pair system. Events are selected in the lepton (electron or muon) + jets channel. The background-subtracted differential distributions are corrected for detector effects, normalized to the total inclusive top quark pair production cross-section and compared to theoretical predictions. The measurement uncertainties range typically between 10 % and 20 % and are generally dominated by systematic effects. No significant deviations from the Standard Model expectations are observed.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1549,"idioma_id":4,"titulo":"Measurement of the flavour composition of dijet events in pp collisions at &#8730; s = 7 TeV with the ATLAS detector","resumen":" This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at sqrt{s}=7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39 pb^-1. Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40 GeV to 500 GeV and jet rapidity |y| &lt; 2.1. The fit results agree with the predictions of leading- and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e.g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions.","palabras_clave":"ATLAS|LHC|HEP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1550,"idioma_id":4,"titulo":"Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqrt(s) = 7 TeV proton-proton collision data","resumen":"A search for squarks and gluinos in final states containing jets, missing transverse momentum and no high-pT electrons or muons is presented. The data represent the complete sample recorded in 2011 by the ATLAS experiment in 7 TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 4.7&#8201;&#8201;fb-1. No excess above the Standard Model background expectation is observed. Gluino masses below 860 GeV and squark masses below 1320 GeV are excluded at the 95% confidence level in simplified models containing only squarks of the first two generations, a gluino octet and a massless neutralino, for squark or gluino masses below 2 TeV, respectively. Squarks and gluinos with equal masses below 1410 GeV are excluded. In minimal supergravity\/constrained minimal supersymmetric Standard Model models with tan&#946;=10, A0=0 and &#956;>0, squarks and gluinos of equal mass are excluded for masses below 1360 GeV. Constraints are also placed on the parameter space of supersymmetric models with compressed spectra. These limits considerably extend the region of supersymmetric parameter space excluded by previous measurements with the ATLAS detector.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1551,"idioma_id":4,"titulo":"The diet of Olrog's Gull  (Larus atlanticus) reveals an association with fisheries during the non-breeding season","resumen":"In this study, we used stable-isotope analysis to determine the importance of different food resources in the diet of an endemic gull species of the Atlantic coast of southern South America during the non-breeding period.Wecompared the isotopes 15Nand 13Cin the blood of Olrog\u2019s Gulls (Larus atlanticus) of different ages with those in potential prey of the Gulls. We also determined the abundance of Olrog\u2019s Gull in their wintering areas and attending coastal fisheries operations in a small region of Argentina. An isotope-mixing model showed differences in the isotopic signatures of adult, subadult and juvenile Gulls. Although the isotope-mixing model showed crabs as the main prey, it also showed that demersal and pelagic fishmaybe important in the diet.Wespeculate that the demersal and pelagic fish in the diet, shown by their isotopic signaturesin the Gulls, may be taken in association with coastal fisheries, particularly bottom otter-paired trawling. At-sea observationsshowed that Olrog\u2019s Gulls were one of the most-common birds attending fishing operations of the Argentine coastal fishing fleet, taking advantage of fish mostly made available through hauling operations.","palabras_clave":"dietary habits|stable-isotopes|assocoation with fisheries"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1552,"idioma_id":4,"titulo":"Effect of thermal fluctuations in FMR experiments in uniaxial magnetic nanoparticles : blocked vs superparamagnetic regimes","resumen":"We present ferromagnetic resonance (FMR) experiments on two low-interacting nanoparticle systems: Fe3O4and CoFe2O4corresponding to low- and high-anisotropy cases, respectively. The spectra have been interpreted in terms of a phenomenological model which applies to the FMR of nanoparticles. The model includes the effect of thermal fluctuations in the FMR covering the range from the superparamagnetic (low-anisotropy-high-temperature) regime to the high-anisotropy-low-temperature situation. We have been able to explain several simultaneous features observed in the FMR spectra of a system of anisotropic nanoparticles when lowering the temperature that include: a decrease of the resonance field with a simultaneous linewidth increase and intensity reduction. These effects had been previously attributed to the existence of a 'blocking-temperature' in the FMR. Our interpretation, however, shows that in a magnetic system with easy axes this FMR response originates in the temperature dependence of the dispersion relation. Also, applying the present model to the FMR within the hysteresis cycle it is possible to reproduce the irreversibilities occurring in the resonance spectra. Comparison of FMR and magnetization measurements show that the characteristic FMR time is notrelated to the inverse microwave frequency.&nbsp;","palabras_clave":"Resonance|magnetic nanoparticles |blocked regime|superparamagnetic regime"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1553,"idioma_id":4,"titulo":"Heat generation in agglomerated ferrite nanoparticles in an alternating magnetic field","resumen":"The role of agglomeration and magnetic interparticle interactions in heat generation of magnetic ferrofluids in an ac magnetic field is still unclear, with apparent discrepancy between the results presented in the literature. In this work, we measured the heat generating capability of agglomerated ferrite nanoparticles in a non-invasive ac magnetic field with f=100 kHz and H0 =13 kA\/m. The nanoparticles were morphologically and magnetically characterized, and the specific absorption rate (SAR) for our ac magnetic field presents a clear dependence on the diameter of the nanoparticles, with a maximum SAR=48W\/g for 15 nm. Our agglomerated nanoparticles have large hydrodynamic diameters, thus the mechanical relaxation can be neglected as a heat generation mechanism. Therefore, we present a model that simulates the SAR dependence of the agglomerated samples on the diameter of the nanoparticles based on the hysteresis losses that is valid for the non-linear region (withH0comparable to the anisotropy field). Our model takes into account the magnetic interactions among the nanoparticles in the agglomerate. For comparison, we also measured the SAR of non-agglomerated nanoparticles in a similar diameter range, in which Neel and Brown relaxations dominate the heat generation. ","palabras_clave":"MAGNETIC NANOPARTICLES|HEATING GENERATION MECHANISM|MAGNETIC INTERACTION|HYPERTHERMIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1554,"idioma_id":4,"titulo":"Seabird and marine-mammal attendance and by-catch in semi-industrial trawl fisheries in near-shore waters of northern Argentina","resumen":"Seabird and marine-mammal attendance and by-catch in mid-water and bottom otter semi-industrial coastal pair-trawl fisherieswere assessed for the first time in northern Argentina. Observers were placed onboard trawlers between autumn 2007 and autumn 2008. Fifteen marine top-predator species were associated with the vessels. The most abundant and frequent seabirds (trawl fisheries combined) were the kelp gull, Larus dominicanus (,70% of total birds and .96% occurrence), and the Olrog\u2019s gull, L. atlanticus (12% and .50%, respectively). Other seabird taxa such as Procellariiforms and Sphenisciforms, among others, were represented in very low numbers. The only mammal species recorded was the South American sea lion, Otaria flavescens (1% and 2%, respectively). Analysis of environmental and operational variability affecting the abundance of gulls indicated a significant increase in abundance with fishing depth, time of day, seasonality, wind intensity and wind direction. Incidental mortality of top predators was low and comprised only Magellanic penguins, Spheniscus magellanicus, in the mid-water gear. The results of the present study showed that the semi-industrial trawl fisheries operating in coastal waters in northern Argentina may a have a relatively minor impact on marine top-predator populations, at least in terms of incidental capture.","palabras_clave":"FISHERY-TOP PREDATOR INTERACTIONS|PAIR-TRAWL COASTAL FISHERIES|MARINE TOP PREDATORS|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1555,"idioma_id":4,"titulo":"New insights into antibacterial and antioxidant activities of rosemary essential oils and their main components","resumen":"Rosemary essential oils constituents were investigated by GC-FID-MS. Microbiological analysis using the disk diffusion and microplate bioassay as well as fluorimetric approaches by SYTOX Green stain to study bacterial membrane permeabilization were performed. The antibiotic activity of rosemary oils containing &#945;-pinene, myrcene, 1,8-cineole, borneol and camphor as major constituents, was lower than the activity of pure constituents displaying minimal inhibition concentration, MIC, 10 to 25 &#956;l ml-1 and 0.8 to 8 &#956;l ml-1, respectively. &#945;-Pinene is the main bioactive showing the broadest activity against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli. 1,8-cineole was bactericidal on E. coli trough the cell membrane permeabilization, effect that it was demonstrated for the first time using a fluorimetric analysis.","palabras_clave":"Antibacterial activity|Essential oil|Rosemary|alpha-Pinene"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1557,"idioma_id":5,"titulo":"Gestión del Proceso de Desarrollo de Productos para PyMes Productoras de Fármacos","resumen":"La Gestión del Proceso de Desarrollo de Productos (PDP) conlleva la realización de un conjunto de actividades, en las que debe intervenir la mayoría de las áreas funcionales de la organización productiva. Cada una de ellas, se lleva a cabo teniendo en cuenta el producto a desarrollar, la capacidad productiva, la estrategia comercial y la concepción filosófica de la empresa.   En el presente trabajo se propone un modelo de Gestión del Proceso de Desarrollo de Productos para Pequeñas y Medianas Empresas Productoras de Fármacos, teniendo en cuenta el modelo referencial de Rozenfeld y los parámetros característicos de las empresas nacionales del sector. El modelo de gestión diseñado se lleva a cabo con la finalidad de mejorar los procedimientos realizados en el desarrollo de productos, considerando la estructura organizacional de las empresas, de manera que se ajuste, adapte y sea aceptado por los diferentes actores involucrados en el PDP. Además, el modelo de gestión se elabora en términos de ambiente competitivo, estrategias y capacidades de las empresas, presentando los conceptos, herramientas y flujo de información aplicados en las diversas actividades para la comprensión y traducción de los requisitos de los clientes, mejorando las especificaciones del producto, de su proceso de producción y seguimiento. En el presente trabajo se propone un modelo de Gestión del Proceso de Desarrollo de Productos para Pequeñas y Medianas Empresas Productoras de Fármacos, teniendo en cuenta el modelo referencial de Rozenfeld y los parámetros característicos de las empresas nacionales del sector. El modelo de gestión diseñado se lleva a cabo con la finalidad de mejorar los procedimientos realizados en el desarrollo de productos, considerando la estructura organizacional de las empresas, de manera que se ajuste, adapte y sea aceptado por los diferentes actores involucrados en el PDP. Además, el modelo de gestión se elabora en términos de ambiente competitivo, estrategias y capacidades de las empresas, presentando los conceptos, herramientas y flujo de información aplicados en las diversas actividades para la comprensión y traducción de los requisitos de los clientes, mejorando las especificaciones del producto, de su proceso de producción y seguimiento.","palabras_clave":"Nivel de Madurez|Desarrollo de Fármacos|PyMEs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1558,"idioma_id":5,"titulo":"Niveles de Madurez de la Gestión del Proceso de Desarrollo de Productos en PyMes Productoras de Fármacos","resumen":"Las prácticas relacionadas con la Gestión de Proceso de Desarrollo de Productos (PDP) dependen del nivel de madurez de las empresas, por lo tanto es necesario conocer en qué estadío del PDP se encuentran las mismas, para incorporar mejoras en dicho proceso de modo que resulte más eficiente.  En el presente trabajo se realiza el diagnóstico del nivel de madurez de la Gestión del PDP en PyMEs regionales productoras de fármacos. Para ello, se lleva a cabo una investigación exploratoria en empresas productoras de fármacos, radicadas en la región Litoral-Centro, con el objetivo de recopilar información relacionada con la forma en que efectúan la Gestión del PDP (actividades, informaciones, recursos y organización). Para tal fin, se utilizan sistemas de entrevistas, registros de actividades y observación in situ. Las preguntas de los cuestionarios se dividen en 3 grupos: (i) información general de la empresa, (ii) información sobre los procedimientos relacionados con la Gestión del PDP, (iii) información sobre las dificultades encontradas en la Gestión del PDP. Luego, se sistematiza y analiza la información recolectada. A partir de ello, se determina que las PyMEs entrevistadas poseen un nivel de madurez básico, considerando la escala sugerida por Rozenfeld, en lo que respecta a la Gestión del PDP. En este nivel, las empresas realizan sistemáticamente un conjunto de prácticas esenciales para la gestión eficaz del PDP, tales como: (i) la integración con la alta gerencia, (ii) la definición de un alcance detallado del proyecto y (ii) la definición e implementación de los requisitos.","palabras_clave":"NIVELES DE MADUREZ|DESARROLLO DE FÁRMACOS|PYMES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1559,"idioma_id":4,"titulo":"A fast and accurate method to solve the incompressible Navier-Stokes equations","resumen":"Purpose \u2013 The purpose of this paper is to highlight the possibilities of a novel Lagrangian formulation in dealing with the solution of the incompressible Navier-Stokes equations with very large time steps.  Design\/methodology\/approach \u2013 The design of the paper is based on introducing the origin of this novel numerical method, originally inspired on the Particle Finite Element Method (PFEM), summarizing the previously published theory in its moving mesh version. Afterwards its extension to &#64257;xed mesh version is introduced, showing some details about the implementation.  Findings \u2013 The authors have found that even though this method was originally designed to deal with heterogeneous or free-surface &#64258;ows, it can be competitive with Eulerian alternatives, even in their range of optimal application in terms of accuracy, with an interesting robustness allowing to use large time steps in a stable way.  Originality\/value \u2013 With this objective in mind, the authors have chosen a number of benchmark examples and have proved that the proposed algorithm provides results which compare favourably, both in terms of solution time and accuracy achieved, with alternative approaches, implemented in in-house and commercial codes.","palabras_clave":"FLUIDS|FLOW|FLUID DYNAMICS|NAVIER-STOKES EQUATIONS|PARTICLE METHODS|LARGE TIME-STEPS|INCOMPRESSIBLE FLUID FLOWS|UPDATED LAGRANGIAN FORMULATIONS|REAL TIME CFD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1560,"idioma_id":4,"titulo":"A FFT Preconditioning Technique for the Solution of Incompressible Flow on GPU's","resumen":"Graphic Processing Units have received much attention in last years. Compute-intensive algorithms operating on multidimensional arrays that have nearest neighbor dependency and\/or exploit data locality can achieve massive speedups. Simulation of problems modeled by time- dependent Partial Differential Equations by using explicit time-stepping methods on structured grids is an instance of such GPU-friendly algorithms. Solvers for transient incompressible fluid flow cannot be developed in a fully explicit manner due to the incompressibility constraint. Segregated algorithms like the fractional step method require the solution of a Poisson problem for the pressure field at each time level. This stage is usually the most time-consuming one. This work discuss a solver for the pressure problem in applications using immersed boundary techniques in order to account for moving solid bodies. This solver is based on standard Conjugate Gradients iterations and depends on the availability of a fast Poisson solver on the whole domain to define a preconditioner. We provide a theoretical and numerical evidence on the advantages of our approach versus classical techniques based on fixed point iterations such as the Iterated Orthogonal Projection method.","palabras_clave":"GPU|CFD|Navier-Stokes|FFT Poisson solver"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1561,"idioma_id":4,"titulo":"Influence of underwater light climate on periphyton and phytoplankton communities in shallow lakes from the Pampa Plain (Argentina) with contrasting steady states","resumen":"Shallow lakes from the Pampa plain (Argentina) are subjected to the impact of different human activities, and as a consequence,  most of them are in a turbid state. Three types of shallow lakes have been described in this region: clear-vegetated, phytoplanktonturbid  and inorganic-turbid. We analysed the periphyton and phytoplankton structure in five selected shallow lakes with contrasting  optical characteristics. In the case of periphyton, we studied the variation in depth. Pigment compositions of both algal communities  were analysed by means of high-performance liquid chromatography. Additionally, we studied the taxonomic algal composition of both  communities and the mass variables of periphyton. We observed a general decreasing pattern in the mean values of periphytic abundance  with depth, and stratification in periphyton was generally consistent with the vertical profiles of pigments. Relationships between cell  counts and pigments also suggested changes in the intracellular pigment concentration due to photoacclimation. In clear lakes, surface  periphytic communities were co-dominated by chlorophytes and diatoms. In turbid lakes the surface assemblages were mainly represented  by diatoms and the relative contribution of cyanobacteria increased with depth. The interaction between light and nutrients in  different turbid scenarios may explain the patterns observed in the development of the periphytic community. We observed lower periphyton  accrual in lakes that presented boundary values in the restrictions of either nutrients or light availability. In phytoplanktonturbid  lakes, periphyton exhibited a considerable growth due to the rich nutrient conditions, but the community was dominated by the  heterotrophic fraction and we also found algal groups well adapted to light limitation.","palabras_clave":"PERIPHYTON|PHYTOPLANKTON|PIGMENT COMPOSITION|CLEAR AND TURBID SHALLOW LAKES|HPLC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1562,"idioma_id":5,"titulo":"Análisis estructural y funcional de proteínas solubles que unen lípidos de intestino e hígado","resumen":"Luego de la ingesta, el epitelio del intestino delgado está encargado de asimilar grandescantidades de nutrientes, como aminoácidos, glúcidos y ácidos grasos. Las proteínassolubles que unen lípidos cumplirían un rol determinante en este proceso, sobretodoprotegiendo la integridad del tejido contra el efecto simil-detergente de los ácidos grasosprovenientes de la dieta. En enterocitos se expresan dos proteínas que unen ácidos grasoscadena larga, IFABP y LFABP, para las cuales no se conocen bien aún sus funcionesespecíficas, o el porqué de la necesidad de dos proteínas aparentemente equivalentes.Nuestro laboratorio se ha enfocado en el estudio comparativo de estas dos proteínasempleando distintas variantes estructurales y métodos bioquímicos, biofísicos, y de biologíamolecular y celular. Así, se ha podido definir los determinantes moleculares de cadaproteína responsables de la interacción con membranas, los mecanismos de transferencialigandos y los factores que modulan estas propiedades. Más recientemente, hemosextendido estos ensayos a cultivos celulares donde correlacionamos la expresión de estasproteínas con la secreción de citoquinas, la proliferación y la diferenciación celular. Elestudio de estas proteínas es de gran importancia por su potencial como blancosterapéuticos y su utilidad en el diagnóstico de injurias tisulares.","palabras_clave":"Proteínas Solubles que Unen Lípidos|Metabolismo de Ácidos Grasos|Epitelio intestinal|Fluorescencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1564,"idioma_id":5,"titulo":"INTEGRACION TECNOLOGICA EN UNA VIVIENDA PROGRESIVA SUSTENTABLE","resumen":"LA VIVIENDA PROGRESIVA SUSTENTABLE INTEGRA ASPECTOS RELATIVOS AL DISEÑO, TECNOLOGÍA, PRODUCCIÓN, FINANCIAMIENTO, CAPACITACION Y SUSTENTABILIDAD.  ES UNA VIVIENDA SOCIAL QUE SINTETIZA TRES CONCEPTOS FUNDAMENTALES: DENSIFICACION DEL USO DEL SUELO, MODELOS DE GESTION Y TECNOLOGIAS Y COMPONENTES CONSTRUCTIVOS SUSTENTABLES.","palabras_clave":"VIVIENDA |SUSTENTABLE|PROGRESIVA|PRODUCCION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1567,"idioma_id":4,"titulo":"Innovative Methodology to Use Renewable Energy for Engineering Learning Application","resumen":"This work is based on a methodology to develop and optimize Renewable Energy (RE) applications in Neuquén Province, Argentina. The first stage is to determine the location of RE project and then select the sources which are relevant in energy production. With this information, RE converters conceptual design is made. Then, the proper converter is chosen with the calculated power module and preliminary unit commitment according to the energy demand. The alternative with less environmental, health impact and most social and economical impact analyzing the life Cycle of the Power plant is chosen. Holistical Methodology is used for managing the project and avoided CO2 is calculated by means of Clean Development Mechanism. Green Bonus can be offered when the Power station will begin in operation. The example presented in this work is the Power Station as Renewable Energy School Application (RESPS) in Engineering Faculty, National University of Comahue (EFUNCo), Argentina. Research Groups (RG) of EFUNCo are developing this kind of project including students as volunteers for design, manufacturing, installation and maintenance of Wind, Micro-Hydro, Biomass and Solar devices for several kind of Social and Energy applications in Patagonia. These RG decide on 2010 to work together, forming a Centre of Renewable Energy Sources Analysis to develop the RESPS and other RE projects.","palabras_clave":"CO2 AVOIDED|RENEWABLE ENERGY|HOLISTICALLY METHOD|SCHOOL POWER STATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1568,"idioma_id":4,"titulo":"Expression and localization of nodal in bovine oviduct and uterus during different functional stages of oestrus cycle and pregnancy","resumen":"Members of TGF-&#946; superfamily play a major role in the endometrial changes involved in the establishment and maintenance of pregnancy. Their deregulated expression and action could lead to absolute or partial failure of embryo implantation. Nonetheless, the precise function and mechanism of many of these cytokines remain unclear. Nodal, a transforming growth factor beta (TGF-&#946;) superfamily member, was characterized in the human and rodent uterus and implicated in the tissue remodeling events during menstruation and embryo implantation. In order to study its possible role in the cattle reproductive process, we have analyzed Nodal expression pattern and localization in the oviduct and uterine horn during the oestrus cycle and early pregnancy (day 20). Nodal was detected both in oviduct and uterus during either the oestrus cycle or pregnancy; however, it shows a differential expression profile in the uterine horn at dioestrus and pregnancy, decreasing 1.5 and 1.4 folds in comparison with oestrus. Nodal immunostaining intensity was observed in stromal and in epithelial cells of the surface and the glandular epithelium. The staining pattern correlates with the RT-qPCR expression profile. This work is the first to evidence the presence of Nodal in the bovine reproductive tract; our data suggest that Nodal is a novel cytokine that would be involved in the remodelling occurring in the endometrium of cattle during the oestrus cycle and in the embryo implantation. The identification of new molecules that participate in endometrium cycling and\/or pregnancy may be useful for predicting the ability of the uterine tissue to establish and maintain pregnancy or for detecting the infertility processes. These results highlight Nodal as a possible novel marker of the fertility process, nevertheless further studies should be done to determine its role in the reproductive system.","palabras_clave":"EMBRYO|IMPLANTATION|NODAL|PREGNANCY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1570,"idioma_id":4,"titulo":"A characterization of edge-perfect graphs and the complexity of recognizing some  combinatorial optimization games","resumen":"We characterize edge-perfect graphs and prove that it is co-NP-complete to recognize them. In consequence, recognizing the defining matrices of totally balanced packing games is also co-NP-complete,   in contrast with the polynomiality for the covering case. In addition,   we solve the computational complexity of universally balanced (with   respect to the resources constraints) packing games.","palabras_clave":"Edge perfect|Graph|Totally balanced game| NP-completeness"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1571,"idioma_id":4,"titulo":"SYNTHESIS OF Pd \/Al2O3 COATING ONTO A CORDIERITE MONOLITH AND ITS APPLICATION TO NITRITE REDUCTION IN WATER","resumen":"The catalytic properties of Pd\/Al2O3 coating onto cordierite monolith channels for the nitrite reduction in water were studied. This coating was synthesized producing an alumina layer via washcoat and adding the palladiumspecies to this layer by immersion into a PdCl2 solution.Different characterization techniques, XRD, XPS, SEMand EDXwere used to study the physicochemical andmorphological properties of the catalytic coatings. The comparison of these results alongwith the catalytic behaviors allowed comprehension of Pd active sites and theirway of acting. The structured catalyst so obtained was active and stable in the nitrite reduction.","palabras_clave":"MONOLITH|NITRITE|REDUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1572,"idioma_id":4,"titulo":"Toughness distribution in complex PP\/nanoclay injected mouldings","resumen":"The fracture performance of PP?nanoclay box-like injection mouldings obtained in double gated mould and by direct compounding of PP and a PP-based masterbatch was studied. Samples were observed by polarised light microscopy and characterised by DSC. Other samples were fractured using mode I double edge-notched tensile specimens. Their typically brittle fracture did not show neat in-plane crack propagation.  The initial crack was branched and deviated out of the plane normal to the applied stress, and the fracture no longer followed the simple mode I. There is a tendency towards increasing the ductility and the deformation at break with the increase in nanoclay content. The fracture initiation does not depend on the nanoclay content or on the test piece location; nanoclay reinforcement increases the energy propagation  release rate, Gcp, away from the weld line. The results allow the proposal of a model for the micromechanisms acting in samples which in-turn depends on nanoparticle orientation.","palabras_clave":"Nanoclays|Polymermatrix composites (PMCs)|Fracture toughness|Injection moulding"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1574,"idioma_id":5,"titulo":"The Scelidotheriine Proscelidodon (Xenarthra: Mylodontidae) from the Late Miocene of Maimará (Northwestern Argentina)","resumen":"Xenarthra constitutes one of the most peculiar clades of the South American mammalian fauna and includes sloths (Tardigrada), anteaters (Vermilingua), and armored xenarthrans (Cingulata). Its phylogenetic affinities among placental mammals and their origins remain doubtful (Asher and Helgen, 2010). Xenarthrans first appear in the Itaboraian age (late Paleocene\u2013early Eocene; Oliveira and Goin, 2011) represented by the Dasypodidae in the locality of Itaboraí, Brazil. Sloths are first recorded from the early Oligocene (Tinguirirican age) of Chile and became abundant during the late Oligocene (Deseadan age), mainly in Argentina and Bolivia with representation of Mylodontidae and Megalonychidae (Pujos et al., 2012).","palabras_clave":"LATE MIOCENE|MAIMARA|JUJUY|SCELIDOTHERIINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1576,"idioma_id":4,"titulo":"DETERMINANTS OF PERFORMANCE IN MICRO-ENTERPRISES: PRELIMINARY EVIDENCE FROM ARGENTINA","resumen":"This paper proposes a theoretical multi-level framework that studies the determinants of micro-enterprises? performance. Using a unique data set of nearly 300 micro-enterprises located in Argentina, we find that human capital (proxied by educational level and degree of dedication), innovation and intensity of use of own capital are important determinants of the micro-enterprise?s performance. Moreover, we found that public policies give support primarily to micro-enterprises arising from unemployment. Additionally, these firms were found to be relatively less successful in terms of their performance, suggesting a pro-poor bias. Finally, we provide a taxonomy of micro-enterprises which distinguishes four different micro-entrepreneurial profiles.","palabras_clave":"MICRO-ENTERPRISES|FINANCIAL PERFORMANCE|POVERTY ALLEVIATION|PUBLIC POLICY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1577,"idioma_id":4,"titulo":"Phenanthrene degradation and strategies to improve bioavailability by microorganisms isolated from brackish sediments","resumen":"Samborombón Bay, Argentina, is a highly productive area exposed to chronic contamination, including  polycyclic aromatic hydrocarbons. Four phenanthrene-degrading strains were isolated from sediments  collected in this area. Analysis of partial 16S rRNA sequencing and a BLAST search indicated that three of  the strains belong to genus Pseudomonas and one to Sphingomonas. All the strains were able to grow in  150 mg l1 phenanthrene as the sole carbon and energy source, with high degradation efficiency (75  e100% in 72e168 h). Growth in sodium salicylate indicated that the Pseudomonas strains used this  pathway to degrade phenanthrene.  Strategies that may enhance substrate bioavailability, such as surfactant production and chemotactic  responses, were tested. Two Pseudomonas strains showed significant production of surface-active  compounds, and a strong chemotactic response toward phenanthrene. Together with the ability to  consume the supplied phenanthrene to completion, these characteristics make the mentioned strains  good candidates for bioremediation strategies intended to clean up polluted areas.","palabras_clave":"Bioremediation|Chemotaxis|Biosurfactant|Polycyclic aromatic hydrocarbon"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1579,"idioma_id":4,"titulo":"The importance of native and exotic plant identity and dominance on decomposition patterns in mountain woodlands of central Argentina","resumen":"Exotic species can have a strong influence on ecosystem processes, especially when exotic  invaders differ from natives in key morpho-functional features. We explored whether exotic species, especially those forming monospecific patches in Chaco montane woodlands, differ from natives in leaf attributes and decomposability. We then evaluated how exotic monospecific patches in that region alter litter  decomposability, by weighting leaf trait values  and decomposability by species abundance in the communities. In general, native and exotic  species from Córdoba Chaco montane woodlands did not differ in leaf attributes (specific leaf area, leaf toughness, and leaf water content), or decomposability. Because of similar trait values and decomposability, we expected to find no differences in litter decomposability between plots dominated by exotic species and those of Native woodland. However, individual species decomposability weighted by species abundance in the communities showed that litter from exotic monospecific plots had slower decomposition than native ones. This pattern was confirmed by the higher decomposability and higher quality of the naturally mixed litter collected from native plots, compared to those collected from exotic plots. Despite the general similarities between most native and exotic species inhabiting Chaco montane woodlands, the overwhelming dominance of some exotic invaders in monospecific stands (and the consequent weight of their attributes on the litter each woodland produces) might be driving differences in decomposition patterns between woodland types. Our results indicate that when estimating the impact of exotic species on ecosystem processes, we should include their relative abundance in the community, as well as the relevance of the traits influencing those processes. Otherwise, we may draw erroneous conclusions.","palabras_clave":"ALIEN SPECIES|LIGUSTRUM LUCIDUM|GLEDITSIA TRIACANTHOS|PINNUS ELLIOTTII"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1580,"idioma_id":5,"titulo":"Arqueología del Holoceno medio y tardío en Patagonia meridional: poblamiento humano y fluctuaciones climáticas","resumen":"Este trabajo busca generar un aporte al conocimiento de la dinámica poblacional de cazadores, en Patagonia meridional, durante el Holoceno medio y tardío en el marco de condiciones climáticas altamente fluctuantes. A tal fin, se analizaron distintas líneas de evidencia arqueológicas provenientes de diferentes ambientes del centro-oeste de la provincia de Santa Cruz, Argentina. Se identificó una interesante variabilidad del registro arqueológico, en estrecha relación con las modificaciones ambientales registradas en el Holoceno.","palabras_clave":"Patagonia|Cazadores Recolectores|Holoceno"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1581,"idioma_id":5,"titulo":"Evolución paleoambiental de cordones litorales holocenos durante un cortejo de caída del nivel del mar (fsst) en la Bahía Samborombón, Buenos Aires, Argentina","resumen":"Resumen: las grandes fluctuaciones climáticas cíclicas ocurridas durante el  Cuaternario tuvieron un efecto muy marcado en las regiones costeras, afectando  principalmente el ambiente geomorfológico y la sedimentación de los depósitos allí  acumulados. El mejor entendimiento de los sistemas depositacionales litorales generados en  el pasado más reciente representa una herramienta fundamental para reconstruir y  comprender otros depósitos similares del registro geológico, así como para desarrollar  predicciones sobre posibles escenarios de cambios climáticos futuros. En el área costera de  la Bahía Samborombón, noreste de la provincia de Buenos Aires, se encuentran  preservados excelentes depósitos litorales acumulados con posterioridad al último máximo  glacial, durante la transgresión holocena. Sobre la base del análisis de facies se  reconocieron cinco unidades de acumulación: cordón arenoso, cordón bioclástico, depósitos  de sobrelavado, planicie de mareas y albufera. El análisis arquitectural y la jerarquización  de superficies de discontinuidad permitieron elaborar un modelo de acumulación dinámico  de los cordones de playa y ambientes asociados en diferentes etapas durante el Holoceno  (ca. 8000 A.P.-presente). El análisis estratigráfico secuencial permitió establecer la  interacción de dos controles alocíclicos predominantes: eustático (regresión forzada) y  climático (óptimo climático del Holoceno medio). La interacción de ambos factores  extrínsecos no sólo condicionó la acumulación y amalgamación de geoformas  cordoniformes, sino también, la relación entre aporte terrígeno y productividad carbonática  de los depósitos.","palabras_clave":"Cordones de Conchilla |Estratigrafía sequencial|Óptimo climático Cuaternario |Aporte terrígeno\/productividad carbonática"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1582,"idioma_id":4,"titulo":"Temporal evolution of 137Cs+, K+ and Na+ in fruits of South American tropical species","resumen":"Concentrations of 137Cs, K and Na in fruits of lemon (Citrus limon B.) are presented. &#9658; Concentrations of K and Na in fruits of coconut (Cocos nucifera L.) are also showed. &#9658; We investigated the use of 137Cs as a tracer for the plant absorption of macronutrients. &#9658; A model was developed to simulate the temporal evolution of 137Cs, K and Na by fruits. &#9658; This model exhibited close agreement with our results along the fruit development.","palabras_clave":"VEGETAL MACRONUTRIENTS|137Cs|K+|Na+|CITRUS LIMON|COCOS NUCIFERA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1584,"idioma_id":4,"titulo":"Benzalkonium chloride breaks down conjunctival immunological tolerance in a murine model","resumen":"The impact of topical eye drops with benzalkonium chloride (BAK) as a   preservative could involve more than the reported toxic effects on the   ocular surface epithelium and ultimately affect the immune balance of   the conjunctiva. We found that BAK not only impairs tolerance induction   in a murine model, but leads to mild systemic immunization. Contrasting   with antigen only-treated mice, there was no induction of interleukin   10-producing antigen-specific CD4(+) cells in BAK-treated animals.   Moreover, the tolerogenic capacity of migrating dendritic cells (DCs)   was reduced, apparently involving differential conditioning by soluble   epithelial factors. Accordingly, epithelial cells exposed in vitro to   BAK were less suppressive and failed to induce tolerogenic DCs in   culture. As this effect of BAK was dependent on epithelial nuclear   factor &#954;B pathway activation, our findings may provide new therapeutic   targets. Thus, tolerance breakdown by BAK should be considered an   important factor in the management of glaucoma and immune-mediated   ocular surface disorders.Mucosal Immunology advance online publication   13 June 2012; doi:10.1038\/mi.2012.44.","palabras_clave":"BENZALKONIUM|TOLERANCE|CONJUNCTIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1585,"idioma_id":4,"titulo":"SULfUR RESISTANCE OF  Pt-W CATALYSTS","resumen":"The sulfur resistance of low-loaded monometallic Pt catalysts and bimetallic Pt-W catalysts during the partial selective hydrogenation of styrene, a model compound of PYGAS streams, was studied.  The effect of metal impregnation sequence on the activity and selectivity was also evaluated.  Catalysts were characterized by ICP, TPR, XRD and XPS techniques.  Catalytic tests with sulfur-free and sulfur-doped feeds were performed.All catalysts showed high selectivities (> 98%) to ethylbenzene.  Activity differences between the catalysts were mainly attributed to electronic effects due to the presence of different electron-rich species of Pt0, and electron-deficient species of Ptä+.  Pt0 promotes the cleavage of H2 while Ptä+ the adsorption of styrene.  The catalyst successively impregnated with W and Pt (WPt\/Al) was more active and sulfur resistant than the catalyst prepared with an inverse impregnation order (PtW\/Al).  The higher poison resistance of WPt\/Al was attributed to the presence of chloride that inhibits the adsorption of thiophene because of steric and electronic effects.  On the other hand, the lower concentration of chloride and a high concentration of Pt0 electron-rich sites (with low BE values) could contribute to the poisoning, as these species would act as electron donor sites, providing available electrons to be bond with the S atom of thiophene.  Both effects would promote a strong adsorption of thiophene and thus an enhanced blocking of the catalyst active sites.","palabras_clave":"bimetallic catalysts |selective hydrogenation |platinum|sulfur resistance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1586,"idioma_id":4,"titulo":"Cobalt-Iron red-ox  behavior in nano-structured La0.4Sr0.6Co0.8Fe0.2O3-d cathodes","resumen":"            Nano-sized La0.4Sr0.6Co0.8Fe0.2O3-d (LSCF) perovskite samples (prepared bya conventional acetate route and a novel acetate synthesis with HMTAadditives), were tested simulating a red-ox cycle. The crystallography wasstudied by X-ray Powder Diffraction (XPD) and the changes in the oxidationstate of the perovskite B-site were evaluated by synchrotron X-ray AbsorptionNear Edge Spectroscopy (XANES). After a reducing treatment, LSFC particles showthe appearance of a new phase that coexists with the original one. Thestructural change is accompanied by a Co and Fe formal oxidation statesdecrease, although Fe remains always closer to 4+ and Co closer to 3+. Thetreatment produces a B-site valence average reduction from 3.52+ to 3.26+ andthe formation of oxygen vacancies. A re-oxidation treatment under O2 richatmosphere at 800ºCfor 10 hours shows that the change is reversible and independent of the twochemical methods used to synthesize the LSCF nano-particles.","palabras_clave":"LSCF cathodes|perovskite|B-site|XANES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1587,"idioma_id":4,"titulo":"Molecular characterization of a phytoplasma of the ash yellows group occurring in strawberry (Fragaria x ananassa Duch.) plants in Argentina","resumen":"        Trabajo aceptado en enero de 2012, publicado online octubre de 2013 y en papel en enero de 2013      Strawberry (Fragaria x ananassa Duch. cv. Camino Real) plants showing phyllody symptoms were detected in production fields in Bella Vista (Corrientes province, Argentina). DNA from all symptomatic samples analyzed yielded fragments of the expected size in PCR reactions using phytoplasma universal primers. DNA from asymptomatic plants yielded no products. The associated phytoplasma was designated as Argentinean Strawberry Phyllody (ASP). The ASP sequence of the 16S rRNA gene showed 99?98% homology with members of the 16SrVII ash yellows group. The putative RFLP profile was indistinguishable fromthe Argentinean alfalfa witches? broom (ArAWB) phytoplasma. The phylogenetic analysis of nearly full-length 16S rDNA sequence and 16S-23S spacer region yielded a consensus tree wherein ASP clustered into the ash yellows group (16Sr VII) with high confidence values (95), generating a separated branch (100 bootstrap value) together with ArAWB (16Sr VII-C). In Argentina, the 16Sr VII group was also detected in alfalfa (Medicago sativa L.) crops, and weeds [Artemisa annua L. and Conyza bonariensis (L.) Cronquist]. To our knowledge, this is the first report of a phytoplasma from the 16Sr VII group affecting strawberries in Argentina and worldwide.","palabras_clave":"Alfalfa|Candidatus Phytoplasma fraxini|Phyllody. RFLP-PCR|Sequence . 16Sr RNA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1589,"idioma_id":4,"titulo":"Anti-ganglioside antibodies induced in chickens by an alum-adsorbed anti-idiotype antibody targeting NeuGcGM3","resumen":"Racotumomab is a murine anti-idiotype cancer vaccine targeting NeuGcGM3 on melanoma, breast and lung cancer. In order to characterize the immunogenicity of alum-adsorbed racotumomab in a non-clinical setting, Leghorn chickens were immunized in dose levels ranging from 25 µg to 1600 µg. Racotumomab was administered subcutaneously in the birds\u2019 neck with three identical boosters and serum samples were collected before, during and after the immunization schedule. A strong antibody response was obtained across the evaluated dose range, confirming the immunogenicity of racotumomab even at dose levels as low as 25 µg. As previously observed when using Freund´s adjuvant, alum-adsorbed racotumomab induced an idiotype-specific response in all the immunized birds and ganglioside-specific antibodies in 60-100% of the animals. In contrast to the rapid induction anti-idiotype response, detection of ganglioside-specific antibodies in responsive animals may require repeated boosting. Kinetics of anti-NeuGcGM3 antibody titers showed a slight decline two weeks after each booster, arguing in favor of repeated immunizations in order to maintain antibody titer.Interestingly, the intensity of the anti-NeuGcGM3 response paralleled that of anti-mucin antibodies and anti-tumor cell antibodies, suggesting that the in vitro detection of anti-ganglioside antibodies might be a surrogate for an in vivo activity of racotumomab. Taken together, these results suggest that Leghorn chicken immunization might become the means to test the biological activity of racotumomab intended for clinical use.","palabras_clave":"NEUGCGM3|RACOTUMOMAB|ANTI-IDIOTYPE ANTIBODY|LEGHORN CHICKENS|ANTOBODY RESPONSES|TUMOR ANTIGENS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1591,"idioma_id":4,"titulo":"Clustering biological data with SOMs: On topology preservation in non-linear dimensional reduction","resumen":"Dimensional reduction is a widely used technique for exploratory   analysis of large volume of data. In biological datasets, each object is   described by a large number of variables (or dimensions) and it is   crucial to perform their analyses in a smaller space, to extract useful   information. Kohonen self-organizing maps (SOMs) have been recently   proposed in systems biology as a useful tool for exploratory analysis,   data integration and discovery of new relationships in *omics datasets.   SOMs have been traditionally used for clustering in several data mining   problems, mainly due to their ability to preserve input data topology   and reduce a high dimensional input space into a 2-D map. In spite of   this, the above-mentioned dimensional reduction can lead to   counterintuitive results. Sometimes, maps having almost the same size,   trained on the same dataset, and with identical learning algorithms and   parameters, may find different clusters. However, one would expect that   small changes in map sizes or another training condition would not   result in an abrupt different location of any of the grouped patterns.   The aim of this work is to analyze and explain this issue through a real   case study involving transcriptomic and metabolomic data, since it   might have an important impact when interpreting clustering results over   a biological dataset.","palabras_clave":"CLUSTERING|BIOINFORMATICS|DIMENSIONAL REDUCTION|TOPOLOGY PRESERVATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1592,"idioma_id":4,"titulo":"Links between perception of parental actions and prosocial behavior in early adolescence","resumen":"We analyzed the links between parental styles,  practices, and empathy and specific forms of prosocial  behaviors in early adolescence. The Argentine scale of  perception of relationships with parents for children and  young adolescents, prosocial tendencies measure, parenting  practices measure, and children´s perception of parental  empathy were administered to a sample of 289 middle class  children, aged 10-16, of both sexes, from primary and  secondary schools in Buenos Aires, Argentina. Correlations  and hierarchical regressions were used to examine  (1) relationships between parental styles, children´s perception  of parental empathy, parental practices, and  children?s prosocial behavior, (2) the amount of unique  prediction from parental styles, children´s perception of  parental empathy, and parental practices to children´s  prosocial behavior. Results indicated that different aspects  of parental actions (parental styles, practice, and empathy)  have a differential relation according to the type of prosocial  behavior involved. When taking these three kinds of  parental behavior into account, parental styles are related to  public and responsive aspects especially through extreme  control by the mother. Parental practices, in turn, are  related mainly with anonymous and altruistic aspects, but  with this latter negatively. Finally, adolescents´ perception  of parental empathy explains added variance in all the  cases, though to a lesser extent.","palabras_clave":"PARENTAL STYLES|PARENTAL PRACTICES |EMPATHY|PROSOCIAL BEHAVIORS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1594,"idioma_id":4,"titulo":"MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells","resumen":"Abstract  Luteinizing hormone (LH) activates ERK1\/2, MAP kinases (MAPK) necessary for its action on steroidogenesis and cell proliferation, and also induces MAPK phosphatase-1 (MKP-1), which rapidly dephosphorylates nuclear ERK1\/2. MKP-3 is a cytoplasmic ERK-phosphatase up-regulated by proliferative stimuli. MKP-3 also dephosphorylates transcription factor FOXO1, promoting its transport to the nucleus. Here we analyzed MKP-3 expression in MA-10 Leydig cells and demonstrated that LH receptor (LHR) activation with human gonadotropin hormone (hCG) and an analog of its second messenger, 8Br-cAMP, up-regulates MKP-3 by transcriptional and post-translational mechanisms. It is known that FOXO1 drives the Expression of the cell cycle inhibitor p21. Since the activation of this transcription factor by MKP-3 has been reported, we assessed the effect of shRNA against MKP-3 on p21mRNA levels. 8Br-cAMP increased these levels (2-fold at 2 h) and MKP-3 down-regulation reduced this effect. Our work demonstrates that LH\/hCG tightly up-regulates MKP-3 which in turn, dephosphorylates ERK1\/2 and drives p21 expression. These events could contribute to counteract hormonal action on cell proliferation.","palabras_clave":"ERK|FOXO|Leydig|MKP-3"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1596,"idioma_id":4,"titulo":"Lethal and sublethal effects of cadmium in the white shrimp Palaemonetes argentinus: A comparison between populations from contaminated and reference sites","resumen":"  In thepresentstudy,theacutetoxicityofcadmium(Cd)inwhiteshrimp(Palaemonetesargentinus) from a metalpollutedlagoon(LosPadres,LP)andfromunpollutedlagoon(NahuelRuca,NR)wasevaluated. Both population,wereexposedto3.06,12.26,30.66,61.32,306and613.2 mg Cd L1 for96-h.The sublethaleffectsofCdwereexaminedbytwocellularbiomarkers:metallothionein(MT)andlipid peroxidation(LPO).Theseasonalvariationsofbiomarkersinbothlagoonswerealsoevaluated. P. argentinus demonstratedahighsensitivitytoCd,withvaluesof96-hLC50lowerandcloseto those ofhighlysensitivespecies;therefore,canbeproposedasagoodindicatorspecies.TheLC50 values of shrimpfromLP(24-h:269.8,48-h:67.45,72-h:30.66,96-h:24.50 mg Cd L1) werehigherthan those fromNR(24-h:153.3,48-h:32.65,72-h:18.40,96-h:12.26 mg Cd L1), indicatingahigher tolerance toCd,anditwasrelatedtotheirorigin.DifferentialresponsesintermsofMTinductionand LPO betweenpopulationswerealsodetected.InNRshrimps,theMTsynthesiswasinducedveryfast (24-h)andevenattheminimumconcentrationtested(3.06 mg Cd L1), whilenoincreaseswere observedinLPOlevels.Incontrast,theMTandLPOlevelsinLPshrimpswerenotincreasedrelativeto control,althoughtheyweremoretoleranttoCdthanthoseofNR;suggestingthepresenceofanother mechanisminvolvedinthedetoxificationofCd.Thedifferencesinbothsensitivityandbiochemical responsestoCdmayberelatedwiththeirenvironmentalhistories. Palaemonetesargentinus) from a metalpollutedlagoon(LosPadres,LP)andfromunpollutedlagoon(NahuelRuca,NR)wasevaluated. Both population,wereexposedto3.06,12.26,30.66,61.32,306and613.2 mg Cd L1 for96-h.The sublethaleffectsofCdwereexaminedbytwocellularbiomarkers:metallothionein(MT)andlipid peroxidation(LPO).Theseasonalvariationsofbiomarkersinbothlagoonswerealsoevaluated. P. argentinus demonstratedahighsensitivitytoCd,withvaluesof96-hLC50lowerandcloseto those ofhighlysensitivespecies;therefore,canbeproposedasagoodindicatorspecies.TheLC50 values of shrimpfromLP(24-h:269.8,48-h:67.45,72-h:30.66,96-h:24.50 mg Cd L1) werehigherthan those fromNR(24-h:153.3,48-h:32.65,72-h:18.40,96-h:12.26 mg Cd L1), indicatingahigher tolerance toCd,anditwasrelatedtotheirorigin.DifferentialresponsesintermsofMTinductionand LPO betweenpopulationswerealsodetected.InNRshrimps,theMTsynthesiswasinducedveryfast (24-h)andevenattheminimumconcentrationtested(3.06 mg Cd L1), whilenoincreaseswere observedinLPOlevels.Incontrast,theMTandLPOlevelsinLPshrimpswerenotincreasedrelativeto control,althoughtheyweremoretoleranttoCdthanthoseofNR;suggestingthepresenceofanother mechanisminvolvedinthedetoxificationofCd.Thedifferencesinbothsensitivityandbiochemical responsestoCdmayberelatedwiththeirenvironmentalhistories. ","palabras_clave":"White shrimp    |Cadmium toxicity|Biomarkers|Environmental history|Cadmium tolerance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1597,"idioma_id":4,"titulo":"The key role of water in the dioxygenase function of Escherichia coli flavohemoglobin","resumen":"Flavohemoglobins (FHbs) are members of the globin superfamily, widely distributed among prokaryotes andeukaryotes that have been shown to carry out nitric oxide dioxygenase (NOD) activity. In prokaryotes, suchas Escherichia coli, NOD activity is a defence mechanism against the NO release by the macrophages of thehosts' immune system during infection. Because of that, FHbs have been studied thoroughly and severaldrugs have been developed in an effort to fight infectious processes. Nevertheless, the protein's structuraldeterminants involved in the NOD activity are still poorly understood. In this context, the aim of the presentwork is to unravel the molecular basis of FHbs structural dynamics-to-function relationship using state of theart computer simulation tools. In an effort to fulfill this goal, we studied three key processes that determineNOD activity, namely i) ligand migration into the active site ii) stabilization of the coordinated oxygen and iii)intra-protein electron transfer (ET). Our results allowed us to determine key factors related to all threeprocesses like the presence of a long hydrophobic tunnel for ligand migration, the presence of a water mediatedhydrogen bond to stabilize the coordinated oxygen and therefore achieve a high affinity, and the bestpossible ET paths between the FAD and the heme, where water molecules play an important role. Takentogether the presented results close an important gap in our understanding of the wide and diverse globinstructural-functional relationships.","palabras_clave":"electron transfer|globin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1599,"idioma_id":5,"titulo":"Cambios de la modalidad decisoria predominante en función de la edad: Su relación con la efectividad de las decisiones tomadas por voluntarios en misiones de paz","resumen":"Es sabido que para el logro de acciones eficaces, en contextos caracterizados por la diversidad cultural y la incertidumbre, se requieren estrategias decisorias que impliquen procesamiento de modalidad intuitiva o analítica, según las circunstancias (Azzollini et al., 2010). El objetivo de este trabajo es determinar experimentalmente si existen diferencias en los modos de procesamiento de la información y la eficacia a la hora de tomar decisiones, en función de la edad de los sujetos. Se evaluó la modalidad de procesamiento decisoria y la efectividad de las decisiones tomadas por 116 soldados voluntarios de distintas edades, en diferentes situaciones en las que se manipuló experimentalmente el grado de incertidumbre cultural. Los resultados indican que los sujetos con mayor edad presentan una clara tendencia hacia el uso de procesos predominantemente intuitivos en la toma de decisiones (F=3.473, p0.052)","palabras_clave":"TOMA DE DECISIONES|EDAD |MODALIDAD DECISORIA|EFECTIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1600,"idioma_id":4,"titulo":"Development patterns of executive functions in children","resumen":"The Executive Functions (EF) realize the behavior and thought control across a set of functionally independent processes like cognitive flexibility (reactive and spontaneous), working memory and planning. The development patterns of these components show different stages of acceleration and deceleration in childhood. In our context there are not registered studies that analyze its development in Spanish-speaking children.  The aim of this work is to analyze the development patterns of EF in order to establish relations and comparisons and to identify for every component the stages of acceleration and stagnation. The sample was comprised of 274 Argentinian schoolchildren aged 6 to 8 years old (119 were from first grade, 61 from second grade and 94 from third grade). The evaluation was realized using the scales of the Battery of Neurological Infantile Evaluation (ENI): Verbal Fluency (Semantic and Phonemic), Cognitive Flexibility, Mexico´s Tower and Digits in regression. There were detected three different patterns from development and different interactions between executive components. In addition three empirical typologies depending on the patterns and the relations between components were established.","palabras_clave":"executive functions|cognitive flexibility|working memory|development patterns"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1602,"idioma_id":4,"titulo":"Effects of land use on environmental conditions and macrophytes in prairie lotic ecosystems","resumen":"Fluvial hydrosystems are environments with large landscape to water surface ratio and therefore particularly vulnerable to changes in land use. We analysed the connection of environmental conditions in 31 prairie streams of the Pampa Plain (Argentina) with regional phytogeography andsurrounding land use. Furthermore, the relationships between riparian conditions, macrophytes andwater physico-chemistry on the reach scale were explored by considering nutrient levels, pH, water conductivity, riparian conditions and the presence of in-stream vegetation cover. Streams draining croplands were characterized by better conservation of the riparian zone, lower pH and higher nitrate than those exposed to cattle intrusion. Unlike surrounding land use, our results revealed that regional phytogeography showed only marginal significant effects on streams. Our results also revealed that a particular combination of environmental variables (poor riparian conditions, high total phosphorous, high pH and low nitrate) was detrimental for the presence of macrophytes. However, the abundance of submersed and emergent macrophytes was not dependent on surrounding land use nor on regional phytogeography.","palabras_clave":"streams |nitrates |cattle|agriculture|argentina|riparian zone"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1603,"idioma_id":4,"titulo":"The use of a Toolkit for health needs assessment on neural tube defects in Argentina","resumen":"Health needs assessment (HNA) is a commonly used process for those working in public health. The PHG Foundation has developed a Toolkit to provide users with a stepwise approach for undertaking a HNA on birth defects. We report the findings from using the Toolkit to examine needs in relation to policies and programs, services, and interventions for neural tube defects (NTDs) in Argentina. The trend over the last few decades is one of decline in infant mortality from nutritional and infectious causes, thus further increasing the relative importance of birth defects. The observed prevalence of NTDs is consistent with that reported internationally. Since 2002 folic acid fortification (FAF) has been mandatory by law, and different studies have shown at least a 50 % decrease in the birth prevalence of NTDs after FAF. In Argentina, there is inequity between the public and non-public health sectors. The birth prevalence of NTDs seems lower in the non-public sector, possibly as a result of better nutritional status of women, higher access to folic acid supplementation, and earlier prenatal diagnosis followed by termination of pregnancy (ToP) in non-public hospitals. Although illegal, ToP is believed to be widespread, with better access for people of higher socioeconomic status. Through the process of HNA, we identified several unmet needs regarding registration of cases, public and professional education, legislation, and organization of care pathways. In our experience, the Toolkit brought together people working on the same issue, and it engaged and motivated experts and stakeholders to work together to tackle the problem.","palabras_clave":"NEURAL TUBE|HEATH SERVICES|MALFORMATIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1604,"idioma_id":4,"titulo":"Enhanced nestin expression and small blood vessels in human pituitary adenomas","resumen":"The role of angiogenesis in human pituitary tumor progression is questioned. Our aim was to characterize the morphologic changes that occur in the vasculature of pituitary adenomas, in correlation with the expression of&nbsp; nestin, a protein found in endothelial cells of newly formed&nbsp;vessels of developing organs. We also evaluated the relation of angiogenic markers and nestin with Ki-67 index. Immunohistochemical studies were performed on paraffin&nbsp; embedded samples of 47 pituitary adenomas and six normal&nbsp; pituitaries. We determined microvessel density (number of&nbsp;CD31? or CD34? vessels per square millimetre), vascular&nbsp; area (cumulative area occupied by vessels), average vessel&nbsp; size, and further classified vessels as small (@ lm2) or&nbsp; large ([100 lm2). We correlated the above parameters with&nbsp; nestin expression and Ki-67 index. Lower vascular areacompared to normal tissue was found in adenomas&nbsp; (p.05). Interestingly, pituitary adenomas had signifi cantly more small vessels than control pituitaries (p.04 for CD31 and CD34). In tumors many capillaries were positive for nestin, while scarce staining was detected in controls, so that nestin positive area was significantly higher in tumors. Furthermore, nestin area correlated positively with the % of small vessels. Ki-67 correlated neither with vascular area nor with nestin expression. In human pituitary tumors there was a predominance of small capillaries in correlation with increased expression of the progenitor marker nestin. We suggest that angiogenesis is an active 36process in these tumors, in spite of their low total vascular area when compared to normal pituitaries","palabras_clave":"TUMORIGENESIS |ANGIOGENESIS|PROLIFERATION|NESTIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1605,"idioma_id":4,"titulo":"The social cost of dredging: The Bahia Blanca estuary case","resumen":"The Bahia Blanca Estuary System constitutes an ecosystem unique in the world by its physical, geographic and biological characteristics. In the frame of a major investment project related with natural gas provision, a dredging process has been planned and its execution results imminent. However, the analysis of socioeconomic effects of this dredging process has not been performed up to now. In this context, our objective is to  estimate social costs and benefits of the dredging process related with the gas plant project mainly derived from the loss of the nursery services of the estuary and the loss of the jobs associated with fishing activities. Our results indicate that socioeconomic cost of the dredging related with the project is between US$ 5 million and US$ 6.5 million depending on how the displaced labor force can be reallocated.","palabras_clave":"Ecosystem services|Dredging|Bahia Blanca Estuary"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1607,"idioma_id":5,"titulo":"Analisis de Preconceptos referidos a fenómenos eléctricos en alumnos ingresantes de la FACEyN","resumen":"La experiencia docente muestra que los alumnos que realizan el curso introductorio del estudio de la electricidad en las carreras de la FACEN presentan ciertas dificultades para la interpretación de algunas cuestiones referidas a electrostática y corriente eléctrica. Las causas de estas dificultades son variadas pero sostenemos que la más importante se debe a que el alumno presenta preconceptos erróneos no resueltos debidamente en niveles educativos anteriores. Para detectar estos preconceptos de los estudiantes hemos realizado un relevamiento en alumnos ingresantes a la FACEN, cohorte 2011, mediante el análisis de las respuestas brindadas a un cuestionario que consta de diez preguntas de interpretación cualitativa referidas a situaciones básicas de la teoría eléctrica. Luego del análisis y valoración de los resultados, surgieron diversas cuestiones a considerar; entre ellas destacamos, la confirmación de la existencia, en los alumnos que conformaron la muestra, de preconcepciones erróneas referidas a los fenómenos eléctricos y la necesidad de implementar estrategias de enseñanza y aprendizaje enfocadas en la solución de este problema.","palabras_clave":"Preconceptos|Enseñanza de la Física|Fenómenos Eléctricos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1608,"idioma_id":4,"titulo":"Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina","resumen":"Due to the current epidemiological situation of pertussis, several countries have implemented  vaccination strategies that include a booster dose for adolescents. Since there is still no evidence  showing that the adolescent booster has a positive effect on the most vulnerable group  represented by infants, it is difficult to universalize the recommendation to include such  reinforcement. In this work we present an age-structured compartmental deterministic model that  considers the outstanding epidemiological features of the disease in order to assess the impact of  the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different  parameterizations of the model that represent distinct possible epidemiological scenarios. The  results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces  the incidence of the disease within this age group, but has a very low impact on the risk group  (0?1 year). An effort to improve the coverage of the first dose would have a much greater impact  on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness  of these conclusions.","palabras_clave":"MODELOS|MATEMATICOS|PERTUSSIS|INFECCIOSAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1610,"idioma_id":4,"titulo":"Maintenance and thermal stabilization of NADH dehydrogenase-2 conformation upon elimination of its C-terminal region","resumen":"Development of an artificial enzyme with activity and structure comparable to that of natural enzymes is an important goal in biological chemistry. Respiratory NADH dehydrogenase-2 (NDH-2) of  Escherichia coli is a peripheral membrane-bound flavoprotein, belonging to a group with scarce structural information. By eliminating the C-terminal region of NDH-2, a water soluble version with significant enzymatic activity was previously obtained. Here, NDH-2 structural features were established, in comparison to those of the truncated version. Far-UV circular dichroism, Fourier transform infrared spectroscopy and limited proteolysis analysis   showed that the overall structure of both proteins was similar at 30°C. Experimental data agree with the predicted NDH-2 structure (PDB: 1OZK). The absence of C-terminal region stabilized in ~5?10°C the truncated Protein conformation. However, truncation impaired enzymatic activity at low temperatures, probably due to the weak interaction of the mutant protein with FAD cofactor.","palabras_clave":"NDH-2|FAD|Truncated protein|Secondary structure|Protein thermal stability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1611,"idioma_id":4,"titulo":"Global pressures, specific responses: effects of nutrient  enrichment in streams  from different biomes","resumen":"Abstract We assessed the effects of nutrient enrichment on three stream ecosystems running through distinct biomes (Mediterranean, Pampean and Andean). We increased concentrations of N and P in stream water 1.6 to 4-fold following a Before-After Control-Impact Paired Series (BACIPS) design in each 31 stream, and evaluated changes in the biomass of bacteria, primary producers, invertebrates, and fish 32 in the enriched (E) versus control (C) reaches after nutrient addition through a predictive BACIPS 33 approach. The treatment produced variable biomass responses (2-77 % of explained variance) 34 among biological communities and streams. The greatest biomass response was observed for algae 35 in the Andean stream (77 % of the variance), although fish also showed important biomass 36 responses (ca. 9-48 %). The strongest biomass response to enrichment (77 % in all biological 37 compartments) was found in the Andean stream. The magnitude and seasonality of biomass 38 responses to enrichment were highly site-specific, often depending on the basal nutrient 39 concentration and on windows of ecological opportunity (periods when environmental constraints 40 other than nutrients do not limit biomass growth). The Pampean stream, with high basal nutrient 41 concentrations, showed a weak response to enrichment (except for invertebrates), whereas the 42 greater responses of Andean stream communities were presumably favored by wider windows of 43 ecological opportunity in comparison to those from the Mediterranean stream. Despite variation 44 among sites, enrichment globally stimulated the algal-based food webs (algae and invertebrate 45 grazers) but not the detritus-based food webs (bacteria and invertebrate shredders). The present 46 study shows that nutrient enrichment tends to globally enhance the biomass of stream biological 47 assemblages, but that its magnitude and extent within the food web is complex and strongly 48 determined by environmental factors and ecosystem structure.","palabras_clave":"BIOMES|NUTRIENT ENRICHMENT|STREAM ECOSYSTEM|WINDOWS OF OPORTUNITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1612,"idioma_id":4,"titulo":"'BIOLOGICAL TRAITS AND GROWTH PATTERNS OF PEJERREY ODONTESTHES ARGENTINENSIS'","resumen":"This study assesses for the first time the relationship between annual cycles of different Biological indices with growth patterns of a marine pejerrey Odontesthes argentinensis population near its southern-distribution boundary in north Patagonia. The reproductive period is between September and November evidenced by an increase of the gonado-somatic index with a peak in October corresponding to spawning. The reproductive cycle was also coupled with metabolism processes related to energy allocation as shown by changes in the hepatosomatic index and body condition. Total length (LT) at maturity was 270 and 282 mm for females and males whereas fecundity was estimated at mean ± S.D. = 9380 ± 1797 mature oocytes. Based on marginal increment analysis, most of the scales showed a maximum value during the summer, with a sharp decline thereafter during the autumn and winter, indicating that scale rings are formed during the latter period and only once a year. Growth fitted by the von Bertalanffy model for both males and females did not show significant differences and showed a rapid growth during the first 2 years. The shorter reproductive period compared with the northern O. argentinensis populations inhabiting tropical and subtropical areas was interpreted as an adjustment to temperate environmental conditions. The larger maximum LT and LT at first maturity are in agreement with the counter gradient hypothesis and could be related to the selective effects of low temperature and a shorter growing season. This latitude dependency argues strongly against the application of the same fishing regulations for different O. argentinensis populations as a whole and reinforces the need to assess basic biological features at a population scale to promote local sustainable fisheries management.","palabras_clave":"BIOLOGICAL INDICES|LATITUDINAL EFFECTS|NORTH PATAGONIA|REPRODUCTIVE AND GROWTH PATTERNS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1613,"idioma_id":4,"titulo":"Down-regulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces up-regulation of PTEN.","resumen":"Hsp27 (HSPB1) is usually overexpressed in breast cancers affecting the disease outcome and the sensitivity of tumors to chemotherapy and radiotherapy. Hsp27 interacts with other proteins such as &#946;-catenin, histone deacetylase HDAC6, transcription factor STAT2 and procaspase-3. Phosphatase and tensin homologue (PTEN) is a tumor suppressor gene that is deleted in many human tumors. The PI3K\/Akt signaling pathway is negatively regulated by PTEN. Hsp27 is described as a key component of the Akt signaling cascade: Akt, BAD, Forkhead transcription factors, Hsp27, mitogen-activated protein kinase kinase-3 and -6. Here, we have examined whether the downregulation of Hsp27 by siHsp27 affects the PTEN levels in the MCF-7 human breast cancer cell line. PTEN was detected with two different antibodies using western blots and immunocytochemistry. p-Akt was also evaluated by western blot. In addition, Hsp27 and PTEN were immunoprecipitated to know whether these proteins interact. Intracellular colocalization studies were carried out by confocal microscopy. A significant reduction in the Hsp27 levels was noted in the siHsp27 transfected cells. These Hsp27 downregulated cells showed a significant increased expression of PTEN. The MW 76 and 55 kDa PTEN forms were upregulated as revealed by two different antibodies. The phosphatase activity of PTEN seems to be active because p-Akt levels were reduced. Hsp27 immunoprecipitation was bringing PTEN and vice versa, these two proteins seem to interact at cytoplasmic level by FRET. Downregulation of Hsp27 stabilized PTEN protein levels. Chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) levels were not significantly influenced by Hsp27 downregulation. In conclusion, we report a novel function of Hsp27 modulating the PTEN levels in human breast cancer cells suggesting an interaction between these two molecules.","palabras_clave":"Hsp27|HDAC6|PTEN|human breast cancer cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1614,"idioma_id":4,"titulo":"Prevalence of Canine Juvenile Generalized Demodicosis in Buenos Aires region, Argentina","resumen":"Juvenile Generalized Demodicosis is a common condition in dogs, associated with genetic and immunological factors.  It is not contagious or zoonotic disease, however, is a serious and potentially dangerous to the animal´s life.  Affects most of the races while noting that there are some more predisposition. This paper analyzed 499 records of the Small Animal Hospital (Faculty of Veterinarian Sciences, National University of La Plata, Argentina) for the period 1998-2006. In all cases of dogs tested were considered primarily to those who had some type of dermatology disease, and of these, those who were eventually diagnosed as Demodectic mange. Twenty-eight out of 499 exhibited Juvenile Generalized Demodicosis. Coincident with the data reported by other research, this study evidenced that certain breeds, such as German Shepherd, Boxer and Mixed breed dogs had higher prevalence. These results would support the hypothesis that Juvenile Generalized Demodicosis have a greater predisposition in certain breeds.","palabras_clave":"BREED|CANINE|DEMODICOSIS|MANGE|PREVALENCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1615,"idioma_id":5,"titulo":"Actividades de Cálculo Diferencial con Computadora: Estudio de Habilidades Matemáticas Desarrolladas","resumen":"El presente artículo reporta un estudio transeccional descriptivo sobre el desarrollo de habilidades matemáticas así como la relación de éstas con actividades matemáticas y contenidos específicos. Analizamos producciones escritas de estudiantes de carreras de ingeniería que realizan su primer curso de Cálculo Diferencial. Para esta experiencia han trabajado en un taller usando el software Mathematica®. Describimos los criterios considerados para la clasificación de las actividades y habilidades, los instrumentos para la evaluación y el procesamiento de los datos. En las conclusiones establecemos relaciones entre tipos de actividades y habilidades promovidas y nos referimos al rol del software en la enseñanza y en el aprendizaje de la introducción al Cálculo Diferencial. Finalmente mediante el análisis estadístico descriptivo y el de componentes principales reforzamos la hipótesis de que una habilidad debe medirse en estrecha dependencia con el contenido y la tarea realizada.","palabras_clave":"Habilidades|Diseño|Software|Cálculo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1619,"idioma_id":4,"titulo":"Measurement of the flavour composition of dijet events in pp collisions at s&#8730;=7 TeV with the ATLAS detector","resumen":"This paper describes ameasurement of the flavourc&#8730;omposition of dijet events produced in pp collisions ats = 7 TeV using the ATLAS detector. The measurementuses the full 2010 data sample, corresponding to an integratedluminosity of 39 pb&#8722;1. Six possible combinations oflight, charm and bottom jets are identified in the dijet events,where the jet flavour is defined by the presence of bottom,charm or solely light flavour hadrons in the jet. Kinematicvariables, based on the properties of displaced decay verticesand optimised for jet flavour identification, are used ina multidimensional template fit to measure the fractions ofthese dijet flavour states as functions of the leading jet transversemomentum in the range 40 GeV to 500 GeV and jetrapidity |y| < 2.1. The fit results agree with the predictionsof leading- and next-to-leading-order calculations, with theexception of the dijet fraction composed of bottom and lightflavour jets, which is underestimated by all models at largetransverse jet momenta. The ability to identify jets containingtwo b-hadrons, originating from e.g. gluon splitting, isdemonstrated. The difference between bottom jet productionrates in leading and subleading jets is consistent withthe next-to-leading-order predictions.","palabras_clave":"ATLAS|JET|FLAVOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1620,"idioma_id":4,"titulo":"Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance","resumen":"BACKGROUND AND AIMS:     Specific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR.         METHODS AND RESULTS:     780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ¡Ý 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p&nbsp;=&nbsp;0.005) and abdominal obesity (p&nbsp;=&nbsp;0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p&nbsp;=&nbsp;0.001) and waist circumference (p&nbsp;=&nbsp;0.001). rs8074124CC- carriers showed lower fasting insulin (p&nbsp;=&nbsp;0.017) and HOMA-IR (p&nbsp;=&nbsp;0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p&nbsp;=&nbsp;0.009) and hypertriglyceridemic waist (p&nbsp;=&nbsp;0.006). rs12051836CC- carriers showed lower fasting insulin (p&nbsp;=&nbsp;0.043) and HOMA-IR (p&nbsp;=&nbsp;0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p&nbsp;=&nbsp;0.026) and HDL-C (p&nbsp;=&nbsp;0.014) as a continuous variable.         CONCLUSIONS:     We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.       ","palabras_clave":"SOCS7|INSULIN RESISTANCE|TAGSNPs|INFLAMMATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1622,"idioma_id":4,"titulo":"Linking Ecosystem Resistance, Resilience And Stability In Steppes Of North Patagonian","resumen":"The main objective of an ecosystem sustainable management is to preserve its capacity to respond and adapt to current disturbances and\/or future changes, and maintain the provision of environmental goods and services. Two very important properties linked to this objective are the ecosystem resilience and resistance to disturbance factors. The Structural?Functional State and Transition Model (SFSTM) is a conceptual framework that allows evaluating the ecosystem resilience and resistance based on structural and functional attributes. On the other hand, the Landscape Functional Analysis (LFA) presents a method to assess the rangeland ?health? based on structural vegetation and soil indicators, creating indexes to evaluate the ecosystem functional integrity. The aim of this study is to integrate LFA and SFSTM as an approach to help validate indicators and indexes associated with the resistance, resilience, and stability of a temperate rangeland ecosystem. States and transitions model for a shrubby-grasses steppe of the Western Patagonian District was used as a reference system. Changes in vegetation structure, soil surface, and loss of soil due to erosion were determined in sites with different grazing histories. Based on the SFSTM, we assessed the relationships between ecosystem structural changes with the recruitment process of the plant community and ecosystem integrity indexes (sensu LFA). Our results indicate that the decrease in the recruitment process, related to different grazing histories, was associated with a loss of ecosystem functional integrity. This was associated to a decrease in the ability to retain, store, and use rain water, and also in nutrient cycling. This suggests that the integration of the LFA methodology to the SFSTM can be used for indexes validation, which in turn allows the identification of critical thresholds associated with ecosystem resilience loss. Finally, throughout the integration of indicators of LFA into SFSTM, we established relationships between ecosystem resistance, resilience, and stability in response to a disturbance factor (e.g. overgrazing). Thus, we used this information to define states in stable, unstable, mixed-unstable, and indifferent-stable dynamic equilibriums. Our proposed approach provides a tool for ecosystem assessment regarding the identification of states that can be restored and those that might be more susceptible to degradation. Such information might help in the prevention of crossing a critical threshold and be used for sustainable management programs in rangelands.","palabras_clave":"EQUILIBRIUM|INTEGRITY INDEX|STATE AND TRANSITION|STRUCTURAL-FUNCTIONAL|THRESHOLD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1623,"idioma_id":4,"titulo":"The atf2 gene is involved in triacylglycerol biosynthesis and accumulation in the oleaginous Rhodococcus opacus PD630","resumen":"Abstract Rhodococcus opacus PD630 is an oleaginous bacteriumable to accumulate large amounts of triacylglycerols(TAG) in different carbon sources. The last reaction for TAGbiosynthesis is catalyzed by the bifunctional wax ester synthase\/acyl-CoA:diacylglycerol acyltransferase (WS\/DGAT)enzymes encoded by atf genes. R. opacus PD630 possessesat least 17 putative atf homologous genes in its genome, butonly atf1 and atf2 exhibited a significant DGAT activity whenexpressed in E. coli, as revealed in a previous study. Thecontribution of atf1 gene to TAG accumulation by strainPD630 has been demonstrated previously, although additionalAtfs may also contribute to lipid accumulation, since the atf1-disrupted mutant is still able to produce significant amounts ofTAG (Alvarez et al., Microbiology 154:2327?2335, 2008). Inthis study, we investigated the in vivo role of atf2 gene inTAGaccumulation by R. opacus PD630 by using different geneticstrategies. The atf2-disrupted mutant exhibited a decrease inTAG accumulation (up to 25?30 %, w\/w) and an approximatelytenfold increase in glycogen formation in comparisonwith the wild-type strain. Surprisingly, in contrast to singlemutants, a double mutant generated by the disruption of atf1and atf2 genes only showed a very low effect in TAG and inglycogen accumulation under lipid storage conditions. Overexpressionof atf1 and atf2 genes in strain PD630 promoted anincrease of approximately 10 % (w\/w) in TAG accumulation,while heterologous expression of atf2 gene in Mycobacteriumsmegmatis caused an increase in TAG accumulation duringcultivation in nitrogen-rich media. This study demonstratedthat, in addition to atf1 gene, atf2 is actively involved in TAGaccumulation by the oleaginous R. opacus PD630.","palabras_clave":"Triacilgliceridos|Rhodococcus|DGAT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1624,"idioma_id":4,"titulo":"Concentration of arsenic in water, sediments and fish species from naturally contaminated rivers","resumen":"Arsenic (As) may occur in surface freshwater ecosystems as a consequence of both natural contamination and anthropogenic activities. In this paper, As concentrations in muscle samples of 10 fish species, sediments and surface water from three naturally contaminated rivers in a central region of Argentina are reported. The study area is one of the largest regions in the world with highAs concentrations in groundwater. However, information of As in freshwater ecosystems and associated biota is scarce. An extensive spatial variability of As concentrations in  water and sediments of sampled ecosystems was observed. Geochemical indices indicated that sediments ranged from mostly unpolluted to strongly polluted. The concentration of As in sediments averaged 6.58 lg\/g ranging from 0.23 to 59.53 lg\/g. Arsenic in sediments barely followed (r = 0.361; p = 0.118) the level of contamination of water. All  rivers showed high concentrations of As in surface waters, ranging from 55 to 195 lg\/L. The average concentration of As in fish was 1.76 lg\/g. The level of contamination with As differed significantly between  species. Moreover, the level of bioaccumulation of As in fish species related to the concentration ofAs in water and sediments also differed between species. Whilst some fish species seemed to be able to regulate the uptake of this metalloid, the concentration of As in the large catfish Rhamdia quelen mostly followed the concentration of As in abiotic compartments. The erratic pattern of As concentrations in fish and  sediments regardless of the invariable high levels in surface waters suggests the existence of complex biogeochemical processes behind the distribution patterns of As in these naturally contaminated ecosystems.","palabras_clave":"arsenic|freshwater biota|biomonitoring|rivers|argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1625,"idioma_id":4,"titulo":"Heat treatment of peach fruit: modifications in the extracellular compartment and identification of novel extracellular proteins","resumen":"Ripening of peach (Prunus persica L. Batsch) fruit is accompanied by dramatic cell wall changes that lead to softening. Post-harvest heat treatment is effective in delaying softening and preventing some chilling injury symptoms that this fruit exhibits after storage at low temperatures. In the present work, the levels of twelve transcripts encoding proteins involved in cell wall metabolism, as well as the differential extracellular proteome, were examined after a post-harvest heat treatment (HT; 39 °C for 3 days) of ?Dixiland? peach fruit. A typical softening behaviour, in correlation with an increase in 1-aminocyclopropane-1-carboxylic acid oxidase-1 (PpACO1), was observed for peach maintained at 20 °C for 3 days (R3). Six transcripts encoding proteins involved in cell wall metabolism significantly increased in R3 with respect to peach at harvest, while six showed no modification or even decreased. In contrast, after HT, fruit maintained their firmness, exhibiting low PpACO1 level and significant lower levels of the twelve cell wall-modifying genes than in R3. Differential proteomic analysis of apoplastic proteins during softening and after HT revealed a significant decrease of DUF642 proteins after HT; as well as an increase of glyceraldehyde-3-phosphate dehydrogenase (GAPC) after softening. The presence of GAPC in the peach extracellular matrix was further confirmed by in situ immunolocalization and transient expression in tomato fruit. Though further studies are required to establish the function of DUF642 and GAPC in the apoplast, this study contributes to a deeper understanding of the events during peach softening and after HT with a focus on this key compartment.","palabras_clave":"CELL WALL|PEACH|TREATMENT|POST HARVEST"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1626,"idioma_id":4,"titulo":"Plastidial NADP-Malic Enzymes from grasses: unravelling the way to the C4 specific isoforms","resumen":"Malic enzyme is present in many plant cell compartments such as plastids, cytosol and mitochondria.  Particularly relevant is the plastidial isoform that participates in the C4cycle providing CO2to RuBisCO in  C4 species. This type of photosynthesis is more frequent among grasses where anatomical preconditioning would have facilitated the evolution of the C4syndrome. In maize (C4grass), the photosynthetic NADP dependent Malic enzyme (ZmC4-NADP-ME,L-malate:NADP oxidoreductase, E.C. 1.1.1.40)  and the closest related non-photosynthetic isoform (ZmnonC4-NADP-ME,L-malate:NADP oxidoreductase,  E.C. 1.1.1.40) are both plastidial but differ in expression pattern, kinetics and structure. Features like high  catalytic efficiency, inhibition by high malate concentration at pH 7.0, redox modulation and tetramerization are characteristic of the photosynthetic NADP-ME. In this work, the proteins encoded by  sorghum (C4grass) and rice (C3grass) NADP-ME genes, orthologues of the plastidial NADP-MEs from  maize, were recombinantly expressed, purified and characterized. In a global comparison, we could  identify a small group of residues which may explain the special features of C4enzymes. Overall, the  present work presents biochemical and molecular data that helps to elucidate the changes that took  place in the evolution of C4NADP-ME in grasses.  2012 Elsevier Masson SAS. All rights reserved  C4photosynthesis  NADP-malic enzyme  Maize  Sorghum  Rice  Structureefunction relationship","palabras_clave":"NADP MALIC ENZYME|MAIZE|SORGHUM|RICE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1627,"idioma_id":4,"titulo":"Functional characterization of residues involved In redox-modulation of maize photosynthetic NADP-malic enzyme activity","resumen":"Two highly similar plastidic NADP-malic enzymes (NADP-ME) are found in the C4 species maize (Zea mays); one exclusively expressed in the Bundle Sheath Cells (BSC) and involved in C4 photosynthesis (ZmC4-NADP-ME); and the other (ZmnonC4-NADP-ME) with housekeeping roles. In the present work, these two NADP-MEs were analyzed regarding their redox-dependent activity modulation. The results clearly show that ZmC4-NADP-ME is the only one modulated by the redox status, and that its oxidation produces a conformational change that limits the catalytic process, although inducing higher-affinity binding of the substrates. The reversal of ZmC4-NADP-ME oxidation by chemical reductants suggests the presence of thiol groups able to form disulphide bonds. In order to identify the Cys residues involved in the activity modulation, site-directed mutagenesis and MALDI-TOF analysis of ZmC4-NADP-ME were performed. The results obtained allowed the identification of Cys192, Cys246 (not conserved in ZmnonC4-NADP-ME), Cys270 and Cys410 as directly or indirectly implicated in ZmC4-NADP-ME redox-modulation. These residues may be involved in forming disulphide bridge\/s or in the modulation of the oxidation of the critical residues. Overall, the results indicate that, apart from having gained high level of expression and localization in BSC, ZmC4-NADP-ME displays a particular redox-modulation, which may be required to accomplish the C4 photosynthetic metabolism. Therefore, the presented work could provide new insights into the regulatory mechanisms that might have been involved for recruiting genes for the C4-pathway during evolution.","palabras_clave":"C4 photosynthesis|NADP-malic enzyme|redox-modulation|structure-function"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1628,"idioma_id":5,"titulo":"Hábito y calidad del desayuno en alumnos de dos escuelas primarias públicas de la ciudad de Santa Fe","resumen":"El desayuno proporciona la energía y los nutrientes necesarios que permiten un óptimo rendimiento físico e intelectual.           Objetivo: Conocer la frecuencia del desayuno, los factores que condicionan el hábito y su omisión,la calidad del desayuno y la colación en los niños de escuelas públicas de la ciudad de Santa Fe.           Población y métodos: Estudio descriptivo ransversal. Se evaluaron 637 alumnos mediante una encuesta estructurada de respuestas           cerradas.          Resultados: El 75% de los niños desayunaban diariamente; solo 1,6% realizaban un desayuno de buena calidad. Consumir el desayuno todos los días o a veces no dependía de la compañía de un familiar. De 1°a 5° grado la frecuencia semanal dependió de que algún familiar lo preparara (valor p=0,04). La causa principal de omisión del desayuno fue la falta de tiempo. El 23% de           los alumnos de 6°-7° grado manifestaron sentir malestar al desayunar. Más del 50% de los niños miraban televisión mientras desayunaban. La mayoría de los niños de 1ro a 3er grado consumieron un desayuno de mejorable (41%) e insuficiente calidad (41%). En los alumnos de 4° y 5° grado predominó el de insuficiente calidad (50%). En el grupo de 6° y 7° grado fue notable           el consumo de desayuno de mala calidad (16%). En muy pocos niños la colación resultó apropiada para completar la calidad final del desayuno.          Conclusiones: Si bien se encontró un alto porcentaje de escolares que tienen el hábito de desayunar, la mayoría lo hacen de forma           incompleta. Muy pocos logran completar la calidad del desayuno con los alimentos ingerido.","palabras_clave":"FRECUENCIA DE DESAYUNO|CALIDAD DEL DESAYUNO|COLACIÓN|ESCOLARES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1629,"idioma_id":4,"titulo":"A novel method to produce a hierarchical porous carbon as a conductive support of PtRu particles. Effect on CO and Methanol electrooxidation","resumen":"The fabrication and catalytic properties of hierarchical porous carbon loaded with PtRu particles was  studied. A silica nanoparticles opal is filled with resorcinol\/formaldehyde resin, which is then pyrolized  to form a macroporous carbon. Depending on synthesis conditions the volume contraction induces  mesopore formation in the macroporous carbon, creating a hierarchical porous carbon (HPC). The  material consists of a thick, highly porous electrocatalytic film. PtRu nanoparticles were loaded inside the  HPC by reduction of metallic ions with formic acid. The electrocatalytic activity toward CO and methanol  oxidation was evaluated. The current densities for methanol electrooxidation at 60 C (220 mA cm2 and  120 Ag1 at 0.55 VRHE) reveals high activity, suggesting that the catalysts consist of well disperse, small  PtRu nanoparticles, with a low degree of agglomeration and good accessibility for reactants.","palabras_clave":"Hierarchical porous carbon|Methanol electrooxidation|PtRu catalyst|CO stripping"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1630,"idioma_id":4,"titulo":". Evaluation of concentration efficiency of the Pseudomonas aeruginosa phage PP7 in various water matrixes by different methods","resumen":"Enteric viruses monitoring in surface waters requires the concentration of viruses before detection assays. The aim of this study was to evaluate different methods in terms of recovery efficiencies of bacteriophage PP7 of Pseudomonas aeruginosa, measured by real-time PCR, using it as a viral control process in water analysis.   Different nucleic acid extraction methods (silica-guanidiniumthiocyanate, a commercial kit (Qiagen Viral RNA kit) and phenol-chloroform with alcohol precipitation) exhibited very low recovery efficiencies (0.08 to 4.18 %), being the most efficient the commercial kit used for subsequent experiments. To evaluate the efficiency of three concentration methods, PBS (as model for clean water) as well as water samples from rivers were seeded to reach high (HC, 106 pfu\/mL) and low concentration (LC, 104 pfu\/mL) of PP7. Tangential ultrafiltration proved to be more efficient (50.36+\/-12.91, 17.21+\/-9.22, and 12.58+\/-2.35 % for HC in PBS and two river samples, respectively) than adsorption-elution with negatively charged membranes (1.00+\/-1.34, 2.79+\/-2.62, and 0.05+\/-0.08 % for HC in PBS and two river samples, respectively) and polyethyleneglycol precipitation (15.95+\/-7.43, 4.01+\/-1.12, and 3.91+\/-0.54 %, for HC in PBS and two river samples, respectively), being 3.2-50.4 times more efficient than the others for PBS and 2.7-252 times for river samples. Efficiencies also depended on the initial virus concentration and aqueous matrixes composition.   In consequence, the incorporation of an internal standard like PP7 along the process is useful as a control of the water concentration procedure, the nucleic acid extraction, the presence of inhibitors, the variability of the recovery among replicas, and for the calculation of the sample limit of detection. Thus, the use of a process control, as presented here, is crucial for the accurate quantification of the viral contamination.","palabras_clave":"Virus concentration|Surface water|PP7|Absorption\/elution"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1632,"idioma_id":4,"titulo":"Root architecture of Arabidopsis is affected by competition with neighbouring plants","resumen":"How roots detect and respond to the presenceof neighbors is relevant to understand plant belowgroundinteractions. The aim of the present work was to evaluatethe effect of the presence of neighboring plants and thelimited availability of phosphorus on root architecture. Atarget plant of Arabidopsis thaliana (Ler or Col) was surroundedby combinations of two individuals (Ler and Col),and subjected to different growth conditions (levels ofactivated charcoal (AC) and phosphorus). Both accessionsconsistently concentrated their roots towards the competitionzone shared with a neighbor of the same accession,avoiding the side shared with the other accession. All thesecompetition strategies disappeared when plants were limitedby phosphorus or when activated charcoal was addedto the growth media. Plants produced consistently fewerbut longer lateral roots when activated charcoal was addedto the growth media irrespective of the neighbors. Ourresults indicate a direct role of secondary metabolitespresent in the root exudates and phosphorus availability inthe response of presence and identity of neighboring roots","palabras_clave":"Arabidopsis thaliana|Root architecture|Root competition|Root exudates"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1633,"idioma_id":4,"titulo":"On the perfect MgH2(-Nb,-Zr) systems and the influence of vacancy-like defects on their structural properties. A self-consistent first principle calculations study of the electron and positron parameters","resumen":"The electronic and structural properties of MgH2 systems containing vacancies and Zr or Nb as dopants were studied using self-consistent calculations. The density of states were computed using the Vienna Ab initio Simulation Package (VASP) and the orbital overlap population weighted DOS with the Amsterdam Density Functional program. The metal-metal and metal-hydrogen bonds in the perfect hydride and this material containing a neutral Mg or H vacancies or a neutral mixed Mg-H vacancy complex were analyzed. The same calculations were also performed in the magnesium hydride with a Nb or a Zr atom as a substitutional impurity and on these systems containing the above mentioned vacancies. Simultaneously, the influence of vacancies in the hydride was studied through the calculation of the positron lifetimes and the positron-electron momentum distributions in the previously referred materials. Secondly, information on the influence of vacancies on the electron momentum density of the MgH2(-Nb,-Zr) systems was additionally obtained through the calculation of the positron-electron momentum distributions. The results obtained indicate that in the pure hydride the presence of vacancies and impurities notable diminishes the force in the atomic bonds. The stability decrease of the bonds was correlated with changes in the positron wave function in the same sites of the structures. Moreover, it was found that these changes in the positron wave function are in good agreement with the decrease of the positron lifetimes.","palabras_clave":"MgH2|vacancy|positron|hydrogen"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1634,"idioma_id":4,"titulo":"Transcriptional elongation and alternative splicing","resumen":"Alternative splicing has emerged as a key contributor to proteome   diversity, highlighting the importance of understanding its regulation.   In recent years it became apparent that splicing is predominantly   cotranscriptional, allowing for crosstalk between these two nuclear   processes. We discuss some of the links between transcription and   splicing, with special emphasis on the role played by transcription   elongation in the regulation of alternative splicing events and in   particular the kinetic model of alternative splicing regulation. This   article is part of a Special Issue entitled: RNA polymerase II   Transcript Elongation.","palabras_clave":"Transcriptional elongation|Alternative Splicing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1635,"idioma_id":4,"titulo":"Differential expression of distinct soybean resistance genes interacting with Argentinean isolates of Diaporthe phaseolorum var. meridionalis","resumen":"Soybean Stem Canker (SSC), caused by Diaporthe phaseolorum var. meridionalis (Dpm), is an important disease of soybean in Argentina. There are five known dominant genes that confer resistance to SSC, Rdm1 to Rdm5. Particularly, Rdm2 was identified in cv. Tracy-M and then it was stabilized in the breeding line T2. The Rdm4 gene was first identified in cv. Hutcheson. More recently it was found that this gene was linked to the Rdm5 gene, defining the Rdm4-5 resistance region in Hutcheson. The objective of this work was to analyze the behaviour of the dominant Rdm2, Rdm4 and Rdm5 genes interacting with the CE109 and CE112 local physiological races of Dpm, in different susceptible backgrounds (genotypes RA702 and J77-339). Rdm4 and Rdm5 segregated phenotypically as completely dominant genes in the specific interactions with the CE109 and CE112 isolates, respectively, in both susceptible backgrounds. Similarly, Rdm2 segregated as expected for a complete dominant gene in the specific interaction with the CE109 isolate, in both susceptible backgrounds. However, when interacting with the CE112 isolate, the Rdm2 gene did not segregate as expected for a completely dominant gene, neither in RA702 nor in J77-339 susceptible background. The distorted segregation of the Rdm2 gene was due to incomplete penetrance. To the best of our knowledge this is the first report documenting changes in the degree of penetrance of a soybean resistance gene (Rdm2) depending upon the physiological race of Dpm which interacts with and the genetic background in which the Rdm gene is being expressed.","palabras_clave":"Glycine max|Incomplete penetrance|Rdm resistance genes|Soybean Stem Canker"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1637,"idioma_id":4,"titulo":"Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings","resumen":"Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson´s disease - EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test - KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle\/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.","palabras_clave":"ACE|PARKINSON_DESEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1639,"idioma_id":4,"titulo":"Platinum-nickel catalyst: The effect of promoters in cis-oleic acid adsorption","resumen":"The study of the cis-oleic acid adsorption, on clean and promoted (K, Mg, Co, B or Pd) PtNi(1 1 1) surface was performed by quatum chemical calculations. The oleic acid adsorption on PtNi(1 1 1) surface shows a weak molecule?surface interaction. No preferential site for C=C adsorption is computed and only the C=O adsorption is favored on the clean PtNi(1 1 1) surface. The adsorption properties of the PtNi(1 1 1) are improved by promoters. The stability of the system is increased and the C=C\/surface distances are reduced when promoters are present. Among the considered promoters, Co has the best performance in terms of system stability. The lowest C p orbital substantially interacts with Pt and Co s, p and d orbitals.  The change electron density of metal centers, enhance the C=C adsorption being the Pt?C interaction the more favored. After adsorption, the strength of the C=C, Pt-Pt and   Pt-Co bonds decrease while a molecule?surface bond is formed.","palabras_clave":"Platinum-nickel |adsorption|cic-oleic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1642,"idioma_id":4,"titulo":"COMPARISON OF THE EFFECTIVENESS  > BETWEEN MICROSATELLITES AND SNP PANELS FOR GENETIC IDENTIFICATION,  > TRACEABILITY AND PARENTAGE IN AN INBRED ANGUS HERD","resumen":"During the last decade, microsatellites  (STRs, Short Tandem Repeats)   have been successfully used in animal genetic  identification, such as   traceability and paternity. In the last years single  nucleotide   polymorphisms (SNPs) have increased popularity. An efficient SNP    identification system requires a marker set with enough power to   identify  individuals and their parents. Usually, genetic diagnostics   include the  analysis of related animals. In this work, the degree of   information obtained  through SNPs versus STRs within a consanguineous   herd was compared. Thirty-six  closely related Angus were genotyped for   18 STRs and 116 SNPs. Cumulative SNPs  exclusion power (Q) values for   paternity and sample matching (MP) resulted  higher than 0.9998 and   4.32E. Between 2 and 3 SNPs per STR were  needed to obtain an equivalent   Q value. MP showed that 24 SNPs are equivalent  to the 12 STRs ISAG   (International Society for Animal Genetics) minimal  recommended set.   These results could provide real valuable  genetic data that support the   consensus SNP panel for bovine genetic  identification developed by the   Parentage Recording Working Group of ICAR  (International Committee for   Animal Recording).            ","palabras_clave":"MICROSATELLITE|SINGLE NUCLEOTIDE POLYMORPHISM|EXCLUSION PROBABILITY|GENETIC IDENTIFICATION|BOVINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1644,"idioma_id":4,"titulo":"Phenotypic differentiation of ecologically significant Brachidontes species co-occurring in intertidal mussel beds from the Southwestern Atlantic","resumen":"Intertidal communities from rocky shores of the southwestern Atlantic are dominated by two small-sized mussels of the genus Brachidontes, B. rodriguezii (d?Orbigny, 1846) and B. purpuratus (Lamarck, 1819). Their generic placement, separation of specimens based on external conchological characters and geographic distribution are problematic. We conducted a comparative study based on extensive collections and observations at 14 sites along the coasts of the southwestern Atlantic, complemented by the study of materials from museum collections. Well-preserved specimens of the two species are distinguishable on the basis of shell characters, some of them previously ignored, over their combined latitudinal range.","palabras_clave":"Brachidontes|Mytilids|Western Atlantic|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1645,"idioma_id":4,"titulo":"DETERMINATION OF CHEMICAL OXYGEN DEMAND EMPLOYED MANGANESE AS AN ENVIRONMENTALLY FRIENDLY OXIDIZING REAGENT BY A FLOW INJECTION METHOD BASED ON MICROWAVE DIGESTION AND SPECIATION COUPLED TO ICP-OES","resumen":"A novel flow injection (FI) system for chemical oxygen demand (COD) determination is evaluated. Manganese (VII) is used as oxidant. FI microwave solid phase extraction system by activated carbon (AC) was employed. FI system involves a digestion circuit, placed in a home MW oven, coupled to inductively coupled plasma-optical emission spectrometry. Manganese (II) was determined after the reduction of Mn (VII) and eluted from AC with nitric acid (1 % v\/v) at pH 4. Doehlert experimental design has been used to speed up the optimization of assisted digestion methods and the optimum values obtained for different  experimental variables studied. The method can give a high throughput of about 22 samples per 60 min. Under optimum conditions, the evaluated assisted digestion methods have been successfully applied to several pure organic compounds and real samples. A large linear range of 2.6-850 mg O2 L-1 with an excellent detection limit of 1.25 mg O2 L-1was obtained  with a correlation coefficient of 0.998. The interference by high chloride concentration was studied, and values below 3000 mg Cl- ions L-1, is not interfering in the estimation of COD load without any masking agents. COD values for various types of wastewater samples were well correlated with those obtained by standard manual methods. Thus, the FI-MWSPE method seems to be an interesting and promising alternative to conventional COD digestion methods since it is faster and reduces reagent volume, hazardous emission and external contamination with a good reproducibility and accuracy.","palabras_clave":"CHEMICAL OXYGEN DEMAND|MANGANESE|ON-LINE MICROWAVE DIGESTION|SOLID PHASE EXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1646,"idioma_id":5,"titulo":"Ecological photodynamic therapy: New trend to disrupt the intricate networks within tumor ecosystem","resumen":"As with natural ecosystems, species within the tumor microenvironment are connected by pairwise interactions  (e.g.mutualism, predation) leading to a strong interdependence of different populations on each other. In this reviewwe  have identified the ecological roles played by each non-neoplastic population (macrophages, endothelial  cells, fibroblasts) and other abiotic components (oxygen, extracellular matrix) directly involved with neoplastic  development. A way to alter an ecosystem is to affect other species within the environment that are supporting  the growth and survival of the species of interest, here the tumor cells; thus, some features of ecological systems  could be exploited for cancer therapy.We propose awell-known antitumor therapy called photodynamic therapy  (PDT) as a novelmodulator of ecological interactions.We refer to this as ?ecological photodynamic therapy.? The  main goal of this new strategy is the improvement of therapeutic efficiency through the disruption of ecological  networkswith the aimof destroying the tumor ecosystem. It is therefore necessary to identify those interactions  from which tumor cells get benefit and those by which it is impaired, and then design multitargeted combined  photodynamic regimes in order to orchestrate non-neoplastic populations against their neoplastic counterpart.  Thus, conceiving the tumor as an ecological systemopens avenues for novel approaches on treatment strategies.","palabras_clave":"Photodynamic |Hypoxia|Angiogenesis|Stroma"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1647,"idioma_id":4,"titulo":"Identification of the principal patterns of summer moisture transport in South America and their representation by WCRP\/CMIP3 global climate models","resumen":"The goal of this study is to assess the ability of a set of global climate models (GCMs) to represent the main regional spatial patterns of austral summer moisture transport in South America in order to evaluate if one of the possible causes of GCMs misestimating summer precipitation in this region could be associated with an erroneous representation of these patterns. For this purpose, NCEP\/NCAR reanalysis and 20 GCMs from the WCRP\/CMIP3 Multimodel Dataset for the period 1960-1999 were considered. Extreme cases of moisture transport patterns were selected to assess their association with rainfall anomalies. Results obtained indicate that only some aspects of water vapor transport and convergence in South America as well as the associated precipitation anomalies can be reproduced adequately by GCMs. Finally, a case study is presented showing that one of the moisture transport patterns identified was observed during December 2008- February 2009.","palabras_clave":"climate change|global climate models|moisture transport|rainfall"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1648,"idioma_id":4,"titulo":"Relationship between 129I and 127I contents in bovine thyroid glands from Argentina","resumen":"129I\/127I ratios and iodine concentrations in   bovine thyroids stemming from Argentina were determined by accelerator   mass spectrometry (AMS) and gas chromatography (GC), respectively. From   these measurements, a relationship of the 129I\/127I ratio with iodine content in the gland was obtained. A weak correlation between the two isotopes was found, suggesting that 129I re-emission from the ocean is not the only process for the 129I deposition in Argentina. Moreover, contributions to the total 129I   inventory in the Southern hemisphere from both natural and   anthropogenic sources were theoretically studied. Surface compartments   present similar contribution from natural sources and nuclear explosions   fallout.","palabras_clave":"129I|ACCELERATOR MASS SPECTROMETRY|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1650,"idioma_id":4,"titulo":"Molecular identification of the secondary endosymbiont Hamiltonella defensa in the rose-grain aphid Metopolophium dirhodum","resumen":"This is the first report of the association between the rose-grain aphid  Metopolophium dirhodum, a potentially important cereal pest and the facultative symbiont Hamiltonella defensa. the infection with this gamma-proteobacterium was determined by PCR in laboratory-reared and feld-collected specimens of an Argentinian population of the aphid. Partial bacterial 16S, IGS and 23S rRNA genes were sequenced and compared to other available Hamiltonella sequences by phylogenetic analysis. the present study provides new information on previously unknown M. dirhodum microbiota.","palabras_clave":"APHIDIDAE|FACULTATIVE SYMBIONT|GAMMA-PROTEOBACTERIA|PCR|SEQUENCING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1651,"idioma_id":4,"titulo":"A histopathological survey of the razor clam Ensis macha (Pharidae) along the Patagonian coast","resumen":"This is the first study performed to determine the health status of the razor clam, Ensis macha, including six different populations along Argentina Patagonian coast and one of Chile. The parasites and pathologies affecting E. macha were analyzed and their prevalence and mean intensity values were calculated. To establish which factors affect the presence and intensity of infection, Generalized Linear Models (GLMs) were applied. Basophilic inclusions, ciliates, coccidians protozoans, and turbellarians were found. We report an Aporocotylidae digenean and hemocyte infiltrations. None of the parasites is OIE (World Organisation for Animal Health) notifiable, and none seemed to be pathogenic, with the exception of the digenean. The prevalence of the parasites was affected mainly by environmental factors (such as site of sampling and season), instead of intrinsic conditions of the clam (such as size, index condition, sex and gonadal stage). The maximum intensity of parasites was registered during temperate or cold seasons, corresponding with the poorest condition index and with the partially spawned gonadal stage of E. macha. During this stage, the clams would need to store energy for the next gametogenesis cycle, being more susceptible to the infection by the parasites.","palabras_clave":"ENSIS MACHA|HEALTH STATUS|PATAGONIAN COAST|PATHOLOGIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1652,"idioma_id":4,"titulo":"Isolation of Pseudobutyrivibrio ruminis and Pseudobutyrivibrio xylanivorans from rumen of Creole goats fed native forage diet","resumen":"We isolated and identified functional groups of bacteria in the rumen of Creole goats involved in ruminal fermentation of native forage shrubs. The functional bacterial groups were evaluated by comparing the total viable, total anaerobic, cellulolytic, hemicellulolytic, and amylolytic bacterial counts in the samples taken from fistulated goats fed native forage diet (Atriplex lampa and Prosopis flexuosa). Alfalfa hay and corn were used as control diet. The roll tubes method increased the possibility of isolating and 16S rDNA gene sequencing allowed definitive identification of bacterial species involved in the ruminal fermentation. The starch and fiber contents of the diets influenced the number of total anaerobic bacteria and fibrolytic and amylolytic functional groups. Pseudobutyrivibrio ruminis and Pseudobutyrivibrio xylanivorans were the main species isolated and identified. The identification of bacterial strains involved in the rumen fermentation helps to explain the ability of these animals to digest fiber plant cell wall contained in native forage species.","palabras_clave":"PSEUDOBUTYRIVIBRIO RUMINIS|PSEUDOBUTYRIVIBRIO XYLANIVORANS|CREOLE GOATS|FORAGE DIET"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1653,"idioma_id":4,"titulo":"A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease","resumen":"Galectins, a family of glycan-binding proteins, influence tumor progression by modulatinginteractions between tumor, endothelial, stromal and immune cells. Despite considerable progress In identifying the roles of individual galectins in tumor biology, an integrated portrait of the galectin network in different tumor microenvironments is still missing. We undertook this study to analyze the ´galectin signature´ of the human prostate cancer (PCa) microenvironment with the overarching goal of selecting novel molecular targets for prognostic and therapeutic purposes. In examining androgen-responsive and castration-resistant PCa cells and primary tumors representing different stages of the disease, we found that galectin-1 (Gal-1) was the most abundantly expressed galectin in PCa tissue and was markedly upregulated during disease progression. In contrast, all other galectins were expressed at lower levels: Gal-3, -4, -9 and -12 were downregulated during disease evolution, while expression of Gal-8 was unchanged. Given the prominent regulation of Gal-1 during PCa progression and its predominant localization at the tumor-vascular interface, we analyzed the potential role of this endogenous lectin in PC angiogenesis. In human PCa tissue arrays, Gal-1 expression correlated with the presence of blood vessels, particularly in advanced stages of the disease. Silencing Gal-1 in PCa cells reduced tumor vascularization without altering expression of other angiogenesis-related genes. Collectively, our findings identify a dynamically regulated ´galectin-specific signature\u2019 that accompanies disease evolution in PCa, and they highlight a major role for Gal-1 as a tractable target for anti-angiogenic therapy in advanced stages of the disease.","palabras_clave":"Prostate Cancer|Galectins"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1654,"idioma_id":5,"titulo":"Análisis comparativo de desechos de talla en contextos del Pleistoceno Final\/Holoceno temprano de Chile y Argentina","resumen":"Se presenta el análisis comparativo de conjuntos de desechos de talla lítica provenientes de sitios tempranos de la región pampeana argentina y de la Patagonia chilena asociados a puntas de proyectil tipo Fell 1 o cola de pescado. El objetivo es avanzar en la discusión sobre las formas de organizarse y sobre la vinculación entre prácticas sociales y lugares en el pasado. Para ello se aplica la metodología de análisis nodular mínimo (Larson & Kornfeld 1997) y el análisis no tipológico que se basa en modelos de extracción de lascas (Ingbar 1989). Los resultados se discuten en relación a aquéllos ya obtenidos aplicando otra metodología en el caso pampeano y se los consideran una exploración útil del caso patagónico. En la visión comparativa de los resultados resalta la discontinuidad de las trayectorias en todos los conjuntos, ya que prácticamente sólo un segmento de la secuencia de manufactura está representado en cada sitio. También resalta la semejanza en las curvas obtenidas para Cueva Fell, Cerro El Sombrero Abrigo 1 y Cima. Se plantea que, las actividades de talla sobre distintas materias primas desarrolladas en cada sitio parecen estar en gran medida ligadas a las prácticas vinculadas a ese espacio en sí, y no sólo a la trayectoria esperable de la roca en relación a su calidad, disponibilidad y proveniencia. Finalmente, resulta interesante que esta modalidad sea compartida en regiones tan distantes como Pampa y el extremo sur de Patagonia por gente que también compartió los conocimientos necesarios para fabricar instrumentos como colas de pescado y piedras discoidales. Por ello, a partir de este trabajo proponemos que además de los conocimientos prácticos de cómo realizar una tarea posiblemente se estuvieran compartiendo también otras cuestiones más relacionadas a la esfera de los vínculos entre la gente y su entorno, o sea, aquellas que conciernen a la compleja trama de decisiones que implica la (1989). Los resultados se discuten en relación a aquéllos ya obtenidos aplicando otra metodología en el caso pampeano y se los consideran una exploración útil del caso patagónico. En la visión comparativa de los resultados resalta la discontinuidad de las trayectorias en todos los conjuntos, ya que prácticamente sólo un segmento de la secuencia de manufactura está representado en cada sitio. También resalta la semejanza en las curvas obtenidas para Cueva Fell, Cerro El Sombrero Abrigo 1 y Cima. Se plantea que, las actividades de talla sobre distintas materias primas desarrolladas en cada sitio parecen estar en gran medida ligadas a las prácticas vinculadas a ese espacio en sí, y no sólo a la trayectoria esperable de la roca en relación a su calidad, disponibilidad y proveniencia. Finalmente, resulta interesante que esta modalidad sea compartida en regiones tan distantes como Pampa y el extremo sur de Patagonia por gente que también compartió los conocimientos necesarios para fabricar instrumentos como colas de pescado y piedras discoidales. Por ello, a partir de este trabajo proponemos que además de los conocimientos prácticos de cómo realizar una tarea posiblemente se estuvieran compartiendo también otras cuestiones más relacionadas a la esfera de los vínculos entre la gente y su entorno, o sea, aquellas que conciernen a la compleja trama de decisiones que implica la tecnología entendida en su sentido amplio.","palabras_clave":"DESECHOS LITICOS|POBLAMIENTO TEMPRANO|TECNOLOGÏA|CONO SUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1655,"idioma_id":4,"titulo":"Genetic analysis of the 3' untranslated region of the bovine SLC11A1 gene reveals novel polymorphisms.","resumen":"Polymorphisms in microsatellites at the 30 untranslated region (30UTR) of the SLC11A1 (solute carrier family 11 member A1) gene have been associated with natural resistance to Brucella abortus and Mycobacterium bovis infection in livestock species. Here, we carried out an individual genetic analysis of the two microsatellites present at the 30UTR SLC11A1 gene in 254 Bos taurus purebred, 125 B. indicus purebred and 54 B. taurus 9 B. indicus crossbred cattle. The genotyping by capillary electrophoresis showed the presence of four alleles (157, 159, 161 and 163) for the first microsatellite (MS1) and six alleles (175, 177, 179, 181, 183 and 185) for the second microsatellite (MS2). The alleles 159 and 175 were the most frequent in all breeds analyzed. B. taurus showed the most homogeneous haplotype and genotype for both microsatellites, whereas B. indicus showed the most heterogeneous haplotype and genotype. Two novel variants (alleles 161 and 163) within the MS1 are reported as well as novel variants in MS2 in Holstein breed. The knowledge of the polymorphisms distribution in both microsatellites at the 30UTR of the SLC11A1 gene in cattle breeds is useful for future experimental design to evaluate the association between reported genotypes and natural resistance to pathogens infection0 untranslated region (30UTR) of the SLC11A1 (solute carrier family 11 member A1) gene have been associated with natural resistance to Brucella abortus and Mycobacterium bovis infection in livestock species. Here, we carried out an individual genetic analysis of the two microsatellites present at the 30UTR SLC11A1 gene in 254 Bos taurus purebred, 125 B. indicus purebred and 54 B. taurus 9 B. indicus crossbred cattle. The genotyping by capillary electrophoresis showed the presence of four alleles (157, 159, 161 and 163) for the first microsatellite (MS1) and six alleles (175, 177, 179, 181, 183 and 185) for the second microsatellite (MS2). The alleles 159 and 175 were the most frequent in all breeds analyzed. B. taurus showed the most homogeneous haplotype and genotype for both microsatellites, whereas B. indicus showed the most heterogeneous haplotype and genotype. Two novel variants (alleles 161 and 163) within the MS1 are reported as well as novel variants in MS2 in Holstein breed. The knowledge of the polymorphisms distribution in both microsatellites at the 30UTR of the SLC11A1 gene in cattle breeds is useful for future experimental design to evaluate the association between reported genotypes and natural resistance to pathogens infection","palabras_clave":"SLC11A1 gene|Cattle|NRAMP1 gene"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1657,"idioma_id":4,"titulo":"Differences in population parameters of Rattus norvegicus in urban and rural habitats of central Argentina","resumen":"Life history characteristics are influenced by both biotic and abiotic factors of the environment. The aim of this study was to compare life history strategies of Rattus norvegicus populations of urban and rural habitats in central-east Argentina. Live trapping of rodents was conducted along one year in a shanty town and along two years in poultry farms. Abundance did not differ between habitats.Age structure was similar in both habitats but varied among seasons. Rats in poultry  farms had better body condition, attained sexual maturity at a lower age, produced larger litters and had a higher reproductive  potential than rats from  the shanty town. These differences may be due to differences in habitat favourability or in selection pressures between the two habitats. Our results  show that rats may adopt different life history strategies according to habitat conditions.","palabras_clave":"LIFE HISTORY|RATS|REPRODUCTION|URBAN|RURAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1658,"idioma_id":4,"titulo":"The Functional and Phylogenetic Implications of the Myology of the Lumbar Region, Tail, and Hind Limbs of the Lesser Grison (Galictis cuja)","resumen":"Mustelids are a morphofunctionally diversified group. However, there are no descriptions of the postcranial musculature of South American mustelid species except for some comments from the 19th century. Here, we present the first description of the myology of the hind limbs, and lumbar, sacral, and caudal regions of the lesser grison (Galictis cuja), a short-legged South American mustelid, including muscle maps and weight data. We interpret the function and the evolution of several muscular features within a comparative framework and through the optimization of these traits onto a phylogeny. The configuration of the axial musculature (e.g., m. quadratus lumborum with short bundles, heavy iliocostalis, and forward originated sacrocaudalis dorsalis) and the presence of strong ankle musculature are features shared with mustelines and, to a lesser degree, with other musteloids. These could be related to a high mobility of the axial skeleton and strong control of the movement of the ankle joint, in relation to the acquisition of epigean bounding gaits, a crouched locomotion, and enhanced maneuverability inside burrows. We recorded many phylogenetically significant traits, shared with other arctoids (e.g., subdivision of m. gluteus profundus and semimembranosus, presence of a single belly for m. sartorius, and absence of articularis coxae) or exclusively musteloids (e.g., frequent fusion between m. piriformis and gluteus medius). Some features (e.g., restricted origin of the caudal belly of the m. semitendinosus, absence of gluteofemoralis, and unusually complex fibularis brevis) seem to be derived conditions acquired in some mustelid clades. Our results sustain the value of myological data for functional and phylogenetic studies.","palabras_clave":"Galictis|Hind limb|Lumbar region|Mustelidae|Myology|Tail"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1659,"idioma_id":4,"titulo":"n\u0002Decane Dehydrogenation on Bimetallic PtSn and PtGe Catalysts Prepared by Dip\u0002Coating","resumen":"The production of olefins is very important in the petrochemicaland petroleum refining industries due to theirapplication in several processes. One of the main sourcesof olefins is the thermal cracking of the petroleum crude(mainly for ethylene and propylene production) and, morerecently, through catalytic processes. Taking into accountthe important demand of olefins, mainly those used forthe production of polymers and fuel additives, and the highcost of thermal cracking equipment, there is an increasinginterest in the development of new catalytic technologiesto obtain high yield to olefins.","palabras_clave":"DIP COATING|CATALIZADORES BIMETALICOS|DESHIDROGENACION DE N- DECANO|CARACTERIZACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1660,"idioma_id":4,"titulo":"SIMULTANEOUS DETERMINATION OF ACESULFAME-K AND ASPARTAME USING LINEAR SWEEP VOLTAMMETRY AND MULTIVARIATE CALIBRATION","resumen":"A simple and rapid method to determine acesulfame-K and aspartame simultaneously in power sweeteners,  without pretreatment was proposed. This method employs linear sweep voltammetry assisted with multi-  variate calibration tools, in order to resolve the overlapping signals of both analytes. Multivariate calibration  models were made using a Partial Last Square (PLS) algorithm. In order to increase sensitivity a rotating disk  electrode (RDE) at 8000 rpm was used. The sample throughput was 90 samples h  &#8722;  1  . The obtained results are  in good agreement with that obtained with HPLC method. This paper proposed an alternative methodology  for improving the quality control of power sweeteners.","palabras_clave":"ASESULFAME|ASPARTAME|VOLTAMMETRY|MULTIVARIATE CALIBRACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1661,"idioma_id":4,"titulo":"Development of an electroanalytical method for the determination of lead in Argentina raw propolis based on bismuth electrodes","resumen":"Propolis is a honeybee product which contains lead as one of the main contaminants. Taking into account that this product is used in the food industry, the Código Alimentario Argentino establishes maximum allowable level for raw propolis. Therefore, in this study an electroanalytical method to determine this metal in Argentina raw propolis samples was developed. A bismuth film electrode plated on a modified glassy carbon electrode was prepared. The use of these electrodes has been proposed as an alternative to mercury film electrodes in electroanalytical chemistry due to low toxicity of bismuth (environmentally friendly metal). The method presents a linear range between 1 - 50 µg L&#8722;1 of Pb(II). The limits of detection and quantification were 0.6 µg L&#8722;1 and 1.84 µg L&#8722;1, respectively. The reproducibility and repeatability calculated as the relative standard deviations were 7.4% and 7.0%, respectively. The sample throughput was 21 sample h&#8722;1. Argentina raw propolis samples were analyzed and some of them showed high levels of lead. The obtained results with this method are in good agreement with that obtained with the ICP-AES technique. Moreover, it is good a alternative to the quality control of raw propolis.","palabras_clave":"PROPÓLEOS|PLOMO|VOLTAMPEROMETRIA|ELECTRODOS DE BISMUTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1662,"idioma_id":4,"titulo":"Phosphate Mediated Adsorption and Electron Transfer of Cytochrome C. A Time-Resolved SERR Spectroelectrochemical Study","resumen":"The study of proteins immobilized on biomimetic or biocompatible electrodes represents an active field of research as it pursues both fundamental and technological interests. In this context, adsorption and  redox properties of cytochrome c (Cyt) on different electrode surfaces have been extensively reported,10 although in some cases with contradictory results. Here we report a SERR spectroelectrochemical study  of the adsorption and electron transfer behaviour of the basic protein Cyt on electrodes coated with amino-terminated monolayers. The obtained results show that inorganic phosphate (Pi) and ATP anions are able to mediate high affinity binding of the protein with preservation of the native structure and rendering an average orientation that guaranties efficient pathways for direct electron transfer. These 15 findings aid to the design of Cyt-based bioelectronic devices and to understanding the modulation by Pi and ATP of physiological functions of Cyt.","palabras_clave":"Adenosine Triphosphate|Cytochromes c|Electron Transport"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1664,"idioma_id":4,"titulo":"Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment","resumen":"Photodynamic therapy (PDT) is a novel cancer treatment. It involves the activation of a photosensitizer (PS) with light of specific wavelength, which interacts with molecular oxygen to generate singlet oxygen and other reactive oxygen species (ROS) that lead to tumor cell death. When a tumor is treated with PDT, in addition to affect cancer cells, the extracellular matrix and the other cellular components of the microenvironment are altered and finally this had effects on the tumor cells survival. Furthermore, the heterogeneity in the availability of nutrients and oxygen in the different regions of a tridimensional tumor has a strong impact on the sensitivity of cells to PDT. In this review, we summarize how PDT affects indirectly to the tumor cells, by the alterations on the extracellular matrix, the cell adhesion and the effects over the immune response. Also, we describe direct PDT effects on cancer cells, considering the intratumoral role that autophagy mediated by hypoxia-inducible factor 1 (HIF-1) has on the efficiency of the treatment.","palabras_clave":"Photodynamic therapy|Cancer|Extracellular matrix|Cell adhesion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1665,"idioma_id":4,"titulo":"Call centres employment practices in global value networks: A view from Argentina as a receiving economy","resumen":"The growth of offshored services has brought about an important flux of jobs from developed towards developing countries. In this context, outsourced call centres, with their complex insertion of services across countries and organisations, demonstrate a high potential to create jobs, thus influencing the labour markets of a particular country. However, there are some doubts about the quality, longevity and working conditions that these jobs afford. This article uses the conceptual background of global value chains and global networks in order to analyse the impact of outsourcing and offshoring call centre activities on the employment practices, organisation, management and quality of jobs in the receiving economy of Argentina.","palabras_clave":"call centers|labour relations|Argentina|Outsourced call centers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1667,"idioma_id":4,"titulo":"Different levels of leptin regulate different target enzymes involved in progesterone synthesis.","resumen":"OBJECTIVE: To study the effects of different doses of leptin on the expression of proteins involved in P synthesis, such as steroidogenic acute regulatory protein (StAR), cytochrome P450 side chain cleavage (P450scc), and 3beta-hydroxysteroid dehydrogenase (3betaHSD).  DESIGN: Experimental studies.  SETTING: Research laboratory.  ANIMAL(S): Immature rats primed with gonadotropins to induce ovulation.  INTERVENTION(S): In vivo studies: rats received either an acute or daily  treatment with leptin. In vitro studies: ovarian explants were cultured in the absence or presence of leptin (0.3-500 ng\/mL).  MAIN OUTCOME MEASURE(S): The expression of both messenger RNA and protein of StAR, P450scc, and 3betaHSD were measured by reverse transcription-polymerase chain reaction (PCR) and Western blot, respectively.  RESULT(S): The acute treatment with leptin, which inhibits the ovulatory process,caused a significant reduction in the ovarian expression of P450scc withoutchanges in StAR or 3betaHSD. In contrast, the daily treatment, which induces the ovulatory process, showed an increased expression of the ovarian 3betaHSD protein,without differences in the other proteins measured. We also found that leptin increased the protein of both P450scc and 3betaHSD at physiological levels and inhibited both messenger RNA and protein of 3&#946;HSD at higher concentrations.  CONCLUSION(S): The results indicate that 1) leptin is able to regulate the expression of the 3betaHSD protein in a dose-dependent manner; and 2) leptin seems to exert its dual effects on P synthesis on different targets in a dose-dependent manner.","palabras_clave":"LEPTIN|StAR|P450scc|3BETA-HSD|OVARY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1669,"idioma_id":5,"titulo":"Argentina en la Feria del Libro de Frankfurt. Notas sobre Política Cultural","resumen":"En 2010 Argentina fue invitada de honor y país-tema en la Feria del Libro de Frankfurt que, actualmente, es la más importante del mundo y es donde los intercambios internacionales definen los materiales, los autores y los formatos que serán editados, traducidos y comercializados en los ámbitos nacionales. Reparticiones del Estado nacional y de la Ciudad Autónoma de Buenos Aires, editores, cámaras empresariales, asociaciones y actores individuales, se involucraron activamente en la construcción y en las definiciones de la presentación en este espacio. La importancia del evento, sumado a que Argentina fue elegido por primera vez como paístema, potenciaron la dimensión simbólica de la participación en la feria poniendo en tensión distintas significaciones. El objetivo de este artículo es describir y analizar desde la perspectiva de políticas culturales algunas disputas en torno a identidad y cultura relacionadas con los preparativos para la presentación de Argentina en Frankfurt a partir de sus repercusiones en los medios gráficos.","palabras_clave":"Argentina|Feria del Libro de Frankfurt|Políticas Culturales|Identidades"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1670,"idioma_id":4,"titulo":"New Palaeogene cingulates (Mammalia, Xenarthra) from Santa Rosa, Perú and their importance in the context of South American faunas","resumen":"The record of Palaeogene cingulate xenarthrans in low latitudes is very poor. The cingulate fauna from the Yur´ua River nearSanta Rosa in eastern Per´u is important because it is one of the oldest known from the Palaeogene of Per´u and because ofits tropical latitudinal position. Although remains are scarce, we recognize three new taxa: two species of Astegotheriini(Dasypodidae); Parastegosimpsonia peruana gen. et sp. nov., of small size, related to Eocene species from Patagonia; andanother newspecies, ?Parastegosimpsonia sp. nov.,which consists of an incomplete osteodermrepresenting the largest speciesof this tribe. A third species, Yuruatherium tropicalis gen. et sp. nov., of indeterminate suprageneric rank, shares featureswith Machlydotherium Ameghino (Casamayoran-Tinguirirican SALMA ? middle Eocene-early Oligocene of Patagonia) andis similar to Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Parastegosimpsonia peruana gen. et sp. nov., of small size, related to Eocene species from Patagonia; andanother newspecies, ?Parastegosimpsonia sp. nov.,which consists of an incomplete osteodermrepresenting the largest speciesof this tribe. A third species, Yuruatherium tropicalis gen. et sp. nov., of indeterminate suprageneric rank, shares featureswith Machlydotherium Ameghino (Casamayoran-Tinguirirican SALMA ? middle Eocene-early Oligocene of Patagonia) andis similar to Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Parastegosimpsonia sp. nov.,which consists of an incomplete osteodermrepresenting the largest speciesof this tribe. A third species, Yuruatherium tropicalis gen. et sp. nov., of indeterminate suprageneric rank, shares featureswith Machlydotherium Ameghino (Casamayoran-Tinguirirican SALMA ? middle Eocene-early Oligocene of Patagonia) andis similar to Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Yuruatherium tropicalis gen. et sp. nov., of indeterminate suprageneric rank, shares featureswith Machlydotherium Ameghino (Casamayoran-Tinguirirican SALMA ? middle Eocene-early Oligocene of Patagonia) andis similar to Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Machlydotherium Ameghino (Casamayoran-Tinguirirican SALMA ? middle Eocene-early Oligocene of Patagonia) andis similar to Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Eocoleophorus Oliveira et al. (Deseadan SALMA ? late Oligocene of Brazil). We assign ?Machlydotheriumintortum Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.Ameghino (from the late Eocene of Patagonia) to Yuruatherium. Sediments bearing these cingulates also yieldedrodents, marsupials and notoungulates, among the most frequent mammals. The absolute age of the sediments is unknownbut an estimated age is inferred from studies of the mammalian assemblages. The age of the Santa Rosa local fauna isstill controversial and given the groups taken into account, could be from Early Eocene to Late Oligocene. According tosequences of southern cingulate faunas (especially those of Dasypodidae), the cingulates from Santa Rosa also suggest anage between the Late Eocene and Early Oligocene. Nevertheless, the very low latitude of the Santa Rosa local fauna shouldbe taken into account because in lower latitudes it is not uncommon to find taxa with a more generalized set of charactersthan those present in contemporary taxa from higher latitudes.","palabras_clave":"Cingulata|Palaeogene|Astegotheriini|Perú"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1671,"idioma_id":4,"titulo":"Rapid and efficient localization of depth electrodes and cortical labeling using free and open source medical software in epilepsy surgery candidates","resumen":"Depth intracranial electrodes (IEs) placement is one of the most used procedures to identify the epileptogenic zone (EZ) in surgical treatment of drug resistant epilepsy patients, about 20?30% of this population. IEs localization is therefore a critical issue defining the EZ and its relation with eloquent functional areas. That information is then used to target the resective surgery and has great potential to affect outcome. We designed a methodological procedure intended to avoid the need for highly specialized medical resources and reduce time to identify the anatomical location of IEs, during the first instances of intracranial EEG recordings. This workflow is based on established open source software; 3D Slicer and Freesurfer that uses MRI and Post-implant CT fusion for the localization of IEs and its relation with automatic labeled surrounding cortex. To test this hypothesis we assessed the time elapsed between the surgical implantation process and the final anatomical localization of IEs by means of our proposed method compared against traditional visual analysis of raw post-implant imaging in two groups of patients. All IEs were identified in the first 24 H (6?24 H) of implantation using our method in 4 patients of the first group. For the control group; all IEs were identified by experts with an overall time range of 36 h to 3 days using traditional visual analysis. It included (7 patients), 3 patients implanted with IEs and the same 4 patients from the first group. Time to localization was restrained in this group by the specialized personnel and the image quality available. To validate our method; we trained two inexperienced operators to assess the position of IEs contacts on four patients (5 IEs) using the proposed method. We quantified the discrepancies between operators and we also assessed the efficiency of our method to define the EZ comparing the findings against the results of traditional analysis.","palabras_clave":"epilepsy|electrodes|seeg|MRI|localization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1673,"idioma_id":4,"titulo":"Formal music education not only enhances musical skills, but also conceptions of teaching and learning: a study with woodwind students","resumen":"This paper studies conceptions of woodwind students regarding learning and teaching music, within the framework of implicit theories. It analyzes whether there are differences related to participants? instruction level, and whether it is possible to identify profiles according to their conceptions. Sixty-eight students from three different levels at 14 Spanish conservatories took part voluntarily in this study. A multiple-choice questionnaire was used, which comprised 16 dilemmas on different situations typical of learning and teaching music. Three answers were presented for each dilemma, corresponding to the three implicit theories identified in recent years: direct, interpretative, and constructive. For each dilemma, participants were requested to choose the option they most agreed with and the one they least agreed with. Data were analyzed using chi-square tests of independence, multiple correspondence analysis, and  ascending hierarchical classification. From the results obtained we can state that as students? age and level of instruction increase, so does the level of sophistication of their conceptions. Three conceptual profiles were identified: direct, direct-interpretative, and constructive, which are consistent with prior results on conceptions of teaching and learning in other domains. Implications for education are discussed.","palabras_clave":"CONCEPTIONS|MUSICAL LEARNING|IMPLICIT THEORIES|MUSIC STUDENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1674,"idioma_id":4,"titulo":"Volcanic Ash Forecast during the June 2011 Cordon Caulle eruption.","resumen":"We model the transport and deposition of ash from the June 2011 eruption at Puyehue-Cordón Caulle volcanic complex, Chile. The modelling strategy, currently under development at the Argentinean Naval Hydrographical Service (SHN) and Argentinean National Meteorological Service (SMN), couples the Weather Research and Forecasting (WRF\/ARW) meteorological model with the FALL3D ash dispersal model. The strategy uses volcanological inputs inferred from satellite imagery, eruption reports, and preliminary grain-size analysis obtained from early sampling done by an Argentine ash sample collection network during the first days of the eruption. In this sense, the results shown here can be regarded as a quasi-syn-eruptive forecast for the first 16 days of the eruption. The model predicts the evolution of the ash cloud, the concentration of ash at relevant flight levels, the expected deposit thickness, and the ash accumulation rates at relevant localities. We validate the modelling strategy by comparing results mainly with satellite retrievals and ground deposit measurements. Results highlight the efficacy of the combined WRF\/ARW-FALL3D forecasting system and points out the usefulness of combining these two models for short-term forecasting of volcanic ash clouds.","palabras_clave":"Cordon Caulle volcanic complex|Meteorological model|Ash cloud forecast|FALL3D model"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1675,"idioma_id":4,"titulo":"Electronic changes at the Pt(1 1 1) interface induced by the adsorption of OH species","resumen":"We perform a detailed analysis of the modifications in the electronic properties when an OH radical adsorbs on Pt(1 1 1). On the basis of first principle calculations, we provide an overview of the interface at the atomic level at low coverages (1\/9 of a monolayer). The electronic factors that govern the adsorption phenomenon are discussed. The interaction of the electronic states involved in the bond formation is investigated. In this context, we examine the charge redistribution and the projected density of states onto the different participating atoms and orbitals. We establish a comprehensive picture which provides a valuable guideline to understand the complicated interplay of the electronic states in the formation of bonds.","palabras_clave":"HYDROXYL|PLATINUM|DENSITY FUNCTIONAL CALCULATIONS|DENSITY OF STATES|CHEMISORPTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1676,"idioma_id":4,"titulo":"Matching Changes in Sensory Evaluation with Physical and Chemical Parameters A Case Study: Argentinean Pistachio Nuts (Pistachia vera L. cv Kerman)","resumen":"Abstract Changes in pistachio nuts induced by roasting and  salting processes, evaluated by both sensory and instrumental  analyses are reported, looking for a match in both methods.  Dried (DP), roasted (RP), and salted?roasted pistachios (SRP)  were studied, including four groups of sensory attributes, six  basic chemical parameters, complemented by volatile organic  compounds (VOCs) and breaking force. Multivariate statistics  helped with data interpretation, enabling correlations between  two groups of variables. Key results show that the perception of  roasting is associated with increased amounts of alpha pinene and  3 carene in RP and SRP, while DP are associated with higher  amounts of limonene, moisture, and bitterness. Sensory and puncture test measurements (texturometer) showed opposite  results, which could be explained considering the loss of plasticity  in RP and SRP. Current results present a novel approach  for the evaluation of changes in the perception of pistachio  quality by consumers, supported by both sensory and instrumental  analyses using multivariate statistics for data evaluation.","palabras_clave":"PISTACHIO NUT .| SENSORY ANALYSIS |VOLATILE COMPOUNDS|MULTIVARIATE STATISTICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1677,"idioma_id":4,"titulo":"ONTOarg: A decision support framework for ontology integration based on argumentation","resumen":"Description Logic Programming (DLP) is a well-known approach to reason with Description Logic (DL)  ontologies, translating them into the language of logic programming (LP). Even though DLP offers several  advantages in terms of efficiency and reuse of existing logic programming tools (such as Prolog environments),  a major hindrance of this approach is its limitation for reasoning in the presence of inconsistent  ontologies. Recent research has led to the use of defeasible argumentation to model different DL reasoning  capabilities when handling inconsistent ontologies, resulting in so-called d-ontologies. In this article  we present ONTOarg, a decision support framework for performing local-as-view integration of possibly  inconsistent and incomplete ontologies in terms of Defeasible Logic Programming (DeLP). We show how  to reason on Description Logics (DL) ontologies in an ontology integration system by performing a dialectical  analysis in order to determine the membership of individuals to concepts. We present formal definitions  of a framework for ontology integration of DL ontologies based on DeLP along with a case study  and review some of the properties of the approach.","palabras_clave":"argumentation|ontologies"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1679,"idioma_id":4,"titulo":"Shiga toxin-producing Escherichia coli in beef retail markets from Argentina","resumen":"Shigatoxin-producingEscherichiacoli(STEC)arefoodbornepathogensthatcausemildorseriousdiseasesandcanleadtopeopledeath.ThisstudyreportstheprevalenceandcharacteristicsofSTECO157andnon-O157incommercialgroundbeefandenvironmentalsamples,includingmeattable,knife,meatmincingmachine,andmanipulatorhands(n=450)obtainedfrom90retailmarketsoveranine-monthperiod.TheSTECisolateswereserotypedandvirulencegenesasstx(Shigatoxin),rfbO157](O157lipopolysaccharide),fliCH7(H7flagellin),eae(intimin),ehxA(enterohemolysin)andsaa(STECautoagglutinatingadhesin),weredetermined.STECO157wereidentifiedin23(25.5%)beefsamplesand16(4.4%)environmentalsamples,whileSTECnon-O157werepresentin47(52.2%)and182(50.5%),respectively.Among54strainsisolated,17wereSTECO157:H7and37wereSTECnon-O157.TheprevalentgenotypeforO157wasstx2\/eae\/ehxA\/fliCH7(83.4%),andforSTECnon-O157themostfrequentoneswerestx1\/stx2\/saa\/ehxA(29.7%);stx2(29.7%);andstx2\/saa\/ehxA(27%).NoneoftheSTECnon-O157strainswereeae-positive.BesidesO157:H7,other20differentserotypeswereidentified,beingO8:H19,O178:H19,andO174:H28theprevalent.Strainsbelongingtothesameserotypecouldbeisolatedfromdifferentsourcesofthesameretailmarket.Also,thesameserotypecouldbedetectedindifferentstores.Inconclusion,screeningtechniquesareincreasinglysensitive,buttheisolationofSTECnon-O157isstillachallenge.Moreover,withtheresultsobtainedfromthepresentwork,althoughmorestudiesareneeded,cross-contaminationbetweenmeatandtheenvironmentcouldbesuspected.","palabras_clave":"STEC |RAWGROUNDBEEF|RETAILMARKETS|ENVIRONMENTALSAMPLES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1682,"idioma_id":4,"titulo":"MATFESA: strain and refractive index field estimation after femtosecond laser interaction with transparent material","resumen":"                                                                                In this paper we   present the development of an open code (MATFESA) based on the Finite   Element Method (FEM) which can be used to estimate the strain and   refractive index fields after femtosecond laser writing process by means   of an iterative analysis. The fs-laser pulse residual stress control is   the key to obtain high performance guiding structures for photonics.                                  The whole complex   physical problem consists in almost three steps inside the material   during\/after femtosecond laser interaction which cannot be analyzed   using thermodynamic equilibrium equations. These are: ionization,   expansion and re-solidification.                                  In the numerical   model solved, a mechanical expansion is introduced in the focal plane to   simulate laser interaction at intensities above the optical breakdown   threshold. Numerical results were compared to experimental measurements   of optical guided modes in LiNbO3 fs-waveguides.                                  The MATFESA model was   compared with ABAQUS commercial software in order to verify the strain   field results and also to test the 2D, plane strain approximation.                                          ","palabras_clave":"femtosecond interaction |strain field|waveguides|index refractive profile"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1683,"idioma_id":4,"titulo":"Analysis of the influence of switching related parameters in the dab converter under soft-switching","resumen":"An analysis of a dual active bridge (DAB) converter under soft-switching mode in the whole operating range is presented in this paper. A detailed study of the impact ofthe transformer magnetizing inductance, LM,and snubber capacitance, Cxx, parameters on the soft-switching regions is carried out to obtain some design considerations. Simulation and experimental results which validate the theoretical analysis are also presented.","palabras_clave":"dc-dc converters|dual active bridge converter|soft switching|modulation strategy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1684,"idioma_id":4,"titulo":"Design, characterization and in vitro evaluation of antifungal polymeric films","resumen":"The objective of the present paper was the development and the fullcharacterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrixformed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol wereused as plasticizing agents. The mechanical properties of films were poorer when the drug wasloaded, probably because crystals of ENC produces network outages and therefore reduces thepolymeric interactions between the polymers. Polymers-ECN and CH-CB interactions wereanalyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis anddifferential thermal analysis (DTA-TGA). ECN did not show structure alterations when loadedinto the films. In scanning electron microphotographs and atomic force microscopy analysis,films prepared with CB showed an evident wrinkle pattern probably due to the stronginteractions between the polymers, which were observed by FTIR and DTA-TGA. The in vitroin vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drugwith the CH activity. All these results suggest that these polymeric films containing ECN arepotential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.","palabras_clave":"DESIGN|CHARACTERIZATION|ANTIFUNGAL|FILMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1686,"idioma_id":4,"titulo":"Determination of tartrazine in beverage samples by stopped-flow analysis and three-way multivariate calibration of non-linear kinetic-spectrophotometric data","resumen":"The performance of MCR-ALS was studied in the modeling of non-linear kinetic-spectrophotometric data acquired by a stopped-flow system for the quantitation of tartrazine in the presence of brilliant blue and sunset yellow FCF as possible interferents.          In   the present work, MCR-ALS and U-PCA\/RBL were firstly applied to remove   the contribution of unexpected components not included in the   calibration set. Secondly, a polynomial function   was used to model the non-linear data obtained by the implementation of   the algorithms. MCR-ALS was the only strategy that allowed the   determination of tartrazine in test samples   accurately. Therefore, it was applied for the analysis of tartrazine in   beverage samples with minimum sample preparation and short analysis   time. The proposed method was validated by comparison with a   chromatographic procedure published in the literature. Mean recovery   values between 98% and 100% and relative errors of prediction values   between 4% and 9% were indicative of the good performance of the method.","palabras_clave":"STOPPED FLOW KINETIC ANALYSIS|SECOND ORDER ADVANTAGE|MCR-ALS|FOOD DYES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1687,"idioma_id":4,"titulo":"Evaluation of a new model for vowels synthesis with perturbations in acoustic parameters","resumen":"Voice signal contains intrinsic irregu-larities which become more evident in the presence of pathologies. The acoustic parameters are very useful for the clinical assessment of voice and pathologies detection. Most existing voice models handle ir-regularities as additive noise and not as information carriers. In this work, a new model is proposed allowing to generate synthesized voices with previously selected acoustical parameters shimmer and jitter. Artificial voices are generated from a glottal source signal, obtained by conveniently disturbing amplitudes and periods, and then filtered using an autoregressive linear filter. Models were developed for amplitude and period perturbations based on statistical methods. Several signals were generated and the performance of the model was analyzed. The quality of synthesized voices was evaluated using an objective quality measurement. The obtained jitter and shimmer values mostly agreed with the theoretically predicted values. These results suggest that this model is useful for artificial voices generation.","palabras_clave":"Vowel Synthesis|Jitter|Shimmer"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1690,"idioma_id":4,"titulo":"Arsenic speciation analysis in mono-varietal wines by on-line ionic liquid-based dispersive liquid-liquid microextraction","resumen":"A highly efficient separation and pre-concentration method for arsenic species determination, based on ionic liquid (IL) dispersive microextraction technique implemented in a flow analysis system, is proposed.Highly selective separation of arsenite species [As(III)] was achieved by chelation with sodium diethyldithiocarbamate (DDTC) followed by dispersion with 40 mg of 1-octyl-3-methylimidazolium hexafluorophosphate&nbsp; IL. Analyte extraction, retention and separation of IL phase were achieved with a packed microcolumn and As(III) was determined in eluent solution by electrothermal atomic absorption spectrometry (ETAAS). Concentration of As(V) was deduced by the difference between total inorganic arsenic and As(III). Thus, determination of total arsenic was performed by previous degradation of organo-arsenic species, followed by a reduction. Under optimal conditions, As(III) extraction efficiency was 100% and a sensitivity enhancement factor of 46 was obtained with only 4.0 ml of sample The method was successfully applied for arsenic speciation studies in mono-varietal wines.","palabras_clave":"arsenic|wine|speciation|ionic liquid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1691,"idioma_id":5,"titulo":"Caracterización de cepas de Lactobacillus spp mediante técnicas fenotípicas y genotípicas","resumen":"El estudio se basa en la identificación de género y especie de cepas de Lactobacillus spp. Se caracterizó cada cepa fenotípicamente por medio de pruebas bioquímicas y API, se puso a punto la técnica de PCR (Reacción en Cadena de la Polimerasa) y finalmente se compararon los resultados obtenidos por ambos métodos. Las primeras caracterizaron las cepas en especies como L. plantarum, aerococcusviridans, acidophilus, rhamnosus y paracasei. Estos datos permitieron seleccionar primers de referencia de especie que se complementaron con generales correspondientes al género. Se determinó que todas las cepas pertenecen al género Lactobacillus spp.,pero sólo un 26,6% coincidieron en el nombre específico de especie. Se concluye entonces que, si bien las pruebas bioquímicas son de importante aplicación en la identificación, las cepas pueden evolucionar, adquirirresistencia o cambiar su metabolismo, lo que implica modificaciones en los patrones de referencia.","palabras_clave":"Lactobacilos|identificación|fenotípica|genotípica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1692,"idioma_id":4,"titulo":"RELATIONSHIP BETWEEN OBESITY DEFINED BY THE PERCENTAGE OF BODY FAT  AND DEFINED BY BODY MASS INDEX IN JUJUY SCHOOL CHILDREN","resumen":"Background: Obesity (OB) is strongly associated with excess body fat.Objective: We analyzed the correlation between the prevalence of OB determined by thepercentage of body fat (BF%) and that obtained by evaluating the BMI, according to internationalstandards.Methods: Data from 15,541 schoolchildren in Jujuy anthropometrically evaluated in a PROSANEprogram (2010-2011) were analyzed. They were grouped by gender and two age groups (5 ? 6years old and 11-12 years old). BMI was calculated and the prevalence of OB was determined asthe cutoff points of IOFT, CDC and WHO references. The BF% was obtained by Deuremberg?sOB equation and boys that exceeded 25% and girls that exceeded 30% were considered OB. Thekappa index was used to determine the agreement between the prevalence of OB obtained fromthe references and the BF%. Agreement was classified as very good (> 0.80), good (0.61 to 0.80),moderate (0.41 to 0.60), fair (0.20 to 0.40) and poor (&#8804; 0.20).Results: Differences in the prevalence of OB between BMI and BF% were, in general, allstatistically significant but the highest (> 21%) occurred using WHO-BMI standard. Regardlessof gender, the agreement was good in all cases except when using WHO-BMI standard, whereit was regular.Conclusion: The OB obtained by IOFT and CDC showed a better relationship with excess body fatdetermined by the BF% than that obtained by the WHO references.Funding: PICTO 2008-00139, ANPCyT, Argentina","palabras_clave":"OBESITY|PERCENTAGE OF BODY FAT | BODY MASS INDEX|SCHOOL CHILDREN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1693,"idioma_id":4,"titulo":"GEOGRAPHICAL ALTITUDE AND RELATIONSHIP BETWEEN BODY MASS INDEX  AND BODY FAT IN JUJUY SCHOOL CHILDREN","resumen":"Background: BMI is the most widely used indicator for estimating nutritional condition because ofits relationship with the percentage of body fat (BF%).Objective: We compared the BF% (calculated using different equations) with BMI in children andadolescents from different altitude levels in Jujuy.Methods: We analyzed anthropometric data from 2670 school children (6-17 years) stratifiedby geographical altitude: Lowlands (LL) ( 2500 m). The BF%was calculated from skinfolds using Siri and Slaughter equations, and BMI with Deurembergequation. We used the Spearman test to evalaute correlation between BF% and BMI usingSPSS software.Results: All comparisons were statistically significant and positive. In the Lowlands (LL) thecorrelation coefficient obtained with Deuremberg?s equation was the highest (0.971), followedby Slaughter (0.641) and Siri (0.433); results in the Highlands (HL) were similar. Valuesobtained with Deuremberg?s equation must be carefully interpreted because that equationderives from BMI. Using the other equations that take into account the skin folds, althoughcorrelations are statistically significant, only explain 18% (Siri) and 41% (Slaughther) of thevariation in BMI.Conclusion: BMI shows the same correlation with BF% regardless of geographic altitude. Theseresults verified studies in other populations, indicating that BMI is an insensitive indicator ofchanges in adiposity in children and adolescents.Funding: PICTO 2008-00139, ANPCyT, Argentina","palabras_clave":"GEOGRAPHICAL ALTITUDE |BODY MASS INDEX|BODY FAT| SCHOOL CHILDREN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1694,"idioma_id":4,"titulo":"A ballistic model for a precessing and orbiting jet with a time-dependent ejection velocity","resumen":"We have found that the ballistic trajectory of a precessing, orbiting and time-dependent velocity jet has a semi-analytical solution. Bipolar, multipolar and S-like morphologies, which are observed in young protoplanetary and planetary nebula (PPN and PN, respectively), can be reproduced by setting different values for the ratio between dynamical time and precession periods, the ratio between the precession and orbital periods, and the jet velocity variability period. We have also computed numerical simulations and find a good agreement with the semi-analytical solution for a jet 103 times denser than the surrounding environment.","palabras_clave":"HYDRODYNAMICS|JETS|OUTFLOWS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1695,"idioma_id":4,"titulo":"Structural and magnetic properties of  Fe2-xCoSmxO4 - nanoparticles and Fe2-xCoSmxO4 - PDMS   magnetoelastomers as a function of Sm content","resumen":"We have synthesized magnetic Fe2-xCoSmxO4 nanoparticles (NPs) by means of the coprecipitation method, varying Sm content from x= 0 to x = 0.5. EDS analysis showed agreement between the metal proportion of the obtained nanoparticles and the stoichiometric mixture of cations used for the synthesis. Part of the particles were heated at 800 °C, and both were characterized by XRD, SEM imaging and magnetization measurements. Physical and magnetic properties were analyzed as a function of Sm content, before and after the heating treatment. A phase segregation is found for the calcined nanoparticles with large Sm content. The magnetic remanence, saturation and coercive field were investigated as a function of Sm content for both heated and unheated (as-prepared) particles. PDMS-NPs magnetoelastomers were prepared and cured under an external uniform magnetic field, obtaining structured anisotropic composites, in which inorganic needles (columnar micrometric structures) oriented in the direction of the magnetic field are formed. Young modulus and remanent magnetic moment were measured and magnetization time relaxation experiments were performed in the directions parallel and perpendicular to the needles in order to determine the magnetic and elastic anisotropy of the composites. The elastic modulus measured parallel to the needles resulted almost twice in magnitude with respect to the perpendicular modulus. The measured magnetic anisotropy of the composites is probably due to the enhanced interparticle interaction within a needle and the freezing of an preferred easy axis distribution among the particles at the curing process.","palabras_clave":"MAGNETOELASTOMERS|MAGNETORHEOELASTOMERS|MAGNETIC NANOPARTICLES|MAGNETIC COMPOSITES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1697,"idioma_id":5,"titulo":"Desarrollo embrionario y retención intrauterina en colúbridos del Nordeste de Argentina","resumen":"En los  reptiles escamosos se reconocen dos modelos de desarrollo: oviparidad y  viviparidad. Estos se consideran parte de un continuo y se ha planteado en  numerosos trabajos que el patrón vivíparo habría evolucionado desde la oviparidad  a través de pasos progresivos que incluyeron: la retención uterina de huevos, el  adelgazamiento de la cáscara y modificaciones en los anexos extraembrionarios y  pared oviductal para la formación de estructuras placentarias. El  conocimiento del grado de desarrollo ontogenético al momento de la puesta de  huevos es fundamental para estimar el tiempo de retención embrionaria  intrauterina.En el  presente trabajo analizamos el estado embrionario en huevos oviductales y  huevos recién puestos de nueve especies del Nordeste de Argentina, con el fin de  evaluar el grado de retención embrionaria y &nbsp;aportar información que contribuya al estudio  de los patrones de desarrollo dentro del clado.","palabras_clave":"ofidios|retenciaon de huevos|estadios embrionarios|oviposición"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1698,"idioma_id":4,"titulo":"Identification and Characterization of a High Affinity Choline Uptake System of Brucella abortus.","resumen":"Phosphatidylcholine (PC), a common phospholipid of the eukaryotic cell membrane, is present in the cell envelope of the intracellular pathogen Brucella abortus, the etiological agent of bovine brucellosis. In this pathogen, the biosynthesis of PC proceeds mainly through the phosphatidylcholine synthase pathway; hence, it relies on the presence of choline in the milieu. These observations imply that B. abortus encodes an as-yet-unknown choline uptake system. Taking advantage of the requirement of choline uptake for PC synthesis, we devised a method that allowed us to identify a homologue of ChoX, the high-affinity periplasmic binding protein of the ABC transporter ChoXWV. Disruption of the choX gene completely abrogated PC synthesis at low choline concentrations in the medium, thus indicating that it is a high-affinity transporter needed for PC synthesis via the PC synthase (PCS) pathway. However, the synthesis of PC was restored when the mutant was incubated in media with higher choline concentrations, suggesting the presence of an alternative low-affinity choline uptake activity. By means of a fluorescence-based equilibrium-binding assay and using the kinetics of radiolabeled choline uptake, we show that ChoX binds choline with an extremely high affinity, and we also demonstrate that its activity is inhibited by increasing choline concentrations. Cell infection assays indicate that ChoX activity is required during the first phase of B. abortus intracellular traffic, suggesting that choline concentrations in the early and intermediate Brucella-containing vacuoles are limited. Altogether, these results suggest that choline transport and PC synthesis are strictly regulated in B. abortus.","palabras_clave":"Phosphatidylcholines|Choline"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1699,"idioma_id":5,"titulo":"Cronología y dieta en la costa atlántica pampeana, Argentina","resumen":"El objetivo de este artículo es evaluar el grado de aprovechamiento de los recursos marinos a lo largo de la historia ocupacional de la región pampeana. Para ello se presentan nuevos fechados radiocarbónicos y análisis de isótopos estables efectuados sobre seis esqueletos humanos recuperados en el litoral marítimo de la provincia de Buenos Aires. Las muestras bioarqueológicas estudiadas proceden de la franja litoral comprendida entre los partidos de General Alvarado y San Cayetano, e incluyen los restos óseos de esqueletos humanos dados a conocer por Ameghino hace más de un siglo. Paralelamente se evalúa la información arqueofaunística disponible para los médanos litorales y su llanura adyacente. Los seis nuevos fechados obtenidos indican la ocupación del litoral interserrano desde el Holoceno temprano-medio (7623-7013 años 14C AP) hasta el Holoceno tardío (2790-1990 años 14C AP). Los análisis isotópicos de &#948;13C y de &#948;15N señalan que la dieta de los individuos del Holoceno temprano-medio fue mixta, centrada en la ingesta de herbívoros terrestres consumidores de vegetales C3 y, en menor proporción, en alimentos marinos. En suma, el estudio isotópico y radiocarbónico realizado, conjuntamente con la evidencia arqueofaunística disponible nos ha permitido discutir la antigüedad, el tipo de alimentación y el uso prehispánico de la costa pampeana. Se concluye que los recursos marinos fueron menos explotados por los cazadores-recolectores en el Holoceno tardío que en el Holoceno temprano-medio.","palabras_clave":"Isotópos Estables|Recursos marinos|Holoceno medio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1700,"idioma_id":4,"titulo":"Overweight and obesity in South America: a critical overview and their relationship to metabolic syndrome, cardiovascular diseases and cancer","resumen":"Socioeconomic and demographic transformations are occurring very rapidly in some areas of the world, especially in South America, and are accompanied by changes in lifestyle, dietary patterns, and the epidemiological profile of prevalent diseases. This review examines whether obesity and overweight are related to metabolic syndrome, cardiovascular disease, and cancer in South America. Research carried out in more than 6,000 cases and controls was evaluated, along with most of the available publications related to South America. In South America, obesity and risk factors for cardiovascular disease are related mainly to aging, ethnicity effects, and preventable risky lifestyle conditions. Most of the studies that found an association between cancer and obesity are from the Southern Cone, the geographic area most affected by this pathology. Overall, the prevalence of metabolic syndrome was highest in Chile, followed in decreasing order by Colombia, Peru, Argentina, and Ecuador, with differences noted between urban and rural areas or between urban and periurban areas. Obesity and cancer may be preventable, at least in part, by healthy behavior; hence, exercise, weight control, and healthy dietary habits are important to reduce the risk of these major chronic diseases.","palabras_clave":"Obesity|Overweight|Non transmissible diseases|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1701,"idioma_id":4,"titulo":"Trophic interactions between two medium-sized mammals: the case of the native Dolichotis patagonum and the exotic Lepus europaeus in a hyper-arid ecosystem","resumen":"As medium-sized herbivores, the exotic Lepus europaeus (European hare) and the native Dolichotis patagonum (mara) have been considered ecological equivalents. These species coexist in Ischigualasto Provincial Park, a hyper-arid ecosystem with scarce food resources. Our objective was to evaluate diet composition, relationship between diets and food availability, and trophic relationships between both herbivores. Collection of feces and vegetation sampling were made in the Mesquite woodland community.  Diet composition was analyzed by microhistological analysis of feces. In both seasons, shrub species represented the most abundant cover type in the area, and annual forbs and grasses appeared in the wet season. Herbivores showed similar dietary ecology: shrubs were the main food items along the year, showing a higher plasticity compared to their diets in other ecosystems, where they selected mostly grasses. The mara selected shrubs such as Atriplex sp. and Prosopis torquata, whereas the European hare selected Cyclolepis genistoides, Atriplex sp., and Bulnesia retama. During the wet season, both herbivores supplemented their diets with grasses and annual forbs. In the dry season, there was increased consumption of cacti, such as Tephrocactus sp. The mara and the European hare are likely close ecological equivalents, in terms of dietary similarity, and they showed strong dietary overlap across the dry season (over 60 %).  Thus, we can assume the existence of a potential trophic competition between mara and European hare, especially during the season when food resources are scarce. These results can be important for the management of drylands in South America, where populations of threatened herbivorous species, such as the mara, coexist with exotic animals, sharing spatial and trophic resources even in protected areas.","palabras_clave":"Diet overlap |Diversity|European hare| Mara"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1703,"idioma_id":5,"titulo":"Efectos de la gravedad y de fuerzas moleculares de corto y largo alcance sobre la morfología de gotas","resumen":"http:\/\/anales.fisica.org.ar\/journal\/index.php\/analesafa\/article\/view\/1932\/1979","palabras_clave":"Disjoining pressure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1704,"idioma_id":5,"titulo":"Tracción Biaxial no equilibrada con una maquina de acopado hidraulico","resumen":"RESUMEN Existen diagramas que muestran las deformaciones límites que pueden soportar las chapas de acero en su plano cuando son conformadas. Los límites indicados por ellos están en correspondencia con las distintas aptitudes para estampado que exhibe cada material.- Estos diagramas se conocen como Diagramas Límites de Conformado (DLC). Para la confección de estos diagramas mediante ensayos, se reproducen distintos caminos de deformación que permitan obtener datos para su trazado.- En el Laboratorio de Metalurgia de la U.N.S. se cuenta con un equipo de acopado hidráulico diseñado originalmente para lograr la tracción biaxial equilibrada de una probeta, empleando para ello una máscara de abertura circular.- Mediante ensayos de acopado hidráulico es factible reproducir caminos de deformación ubicados en el cuadrante derecho de dicho diagrama (ambas deformaciones positivas), es decir, tracción biaxial equilibrada y no equilibrada.- En este trabajo, se buscó la manera de adaptar dicho equipo para la obtención de trayectorias de tracción biaxial no equilibradas.- Para alcanzar este objetivo, se diseñaron máscaras de sujeción de la probeta con abertura elíptica.- El camino de deformación queda así supeditado a la relación de los semiejes de la elipse.- Como con el primer diseño de la máscara, la probeta se deformaba fuera del área de la elipse, se modificó el sistema de anclaje de la misma para lograr que la deformación quedara circunscripta al área de la abertura elíptica.-","palabras_clave":"ACOPADO HIDRÁULICO|CHAPAS DE ACERO|DIAGRAMA LÍMITE DE CONFORMADO|TRACCIÓN BIAXIAL NO EQUILIBRADA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1707,"idioma_id":5,"titulo":"¿Por qué la Legislación no Protege a los Bosques Nativos de Argentina? Conflictos Socioambientales y Políticas Públicas en la Provincia de Córdoba","resumen":"                    Tomando la perspectiva de la ecología política, el  artículo analiza los conflictos socioambientales que contextualizaron la  sanción de la Ley  de Ordenamiento Territorial de Bosques Nativos de la Provincia de Córdoba  (Ley 9814\/2010). Se caracterizan a los actores sociales en disputa y sus  lógicas e intereses en juego y se analizan los argumentos que justificaron las  posiciones que asumieron durante el conflicto que precedió a la sanción de la Ley. Se identifican las  alianzas generadas a fin de constituir grupos de interés para accionar  políticamente en la arena legislativa, y se contextualiza la disputa  local\/provincial en el modelo agropecuario dominante a nivel nacional\/global. El  trabajo concluye que la ley expresa una alianza de poder consolidada  históricamente entre los sectores hegemónicos de poder económico y político  local, quienes usan y construyen el marco institucional del Estado en su propio  beneficio sin importar los costos ambientales y sociales. Esta alianza  contribuye a debilitar las demandas y derechos de los sectores más vulnerables  de la sociedad, desconoce los procesos de participación ciudadana, y compromete  la oferta futura de servicios ambientales por parte del bosque nativo.","palabras_clave":"CONFLICTOS ECOLOGICOS DISTRIBUTIVOS|LEY DE BOSQUES|POLITICAS AMBIENTALES|MODELOS DE DESARROLLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1708,"idioma_id":5,"titulo":"Turismo e investigación: ¿en camino hacia replanteos teóricos?","resumen":"El estudio se concentró en el período comprendido entre 2001 y 2008 en nuestro país. Su principal anclaje estuvo centrado en la producción efectuada por los docentes-investigadores dependientes de las universidades públicas miembros del CONDET. Se trata de un estudio interpretativo, abordado desde la perspectiva teórica metodológica de la teoría de los campos (Bourdieu, P. 1988). Su Objetivo General fue objetivar las representaciones y perspectivas existentes en el turismo como campo de investigación, emanadas de las posiciones que ocupaban los agentes productores.","palabras_clave":"TURISMO|CAMPO DE INVESTIGACIÓN|DISCIPLINAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1709,"idioma_id":5,"titulo":"Actualidad en Derecho de Familia","resumen":"Comentario a los Fallos de los Tribunales de Familia de la provincia de Córdoba.","palabras_clave":"Actualidad.|Derecho.|Familia.|Derecho de Familia."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1710,"idioma_id":4,"titulo":"Biophysical Characterization of the Membrane-proximal Ectodomain of the Receptor-type Protein-tyrosine Phosphatase Phogrin","resumen":"The receptor-type protein-tyrosine phosphatase (RPTP) phogrin is localized at the membrane of secretory granules of pancreatic islet ;-cells and, similarly to the closely related ICA512, plays a role in the regulation of insulin secretion, in ensuring proper granulogenesis and stability, and in the regulation of -cell growth. The mature membraneproximal ectodomain of phogrin (MPE phogrin) was produced as a recombinant protein and characterized. CD, fluorescence, controlled proteolysis, size-exclusion chromatography, and multi-angle light scattering showed that it is a properlyfolded monomeric domain. Equilibrium experiments, in the presence of guanidinium chloride and thermal unfolding, suggest a two-state mechanism with a G of 2.3-3.3 kcal\/mol, respectively. The study establishes common features and differences of MPE phogrin and the homologous ectodomain of ICA512. A homology model of phogrin was built based in the x-ray structure of MPE ICA512. The model is a starting point for modeling the entire receptor and for testing the quaternary structure and interactions of this protein in vivo. A description of the membrane insertion mode and putative interacting surfaces of this large protein is fundamental for the understanding of its biological function.","palabras_clave":"Diabetes|equilibrium unfolding|homology modeling|phogrin|receptor-type protein-tyrosine phosphatase|secretory granule"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1712,"idioma_id":4,"titulo":"Growth inhibition in rats fed inadequate and incomplete proteins: repercussion on mandibular biomechanics","resumen":"AbstractObjectiveThe present study describes the effects of feeding growing rats with diets containing increasing concentrations of wheat gluten (a low quality protein, G) on both the morphometrical and the biomechanical properties of the mandible.DesignFemale rats were fed one of six diets containing different concentrations (5\u201330%) of G between the 30th and 90th days of life. Control rats were fed a diet containing 20% casein (C), which allows a normal growth and development of the bone. Mandibular growth was estimated directly on excised and cleaned bones by taking measurements between anatomical points. Mechanical properties of the right hemimandibles were determined by using a three-point bending mechanical test to obtain a load\/deformation curve and estimate the structural properties of the bone. Bone material properties were calculated from structural and geometric properties. The left hemimandibles were ashed and the ash weight obtained. Calcium content was determined by atomic energy absorption. Results were summarised as means ± SEM. Comparisons between parameters were performed by ANOVA and post-test.ResultsNone of the G-fed groups could achieve a normal growth performance as compared to the C-fed control group. Like body size, age-related increments in mandibular weight, length, height and area (index of mandibular size) were negatively affected by the G diets, as was the posterior part of the bone (posterior to molar III). The cross-sectional geometry of the mandible (cross-sectional area and rectangular moment of inertia) as well as its structural properties (yielding load, fracture load, and stiffness) were also severely affected by the G diets. However, material properties (Young's modulus and maximum elastic stress) and calcium concentration in ashes and the degree of mineralisation were unaffected.ConclusionsThe differences in strength and stiffness between treated and control rats seemed to be the result of an induced loss of gain in bone growth and mass, in the absence of changes in the quality of the bone mineralised material.","palabras_clave":"MANDIBLE|BONE|BIOMECHANICS|NUTRITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1713,"idioma_id":5,"titulo":"ANÁLISIS AUTOMÁTICO MORFOLÓGICO CON LAS HERRAMIENTAS  SMORPH Y NOOJ","resumen":"La morfología ha tenido un gran desarrollo dentro de la Lingüística Computacional porque es la base para poder realizar investigaciones en los otros niveles de representación. En esta ocasión trabajaremos con N(nombres) y A (adjetivos), presentaremos la lógica operativa de cada herramienta marcando lo que tienen en común y sus particularidades. Las operaciones que efectúa SMORPH son la sustracción y la concatenación al final de una cadena, por lo tanto, para la formalización de la morfología de los nombres se trabajará con el lema y terminaciones. NooJ comparte con Smorph el uso de las operaciones de sustracción y concatenación al final de una cadena, pero además actúa sobre lugares a determinar por el usuario se trate del comienzo o fin de palabra y tiene la posibilidad de indicar la dirección (izquierda o derecha). No solamente sustrae o concatena sino además puede cambiar o duplicar caracteres.Para la construcción de las gramáticas morfológicas y los diccionarios de NOOJ recurriremos al diccionario (entradas) que ya ha trabajado el equipo INFOSUR","palabras_clave":"OPERACIÓN |SUSTRACCIÓN|CONCATENACIÓN|GRAMÁTICAS\/DICCIONARIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1714,"idioma_id":4,"titulo":"Use of generalized hyperspherical Sturmian functions for a three-body break-up model problem","resumen":"A hyperspherical Sturmian approach recently developed for three-body break-up processes istested through an analytically solvable S-wave model. The scattering process is represented bya non-homogeneous Schr¨odinger equation in which the driven term is given by aCoulomb-like interaction multiplied by the product of a continuum wavefunction and a boundstate in the particles? coordinates. The model contains most of the difficulties encountered in areal three-body scattering problem, e.g., non-separability in the electrons? sphericalcoordinates and Coulombic asymptotic behaviour, and thus provides an interesting benchmarkfor numerical methods. Since the Sturmian basis functions are constructed so as to include thecorrect asymptotic behaviour, a very fast convergence of the scattering wavefunction isobserved. Excellent agreement is found with the analytical results for the associated transitionamplitude. This holds true down to very low energies, a domain which is usually challengingas it involves huge spatial extensions. Within our method, such calculations can be performedwithout increasing significantly the computational requirements.","palabras_clave":"Hyperspherical|Sturmians|Ionization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1715,"idioma_id":4,"titulo":"Phytochemical resistance-traits in crops against pests and diseases","resumen":"The phytochemical-resistance trait comprises of is one or more compounds produced by the crop for resistance against pests and diseases. Breeding for phytochemical resistance-traits may offer more stable crop resistance and less dependance on pesicides. Nevertheless, incorporation of phytochemical resistancetraits in crop improvement faces several problems viz., monitoring during breeding process and their biological impact on agroecosystems. This Paper describes several methods for easy monitoring of phytochemical resistance-traits in crop species, including the rapid and often cheap assays to measure contents of glucosinolates, cyanogenic glycosides, phenylpropanoids, alkylresorcinols, resveratrol, salicylic acid and activity of phenylalanine ammonia-lyase. These methods should be used complementary to visual traits of resistance such as ratings of disease, or insect feeding. They can provide a better understanding of the underlying mechanisms involved in crop defense to pests and diseases.","palabras_clave":"PHYTOCHEMICALS|CROPS|GLUCOSINOLATES|DISEASES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1717,"idioma_id":5,"titulo":"Mortalidad por causas externas: un problema de salud pública. Argentina, Chile y Colombia. 2000- 2008","resumen":"Se realizó un estudio descriptivo de la mortalidad por causas externas en la población argentina,chilena y colombiana durante el período 2000-2008. Se analizaron las muertes por homicidios,suicidios y accidentes de tránsito, en función de la edad y sexo. Se observó una reducción delriesgo de morir por estas causas en el segundo trienio. Hubo diferencias en la mortalidad por sexoy edad dependiendo la causa externa de muerte. Los mayores niveles de mortalidadcorrespondieron a los homicidios, seguidos por los accidentes de tránsito y por último lossuicidios. Se registró sobremortalidad masculina en los tres países seleccionados.","palabras_clave":"mortalidad|violencia|causas externas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1718,"idioma_id":4,"titulo":"Interaction among experience, teaching performance and student's learning at university level","resumen":"                                                    This experimental study approaches characteristics of three university teachers? classes with different levels of experience. According to the literature, experienced teachers more often than not are adaptable to different contexts. However, novice teachers are usually focused on specific class contents to be evaluated. Three teachers were selected, a Professor, and two Assistants (a university level one and an undergraduate). We gave them a source-text to teach 10 students each one. After that, students? knowledge was evaluated with a post-test and a self-evaluation. The characteristics of the three classes were evaluated by external judges and the students themselves. Moreover, theme and sequential submission analyses following the source-text were made. Results show differences in each of the analyzed aspects according to the literature.                   ","palabras_clave":"Knowledge level|Teaching|Learning"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1719,"idioma_id":5,"titulo":"Consumos culturales en Argentina","resumen":"Este trabajo presenta los estudios sobre consumos culturales realizadosen Argentina, enfocando especialmente en los últimos treinta años. Hemosconsiderado trabajos que investigaron sobre públicos de arte, asistencia amuseos y otras instituciones, lectura de libros e impresos, asistencia a cines,teatros, espectáculos musicales y festivales,&nbsp;etc. Nos proponemos indagar acerca de los objetos de estudio delimitadosen esos trabajos, así como bosquejar los contextos en los que se han formuladolíneas de investigación con enfoques particulares. También procuramospuntualizar algunas de las temáticas que fueron abordadas, destacar sus aportesal conocimiento de fenómenos específicos y ponderar las posibilidades deformular una sistematización general sobre el campo en cuestión. La mayoría delas investigaciones son de tipo cuantitativo, cubriendo diferentes espaciosgeográficos del país, empleando distintas variables, y no han conformado seriescomparables. Los estudios cualitativos se han concentrado en algunos tópicospuntuales, destacándose los consumos musicales y juveniles. No ha habidoindagaciones que pongan en relación los estudios cualitativos con lasinvestigaciones cuantitativas. Los principales estudios son los más recientes yhan sido realizados desde la administración pública nacional y en menor medidadesde las universidades.","palabras_clave":"consumos culturales|politicas culturales|museos|juventud"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1720,"idioma_id":4,"titulo":"Development of electrospun nanofibers for biomedical applications: state of the art in Latin America","resumen":"Electrospinning is a powerful processing technique with huge potential in many attractive and cutting-edge research fields. This technique allows the production of nonwoven micro\/nanofibrous materials, including polymers, ceramics and metals, with a wide range of morphologies and functionalities. The highly porous electrospun scaffolds are ideal for biomedical applications, in particular for tissue engineering and  drug delivery of biologically active compounds. In this review, we summarize the works on electrospun micro\/nanofibers for biomedical applications carried out by research groups from Latin American countries. Studies are mainly focused on nanofibrous polymeric systems for drug delivery of therepeutic and bioactive agents, tissue engineering scaffolds and sensors, as well as other biomedical applications.","palabras_clave":"nanofibers|electrospinning|tissue engineering|drug delivery systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1721,"idioma_id":4,"titulo":"Hoarding patterns of sigmodontine rodent species in the  Central Monte desert (Argentina)","resumen":"doi:10.1111\/j.1442-9993.2012.02438.x    Abstract Hoarding food is an important strategy of rodents in desert environments characterized by unpredictable  and poor food resource availability. In the Monte Desert, Prosopis produces abundant food, unevenly in time  and space, in the form of pods and seeds. Sigmodontine rodents (Graomys griseoflavus,Akodon molinae, Eligmodontia  typus and Calomys musculinus) use Prosopis propagules extensively, and they could be predators or dispersers  depending on how they handle and where they leave the propagules.The objectives of this study were: (1) to know  what rodent species transported propagules; (2) to evaluate what hoarding pattern was used by species that  transport propagules (larder and scatterhoarding); and (3) to analyse in which condition were propagules left by the  rodent species, both at the food source and in caches. Our results showed that all four species transported  propagules, with G. griseoflavus and E. typus being the species that carried more seeds. Our study supported the  evidence that food caching is common among species and that many species both larderhoard and scatterhoard  food. Graomys griseoflavus and A. molinae, the largest species, larderhoarded more than did the smaller E. typus.  These results uphold the hypothesis that larger species will show greater propensity to larderhoard than smaller  species. Considering the interaction between seed-hoarding patterns and plants, E. typus was the species that could  most improve germination because it scatterhoarded propagules and left seeds out of pods. In contrast,  G. griseoflavus could have a negative impact on plant populations because this was the species that predated more  seeds and larderhoarded a high percentage of them. The smallest C. musculinus was the species that transported  propagules least, and left them as seeds inside pods or pod segments mainly at the food source, which makes seeds  more vulnerable to predation.  Key words: disperser, larderhoarding,","palabras_clave":"HOARDING|RODENTS|PREDATION|DISPERTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1722,"idioma_id":4,"titulo":"An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2.","resumen":"Abstract: Polypeptide GalNAc-transferases (ppGalNAc-Ts)are a family of enzymes that catalyze the initiation of mucintypeO-glycosylation. All ppGalNAc-T family memberscontain a common (QXW) 3 motif, which is present in theR-type lectin group. The acetylation site K521 is part of theQKW motif of &#946; -trefoil in the lectin domain of ppGalNAc-T2. We used a combination of acetylation and site-directedmutagenesis approaches to examine the functional roleof K521 in ppGalNAc-T2. Binding assays of non-acetylatedand acetylated forms of the mutant ppGalNAc-T2 K521Q tovarious naked and &#945; GalNAc-glycosylated mucin peptidesindicated that the degree of interaction of lectin domainwith &#945; GalNAc depends on the peptide sequence of mucin.Studies of the inhibitory effect of various carbohydrates onthe interactions of ppGalNAc-T2 with MUC1 &#945; GalNAc indicatethat point K521Q mutation enhance the carbohydratespecificity of lectin domain for &#945; GalNAc. K521Q mutationresulted in an enzyme activity lower than that of the wildtypeppGalNAc-T2, similar to the acetylation of ppGalNAc-T2. We conclude that an acetylation site in the QKW motifof the lectin domain modulates carbohydrate recognitionspecificity and catalytic activity of ppGalNAc-T2 forpartially preglycosylated acceptors and a certain nakedpeptide. Posttranslational modifications of ppGalNAc-Ts, such as acetylation, may play key roles in modulatingthe functions of the R-type lectin domains in cellularhomeostasis.","palabras_clave":"ACETYLATION SITE|CARBOHYDRATE SPECIFICITY|GLYCOSYLTRANSFERASE ACTIVITY|LECTIN DOMAIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1723,"idioma_id":4,"titulo":"Synthesis, Structural Study and Spectroscopic Characterization of a Quinolin-8-Yloxy Derivative with Potential Biological Properties","resumen":"We have prepared the (5-chloro-quinolin-8-yloxy) acetic acid and characterized it by using infrared, Raman and multi- dimensional nuclear magnetic resonance spectroscopies. The density functional theory (DFT) together with the 6-31G* and 6-311++G** basis sets were used to study its structure and vibrational properties. Three stable conformations of the compound were theoretically determined in gas phase and probably these conformations are present in the solid phase. The harmonic vibrational wavenumbers for the optimized geometries were calculated at the same theory levels. For a complete assignment of the observed bands in the vibrational spectra, the DFT calculations were combined with Pulay\u2019s scaled quantum mechanical force field (SQMFF) methodology in order to fit the theoretical wavenumber values to the experimental ones. Besides, the force constants of the three conformers of (5-chloro-quinolin-8-yloxy) acetic acid were calculated and compared with those obtained by us for the 2-(quinolin-8-yloxy) acetic acid. In addition, the characteris- tics of the electronic delocalization of those structures were performed by using natural bond orbital (NBO), while the corresponding topological properties of electronic charge density are analysed by employing Bader\u2019s atoms in mole- cules theory (AIM).","palabras_clave":"(5-Chloro-Quinolin-8-Yloxy) Acetic Acid|Vibrational Spectra|Molecular Structure|Force Field|DFT Calculations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1724,"idioma_id":5,"titulo":"Efecto del almacenamiento a - 20 ºC de quesos semiduros de leche de oveja envasados al vacío, sobre su perfil sensorial.","resumen":"El objetivo de esta investigación fue analizar el efecto del almacenamiento de quesos de leche de  oveja de 45 d de maduración envasados al vacío, a -20ºC durante 90 y 180 d, sobre su perfil sensorial. Se  determinó también, el contenido de materia grasa, proteína total y humedad de los quesos antes de la  congelación y a los 90 d de almacenamiento congelado. Un panel de evaluadores entrenados analizaron,  mediante el método de análisis descriptivo cuantitativo, 15 descriptores sensoriales: olores a oveja y frutos  secos, sabores salado y ácido, intensidad de aroma, aromas a manteca y a oveja, sensación picante, persistencia,  elasticidad, dureza, friabilidad, solubilidad, adherencia y cremosidad, en una escala de intensidad de siete  puntos. La conservación de los quesos a -20ºC produjo cambios sobre su perfil sensorial, observándose  diferencias significativas (P0.05) en las  variables químicas analizadas a los tres meses de almacenamiento. En conclusión, las modificaciones de los  descriptores sensoriales a los tres meses de almacenamiento congelado tuvieron un efecto mínimo sobre el  perfil sensorial, y los defectos aparecieron mayormente los seis meses. Por lo tanto, quesos de oveja de 45 d de  maduración envasados al vacío podrían almacenarse con seguridad durante tres meses a -20ºC.","palabras_clave":"CONGELADO|SENSORIAL|QUESO|OVEJA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1725,"idioma_id":5,"titulo":"Entornos Virtuales de Aprendizaje en la educación superior: riesgos y promesas. Claves para el diseño e implementación de aulas virtuales y extendidas","resumen":"En un mundo globalizado los centros universitarios proponen a sus estudiantes diferentes alternativas para completar carreras de grado y posgrado. Sin lugar a dudas la educación semipresencial y a distancia ha adquirido un protagonismo sin precedentes. Nuestra Universidad Nacional de Tucumán consciente del protagonismo alcanzado por estas nuevas modalidades insta a sus unidades académicas a efectuar las gestiones necesarias para asumir los desafíos inherentes.  A partir de la creación del CEDITE (Centro de Educación a Distancia e Investigación en Tecnologías Educativas) en la facultad de Ciencias Exactas y Tecnología, se ha iniciado un camino para la implementación de la modalidad virtual.  La puesta en marcha del ?Plan Estratégico para la inserción de TICs en procesos educativos y la implementación de la Educación a Distancia en la FACET?, en sus distintas áreas, ha permitido la implementación del Entorno Virtual, destinado a la gestión de Aulas Extendidas para las cátedras que lo requiriesen.   El primer objetivo, entonces, es presentarles esta propuesta y los alcances esperados de la misma. En segundo lugar exponer la fundamentación e importancia de los entornos virtuales de los centros de altos estudios, como también las destacadas derivaciones del uso de los mismos. Finalmente proponemos algunas claves para el diseño e implementación de Aulas Virtuales en entornos de aprendizaje.","palabras_clave":"plataforma|virtual|educacion|aprendizaje|e-learning|grado|posgrado|aula|virtuales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1726,"idioma_id":4,"titulo":"Negative interaction between twospotted spider mites and aphids mediated by feeding damage and honeydew","resumen":"Among the herbivorous arthropods that feed onstrawberry, the most important are the two-spotted spider mite (TSSM),Tetranychus urticae Koch, and several species of aphids. Mites and aphidsbelong to different guilds that coexist in the field and feed on the undersidesof strawberry leaflets. However, the occurrence of large numbers of individualsof both species on the same leaflet is rarely recorded. We hypothesize thatnegative interactions between TSSM and aphids explain the intra plantdistribution of these herbivores. We first examined the spatial coincidence ofboth herbivores in the field. Under experimental conditions, we then analyzed:(i) the rate of increase of TSSM and the aphid Chaetosiphon fragaefolii(Cockerell), growing individually and together; (ii) the effect of honeydew onTSSM preference; and (iii) the effect of previous strawberry leaflet damage byTSSM on C. fragaefolii preference. The proportion of TSSM that coincided withat least one aphid decreased as the percentage of leaflets with TSSM increased.The spatial coincidence index between aphids and TSSM increased together withthe percentage of TSSM-infested leaflets. TSSM showed both a lower rate ofincrease when they shared the same leaflet with C. fragaefolii and lowerfecundity on strawberry discs with honeydew. The rate of increase of C.fragaefolii did not change on co-occupied leaves, but the aphid species movedto the other side of leaflets shared with TSSM. Negative interactions resultingin a tendency for species to avoid each other, such as demonstrated herein, canaffect distribution and performance of herbivorous arthropods.","palabras_clave":"Tetranychus urticae|Chaetosiphon fragaefolii|negative interactions|strawberry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1728,"idioma_id":4,"titulo":"Social and environmental health determinants and their relationship with parasitic diseases in asymptomatic children from a shantytown in Buenos Aires, Argentina","resumen":"Health inequities are a common problem for all countries and are the result of not only adverse social conditions but also poor public policies. Today chronic diseases represent the most relevant threats and are a current challenge. Parasitic infections, a leading cause of child morbidity affecting low-income populations, can be transmitted because of an unhealthy environment. Notwithstanding, scarce data have been published on the epidemiological profile of intestinal parasitoses in asymptomatic children living in shantytowns. Vulnerable populations settled in slums are growing in Argentina, particularly in Buenos Aires city. Consequently, this work intended to screen healthy carriers of enteric parasites and determine the epidemiologic profile in asymptomatic children residing in one of those communities, to explore risk factors associated with the transmission of parasites, and to initiate a basic health education campaign to promote healthy behavior in the community. Fecal samples (n&nbsp;=&nbsp;138) were analyzed by conventional parasitological methods and a survey gathered data on symptoms, family composition, and environmental and hygiene-related variables. High prevalence of feco-orally-transmitted parasitoses (83·3%) and polyparasitism were remarkable findings. The main environmental health determinants were those related to excreta disposal and water provision. Health promotion actions were performed through the diffusion of a set of posters with iconic images and brief messages for health education.Results suggest the need for an environmental sanitation policy to complement health promotion actions. It is essential to spread the results of investigations that address inequities and social determinants of health in order to integrate data with local political processes and alert on acceptable actions for developing appropriate interventions. ","palabras_clave":"INTESTINAL PARASITOSES|ASYMPTOMATIC CHILDREN |VULNERABLE POPULATIONS|URBAN HEALTH|ENVIRONMENTAL AND PUBLIC HEALTH|SOCIAL AND HEALTH DETERMINANTS|SHANTYTOWN|RISK ASSESMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1729,"idioma_id":4,"titulo":"Baclofen did not modify sexually dimorphic c-Fos expression during morphine withdrawal syndrome","resumen":"In previous studies we have reported sex-related differences during  morphine withdrawal. We have also shown that the GABAB agonist  baclofen was able to prevent the morphine withdrawal syndrome in male  as well as in female mice. Considering that early gene expression is  induced by drugs of abuse, we evaluated the expression of c-Fos in several brain areas, in mice of either sex during naloxone-precipitated withdrawal,and after pretreatment with baclofen. Swiss-Webster prepubertal mice were rendered dependent by i.p. injection of morphine (2 mg\/kg), twice daily for 9 days. On the 10th day, dependent mice were divided into two groups: the withdrawal group received naloxone (6 mg\/kg, i.p.) after the last dose of morphine, while the prevention group received baclofen (2 mg\/kg, i.p.) before naloxone. Thirty min after naloxone, animals were sacrificed by transcardial perfusion. Brains were removed and slices were obtained to perform immunohistochemical studies. Our results show a significant decrease in c-Fos expression in hippocampal dentate gyrus, CA3 and CA1 areas of morphine withdrawn males, vs their control group. Conversely, in females, the number of c-Fos positive nuclei was not modified in any of the areas studied. Baclofen pretreatment had no effect on the decreased c-Fos expression in morphine withdrawn males. The sexual dimorphism observed here confirms the greater sensitivity of males over females in their response to morphine. The preventive action of baclofen on the expression of morphine withdrawal would not be related to an effect on c-Fos expression.","palabras_clave":"Opiates|GABA(B) receptors|early gene expression|Sex differences|Mice"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1730,"idioma_id":4,"titulo":"DMT1 as a Candidate for Non-Transferrin-Bound Iron Uptake in the Peripheral Nervous System","resumen":"Iron, either in its chelated form or as holotransferrin (hTf), prevents the dedifferentiation of Schwann cells (SC), cells responsible for the myelination of the peripheral nervous system (PNS). This dedifferentiation is promoted by serum deprivation through cAMP release, PKA activation and CREB phosphorylation. Since iron elicits its effect in a transferrin (Tf)-free environment, in the present work we postulate that non-transferrin-bound iron (NTBI) uptake must be involved. Divalent metal transporter 1(DMT1) has been widely described in literature as a key player in iron metabolism, but never before in the peripheral nervous system (PNS) context. The presence of DMT1 was demonstrated in nerve homogenate, isolated adult-rat myelin and cultured SC by Western Blot (WB) analysis and confirmed through its co-localization with S-100&#946; (SC marker) by immunocytochemical and immunohistochemical analyses. Furthermore, the existence of its mRNA was verified in sciatic nerve homogenate by RT-PCR and throughout SC maturational stages. Finally, we describe DMT1?s subcelullar location in the plasma membrane by confocal microscopy of SC and WB of different subcellular fractions. These data allow us to suggest the participation of DMT1 as part of a Tf independent iron uptake mechanism in SC and lead us to postulate a crucial role for iron in SC maturation and, as a consequence, in PNS myelination.","palabras_clave":"DMT1|IRON|PERIPHERAL NERVOUS SYSTEM|MYELINATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1731,"idioma_id":4,"titulo":"Measurement of the ttbar production cross section in the tau+jets channel using the ATLAS detector","resumen":"A measurement of the top quark pair production cross   section in the final state with a hadronically decaying tau lepton and   jets is presented. The analysis is based on proton-proton collision data   recorded by the ATLAS experiment at the LHC, with a centre-of-mass   energy of 7 TeV. The data sample corresponds to an integrated luminosity   of 1.67 inverse femtobarns. The cross section is measured to be 194 +\/-   18 (stat.) +\/- 46 (syst.) pb and is in agreement with other   measurements and with the Standard Model prediction.A measurement of   the top quark pair production cross section in the final state with a   hadronically decaying tau lepton and jets is presented. The analysis is   based on proton\u2013proton collision data recorded by the ATLAS experiment   at the LHC, with a centre-of-mass energy of 7&nbsp;TeV. The data sample   corresponds to an integrated luminosity of 1.67&nbsp;fb(&#8722;1). The cross   section is measured to be and is in agreement with other measurements   and with the Standard Model prediction.  ","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1733,"idioma_id":4,"titulo":"PLASMON SPECTROSCOPY FOR SUBNANOMETRIC COPPER PARTICLES: DIELECTRIC FUNCTION AND CORE-SHELL SIZING","resumen":"In the last years, there has been a growing interest in the study of transition metal nanoparticles (Nps) due to their potential applications in several fields of science andtechnology. In particular, their optical properties are governed by the characteristics of the dielectric function of the metal, its size and environment. This work analyses the separated contribution of free and bound electrons on the optical properties of copper Nps. Usually, the contribution of free electrons to the dielectric function is corrected for particle size through the modification of the damping constant, which is changed as usual introducing a term inversely proportional to the particle´s radius to account for the extra collisions with the boundary when the size approaches the electronic mean free path limit (about 10 nm). For bound electron contribution, the interband transitions from the dband to the conduction band are considered together with the fact that the electronic density of states in the conductionband must be made size-dependent to account for the larger spacing between electronic energy levels as the particle decreases in size below 2 nm. Taking into account these specific modifications of free and bound electron contributions to the dielectric function, it was possible to fit the bulk complex dielectric function, and consequently, determine optical parameters and band energy values such as the coefficient for bound electron contribution Qbulk = 2e24, gap energy Eg = 1.95 eV, Fermi energy EF = 2.15 eV, and damping constant for bound electrons &#947;b = 1.15e14 Hz.With both size-dependent contributions to the dielectric function, extinction spectra of copper Nps in the subnanometer radius range can be calculated using Mie´s theory and its behaviour with size can be analysed. These studies are applied to fit experimental extinction spectra of very small spherical core-shell Cu-Cu2O Nps generated by ultrafast laser ablation of a solid target in water. Theoretical calculations for subnanometric core radius are in excellent agreement with experimental results obtained from core-shell colloidal Nps. From the fitting, it is possible determining core radius and shell thickness of the Nps, showing that optical extinction spectroscopy is a good complementary technique to standard high-resolution electron microscopy for sizing spherical nanometric-subnanometric Nps.","palabras_clave":"copper nanoparticles |dielectric function|plasmon spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1734,"idioma_id":4,"titulo":"Disputed Rulership in Upper Egypt: Reconsidering the Second Stela of Kamose (K2)","resumen":"The Second Stela of Kamose (K2) has received a wide spectrum of analyses from different points of view. This paper presents a discussion on the use of the title Heqa and on the conception of the social bonds sustained by the Hyksos ruler as preserved in the text.            Nota: Se deja constancia que el artículo fue publicado en el año 2013 pero debido a que la revista estaba atrasada en su edición, fue publicada en el vol. 38 al que correspondían los años 2011-12 (revista publicada como número doble).Se adjunta certificación.","palabras_clave":"KAMOSE|SECOND INTERMEDIATE PERIOD|HYKSOS|RULERSHIP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1735,"idioma_id":5,"titulo":"MORFOLOGÍA E HISTOLOGÍA DE OSTEODERMOS DE UN PEIROSAURIDAE DE LA CUENCA NEUQUINA","resumen":"Se describen osteodermos de un nuevo ejemplar de crocodyliforme hallado en un afloramiento correspondiente a niveles de la Formación Plottier (Coniaciano tardío) de la localidad de Puesto Hernández, en inmediaciones de la localidad de Rincón de los Sauces, Provincia del Neuquén. Los osteodermos estudiados, que son parte del material hallado, están integrados por: región dorso-sacra, osteodermos apendiculares asociados al fémur derecho, región proximoventral de osteodermos caudales articulados y osteodermos aislados. La histología de los osteodermos permitió determinar que están constituidos por una corteza compacta que circunda una región interna más porosa. Fue posible reconocer marcas de crecimiento (annuli) en prácticamente todo el tejido compacto, pudiendo determinarse una edad mínima de 18 años para el espécimen estudiado. Los osteodermos exhiben caracteres que permiten preliminarmente asignar al ejemplar MAU-Pv-PH-437, como un Mesoeucrocodylia cercanamente relacionado con Peirosauridae.","palabras_clave":"Crocodyliforme|Mesoeucrocodylia|Osteodermos|Histología"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1736,"idioma_id":4,"titulo":"Chloride anion effect on the advanced oxidation processes of methidathion and dimethoate: Role of Cl2.-  radical","resumen":"The reaction of phosphor-containing pesticides such as methidathion (MT) and dimethoate(DM) with dichloride radical anions ðClðCl2Þ was investigated. The second order rateconstants (1.3  0.4) 108 and (1.1  0.4) 108 M1 s1 were determined for the reaction ofClwas investigated. The second order rateconstants (1.3  0.4) 108 and (1.1  0.4) 108 M1 s1 were determined for the reaction ofCl 0.4) 108 and (1.1  0.4) 108 M1 s1 were determined for the reaction ofCl2 with MT and DM, respectively. A reaction mechanism involving an initial chargetransfer from the sulfide groups of the insecticides to Clwith MT and DM, respectively. A reaction mechanism involving an initial chargetransfer from the sulfide groups of the insecticides to Cl2 is proposed and supported by theidentified transient intermediates and reaction products. The formation of chlorinatedbyproducts was determined. The unexpected consequences of an efficient Clis proposed and supported by theidentified transient intermediates and reaction products. The formation of chlorinatedbyproducts was determined. The unexpected consequences of an efficient Cl2 reactivitytowards MT and DM on the degradation capacity by Advanced Oxidation Proceduresapplied to polluted waters containing the insecticides and Cl anions is discussedreactivitytowards MT and DM on the degradation capacity by Advanced Oxidation Proceduresapplied to polluted waters containing the insecticides and Cl anions is discussed anions is discussed","palabras_clave":"Organophosphorous pesticides|Degradation|Chloride anion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1737,"idioma_id":5,"titulo":"La autonomía como proyecto: procesos de reflexión deliberada  en experiencias de autogestión","resumen":"Presentamos un análisis sobre el trabajo de organizaciones colectivas orientadas por el concepto de democracia como régimen de sentido (Castoriadis 1997).  Examinamos las reflexiones, debates e intercambios entre participantes de cinco proyectos auto-gestionados en la Argentina actual, y la relación entre dichos procesos y un espacio que reúne a representantes de esos mismos colectivos, denominado Mesa Colectiva de Trabajo. Destacamos algunos conceptos de la obra de Castoriadis desde la cual examinamos nuestra práctica, y a la vez, al examinarla, sostenemos la posibilidad de generar una conceptualización que se constituya en aporte a la institucionalización de la autogestión y a la autonomía como proyecto político. En particular, trabajamos con el concepto de reflexión deliberada y examinamos su efectiva posibilidad como práctica que otorgue espesor al proyecto de autonomía. ","palabras_clave":"AUTOGESTIÓN Y AUTONOMÍA COMO PROYECTO|REFLEXIÓN DELIBERADA|ETNOGRAFÍA Y SOCIOLINGÜÍSTICA APLICADAS|DIVERSIDAD SOCIOCULTURAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1738,"idioma_id":4,"titulo":"Phylogenetic analysis of bluetongue virus serotype 4 field isolates from Argentina","resumen":"Bluetongue (BT) is an insect-transmitted viral disease of ruminant species, which represents a major barrier to the international trade of animals and their products. Bluetongue virus (BTV) has a genome composed of ten linear segments of double-stranded RNA (dsRNA), which code for at least ten different viral proteins.  In South America, serological evidence for the presence of BTV has been found in Peru, Argentina, Brazil, Ecuador and Chile. Brazil and Argentina are the only South American countries where BTV has been isolated. In Brazil, only one BTV isolate, serotype 12, has been reported, whereas in Argentina five BTV serotype 4 isolates have been obtained from cattle without clinical signs. Three of these five isolates were isolated during 1999-2001, whereas two of them were obtained as part of the present work.  This study describes sequence comparisons and phylogenetic analyses of segments 2, 3, 6, 7 and 10 of the first Argentinean field isolates of BTV. The analysis of segments 2 and 6 resulted in a single cluster of Argentinean sequences into the serotype 4 clade. In addition, the Argentinean sequences grouped within the nucleotype A clade, along with reference strains. The analysis of segments 3, 7 and 10 showed that the Argentinean isolates grouped into the western topotype, indicating that the circulating virus had an African\/European origin. Phylogenetic analysis revealed that the Argentinean sequences present a South American genetic identity, suggesting an independent lineage evolution.","palabras_clave":"BTV|Argentina|Epidemiology|Characterization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1740,"idioma_id":4,"titulo":"Forest remnants contribute to parasitoid conservation: experimental evaluation of parasitism on a leafminer host","resumen":"Worldwide, intense forest fragmentation has  resulted in mosaic landscapes in which biodiversity and a  number of important ecological processes are threatened.  Insect parasitism is a vital component of herbivore population  regulation, hence the study of parasitism and parasitoid  richness in fragmented forests embedded in an  agricultural matrix is relevant from conservation and  management perspectives. Here, we investigated through  experimental &#64257;eld exposure of the leafminer Liriomyza  commelinae (Diptera: Agromyzidae) the effects of forest  remnant size and edge\/interior location on parasitism,  species richness and parasitoid community composition.  Two consecutive experiments were performed in which  pots with mined plants were placed in remnants of Chaco  Serrano forests in Central Argentina. Parasitism levels (on  average above 50 %) and number of parasitoids species (in  total, 20 species) were independent of forest remnant size.  However, higher parasitism and species richness were  found at the forest edge compared with the interior  although the differences in species richness failed to reach  statistical signi&#64257;cance. Parasitoid community composition  was not related to forest size whereas assemblages from  interior habitats showed closer similarity than those from  the edges. The results suggest forest remnants could play  an important role as reservoirs of parasitoids with potential  to control crop pests, a possibility heightened by the  positive edge effects which could facilitate the transfer of this valuable ecosystem service to the adjacent cultivated  land.","palabras_clave":"Parasitoid richness |Remnant size|Edge effect|Habitat fragmentation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1741,"idioma_id":4,"titulo":"Unique Dominant Negative Mutation in the N-Terminal Mitochondrial Targeting Sequence of StAR, Causing a Variant Form of Congenital Lipoid Adrenal Hyperplasia","resumen":"Context:Steroid acute regulatory (StAR) protein is a mitochondria-targeted protein that is part of the transduceosome complex crucial for transport of cholesterol to mitochondria. Recessive mutations cause classic and nonclassic congenital lipoid adrenal hyperplasia.Objective:The aim of this study was to report the clinical, hormonal, genetic, and functional data of a novel heterozygous mutation in the StAR gene found in a 46,XY patient with ambiguous genitalia and neonatal severe steroidogenic deficiency.Patient:Undetectable serum steroids with high ACTH and plasma renin activity but normal acute GnRH response were found in infancy. After gonadectomy (at 3 yr of age), serum LH and testosterone were undetectable, whereas FSH was normal but increased slowly afterward. Estrogen replacement therapy, started at 10.2 yr of age, suppressed gonadotropins (for 2 yr). However, after 1 month off estrogens, the patient showed castrated levels. At 11.9 yr old, after fludrocortisone withdrawal because of hypertension, plasma renin activity and aldosterone remained normal, suggesting mineralocorticoid recovery by a StAR-independent mechanism.Results:We found a de novo heterozygous IVS-2A&gt;G StAR mutation and the reported heterozygous p.G146A SF1 polymorphism with normal CYP11A1, FDXR, FDX1, VDAC1, and TSPO genes. The mutant StAR transcript lacked exon 2, resulting in the in-frame loss of amino acids 22 to 59 in the N-terminal mitochondrial targeting signal. In vitro, the mutant protein exhibited reduced StAR activity in a dominant-negative manner and almost no mitochondria localization.Conclusions:A misfolded p.G22_L59del StAR might interfere with wild-type StAR activity by blocking the transduceosome complex, causing an autosomal dominant form of StAR deficiency, explaining the clinical phenotype. We speculated that estrogen might have modulated mineralocorticoid function and pubertal maturation in a human natural model lacking endogenous steroid production.","palabras_clave":"46,XY DSD|StAR deficiency|Puberty onset"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1742,"idioma_id":4,"titulo":"Early Adaptive Immune Responses in the Respiratory Tract of Foot-and-Mouth Disease Virus-Infected Cattle","resumen":"Foot-and-mouth disease (FMD) is a highly contagious viral disease which affects both domestic and wild biungulate species. This acute disease, caused by the FMD virus (FMDV), usually includes an active replication phase in the respiratory tract for up to 72 h postinfection, followed by hematogenous dissemination and vesicular lesions at oral and foot epithelia. The role of the early local adaptive immunity of the host in the outcome of the infection is not well understood. Here we report the kinetics of appearance of FMDV-specific antibody-secreting cells (ASC) in lymphoid organs along the respiratory tract and the spleen in cattle infected by aerosol exposure. While no responses were observed for up to 3 days postinfection (dpi), all animals developed FMDV-ASC in all the lymphoid organs studied at 4 dpi. Tracheobronchial lymph nodes were the most reactive organs at this time, and IgM was the predominant isotype, followed by IgG1. Numbers of FMDV-ASC were further augmented at 5 and 6 dpi, with an increasing prevalence in upper respiratory organs. Systemic antibody responses were slightly delayed compared with the local reaction. Also, IgM was the dominant isotype in serum at 5 dpi, coinciding with a sharp decrease of viral RNA detection in peripheral blood. These results indicate that following aerogenous administration, cattle develop a rapid and vigorous genuine local antibody response throughout the respiratory tract. Time course and isotype profiles indicate the presence of an efficient T cell-independent antibody response which drives the IgM-mediated virus clearance in cattle infected by FMDV aerosol exposure.","palabras_clave":"FMDV|Innmune Response|ACS|Cattle"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1743,"idioma_id":4,"titulo":"Synthesis and characterization of conducting polypyrrole\/SBA-3 and polypyrrole\/Na-AlSBA-3 composites","resumen":"Si-SBA-3 and Na-AlSBA-3 materials were synthesized for application in the preparation ofcomposites. Silica mesoporous materials were obtained following the sol-gel method and postsynthesis alumination. Pyrrole-saturated hosts were prepared by adsorption of pyrrole into themesoporous materials. The adsorption\/desorption of pyrrole was studied by FTIR. Molecules ofpyrrole would be adsorbed through aromatic ring to the host. The polymerization technique wasperformed by oxidative way using different oxidizing agents, ammonium persulfate and ferricchloride, after pyrrole adsorption on both hosts. TG, FTIR, BET, XRD, SEM and TEM were used to characterize the resulting composites. These studies show that polypyrrole is generated inside the channel of the hosts; conductivity studies show that the composites exhibit conductivities at room temperature and in the range of 1.10-7 and 1.10-6 S.cm-1 depending on the host and theoxidizing agents.             Your article details                                                  Article:            Synthesis and characterization of conducting Polypyrrole\/SBA-3 and Polypyrrole\/Na-AlSBA-3 Composites                        Corresponding author:            Prof Oscar A. Anunziata                                                              Journal:            Materials Research Bulletin                        Our reference:            MRB6246                        PII:            S0025-5408(12)00865-3                        DOI:            10.1016\/j.materresbull.2012.11.030  ","palabras_clave":"A. composites|A. nanostructures|A. polymers| C. infrared spectroscopy|C. X-ray diffraction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1744,"idioma_id":4,"titulo":"Experimental determination and thermodynamic modeling of phase equilibrium and protein partitioning in aqueous two-phase systems containing biodegradable salts","resumen":"Phase diagrams of sustainable aqueous two-phase systems (ATPSs) formed by polyethyleneglycols (PEGs) of different average molar masses (4000, 6000, and 8000) and sodium succinate are reported in this work.  Partition coefficients (Kps) of seven model proteins: bovine serum albumin, catalase, beta-lactoglobulin,alpha-amylase, lysozyme, pepsin, urease and trypsin were experimentally determined in these systems and in ATPSs formed by the former PEGs and other biodegradable sodium salts: citrate and tartrate. An extension of Pitzer model comprising long and short-range term contributions to the excess Gibbs free energy was used to describe the (liquid + liquid) equilibrium. Comparison between experimental and calculated tie line data showed mean deviations always lower than 3%, thus indicating a good correlation. The partition coefficients were modeled by using the same thermodynamic approach. Predicted and experimental partition coefficients correlated quite successfully. Mean deviations were found to be lower than the experimental uncertainty for most of the assayed proteins.","palabras_clave":"enzymes| thermodynamic modeling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1745,"idioma_id":4,"titulo":"Covalent grafting of carbon nanotubes to PLA in order to improve compatibility","resumen":"An excellent methodology for the synthesis of nanocomposite materials using a biodegradable polymer as matrix (polylactic acid, PLA) and functionalized by Fenton reaction carbon nanotubes (fMWCNTs) as reinforcement was developed. PLA was modified with benzoyl chloride and both modified materials were bounded covalently by esterification reaction. Infrared spectroscopy (FTIR) and thermogravimetry (TGA) studies were performed to verify the synthesis of the composites obtained. Films based on modified PLA reinforced with fMWCNTs (PLAmfMWCNTs) were conformed observing excellent dispersion of the filler in the PLA matrix. Finally it was shown that the addition of fMWCNTs improves Young?s modulus and strength without losing deformation. Also it was observed that the good stability of the film let us to process it until 300 ºC. Taking into account all these results, the new biodegradable nanocomposite material developed could be very promising to be used in packaging and biomedical industries as a replacement of the synthetic materials.","palabras_clave":"A. Polymer-matrix composites (PMCs)| B. Physical properties|D. Mechanical testing|E. Casting"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1748,"idioma_id":5,"titulo":"Prácticas empíricas y medicina académica en Argentina. Aproximaciones para un análisis cuanticualitativo del Primer Censo Nacional (1869)","resumen":"Este trabajo analiza la distribución de los sujetos especializados dedicados al cuidado de la salud en el territorio argentino según el Primer Censo Nacional (1869). Se presentan aproximaciones estadísticas y recursos gráficos que contribuyen a mostrar las lógicas de la presencia absoluta y relativa de los diplomados y los practicantes empíricos considerados. A partir de la articulación entre datos del dispositivo censal y aportes bibliográficos especializados se evidencian ciertas variables vinculadas a la presencia estatal, al desarrollo socioeconómico diferencial de las regionesy los clivajes rural-urbano en la larga primera mitad del siglo XIX.","palabras_clave":"Argentina|medicos|medicina tradicional|censo de población"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1749,"idioma_id":4,"titulo":"Isolation and characterization of atrazine-degrading Arthrobacter sp. strains from Argentine agricultural soils","resumen":"Three bacterial strains capable of degrading atrazine  were isolated from Manfredi soils (Argentine) using  enrichment culture techniques. These soils were used to  grow corn and were treated with atrazine for weed control  during 3 years. The strains were nonmotile Gram-positive  bacilli which formed cleared zones on atrazine solid medium,  and the 16S rDNA sequences indicated that they were  Arthrobacter sp. strains. The atrazine-degrading activity of  the isolates was characterized by the ability to grow with  atrazine as the sole nitrogen source, the concomitant herbicide  disappearance, and the chloride release. The atrazinedegrader  strain Pseudomonas sp. ADP was used for comparative  purposes. According to the results, all of the isolates  used atrazine as sole source of nitrogen, and sucrose  and sodium citrate as the carbon sources for growth. HPLC  analyses confirmed herbicide clearance. PCR analysis  revealed the presence of the atrazine catabolic genes trzN,  atzB, and atzC. The results of this work lead to a better  understanding of microbial degradation activity in order to  consider the potential application of the isolated strains in  bioremediation of atrazine-polluted agricultural soils in  Argentina.","palabras_clave":"Atrazine-degrading bacteria|Agricultural soils|Enrichment techniques|Arthrobacter sp."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1750,"idioma_id":4,"titulo":"Seabird by-catch in the Argentinean demersal longline fishery, 2001 ? 2010","resumen":"Seabird mortality associated with fisheries is one of the major threats leading to population decreases of certain species, particularly albatrosses and petrels. The present study was conducted to (1)analyze seabird bycatch in the Argentinean demersal longline fishery during the decade 2001 to 2010, (2) provide a baseline of the levels of incidental mortality prior to the implementation of the National Planof Action&#8722;Seabirds, and (3) characterize in space and time the occurrence and intensity of seabird mortality. Fishing effort decreased from some 30 million to 5 million hooks set per year, and the overall bycatch rate for the whole period was 0.033 (0.019 SE) birds per 1000 hooks. The estimated total mortality for the 10 yr period was 7470 ± 2449 seabirds, the majority being black-browed albatrosses and white-chinned petrels. Seabird mortalities decreased by 1 order of magnitude towards the end of the decade, not due to lower bycatch rates but to a drop in the number ofhooks set per year. The progress achieved so far in Argentina is important, but if seabird bycatch is to be reduced to negligible levels,  it is imperative that the National Plan of Action&#8722;Seabirds is effectivelyimplemented and that the longline fishery comply with the conservation measure calling for the use of mitigation methods that came into effect in 2010. Other management-related actions, such as the increase of capacities within the National Observer Program and the refinement of seabird sampling protocols, will have an effect not only in the longline but also in the large trawl fishery, where seabird bycatch has also been documented.","palabras_clave":"seabird bycatch|Argentina|demersal longline"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1752,"idioma_id":4,"titulo":"A new model for dura mater healing: Human dural fibroblast culture","resumen":"Objective: Dura mater healing is crucial to prevent cerebrospinal fluid (CSF) leaks after neurosurgical  procedures. Biological mechanisms leading to dural closure are only partially understood and have been  studied in animals exclusively. We studied an in vitro model of dural closure which uses human cells.  Materials and methods: We used human dura intended for disposal after surgery. Explant primary cultures  were performed. Cells were characterized through common staining and immunohistochemistry. A cell growth  curve was elaborated and the effect of dexamethasone on cell count was assessed. SpongostanH, oxidized  regenerated cellulose and autologous plastic materials were also evaluated for their effect on cellular growth.  Results: All specimens showed growth in fusiform cells, which project pseudopods and fuse into spindles.  Cells showed desmin and vimentin positivity, and were negative for all the other stains, behaving  phenotypically like fibroblasts. No collagen base was necessary for cell growth. Dexamethasone  decreased cell count in the primary culture as well as in the explant, and reduced the cell proliferation  marker Ki-67. SpongostanH was successfully used as a graft, and fibroblast cultures were additionally  developed with muscle, pericranium, galea, and fascia. Oxidized cellulose induced cell death by lowering  the pH of the solution.  Discussion: According to the findings, unlike mini-pigs and rabbits, in humans, dural fibroblast sensitivity to  collagen seems to be lower. Dexamethasone inhibits fibroblast invasion, which is the biological base of  wound dehiscence in cranial surgery. Although Spongostan is useful, SurgicelH can lower the media pH,  thereby inhibiting cellular growth.","palabras_clave":"Cerebrospinal fluid leak|Dexamethasone|Dura mater|Fibroblast"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1753,"idioma_id":5,"titulo":"Continuidades y rupturas en las relaciones laborales de Argentina tras la crisis del neoliberalismo","resumen":"Durante la  década del 90 se han desarrollado profundas transformaciones en las relaciones laborales que han tendido a la flexibilización de las condiciones de trabajo, cuya base fueron las políticas económicas del neo liberalismo. A partir de 2003, se desarrollan una serie de transformaciones en el mercado de trabajo, en el régimen de acumulación y en el rol del Estado que  estarían trayendo cambios en los procesos de  flexibilización. En este marco, el objetivo del presente artículo es establecer los cambios y continuidades en las relaciones laborales en torno a los procesos de flexibilización laboral en argentina entre los periodos 1990-2002 y 2003-2011. Para el estudio comparativo, se analizan los procesos desarrollados en el nivel ?Macro?; y por medio de los contenidos de los Convenios Colectivos de Trabajo surgidos de la negociación colectiva en el sector automotriz y la distribución de energía eléctrica, aquellos vinculados al nivel ?Micro?","palabras_clave":"RELACIONES LABORALES|FLEXIBILIZACION DEL TRABAJO|NEGOCIACION COLECTIVA|GESTION DE LA FUERZA DE TRABAJO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1754,"idioma_id":4,"titulo":"The ekphrastic History of Rome: complementarity of geographical description and Aeneas?s shield in Book 8 of the Aeneid","resumen":"Book 8 of the Aeneid offers a broad account of Roman history from the protohistoric origins of Janus and Saturnus to the battle of Actium. The historical narrative develops over two long descriptive passages: one related to Evander and Aenea´s walk around Pallanteum and a second passage that is the description of Vulcan´s shield. The present author´s hypothesis is then framed with the premise that these passages are both ekphrasis that can be read and interpreted as complements. This approach allows us to understand the Virgilian view of history as a series of foundations based on the development of Romanurban geography, from meaningful natural geography, in association with chronological accounts of important leaders and their actions. Additionally, both passages are woven around the theme of order and complementarity: a geographical order and a chronological one. Both representations depend on each other to express their full meaning; that is, the consideration of urban geography as a reservoir of memory and Aeneas?s shield as organized narrative history.","palabras_clave":"discurso político|diversidad étnica|eneida de Virgilio|discurso histórico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1755,"idioma_id":4,"titulo":"ECOLOGY OF THAMNODYNASTES HYPOCONIA IN SUBTROPICAL- TEMPERATE SOUTH AMERICA","resumen":"The ecology of the genus&nbsp;Thamnodynastes&nbsp;has received little study, and problems with its taxonomy have generated imprecise and incorrect data. We analyzed the reproductive biology, sexual dimorphism, feeding ecology, habitat use, and seasonal activity of&nbsp;Thamnodynastes hypoconia&nbsp;in its subtropical?temperate area of distribution. We discuss its main ecological traits in light of the competition and predation, and the deep-history hypotheses. Males and females attained sexual maturity at different body sizes, with females achieving the largest sizes. In this species, the males and females had no difference in the body size, and males had more ventral scales than did the females. The females' reproductive cycle was seasonal and not annual, with parturition occurring in summer, whereas the cycle of the males was continuous.Thamnodynastes hypoconia&nbsp;feeds mainly on amphibians (97%) and occasionally on lizards (3%). As in otherThamnodynastes&nbsp;snakes, hylid frogs were the most common type of prey consumed (34%).&nbsp;Thamnodynastes hypoconia&nbsp;is primarily a twilight?nocturnal species that inhabits wetlands (large rivers and their floodplains), where its prey is abundant. Its activity is seasonal, with a high number of individuals encountered during the warm months. The similarity between the natural history traits of&nbsp;T. hypoconia&nbsp;(anurophagy, seasonal reproductive cycle, aquatic and nocturnal habits) and other species of the genus suggests there is phylogenetic conservatism, mainly of its ecomorphological traits, which is a pattern commonly reported for Dipsadidae snakes.             ","palabras_clave":"COMPETITION-PREDATION HYPOTHESIS|DEEP HISTORY HYPOTHESIS| DIET|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1756,"idioma_id":4,"titulo":"Monitoring oriental fruit moth (Lepidoptera: Tortricidae) with  sticky traps baited with terpinyl acetate and sex pheromone.","resumen":"AbstractStudies in Argentina and Chile during 2010?2011 evaluated a new trap (Ajar) for monitoring the oriental fruit moth, Grapholita molesta (Busck). The Ajar trap was delta-shaped with a jar filled with a terpinyl acetate plus brown sugar bait attached to the bottom centre of the trap. The screened lid of the jar was inserted inside the trap, and moths were caught on a sticky insert surrounding the lid. The Ajar trap was evaluated with and without the addition of a sex pheromone lure and compared with delta traps left unbaited or baited with a sex pheromone lure and a bucket trap filled with the same liquid bait. Studies were conducted in a sex pheromone-treated orchard in Argentina and an untreated orchard in Chile. In Chile, the Ajar trap without the sex pheromone lure caught significantly fewer males, females and total moths than the bucket trap, and fewer males and more females than the sex pheromone-baited delta trap. Total moth catch did not differ between the Ajar trap without a sex pheromone lure and the sex pheromone-baited trap. Adding a sex pheromone lure to the Ajar trap significantly increased total moth catches to levels not different from those in the bucket trap. However, the Ajar trap with the sex pheromone lure caught significantly more males and fewer females than the bucket trap. In Argentina, the Ajar trap with or without the addition of a sex pheromone lure caught similar numbers of both sexes and total moths as the bucket trap. The sex pheromone-baited delta trap caught <4% of the number of moths as these three traps. The bucket trap in both studies caught significantly more non-targets than the delta and Ajar traps. Moth catches in the Ajar trap declined significantly after 2?3 weeks when the bait was not replaced.","palabras_clave":"MATING DISRUPTION|NECTARINES|PEACHES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1757,"idioma_id":4,"titulo":"Use of marine space by Black-browed albatrosses during the non-breeding season in the Southwest Atlantic Ocean","resumen":"    Marine birds, like albatrosses and large  petrels, have shown a profound deterioration of their conservation statuses in  recent years. The Black-browed albatross is the most abundant and threatened  albatross species in the Southwest Atlantic  continental shelf. Declines in their breeding population have been largely attributed  to the impact of incidental mortality in fisheries. Data on the at-sea  distribution of breeding birds exists for the South   Atlantic, but scarce information is available during their  wintering period. Here, we investigate the  at-sea distribution of these species during the non-breeding season. Eleven  adults were tracked by means of satellite telemetry (PTTs) during 2011 and  2012.&nbsp; Distribution of Black-browed  albatross was mostly restricted to waters within the continental shelf of Argentina, Uruguay  and southern Brazil.  Two important marine areas, comprising ca. 90% of the core area (50%  utilization distribution) were identified. One was located from the mouth of Rio de la Plata  and waters to the East and another in El Rincón estuary and waters to the  South. Tracked  birds were distributed over nine oceanographic regimes defined for the Southwest Atlantic continental shelf. Adult birds spent between 5-34% of their time at sea in marine fronts of high productivity such as Rio de la Plata, Patos, Shelfbreak and Mixed front. The identified core areas for the species in the Southwest Atlantic Ocean should be considered of high priority at the time of implementing conservation measures to mitigate incidental mortality in fisheries among other threats seabirds might be facing. ","palabras_clave":"marine birds|habitat use"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1758,"idioma_id":5,"titulo":"Las relaciones capital - trabajo en el sector siderúrgico. Expresión de una nueva legalidad industrial?","resumen":"Este artículo focaliza las continuidades y rupturas que presenta la relación capital  - trabajo en un sector particular de la estructura industrial: la industria siderúrgica. Metodológicamente, el desarrollo se realiza a través de un estudio de caso situado en una empresa de origen estatal,  privatizada en 1992. La hipótesis que  guía el análisis indica que, al calor de los procesos de reestructuración productiva, tuvo lugar la emergencia de una legalidad industrial (Gramsci: 1981) cuya novedad consistiría en la transformación de los ?compromisos? existentes entre empresarios y sindicatos en lo que hace a las formas de uso y gestión de la fuerza de trabajo. Para mostrar este desarrollo, se describirá el despliegue de las relaciones sindicato ? empresa a través de tres núcleos centrales en las políticas de uso y gestión de la fuerza de trabajo: las transformaciones en las tareas y procesos productivos, la composición salarial y la conformación del colectivo de trabajo a través de las políticas de tercerización y subcontratación. A través de esta aproximación, se establecerán elementos distintivos de la legalidad industrial contemporánea y su vinculación las caracterizaciones de la situación contemporánea de la clase trabajadora argentina.","palabras_clave":"INDUSTRIA SIDERÚRGICA|LEGALIDAD INDUSTRIAL|ESTRATEGIAS EMPRESARIAS|ESTRATEGIAS SINDICALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1759,"idioma_id":5,"titulo":"Interrogando al sentido común desde las relaciones de hegemonía. Aproximación antropológica a los procesos de estigmatización de trabajadores industriales","resumen":"En este artículo se analizan elementos constitutivos del sentido común de diversos actores del mundo fabril y sindical, que tienen como centro a los migrantes rurales. Dichos elementos fueron identificados en el transcurso de investigaciones situadas en empresas del sector siderúrgico y del sector frigorífico. Se sostiene que los elementos identificados son producto de la apropiación y resignificación de determinados saberes académicos, que en la dinámica productiva se vuelven parte de un proceso de estigmatización de sectores de trabajadores. Se problematiza la articulación entre las construcciones ideológicas de los sujetos y las explicaciones provenientes de los ?saberes académicos? que analizan la dinámica de la clase obrera argentina. Para concluir se propone un abordaje centrado en el proceso y las condiciones de trabajo.","palabras_clave":"TRABAJADORES INDUSTRIALES|PROCESO DE ESTIGMATIZACIÓN|RELACIONES DE HEGEMONIA\/SUBALTERNIDAD|SABERES ACADEMICOS|PROCESO DE TRABAJO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1760,"idioma_id":10,"titulo":"Recentes avanços no tratamento da doença de Chagas","resumen":"Descoberta há cem anos, a doença de Chagas afeta a mais de quinze milhões de pessoas em toda a América Latina e, ainda hoje, não há tratamento eficaz. O fármaco benznidazol, utilizado como única opção de tratamento no Brasil, é ineficaz na fase crônica da doença. Problemas relacionados à biodisponibilidade do medicamento comercial limitam sua eficácia, principalmente na fase crônica, quando os parasitos estão confinados em tecidos profundos e em lenta replicação. Nesse contexto, pesquisas lideradas por grupos brasileiros e argentinos vêm sendo conduzidas com o objetivo de desenvolver formulações de benznidazol mais eficientes. Diversas formas farmacêuticas sólidas e líquidas foram propostas nos últimos anos com resultados pré-clínicos promissores, sendo descritas melhorias acentuadas nas características farmacocinéticas desse fármaco. Espera-se que as formas inovadoras apresentadas possam ser avaliadas em ensaios clínicos e incorporadas à produção industrial em breve.","palabras_clave":"DOENCA DE CHAGAS|BENZNIDAZOL|TRATRAMENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1761,"idioma_id":4,"titulo":"Allometric scaling of dry weight and leaf area for Spartina densiflora and Spartina alterniflora in two south-west Atlantic saltmarshes","resumen":"Southwest Atlantic saltmarshes are characterized by the presence of Spartina alterniflora in the lower intertidal zones and Spartina densiflora in the middle to high tidal elevations. Because of its dominance and productivity and its central role in carbon and energy fluxes, Spartina spp. biomass and primary production have been extensively studied by different techniques. Since nondestructive techniques require relationships between tiller biomass and morphometric parameters, in this work we established allometric relations among biomass, leaf area, and size, in populations of S. densiflora and S. alterniflora from Mar Chiquita and Bah &#769;a Blanca, Argentina. We collected 743   standing tillers of S. densiflora and 663 of S. alterniflora from different dates, conditions (green, flowered, and dead), and sources (high and low marsh). We obtained strong correlations between all the morphometric parameters. Leaf area and leaf length were strongly related (R2 1&#8260;4 0.84 for S. densiflora and 0.91 for S. alterniflora). Leaf area per tiller and tiller biomass strongly regressed on tiller height (R2 1&#8260;4 0.97 and 0.91 for S. densiflora and 0.88 and 0.90 for S. alterniflora, respectively) thereby facilitating estimations of these parameters. The predictive power of the biomass vs. tiller height equations was satisfactory when applied for different data types (date, condition, and source), suggesting that the models can be widely used for estimating the biomass of a tiller from its length. Moreover, the predictive power of the equations was high even for standing dead tillers, allowing us to use the same equation along the tiller?s span life and facilitating detritus production estimations. The allometric relations established in this study may be used to estimate Spartina biomass and leaf area at the study sites, with strong implications in the monitoring and assessment of saltmarshes.","palabras_clave":"ALLOMETRY|BIOMASS ESTIMATION|SPARTINA SPP.|TILLER LENGTH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1762,"idioma_id":5,"titulo":"Valores, intereses, liberación","resumen":"Se constata en las discusiones éticas en general y bioéticas en particular el uso de términos como 'valores' e 'intereses'. Se discute a menudo sobre su sentido, su admisibilidad en las discusiones en un mundo plural, y sobre la posibilidad de garantizar la legitimidad y validez de las afirmaciones morales. Esta conferencia aborda, en primera instancia, la cuestión de los intereses como el 'para quién' se ha hecho bioética. Esto implica ante todo un análisis histórico crítico del uso del término, particularmente en Latinoamérica. En un segundo lugar, el mismo método se aplica al término 'interés', y se estudia el vínculo entre interés y afirmaciones científicas y axiológicas. Finalmente se argumenta que la situacionalidad hermenéutica de Latinoamérica y el interés por exponer la palabra y valores de los grupos invisibilizados conlleva tomar como orientación heurística la noción de liberación. (Revista indexada&nbsp;en Clase, Filos&nbsp;y Latindex Catálogo crit. 20 y 21)&nbsp; ","palabras_clave":"ETICA|VALORES|INTERESES|LIBERACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1763,"idioma_id":4,"titulo":"The giant African snail, Achatina fulica (Gastropoda: Achatinidae): using bioclimatic models to identify South American areas susceptible to invasion","resumen":"The best way to reduce problems related to invasive species is by preventing introductions into potentially susceptible areas. The purpose of this study was to create distribution models for the invasive gastropod Achatina fulica Bowdich, 1822 in South America in order to evaluate its potential geographic distribution and identify areas at potential risk. This mollusc, considered one of the 100 world´s worst invasive alien species, is the focus of intense concern due to its impact on agriculture, human health, and native fauna. We tested two commonly used ecological niche modeling methods: Genetic Algorithm for Rule-Set Prediction (GARP) and Maximum Entropy (MaxEnt). Models were run with occurrence points obtained from several sources, including the scientific literature, international databases, governmental reports and newspapers, WorldClim bioclimatic variables, and altitude. Models were evaluated with the threshold-independent Receiver Operating Characteristic (ROC) and Area Under the Curve (AUC). Both models had consistent performances with similar areas predicted as susceptible, including areas already affected and new potentially susceptible areas in both tropical and temperate regions of South America.","palabras_clave":"LAND MOLLUSC|BIOINVASION|DISTRIBUTION|GARP|MAXENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1765,"idioma_id":5,"titulo":"La calidad de vida en el sudeste pampeano: Comparación de índices nacionales y regionales a principios del siglo XXI","resumen":"Este artículo se centra en la comparación de los resultados del Índice de Calidad de Vida (ICVN) propuesto por Velázquez (2008) a escala nacional con el propuesto por Mikkelsen (2011), quien ha elaborado un índice de calidad de vida regional (ICVR). Ambos índices han sido procesados a partir del uso de Sistemas de Información Geográfica y cuentan con la potencialidad de poner de manifiesto patrones generales de localización de los fenómenos socioterritoriales.","palabras_clave":"Calidad de vida|Indices|Sudeste pampeano|Region"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1767,"idioma_id":4,"titulo":"The potential of audiomagnetotellurics in the study of geothermal fields: A case study from the northern segment of the La Candelaria Range, northwestern Argentina","resumen":"Despite its reduced penetration depth, audiomagnetotelluric (AMT) studies can be used to determine a broad range of features related to little studied geothermal fields. This technique requires a stepwise  Interpretation of results taking into consideration diverse information (e.g. topographic, hydrological, geological and\/or structural data) to constrain the characteristics of the study area. In this work, an AMT study was performed at the hot springs in the northern segment of the La Candelaria Range in order to characterize the area at depth. Geometric aspects of the shallow subsurface were determined based on the  dimensional and distortion analysis of the impedance tensors. Also, the correlation between structural features and regional strikes allowed us to define two geoelectric domains, useful to determine the controls on fluid circulation. The subsurface resistivity distribution was determined through 1D and 2D models. The patterns of the 1D models were compared with the morpho-structure of the range. Shallow and deep conductive zones were defined and a possible shallow geothermal system scheme proposed. A strong correlation was found between the AMT results and the geological framework of the region, showing the relevance of using AMT in geothermal  areas during the early stages of subsurface prospecting.","palabras_clave":"AUDIOMAGENETOTELLURIC|GEOTERMAL FIELD|GEOLECTRIC STRIKE|LA CANDELARIA RANGE NW"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1768,"idioma_id":4,"titulo":"A contextual approach of Functional Analysis: cases from Patagonia Argentina.","resumen":"In this paper we present our position on the analytical dimension and application of functional analysis of lithic remains. We understand this methodology, not only as a particularized analytic approximation   of knowing how a tool was used, but as a methodology which is inserted in a bigger context, aiming to gain knowledge about the systems of technological organization of human societies.   Each object can be seen as a world in which two kinds of actions are reflected: 'how it was done' and 'what was it done for'. Both actions can be studied through different analytical methodologies.   Functional analysis must be understood and developed as one of the approaches which should be integrated in the study of the lithic assemblages, including technomorphological studies, distributional   research and experimentations. This way, functional analysis is no longer a method only limited to determine the function of stone tools, but it projects itself towards wider interpretations regarding the technological systems of a society.   In order to exemplify our position, we have selected three case studies from the Argentine Patagonia in which we have put into practice this theoretical view. Two of them refer to the initial settling of people   during the Final Pleistocene (sites Cerro Tres Tetas 1 and Casa del Minero 1) and one is linked to a middle Holocene context (site Cueva 13 of Los Toldos).","palabras_clave":"hunter gatherers|functional analysis|technological organization|new approach"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1769,"idioma_id":4,"titulo":"Competition between surface relaxation and ballistic deposition models in scale free networks","resumen":"In this paper we study the scaling behavior of the fluctuations in thesteady state WSwith the system size N for asurface growth process given by the competition between the surfacerelaxation (SRM) and the ballistic deposition (BD) models on degreeuncorrelated scale-free (SF)networks, characterized by a degree distribution P(k)&#8764; k&#8722;&#955;, where k is the degree of a node.It is known that the fluctuations of the SRM model above the criticaldimension (dc =2) scalelogarithmically with N onEuclidean lattices. However, Pastore y Piontti et al. (Phys. Rev. E, 76(2007) 046117) found that the fluctuations of the SRM model in SFnetworks scale logarithmicallywith Nfor &#955;&lt;3 and as a constant for &#955; _ 3. In this letter we found that for a pure ballisticdeposition model on SF networks WS scales as a power law with an exponent that depends on &#955;.On the other hand when both processes are in competition, we find thatthere is a continuouscrossover between a SRM behavior and a power law behavior due to the BDmodel that dependson the occurrence probability of each process and the system size.Interestingly, we find thata relaxation process contaminated by any small contribution of ballisticdeposition will behave,for increasing system sizes, as a pure ballistic one. Our findings couldbe relevant when surfacerelaxationmechanisms are used to synchronize processes that evolve on top of complexnetworks.","palabras_clave":"Redes Complejas|Interfaces"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1770,"idioma_id":4,"titulo":"Search for extra dimensions in diphoton events using proton-proton collisions recorded at &#8730;s =7 TeV with the ATLAS detector at the LHC","resumen":"The large difference between the Planck scale and the electroweak scale, known as the hierarchy problem, is addressed in certain models through the postulate of extra spatial dimensions. A search for evidence of extra spatial dimensions in the diphoton channel has been performed using the full set of proton\u2013proton collisions at  recorded in 2011 with the ATLAS detector at the CERN Large Hadron Collider. This dataset corresponds to an integrated luminosity of 4.9 fb&#8722;1. The diphoton invariant mass spectrum is observed to be in good agreement with the Standard Model expectation. In the context of the model proposed by Arkani\u2013Hamed, Dimopoulos and Dvali, 95% confidence level lower limits of between 2.52 and 3.92 TeV are set on the ultraviolet cutoff scale MS depending on the number of extra dimensions and the theoretical formalism used. In the context of the Randall\u2013Sundrum model, a lower limit of 2.06 (1.00) TeV at 95% confidence level is set on the mass of the lightest graviton for couplings of k\/\\bar{Mpl}=0.1(0.01). Combining with the ATLAS dilepton searches based on the 2011 data, the 95% confidence level lower limit on the Randall\u2013Sundrum graviton mass is further tightened to 2.23 (1.03) TeV for k\/\\bar{Mpl}=0.1(0.01).","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1772,"idioma_id":5,"titulo":"La activación de receptores activados por proliferadores peroxisomales (PPARs) como reguladora del metabolismo lipídico en la placenta de pacientes con diabetes.","resumen":"Dadas las alteraciones metabólicas inducidas por la diabetes materna y la capacidad de los receptores nucleares PPARs de regular el metabolismo lipídico se propuso como objetivo evaluar los niveles de lípidos y PPARs en la placenta de pacientes sanas y con diabetes tipo 2, y determinar si la activación de PPARs regula los niveles y peroxidación lipídica en dichos tejidos. Metodología: Las placentas fueron obtenidas luego del alumbramiento, se determinaron los niveles de lípidos mediante cromatografía, los niveles de PPARs mediante Western blot y la peroxidación lipídica mediante la cuantificación de TBARS. Resultados: Se evidenciaron mayores niveles de lípidos y menores niveles de PPARalfa y PPARgamma en placenta de pacientes diabéticas en relación al control (p 0,05). Agonistas de PPARalfa redujeron  la masa lipídica en la placenta de pacientes sanas y diabéticas, mientras que la activación de PPARgamma la redujo sólo en la placenta de pacientes sanas. Al activar PPARgamma aumenta la masa lipídica y la expresión de la enzima de síntesis de ácidos grasos FASN (p 0,05). La peroxidación lipídica, incrementada en placenta de pacientes diabéticas (p 0,001), se reguló negativamente al activar los tres isotipos de PPARs (p 0,05). Conclusión: Se identificaron en este estudio noveles funciones de PPARs en la placenta humana relevantes en la regulación del metabolismo lipídico y la lipoperoxidación. La diabetes tipo 2 induce a nivel placentario alteraciones en los niveles y función de PPARs vinculadas a las importantes anomalías en el metabolismo lipídico y un estado pro-oxidante inducidas por esta patología.","palabras_clave":"PPAR|diabetes materna|metabolismo lipídico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1773,"idioma_id":4,"titulo":"Use of Shell-shape to discrimate between Brachidontes rodriguezii and Brachidontes purpuratus species (Mytilidae) in the transition zone of their distributions (South-western Atlantic)","resumen":"    Mussels are important components of rocky shore assemblages throughout    the world. Several Mytilid species are found as multilayered beds in the    intertidal along the coasts of the South-western Atlantic. However, in    contrast to the North communities in the Pacific and Atlantic, those of the    Southwestern Atlantic are dominated by species of small size, locally    named mejillines. These mid-intertidal beds attached to consolidated    substrates are dominated by virtual monocultures of two small-sized    species of Brachidontes: B. rodriguezii (d?Orbigny, 1842) and B. (=    Perumytilus) purpuratus Lamarck, 1819, respectively distributed in the    warm and cold temperate sectors of the South-western Atlantic; both    coexisting in the transition zone between 40º and 44º S latitude.    Nevertheless, there has been some confusion about the separation of    Brachidontes rodriguezii and B. purpuratus, as well as about the    boundaries of their distribution ranges in the Southwestern Atlantic. Here,    on the basis of a morphogeometric analysis of shell morphology, we    describe a feasible way for the identification of both species.","palabras_clave":"BRACHIDONTES|GEOMETRIC MORPHOMETRICS|SHELL SHAPE MORPHOLOGY|TRANSITION ZONE DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1775,"idioma_id":4,"titulo":"Distribution pattern of trees in a hydrological gradient below the Paraná-Paraguay River confluence. American Journal of Plant Sciences.","resumen":"ABSTRACT  Riparian and riverine aquatic plant species have evolved within the context of flowing water habitats for which the flooding and droughts are the forcing factors that shape the community features, either through a positive or negative effect on the ecosystem?s function, according to the timing, frequency and magnitude of such events. In the Paraná floodplain landscape, topographic position is a crude indicator of the position along the complex gradient, but it also includes information about flood\/drought periods and trees? resilience to extreme hydrological phases. We present the occurrence of major tree species in riparian forests of the Paraná River on islands of different topographies in a section of the Paraná River downstream from the confluence with the Paraguay River. Our results suggest that each tree species had a preferred position in the topographic gradient, sites where the observed counts were more frequent. This trees species were more frequent between 2 and 8 m in the topographic position and were affected by 5 and 202 hydrosedimentologic pulses between 1949 and 1999. We suggest that knowledge of the distribution curves of the vegetation species present can help draw possible future scenarios of the river landscape. Future engineering works to alter the hydro- logical dynamics of Paraná should pay more attention to the distribution of riparian forests because they are indicators of changes at the landscape level and they are the support for the wildlife of the river.","palabras_clave":"Riverine Forests;  Fluvial Landscape|Paraná Floodplain; |Ecohydrology; |River Pulse;"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1776,"idioma_id":4,"titulo":"Energetic study of cardioplegic hearts under ischaemia\/ reperfusion and [Ca2+] changes in cardiomyocytes of guinea-pig: mitochondrial role","resumen":"Aim: To study the role of mitochondria in the recovery of guinea-pig hearts exposed to high-K+-cardioplegia (CPG) and ischemia\/reperfusion (I\/R) Methods: We measured contractility and heat release in perfused guinea-pig hearts and cytosolic and mitochondrial Ca2+ by epifluorescence and confocal microscopy in isolated cardiomyocytes loaded with Fluo-4 or Rhod-2. Results: In hearts, CPG increased the post-ischemic contractile recovery and this was potentiated by the mNCX blocker clonazepam and the mKATP opener diazoxide, which also prevented the fall in muscle economy. Moreover, CPG prevented the stunning induced by ouabain, which was reduced by clonazepam. In cardiomyocytes, CPG increased fluorescent signals of cytosolic and mitochondrial Ca2+, while addition of a mNCX blocker (CGP37157) increased cytosolic but reduced mitochondrial [Ca2+]. Ouabain in CPG increased cytosolic Ca2+ and resting heat, but addition of CGP37157 reduced them, as well as mitochondrial Ca2+. Conclusions: CPG, diazoxide and clonazepam improve post ischemic recovery respectively by increasing Ca2+ cycling, and by reducing the mitochondrial Ca2+ uptake either by uniporter or by mNCX. The mitochondria compete with the leaky sarcoplasmic reticulum (SR) as sink of Ca2+ in guinea-pig hearts, affecting the post ischemic contractility. CPG also prevented the ouabain-induced dysfunction by avoiding the Ca2+ overload. Ouabain reduced the synergism between CPG and clonazepam suggesting that [Na+]i and SR load influence the mNCX role.&nbsp; ","palabras_clave":"calcio|calorimetry|ischemia-reperfusion|mitochondria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1777,"idioma_id":5,"titulo":"TECNOLOGÍAS SOCIALES COMO UN EMERGENTE TERRITORIAL: APORTES PARA UN MODELO DE GESTIÓN DEL HÁBITAT POPULAR. Experiencia matriz para pilares de conexión eléctrica, Mar del Plata, Argentina.","resumen":"Este artículo se propone aportar a la discusión sobre las formas de gestión en el campo del hábitat popular. A partir de los supuestos teóricos de las denominadas tecnologías para la inclusión social, se analizará la experiencia del emprendimiento de producción de pilares de hormigón para la conexión de electricidad domiciliaria en el barrio Alto Camet de la ciudad de Mar del Plata. Las tecnologías para la inclusión social constituyen un concepto en construcción; un área que requiere investigaciones de base territorial concreta para profundizar en sus interrogantes. En este marco, interesa un doble eje de análisis. El primero, el artefacto; en este caso, una matriz de madera como respuesta a un problema y como resultado de un proceso complejo e interactivo de construcción social y técnica en el que intervienen sistemas tecnológicos, personas, instituciones, el Estado, empresas, organizaciones de la sociedad civil y territorios específi cos. El segundo, esta dinámica como base de innovaciones tecnológicas y productivas y de cambios sociopolíticos.","palabras_clave":"MODELOS DE GESTION|HABITAT POPULAR|TECNOLOGIAS SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1778,"idioma_id":4,"titulo":"Precipitation rather than temperature influenced the phylogeography of the endemic shrub Anarthrophyllum desideratum in the Patagonian steppe","resumen":"ABSTRACT   Aim  In order to assess the impact of precipitation changes during Pleistocene glaciations on plant species of the Patagonian steppe, a phylogeographical study of the endemic shrub Anarthrophyllum desideratum was performed. Location Southern Patagonia: Argentina and Chile.  Methods  Chloroplast intergenic spacers trnS?trnG and rpoB?trnC were sequenced for 264 individuals from 33 localities spanning the entire distribution of A. desideratum. Phylogenetic (statistical parsimony, maximum likelihood and Bayesian inference) and population genetic analyses (spatial analyses of molecular variance, mismatch distributions, neutrality tests and Bayesian skyline plot) were performed. Divergence time estimates using a calibrated molecular clock were also conducted. Niche modelling was used to reconstruct the palaeodistribution to validate phylogeographical patterns.  Results  Thirty haplotypes were identified that clustered into two main lineages, revealing a significant latitudinal phylogeographical break north and south of the Deseado River (c.47°S). Infra-specific diversification began in the late Miocene, with northern and southern lineages separating c. 3 Ma, after the eastern Patagonian lowlands started to become increasingly arid. Three areas of high molecular diversity were identified: one in southern and two in northern Patagonia where niche modelling indicates that the species may have survived during the Last Glacial Maximum. These putative refugia received more moisture than much of the steppe during glaciation-associated aridization. The south-western refugium is the more likely source for eastward range expansion during post-glacial humidification.  Main conclusions  Anarthrophyllum desideratum responded differently to historical processes north and south of the Deseado River. In the north this species survived in situ in fragmented populations, whereas in the south it survived in localized refugia that presumably avoided extreme aridization, and from which it expanded eastwards. For southern Patagonia, our results support a new historical scenario affected more by precipitation regimes than by temperature changes associated with glacial cycles. This hypothesis should be considered in future plant phylogeographical studies from the Patagonian steppe.  Keywords  Aridization, cold?warm hypothesis, ecological niche modelling, Fabaceae, historical water balance, in situ survival, plant phylogeography, Pleistocene glaciations, refugia, westerlies.","palabras_clave":"ARIDIZATION|COLD-WARM HYPOTHESIS|ECOLOGICAL NICHE MODELLING|FABACEAE|HISTORICAL WATER BALANCE|'IN SITU' SURVIVAL|PLEISTOCENE GLACIATIONS|REFUGIA|WESTERLIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1780,"idioma_id":4,"titulo":"A general Ritz algorithm for the static analysis of arbitrarily laminated composite plates using First Order Shear Deformation Theory","resumen":"This paper is concerned with the bending of laminated composite plates with arbitrary lay-up and general boundary conditions. The present analysis is based on the small deflection, first-order shear deformation theory of composite plates, which utilizes the Reissner-Mindlin plate theory. In solving the aforementioned plate problems, a general algorithm based on the Ritz method and the use of beam orthogonal polynomials as coordinate functions is derived. This general algorithm provides an analytical approximate solution that can be applied to the static analysis of moderately thick laminated composite plates with any lamination scheme and combination of edge conditions.  The convergence, accuracy and flexibility of the obtained general algorithm are shown by computing several numerical examples and comparing some of them with results given in the literature. Some results including general laminates and nonsymmetrical boundary conditions with free edges are also presented.","palabras_clave":"PLATE BENDING|GENERAL LAMINATED COMPOSITE PLATES|FIRST ORDER SHEAR DEFORMATION THEORY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1781,"idioma_id":4,"titulo":"Optimal Control Based Heuristic for Congestion Reduction in Traffic Networks","resumen":"The principal purpose of this work is to test the TUC strategy in a simple case using a micro-simulator designed ad hoc, previous to its real implementation. Using concepts of traffic engineering we describe a well known dynamic linear model of traffic flow in a urban traffic network that is controlled using the traffic-light times. This simplified model allows to obtain a Riccati feedback matrix and compute traffic-light times that will improve the congestion levels.  We present some numerical experiments made with the model on an academic example and we validated them with a microscopic simulator that we have created based on Car Following theory and discrete event models.","palabras_clave":"Optimal Control|LQ-Control|Urban traffic models"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1782,"idioma_id":5,"titulo":"La eficacia de la práctica analítica en el hospital público","resumen":"Este trabajo se desprende de la investigación UBACyT 2010-2012 ?PROYECTOS TERAPÉUTICOS BAJO LA CLÍNICA PSICOANALÍTICA EN EL HOSPITAL PÚBLICO?  - directora Inés Sotelo, codirector Guillermo Belaga.  Este proyecto trata sobre el psicoanálisis aplicado inscripto en el ámbito de la Salud Mental, donde la evaluación de la eficacia y la rapidez de las diferentes psicoterapias es insoslayable.   La eficacia analítica se observa en alcances que son singulares, y que no responden ni se reducen a un ideal de curación previo. Esto no implica, sin embargo, que no se produzcan también efectos terapéuticos susceptibles de evidenciarse.  De este modo, se subvirtieron algunos de los significantes del discurso del amo, tales como ?eficacia? y ?evaluación?, buscando dar cuenta de lo específico y diferencial de nuestra práctica psicoanalítica.","palabras_clave":"Psicoanálisis|Evaluación|Eficacia |Investigación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1783,"idioma_id":5,"titulo":"?MODIFICACIONES PRODUCIDAS POR LA EDAD EN EL FLUJO TRANSMITRAL EN EL PERRO?","resumen":"RESUMEN    Los autores estudiaron el efecto de la edad sobre el flujo transmitral en el perro. Se estudiaron por    medio de Doppler espectral pulsado 96 caninos cardiológicamente sanos los cuales fueron separados    en cinco grupos por edad (grupo 1, de 1 a 3 años [n=11]; grupo 2, de 4 a 6 años [n=22]; grupo    3, de 7 a 9 años [n=33]; grupo 4, de 10 a 12 años [n=15]; grupo 5, más de 13 años [n=16]). Los    resultados obtenidos indican que la edad influencia en forma significativa las características del flujo    transmitral. Los individuos de menos de 6 años de edad presentaron flujo transmitral normal mientras    que los mayores mostraron alteraciones. Para la velocidad pico de la onda E se observaron diferencias    significativas (p&lt;0,0001) entre los tres últimos grupos (3, 4 y 5) y los dos primeros (1 y 2). Lo mismo    ocurrió para el caso de la pendiente de desaceleración de la onda E (p&lt;0,0001) y la velocidad pico    de la onda A (p=0,0003). Respecto de la relación E\/A presentaron diferencias estadísticamente    significativas, los grupos 1 y 2 del grupo 3 y a su vez también del grupo 4 y 5 (p&lt;0,0001). No se    observaron diferencias significativas (p&gt;0,05) entre los cinco grupos para los parámetros Tiempo de    desaceleración de la onda E y Tiempo de relajación isovolúmico.      &nbsp;","palabras_clave":"Función diastólica|Canino|Edad|Flujo transmitral"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1785,"idioma_id":4,"titulo":"A Categorical Approach to Structuring and Promoting Z Specifications","resumen":"In this paper, we study a formalisation of specification structuring mechanisms used in Z. These mechanisms are traditionally understood as syntactic transformations. In contrast, we present a characterisation of Z structuring mechanisms which takes into account the semantic counterpart of their typical syntactic descriptions, based on category theory. Our formal foundation for Z employs well established abstract notions of logical systems. This setting has a degree of abstraction that enables us to understand what is the precise semantic relationship between schemas obtained from a schema operator and the schemas it is applied to, in particular with respect to property preservation.  Our formalisation is a powerful setting for capturing structuring mechanisms, even enabling us to formalise promotion. Also, its abstract nature provides the rigour and flexibility needed to characterise extensions of Z and related languages, in particular the heterogeneous ones.","palabras_clave":"System Specification|Software Engineering|Formal Notation|Category Theory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1786,"idioma_id":4,"titulo":"On controller-driven varying-sampling-rate stabilization via Lie-algebraic solvability","resumen":"Control systems involving shared communications networks are becoming  ubiquitous. The inclusion of a communications network within a feedback  loop imposes new control challenges. We consider a setting where a centralized controller\/scheduler is in charge of the control of several processes and also of administering access to the shared communications network. In this setting, the controller may perform on-line variations of the sampling rate of all processes in order to accommodate for new processes requiring access to the network and to maximize performance when processes finish operation. We refer to this setting as controller-driven varying-sampling-rate (VSR). We regard a continuous-time system sampled at varying rates as a discrete-time switched system (DTSS), and aim at devising sampling-rate dependent feedback to ensure stability irrespective of the way in which the sampling rate is varied. Our feedback design strategy is based on Lie-algebraic solvability. The current paper presents two main contributions: a) it demonstrates that control design based on Lie-algebraic solvability is much less restrictive when applied to the controller-driven VSR setting than when applied to DTSSs of arbitrary form, and b) we give sufficient conditions for the stabilizability of the VSR-DTSS by means of the Lie-algebraic-solvability condition. As opposed to previous results, these sufficient conditions do not impose a restriction on the number of subsystems of the DTSS.","palabras_clave":"varying sampling|stability|switched systems|solvable Lie algebras|simultaneous triangularization|networked control systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1787,"idioma_id":4,"titulo":"A Particle Consistent with the Higgs Boson Observed with the ATLAS Detector at the Large Hadron Collider","resumen":"Nearly 50 years ago, theoretical physicists proposed that a field permeates the universe and gives energy to the vacuum. This field was required to explain why some, but not all, fundamental particles have mass. Numerous precision measurements during recent decades have provided indirect support for the existence of this field, but one crucial prediction of this theory has remained unconfirmed despite 30 years of experimental searches: the existence of a massive particle, the standard model Higgs boson. The ATLAS experiment at the Large Hadron Collider at CERN has now observed the production of a new particle with a mass of 126 giga\u2013electron volts and decay signatures consistent with those expected for the Higgs particle. This result is strong support for the standard model of particle physics, including the presence of this vacuum field. The existence and properties of the newly discovered particle may also have consequences beyond the standard model itself.","palabras_clave":"HIGH ENERGY PHYCICS|HIGGS|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1788,"idioma_id":4,"titulo":"Search for new phenomena in events with three charged leptons at a center-of-mass energy of 7 TeV with the ATLAS detector","resumen":"A generic search for anomalous production of events with at least three charged leptons is presented. The search uses a pp-collision data sample at a center-of-mass energy of &#8730;s=7&#8201;&#8201;TeV corresponding to 4.6&#8201;&#8201;fb-1 of integrated luminosity collected in 2011 by the ATLAS detector at the CERN Large Hadron Collider. Events are required to contain at least two electrons or muons, while the third lepton may either be an additional electron or muon, or a hadronically decaying tau lepton. Events are categorized by the presence or absence of a reconstructed tau-lepton or Z-boson candidate decaying to leptons. No significant excess above backgrounds expected from Standard Model processes is observed. Results are presented as upper limits on event yields from non-Standard-Model processes producing at least three prompt, isolated leptons, given as functions of lower bounds on several kinematic variables. Fiducial efficiencies for model testing are also provided. The use of the results is illustrated by setting upper limits on the production of doubly charged Higgs bosons decaying to same-sign lepton pairs.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1789,"idioma_id":4,"titulo":"High cholesterol diet effects on ischemia-reperfusion injury of the heart.","resumen":"  Abstract  Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia\/reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, hypercholesterolemia which is one of the main ones. Therefore, the objective of this revision was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia\/reperfusion injury-associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority was carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins which apart from exerting a lipid-lowering effect, they exert pleiotropic effects providing cardioprotection against ischemia\/reperfusion injury. These controversial results regarding mechanisms of cardioprotection, vary according to: quality, composition andhigh-cholesterol diet time of administration as well as the different species used in each experiment. Thus, in order to compare the results, it is necessary to take all these variables into account since they can change the obtained results.","palabras_clave":"HYPERCHOLESTEROLEMIA|ISCHEMIA-REPERFUSION INJURY|VENTRICULAR FUNCTION|MYOCARDIAL INFARCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1790,"idioma_id":5,"titulo":"Personalización y escuela secundaria: dinámicas de escolarización en diferentes grupos sociales","resumen":"El artículo se basa en los resultados de dos investigaciones que dan cuenta de una serie de cambios en los modos de efectivizar la escolarización secundaria de los jóvenes provenientes de diferentes sectores sociales. En el mismo se presentan los procesos de personalización identificados en tanto estrategia para la escolarización en contextos signados por la desigualdad. El análisis aborda instituciones orientadas a la formación de élites que desarrollan el programa de Bachillerato Internacional, y un conjunto de escuelas que recibe a jóvenes, mayormente de sectores socioeconómicamente pobres, que han quedado fuera de la secundaria. Más allá de las profundas distancias y diferencias identificadas indaga las continuidades en torno a los procesos de personalización de las relaciones entre docentes y alumnos que serán el centro del análisis.  La revista está indizada en: e-revist@s; Gale Cengage Learning.","palabras_clave":"Escuela Secundaria|Personalización|Escuelas de Reingreso|Bachillerato Internacional"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1792,"idioma_id":5,"titulo":"ANÁLISIS DE LA FUTURA INTRUSION SALINA EN UN ACUÍFERO COSTERO COMO RESPUESTA AL CAMBIO CLIMÁTICO. PARTIDO DE LA COSTA, PROVINCIA DE BUENOS AIRES","resumen":"De acuerdo al cuarto informe del IPCC el aumento del nivel del mar sería uno de los efectos más importantes del cambio climático global y la intrusión salina en los acuíferos costeros representaría un impacto significativo en tal sentido. La metodología propuesta por Werner y Simmons (2009) siguiendo a Custodio (1987) fue utilizada para cuantificar el avance salino en el acuífero costero del Partido de La Costa, Buenos Aires, Argentina. El modelo de flujo constante, en donde la lente de agua dulce no disminuye el espesor pero se produce una elevación de los niveles, sugiere que la intrusión salina avanzará en 23, 33 y 38 metros dependiendo de los escenarios de recarga y considerando 1 metro de aumento del nivel del mar. Los resultados del modelo a carga hidráulica constante, el cual se basa en la reducción del espesor del acuífero con el aumento del nivel del mar, muestran una intrusión de la cuña salina mucho mayor, siendo 193, 199 y 211 metros para los parámetros utilizados. Si se cumple el modelo de flujo constante el acuífero no estaría muy afectado según los diferentes escenarios de variaciones de nivel del mar y consumo de agua. Si el modelo es a carga hidráulica constante, lo cual  sería más probable debido a la baja topografía de la zona, el avance de la intrusión salina mayor a 200 metros degradaría severamente el acuífero forzando a los tomadores de decisiones a una gestión más cuidadosa  del agua dulce para abastecimiento a los habitantes.","palabras_clave":"CLIMATE CHANGE|SALT WATER INTRUSION |COASTAL AQUIFER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1793,"idioma_id":4,"titulo":"Basal sauropodomorphs from the Ischigualasto Formation","resumen":"Basal sauropodomorphs from the Ischigualasto Formation include Eoraptor lunensis, Panphagia protos, and Chromogisaurus novasi. Few comparisons have been made between these taxa, because Eoraptor was only recently reassessed as a basal sauropodomorph and because Panphagia and Chromogisaurus were described nearly simultaneously. We describe in detail the fully prepared bones of the holotype of Chromogisaurus novasi, examine the evidence for its taxonomic distinction, and analyze the phylogenetic relationships among basal sauropodomorphs. Our results support Chromogisaurus novasi as a valid genus and species and provide weak phylogenetic evidence favoring a series of stem taxa at the base of Sauropodomorpha. The analysis positions Panphagia as the basal-most sauropodomorph, followed by Eoraptor, Pampadromaeus, and a clade that includes Chromogisaurus and Saturnalia.","palabras_clave":"DINOSAURIA|SAUROPODOMORPHA|ISCHIGUALASTO|TRIASSIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1794,"idioma_id":4,"titulo":"Getting a grip on tetrapod grasping: form, function, and evolution","resumen":"Humans have been credited with unparalleled capabilities for digital prehension grasping.However, grasping behaviour is widespread among tetrapods. The propensity to grasp, and theanatomical characteristics that underlie it, appear in all of the major groups of tetrapods with the possible exception of terrestrial turtles. Although some features are synapomorphic to the tetrapod clade, such as well-defined digits and digital musculature, other features, such as opposable digits and tendon configurations, appear to have evolved independently in many lineages. Here we examine the incidence, functional morphology, and evolution of grasping across four major tetrapod clades. Our review suggests that the ability to grasp with the manus and pes is considerably more widespread, and ecologically and evolutionarily important, than previously thought. The morphological bases and ecological factors that govern grasping abilities may differ among tetrapods, yet the selective forces shaping them are likely similar. We suggest that further investigation into grasping form and function within and among these clades may expose a greater role for grasping ability in the evolutionary success of many tetrapod lineages.Key words: grasping; grip force; biomechanics; tetrapods; lizards; amphibians; mammals; birds;digits; dexterity; manus; pes; feeding; locomotion; morphology","palabras_clave":"grasping|biomechanics|tetrapods|dexterity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1795,"idioma_id":4,"titulo":"SUPG and discontinuity-capturing methods for coupled fluid mechanics and electrochemical transport problems","resumen":"Electrophoresis is the motion of charged particles relative to the surrounding liquid under the influence of an external electric field. This electrochemical transport process is used in many scientific and technological areas to separate chemical species. Modeling and simulation of electrophoretic transport enables a better understanding of the physicochemical processes developed during the electrophoretic separations and the optimization of various parameters of the electrophoresis devices and their performance. Electrophoretic transport is a multiphysics and multiscale problem. Mass transport, fluid mechanics, electric problems, and their interactions have to be solved in domains with length scales ranging from nanometers to centimeters. We use a finite element method for the computations. Without proper numerical stabilization, computation of coupled fluid mechanics, electrophoretic transport, and electric problems would suffer from spurious oscillations that are related to the high values of the local Péclet and Reynolds numbers and the nonzero divergence of the migration field. To overcome these computational challenges, we propose a stabilized finite element method based on the Streamline-Upwind\/Petrov-Galerkin (SUPG) formulation and discontinuity-capturing techniques. To demonstrate the effectiveness of the stabilized formulation, we present test computations with 1D, 2D, and 3D electrophoretic transport problems of technological interest.","palabras_clave":"Electrophoresis|Fluid mechanics |Electrochemical transport| Finite element computation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1797,"idioma_id":6,"titulo":"Reseña Alexandre Dézé, Le Front national : à la conquête du pouvoir ?, Alexandre Dézé, Paris, Armand Colin, 2012, 192 p.","resumen":"La reseña se propone analizar una de las últimas obras dedicadas al Frente Nacional y una de las primeras en retrazar toda la historia de dicha organización política a partir de una análisis sociológico de la producción partidaria. A partir del trabajo en cuestión podemos repasar igualmente una larga literatura sobre la organización frontista en sus diversas aristas.","palabras_clave":"Nationalisme |Organisation partisane |Front national"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1799,"idioma_id":4,"titulo":"SOCIAL INEQUALITY, ENVIRONMENTAL JUSTICE AND WATER POLICY IN BUENOS AIRES","resumen":"Privatisation of potable water and sanitation services in the Metropolitan Area of Buenos Aires during the 1990s led to important consequences in terms of investment and equality in the provision of the services.  A new period was started in 2006 with the creation of the State-run company Agua y Saneamientos Argentinos SA, which became responsible for managing the provision of water and sewerage services in the region.  Today, the company has to deal with the historical backwardness in terms of investment, the growing pressure from the population demanding access to the services, and the significant inequality of the covered area.  On the other hand, due to the public impact of the court case regarding the sanitation of Matanza-Riachuelo basin, different territorial collectives have reformulated their demands for infrastructure works by including environmental terms.  Besides, the Supreme Court of Justice has required the joint coordination of the works by Agua y Saneamientos Argentinos SA and the Authority of the basin.  This means that water and sanitation management must answer to a great variety of actors and be able to operate in highly conflictive areas while meeting, at the same time, the environmental goals.  This article describes the main actors involved in water and sanitation management in the Metropolitan Area of Buenos Aires and their approaches to the new plans of expansion of the services.  The focus is to identify the opposing interests in terms of the distribution (which territories are the priority for the expansion of the water and sanitation networks); the implementation timetable (how to define the order of the works); and the emergence of different criteria of social and environmental justice. To this effect, we present an in-depth analysis of interviews to public officers, technicians and representatives of social organisations.","palabras_clave":"gestión integrada del agua|vulnerabilidad social|desigualdad social"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1800,"idioma_id":5,"titulo":"Variaciones en el consumo de camélidos durante el Período de Desarrollos Regionales: Una perspectiva local","resumen":"En este trabajo se presenta un análisis comparativo de conjuntos zooarqueológicos procedentes de distintos contextos funcionales contemporáneos del sitio Bilcapara (Departamento de Potosí, Bolivia), un asentamiento residencial conglomerado del Período de Desarrollos Regionales (900-1450 DC). Se observan contrastes en la representación taxonómica y anatómica de camélidos, relacionados con la circulación de recursos silvestres y las trayectorias post-matanza de algunas unidades anatómicas. Se argumenta que estos patrones dependen de las escalas de consumo y contextos de uso de la fauna involucrados en cada caso. Asimismo, se sostiene que los estudios zooarqueológicos a múltiples escalas, que contemplen la variación local en sitios internamente diferenciados a nivel funcional, son una vía complementaria para ampliar el conocimiento sobre las pautas económicas de las sociedades prehispánicas del Sur Andino.","palabras_clave":"ZOOARQUEOLOGIA DE CAMELIDOS|ESCALAS DE CONSUMO|PERIODO DE DESARROLLOS REGIONALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1801,"idioma_id":4,"titulo":"Machaeridians from the Middle and Upper Ordovician of the Argentine Precordillera","resumen":"The machaeridians are marine Palaeozoic annelids, which developed a dorsal skeletoncomposed of calcite plates, achieving a world wide distribution from the EarlyOrdovician to the Middle Permian. The absence of records from this group is notable inArgentina in spite of intense studies of Palaeozoic rocks. This fact can be assigned tobiases in the sampling or because of preservation problems. Machaeridian sclerites ofthe families Plumulitidae and Turrilepadidae collected in Middle and Upper Ordovicianrocks from the San Juan Precordillera, Argentine, are described here for the first time.Plumulites sp. is recorded in early Darriwilian strata from the Gualcamayo Formationexposed in the western flank of the Cerro La Chilca locality. Plumulitid and turrilepadidsclerites are described from the upper member of the Los Azules Formation (lateSandbian) in the Cerro Viejo de Huaco area. The material of the Los Azules Formationis the first record of turrilepadid in Sandbian rocks, which are scarce in Ordoviciansuccessions. The referred strata bear pelagic, benthic and nektobenthic faunalassemblages, constituting a similar taphocoenosis preserved in shales and calcareoussilty shales related to transgressive events. The record of machaeridians expands ourknowledge of the Ordovician biotas from Argentina and provides new information onthe palaeobiogeographical distribution of this Palaeozoic annelid group.","palabras_clave":"MACHAERIDIANS|ANNELIDA|PALAEOECOLOGY|ARGENTINE PRECORDILLERA|MIDDLE-UPPER ORDOVICIAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1802,"idioma_id":4,"titulo":"A Design Method for Active High-CMRR Fully-Differential Circuits","resumen":"Abstract: A simple method for designing instrumentation fully-differential(FD) circuits based on standard single-ended (SE) operational amplifiers (OAs)is presented. It departs from a SE prototype that verifies the desireddifferential-mode transfer function, thereby leading to FD versions of thecircuit. These circuits have a high common mode rejection ratio (CMRR),independent of component imbalances, and a unity common-mode gain. Theproposed method does not allow the design of common-mode response, but itdoes verify common-mode stability, thus ensuring stable FD circuits. It is intended for instrumentation applications in which high CMRRs are required.The proposed approach makes it possible to design and implement inverter and non-inverter topologies as well. Design examples and experimental data are presented. Using general-purpose OAs and 5%-tolerance components, the CMRR of these circuits easily exceeds 90 to 100 dB.","palabras_clave":"instrumentation circuits|differential circuits|fully-differential processing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1803,"idioma_id":5,"titulo":"Factores que influyen en la lentificación del cursado de las Carreras de Ingeniería  desde la perspectiva de los estudiantes. Estudio exploratorio en la UNCAus.","resumen":"The article focuses on the enlargement of the studies in engineering careers in Argentina. The study presents qualitative analyses in order to know how the academic, economic and socio-affective factors influence the academic performance of engineering students. Our findings could explain the main causes of the enlargement studies phenomenon from a perspective based on oral history testimony process.","palabras_clave":"student retention|enlargement|life history|qualitative study"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1806,"idioma_id":5,"titulo":"Ajuste, crisis y default. El FMI y la Argentina durante la gestión de De la Rúa (1999-2001)","resumen":"El presente trabajo se propone explicar el marcado cambio en la relación entre el FMI y la Argentina durante la gestión de la Alianza, que en un lapso muy breve pasó de un vínculo cooperativo, caracterizado por la aprobación de un programa en línea con lo planteado por el gobierno y el otorgamiento de elevados créditos, a uno altamente conflictivo, reflejado en la intolerancia del Fondo ante los sucesivos incumplimientos de las metas económicas y, finalmente, la suspensión del financiamiento que determinó la caída del régimen de convertibilidad a finales de 2001. Se estudian los procesos de negociación entre el FMI y el gobierno a partir de un esquema de doble nivel, que supone que las estrategias determinan la configuración y condicionan el resultado de las negociaciones. Se propone que la coincidencia de intereses contribuyó a que la relación entre el Fondo y el gobierno fuera cooperativa hasta comienzos de 2001, cuando se otorgó el ?blindaje?. Pero la insistencia en mantener un régimen cambiario-monetario insostenible, el endurecimiento de la política financiera de los EE. UU. y la consolidación de una posición intransigente en el FMI debilitaron la posición negociadora del gobierno y alentaron la implementación de una estrategia confrontativa por parte del organismo. Esto determinó el aumento de la conflictividad en las negociaciones y la configuración de un escenario menos favorable para la continuidad de la convertibilidad.","palabras_clave":"Argentina|FMI|Negociaciones|Convertibilidad|Default"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1807,"idioma_id":5,"titulo":"MA QUÉ y OTRA QUE: dos marcadores de descalificación del español rioplatense","resumen":"En este trabajo, se analizan las instrucciones semántico-argumentativas contenidas en dos marcadores especializados en operaciones de descalificación: ma qué y otra que. Después de señalar los vínculos con la negación metadiscursiva, se propone una descripción polifónico-argumentativa que busca dar cuenta de las diferencias que estos marcadores, propios del español rioplatense coloquial, presentan en relación con los discursos que descalifican y con la rectificación que habilitan. Se concluye que mediante el marcador evidencial ma qué se rechaza siempre fuertemente un marco de discurso ajeno, por lo que su enunciación siempre pone en evidencia un conflicto conversacional. Mediante otra que, en cambio, se descalifica un punto de vista previo del propio locutor o ajeno, pero aceptado por él, de modo que la rectificación que sigue puede leerse como una autocorrección con efecto siempre ascendente.","palabras_clave":"MARCADORES DE DISCURSO|DESCALIFICACION|EVIDENCIALIDAD|PERIFRASIS DE FUTURO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1808,"idioma_id":4,"titulo":"Differential modulation of tumor cell proliferation and their endocannabinoid system by  polyunsaturated fatty acids","resumen":"Experimental, clinical and epidemiological evidences suggest that&nbsp; quantity and quality of dietary polyunsaturated fatty acids (PUFA) play a significant role&nbsp; in the development of cancer. But the mechanisms involved in this interaction(s) between dietary intake of PUFAs and cancer is not clear. Cannabinoids are known to have growth modulatory actions. Hence, we analyzed the effect of&nbsp; supplementation of&nbsp; ù6 and ù3 PUFAs (essential fatty acids, EFA), saturated and monounsaturated (non EFA) fatty acids on the growth of tumor cells and changes in their endocannabinoid content.&nbsp; It was observed that both arachidonic acid and eicosapentaenoic acid (as representative of ù-6 and ù-3 fatty acids respectively) inhibited the growth of human glioblastoma (T98G) and breast cancer (MCF7) cells respectively while palmitic acid and oleic acid enhanced their growth. AA enhanced arachidonoylethanolamide (anandamide, AEA) levels in T98G cells without any effect on this indice in MCF-7 cells, while EPA was ineffective. These results indicate that&nbsp; PUFAs","palabras_clave":"fatty acids|cell proliferation|endocannabinoid|human tumoral cell lines"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1809,"idioma_id":4,"titulo":"New species of Epacanthion (Nematoda: Thoracostomopsidae) from Patagonia coast, Río Negro and Chubut, Argentina","resumen":"Two new free-living marine nematodes belonging to the family Thoracostomopsidae, subfamily Enoplolaiminae and the genera  Epacanthion are described from Patagonian coastal areas, R&#305;´o Negro and Chubut provinces of Argentina. In Epacanthion bicuspidatum  sp. nov. the main features are: two cusps on distal mandible end; presence of two rings of eight setae in the cervical  region; and eight crown-shaped setae along the body, presence of one supplement distant two cloacal body diameter (cbd)  from cloacae, gubernaculum and short spicule. Epacanthion ampullatum sp. nov. is characterized by having a tubular and  long pre-cloacal supplement, short spicule, presence of gubernaculum, presence of three long setae on the tip of the tail, the presence  of one supplement distant three cbd from cloacae and the presence of two small cusps on the distal end of the mandible.","palabras_clave":"DESCRIPTION|SYSTEMATICS|PATAGONIAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1810,"idioma_id":4,"titulo":"Nonlinear dynamic analysis of an optimal particle damper","resumen":"We study the dynamical behavior of a single degree of freedom mechanical system with a particle damper. The particle (granular) damping was optimized for the primary system operating condition by using an appropriate gap size for a prismatic enclosure. The particles absorb the kinetic energy of the vibrating structure and convert it into heat through the inelastic collisions and friction. This results in a highly nonlinear mechanical system. Considering linear signal analysis, state space reconstruction, Poincaré sections and the determination of maximal Lyapunov exponents, the motion of the granular system inside the enclosure is characterized for a wide frequency range. With the excitation frequency as control parameter, either regular or chaotic motion of the granular bed is found and the influence on the damping is analyzed.","palabras_clave":"PARTICLE DAMPER|NONLINEAR DYNAMICS|LYAPUNOV EXPONENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1811,"idioma_id":4,"titulo":"Plant functional diversity and carbon storage - an empirical test in semi-arid forest ecosystems","resumen":"Summary  1. Carbon storage in vegetation and soil underpins climate regulation through carbon sequestration.  Because plant species differ in their ability to capture, store and release carbon, the collective functional  characteristics of plant communities (functional diversity) should be a major driver of carbon  accumulation in terrestrial ecosystems.  2. Three major components of plant functional diversity could be put forward as drivers of carbon  storage in ecosystems: the most abundant functional trait values, the variety of functional trait values  and the abundance of particular species that could have additional effects not incorporated in the  rst two components.  3. We tested for associations between these components and carbon storage across 16 sites in the  Chaco forest of Argentina under the same climate and on highly similar parental material. The sites  differed in their plant functional diversity caused by different long-term land-use regimes.  4. We measured six plant functional traits in 27 species and weighted them by the species abundance  at each site to calculate the community-weighted mean (CWM) and the functional divergence  (FDvar) of each single trait and of multiple traits (FDiv). We also measured plant and soil carbon  storage. Using a stepwise multiple regression analysis, we assessed which of the functional diversity  components best explained carbon storage.  5. Both CWM and FDvar of plant height and wood-specic gravity, but no leaf traits, were retained  as predictors of carbon storage in multiple models. Relationships of FDvar of stem traits and FDiv  with carbon storage were all negative. The abundance of ve species improved the predictive power  of some of the carbon storage models.  6. Synthesis. All three major components of plant functional diversity contributed to explain carbon  storage. What matters the most to carbon storage in these ecosystems is the relative abundance of  plants with tall, and to a lesser extent dense, stems with a narrow range of variation around these  values. No consistent link was found between carbon storage and the leaf traits usually associated  with plant resource use strategy. The negative association of trait divergence with carbon storage  provided no evidence in support to niche complementarity promoting carbon storage in these forest  ecosystems.","palabras_clave":"Carbon stocks|Climate change mitigation|Ecosystem services|Functional divergence|Functional identity|Functional traits|Land use change|Mass ratio hypothesis|Niche complementarity|Semi-arid Chaco forest"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1812,"idioma_id":5,"titulo":"Prevalencia del ácaro Ornithonyssus bursa Berlese, 1888 (Mesostigmata: Macronyssidae) en un ensamble de aves (Passeriformes) de bosques del centro de la Provincia de Santa Fe, Argentina","resumen":"El ácaro Ornithonyssus bursa parasita a diversas especies de aves de regiones tropicales y subtropicales. En el Neotrópico es responsable de causar importantes pérdidas económicas por afectar a aves comerciales. También es vector de enfermedades que afectan tanto a las aves como al hombre. En el presente estudio, se examinó exhaustivamente un ensamble reproductivo de aves del orden Passeriformes en dos sitios de la región del Espinal de la provincia de Santa Fe, Argentina, con el objetivo de describir las asociaciones parásito-hospedador para detectar diferencias de prevalencias en sus hospedadores naturales. De 55 especies examinadas, 28 estuvieron parasitadas, de las cuales las especies más afectadas fueron el hornero (Furnariidae) Furnarius rufus (49,4%), el tordo renegrido (Icteridae) Molothrus bonariensis (40%) y el jilguero (Emberizidae) Sicalis flaveola (48,4%). M. bonariensis es una especie parásita y en el área de estudio parasita principalmente a F. rufus, mientras que S. flaveola utiliza nidos abandonados de F. rufus, por lo que se podría concluir que O. bursa está altamente asociado a nidos de hornero.","palabras_clave":"Ornithonyssus bursa|ácaros|nidos|Furnarius rufus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1813,"idioma_id":4,"titulo":"Identification of toxin genes encoding Cyt proteins from standard and Argentine strains of Bacillus thuringiensis","resumen":"Polymerase chain reaction-restriction fragment length polymorphism methods for identification of cyt subclasses from Bacillus thuringiensis were established. Eight of 68 standard and ten of 107 Argentine B. thuringiensis strains harbor at least one cyt gene. The combination of cyt1Aa\/cyt2Ba genes was identified in four standard and in ten native strains, whereas the cyt1Ba, cyt2Aa and cyt2Bb genes alone and the cyt1Ab\/cyt2Bc genes together were found in four different standard strains respectively. The cyt2Ba genes from three B. thuringiensis svar israelensis strains and two Argentine B. thuringiensis strains were cloned, sequenced and designated as cyt2Ba10 to cyt2Ba14   respectively. These results suggest that these methods are relevant   tools for identification of toxin genes encoding Cyt proteins in B. thuringiensis.","palabras_clave":"Bacillus thuringiensis  |cyt1 |cyt2|PCR-RFLP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1816,"idioma_id":4,"titulo":"Human occupations in the mountains of central Tierra del Fuego: an archaeological approach","resumen":"The aim of this paper is to inform about the results of archaeological investigations carried out up to now in the central strip of Isla Grande de Tierra del Fuego, the main island of the fuegian archipelago. The central sector of the island is a mountainous and woody environment, characterized by development of sub Antarctic forest as well as by its various environments and microenvironments with different resources.   The investigation search to evaluate the interrelationship between environment, resources and population dynamics in this area, that we consider as a key to understand the dynamics of mobility throughout the island.  It is organized around hypothesis regarding differential resources supply in the various environments of the area, and the possible circulation of hunter-gatherers, as well as the role of both factors in the variability of the archaeological record.","palabras_clave":"HUNTER-GATHERERS|SELKNAM|LANDSCAPE|TIERRA DEL FUEGO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1817,"idioma_id":4,"titulo":"HARMONIC DISTURBANCE REJECTION CONTROL FOR MAGNETIC FIELD COMPENSATION APPLICATIONS","resumen":"A simple control strategy was studied  for harmonic disturbance rejection in magnetic field compensation  systems for low-field magnetic resonance techniques. The strategy is  based on the simultaneous action of a conventional PID and a  selective harmonic-compensation controllers. The system consists of a  set of compensating coils fed by independent current sources driven  by a digital controller. A series of hall magnetic sensors close the  control loop. Despite its simplicity, it is shown that the  performance of the dual controller improves within the frequency  range where the waterbed effect becomes dominant, by selectively  enhancing the rejection of the harmonic component. The proposed  solution is particularly useful for selective harmonic rejection of  slowly varying frequency and amplitude dependent harmonic  perturbations. An extension to multiple-harmonic components  perturbations is possible.   ","palabras_clave":"Automatic frequency control|Waterbed effect|harmonic rejection|periodic control"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1818,"idioma_id":5,"titulo":"Taxonomía y filogenia de un grupo de lagartos amenzados: El grupo de Liolaemus anomalus (Iguania: Liolaemidae).","resumen":"El género Liolaemus, es uno de los grupos naturales con mayor cantidad de especies dentro de Iguania, está formado por dos subgéneros y varios grupos monofiléticos. Uno de estos, es el grupo monofilético de Liolaemus anomalus, uno de los clados con mayor cantidad de arreglos taxonómicos propuestos. Este conjunto de Liolaemus está representado por un escaso número de especies las cuales tienen baja densidad poblacional. Se distribuye desde el centro sur de Catamarca hasta el suroeste de La Pampa, Argentina. Las especies que integran este clado están asociadas a ambientes áridos y salobres, con escasa vegetación y expuestas a elevadas temperaturas, siendo lagartijas ovíparas e insectívoras y sin dimorfismo sexual. Son taxa muy difíciles de observar y varias especies y poblaciones están amenazadas debido principalmente a factores antrópicos.  En este trabajo, se realiza una revisión taxonómica y un análisis filogenético del grupo de Liolaemus anomalus. En la matriz morfológica utilizada para los análisis filogenéticos, se describen nuevos caracteres informativos para el clado y el género, que ayudan a clarificar las relaciones internas del grupo. Como apoyo a la metodología cladística, se realizaron análisis estadísticos (MANOVA), con el fin de efectuar un estudio detallado de los caracteres morfométricos.   También se realiza una redescripción formal de Liolaemus anomalus, Liolaemus ditadai, Liolaemus lentus y Liolaemus pseudoanomalus, con base en nuevos ejemplares colectados en diversas campañas y utilizando caracteres no analizados en las descripciones originales. Además se describen tres nuevas especies para la ciencia, se aportan datos que actualizan el conocimiento de las diferentes especies que integran el grupo y se analizan las congruencias con las hipótesis filogenéticas presentadas por otros autores.   Los resultados filogenéticos obtenidos aportan evidencia que justifican la descripción de estas tres nuevas especies y se propone una nueva hipótesis de parentesco para el grupo de Liolaemus anomalus.","palabras_clave":"LIOLAEMUS|CLADISTICA|ESTADISTICA|NUEVAS ESPECIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1819,"idioma_id":4,"titulo":"A new species of Heteronybelinia (Cestoda: Trypanorhyncha) from Sympterygia bonapartii (Rajidae),  Nemadactylus bergi (Cheilodactylidae), and Raneya brasiliensis (Ophidiidae) in the southwestern Atlantic, with comments on host specificity of the genus.","resumen":"Adults and plerocercoids of a new species of Heteronybelinia (Trypanorhyncha,  15 Tentaculariidae) were recovered from the skate Sympterygia bonapartii  16 (Rajiformes: Rajidae) and two species of teleosts, Raneya brasiliensis (Ophidi-  17 formes: Ophidiidae) and Nemadactylus bergi (Perciformes: Cheilodactylidae),  18 respectively. Heteronybelinia mattisi n. sp. differs from its congeners in its  19 possession of a tentacular armature consisting of hooks with slight differences in  20 size and shape on opposite surfaces of the tentacle (uncinate with rounded bases  21 on the bothrial surface and uncinate with elongate bases on the antibothrial  22 surface), without a characteristic basal armature, hooks increasing in size toward  23 the tip of the tentacles, and pars bothrialis slightly overlapping with bulbs. The  24 description of Heteronybelinia is emended regarding the distribution of testes to  25 include species without postovarian testes (H. palliata and H. mattisi), and  26 without testes anterior to cirrus sac on the poral side (H. robusta and H. mattisi).  27 Host data are summarized for all 15 valid species of Heteronybelinia. Host  28 specificity of adults and plerocercoids of Heteronybelinia is variable among  29 species, the adults being more host specific than the plerocercoids. With the  30 exception of H. mattisi, the definitive hosts of all species of Heteronybelinia for  31 which adults are known include carcharhiniform sharks. Heteronybelinia mattisi  32 seems to have oioxenous specificity for its definitive batoid host, S. bonapartii,  33 and to be more specific for the intermediate hosts than most of its congeners.","palabras_clave":"TRYPANORHYNCHA|PECES |MAR ARGENTINO|TENTACULARIDAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1820,"idioma_id":4,"titulo":"Determination of one-dimensional spherically aberrated point spread function in depth profiling by confocal Raman microscopy","resumen":"We present a simple experiment that allows the complete and direct characterization of the point spread function (PSF) in refraction-aberrated depth profiling experiments with confocal Raman microscopy. We used a wedge-shaped solid polymer film to induce refraction aberrations on the response of an infinitesimally thin Raman scatterer, represented by a polished silicon wafer. The system, with the film pasted on top of the Si wafer, was probed by a depth slicing technique under a dry-optics configuration. Post-acquisition processing of the Si and polymer intensity maps allowed the reconstruction of the axial PSF spatially resolved each 1 &#956;m or less in the z-axis and for virtually continuous values of focusing depth. In agreement with theory, we found that PSF broadens asymmetrically with focusing depth, with a marked shift in the focus point. From the shape of PSF, we obtained values of depth resolution within the film that confirm that axial discrimination is not drastically deteriorated, as suggested by previous works, and that confocal aperture effectively reduces the collection volume even under severe refraction interference. Copyright © 2013 John Wiley & Sons, Ltd.","palabras_clave":"CRM|DEPTH PROFILING|PSF|REFRACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1821,"idioma_id":5,"titulo":"ESTUDIO SISTEMÁTICO DEL GÉNERO SUDAMERICANO DIPLOLEPIS  (APOCYNACEAE)","resumen":"A taxonomic treatment of the genus Diplolepis is here presented. Based on molecular and biogeographical information recently published, this group is monophyletic and its geographical distribution is restricted to southwestern South America. The study comprised the analysis of herbarium specimens including nomenclatural types, supplemented with collections and observation of species in the field. This paper describes the variation in the morphology of the genus, including habit, stems, leaves, inflorescence, calyx, corolla, corona, gynostegium, pollinia, fruits and seeds. The morphological and distributional differences between Diplolepis and related genera are discussed. A key to differentiate the species of the genus is here given. Within each species we provide the valid name, synonyms, description of vegetative and reproductive morphological characters, geographical distribution, ecology, uses, common names, phenology, iconography and specimens examined. A lectotype is designated for D. viridis.","palabras_clave":"Apocynaceae|Asclepiadoideae|Morphology|Taxonomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1823,"idioma_id":4,"titulo":"Simulation of a baroclinic wave with the WRF regional model: sensitivity to the initial conditions in an ideal and a real experiment","resumen":"A sensitivity study to perturbations in the initial conditions in a simulated evolution of a baroclinic wave  using the Weather Research and Forecasting (WRF) regional model is discussed in this paper. With the goal of analysing  the impacts of these perturbations in the context of weather forecast and also with the aim of exploring the presence of  preferred directions of growth in the errors, two cases were analysed: an ideal experiment using a case study available from  the WRF set-up and a simulation of a real evolution of a mid-latitude cyclone over Southeastern South America (SESA)  and the Atlantic Ocean. In the ideal experiment two spatial structures were considered for the perturbations, random and  sinusoidal noise, while for the real experiment only sinusoidal structures were considered. These perturbations were then  applied to the initial conditions of temperature and zonal wind. Additionally, simulations with an increment in atmospheric  moisture were performed for the real experiment. It was found in both real and ideal cases that the temperature errors tend  to organize in a preferable direction of growth, although this direction changes depending on the case considered. Results  also show that perturbations in temperature field lead to larger error than perturbing the zonal wind. Finally, the increment  of moisture did not produce significant changes in the distribution or intensity of the errors in the real case.","palabras_clave":"perturbations|WRF model|initial conditions|Southeastern South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1824,"idioma_id":4,"titulo":"Multiparasitism of Piezodorus guildinii eggs by Telenomus podisi and Trissolcus urichi","resumen":"Multiparasitism involves competition between larvae inside the host. Telenomus podisi (Ashmead) and  Trissolcus urichi (Crawford) (Hymenoptera: Platygastridae) are solitary egg parasitoids of Piezodorus  guildinii Westwood (Hemiptera: Pentatomidae), an important soybean pest. Egg masses partially parasitized  by one species were offered to females of the other species. Both species attacked randomly unparasitized  and parasitized hosts. Emergence from multiparasitized eggs was greater for Trissolcus urichi than for T.  podisi , although it was lower than emergence from eggs parasitized by T. urichi alone. Emergence of each  species was independent of the order in which they parasitized and of time elapsed between ovipositions.  Progeny sex ratio obtained from multiparasitized and from parasitize eggs were similar for both parasitoids.  Our results suggest that T. urichi is a better intrinsic competitor than T. podisi for P. guildinii eggs. In the  field, however, T. podisi was the dominant species, and T. urichi could be using other pentatomid eggs as  resource.","palabras_clave":"Hemiptera |Pentatomidae |Hymenoptera |Competition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1825,"idioma_id":5,"titulo":"El cambio climático y las condiciones ambientales en los Partidos de La Plata, Berisso y Ensenada, Provincia de Buenos Aires: Aspectos preliminares","resumen":"Se presentan las tareas iniciales realizadas enrelación al proyecto Efectos del cambio climático en las condicionesambientales de los Partidos de Berisso, Ensenada y La Plata, que es financiado porla Universidad Nacional de La Plata en el marco del programa de ?Proyectos de innovación ytransferencia en áreas prioritarias (PIT-AP). Con este proyecto, iniciado en2011, se propone avanzar en el conocimiento y evaluación de la influencia quegeneran los cambios climáticos en las condiciones ambientales del borde sur delRío de La Plata. Estoscambios pueden producir importantes efectos en el desarrollo socioeconómico yen los riesgos a que se encuentra sometida esta región. Debido a la escasez dedatos básicos y la falta de un conocimiento adecuado de las condicionesambientales de la región, se están realizando los estudios geológicos,geomorfológicos, hidrológicos, ecológicos y topográficos necesarios para el modeladode posibles escenarios de los cambios climáticos.","palabras_clave":"CAMBIO CLIMATICO|CUENCAS HIDROGRAFICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1826,"idioma_id":5,"titulo":"La Educación de Jóvenes y Adultos como corolario de los privilegios de clase en la educación","resumen":"El objetivo del artículo consiste en estudiar cómo se configuró históricamente la educación y alfabetización de adultos en Argentina. La intención es desnaturalizar la existencia de la Educación de Jóvenes y Adultos y problematizarla como una construcción producto de procesos sociales, históricos, políticos, educativos y pedagógicos. De problema coyuntural en momentos de conformación del sistema educativo, se convirtió en un problema estructural. El proceso histórico de conformación de la educación de adultos como subsistema fue producto y productor de procesos de diferenciación social y educativa. La conformación de la educación de adultos se configuró como corolario de los privilegios de clase en la educación.","palabras_clave":"Educación de Jóvenes y Adultos|Alfabetización de adultos|Historia de la Educación|Diferenciación Educativa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1827,"idioma_id":5,"titulo":"Cultura, Organizaciones y Antropología. Una Revisión Crítica","resumen":"El concepto de cultura organizacional aparece como una dimensión clave de problematización en el campo de la antropología de las organizaciones. Si bien este ámbito de estudios se encuentra en un estado de desarrollo incipiente, se ha coincidido en definir a la perspectiva antropológica acerca de las organizaciones a partir de una discusión explícita con los postulados y discursos producidos por la teoría de la administración. Consideramos que en este movimiento se puede correr el riesgo de no reconocer los procesos a partir de los cuales la cultura se ha convertido en una categoría reflexiva frecuente en el campo de las organizaciones contemporáneas. En base a esto, este trabajo sostiene que una adecuada conceptualización antropológica de los ámbitos organizacionales debería poder dar cuenta de los usos y sentidos que dan los actores (incluidos los teóricos administrativos) a la semántica cultural.","palabras_clave":"ANTROPOLOGÍA DE LAS ORGANIZACIONES|CULTURA ORGANIZACIONAL|ADMINISTRACIÓN |ETNOGRAFÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1828,"idioma_id":4,"titulo":"MgAl2O4 spinel prepared by mechanochemical synthesis used as a support of multimetallic catalysts for paraffin dehydrogenation","resumen":"The catalytic performance in nbutane dehydrogenation of bimetallic PtSn, PtGa and PtIn, and tri metallic PtSnIn and PtSnGa catalysts (with low metal contents) supported on a MgAl2O4 prepared by a novel mechanochemical synthesis was evaluated both in flow and pulse equipment. The influence of the addition ofdifferent promoters (Sn, Ga and In) to Pt on the activity, selectivity and deactivation in the nbutane dehydro genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.mechanochemical synthesis was evaluated both in flow and pulse equipment. The influence of the addition ofdifferent promoters (Sn, Ga and In) to Pt on the activity, selectivity and deactivation in the nbutane dehydro genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.metallic PtSnIn and PtSnGa catalysts (with low metal contents) supported on a MgAl2O4 prepared by a novel mechanochemical synthesis was evaluated both in flow and pulse equipment. The influence of the addition ofdifferent promoters (Sn, Ga and In) to Pt on the activity, selectivity and deactivation in the nbutane dehydro genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.mechanochemical synthesis was evaluated both in flow and pulse equipment. The influence of the addition ofdifferent promoters (Sn, Ga and In) to Pt on the activity, selectivity and deactivation in the nbutane dehydro genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.genation reaction was studied. Stability experiments through successive reactionregeneration cycles were carried out for selected catalysts. In order to correlate the properties of the metallic phase of the catalysts with thecatalytic behavior, several characterization techniques were used, such as test reactions of the metallic phase(cyclohexane dehydrogenation and cyclopentane hydrogenolysis), TPR, XPS, H2 chemisorption and TEM. Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.Bimetallic PtSn catalyst has a better catalytic behavior than PtIn and PtGa ones. For PtSnM (M: In or Ga) catalysts, whereas Ga addition to the bimetallic catalyst does not practically modify the dehydrogenation performance, the addition of In produces an increase of the activity and the selectivity to butenes. Characterizationresults indicate the presence of geometric effects for the PtSn catalyst, and geometric and electronic effects forPtIn and PtGa ones. For trimetallic catalysts, the presence of a close contact between Pt, Sn and In or Ga inboth trimetallic catalysts was found, mainly due to geometric effects like blocking and dilution of the active sitesby the promoters. In stability experiments, the trimetallic PtSnIn\/MgAl2O4 catalyst clearly displays the best cat alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.alytic performance along reactionregeneration cycles, though PtSnGa and PtSn catalysts also showed a verygood behavior through the successive cycles. The characterization of these catalysts after cycles shows that theirmetallic phases are slightly modified along the cycles.","palabras_clave":"DESHIDROGENACION DE PARAFINAS|SINTESIS MECANOQUÍMICA|CATALIZADORES MULTIMETALICOS|CARACTERIZACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1829,"idioma_id":5,"titulo":"Infertilidad en Latinoamérica. En busca de un nuevo modelo","resumen":"En este trabajo argumento que debería tomarse a la infertilidad como un problema de salud pública y analizo la situación de infertilidad en Latinoamérica. Sin embargo, no apoyo una extensión y copia del modelo privado de tratamiento al ámbito público. Argumento, en cambio, a favor de la necesidad de repensar el modelo de implementación de las técnicas de asistencia en la reproducción con una mirada diferente, que debería ser amplia e inclusiva. La infertilidad está directamente ligada a la salud de la mujer, por lo tanto un enfoque legítimo desde la salud pública, para Latinoamérica, debiera formar parte de una aproximación integral a la salud sexual y reproductiva de las personas. Uno de mis objetivos es tener particularmente en cuenta el flagelo de la infertilidad secundaria en la región. Así, la nueva mirada desde la salud pública que defiendo implica hacerse cargo de la salud sexual y reproductiva de la mujer desde sus inicios, abarcando las diferentes etapas y problemas que ésta involucra, ya sea desde la adolescencia para evitar un embarazo no deseado (cuidarla para evitar enfermedades de transmisión sexual así como abortos inseguros); como en la juventud para lograr la maternidad y el hijo ansiado. También abordo el problema de la infertilidad desde una mirada ético- política. Pregunto por la falta de un planteo coherente y estratégico en Latinoamérica, sobre todo, desde el feminismo y desde posiciones progresistas.","palabras_clave":"REPRODUCCION ASISTIDA|INFERTILIDAD SECUNDARIA|SALUD PUBLICA|FEMINISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1830,"idioma_id":4,"titulo":"Cloprostenol treatment of feline open-cervix pyometra","resumen":"Treatment with cloprostenol, a prostaglandin synthetic analogue, was evaluated in five queens with open-cervix pyometra. Cloprostenol was administered (5 &#956;g\/kg body weight SC) on three consecutive days and amoxicillin (20 mg\/kg body weight IM) on seven consecutive days. Transient post-injection reactions caused by cloprostenol administration included diarrhea, vomiting and vocalizations. Reactions began as quickly as 10 mins after cloprostenol administration and lasted as long as 30 mins. All queens improved clinically after cloprostenol treatment and remained healthy until the end of the study, 1 year after treatment. All queens resumed normal estrous cycles without further treatment and two (40%) delivered a normal litter. In conclusion, use of cloprostenol is an acceptable treatment for open-cervix pyometra in queens.","palabras_clave":"CLOPROSTENOL|PYOMETRA|FELINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1831,"idioma_id":4,"titulo":"The Dark Glory of Criminals. Notes on the Iconic Imagination of the Multitudes","resumen":"This article explores the relationships between crime, collective responses to it, and the social production of so-called great criminals. It argues that crime, especially sexual and violent crime, produces significant imbalances in individuals habitually subject to instrumental actions, identitarian thinking and positive law. These imbalances are emotional as well as cognitive and, under certain conditions of communication, can generate states of multitude, that is, collective states linked to an intense affectivity and to the prevalence of mythic or symbolic thinking. These states reach their limits and become condensed in the mytho-historical figure of the great criminal. In this sense, great criminals are a function of such multitudinous states: points of imputation that concentrate and catalyze the affective imagination unleashed by collective effervescence.      ABSTRACTED\/INDEXED IN  SCOPUS, Google Scholar, EBSCO, CSA, Academic OneFile, Criminal Justice Abstracts, Current Abstracts, Current Index to Legal Periodicals, Gale, International Bibliography of Book Reviews (IBR), International Bibliography of Periodical Literature (IBZ), International Bibliography of the Social Sciences (IBSS), Legal Journals Index, OCLC, SCImago, Summon by Serial Solutions, The Philosopher´s Index","palabras_clave":"Crime|Multitude|Myth  |Great Criminals"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1832,"idioma_id":4,"titulo":"A New Social Physic. The Sociology of Gabriel Tarde and its Legacy","resumen":"This article aims to present a reconstruction of Gabriel Tarde?s micro-sociology in order to highlight its current relevance. The author of the article attempts to show that its distinction lies in taking the immense diversity of small social interactions as a starting point for the analysis of both face-to-face situations and large-scale institutions and social processes. Here the social field is described as made up of multiple propagations of desires and beliefs that spread from one individual to other, taking countless directions, interfering with each other, forming networks, and escaping them in search of new connections. The author attempts to show, also, that this point of view doesn?t deny  the existence of social systems but understands them as open ensembles of immanent, contingent, and partial relationships of collective beliefs and desires. This is why Tarde may be considered the founder of a molecular or micro-physical sociology.      CURRENT SOCIOLOGY is an official journal of the International Sociological Association  Abstracting\/Indexing:       Academic Index, Academic Search Elite, Academic Search Premier, Applied Social Sciences Index & Abstracts (ASSIA), Business Source Corporate, CD-ROM - International Bibliography of Book Reviews of Scholarly Literature in the Humanities and Social Sciences, CD-ROM - International Bibliography of Book Reviews of Scholarly Literature on the Humanities and Social Sciences, CD-ROM International Bibliography of Periodical Literature in the Humanities and Social Sciences, CD-ROM International Bibliography of Periodical Literature on the Humanities and Social Sciences, Current Contents \/ Social and Behavioral Sciences, DELNET - Developing Libraries Network (Members Only), Documentation in Public Administration, Educational Research Abstracts Online,  Expanded Academic Index,  Family Index, Family Index Database, Health Source, Human Resources Abstracts, IBZ: International Bibliography of Periodical Literature, IBZ: International Bibliography of Periodical Literature in the Humanities and Social Sciences, International Bibliography of Book Reviews of Scholarly Literature in the Humanities and Social Sciences, International Bibliography of Book Reviews of Scholarly Literature on the Humanities and Social Sciences, International Bibliography of the Social Sciences, International Institute for the Sociology of Law - IISL - Centre of Documentation Database, International Political Science Abstracts, MasterFILE Premier, Middle East Abstracts & Index, Newsearch, Online - International Bibliography of Book Reviews of Scholarly Literature in the Humanities and Social Sciences,  Online - International Bibliography of Book Reviews of Scholarly Literature on the Humanities and Social, Online - International Bibliography of Periodical Literature in the Humanities and Social Sciences,  Online - International Bibliography of Periodical Literature on the Humanities and Social Sciences,  Periodical Abstracts,  Psychological Abstracts,  PsycINFO,  SciVal,  Scopus,  Social Science Source,  Social Sciences Citation Index,  Social Sciences Index,  Social Services Abstracts,  SocINFO,  Sociofile,  Sociological Abstracts,  Sociology of Education Abstracts,  Southeast Asia Abstracts & Index,  SRM Database of Social Research Methodology,  SRM Database of Social Research Methodology,  Vocational Search,  Worldwide Political Science Abstracts","palabras_clave":"Gabriel Tarde|Micro-Sociology |Cartographic Knowledge |Assemblage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1833,"idioma_id":5,"titulo":"Los principales sistemas de cavernas cársticas de la Provincia del Neuquén.","resumen":"The Neuquén province exhibits one of the most valuable karst landscapes  of Argentina as it records the biggest limestone cavern, the Cuchillo Curá  System. The great development of it made speleologists extensively explore the  province, and up to now 111 caves have been topographied. They comprise  dissolutional caves in limestones and gypsum lithologies as well as volcanic  caves which as a whole constitute excellent examples of karts and pseudokarst  processes. The origin of these caves occurred during the Pleistocene-Holocene  times as a consequence of the reogenic corrosion of the hosting rocks under alternating  humid, cold to template climate. Yet, the present-day semiarid conditions have  driven most of them to an inactive hydraulic stage, although with minimum karst  processes still in progress. ","palabras_clave":"Cavernas|Karst|Neuquén|Sistema"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1834,"idioma_id":5,"titulo":"Jóvenes universitarios en la era digital. Primeras aproximaciones conceptuales","resumen":"Este artículo se propone reconstruir los perfiles y características socio-culturales de jóvenes estudiantes de la Universidad de la Plata. Más específicamente indaga en los accesos y usos predominantes de las nuevas tecnologías, el modo de informarse,la constitución de espacios de recreación y sociabilidad, con el in de interrogarnos acerca de su influencia en las experiencias políticas de los estudiantes.","palabras_clave":"jovenes estudiantes universitarios|perfiles socioculturales|nuevas tecnologías|experiencias políticas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1835,"idioma_id":5,"titulo":"En busca del espacio perdido","resumen":"Carlos Ríos tiene conciencia barroca; leer su obra es el pulso de la finitud; la estrechez de sentir que uno corre, irremediablemente, hacia el mismo lugar. Como en algunos sonetos de Quevedo (y no hallé cosa en qué poner los ojos \/ que no fuese recuerdo de la muerte) o en La lección de anatomía de Rembrandt la muerte aparece en toda su materialidad: ahí está, no lo olviden. Decir esto, sin embargo, es decir poco.                Por otro lado, se ha relacionado insistentemente sus recursos literarios a modos antropológicos; el mismo escritor consideró su primera novela como una antropología del desastre (Página\/12, 25 de marzo de 2009), lo que, contrariamente, nos permite leer un más allá de ese tipo de lectura. Decir que las novelas de Carlos Ríos son antropológicas es, también, decir poco. Obviemos que un etnógrafo es un investigador que estudia una comunidad ajena ingresando y conviviendo con ella, y que las tribus africanas de Manigua (2009) o el pueblo ucraniano de Cuaderno de Pripyat (2012) son para el escritor solamente puntos remotos del mapa. En Ríos no hay mirada etnográfica porque desaparece el elemento primario de la etnografía: la descripción. En Ríos hay, en cambio, una mirada política que no se preocupa por restablecer un estado de la cuestión. Por el contrario, hay un gesto político, anterior a cualquier deseo descriptivo, que es la conciencia del desastre.","palabras_clave":"CARLOS RÍOS|CUADERNO DE PRYPIAT|NARRATIVA CONTEMPORÁNEA|LITERATURA ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1836,"idioma_id":4,"titulo":"Roles of Trypanosoma cruzi calreticulin in parasite-host interactions and in tumor growth.","resumen":"In Latin America, there are about 10?12 million people infected with Trypanosoma cruzi, the agent of  Chagas? disease, one of the most important neglected tropical parasitism. Identification of molecular  targets, specific for the aggressor or host cells or both, may be useful in the development of pharmacological  and\/or immunological therapeutic tools. Classic efforts in Chagas? disease explore those  strategies. Although the immune system frequently controls parasite aggressions, sterile immunity is  seldom achieved and chronic interactions are thus established. However, laboratory-modified immunologic  probes aimed at selected parasite targets, may be more effective than their unmodified counterparts.  Calreticulin (CRT) from vertebrates is a calcium binding protein, present mainly in the endoplasmic reticulum  (ER), where it directs the conformation of proteins and controls calcium levels. We have isolated,  gene-cloned, expressed and characterized T. cruzi calreticulin (TcCRT). Upon infection, the parasite can  translocate this molecule from the ER to the surface, where it inhibits both the classical and lectin complement  pathways. Moreover, by virtue of its capacity to bind and inactivate first complement component  C1, it promotes parasite infectivity. These two related properties reside in the central domain of this  molecule. A different domain, amino terminal, binds to endothelial cells, thus inhibiting their angiogenic  capacity. Since tumor growth depends, to a large extent on angiogenesis, their growth is also inhibited.","palabras_clave":"IMMUNOLOGY|CALRETICULIN|TUMOR|COMPLEMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1838,"idioma_id":4,"titulo":"Long-term monitoring in the face of biotic and abiotic influences at a semiarid site in north-central Chile","resumen":"            Since 1989, we have conducted a  large-scale ecological experiment in semiarid thorn scrub of a national park in  north-central Chile. Initially, we focused on the role of biotic interactions  including predation, interspecific competition, and herbivory in small mammal  and plant components of the community. We utilized a reductionist approach with  replicated 0.56 ha fenced grids that selectively excluded vertebrate predators  and\/or larger small mammal herbivores such as the degu, Octodon degus.&nbsp; In this Data Paper we provide data on small  mammals captured, ephemeral and perennial plant cover, seed densities, and  rainfall over a 16-year periods, from 1989 through 2005.    ","palabras_clave":"CLIMATE|COMPETITION|PREDATION|SEMIARID ECOSYSTEM|SMALL MAMMALS|POPULATION DYNAMICS|SPECIES INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1839,"idioma_id":5,"titulo":"Efecto de la temperatura en la regeneración de especies leñosas del Chaco Serrano e implicancias  en la distribución actual y potencial de bosques","resumen":"La temperatura influye sobre los límites de distribución de las especies leñosas, actuando sobre los procesos asociados con la fase regenerativa de las plantas. Nos propusimos analizar su influencia en la distribución altitudinal del bosque chaqueño serrano y su potencial coexistencia con bosquecillos de altura en las Sierras Grandes de Córdoba. Se evaluó la regeneración a campo de dos especies del bosque serrano (Ruprechtia apetala y Lithraea molleoides) y la dominante en los bosquecillos de altura (Polylepis australis) abarcando el gradiente altitudinal completo de estas sierras (900-2700 m s.n.m.). En el  laboratorio  se  evaluó  la  germinación  bajo  cuatro  termo-períodos  representativos  de  las  condiciones del gradiente altitudinal. Polylepis australis germinó en los cuatro termo-períodos y en los siete niveles altitudinales  en  el  campo.  L.  molleoides  mostró  nula  germinación  a  bajas  temperaturas  (10\/5ºC)  en  el laboratorio, pero germinó y sus renovales sobrevivieron en todo el gradiente altitudinal en el experimento de campo. Ruprechtia apetala fue la más restringida, no estableciéndose por encima de 1500 m s.n.m. a campo, ni germinando a bajas temperaturas en el laboratorio. Los resultados obtenidos sugieren que, al menos en términos de reclutamiento y establecimiento de renovales, la franja altitudinal de 1400-1700 m s.n.m. de las Sierras Grandes de Córdoba, tiene potencialidad para albergar una comunidad de transición, con elementos leñosos del bosque serrano y de los bosquecillos de altura.","palabras_clave":"REGENERACIÓN|TEMPERATURA|GRADIENTE ALTITUDINAL|CHACO SERRANO|LÍMITE SUPERIOR DE BOSQUES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1841,"idioma_id":5,"titulo":"Las cocineras de La Capital. Lectoras, amas de casa, ecónomas, consumidoras y saberes femeninos: una experiencia rosarina, 1930-1945","resumen":"Las cocineras de La Capital?, es un artículo que, capitalizando los aportes de la historia de las mujeres, la historia sociocultural y la de la alimentación, comunica los pasos de una pesquisa alrededor del proceso de feminización de la transmisión escrita del saber culinario doméstico y la popularización de la producción derivada durante el período 1930-1945. La hipótesis sostiene que tal proceso involucró tareas de edición y publicación de recetas de cocina que, lejos de ser ingenuas, resultaron discursos prescriptivos y performativos en dirección a la educación de las amas de casa. La apuesta metodológica reside en leer de manera interpretativa las estrategias que al respecto generó el diario La Capital, tanto en las secciones femeninas como en la publicidad.","palabras_clave":"MUJERES|COCINA|TRANSMISION|SOCIEDAD DE CONSUMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1842,"idioma_id":4,"titulo":"Solubility of amphotericin B in water-lecithin-dispersions and lecithin-based submicron emulsions?.","resumen":"The aim of this work was to evaluate water-lecithin-dispersions (WLDs) as carriers for Amphotericin B (AmB) and to compare the drug solubility in WLDs and O\/W lecithin-based submicron emulsions (SMEs) in order to evaluate the influence of lecithin content on the dosage form solubilization of the active compound. WLDs and different SMEs with either 1.2 or 2.4% of lecithin were prepared. WLD with 2.4% lecithin show a 10-fold increase in solubilization of AmB compared with 1.2% lecithin WLD. SMEs with 1.2% lecithin show an increase of over 400 timesin solubilization compared with WLD containing the same concentration of lecithin, whereas SMEs with 2.4% lecithin show an increase of over 40 times compared with the corresponding WLD. Drug solubilization in SMEs with 2.4% lecithin is not significantly greater than in those containing 1.2% lecithin. The content of surfactant Brij 97® had a significant influence on drug solubilization in SMEs (P&lt;0.05). Results indicate that indicate that SMEs are proper systems to solubilize AmB. It can be assumed that solubilization is due to the formulation microstructure and not to theseparate components themselves.","palabras_clave":"Lecithin|dispersion|Amphotericin B|submicron emulsion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1843,"idioma_id":5,"titulo":"Reflexiones en torno a la transformación del cronotopo borde en corredor en la narrativa de María Rosa Lojo","resumen":"Este texto fue incluido en un volumen, cuya propuesta era la puesta en diálogo de diferentes trabajos críticos sobre la obra de M. R. Lojo. La problemática identitaria de los sujetos en tránsito -emigrantes, exiliados- en la obra de María Rosa Lojo constituye un eje vertebrador -no el único, desde luego, pero sí uno de los de mayor envergadura- de la totalidad de su obra, tanto ficcional como metaficcional. Desde sus primeros textos publicados: Visiones, Forma oculta del mundo, Esperan la mañana verde, todos ellos pertenecientes a su producción poética, y su primer volumen de cuentos titulado Marginales así como su apertura a la novelística con Canción perdida en Buenos Aires al Oeste, hasta el Libro de las Siniguales y del único Sinigual, peculiar relato cercano a los cuentos de hadas o de fadas, para ser más precisa, ya que el texto fue publicado en gallego por la editorial Galaxia Gutemberg en una edición realmente de lujo- y Bosque de ojos, volumen de micro-ficciones y otros textos breves, la presencia de dicha problemática es indiscutible.","palabras_clave":"MARÍA ROSA LOJO|IDENTIDAD|EXILIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1844,"idioma_id":4,"titulo":"Calculating effective growth rate from a random Leslie model: Application to incidental mortality analysis","resumen":"Demographic models are commonly used to study cetacean population dynamics and are characterized by a wide range of age classes. The primary building blocks are age-specific survival or mortality and birth rates, which can be combined using a Leslie matrix protocol to provide estimates of maximum possible rates of increase for population size. In this context, specific mortality data are valuable for modeling the viability of threatened species. Depletion of prey, pollution, and other anthropogenic disturbances are believed to have contributed to the decline of populations, but the evidence is less conclusive for these factors than for bycatch. In an attempt to estimate a population growth rate that incorporates uncertainties in vital parameters, we apply a random Leslie analysis to calculate effective growth rate for the time-dependent mean-value population. Here we provide the algorithm to implement it for a general 13×13 random survival model. An effective growth rate can be characterized by studying the time evolution of the mean-value population vector state (in an age-structured description). We show that the asymptotic behavior of the mean-value vector state, which characterizes the population growth rate when the model has random vital parameters, exhibits a value that is below previously expected potential estimations. We demonstrate the procedure using bibliographic revision data of the harbor porpoise (Phocoena phocoena) in Canadian waters, subjected to incidental mortality.","palabras_clave":"Random Leslie matrix|Effective growth rate|Uncertainty|Cetacean population dynamics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1845,"idioma_id":5,"titulo":"Los derechos en el primer peronismo, desafíos y rupturas.","resumen":"  En mi trabajo me propongo reflexionar sobre el lenguaje de derechos que dio forma y sentido a las reformas institucionales y sociales que dieron lugar a la ampliación inédita de derechos sociales bajo el primer preronismo. Mi interés se centra no tanto en la ampliación en sí, es decir en sus alcances y contenidos en materia de los nuevos derechos otorgados, sino más bien sobre el desplazamiento que este nuevo lenguaje involucró respecto a una tradición liberal de derechos que había prevalecido en la formación política argentina desde principios del siglo XX. ","palabras_clave":"Peronismo|derechos |discurso político|identidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1846,"idioma_id":4,"titulo":"Political discourse theory in the study of resistance movements: an alternative account of the human rights movement in Argentina","resumen":"My aim in this paper is to bring some light on the emergence and constitution of the human rights movement and discourse in Argentina and show how a political discourse theory perspective can actually contribute to the full understanding of new forms of social mobilization. To do this, I first look at the ways the human rights movement and discourse have been accounted for by the literature and I point at some of the common problems and difficulties found in most accounts. I argue that for a more satisfactory understanding of the constitution of this movement, special attention should be given to the process of political identification and articulation that was at the base of the movement´s emergence. In this way, I turn to explore the dislocatory effects that prompted the process of popular mobilization, and later to analyze the discursive conditions that made this new sociopolitical identity possible. Finally, I conclude with some remarks on how drawing on a discourse theory approach can help us to understand the formation of the human rights demand and to the study of new forms of social mobilization in general.","palabras_clave":"HUMAN RIGHTS|DISCOURSE |IDENTITY|POLITICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1847,"idioma_id":5,"titulo":"Vida y Muerte en el valle de San Francisco. Prácticas funerarias complejas y diversidad mortuoria en grupos de la selva pedemontana de Jujuy (Argentina)","resumen":"Toda sociedad transita el paso de un estado esencial a otro, el mundo de los vivos al de los muertos, mediante prácticas funerarias que varían en el espacio y en el tiempo. Por la multiplicidad de formas que asumen, son una importante fuente de información sobre diversas concepciones religiosas, acciones rituales y actividades económicas. Los restos  funerarios representan total o parcialmente a la sociedad que los dispuso y son el reflejo sintético de diversas conductas sociales altamente significativas por lo que su estudio es particularmente valioso. Se presentan en este trabajo diferentes prácticas funerarias registradas en poblaciones que ocuparon la región de la selva pedemontana en la actual  provincia de Jujuy (Argentina) (800 aC-500 dC.). Se discuten las implicancias de los datos registrados en relación a diversas formas de tratamiento de los difuntos y las prácticas asociadas con ellas, interpretadas como rituales de memorización de linajes endogámicos","palabras_clave":"PRACTICAS FUNERARIAS|ARQUEOLOGIA|SAN FRANCISCO|YUNGAS DE ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1848,"idioma_id":4,"titulo":"On the diagonalization of the Ricci flow on Lie groups","resumen":"The main purpose of this note is to prove that any basis of a nilpotent Lie algebra for which all diagonal left-invariant metrics have diagonal Ricci tensor  necessarily produce quite a simple set of structural constants; namely, the bracket of any pair of elements of the basis must be a multiple of one of them and only the bracket of disjoint pairs can be nonzero multiples of the same element.  Some applications to the Ricci flow of left-invariant metrics on Lie groups concerning diagonalization are also given.","palabras_clave":"Ricci Flow|Lie group"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1849,"idioma_id":5,"titulo":"La reflexión ético-científica en el ámbito académico de la FCEyN-UNMdP: una realidad posible","resumen":"P { margin-bottom: 0.21cm; }                      \t  \t  \t  \tP { margin-bottom: 0.21cm; }  En febrero de 2011 se creó la Comisión para el Desarrollo de un Espacio de Reflexión Ético-Científica, orientada a generar debate, reflexión y toma de posición desde la FCEyN-UNMdP ante temáticas de alcance científico que tengan impacto ambiental, económico, social y\/o cultural. Desde entonces se desarrollaron acciones concretas que incluyen declaraciones de la FCEyN-UNMdP en relación&nbsp; con la fumigación con agroquímicos y&nbsp; con especies en peligro de extinción, participación en una mesa multidisciplinaria de trabajo en la Municipalidad de Gral. Pueyrredón y generación de cursos de postgrado que demostraron que este espacio es una realidad posible y sostenible en el tiempo.                  ","palabras_clave":"Reflexión ética-científica|cursos posgrado|fumicaciones|problemática social"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1851,"idioma_id":5,"titulo":"La prevención como contraprestación: la instrumentalidad de la asistencia en la intersección de la política social y la política criminal","resumen":"El objetivo de este artículo es analizar las formas en que se han articulado los campos de la política social y la política criminal en las estrategias de prevención social del delito en Argentina durante el período 2000-2010, específicamente, las modalidades en que dichas estrategias problematizaron su relación con las intervenciones sociales, en particular con el ?sector? de la asistencia ligada al desempleo. Los resultados que aquí desarrollamos forman parte de una investigación mayor que, desde un enfoque metodológico cualitativo, se plantea como objetivo analizar los modos en que fue reconstruida la relación entre condiciones de vida y delito en las políticas de prevención social del delito, entendiendo a éstas como espacios de intersección entre los campos de la política social y la política criminal. El marco histórico-político que atraviesa estos procesos muestra al clivaje seguridad-inseguridad como uno de los ejes fundamentales a partir de los cuales se organizan ambos campos de políticas aludidos, permeando sus discusiones, sus principios y racionalidades, sus modalidades de intervención. Sostenemos que dicha relación ha sido problematizada en términos de una exterioridad e instrumentalidad de la política social con respecto a las estrategias preventivas, centrada en la idea de contraprestación laboral o de capacitación laboral.","palabras_clave":"Prevención del delito|Contraprestación laboral|Asistencia|Trabajo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1852,"idioma_id":4,"titulo":"Chemometric classification of amaranth by using fatty acid composition","resumen":"In this work, the composition offatty acids was analyzed in order to obtain a chemometric model for theclassification of amaranth varieties seeds: A.cruentus var. Candil (Acc), A.hypochondriacus var. Dorado (Ahd), A.hypochondriacus line H17a (AH17a) and A. cruentus line G6\/17a (AcG6\/17a). Chemometricmodel was performed by linear discriminant analysis (LDA). The results showsthat the discriminant model was able to classify correctly all the studiedvarieties, with 100% of correct classification in all cases, for training andprediction test set. On the other hand, the discriminant functions plot (function1 vs function 2) showed similaritiesbetween A. cruentus var. Candil and A. cruentus line G6\/17a, while A.hypochondriacus var. Dorado and A. hypochondriacus line H17a showed themost important differences with the others ones. As conclusion, LDA inconjunction to fatty acid composition, were able to distinguish betweenvarieties of amaranth, which can be useful as a non expensive method toclassify amaranth seeds.","palabras_clave":"AMARANTH|FATTY ACIDS|CLASSIFICATION|CHEMOMETRIC MODEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1855,"idioma_id":5,"titulo":"Determinación preliminar del potencial de la calidad de la lana de majadas ovinas en la Región Norte de la Provinciade La Pampa","resumen":"ResumenEn general en  la República Argentina se observan constantes introducciones ovinas de diferentes razas y\/o tipos de animales, productores de lana. Algunas zonas del país se caracterizan por poseer poblaciones ovinas estandarizadas, mientras que en otras se ha conservado la heterogeneidad. La región norte de La Pampa no estuvo al margen de dicho proceso, sumado a que no existen antecedentes recientes sobre el tipo de producción de lana de las majadas, y que las leyes de promoción han generado el desarrollo de emprendimientos productivos a partir de la población ovina tradicional, se consideró necesaria la evaluación del recurso genético existente.Se  realizó un estudio con el objetivo de evaluar biológicamente biotipos ovinos en relación a la producción  de lana, con la finalidad de conocer la calidad de la misma en las majadas distribuidas en la región. Durante los años 2011 y 2012 se desarrolló un relevamiento poblacional de 8 majadas del norte de La Pampa, se revisaron en total 1021 ovinos. Se evaluó morfología, conformación, cobertura, fenotipo de color y se tomaron muestras de lana.En forma preliminar se enviaron al laboratorio 400 muestras de lana  que fueron lavadas y clasificadas por criterios de calidad: finura (FM), tipo de vellón (TM) y voluminosidad (BK).En las variables de calidad de lana (FM, TM y BK) y en el tipo de lana (TL), se observaron para las majadas en estudio,  diferencias significativas de proporciones o frecuencias de clases y tipo de lana.Se concluye que las  poblaciones ovinas productoras de lana existentes en el área evaluada son aptas para la confección de alfombras de excelente calidad, constituyendo un gran aporte en la sustentabilidad de los pilares económico, social y ecológico de los sistemas productivos.","palabras_clave":"LANA|COLOR|TIPO DE VELLON|FINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1857,"idioma_id":4,"titulo":"Thermodynamic Analysis of the Thermal Stability of  Sulphonamides in Milk","resumen":"The present study investigates the kinetics of the degradation of eight sulphonamides in skimmed milk when heated at 60, 70, 80, 90 and 100 °C using an LC?MS\/MS methodology. To determine the thermal stability of these compounds, the first-order kinetic model was applied and the activation energies, half-lives and degradation percentages were calculated. Application of kinetic equations to the different heat treatments used in dairy processing indicates that sulphonamides are very stable during pasteurisation (63 °C; 30 min and 72 °C; 15 s) as well as UHT sterilisation (140 °C; 4 s). In contrast, the calculations performed with the kinetic model estimated losses in concentrations between 6.5% (sulfadimethoxine) and 85.1% (sulfamethazine) for the sterilisation at 120 °C for 20 min. The existence of thermodynamic compensation was also tested for sulphonamide degradation. Results show that enthalpy and entropy values displayed a good linear relationship, and thermodynamically we can establish that the thermal degradation of sulphonamides in skimmed milk exhibits enthalpy?entropy compensation.","palabras_clave":"Sulphonamides|Thermal stability|Thermodynamic compensation|First-order kinetic model"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1858,"idioma_id":4,"titulo":"A novel parallelization technique for DEVS simulation of continuous and hybrid systems.","resumen":"In this paper, we introduce a novel parallelization technique for DEVS simulation of continuousand hybrid systems. Here, like in most parallel discrete event simulation methodologies, the models are first split into several sub--models that are concurrently simulated on different processors.In order to avoid the cost of the global synchronization of all processes, the simulation time of each sub--model is locally synchronized in a real--time fashion with a scaled version of physical time, which implicitly synchronizes all sub--models.The new methodology, coined Scaled Real--Time Synchronization (SRTS), does not ensure a perfect synchronization in its implementation. However, under certain conditions, the synchronization error introduced only provokes bounded numerical errors in the simulation results.SRTS uses the same physical time--scaling parameter during the entire simulation. We also developed an adaptive version of the methodology lue{(Adaptive-SRTS)} where this parameter automatically evolves during the simulation according to the workload.We implemented the SRTS and Adaptive-SRTS techniques in pd, a DEVS simulation tool, under the lue{Real Time Operating System} (RTOS) RTAI lue{(RealTime Application Interface)}. We also tested its performance in the simulation of three large models, obtaining in all cases a considerable speedup.","palabras_clave":"parallel simulation|real-time systems|discrete event systems|QSS|hybrid systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1859,"idioma_id":5,"titulo":"Complejidad sintáctica y discurso académico: parámetros gramaticales en la producción escrita de estudiantes universitarios","resumen":"El presente estudio analiza la complejidad sintáctica de textos producidos por estudiantes universitarios que pertenecen a cursos académicos diferentes. Los denominados índices de madurez sintáctica permiten establecer cómo determinado discurso es más o menos complejo desde el punto de vista de su sintaxis, en la medida en que es posible dar cuenta de la capacidad del sujeto que escribe para producir estructuras oracionales consolidadas. El objetivo es, pues, evaluar tales índices, en textos expositivo argumentativos, producidos por estudiantes de 2do y 5to año, que cursan carreras de idiomas en la Facultad de Lenguas de la UNC (Argentina). Con este fin, se considera un corpus conformado por fragmentos discursivos correspondientes a proyectos de investigación diseñados por alumnos de asignaturas introductorias a las tareas de investigación. Se describen los parámetros de complejidad y desarrollo sintáctico en un nivel descriptivo de investigación, desde un enfoque cuantitativo. Se concluye que el promedio de cláusulas por unidad terminal así como la intensidad de incrustación (frente a otros índices) marcan diferencias significativas entre los sujetos de ambos grupos, en cuanto a la competencia gramatical para escribir discursos académicos.","palabras_clave":"ESCRITURA|UNIVERSIDAD|COMPLEJIDAD|SINTÁCTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1860,"idioma_id":5,"titulo":"Modificaciones en el vínculo entre partidos y movimientos en la Argentina de comienzos del siglo XXI","resumen":"El propósito de este trabajo reside en describir el conjunto de transformaciones que ha experimentado el vínculo entre partidos políticos y movimientos sociales en la Argentina democrática. El principal argumento consiste en que la modificación de este vínculo debe interpretarse en dos sentidos. El primero remite al intento de reconstruir el lazo entre Partido Peronista y sindicalismo peronista por parte del kirchnerismo, en tanto fuerza dominante del peronismo. Y, el segundo debe leerse en términos de ampliación del vínculo, el que ya no puede restringirse al peronismo, incorporándose a su análisis a los partidos de izquierda y las organizaciones piqueteras. A nuestro parecer este último elemento constituye un aporte al análisis del vínculo entre partidos y movimientos, con el que se pretende ensanchar sus márgenes. Finalmente, se destaca que para la recolección de la información se ha acudido a las técnicas de la entrevista en profundidad y la observación de documentos.","palabras_clave":"PARTIDOS POLÍTICOS|MOVIMIENTOS SOCIALES|ESTADO|SINDICATOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1861,"idioma_id":4,"titulo":"Failure analysis of a GFRP pipe for oil transport","resumen":"The study was conducted on a pipe sample of GFRP. There was widespread damage in the internal structure of the tube. The &#64258;ow area was blocked due to landslides helical &#64257;bers. The matrix was an epoxy?anhydride system (Diglycidyl Ether of Bisphenol A). There was an advanced state of diffusive processes that reduced the glass transition temperature  (T) of the material to critical levels. The material showed a major irreversible hydrolytic attack. The mechanical behavior would indicate a considerable degree of structural compromise. The sample showed an advanced state of degradation, with clear signals of processes  activated at temperatures close to Tg and catalyzed by the diffusion of low molecular weight organic species. The irreversible chemical degradation process especially attacked the &#64257;ber?matrix interface reducing the mechanical performance.","palabras_clave":"GFRP|Pipeline|Oil transport|Filament winding"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1862,"idioma_id":4,"titulo":"Validation of theory with experiments for local mass transfer at parallel plate electrodes under laminar flow conditions","resumen":"Theoretical equations are reported to calculate the local Sherwood number for a parallel plate electrochemical reactor with a developing flow region under laminar flow conditions. These equations were deduced from analytical velocity profiles according to different proposals, which are compared with the velocity profiles given by the numerical solution of the Navier-Stokes equations. A comparison between the theoretical mass transfer equations with experimental results is also given.                               ","palabras_clave":"DEVELOPING LAMINAR FLOW|FLOW REACTORS|MASS-TRANSFER COEFFICIENT|NON-IDEAL BEHAVIOUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1863,"idioma_id":4,"titulo":"Environmental variability of Macaronichnus ichnofabrics in Eocene tidal-embayment deposits of southern Patagonia, Argentina","resumen":"The Middle Eocene Man Aike Formation of southern Patagonia, Argentina, offers the opportunity to study the palaeoecological and palaeoenvironmental significance of Macaronichnus ichnofabrics in a tide-dominated, coastal embayment compound-dune complex. Four recurrent Macaronichnus ichnofabrics are recognized: Macaronichnus IF-1 characterized by Macaronichnus segregatis segregatis; Macaronichnus IF-2 with M. segregatis segregatis, Ophiomorpha nodosa, Skolithos linearis and rare Palaeophycus tubularis; Macaronichnus IF-3 typified by M. segregatis segregatis, O. nodosa, Asterosoma radiciforme and rare S. linearis; and Macaronichnus IF-4 consisting of M. segregatis segregatis, Nereites missouriensis, A. radiciforme, O. nodosa, Rosselia socialis, S. linearis,  P. tubularis, Planolites isp. and Chondrites isp. Variations in these ichnofabrics are linked to changes in local hydraulic conditions in the upper and lower trough areas of the compound dunes. In high-energy, shallow and marginal marine environments, the Macaronichnus tracemaker is commonly the first to colonize the shifting, sandy substrates. Overprinting by other ichnoguilds occurs only after the physiochemical conditions became favourable and the colonization window length increases.","palabras_clave":"Eocene|Ichnofabrics|Macaronichnus|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1864,"idioma_id":5,"titulo":"Tensiones y disputas entre migrantes africanos recientes y organismos de control estatal. El caso de los senegaleses en la ciudad de La Plata","resumen":"En este trabajo pretendemos, por un lado, describir las prácticas racistas operadas a partir dela lógica de la hipervisibilización de un grupo de migrantes africanos (específicamentesenegaleses), por parte de organizamos de control estatal como la policía bonaerense yagentes municipales de la ciudad de La Plata; y por otro, analizar cómo estas prácticasimpactan en los circuitos migratorios, en la conformación de las redes de migrantes y en lasmodalidades de articulación entre los mismos senegaleses.","palabras_clave":"MIGRACION|SENEGALESES|CONTROL ESTATAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1865,"idioma_id":5,"titulo":"Catolicismo, política e historiografía en la Argentina de entreguerras. Reflexiones a partir de una experiencia de investigación: los casos de Santa Fe y Rosario.","resumen":"El trabajo ensaya una reflexión sobre los procesos de producción de conocimiento en el  campo de la historiografía política, tomando como punto de partida mi propia  investigación doctoral sobre el catolicismo y la política de masas en la Santa  Fe de entreguerras. No se presenta un estado de la cuestión ni una indagación  teórica sobre el problema sino, más bien, un relato del itinerario seguido por  la investigación en el que se explican cómo se fueron construyendo y deconstruyendo algunas de las hipótesis y explicaciones, y qué rol jugaron en el proceso los modelos interpretativos  dominantes, las rutinas académicas y el momento de la escritura, así como los  tiempos de producción marcados por sucesivas becas de posgrado.","palabras_clave":"CATOLICISMO INTEGRAL|HISTORIOGRAFÍA POLÍTICA|PARTIDOS CATÓLICOS|ARGENTINA CATÓLICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1867,"idioma_id":5,"titulo":"EVALUACION CLÍNICA, BIOQUÍMICA Y HEMATOLÓGICA DE CANINOS SEROPOSITIVOS A DISTINTOS SEROVARES DE LEPTOSPIRA interrogans","resumen":"La leptospirosis es una zoonosis de distribución mundial que afecta a diferentes especies animales. La principal fuente de infección es la contaminación del medio ambiente con orina de los animales infectados. En caninos y en el hombre el diagnóstico es dificultoso debido a la variada signología clínica que presenta. El objetivo de este estudio fue evaluar las alteraciones clínicas, bioquímicas y hematológicas más frecuentes en caninos seropositivos a diferentes serovares de Leptospira interrogans. Se estudiaron 44 caninos con signos clínicos compatibles y serología positiva y 25 caninos clínicamente sanos y seronegativos. Se realizó una evaluación clínica completa y se obtuvieron muestras de sangre con y sin anticoagulante, para realizar diagnóstico serológico, hematológico y valorar la función hepática y renal, mediante la determinación de fosfatasa alcalina, alanina aminotransferasa, aspartato aminotransferasa, uremia y creatinemia. Los resultados obtenidos mostraron un alto porcentaje de sueros que coaglutinaron y diferencias significativas en el recuento de glóbulos rojos y blancos y en las variables utilizadas para evaluar función hepática y renal. Los signos clínicos más comunes fueron decaimiento, anorexia, vómitos y dolor abdominal. La utilización de diferentes técnicas favorece el diagnóstico precoz y permite instaurar el tratamiento adecuado, mejorar el pronóstico y colaborar en la prevención.","palabras_clave":"BIOQUIMICA|CANINOS|SEROPOSITIVOS|LEPTOSPIRA INTERROGANS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1868,"idioma_id":5,"titulo":"'General, si usted me permite, yo le voy a fabricar automóviles en el país'. Un nuevo abordaje sobre la producción automotriz en la Argentina (1946-1952)","resumen":"En marzo de 1952 el gobierno argentino creó, sobre la base de las capacidades instaladas en el Instituto Aerotécnico, la empresa Industrias Aeronáuticas y Mecánicas del Estado (IAME). Sus objetivos eran, por un lado, la investigación, fabricación y reparación de material aeronáutico, por el otro, la fundación de una industria automotriz integrada localmente. Para el gobierno peronista, IAME era parte de una estrategia para la promoción de una industria autopartista privada. A nivel estructural, el proyecto del Estado implicó la creación de legislación sectorial a través del desarrollo del Banco Industrial. A nivel empresarial, IAME se encargó de la capacitación laboral y el asesoramiento técnico para la creación y fomento a pequeños y medianos establecimientos metalúrgicos en el área metropolitana de Córdoba, Rosario y Buenos Aires. IAME fue la primera empresa en fabricar automotores en serie en América Latina. En sus instalaciones se diseñaron y produjeron automóviles particulares, utilitarios, motocicletas y tractores, que dieron lugar a la generación de un nuevo sector productivo. Este trabajo tiene por objeto explicar las estrategias estatales de fomento e integración de la industria privada local. A través del empleo de conceptos tales como modelo de acumulación, funcionamiento y estilo socio-técnico, en este artículo se analiza de qué manera un conjunto de elementos heterogéneos (regulaciones sectoriales, capital público, propaganda estatal, empresas privadas, funcionarios, obreros y usuarios, entre otros) se integraron en un proceso de cambio socio-tecno-económico.","palabras_clave":"Industria Automotriz|innovación tecnológica|Peronismo|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1869,"idioma_id":4,"titulo":"FUZZY SETS APPLICATION TO HEALTHCARE SYSTEMS","resumen":"      Abstract      The fuzzy set concept was introduced by Lotfi A. Zadeh  in 1965 to provide a tool to describe vague predicates or classes with  imprecise boundaries and which enable an uncertainty non-additive calculation,  based on soft operators.       Zadeh recognises that conventional quantitative  techniques of systems analysis are intrinsically inappropriate to address  humanistic systems.      The medical field is appropriate to apply the fuzzy  set theory, as vague predicates and subjectivity are an important part of it.       In this paper, the fuzzy set concept is used to provide  a more flexible definition of certain parameters which state an individual?s  health condition, and which will allow to formulate a diagnosis model for the  risk of suffering a certain disease, and it is characterized as a case of  cardiovascular risk.       This model is applied to the development of an  expansion strategy for a private health insurance company, which considers  sustainability of the healthcare system.  ","palabras_clave":"FUZZY SETS|HEALTH PARAMETERS|HEALTHCARE SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1870,"idioma_id":5,"titulo":"Construyendo oficio: experiencias laborales de integrantes de una Planta Social de Separación en el CEAMSE","resumen":"  \t&amp;amp;amp;amp;amp;amp;lt;!--  \t\t@page { margin: 2cm }  \t\tP.sdfootnote { margin-left: 0.5cm; text-indent: -0.5cm; margin-bottom: 0cm; font-size: 10pt }  \t\tP { margin-bottom: 0.21cm }  \t\tA.sdfootnoteanc { font-size: 57% }  \t--&amp;amp;amp;amp;amp;amp;gt;  \t              La  recuperación y clasificación de residuos ha sido considerada como  una expresión acabada del trabajo 'informal' y 'precario'.  Depender de la 'basura' es visto como el último recurso de  aquellas personas situadas en los propios márgenes de 'lo social'.  Estas experiencias, son generalmente caracterizadas como imagen  invertida del 'trabajo formal'.            En  este trabajo presentamos resultados preliminares de un análisis  realizado sobre entrevistas a integrantes de una organización  comunitaria del Gran Buenos Aires. Estas personas que se abastecían  ingresando al basural, son actualmente las encargadas de la gestión  de una de las plantas de clasificación y separación   habilitadas dentro del relleno1.            Sostenemos  la necesidad de recuperar los sentidos que estas personas conjugan  para definir sus prácticas laborales, suspendiendo nociones  preconstruidas como trabajo informal, precario, e indecente. Como evidencian los testimonios analizados, los  integrantes de este colectivo construyen estos sentidos en analogía  con aquellos que configuran el mundo del trabajo formal.  Particularmente, nuestro análisis destaca el modo en el cual estas  prácticas de recuperación y clasificación de residuos adquieren la  forma de un nuevo oficio.            Nuestros  datos señalan la necesidad de repensar en las etiquetas que circulan  en el mundo del trabajo y que inciden en la configuración de  políticas y programas; advirtiendo que bajo formulaciones recientes  acerca de la erradicación de estas prácticas se esconden intentos  por desactivar iniciativas que disputan el monopolio del sistema de  gestión residuos que actualmente detentan las empresas privadas de  recolección y el CEAMSE.              \t            1El  \tpresente trabajo se enmarca en el Proyecto de Investigación  \tPlurianual\/CONICET Lidiando con  \tla solidaridad y el mercado. Un estudio etnográfico de  \temprendimientos y encadenamientos productivos de la ´economía  \tsolidaria´ en Argentina, donde  \tanalizamos experiencias de organización comunitaria vinculadas  \ttanto a la recuperación y reciclado de residuos, como a la  \tcomercialización en redes de comercio justo. Aquí  \tfocalizamos en el análisis de una experiencia perteneciente al  \tprimer grupo, cuyo trabajo de campo de campo fue coordinado por la  \tDra. Cecilia Cross (co-directora del proyecto) a quien agradecemos  \tpor los sustantivos aportes realizados al presente artículo.","palabras_clave":"TRABAJO INFORMAL|RECOLECCION Y CLASIFICACION DE RESIDUOS|CEAMSE|NUEVO OFICIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1871,"idioma_id":4,"titulo":"Matrix Isolation of the Elusive Fluorocarbonylsulfenyl Fluoride Molecule FC(O)SF","resumen":"The syn and anti conformers of the hitherto unknown  fluorocarbonylsulphenyl fluoride, FC(O)SF, were formed through the  photochemical reactions between OCS and F2 , isolated in solid Ar. The reactions  were followed by FTIR spectroscopy, and the unknown products were detected by  comparison the observed IR absorptions with their computed IR spectra. The  reactions occur through a 1:1 molecular complex between OCS and F2 , forming the  anti-FC(O)SF first, which subsequently transforms into the syn form, through a  randomization process. At longer times of irradiation FC(O)SF decomposes by  extrusion of a CO molecule with the concomitant formation of SF2 , and the  formation of difluorophosgene molecule, O=CF2 . The migration of fluorine atoms  in the matrixes is proposed to explain the formation of SF4 , and also SF6 , at longer  irradiation times.","palabras_clave":"Química|Fisicoquímica|Espectroscopia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1872,"idioma_id":5,"titulo":"Equipamiento de laboratorio de bajo costo: ?Tubo de Rubens?","resumen":"El Tubo de Rubens es un dispositivo que posibilita realizar experiencias de acústica en ámbitos educativos.  Con ellas se puede modelizar al sonido como un producto de variaciones de presión que se transmiten en  un medio material y poner en evidencia las perturbaciones mecánicas del espacio durante la manifestación  de distintos sonidos.  En este trabajo se describe la construcción del equipo utilizando insumos de bajo costo. Se detallan cuestiones  referidas a los materiales a emplear y los cuidados necesarios a tener en cuenta durante su fabricación.  Se describen también los fundamentos físicos de su funcionamiento y algunos posibles usos del instrumento  didáctico.","palabras_clave":"Sonido|Ondas sonoras|Ondas estacionarias|Equipo de la laboratorio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1873,"idioma_id":4,"titulo":"The effect of Clostridium perfringens type C strain CN3685 and its isogenic beta toxin null mutant in goats.","resumen":"Clostridium perfringens type C is an important cause of enteritis and\/or enterocolitis in several  animal species, including pigs, sheep, goats, horses and humans. The disease is a classic  enterotoxemia and the enteric lesions and associated systemic effects are thought to be caused  primarily by beta toxin (CPB), one of two typing toxins produced by C. perfringens type C. This  has been demonstrated recently by fulfilling molecular Koch?s postulates in rabbits and mice. We  present here an experimental study to fulfill these postulates in goats, a natural host of C.  perfringens type C disease. Nine healthy male or female Anglo Nubian goat kids were inoculated  with the virulent C. perfringens type C wild-type strain CN3685, an isogenic CPB null mutant or a  strain where the cpb null mutation had been reversed. Three goats inoculated with the wild-type  strain presented abdominal pain, hemorrhagic diarrhea, necrotizing enterocolitis, pulmonary  edema, hydropericardium and death within 24 h of inoculation. Two goats inoculated with the  CPB null mutant and two goats inoculated with sterile culture media (negative controls) remained  clinically healthy during 24 h after inoculation and no gross or histological abnormalities were  observed in the tissues of any of them. Reversal of the null mutation to partially restore CPB  production also increased virulence; 2 goats inoculated with this reversed mutant presented  clinical and pathological changes similar to those observed in goats inoculated with the wild-type  strain, except that spontaneous death was not observed. These results indicate that CPB is required  for C. perfringens type C to induce disease in goats, supporting a key role for this toxin in natural  C. perfringens type C disease pathogenesis.  ©","palabras_clave":"Clostridium perfringens|Enterotoxemia|Goats"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1874,"idioma_id":4,"titulo":"ON APPROXIMATION OF MEASURES OF MAXIMAL ENTROPY FOR DERIVED FROM ANOSOV ENDOMORPHISMS","resumen":"We analyze LD","palabras_clave":"Large deviations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1875,"idioma_id":4,"titulo":"Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus","resumen":"A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.","palabras_clave":"Pseudocnus  dubiosus leoninus|sulphated triterpene glycoside|Antiproliferative|Cytotoxic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1876,"idioma_id":5,"titulo":"Aspectos claves del Federalismo fiscal y las asimetrías regionales en la república Argentina","resumen":"En el presente trabajo se hace un abordaje crítico ? propositivo y estructural (constitución, ley de coparticipación, pactos fiscales y determinadas transferencias condicionadas) del sistema de distribución fiscal argentino (federalismo fiscal) con relación a la prestación efectiva de los servicios públicos básicos (indispensables) para la vida digna de los habitantes en todo el territorio del país, siendo elementos importantes de análisis la generación de capacidades endógenas regionales  adecuadas, la infraestructura y la calidad ? cantidad de la oferta de servicio en relación a la demanda o necesidades poblacionales. Es un estudio de tinte cualitativo, no experimental, cuyos instrumentos de análisis lo constituyen los datos actuales que publica el Instituto Nacional de Estadísticas y Censos (INDEC) referentes a la prestación, cantidad y calidad de servicios públicos en las distintas regiones del país, el último censo nacional del 2010, la legislación histórica y actual referente al Federalismo Fiscal Argentino y la doctrina especializada en este aspecto.","palabras_clave":"Servicios Públicos|Pactos Fiscales|Federalismo Fiscal|Asimetrías"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1877,"idioma_id":4,"titulo":"Spectral evidence of Paleozoic structure in the western Precordillera, San Juan (31°15?S), Argentina.","resumen":"The western Precordillera (Baldis et al., 1982) is located in the western central region of Argentina (Fig.  1). Geologically, it is characterized by the development of an Andean thin- skinned fold and thrust belt  (Cristallini and Ramos 2000), where the internal structure of each thrust sheet shows evidence of several  overlapping deformational phases (von Gosen, 1992; 1995). The stratigraphy of the western Precordillera  in the area is represented by slope and deep marine siliciclastic facies (Don Polo, Alcaparrosa,  Calingasta and El Codo formations) (Quartino et al., 1971). These units are covered unconformably by  both continental and marine neopaleozoic deposits (El Ratón and El Salto formations, respectively). The  stratigraphic succession culminates with volcanosedimentary Triassic units (Barredo and Ramos, 2010) and Cenozoic continental units.","palabras_clave":"Imágenes|Precordillera|estructuras"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1878,"idioma_id":5,"titulo":"Verificación de calidad botánica de pimentones producidos y\/o comercializados en la Quebrada de Humahuaca, Jujuy","resumen":"VERIFICACIÓN DE CALIDAD BOTÁNICA DE PIMENTONES PRODUCIDOS Y\/O COMERCIALIZADOS EN LA QUEBRADA DE HUMAHUACA, JUJUYEstela Noemí Flores, Nilda Dora Vignale y Alberto Ángel GurniRESUMENEn la Quebrada de Humahuaca circulan alimentos en redes de comercializacióninformales, donde se hace importante desde el punto de vista bromatológicoconocer la genuinidad de estos productos alimenticios. Se analizaron productosdeshidratados que se producen y\/o comercializan en la región, específicamente?pimentón?, producto derivado de Capsicum annuumsegún el C.A.A., para verificarsu calidad botánica utilizando el método micrográfico. Se reconocieron previamente los patrones micrográficos de la especie en frutos de pimiento, los cuales ya están establecidos en la bibliografía. Estos se aplicaron en muestras de pimentón, en donde se usó una muestra genuina como testigo adquirida en S. S. de Jujuy, la cual junto a la producida por una cooperativa local evidenciaron claramente los caracteres micrográficos diagnósticos, verificándose su calidad botánica, por lo cual se puede afirmar que su materia prima corresponde a C. annuum. El resto de las muestras adquiridas en mercados y ferias de la región, a pesar de que revelaban algunos elementos diagnósticos, mostraron la presencia de granos de almidón, dando la prueba del Lugol positiva por lo cual no se garantiza su genuinidad y por lo tanto no se recomiendan para el consumo humano.","palabras_clave":"calidad botánica|Capsicum annuum|micrografía|pimentón"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1879,"idioma_id":5,"titulo":"LOS ESPACIOS DE OCIO DE LA CIUDAD DE BAHÍA BLANCA","resumen":"El presente trabajo analizala oferta recreativa de los espacios con finalidad de ocio de la ciudad deBahía Blanca. Para ello, se rescata la visión de los habitantes en relación ala valorización que asignan a distintos espacios de ocio a escala local y seanaliza la relevancia otorgada en los diversos planes de ordenamiento urbano yproyectos formulados en la ciudad.&nbsp;El análisis destaca una distribucióndesequilibrada de la oferta recreativa y la pérdida de espacios públicos en lazona costera, siendo en la actualidad los de menor preferencia de la población.A su vez, los espacios privados han incrementado su participación, los cuales,asociados a nuevas pautas culturales y de consumo, encuentran condicionespropicias para su desarrollo.","palabras_clave":"ESPACIOS DE OCIO|TIEMPO LIBRE|ESPACIO PÚBLICO|BAHÍA BLANCA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1882,"idioma_id":4,"titulo":"Karyotypes in species of Eryngium in Argentina.","resumen":"The objetive of this study is to analyse the karyotype to determine the chromosomal asymmetry and its relationships with the evolution of species of Eryngium.","palabras_clave":"assymetry|evolution|Eryngium|karyotype"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1883,"idioma_id":5,"titulo":"Paradigmas de Estado en Brasil según Amado Cervo. Una perspectiva desde el Sur Global","resumen":"Este artículo analiza la importancia de estudiar la historia, la configuración y rol que ha tenido el Estado en Brasil. El concepto de paradigma de Estado, el cual implica un profundo análisis de la forma que adopta la economía y la sociedad con sus intereses, el patrón de inserción internacional y la formación nacional de cada etapa, es una herramienta propuesta desde el pensamiento del Sur por parte del internacionalista brasileño Amado Cervo, la cual permite analizar la interacción entre los factores internacionales y los condicionantes domésticos. Este autor propone cuatro paradigmas de Estado: el liberal conservador, el desarrollista, el normal y el logístico. Se concluye sobre las características distintivas de la estrategia de Brasil en orden a su inserción internacional y a su modelo de desarrollo desde el año 2002 a la  actualidad.","palabras_clave":"ESTADO |BRASIL |INTERNACIONAL |DESARROLLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1884,"idioma_id":5,"titulo":"Estudio Exploratorio de las Características Psicométricas del Portrait Values Questionnaire en el contexto de Córdoba\/Argentina.","resumen":"El estudio analizó algunas propiedades psicométricas del Portrait Values   Questionnaire, instrumento de medición de valores humanos en su versión   de 21 ítems (Schwartz & Rubel-Lifschitz, 2009), en una muestra no   aleatoria de 419 ciudadanos cordobeses (Argentina), con una media de   edad de 34.81 y una desviación típica de 10.16. Para evaluar la   evidencia de estructura y de consistencia interna se realizó un análisis   factorial exploratorio y se estimó el coeficiente alfa de Cronbach,   respectivamente. Los resultados indican que el instrumento presenta   buenos niveles de confiabilidad en las tres dimensiones: conservación,   apertura al cambio y autopromoción (&#945;=.68 a &#945;=.71). Sin embargo, la estructura teórica propuesta por el autor se ratifica parcialmente.","palabras_clave":"VALORES SOCIALES|PORTRAIT VALUES QUESTIONNAIRE|SHWARTZ|PSICOLOGÍA SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1885,"idioma_id":5,"titulo":"Diversidad de Araneae (Arachnida) en la Reserva Colonia Benitez, Chaco Oriental Húmedo, Argentina.","resumen":"Se estudióla diversidad y composición del ensamble de arañas de la Reserva Educativa Colonia Benítez, Chaco, Argentina.Las técnicas de captura incluyeron trampas de caída, golpeteo de follaje, tamizado de hojarasca, captura manual nocturna y aspiración de la vegetación mediante el uso de G-vac. El período de muestreo abarcó octubre, noviembre y diciembre de 2011. Los resultados describen la diversidad detectada (familias, especies y morfoespecies), preferencia de ambientes, eficiencia de métodos de captura, índices de riqueza específica, diversidad y abundancia. Un total de 1527 arañas fueron recolectadas, representantes de 27 familias, 179 especies y morfoespecies.Las familias más diversas fueron Araneidae, Lycosidae, Salticidae y Anyphaenidae. La mayor abundancia se registró en el bosque (59%)donde se identificaron 21 familias, seis de ellas se encontraron solo en este ambiente (Deinopidae, Mimetidae, Selenopidae, Senoculidae, Sparassidae y Uloboridae). En el pastizal se recolectaron 629 individuos (41%) agrupados también en 21 familias, seis de ellas no encontradas en el Bosque (Amphinectidae, Dictynidae, Oxyopidae, Pholcidae, Scytodidae y Trechaleidae). Las técnicas G-Vac en el pastizal y golpeteo de follaje en el bosque demostraron ser muy efectivas para el muestreo de la diversidad de arañas.","palabras_clave":"BIODIVERSIDAD|ARANEAE|ARAÑAS|AREAS PROTEGIDAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1886,"idioma_id":5,"titulo":"Hacia la reconstrucción de un perfil de juez\/a permeables a las demandas de identidad de género: el caso del contencioso administrativo tributario de la Ciudad de Buenos Aires","resumen":"Las nuevas demandas de igualdad, en particular aquellas que nos ocupan  en este trabajo, no sólo constituyen una estrategia de reconocimiento por  parte de los actores que las llevan adelante, sino que también implican -en la reciprocidad intrínseca a toda demanda de estas características- una interpelación a los operadores jurídicos, y en particular a los jueces. En otras palabras,al optar por reconocer -o no- los reclamos, los jueces no sólo definen al ciudadano\/a sino también, y fundamentalmente, se ven obligados a definirse a sí mismos haciendo relevante la pregunta por los perfiles de jueces ?deseados? y ?reales?. En esta línea, el presente trabajo se propone reconstruir los perfiles de aquellos jueces del fuero Contencioso Administrativo y Tributario de la Ciudad Autónoma de Buenos Aires con el fin de elucidar un proceso de cambio en la organización judicial local y así como también para determinar el  impacto de éste sobre un tipo específico de demandas de igualdad.","palabras_clave":"igualdad|identidad de género|perfil de jueces\/zas|permeabilidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1887,"idioma_id":4,"titulo":"Ichnology of the Late Carboniferous Hoyada Verde Formation of western Argentina: Exploring postglacial shallow-marine ecosystems of Gondwana","resumen":"The postglacial interval of the Upper Carboniferous Hoyada Verde Formation of western Argentina contains anichnofauna dominated by Psammichnites plummeri and Psammichnites implexus, with minor occurrences ofPtychoplasma vagans, Treptichnus bifurcus, Lingulichnus verticalis, Protovirgularia isp., Lockeia isp., Palaeophycusisp., scarce arthropod trackways and some bilobate structures. The particular features of this association indicatea depauperate expression of the Cruziana Ichnofacies, and suggest a context that differs fromthe expected in normalshallow-marine settings (i.e. archetypal Cruziana Ichnofacies). Integration of sedimentologic, ichnologic,sequence-stratigraphic and paleontologic data points to a prograding deltaic system influenced by wave action.Trace fossils have been extensively used to recognize stressed brackish-water environments in the late Paleozoicof Gondwana. However, the recognition of stressed settings needs to take into consideration the specific paleogeographiccontext of glacially influenced Gondwanan settings. A postglacial open sea adjacent to apaleotopographic high is considered as a possible scenario for the Hoyada Verde Formation. In this particular setting,coastal biotas could have been influenced to some degree by the salinity gradient triggered by freshwater releasenear to melting ice masses stored in highlands and also by freshwater plumes due to longshore currents.Regional factors (e.g. proximity to highlands and climate) may have played an important role in controlling thecharacteristics of Gondwanan ichnofaunas. This suggests that the distinction between normal-marine andbrackish-water settings in glacially influenced environments using trace fossils may not be as straightforwardas in non-glacial settings.","palabras_clave":"Ichnology|Ichnofacies|Glacial|Carboniferous"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1889,"idioma_id":5,"titulo":"El campesinado de traslasierra de la provincia de Córdoba y sus vinculaciones socio-territoriales","resumen":"La finalidad de esta presentación es volcar los resultados obtenidos sobre las diversas problemáticas socio-territoriales que afectan al campesinado -y por extensión a pequeños productores- de Traslasierra de la provincia de Córdoba. El espacio en cuestión involucra a cuatro departamentos, o sea a todo el flanco occidental de la provincia.El sujeto social que nos interesa, fuertemente ligado al espacio que habita, se caracteriza por mostrar una economía de subsistencia y por la utilización plena de mano de obra familiar. En suma, entendemos que el campesino es básicamente un minifundista con limitados recursos económicos, cuya tierra se encuentra, muchas veces, en situación de tenencia precaria. El objetivo central que perseguimos consiste en estudiar de manera integral el estado de situación general del campesinado de referencia y las conflictividades político-económicas por las que atraviesa. La metodología de investigación consiste en un trabajo básicamente empírico, abordada como estudio de caso, trabajo de campo con entrevistas semiestructuradas.","palabras_clave":"PROBLEMATICAS SOCIOTERRITORIALES|CAMPESINO|OESTE CORDOBES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1890,"idioma_id":5,"titulo":"Las Ciencias Naturales en el Nivel Inicial","resumen":"Frente a la incorporación de tecnología informática en varias escuelas de la región, surge la necesidad de incorporar las TIC en las propuestas de enseñanza de formación docente y también incluir estas herramientas en el diseño de estrategias didácticas que permitan a los niños a aprender de manera diferente en nuevos contextos.  Se analiza la producción de un grupo de futuros docentes que incorporan las TIC como recurso didáctico y la incidencia de la propuesta en la enseñanza del concepto de cambio químico.","palabras_clave":"Ciencias Naturales|Enseñanza de las Ciencias |Nivel Inicial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1891,"idioma_id":5,"titulo":": ?La experiencia puesta en relatos: encuentros entre vida, enseñanza y literatura?","resumen":"Una serie de reflexiones en torno a las posibilidades hermenéuticas surgidas de los avances en investigación biográfico-narrativa en educación, permitió enfocar en el campo específico de la enseñanza literaria, sus actores y sus vidas puestas en relato. El interés suscitado por la coincidencia del material de trabajo en uno y otro caso, favoreció la profundización del análisis de las categorías propuestas por esta línea de estudios y su abordaje desde perspectivas que incorporaron la dimensión textual del relato en el desentrañamiento de sentidos configurados en él. Así, las voces de dos docentes de Letras puestas a funcionar en la narración de sus vidas, su vínculo con las instituciones educativas, con los alumnos y con la enseñanza de la literatura, articularon un discurso que permitió extraer material para un análisis interpretativo y, al mismo tiempo, identificar la dimensión que asume la literatura cuando se hace vida.","palabras_clave":"LITERATURA|ENSEÑANZA|BIOGRAFÍA|NARRACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1892,"idioma_id":4,"titulo":"ANALYSIS OF DENTAL HOMOLOGIES AND PHYLOGENY OF PAUCITUBERCULATA (MAMMALIA: MARSUPIALIA)","resumen":"The Paucituberculata is an endemic group of South American marsupials, recorded from the early Cenozoic up to the present. In this report, the most comprehensive phylogenetic analysis of Paucituberculata to date is presented. Fifty-seven terminal species were scored for 74 new and re-examined characters. Homologies of dental characters used in previous systematic studies were critically reviewed to evaluate their inclusion in the analysis. Phylogenetic results corroborated two major paucituberculatan clades, Palaeothentoidea and Caenolestoidea, and the main palaeothentoid groupings: Pichipilidae, Palaeothentidae, and Abderitidae. Taxon sampling and reinterpretations of molar cusp and crest homologies played an important role in the generation of new phylogenetic hypotheses. The main differences with respect to previous phylogenies were focused on palaeothentoid relationships: Palaeothentes boliviensis and Pilchenia lucina are not members of Palaeothentidae but instead clustered with Pilchenia intermedia and P. antiqua, forming the sister-group of a Palaeothentidae + Abderitidae clade, and Titanothentes  simpsoni, previously considered a palaeothentine, is nested within the Acdestinae clade. Based on the timecalibrated phylogeny, the following stages in the paucituberculatan evolutionary history are suggested: origin of the group, in the Paleocene to early Eocene at the latest, split of Caenolestoidea and Palaeothentoidea clades during the late early to middle Eocene, evolutionary radiation of palaeothentid and abderitid lineages near the Oligocene?Eocene boundary, and decreased diversity and extinction of palaeothentoids during the middle Miocene.","palabras_clave":"ABDERITIDAE|PALAEOTHENTIDAE|CAENOLESTIDAE|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1893,"idioma_id":5,"titulo":"¿Como hacer un satelite espacial a partir de un reactor nuclear? Elogio de las tecnologias de investigacion en INVAP","resumen":"Este artículo plantea un análisis posible del proceso de generación y desarrollo de Tecnologías de Investigación (TIs) en INVAP. Puede considerarse la cartera extremadamente diversificada de productos de INVAP como justamente el resultado de procesos continuos de desarrollo de tecnología. Las TIs antes referidas dan cuenta de un saber intersticial ? a veces, también inter-departamental ? circulante que ha cruzado, cuando menos, las fronteras de una disciplina académica específica. De acuerdo con esta perspectiva teórica, el quehacer en I+D tecnológico de una organización puede caracterizarse como un proceso coordinado, transversal, inter-departamental e inter-disciplinario. Las TIs poseen la capacidad de ser desensambladas de un proyecto de desarrollo determinado y ser, luego, re-ensambladas dentro de otro\/s proyecto\/s de desarrollo o área\/s organizacional\/es de actividad tecnológica. En este artículo se identifican y describen las dinámicas históricas de seis TIs de INVAP. La perspectiva de TI, por un lado, le quita relevancia al énfasis tradicional atinente a la generación de nuevos productos o la mejora de procesos productivos que enfáticamente prohíja la literatura más convencional de I+D. Además, esta perspectiva destaca la importancia de monitorear la evolución de distintas TIs a nivel organizacional para que puedan contribuir a conformar capacidades dinámicas organizacionales a su debido tiempo. ","palabras_clave":"Tecnologías de Investigación |Gestión de I+D |Capacidades Dinámicas |Organizaciones de Base Tecnológica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1894,"idioma_id":5,"titulo":"Importancia del seguimiento de los alumnos ingresantes mediante el encuentro grupal con el tutor","resumen":"Importancia delseguimiento de los alumnos ingresantes mediante el encuentro grupal con el tutor.","palabras_clave":"ALUMNOS|INGRESANTES|ENCUENTRO|TUTOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1896,"idioma_id":4,"titulo":"Art in Action","resumen":"Artistic expressions are generally judged mainly by experts in the art field through an array of perspectives which sometimes may wrongly lead us to the belief that art is beyond our reach. But what if we could have our own students judging art-related aspects in our very context? Colours are present when appreciating and creating artwork and by incorporating artistic representations from varied genres in our practice, we can bring them into our classroom to liven up our lessons. Then, we will have a rainbow at arm?s reach, ready to be discovered. This article explores the pedagogical potential of different visual representations and their use in the ELT classroom. Art-based materials provide the starting point for the development of creativity and imagination in learners. To cover some practical aspects, a worksheet with tasks that draw on students? senses and emotions will be shared.","palabras_clave":"ARTE|ENSEÑANZA DE LENGUAS EXTRANJERAS|MOTIVACION|CREATIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1897,"idioma_id":5,"titulo":"\u201CPasaje al acto, acting out y acto analítico. Variaciones de la relación sujeto-Otro II\u201D","resumen":"  \t&amp;lt;!--  \t\t@page { margin: 0.79in }  \t\tP { margin-bottom: 0.08in; direction: ltr; color: #000000; widows: 2; orphans: 2 }  \t\tP.western { font-family: 'Times New Roman', serif; font-size: 12pt; so-language: es-ES }  \t\tP.cjk { font-family: 'Times New Roman', serif; font-size: 12pt; so-language: zh-CN }  \t\tP.ctl { font-family: 'Times New Roman', serif; font-size: 12pt; so-language: ar-SA }  \t\tA:link { color: #0000ff }  \t--&amp;gt;  \t    Eneste artículose presentanlos vectoresprincipales ylos avancesdel proyectode investigación2010-2012: \u201CTransformacionesdelconceptodepasajealactoenelperíododelaobradeJ.Lacancomprendidoentre1963y1980.Similitudesydiferenciasconlosconceptosdeactoyactingout\u201D.  Con el objetivo de avanzar en la  precisión de la génesis, delimitación y transformaciones del  concepto de pasaje al acto en la enseñanza de Lacan, indagamos aquí:  1) A partir del caso de psicosis de Lol V. Stein, al acting-out como  una vicisitud transferencial, que pone a jugar lo que ha quedado  suspendido, 2) Las coordenadas del pasaje al acto y del acto  analítico teniendo como eje al Sujeto y su constitución en tanto  resto de la escena parental, 3) Los aportes de los conceptos de  pasaje al acto y acto, en relación  al acto creativo, tomando como  ejemplo la biografía de Nijinski y 4) Las diferencias entre pasaje  al acto y acto, que nos permiten sostener al pasaje al acto  como un  concepto que conserva a lo largo del pensamiento lacaniano un valor  clínico transestructural que el concepto de acto no diluye.  ","palabras_clave":"pasaje al acto|acting out|acto analítico|acto creativo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1898,"idioma_id":4,"titulo":"Synthesis, characterization and applications of amphiphilic elastomeric polyurethane networks in drug delivery","resumen":"Polyurethanes have a key role in the development of many different biomedical devices because of their exceptional biocompatibility, mechanical properties and versatility. Although linear segmented polyurethanes have been extensively studied, the investigation of cross-linked polyurethanes remains limited. In this work, three series of polyurethane networks were synthesized by reacting poly(ethylene glycol) and hexamethylene diisocyanate with either tetrafunctional poloxamer Tetronic 701 or poly(e-caprolactone)s triol with molecular weights of 1060 and 3130 Da. The hydrophilic\/hydrophobic ratio was varied by selecting the appropriate amounts of monomers, and its effects on the swelling behavior and the thermal properties were analyzed. Studies concerning the release of a model drug were performed, the results of which indicate that these materialshold promise for use in controlled implantable drug-delivery devices and antimicrobial coatings.","palabras_clave":"controlled drug release|hydrophilic\/hydrophobic ratio|polyurethane networks|swelling behavior|thermal properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1899,"idioma_id":5,"titulo":"Cultura cooperativa y gestión empresarial en la cuenca lechera cordobesa-santafecina. Argentina, fines del s. XIX a 1970.","resumen":"Resumen: Este artículo presenta resultados de una investigación basada en fuentes primarias. Revaloriza el conocimiento de procesos históricos espacial y temporalmente particularizados. Apunta a explicar las transformaciones históricas que tenían lugar en la cuenca lechera cordobesa-santafecina en Argentina cuando se intensificaba la actividad agroindustrial bajo el liderazgo de la empresa cooperativa Sancor (Fábrica de manteca Sancor Cooperativas limitadas).  Abstract:  This article presents results of an investigation based on primary sources. Revalues the historical process knowledge particularized space and time. It aims to explain the historical changes taking place in Cordoba- Santa Fe dairy area in Argentina when agroindustrial activity intensified under the leadership of the cooperative enterprise Sancor (Sancor Butter Factory Co Limited).","palabras_clave":"CUENCA|LECHERA|CULTURA|EMPRESAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1901,"idioma_id":5,"titulo":"Estudio Morfométrico del Nervio Óptico de Tiburoncito (Ariopsis seemanni)","resumen":"En peces, el nervio óptico es el encargado de transportar la información integrada por las células ganglionares de la retina hacia el tectum óptico, para que se generen imágenes acerca del entorno. El objetivo de este trabajo es describir morfométricamente el nervio óptico del tiburoncito (Ariopsis seemanni), para lo cual se utilizó la Microscopía óptica de Alta Resolución (MOAR), realizan- do cortes a 1 micra de espesor. El nervio óptico de A. seemanni presenta fibras mielínicas de diverso calibre, acompañadas de oligodendrocitos y astrocitos. El nervio está cubierto por las meninges, que presentan vasos sanguíneos y adipocitos. El nervio tiene un área total de 179604 ± 30163 &#956;m2, diámetro de 478 ± 42 &#956;m y un número total de fibras mielínicas de 22848 ± 4350, de las cuales la mayoría tiene un tamaño pequeño, que puede estar relacionado con una velocidad de conducción baja.","palabras_clave":"TIBURONCITO|ARIOPSIS SEEMANNI|NERVIO OPTICO|FIBRAS NERVIOSAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1902,"idioma_id":4,"titulo":"Task Rescheduling using Relational Reinforcement Learning","resumen":"Generating and representing knowledge about heuristics for repair-based scheduling is a key issue in any rescheduling strategy to deal with unforeseen events and disturbances. Resorting to a feature-based propositional representation of schedule states is very inefficient and generalization to unseen states is highly unreliable whereas knowledge transfer to similar scheduling domains is difficult. In contrast, first-order relational representations enable the exploitation of the existence of domain objects and relations over these objects, and enable the use of  quantification over objectives (goals), action effects and properties of states. In this work, a novel approach which formalizes the re-scheduling problem as a Relational Markov Decision Process integrating first-order (deictic)representations of (abstract) schedule states is presented. Task rescheduling is solved using a relational reinforcement learning algorithm implemented in a real-time prototype system which makes room for an interactive scheduling strategy that successfully handle different repair goals and disruption scenarios. An industrial case study vividly shows how relational abstractions provide compact repair policies with minor computational efforts.","palabras_clave":"RESCHEDULING|RELATIONAL REINFORCEMENT LEARNING|MANUFACTURING CONTROL|RELATIONAL ABSTRACTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1903,"idioma_id":5,"titulo":"Transmisión entre generaciones: potencialidades y limitaciones de la historia de familia como herramienta metodológica","resumen":"El presente trabajo se enmarca en el Proyecto de Investigación ?Entre generaciones:memorias y procesos de formación en barrios de Tolosa y Meridiano V de La Plata: años`50, `70 y ´90 y se propone indagar y reflexionar acerca de la reconstrucción de lashistorias de vida y de familia a lo largo de tres generaciones a fin de establecer laspotencialidades y limitaciones de dicha herramienta metodológica a la hora de indagarsobre procesos de formación\/ transmisión entre generaciones y su ineludible papel en larecuperación de la memoria colectiva.La","palabras_clave":"Transmisión|historias de familia|metodología"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1905,"idioma_id":4,"titulo":"Neotyphodium fungal endophyte in tall fescue (Schedonorus phoenix): a comparison of three Northern European wild populations and the cultivar Kentuky-31","resumen":"Pooideae grasses may be colonized by systemic fungal endophytes. The fitness of endophyte depends entirely on resources and seed transmission from the host plant, while colonized plants may gain increased survival, growth, and reproduction relative to their uncolonized conspecifics. Most research of endophyte-grass interactions have been carried out on few cultivars of tall fescue (Schedonorus phoenix) and their symbiont Neotyphodium coenophialum. Lack of studies using wild populations of tall fescue across the species natural distribution range, however, limits the understanding of the ecological and evolutionary role of the symbiosis in nature. We performed a common garden experiment in Southern Finland with three wild, tall fescue populations from northern Europe and the forage cultivar Kentucky-31 (KY-31). For each population, we used naturally endophyte-colonized, naturally endophyte colonized but endophyte removed (decolonized), and naturally uncolonized plants to separate effects due to the host genotype from the endophyte. We evaluated growth variables and survival in four environmental treatments of varying water and nutrients. Supply of water and nutrients increased plant biomass and reproductive effort in all populations. This effect was higher for KY-31 plants which produced on average 55 % more seeds than wild plants, indicating better adaptation to high resource environments. However, the higher incidence of Claviceps sp. and the low winter survival indicated KY-31 tall fescue is mal-adapted to Northern European conditions. Naturally colonized plants had greater plant biomass (&#8776;12 %), reproductive effort (&#8776;22 %) and seed mass (&#8776;29 %) than naturally uncolonized and decolonized plants. Nonetheless, endophyte colonization did not affect plant survival, and the effects of endophyte colonization on tiller number, panicle\/tiller ratio and Claviceps sp. incidence depended on the population origin. In the wild populations, endophyte removal only reduced the number of tillers (&#8776;29 % lower), while the difference between naturally colonized and naturally uncolonized plants was not significant. Our results show that endophyte symbiont increases tall fescue performance in general, but the differences between wild populations and cultivars indicate adaptation to local habitats and agronomic management, respectively. The comparison of naturally endophyte-colonized and decolonized plants suggests certain plant genotype-endophyte combinations found within populations result from local selection pressures.&nbsp;","palabras_clave":"Plant-microbial symbiosis|Vertically transmitted symbiont|Symbiosis|Claviceps"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1906,"idioma_id":4,"titulo":"Partial characterization of enzymatic activities produced by a wild strain of A. niger","resumen":"Aspergillus niger, isolated from decay citrus peels in the province of Misiones, was able to produce pectinases by submerged fermentation. The enzymatic extract exhibited polygalacturonase, pectinesterase and lyase activities. Others enzymes capable of degrading cell wall polymers were also detected in the enzymatic extract such as cellulases and xylanases. Polygalacturonase was an endo-polygalacturonase. The enzyme exhibited a maximal activity at pH range between 4.5 to 5.0, was stable in the pH range from 2.5 to 5.5 and remained unchanged when was incubated at temperatures lower than 50 ºC. The fungi produced three PG isoenzymes. The enzymatic extract was able to clarify apple juice. The results observed make the pectinolytic enzymes produced by A. niger appropriate for future application in fruit juice processing industries.","palabras_clave":"Aspergillus niger|pecinolytic enzymes|polygalacturonase"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1907,"idioma_id":5,"titulo":"'Pasión por enseñar. Emociones y afectos de profesores universitarios memorables'","resumen":"Este trabajo retoma investigaciones que, desde el año 2003, lleva adelante el Grupo de Investigaciones en Educación y Estudios Culturales de la Facultad de Humanidades, Universidad Nacional de Mar del Plata, Argentina. El objetivo de este escrito es el de presentar algunos de esos resultados en el campo de la Formación del Profesorado y, más específicamente la Didáctica de la Educación Superior a la vez que, compartir los primeros aportes centrados en la categoría Pasión por la enseñanza. Las lecturas que realizaremos surgen de las entrevistas biográfico-narrativas a seis docentes seleccionados como memorables por sus estudiantes y del grupo focal realizado con cuatro de ellos, todos docentes de la Facultad de Humanidades de la Universidad Nacional de Mar del Plata de las carreras de Letras, Filosofía y Geografía. ","palabras_clave":"DIDÁCTICA|EDUCACIÓN SUPERIOR|PROFESORES MEMORABLES|PASIÓN POR LA ENSEÑANZA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1908,"idioma_id":5,"titulo":"LA ESTRUCTURA DE OPORTUNIDAD POLÍTICA COMO OBSTÁCULO AL DESARROLLO DE LA REGIÓN CENTRO DE LA REPÚBLICA ARGENTINA","resumen":"Frente  a los análisis más usuales, de cuño dominantemente economicista, el presente  texto privilegia la 'estructura de de oportunidad política' para el análisis de  la Región Centro  de la República Argentina.  Esta perspectiva analítica permite advertir  cómo factores del sistema político  obstaculizan el éxito de la acción colectiva cooperativa, necesaria para la  construcción de la región subnacional y conduce a sostener plausiblemente que  las diferencias político-partidarias y la explotación oportunista de los  recursos financieros y políticos se encuentran en el núcleo del pobre desempeño  regional hasta la fecha. Para ello, y luego de realizar algunas precisiones teóricas  y conceptuales, se describe la formación regional bajo análisis, su contexto y  su dinámica manifestada en las estrategias de actores institucionales  centrales.","palabras_clave":"REGION INTERPROVINCIAL|ESTRUCTURA DE OPORTUNIDAD POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1909,"idioma_id":4,"titulo":"A high burnup model developed for the DIONISIO code","resumen":"A group of subroutines, designed to extend the application range of the fuel performance code DIONISIOto high burn up, has recently been included in the code. The new calculation tools, which are tuned forUO2 fuels in LWR conditions, predict the radial distribution of power density, burnup, and concentration of diverse nuclides within the pellet. The balance equations of all the isotopes involved in the fission processare solved in a simplified manner, and the one-group effective cross sections of all of them areobtained as functions of the radial position in the pellet, burnup, and enrichment in 235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.of diverse nuclides within the pellet. The balance equations of all the isotopes involved in the fission processare solved in a simplified manner, and the one-group effective cross sections of all of them areobtained as functions of the radial position in the pellet, burnup, and enrichment in 235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.of diverse nuclides within the pellet. The balance equations of all the isotopes involved in the fission processare solved in a simplified manner, and the one-group effective cross sections of all of them areobtained as functions of the radial position in the pellet, burnup, and enrichment in 235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.2 fuels in LWR conditions, predict the radial distribution of power density, burnup, and concentration of diverse nuclides within the pellet. The balance equations of all the isotopes involved in the fission processare solved in a simplified manner, and the one-group effective cross sections of all of them areobtained as functions of the radial position in the pellet, burnup, and enrichment in 235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIOare presented. The good agreement with the data provided in the FUMEX II\/III NEA data bank can be easilyrecognized.","palabras_clave":"NUCLEAR FUEL|HIGH BURNUP|CROSS SECTION|NEUTRON SPECTRUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1911,"idioma_id":4,"titulo":"Dominance of the planktonic diatom Thalassiosira minima in  recent summers in the Bahía Blanca Estuary, Argentina","resumen":"The diatom Thalassiosira minima, was firstly recorded in the Bahía Blanca Estuary in 1992., In 1992-93, it exhibited a broad seasonal occurrence during the first years (1992-1993). A recent survey (2006-2007) however showed a seasonal appearance restricted mainly to summer along together with a larger greater relative abundance within the phytoplankton. A close connection was found with warmer, saltier more saline and highly turbid conditions experienced in recent summers in the estuary. Whether these changes will impact the estuary trophic dynamics remains an open question.","palabras_clave":"Ecologia estuarial|Fitoplancton|Florecimientos anuales|Sucesion ecologica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1912,"idioma_id":5,"titulo":"COMUNICACION EN LA PLANIFICACION Y GESTION PARA EL DESARROLLO DE LAS INSTITUCIONES UNIVERSITARIAS PUBLICAS ARGENTINAS II","resumen":"COMUNICACION EN LA PLANIFICACION Y GESTION","palabras_clave":"PLANIFICACION DEL DESARROLLO INSTITUCIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1913,"idioma_id":5,"titulo":"Una discusión con el concepto de 'des industrialización' desde el caso del noreste de Chubut","resumen":"El concepto de 'des industrialización' ha sido dominante como esquema para pensar los cambios que ha sufrido la economía argentina desde alrededor de 1976 hasta el comienzo del siglo XXI. En este artículo debatimos con el uso de esta perspectiva, rastreando los orígenes y presupuestos inscriptos en esa mirada, a partir del estudio de los trabajos de diversos autores, y desarrollando una mirada diferente como eje para comprender el proceso que se da en la región noreste de Chubut en los últimos años del siglo XX y los primeros del XXI. Centralmente discutimos con la idea de la 'des industrialización' de la estructura económica, que, en conjunto con la retracción del Estado, la falta de regulaciones a la economía y la 'desintegración' nacional, son los ejes de la interpretación clásica acerca de los cambios que se habrían producido en Argentina desde el dominio del capital financiero. Se propone la imprescindible necesidad de repensar la utilización de estos conceptos, para trabajarlos desde una perspectiva sistémica, destacando la importancia de romper con las idealizaciones que rodean al concepto de industria y\/o de industrialización en Argentina.","palabras_clave":"INDUSTRIA|DESINDUSTRIALIZACIÓN|ESTRUCTURA ECONÓMICA|ESTADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1914,"idioma_id":4,"titulo":"On Extracting Probability Distribution Information from Time Series","resumen":"Time-series (TS) are employed in a variety of academic disciplines. In this  paper we focus on extracting probability density functions (PDFs) from TS to gain an  insight into the underlying dynamic processes. On discussing this ?extraction? problem,  we consider two popular approaches that we identify as histograms and Bandt?Pompe. We  use an information-theoretic method to objectively compare the information content of the  concomitant PDFs.","palabras_clave":"BandtPompe;| histograms;| time-series"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1915,"idioma_id":5,"titulo":"APLICACIÓN DE AGROQUÍMICOS Y DELITO DE CONTAMINACIÓN DOLOSA DEL AMBIENTE DE UN MODO PELIGROSO PARA LA SALUD: EL CASO 'ITUZAINGÓ ANEXO'","resumen":"FALLO ANOTADO: 'Gabrielli Jorge Alberto y otros p.s.a. Infracción Ley 24.051', Cámara en lo Criminal de Primera Nominación de la Ciudad de Córdoba, Secretaría Nº 2, 4 de septiembre de 2012.Sumario: Emergencia sanitaria. Fumigaciones. Residuos peligrosos. Contaminación ambiental por deriva de agroquímicos en el grado de instigador y autor. Contaminación dolosa del ambiente de un modo peligroso para la salud. Delito de ejecución continuada y concurso material.","palabras_clave":"DERECHO PENAL AMBIENTAL|AGROQUÍMICOS|FUMIGACIONES|CONTAMINACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1916,"idioma_id":4,"titulo":"DETERMINING FACTORS IN PROCESS OF SOCIO-TECHNICAL ADEQUACY OF RENEWABLE ENERGY IN ANDEAN COMMUNITIES OF SALTA, ARGENTINA","resumen":"The use of renewable energy presents a great potential to solve energy problems in remote communities. However, in populations of the northwestern of Argentina, there are a large number of abandoned devices. This situation motivated the research on the processes of ?technology transfer?, in order to make theoretical and methodological contributions to help to improve them. The development of this work was based on the analysis of case studies in the Andean communities of Cabrerías, San Juan and Las Capillas (Province of Salta, Argentina) where solar water heaters were ?transferred?. The main results presented in this paper are the identification, assessment and analysis of factors and sub-factors that conditions the analyzed processes. There were identified the following determining factors: solar technology, community participation, involvement of technicians, inter-institutional coordination, logistics and monitoring of the project, and structure of the community. The analysis of interaction showed a strong interdependence among factors, in this manner; the way in which a factor is applied directly influences the development of other factors. Finally, it should be noted that although the analyzed experiences have much in common, each situation of socio-technical adequacy is particula and therefore it requires the opening-up of researchers and technicians to adapt technologies and methodological approaches of these processes.","palabras_clave":"Solar |Energy|Rural communiies applications"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1917,"idioma_id":5,"titulo":"Desarrollo de competencias comunicativas en la formación del ingeniero: una propuesta interdisciplinaria","resumen":"La inserción en la comunidad profesional exigeciertas destrezas comunicativas. Cotidianamente,el ingeniero utiliza el lenguaje como herramienta ensituaciones comunicativas orales, escritas o mixtas enlas que interactúa con otros y realiza transaccionesque requieren competencias comunicativas para transmitirinformación, dar órdenes, negociar, orientar,comunicar decisiones, consultar, producir conocimiento,controlar actividades o conductas, gestionar información.En este contexto, necesita dominar un complejorepertorio de géneros, por lo que su enseñanzaresulta fundamental en la instancia de formación universitaria.Aquí, presentamos resultados parciales deuna investigación interdisciplinaria sobre los génerosprofesionales del ámbito empresarial realizada poringenieros y lingüistas. Específicamente, nos concentramosen el género procedimiento operativo estandarizado.Los resultados obtenidos señalan que la característicamás sobresaliente de este género es la decontribuir al sistema de calidad de la empresa, lo quees retomado desde la propuesta de enseñanza parapropiciar el desarrollo de competencias comunicativasen nuestros estudiantes.","palabras_clave":"COMPETENCIAS |INGENIERÍA|COMUNICACIÓN|INTERDISCIPLINARIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1918,"idioma_id":4,"titulo":"Fish passage system in an irrigation dam (Pilcomayo River basin): When engineering designs do not match ecohydraulic criteria.","resumen":"The Route 28 Dam has the potential to block fish movements from La Estrella marsh to the Pilcomayo River. In addition, the many fish that concentrate immediately downstream of the dam may suffer high mortality when they are stranded during low water periods. The goals of this study are to determine if fish are able to pass the spillway and to assess if the design of the installed ladders (pool and weir type) effectively supports upstream migration of Prochilodus lineatus (sábalo). Results showed that only fish longer than 39 cm should be able to ascend the spillway chute, but when water levels on the spillway crest are over 0.4 m. Fish are also unable to jump from spillway toe to spillway crest because the downstream dissipation pool does not meet the minimum depth criterion for fish to accelerate to sufficient velocity. Fish ladders have insufficient number of pools and some pool dimensions and designs depart from accepted standard designs. Volumetric dissipation power in the upper pool of each fish ladder is too low for fish to rest. Also, attraction flows relative to total spillway discharge at the entrance to each fishway are insufficient. Fish passage failures of both the spillway and pool and weir systems in La Estrella marsh can be traced to the 'salmon-centric' concept used by the designers. We conclude that the Route 28 Dam design including its fish passage systems, do not follow criteria to cope with the strong hydrological variability and bioecological characteristics of fish inhabiting pulsatile systems such as La Estrella marsh.","palabras_clave":"Dam spillway|La Estrella marsh|Pilcomayo basin|Fish passage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1921,"idioma_id":5,"titulo":"Jóvenes y políticas educativas en un contexto de reconstrucción de horizontes colectivos","resumen":"El presente trabajo presenta reflexiones y avances de una investigaciónrecientemente iniciada, que tiene por objeto analizar las construcciones de sentido y lasperspectivas sobre los jóvenes que producen y sustentan programas vigentes de políticaeducativa pública orientados a éstos; así como los modos en que buscan reconfigurar lasprácticas de formación, los vínculos jóvenes-adultos y las relaciones con el conocimiento en un nuevo contexto histórico-social.El interés se sitúa en la identificación de la emergencia, en los últimos años de ladécada que nos precede, de una serie de políticas que intentan modificar los dispositivos institucionalizados con el fin de promover transformaciones de los procesos deformación de los jóvenes al interior de los espacios educativos, que estarían atendiendotanto a definiciones político-filosóficas sobre el papel de la educación en la sociedad,como así también a las nuevas configuraciones subjetivas juveniles y a sus prácticasculturales contemporáneas.","palabras_clave":"jovenes|transformaciones culturales|politicas educativas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1922,"idioma_id":5,"titulo":"El oficio del etnógrafo: una metáfora de género","resumen":"Se trabaja el problema del dualismo sujeto-objeto para arribar a una definición provisional disolutiva y no instrumental de sujeto investigador y con ello de etnógrafo. Como se parte de la base de que en sentido estricto el sujeto no puede ser representado, la propuesta del concepto alternativo para definirlo que se ofrece en este ensayo, es apenas una proposición metafórica con fines deconstructivos.","palabras_clave":"Etnografía|Investigador|Objeto de estudio|Etnógrafo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1923,"idioma_id":5,"titulo":"Cerdos para los muchos: neodeterminismo y representaciones étnicas precarias en ecología política","resumen":"Se discute sobre la necesidad de integrar la etnoecología y la ecología política para abordar algunos temas tratados actualmente por la antropología ecológica. La discusión se plantea sobre la base de un testimonio que desde la cosmogonía guaraní aborda los problemas ambientales y territoriales, destacando una crisis de liderazgo indígena como elemento desencadenante del deterioro biocultural. La narrativa en cuestión puede considerarse un caso específico de ?mitología de la privación?.","palabras_clave":"Guaraníes|Ecología|Mitología|Privación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1925,"idioma_id":5,"titulo":"Aportes para el  trabajo en el aula. Un enfoque para determinar la forma de vida de los moluscos bivalvos a partir de la morfología de sus valvas.","resumen":"En&nbsp; este&nbsp; trabajo&nbsp; se&nbsp; presenta&nbsp; una&nbsp; actividad&nbsp; práctica&nbsp; de&nbsp; integración&nbsp; de&nbsp; contenidos relativos&nbsp; a&nbsp; la&nbsp; biología&nbsp; animal.&nbsp; Constituye&nbsp; un&nbsp; abordaje&nbsp; para&nbsp; el&nbsp; estudio&nbsp; de&nbsp; las adaptaciones&nbsp; a&nbsp; la&nbsp; forma&nbsp; de&nbsp; vida&nbsp; de&nbsp; los&nbsp; moluscos&nbsp; bivalvos,&nbsp; enfocado&nbsp; a&nbsp; partir&nbsp; del análisis&nbsp; de&nbsp; la&nbsp; morfología&nbsp; de&nbsp; sus&nbsp; valvas.&nbsp; Se&nbsp; pretende&nbsp; que,&nbsp; sobre&nbsp; la&nbsp; base&nbsp; del reconocimiento&nbsp; de&nbsp; la&nbsp; morfología&nbsp; de&nbsp; la&nbsp; conchilla&nbsp; y&nbsp; las&nbsp; marcas&nbsp; musculares&nbsp; de&nbsp; la misma, se determine la forma de vida y las adaptaciones al hábitat de ejemplares representativos&nbsp; de&nbsp; este&nbsp; grupo.&nbsp; El&nbsp; esquema&nbsp; que&nbsp; aquí&nbsp; se&nbsp; propone&nbsp; y&nbsp; ejemplifica&nbsp; es adecuado&nbsp; para&nbsp; explorar&nbsp; la&nbsp; riqueza&nbsp; que&nbsp; ofrece&nbsp; el&nbsp; estudio&nbsp; de&nbsp; la&nbsp; biología&nbsp; de&nbsp; los invertebrados,&nbsp; ya&nbsp; que&nbsp; favorece&nbsp; la&nbsp; construcción&nbsp; de&nbsp; conocimiento&nbsp; a&nbsp; partir&nbsp; de&nbsp; la confrontación con una situación-problema.","palabras_clave":"Educación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1926,"idioma_id":5,"titulo":"?Vestigios de un pasado doliente. Los archivos audiovisuales sobre la dictadura militar en el cine documental argentino?","resumen":"&nbsp;El presente artículo examina la función que los archivos audiovisuales han tenido en las representaciones documentales desde el ocaso del gobierno de facto hasta nuestros días, deteniéndose en el análisis de algunos films que plantean rupturas y continuidades respecto a los modos tradicionales de inscribir los registros del pasado en sus narraciones. La idea de base que atraviesa este trabajo es que si bien se observa una expansión gradual del repertorio de imágenes y sonidos de archivo en las películas no ficcionales de las últimas décadas, las funciones discursivas que los realizadores privilegian se han mantenido relativamente estables. Un recorrido por el documental argentino demostrará precisamente que en contadas ocasiones se formulan preguntas a los materiales audiovisuales, ya que se los suele utilizar con funciones probatorias, indiciales, ilustrativas o evocativas, con el objetivo de sostener una interpretación del pasado que preexiste a la construcción fílmica. ","palabras_clave":"DOCUMENTAL |CINE ARGENTINO|ARCHIVO FÍLMICO|MEMORIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1929,"idioma_id":5,"titulo":"Los mercados de trabajo locales desde una perspectiva relacional y su vínculo con las políticas de formación y empleo. El caso de la vitivinicultura mendocina.","resumen":"Este artículo es resultado de una línea de investigación referida al mercado de trabajo y al análisis de las fuentes de información disponibles para su medición. Particularmente, se circunscribe al análisis del mercado de trabajo asociado a la actividad vitivinícola en la Provincia de Mendoza, Argentina. El concepto de mercado al que se adscribe es relacional y está directamente vinculado con el de territorio y configuración socioproductiva; comprende entonces la dinámica de todos los actores involucrados a distintos niveles (regional, provincial, nacional, internacional) en una determinada actividad económica, con sus recursos y relaciones, no circunscribiéndose al tradicional análisis de la oferta y la demanda.   En estudios anteriores hemos evidenciado que la información disponible respecto de los mercados de trabajo es parcial e insuficiente para reflejar su heterogeneidad y complejidad; motivo por el cual el presente artículo busca ser un aporte a la discusión en torno a ello, así como a la centralidad que adquieren las políticas públicas destinadas a la formación y al empleo de los trabajadores como eje del desarrollo territorial local.","palabras_clave":"MERCADOS DE TRABAJO LOCALES|JOVENES|VITIVINICULTURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1931,"idioma_id":5,"titulo":"El cuerpo múltiple qom en un universo superpoblado","resumen":"En este trabajo reflexionaremos sobre las nociones de cuerpo y persona a partir de nuestra etnografía entre los qom del Gran Chaco, en diálogo con diversos rasgos que hacen al cuerpo y a la persona en otras sociedades indígenas. Partimos del carácter colectivo del cuerpo y de su no-naturalidad para detenernos en los seres que son concebidos como personas. Luego, abordamos la importancia de la agencia no-humana en la formación de los cuerpos humanos. Finalmente, ahondamos en la permeabilidad de los cuerpos y en la interconexión posible entre ellos gracias a la circulación de emociones.","palabras_clave":"cuerpo|persona|gran chaco|animismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1932,"idioma_id":4,"titulo":"Tame italian ryegrass (Lolium multiflorum L) enchancement in the argentine flooding pampa","resumen":"ABSTRACT.  Effective operation of grazing production systems needs control the production of forage at farm level. A nine year old stand of enhanced tame native ryegrass (Lolium multiflorum  L.) (RGE) and an annual crop of Italian ryegrass (Lolium multiflorum L. cv Tama) (RGT) were monitored to test the hypothesis that: (i) herbage biomass in such pastures can be assessed by Ration Calculation methodology as accurately as by more exhaustive procedures, and  (ii) enhancement increases amount and quality of forage winter supply. Enhancement includes fertilization with NH4NO3 and (NH4)2HPO4,   and weed control with Glyphosate (N- (phosphonomethyl glycine)).  The Ration Calculation method estimates available herbage dry matter assuming that ?one herbage ration? equal to one cow equivalent (CE), consisting of 10 kg DM day-1 with 77.57 MJ of ME. Herbage samples were taken from each paddock, representing harvestable biomass. Grazing harvest efficiency and herbage DM intake (HDMI) were estimated through difference between initial (IHA) and final (FHA) herbage available (kg DM ha-1), before and after grazing, corrected by losses due to grazing. Eight grazing cycles of  RGE produced 16 041 kg DM\/ha year-1, (2 001 ± 79.3 rations\/ha year-1) while ration calculation estimates 9 775 kg DM\/ha year-1. The RGT allowed seven grazing cycles, yielded 12 269 kg DM\/ha year-1 or 1 144 ± 87.1 rations\/ha year-1 compared to 8 688 kg DM\/ha year-1 estimated by calculating ration. The ration calculation method did not accurately assess the enhanced cumulative herbage DM produced.  Enhancement technology improved production and quality of tame ryegrass in winter time.","palabras_clave":"RANGELANDS ENHANCEMENT|RYEGRASS ENHANCEMENT|RATION CALCULATION|COW EQUIVALENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1934,"idioma_id":5,"titulo":"REGIONALISMO SUDAMERICANO: SUS CARACTERÍSTICAS","resumen":"El trabajo analiza al regionalismo sudamericano en sus características preponderantes a través de los distintos procesos regionales a fin de contribuir al debate sobre una categoría de análisis no consensuada epistemológicamente ni científicamente.","palabras_clave":"Regionalismo|Sudamérica|Características|Debate teórico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1935,"idioma_id":5,"titulo":"Caracterización de thraustoquitridios (Labyrinthulomycetes heterokonta) de zonas del litoral del Golfo San Jorge sometidas a contaminación por hidrocarburos","resumen":"              Los traustoquitridios  son organismos unicelulares de interés actual por su capacidad de producción de  ácidos poliinsaturados omega 3, en particular del ácido docosahexaenoico (DHA,  C22:6, n-3), y por su participación como agentes degradadores de hidrocarburos.  Se realizaron tareas de muestreo de material en descomposición en zonas de la  costa cercana a los puertos de embarque de petróleo de Comodoro Rivadavia y  Caleta Córdova, ubicados en el Golfo San Jorge (Patagonia argentina), comprobándose  la existencia de microorganismos de este orden. Desarrollando las etapas pertinentes  a su aislamiento e identificación se obtuvieron 8 cepas con rasgos morfológicos  diferenciables y empleando diferentes condiciones de cultivo se obtuvieron las  biomasas de 7 de ellas en cantidad suficiente para determinar sus perfiles de  ácidos grasos de modo de contar con información relevante para su caracterización.  ","palabras_clave":"ácidos grasos|traustoquitridios|Labyrinthulomycetes|Golfo San Jorge"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1936,"idioma_id":5,"titulo":"Contingencia y ambigüedad en los itinerarios \u201Cmestizos\u201D. Análisis histórico sobre las clasificaciones socio-étnicas-raciales en la Catamarca tardocolonial","resumen":"¿Qué modalidades asumieron las categorizaciones socio-étnicas-raciales en la jurisdicción de Catamarca a finales de la colonia? ¿Cuáles fueron los mecanismos que favorecieron el pasaje de una categoría a otra? ¿Cuál fue la movilidad posible y legítima? En esta presentación parto de estas preguntas y de la consideración de que un estudio sobre las identificaciones coloniales requiere de análisis particularizados, es decir, explicados en sus condiciones históricas, entramados sociales y de poder específicos. De la misma manera, que la reducción de la escala de observación resulta indispensable para explorar el funcionamiento de lógicas sociales más generales. Algunos recorridos mestizos reconstruidos a partir de las fuentes eclesiásticas -principalmente- y de otros juicios civiles que se encuentran en el Archivo Histórico de Catamarca, me permitirán en este caso confirmar el carácter contingente de ciertos itinerarios locales y también discutir el esquema estático, pretendidamente fijo y estereotipado acerca de las categorizaciones coloniales.","palabras_clave":"AMBIGUEDAD |CATAMARCA|MESTIZOS|TAXONOMÍAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1937,"idioma_id":4,"titulo":"Water as an appreciated feature in the landscape: a comparison of residents? and visitors? preferences in Buenos Aires,","resumen":"In the Buenos Aires metropolis we analyzed the preferences for water as a landscape feature, interviewingvisitors to waterfronts and residents who live near the river coast in urban and suburban areas.Seven hundred and thirty one questionnaires were completed through personal interviews with visitorsto waterfronts and with coastal residents in April and June 2009. We considered urban and suburbanwaterfronts located in five urban reserves. Respondents were stratified in urban and suburban coastalresidents. In line with the widespread water preferences mentioned in comparable studies, andfollowing evolutionary theories - water as one of the most important elements for life - no genderinfluence on preference could be found.On the contrary we found that individual experiences based on cultural traits, such as familiarity witha place, explained the discrepancy between urban and suburban coastal residents, while surprise andinduced water scarcity account for the differences between visitors to urban and suburban waterfronts","palabras_clave":"Water preferences    |Gender|Scarcity |Familiarity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1938,"idioma_id":4,"titulo":"Characterization of bioactive compound produced by Saccharomyces cerevisiae capable of Patulin degradation","resumen":"Patulin is a mycotoxin produced by Penicillium and Aspergillus species, and in particular by P. expansum in apple-rotting fungus. In this work a bioactive compound produced by Saccharomyces cerevisiae capable of degrading patulin was isolated and characterized. We used the sterile supernatant of the culture of Saccharomyces cerevisiae ultrafiltrate membrane of regenerated cellulose of 10,000 NMWL for retention and concentration of bioactive compound, followed by purification by electrophoresis without denaturation. The toxin was quantified by HPLC reverse phase isocratic system and UV detection at 275nm, with a detection limit of 4.3 &#956;g\/L and quantification of 8.6 &#956;g\/L. The bioactive compound present in the crude extract ultrafiltrate was capable of degrading 3 &#956;g of patulin\/ml initially added to undetectable levels in 32 hours. The molecular weight determined by electrophoresis under denaturing conditions was estimated to be 22.07 kDa and the isoelectric point determined by isoelectric focusing was 3. The pH and temperature of maximum degrading activity were between 4 and 5, 30 and 35°C, respectively. The compound showed no detectable glycosylations by analysis of carbohydrates and the activity failed to produce at a temperature of 80°C for 20 minutes. The bioactive compound showed efficient degradation of patulin and must be tested for toxigenicity and degradation products of patulin so it can be used in the degradation of the toxin from its addition in apple products before or after pasteurization.","palabras_clave":"MYCOTOXIN|DETOXIFICATION|APPLE|PATULIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1939,"idioma_id":4,"titulo":"Abscisic acid and salicylic acid levels induced by different relative humidity and salinity conditions in the halophyte Prosopis strombulifera.","resumen":"It has been shown that abscisic acid (ABA) and salicylic acid (SA) act as endogenous signal molecules responsible for inducing abiotic stress tolerance in plants. However, our knowledge on the role of both phytohormones in response to environmental conditions in halophytic plants is still limited. In this study endogenous ABA and SA levels, growth parameters and chlorophylls content were determined in leaves and roots of the halophyte P. strombulifera cultivated under increasing NaCl and Na2SO4 concentrations, at 30% and 70% relative humidity conditions. Endogenous ABA and SA content differed depending on the salt type and concentration, relative humidity, plant age and the organ analyzed. Under low humidity conditions P. strombulifera showed a strong growth inhibition and a decrease in chlorophyll a and b content. In leaves of Na2SO4-treated plants at 30% RH, high ABA levels were correlated with protection against dehydration and ion toxicity. Instead, high SA levels were correlated with the damaging effect of sulfate anion and low humidity on plant growth. NaCl-treated plants growth was also inhibited at 30% RH although levels of both hormones were not significantly increased. Taken together, the salt toxic effects on growth parameters and photosynthetic pigments were accentuated by low humidity conditions and these responses were reflected on ABA and SA content.","palabras_clave":"ABSCICIC ACID|HALOPHYTES|HUMIDITY CONDITIONS|PLANT GROWTH|SALICILIC ACID|SALINITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1940,"idioma_id":4,"titulo":"Different sodium salts cause different solute accumulation in the halophyte Prosopis strombulifera","resumen":"The success of Prosopis strombulifera in growing under high NaCl concentrations  involves a carefully controlled balance among different processes, including com-  partmentation of Cl) and Na+ in leaf vacuoles, exclusion of Na+ in roots, osmotic  adjustment and low transpiration. In contrast, Na2SO4 causes growth inhibition  and toxicity. We propose that protection of the cytoplasm can be achieved through  production of high endogenous levels of specific compatible solutes. To test our  hypothesis, we examined endogenous levels of compatible solutes in roots and  leaves of 29-, 40- and 48-day-old P. strombulifera plants grown in media containing  various concentrations of NaCl, Na2SO4 or in mixtures of both, with osmotic poten-  tials of )1.0,)1.9 and )2.6 MPa, as correlated with changes in hydric parameters.  At 24 h after the last pulse plants grown in high NaCl concentrations had higher  relative water content and relatively higher osmotic potential than plants grown in  Na2SO4 (at 49 days). These plants also had increased synthesis of proline, pinitol  and mannitol in the cytoplasm, accompanied by normal carbon metabolism. When  the sulphate anion is present in the medium, the capacities for ion compartmentali-  sation and osmotic adjustment are reduced, resulting in water imbalance and symp-  toms of toxicity due to altered carbon metabolism, e.g. synthesis of sorbitol instead  of mannitol, reduced sucrose production and protein content. This inhibition was  partially mitigated when both anions were present together in the solution, demon-  strating a detrimental effect of the sulphate ion on plant growth.","palabras_clave":"AMINO ACIDS|CARBOHIDRATES|NaCl; Na2SO4;|OSMOTIC POTENTIAL|PROTEINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1941,"idioma_id":5,"titulo":"El estar siendo de la UTD  Mosconi. Una aproximación geocultural a la lucha piquetera","resumen":"Elpresente trabajo, tiene como intención ensayar un acercamiento al ?estarsiendo? deUTD&nbsp; Mosconi, desde un horizontegeocultural. Ante todo, siguiendo a Kusch, se trata de des-andary des-hacer las prácticas y lógicas político-culturales de estos hombres ymujeres, quedejando de ser ?ypefianos? se pusieron de pié para la marcha y, desde el?estar? ensayaronun ?para ser?. Esto implica un acercamiento a la situación acontecimental emergente,en la cual les fué posible dar los primeros pasos de danza y, así poder trazar,entreel ?suelo y el símbolo?, el camino germinativo de autoconstituciónre-inventiva, en el entretrágico de la vida y la muerte. Así, UTD es comprendida, como una organizaciónen movimiento,que se instala al modo de una re-vuelta, la cual se torna de-colonial, es decirreveladoray redentora entre y frente de los órdenes y sentidos&nbsp; dispuestos","palabras_clave":"ESTAR|SIMBOLO|SUELO|TRABAJADORES DESOCUPADOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1942,"idioma_id":4,"titulo":"Late Miocene capybaras (Rodentia, Cavioidea, Hydrochoeridae): skull anatomy, taxonomy,  evolution and biochronology","resumen":"Fossil capybaras are morphologically extremely varied, but previous studies have disagreed on   whether this diversity reflects intraspecific variability or the existence of multiple species. Here, we   review the capybaras from the classic Argentinian Late Miocene localities of Paraná River cliffs   (?conglomerado osífero? of the Ituzaingó Formation, Entre Ríos), and Chillhué and Guatraché   shallow lakes (Cerro Azul Formation, La Pampa), and perform a morphometric analysis of their   upper cheek teeth and the posterior portion of the rostrum. Our results confirm that all of the   specimens from the ?conglomerado osífero? belong to the single species Cardiatherium paranense   (Ameghino). In addition, we refer a specimen from Tupungato (Río de los Pozos Formation,   Mendoza) to C. paranense, thus expanding its geographical range. The material from La Pampa   represents a different species, and is here preliminary referred to Cardiatherium aff. orientalis. Our   systematic interpretation of Late Miocene capybaras suggests that the early radiation of this group   was not as explosive as previously thought, and was likely constrained by the early acquisition of   large size, increasing complexity of the cheek teeth, and probably semi-aquatic habits.","palabras_clave":"Rodentia|Hydrochoeridae|Anatomía|Mioceno tardío"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1943,"idioma_id":5,"titulo":"VARIABILIDAD EN LA UTILIZACIÓN DE PIGMENTOS EN ENTIERROS HUMANOS DEL HOLOCENO TARDÍO EN LA CUENCA SUPERIOR DEL RÍO SANTA CRUZ (PATAGONIA ARGENTINA)","resumen":"El objetivo de este trabajo es analizar la existencia de cambios  en la   forma de utilización de pigmentos en dos sitios en los que  se han   realizado entierros múltiples en la cuenca superior del  río Santa Cruz,   a comienzos y finales del Holoceno Tardío. Se  efectuaron análisis   macroscópicos, con microscopio binocular  y de difracción de rayos X.   Los resultados obtenidos sugieren  la existencia de un cambio en la   forma de aplicación de  pigmentos entre ca. 3600 y 420 años AP, lo que   se suma a las  evidencias ya existentes referidas a variaciones en la   selección  de espacios para realizar las inhumaciones y a la utilización    de termoalteración sobre los restos humanos.","palabras_clave":"PATAGONIA|PIGMENTOS|ENTIERROS HUMANOS|HOLOCENO TARDÍO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1944,"idioma_id":5,"titulo":"Explotación de obsidiana negra en la costa norte de Santa Cruz (Patagonia Argentina)","resumen":"En este trabajo se presentan los resultados del análisis de elementos traza realizados a 15 artefactos de obsidiana negra recuperados en la Costa Norte de la provincia de Santa Cruz, particularmente en los sectores Cabo Blanco y Sur de la ría Deseado. Los estudios geoquímicos indican que la totalidad de las piezas analizadas corresponden a los tres tipos químicos identificados en Pampa del Asador. La distancia a la fuente de procedencia varía entre 400 km para el caso de Cabo Blanco y 380 km para el Sur de la ría Deseado. Estos resultados se evalúan en función de algunas tendencias en las densidades y características de los artefactos de obsidiana negra registrados en el área con la finalidad de discutir, de forma preliminar, problemáticas relacionadas con la circulación a grandes distancias, el intercambio y el uso de estas rocas en el pasado.","palabras_clave":"OBSIDIANA|COSTA|SANTA CRUZ|APROVISIONAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1945,"idioma_id":4,"titulo":"Seed bank composition in a secondary forest in the Lower Delta of the Paraná River (Argentina)","resumen":"The native forests once occupying the coastal levees of the Lower Delta islands of the Paraná River (in Argentina) have been replaced by commercial forests. Many of those forests have been abandoned, resulting in secondary forest formation that is subject to numerous invasive exotic species. A priori observations suggest that successional trends do not lead to recovery of the original forest. The aim of the present study was to analyze the role of invasive exotic species in these environments and the likelihood of recovery of the original forest cover. Therefore, we examined the composition of the seed bank and of the standing vegetation, as well as the population structure of tree species. Secondary forests are described as being in an intermediate successional stage, with few exotic species (mainly trees) but with a high abundance of standing vegetation and seed banks. These exotic species will likely continue to successfully predominate in different forest strata over the next stages. Because of the low density of native tree species, it is difficult to predict their future persistence. In conclusion, ecological restoration strategies will be needed in order to increase native tree species richness and biodiversity of the forests in the Lower Delta of the Paraná River.","palabras_clave":"CHINESE PRIVET (LIGUSTRUM SINENSE)|INVASIVE SPECIES|POST-ABANDONMENT REGENERATION|RIPARIAN FOREST"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1946,"idioma_id":5,"titulo":"Los sentidos de la nación y el federalismo en la Argentina (1830-1880)","resumen":"La nación y el federalismo constituyen conceptos claves de la tradición política argentina que adoptaron sentidos cambiantes según el clima de ideas de la época. Durante la segunda mitad del siglo XIX el significado de la nación se equiparó con el de Estado, puesto ambos vocablos aludían a una arquitectura institucional a la que se asignaba una vocación de unificadora. Ahora bien, la discusión sobre las formas que adoptaría la unidad precipitó cuarenta años de discordia en tanto Buenos Aires identificó la unificación con centralización de la que se consideraba beneficiaria natural como capital del virreinato. Por el contrario, las provincias defendieron un esquema federal fundado en la delegación voluntaria de sus atribuciones con el objetivo de constituir un entramado institucional central. Tal propuesta, se cristalizó en la constitución de 1853 que incorporó la noción federal para definir las competencias nacionales y  provinciales de cada cuerpo político  En esa dirección el objetivo de este artículo consiste en analizar los sentidos diversos que adoptó el federalismo argentino entre 1830-1880, en función de la relación de fuerzas cambiantes entre  las provincias y el incipiente Estado central. En tal sentido, el vocablo federal podía aludir al proceso de descomposición del orden colonial, caracterizado por la retroversión de la soberanía a las ciudades  o expresar un movimiento federal con vocación totalizadora y unificadora. Ambas acepciones se articularon de manera virtuosa con los significados de la nación.","palabras_clave":"nación |federalismo|centralización"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1947,"idioma_id":4,"titulo":"Effect of Soy Flour and Whey Protein Concentrate 1 on Cookie Color","resumen":"The objective of this work was to investigate the effect of soy flour and whey  protein concentrate (WPC) addition on the extent of Maillard reaction and  caramelization during cookie baking. Wheat flour from a rotary molded cookie  formulation was partially replaced by full fat soy flour and whey protein concentrate. A  central composite design was used and second order models were employed to generate  response surfaces for loss of available lysine and for color development. Diffuse  reflectance measurement of cookies was used to obtain the k\/s coefficients of the  Kubelka-Munk equation where k is the absorption coefficient and s is the scattering  coefficient at 450, 557 and 680 nanometers. Luminance, dominant wavelength and  excitation purity were also calculated. The addition of WPC produced an important  increase in available lysine loss, k\/s values and excitation purity, and a decrease in  luminance and dominant wavelength. These results indicate that the addition of WPC  favors the development of cookie color probably because of its high lactose content. On  the contrary, the increment of water content produces a delay of Maillard reaction and  caramelization. Soy flour had no significant effect on loss of available lysine and its  effect on color parameter was much less significant than that of WPC.","palabras_clave":"soy flour|whey protein concentrate|available lysine|Maillard reaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1948,"idioma_id":5,"titulo":"La actual Ley de Migraciones de Argentina en la balanza biopolítica","resumen":"Al abordar la actual Ley de Migraciones en Argentina N º 25.871, existe cierto consenso sobre el cambio de enfoque que supuso con relación a la Ley General de Migraciones y Fomento de la Inmigración. La originalidad de la nueva normativa residiría en la ?autolimitación? de la ?razón de Estado? a partir del reconocimiento de las migraciones extranjeras desde el enfoque de derechos humanos. En el artículo propuesto, se entiende que aunque desde la ?razón jurídica? se ha avanzado en garantizar ciertos derechos antes limitados a ?sus ciudadanos?, por otra parte esto puede interpretarse como una continuidad de su ?gubernamentalidad?, susceptibles de leerse en clave biopolítica.","palabras_clave":"FOUCAULT|BIOPOLÍTICA|NORMATIVAS MIGRATORIAS|GUBERNAMENTALIDAD|RAZÒN DE ESTADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1949,"idioma_id":5,"titulo":"'Adscripta a la Señora'. Apuntes y reflexiones sobre los recursos de la polìtica: el PPF","resumen":"Este artículo propone analizar algunos puntos del espinoso tema del financiamiento de la política a partir del análisis de un partido político  creado desde el gobierno y que presentó características singulares. El Partido Peronista Femenino (PPF) se creó luego de tres años del peronismo en el poder y buscó movilizar a las mujeres como sujetos políticos nuevos en la vida partidaria. La historiografía ha dedicado poco espacio al estudio del financiamiento de los partidos en general, y del peronismo en particular. Es probable que el consentimiento extendido de que el gobierno peronista se valió de los recursos del Estado para solventar la política haya obstruido un análisis más preciso sobre los alcances de estas afirmaciones. Estudios previos permiten señalar que una gran matriz de financiamiento fue el Estado; el punto es indagar cuáles fueron las prácticas concretas adoptadas. Ahora, esta aserción &#61485;un tanto amplia&#61485; merece ser disgregada para observar de qué hablamos cuando nos referimos a ?los recursos del Estado?. Este trabajo busca analizar cómo se afrontó el financiamiento para organizar el PPF, y procura desentrañar a partir de qué instrumentos y resortes específicos. También es cierto que el peronista no ha sido el primero ni tampoco el último partido en financiarse con recursos estatales.http:\/\/www.latindex.unam.mx\/buscador\/ficRev.html?folio=19655","palabras_clave":"Partidos POlìticos|Financiamiento|Empleados Publicos|Partido Peronista Femenino"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1950,"idioma_id":4,"titulo":"Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system.","resumen":"Alzheimer's disease (AD) is characterized by progressive, age-dependent degeneration of neurons in the central nervous system. A large body of evidence indicates that neurons affected in AD follow a dying-back pattern of degeneration, where abnormalities in synaptic function and axonal connectivity long precede somatic cell death. Mechanisms underlying dying-back degeneration of neurons in AD remain elusive but several have been proposed, including deficits in fast axonal transport (FAT). Accordingly, genetic evidence linked alterations in FAT to dying-back degeneration of neurons, and FAT defects have been widely documented in various AD models. In light of these findings, we discuss experimental evidence linking several AD-related pathogenic polypeptides to aberrant activation of signaling pathways involved in the phosphoregulation of microtubule-based motor proteins. While each pathway appears to affect FAT in a unique manner, in the context of AD, many of these pathways might work synergistically to compromise the delivery of molecular components critical for the maintenance and function of synapses and axons. Therapeutic approaches aimed at preventing FAT deficits by normalizing the activity of specific protein kinases may help prevent degeneration of vulnerable neurons in AD.","palabras_clave":"axon|degeneration|alzheimer's disease|axonal transport"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1951,"idioma_id":4,"titulo":"Variational Description Of Gibbs-non-Gibbs Dynamical Transitions For The Curie-Weiss Model","resumen":"We perform a detailed study of Gibbs-non-Gibbs transitions for the  Curie-Weiss model subject to independent spin-flip dynamics  ('infinite-temperature' dynamics). We show that, in this setup, the program  outlined in van Enter, Fern´andez, den Hollander and Redig can be fully  completed, namely that Gibbs-non-Gibbs transitions are equivalent to  bifurcations in the set of global minima of the large-deviation rate function  for the trajectories of the magnetization conditioned on their endpoint. As a  consequence, we show that the time-evolved model is non-Gibbs if and only if  this set is not a singleton for some value of the final magnetization. A  detailed description of the possible scenarios of bifurcation is given, leading  to a full characterization of passages from Gibbs to non-Gibbs -and vice versa-  with sharp transition times (under the dynamics Gibbsianness can be lost and  can be recovered).  Our analysis expands the work of Ermolaev and Kulske who considered zero  magnetic field and finite-temperature spin-flip dynamics. We consider both zero  and non-zero magnetic field but restricted to infinite-temperature spin-flip  dynamics. Our results reveal an interesting dependence on the interaction  parameters, including the presence of forbidden regions for the optimal  trajectories and the possible occurrence of overshoots and undershoots in the  optimal trajectories. The numerical plots provided are obtained with the help  of MATHEMATICA.","palabras_clave":"CURIE-WEISS MODEL|SPIN-FLIP DYNAMICS|GIBBS VS NON GIBBS|LARGE DEVIATIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1952,"idioma_id":4,"titulo":"Hunting, Herding, and Caravanning: Osteometric Identifications of Camelid Morphotypes at Khonkho Wankane, Bolivia","resumen":"Khonkho Wankane is a ceremonial center located in the southern Lake Titicaca Basin, Bolivia. During the Late Formative period (AD 1?500), its residents practiced agropastoral lifeways and participated in the rise of the state at Tiwanaku. Like at many Andean sites, bone elements from the family Camelidae represented by these bones carries far-reaching implications for understanding past hunting, herding, and caravanning practices, and their roles in larger social and economic webs. Identifications were based on a locally focused reference collection, including llamas from the immediate vicinity of the site, as well as Andean guanacos, a much smaller morphotype than the Patagonian guanacos used in many osteometric studies. Multivariate statistical analyses identified all four camelids species, whose presence was confirmed by incisor morphology. Similar results are apparent in bivariate and multivariate analyses, suggesting that the crux of osteometry lies in the reference collection, not the statistical test. An additional, very large morphotype likely corresponds to a castrated llama, the preferred cargo animal among modern drovers. The data is interpreted as evidence that groups hunted vicuña and guanaco, which are not currently present around the site, herded llamas and alpacas, and perhaps organized caravans with castrated llamas.","palabras_clave":"Osteometry|South American Camelids|Hunting |Pastoralism|Caravans|Khonkho Wankane, Bolivia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1953,"idioma_id":4,"titulo":"Morphophysiological characterization in artichoke accessions aimed at selecting materials for in natura consumption","resumen":"A morphophysiological characterization of 19 accessions within an artichoke germplasm collection was conducted with the aim of determining genetic variability and to select materials suitable for in natura consumption to be used in genetic breeding. The collection was composed of commercial accessions, materials collected in South Brazil, and of foreign origin. Twenty quantitative, five multicategorical and two binary traits were evaluated. Quantitative data were submitted to a multivariate  analysis. Genetic variability was observed for almost all characteristics. The traits with the greatest relative contribution to genetic divergence, which accounted for 79.54% of the variability, were as follows: the thickness and diameter bottom, bottom fresh mass\/head fresh mass ratio, external bract length, bracts base, leaves and primary head height and plant diameter, primary head diameter and bracts base thickness. A  cluster analysis revealed four groups. Group I aggregated the accessions with characteristics for fresh consumption. The best accessions were Romanesco 1, Green Globe, and Improved Green Globe, all of which exhibited plants with a greater fresh mass, larger primary head diameter, greater fresh mass and bottom diameter, circular head shape, no thorns, round head tip and desired color, that are important traits for selection of superior genotypes for in natura consumption.","palabras_clave":"CYNARA CARDUNCULUS VAR. SCOLYMUS (L.) Fiori,|GENETIC VARIABILITY|GERMOPLASM|MULTIVARIATE ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1954,"idioma_id":5,"titulo":"Variabilidad de estrategias tecnológicas líticas durante el Período Formativo (ca. 2400 - 1400 ap) en la puna de Salta","resumen":"Aquí se desarrolla el resumen de la tesis doctoral del mismo nombre, el cual constituye un aporte al conocimiento de las tecnologías líticas de las primeras sociedades productoras de alimentos de las tierras altas del Noroeste Argentino. El interés es explorar la diversidad de conjuntos líticos que comparten ciertas características contextuales en un área y un tiempo relativamente acotados: la Puna de Salta durante el Formativo. Asimismo, a partir de este estudio tecnológico lítico, el desarrollo del trabajo está orientado a vincular la diversidad de las estrategias de subsistencia, las interacciones sociales y los procesos de transmisión cultural que tuvieron lugar en dos áreas de la Puna salteña.","palabras_clave":"MATERIAL LITICO|PUNA DE SALTA|PERIODO FORMATIVO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1956,"idioma_id":4,"titulo":"A new species of Scopinella from pampas grass in Argentina","resumen":"A previously undescribed species of the genus Scopinella was found during \ta survey of the fungi associated with Cortaderia selloana (Poaceae) in Argentina. The ascospores are strongly asymmetrical and have the shape of a truncated pyramid with a convex cuadrangular base. This peculiar ascospore shape sets this species, described here as new, apart from the others of the genus. This is the second record of Scopinella from South \tAmerica.","palabras_clave":"ASCOMYCETES|CORTADERA|SCOPINELLA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1957,"idioma_id":4,"titulo":"HIV-1 BF intersubtype recombinant Vpu second alpha helix plays an important role in the viral release and BST-2 degradation","resumen":"We previously reported a naturally occurring BF intersubtype recombinant Vpu variant with augmented capacity to enhance viral replication. Structural analysis of this variant revealed that its transmembrane domain (TMD) and &#945;-helix I in the cytoplasmic domain (CTD) corresponded to subtype B, whereas CTD &#945;-helix II corresponded to subtype F1. This work was aimed at evaluating the role of Vpu CTD &#945;-helix II domain on viral release enhancement and down-modulation of BST-2 and CD4 from cell surface. In addition, as serine residues in either Vpu amino acid positions 61 or 64 have been shown to regulate Vpu intracellular half-life, which in turn could influence the magnitude of viral release, we also studied the impact of these residues in the BF Vpu functions, since S61 and S64 are infrequently found among BF recombinant Vpu variants. Our results showed that interchange of Vpu &#945;-helix II between subtypes (B&#8594;F) directly correlated with enhancement of viral release and, to a lesser extent, with changes in the capacity to down-modulate BST-2 and CD4 of the resulting chimera. No statistical differences on viral release and BST-2 down-modulation were observed between Vpu BF and VpuBF E61S. On the other hand, VpuBF A64S showed a slightly reduced capacity to enhance viral production but was modestly more efficient than VpuBF in down-modulating BST-2. In summary, our observations clearly evidence that &#945;-helix II is actively involved in Vpu viral release-promoting activity, and that intersubtype recombination between subtypes B and F1 originated a protein variant with higher potential to boost the spread of the recombinant strain that harbors it.","palabras_clave":"HIV-1|Vpu|Recombination|viral release"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1958,"idioma_id":4,"titulo":"Developing country applications of molecular farming: Case studies in South Africa and Argentina.","resumen":"    Molecular farming is a technology that is very  well suited to being applied in developing countries, given the reasonably high  level of expertise in recombinant plant development in many centres. In  addition, there is an urgent need for products such as inexpensive vaccines and  therapeutics for livestock and for some human diseases ? and especially those  that do not occur or are rare in developed regions.&nbsp; South Africa and Argentina have been at the  fore in this area among developing nations, as researchers have been able to  use plants to produce experimental therapeutics such as nanoantibodies against  rotavirus and vaccines against a wide variety of diseases, including Rabbit  haemorrhagic disease virus, Foot and mouth disease virus, Bovine viral  diarrhoea virus, bovine rotaviruses, Newcastle disease virus, rabbit and human  papillomaviruses, Bluetongue virus, and Beak and feather disease virus of  psittacines.&nbsp; A combination of fortuitous  scientific expertise in both places, coupled with association with veterinary  and human disease research centres, has enabled the growth of research groups  that have managed to compete successfully with others in Europe and the USA and  elsewhere, to advance this field.&nbsp; This  review will cover relevant work from both South Africa and Argentina, as well  as a discussion about the perspectives in this field for developing nations.  ","palabras_clave":"molecular farming|transgenic plants|vaccines |antigen expression"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1959,"idioma_id":4,"titulo":"Developmental and polyamine metabolism alterations in Rhinella arenarum embryos exposed to the organophosphate chlorpyrifos","resumen":"Organophosphorus pesticides (OP) are widely applied in the Alto Valle of   Río Negro and Neuquén due to intensive fruit growing. Amphibians are   particularly sensitive to environmental pollution and OP may transiently   accumulate in ponds and channels of the region during their reproductive   season. OP exposure may alter amphibian embryonic development and the   reproductive success of autochthonous species. In the present study,   embryos of the common toad Rhinella arenarum were employed to assess   developmental alterations and to study polyamine metabolism, which is   essential to normal growth, as a possible target underlying the effects of   the OP chlorpyrifos. As the duration of chlorpyrifos exposure increased and   embryonic development progressed, the LC50 values decreased and the   percentage of malformed embryos increased. Developmental arrest was   also observed and several morphological alterations were recorded, such   as incomplete and abnormal closure of the neural tube, dorsal curvature of   the caudal fin, reduction of body size and caudal fin length, atrophy and   edema. An early decrease in ornithine decarboxylase (ODC) activity and   polyamine levels was also observed in embryos exposed to chlorpyrifos.   The decrease in polyamine contents in tail bud embryos might be a   consequence of the reduction in ODC activity. The alteration of polyamine   metabolism occurred before embryonic growth was interrupted and   embryonic malformations were observed, and may be useful as a   biomarker in environmental studies.","palabras_clave":"AMPHIBIAN|PESTICIDES|BIOMARKERS|POLYAMINES|ORNITHINE DECARBOXYLASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1961,"idioma_id":5,"titulo":"El análisis de las virtudes y fortalezas en la infancia","resumen":"Dentro del marco de la psicología positiva existe una línea de investigación centrada en el estudio de las virtudes y fortalezas, entendidas como una familia bien constituida de rasgos positivos del carácter, las cuales permiten adoptar una perspectiva más abierta respecto al potencial humano, sus motivaciones y capacidades (Sheldon & King, 2001).La infancia constituye un momento propicio para detectar y potenciar las virtudes y fortalezas que propone la psicología positiva, debido a que provee al niño una base que le permitirá afrontar los retos más importantes de la adolescencia (Park & Peterson, 2006).El presente artículo  se propone realizar una revisión sobre las investigaciones efectuadas en el ámbito de la infancia acerca de las virtudes y fortalezas. Asimismo, se describen algunos de los beneficios que el estudio de las potencialidades puede tener en el desarrollo de programas educativos de prevención y de intervención.","palabras_clave":"Psicología Positiva|Niños|Virtudes|Fortalezas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1962,"idioma_id":4,"titulo":"Optimizing salmon farm cage net management using integer programming","resumen":"Salmon farming in Chile constitutes one of the nation´s principal food exporting sectors. In the seawater stage, one of the most important in the farm production chain, salmon are cultivated in floating cages fitted with nets that hold the fish during the entire grow-out process. The maintenance of the cage nets is carried out at land-based facilities. This article reports on the creation of an integer programming tool for grow-out centres that optimizes resource use, improves planning and generates economic evaluations for supporting analysis and decision-making relating to the maintenance, repair and periodic changing of cage nets. The tool prototype was tested in a single operating area of one of Chile´s largest salmon farmers. The results demonstrated a reduction in net maintenance costs of almost 18%, plus a series of important qualitative benefits. Implementation of the tool by farm operators awaits the end of the current crisis in the industry.","palabras_clave":"integer programming|salmon industry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1964,"idioma_id":4,"titulo":"The politics of federalism in Argentina and its implications for governance and accountability","resumen":"Over the past decade and a half, a burgeoning literature on the political economy of federalism has emerged assessing the impact of federal institutions on political and economic policy outcomes in comparative perspective. We contribute to this rich literature in two ways. We first provide a ?general equilibrium? perspective on the workings of federalism in a highly decentralized middle-income democracy, Argentina, by focusing on the incentives of the main subnational political actors (e.g. governors), the institutional sources of those incentives, and a description of the main features of political competition at the provincial level. Based on the stylized fact that most provinces are local bastions of power dominated by entrenched elites, characterized by scarce political competition, weak division of powers, and clientelistic political linkages, we then build an argument about the reinforcing connection between political dominance at the provincial level and political importance at the national level, and explore its implications for national policymaking, governance and accountability. In particular, we argue that a strong domination of provincial politics is a valuable commodity in national politics: a governor that has a clear control of the provincial contingent in national Congress can credibly exchange future votes in Congress for current fiscal favors; a governor that has a strong grasp on the provincial political machinery can credibly promise future electoral support for a president seeking reelection. Thus, we expect governors that dominate the provincial political sphere to weight more heavily in the national policymaking game. We test the plausibility of this argument using panel electoral and fiscal data on the 24 provinces between 1983 and 2007 and find some initial empirical support for it.","palabras_clave":"federalism|representation|accountability|argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1965,"idioma_id":5,"titulo":"'El juego' en los sistemas gramaticales y la coexistencia de variedades de una lengua","resumen":"El uso de las lenguas nos muestra que, porque las categorizaciones responden a continuum semánticos, las fronteras entre los espacios categoriales \u2013 es decir, hasta dónde llega el significado de una forma lingüística y dónde comienza el significado de la otra- son ilusorias y responden a la decisión \/concertación de los hablantes. Esto mismo hace que dichas fronteras puedan desplazarse  \u2014incluso sin que los significados se recategoricen\u2014 de manera que, en un momento determinado, una forma lingüística comience a ocupar parte del espacio de la otra.   Desde nuestra perspectiva, es esta la clave de la conformación de las distintas variedades de una lengua, las cuales se diferencian, en general, por el espacio que ocupan las instancias categoriales dentro de sus paradigmas.  En este trabajo desarrollaremos el concepto de \u201Cjuego intra-paradigmático\u201D que creemos puede explicar el proceso de conformación de distintas variedades.  Ejemplificaremos mediante la confrontación de dos variedades del español de la Argentina en lo que respecta al empleo de los clíticos de tercera persona y trataremos de explicar el juego intra-paradigmático a la luz de estrategias etnopragmáticas.","palabras_clave":"GRAMATICA|VARIACION|VARIEDADES|SISTEMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1966,"idioma_id":4,"titulo":"Cloacal mycobiota in wild females of Caiman latirostris (Crocodylia: Alligatoridae)","resumen":"Abstract. There are few reports of cloacal mycobiota on wild reptiles, and in particular, fungal presence and function in Caiman latirostris remains unknown. Our objective was to describe the fungal community present in the cloaca of wild female broad-snouted caimans during their reproductive season determine whether the number of fungi has some relationship with the female?s corporeal condition. Fungi were found in 9 out of 13 cloacal samples and 14 species of fungi were isolated and identified. Three of the species isolated had the highest occurrence values, and 2 of them are pathogenic. In this case, body condition index had no relationship with fungal frequency; the fungi found in this study may have originated from soil habitat and nest substrate that are in constant contact with the cloaca of the C. latirostris females. The findings in this work support the theory that reptiles are facultative carriers of fungi or their spores.","palabras_clave":"Yacaré Overo|broad-snouted caiman|filamentous fungi|wild reptiles|yeasts|pathogens"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1967,"idioma_id":5,"titulo":"Contaminación de las fuentes de agua y sus efectos sobre el sistema nervioso y la conducta","resumen":"El problema en las sociedades modernas no es sólo la cantidad de agua en las fuentes disponibles, sino también la calidad de la misma. Por esta razón, la contaminación de las fuentes de agua es un tema de vital importancia que afecta el desarrollo de las poblaciones humanas actuales, generando distintos tipos de patologías en el sistema nervioso y el comportamiento. La psicobiología y las neurociencias permiten abordar este tema, estudiando los mecanismos que actúan en estos fenómenos y planteando al mismo tiempo potenciales soluciones a los problemas que origina la necesidad de hacer un uso racional del agua, recurso cada vez más escaso y puesto en riesgo por el tratamiento inadecuado de los recursos naturales en las sociedades modernas. En este artículo se incluyen los siguientes temas: a) El hidroarsenicismo: un problema de contaminación de las aguas de napa y fluentes que originalmente afectaba una región circunscripta de nuestro país y que se encuentra en expansión, afectando ya varias provincias. Genera trastornos del desarrollo, enfermedades del sistema nervioso y distintos desórdenes del comportamiento. b) La combinación con otros contaminantes de las aguas, originados por la explotación de recursos podría tener efectos impredecibles. c) El uso de sensores biológicos, en la forma de organismos en los que se estudien los efectos conductuales y fisiológicos de las contaminaciones de las aguas es un recurso apropiado para enfrentar la problemática planteada.","palabras_clave":"SISTEMA NERVIOSO|CONDUCTA|CONTAMINACIÓN|FUENTES DE AGUA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1968,"idioma_id":5,"titulo":"Inseminación artificial con semen refrigerado en llama","resumen":"El  mejoramiento genético de los camélidos sudamericanos (CSA) está limitado, entre  otros, por los siguientes factores: un intervalo generacional largo, un período  prolongado de gestación de 342 a 350 días y hembras monotocas que pueden tener  un máximo de 4 crías en toda su vida reproductiva. La aplicación de  biotecnologías reproductivas permitiría acortar los tiempos generacionales,  favorecer la propagación genética de animales superiores con mayor rapidez y  formar un banco genético mediante la criopreservación de gametas. Aunque la inseminación  artificial (IA) con semen preservado ha tenido muy buenos resultados en las  diferentes especies domésticas, permitiendo el mejoramiento genético (especialmente  en el ganado bovino), no ha sido así en los CSA. Los porcentajes de preñez del  0 al 10 % obtenidos hasta el momento al inseminar con semen refrigerado o  congelado de llama y alpaca (Bravo et al., 2000; Aller et al., 2003; Vaughan et  al.,2003), indicarían que los espermatozoides de estas especies sufren un  deterioro en su capacidad fertilizante, porque a pesar de que se insemine igual  cantidad de espermatozoides viables y móviles, con el semen criopreservado se  obtiene un menor porcentaje de preñez que con semen fresco. ","palabras_clave":"semen|camelidos|inseminacion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1970,"idioma_id":5,"titulo":"INFLUENCIA DEL ENVEJECIMIENTO DE LOS MATERIALES EN SU DESEMPEÑO TÉRMICO. EL CASO DE REVESTIMIENTOS TEXTURADOS PARA FACHADAS","resumen":"The results presented in this article are framed within a research project that studies solutions for urban spaces (morphology, materials,  construction techniques, etc.) in order to mitigate the impact of Urban Heat Islands. The cold materials present in the urban envelope  help to reduce energy demand for cooling in air conditioned buildings and improve the comfort of open spaces, contributing to  environmental sustainability through the rational use of energy. Solar reflectance of the building envelope tends to change with time due  to outdoors and dirt accumulation. Therefore, for a period of two years it was measured thermo-physical behavior of 80 textured  coatings for facades on two compositions: acrylic (SIP) and cement (CW), with colors, textures and finishes spread locally to the  vertical resolution of the urban envelopes. The variation of the thermal behavior with erosion was evaluated by modifying the Solar  Reflectance indicator over time. Solar Reflectance Index -SRI- is defined as the determination of the solar reflectance, thermal emitancia  and the relative temperature of the surfaces with respect to a reference temperature of a black and white pattern. This index allows  weighting the effect of aging on the thermal behavior of the materials evaluated. The results show that 35% of acrylic coatings decrease  their ability to mitigate the effects of heat island, while 98% of the cementitious maintained or increased their capacity of mitigating.","palabras_clave":"Envejecimiento de Materiales|Propiedades Ópticas|Índice de Reflectancia Solar"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1974,"idioma_id":4,"titulo":"Case study: Microfibril angle and its relationship with basic density in Pinus taeda L. wood from silvopastoral systems","resumen":"The material resulting from fast-growing plantations is presumed to present a high percentage of juvenile wood, with high microbril angle (MFA) and low basic density (BD), which would negatively affect the technological properties of wood. The objective of this study was to measure the MFA using the technique of the orientation of bordered and cross-!eld pit apertures of the tracheids walls, determine BD and verify the correlation between the two variables. The used material was Pinus taeda 15 years old from a stand with silvopastoral management. The pit apertures of the earlywood tracheids showed to be more rounded and abundant compared to those of the latewood. The MFA decreased from 56.2 to 42.1 degrees, and wood density increased from 0.31 to 0.42 g\/cm3 from the pith to the bark. The high values of MFA could be explained by the genetic material with low degree of breeding, and also by the wide spacing between trees - which favors the fast growth-, but could also be due to the employed methodology. The correlation between MFA and density in this study is moderate and negative (R= -0.59), indicating that density would not be a parameter suficient to infer about the structural quality of the wood.","palabras_clave":"ANGULO MICROFIBRILAR|PINUS TAEDA|DENSIDAD BÁSICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1975,"idioma_id":4,"titulo":"Decoupling of paired elements, crossover REE patterns, and mirrored spider-diagrams: fingerprinting liquid immiscibility in the Tapira Alkaline-Carbonatite Complex, SE Brazil.","resumen":"the Late-Cretaceous Alto Paranaíba Igneous Province (APIP). It is dominated by coarse-grained plutonicrocks (bebedourite e a phlogopite-, apatite-, and perovskite-rich clinopyroxenite e with subordinateddunites, wehrlites, carbonatites and phoscorites). The plutonic rocks are crosscut by fine-grained ultramaficalkaline rocks (phlogopite picrites, bebedouritic dikes) and fine-grained carbonatites. Both types ofdike-rocks show petrographic evidence of the coexistence of immiscible silicate and carbonatite liquids,such as carbonate ocelli present in the silicate rocks and, more rarely, silicate ocelli within carbonatites. Adetailed geochemical study of the rock types in the complex, with emphasis on the fine-grained varieties,showed that whilst some rocks may be related to each other through crystal fractionation (e.g. phlogopitepicrites and bebedouritic dikes), others display anomalous trace-element behaviour that cannot bereadily explained by the fractionation of a particular phase or combination of phases. We interpret suchanomalous geochemical signatures as produced by silicateecarbonate liquid immiscibility, on the basis ofavailable experimental data on partition coefficients between coexisting immiscible liquids. Theimmiscibility signatures comprise: (a) decoupling of geochemical pairs, such as NbeTa and ZreHf; (b)rotation of REE patterns, which cross over the patterns of the primitive liquids; and (c) matching andopposite enrichment-depletion trace elements relationships in spider diagrams of conjugate immiscibleliquids. We suggest that, once established, such geochemical signatures are very difficult to erase duringthe subsequent petrogenetic evolution processes, which may result in superimposed conflictingsignatures.","palabras_clave":"Brazil|REE|Spider|Alkaline"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1976,"idioma_id":5,"titulo":"Perdonar y reconciliarse. La Iglesia católica argentina, el retorno de la democracia y la revisión de las violaciones a los derechos humanos?","resumen":"Las herencias de la represión estatal durante los años de la última dictadura constituyeron uno de los principales desafíos para la dirigencia política argentina desde el retorno democrático. Muchas de las ideas que poblaron los discursos políticos fueron enunciadas previamente por los obispos argentinos. Sandrine Lefranc le atribuye a la Iglesia argentina la elaboración de una doctrina de la reconciliación, explícitamente disponible para su traducción política, sino jurídica. Esta imagen debe ser complejizada con la incorporación de otras voces que dentro del Episcopado plantearon una caracterización diferente de lo que debía ser la reconciliación. Estos serán los ejes a través de los cuales se abordarán los posicionamientos de los obispos frente a los procesos de enjuiciamiento de militares iniciados en 1984.","palabras_clave":"DERECHOS HUMANOS|PERDÓN|RECONCILIACIÓN|IGLESIA CATÓLICA|JERARQUÍA ECLESIÁSTICA|DEMOCRACIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1977,"idioma_id":5,"titulo":"Una minuciosa reconstrucción de la trayectoria de El Pueblo. A propósito de La rotativa de Dios. Prensa católica y sociedad en Buenos Aires: EL Pueblo, 1900 ? 1960, de Miranda Lida","resumen":"Quien esté interesado en la trayectoria de El Pueblo, sin dudas el diario católico argentino más importante del siglo XX, puede encontrar en las librerías el reciente trabajo de la historiadora Miranda Lida, La rotativa de Dios. En nuestro país, los estudios sobre la prensa católica se han desarrollado en los últimos años aunque, en general, limitándose a la descripción del perfil ideológico de los medios o de sus posicionamientos frente a los hechos políticos más importantes. El mencionado libro de Lida se aleja de esta perspectiva, para ofrecer un análisis de mayor densidad que integra una mirada de lo político y lo cultural desde la historia social","palabras_clave":"PRENSA|EL PUEBLO|CATOLICISMO|SOCIEDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1978,"idioma_id":4,"titulo":"The archaic ilial morphology of an enigmatic pipid frog from the upper Pleistocene of the South American pampas","resumen":"ABSTRACT?Pipids are odd-looking frogs with a derived morphology that has been considered to be the result of a successful adaptation to a fully aquatic lifestyle. This monophyletic group comprises 33 extant species arranged in three clades mainly distributed in tropical regions of northern South America (Pipa) and sub-Saharan Africa (Xenopodinae and Hymenochirini). Their fossil record, however, documents greater diversity and wider distribution in South America in the Cretaceous and Paleogene. Recently, isolated postcranial bones bearing distinctive pipid features have been collected from Pleistocene beds in Argentina, nearly 2000 km farther south than their present distribution on the continent. Herein we describe a well-preserved pipid ilium possessing features unknown in the living taxa. The fossil is from a new Lujanian (Late Pleistocene) locality of the Pampean Region, thereby confirming the intriguing presence of this group in southern South America. We provide a detailed anatomical evaluation of the adult iliac morphology of pipimorphs and use these data, along with molecular data, in a parsimony analysis of living and extinct pipoid taxa to estimate the relationships of the new material. This analysis places the fossil as a stem xenopodine in an unresolved polytomy together with ?Xenopus? romeri from the Upper Paleocene?Lower Eocene of Brazil and two taxa from the Eocene of Patagonia. These Pleistocene pipid records in the Pampean region and subsequent disappearance may reflect latitudinal shifts owing to the rapid climate changes related to the glacial\/interglacial cycles.","palabras_clave":"PIPIDAE|ILIUM|PLEISTOCENE|LUJANIAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1979,"idioma_id":4,"titulo":"How thick do consumers' wnat their meat and how thick do they get it? The case of deep-fried breaded beef","resumen":"The main objective was to estimate the optimum thickness of meat from a consumers' perspective. Breaded beef (known as 'milanesa' in Spanish speaking countries and as 'schnitzels' in Austria) is a food product prepared with a slice 01meat that is dipped in beaten egg to then be covered in bread crumbs; thus prepared it is tried. This product was used as a case study. Breaded beef was evaluated in three different stages: raw slice of meat, appearance of meat after frying, and during mastication. Breaded beef prepared with meat of varying thicknesses were presented to consumers who evaluated if the thicknesses were too thin, ok or too thick. Survival analysis statistics were used to estimate the optimum thicknesses. Results for each stage were: raw slice of meat=6.7±0.2 mm, appearance of the cut fried breaded beef=8.4±.0.3mm and during mastication = 7.6 ± 0.3 mm. The average thickness of the meat cut by butchers tor breaded beef was 5.9 mm, not too far from the optimum. However, the average thickness of the meat in the breaded beef ready for frying sold by the same butchers 3.7 mm, clearly thinner than the optimum.","palabras_clave":"Breaded beef|Optimum thickness|Sensory analysis|Survival analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1980,"idioma_id":4,"titulo":"Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2- hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate.","resumen":"The aim of this work was to synthesize and to characterize new pH -sensitive hydrogels that can be used in the controlled release of drugs,useful for dermal treatments or ophthalmology?s therapies. Copolymerscontaining 2-hydroxyethyl methacrylate (HEMA) with different amounts of2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt. %) anddifferent amounts of cross-linker agent , ethylene glycol dimethacrylate(EGDMA) (1 and 3 wt. %) were prepared by bulk photo-polymerization.The copolymers were fully characterized by using FT-IR, DSC, TGA, UVvisiblespectroscopy, and measuring water content and dynamic swellingdegree. The results show that modifications in the amount of DPA and\/orcross-linker in the hydrogel produce variations in the thermal properties.When adding of DPA, we observed an increase in the thermal stability anddecomposition temperature, as well as a change in the mechanism ofdecomposition. Also a decrease in the glass transition temperature wasobserved with regard to the value for pure pHEMA, by the addition of DPA.The water content of the hydrogels depends on the DPA content and it isinversely proportional to both the pH value and the cross-linking degree.Pure polyHEMA films did not show important changes over the pH rangestudied in this work. The dynamic swelling curves show the overshootingeffect associated with the incorporation of DPA, the pH of the solution andthe cross-linking density. On the other hand, no important variations in theoptical properties were observed. The synthesized hydrogels are useful asa drug delivery pH-sensitive matrix.","palabras_clave":"STIMULI-SENSITIVE POLYMERS|HYDROPHILIC POLYMERS|DRUG DELIVERY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1982,"idioma_id":5,"titulo":"Morfología de gotas apoyadas o colgadas bajo la acción de la gravedad, tensión superficial y de fuerzas de London\/van der Waals y electrostáticas","resumen":"En este trabajo se presentan expresiones analíticas que describen la forma de gotas bidimensionales, apoyadas o colgadas de un sustrato, sometidas a la acción de la gravedad, la tensión superficial y las fuerzas moleculares que surgen entre el líquido y el sustrato. Estas últimas son del tipo London\/van der Waals y electrostáticas, y son responsables de la existencia de una película nanométrica en la región cercana a la l´ &#305;nea de contacto. Se presentan expresiones que vinculan aspectos micro y nanoscópicos, tales como la intensidad de las fuerzas moleculares y el espesor de la película precursora, con cantidades macrosc´ opicas, como el área transversal, la altura y el ancho de la gota. Se investiga especialmente el efecto de la gravedad sobre las características de la gota.","palabras_clave":"Gotas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1983,"idioma_id":5,"titulo":"(Des) montaje y sabotaje de discursos y prácticas en torno al cuerpo y la muerte en las fronteras entre las artes y las ciencias","resumen":"El presente artículo surge de un encuentro transcultural y transdisciplinar entre dos sujetos cuyas historias se encuentran signadas por intensos procesos migratorios que han dejado una profunda huella en sus cuerpos y en sus palabras. Una catalana cuya experiencia se ve atravesada en algún punto por una actividad de compromiso corporal, y una cordobesa nacida en Argentina, de ascendencia española, siria y musulmana cuya formación ha transitado los campos de las artes, las ciencias sociales, la Psicología y el Psicoanálisis. Vaya esta aclaración para dar cuenta de nuestra toma de posición y de consciencia respecto de quiénes somos y hacia dónde procuramos orientar nuestras prácticas en el marco de un sistema que ejerce el dominio sobre el cuerpo, la mente y la muerte a través de dispositivos y estrategias desplegadas en los más diversos campos sociales.","palabras_clave":"DES-MONTAJES|SABOTAJES|CUERPO|PEDRO ARA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1986,"idioma_id":5,"titulo":"Bodegas sobre-suelo y estabilidad térmica interior. Análisis de envolventes tradicionales y contemporáneas en Mendoza, Argentina.","resumen":"El control en el intercambio de flujos energéticos interior-exterior y la inercia térmica de los materiales constructivos son características claves de la envolvente de los edificios de bodegas. Esta situación es particularmente importante en el caso de los edificios construidos sobre-suelo en climas con temperaturas diarias y estacionales muy variables. En el caso de que la arquitectura no provea la respuesta adecuada, indefectiblemente se recurre al consumo de energía auxiliar. La bodega S.A., ubicada en Mendoza, Argentina consume energía auxiliar equivalente a 2.500 kW por año. Dicha bodega sobre-suelo presenta dos tipos de envolvente vertical: una tradicional en adobe (k = 0.81W\/mK) y otra contemporánea en chapa galvanizada sin aislación (k = 45 W\/mK). El objetivo de este trabajo es analizar los aspectos de materialidad, inercia térmica e intercambio de flujos energéticos de envolventes tradicionales y contemporáneas y, comparar los resultados obtenidos con un caso teórico de bodega subterránea. Entre los resultados obtenidos se observa que la envolvente tradicional mantiene las temperaturas interiores entre 8,5ºC y 10ºC por debajo de las temperaturas exteriores, mientras que los nuevos espacios con envolventes contemporáneas lo hacen sólo 3ºC a 5ºC por debajo de las temperaturas exteriores. Para el caso de una bodega subterránea, las temperaturas estarían estables todo el año en 16,5ºC; esto es, en verano, 20ºC por debajo de las temperaturas exteriores.","palabras_clave":"ESTABILIDAD TÉRMICA|ENVOLVENTES TRADICIONALES|ENVOLVENTES CONTEMPORÁNEAS|BODEGAS SOBRE-SUELO Y CONTEMPORÁNEAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1987,"idioma_id":5,"titulo":"Estudios de relación estructura  actividad sobre surfactantes gemini con actividad antimicrobiana","resumen":"    En este trabajo se diseñaron y sintetizaron seis compuestos gemini peptídicos no iónicos denominados 3a-f y tres gemini iónicos denominados 3d*, 3e* y 3f* los cuales varían estructuralmente en sus regiones polar e hidrofóbica. Los rendimientos obtenidos para los gemini no iónicos fueron del 40-65 % y para los iónicos del 80 %. En función de su variabilidad estructural los mejores resultados de actividad antimicrobiana y de superficie se obtienen cuando las moléculas presentan en su región hidrofóbica cadenas insaturadas de 15 carbonos y residuos de triptofano, y la región polar presenta residuos de ornitina adyacentes. Los compuestos de mayor actividad obtenidos (gemini 3a y 3b) son atractivos tecnológicamente por su bajo peso molecular, su forma simple de obtención, favorables propiedades de superficie y elevada actividad biológica, fundamentalmente frente a bacterias causantes de enfermedades de transmisión alimentaria, como algunas especies de Bacillus y Listeria monocytogenes. En particular el gemini 3b tendría además un uso potencial en el campo de la salud humana debido a su actividad frente a Staphylococcus aureus y su baja toxicidad. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;     ","palabras_clave":"GEMINI PEPTIDICO|N- ALQUILACION|ANTIMICROBIANOS| L-ORNITINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1989,"idioma_id":5,"titulo":"Aportes de la ornitología marina a la visión ecosistémica del manejo pesquero","resumen":"Al menos unas 70 especies de aves marinas se alimentan en la plataforma continentalargentina, que es posiblemente el área con mayor biomasa de albatros en el mundo. La distribuciónde las aves en el mar generalmente coincide con la de las pesquerías comerciales en áreas conelevada productividad marina, por lo que sus interacciones pueden ser frecuentes y diversas. Elabordaje del Mar Argentino considerando a las aves como parte de un enfoque integrado representaun desafío. Algunos aspectos de la biología de estas aves podrían actuar como indicadoresambientales permitiendo interpretar los sistemas, evaluar su estado de conservación y analizarrelaciones con procesos globales. Aunque las interacciones entre las aves y algunas flotas pesquerasque operan en la plataforma todavía no han sido estudiadas, el conocimiento sobre la ecología, elcomportamiento y la conservación de estas aves ha crecido significativamente en la última década.Incluir consideraciones ecosistémicas en el manejo de la pesca es contribuir a largo plazo a laseguridad alimentaria y a asegurar una efectiva conservación y uso sostenible del ecosistema ysus recursos.","palabras_clave":"AVES MARINAS|ENFOQUE ECOSISTEMICO|PESQUERIAS|PLATAFORMA CONTINENTAL ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1990,"idioma_id":4,"titulo":"Synthesis of photoaddressable polymeric networks having azobenzene moieties and alkyl chains-containing compounds","resumen":"We discuss the synthesis of new optically active polymeric networks containing azobenzene moieties and different alkyl-chain containing compounds. An epoxy resin based on diglycidyl ether of bisphenol A(DGEBA) was reacted with metaxylylenediamine (MXDA). An azo prepolymer (TAZ) was synthesized by reaction between Disperse Orange-3 and DGEBA. Reaction betweenpalmitic acid (PA) and DGEBA was performed using triphenylphosphine as catalyst of the epoxy?acid reaction employing variable molar ratios of epoxy to carboxyl groups (r = 1, 2, 4). These precursors were called PA1, PA2 and PA4. Crosslinked epoxy-based azopolymers containing variable PA-based precursor content and constant chromophore concentration equal to20 wt% TAZ were synthesized. Their reversible optical storage properties were studied and compared. It was found that the optical response is a direct consequence of the morphologies generated, and that crystallization of PA-based precursor can take place. When the PA-based precursor is not covalently bonded to the matrix, e.g. PA1, the remaining birefringence is high.PA4-modifiedmaterials present a completely different response, showing a behaviour that could be of great importance in the development of optical switchers. In this case, the organic tails remain dissolved in the matrix and unable to crystallize, giving a typical ?on?off? response.","palabras_clave":"PHOTOINDUCED ANISOTROPY|AZOPOLYMER|EPOXY NETWORK|PALMITIC ACID"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1991,"idioma_id":4,"titulo":"Schooling and Governance: Pedagogical Knowledge and Bureaucratic Expertise in the Genesis of the Argentine Educational System","resumen":"The constitution of the Federal Government meant to modernise local societies, produce institutional complexes and reach political stabilisation. The deployment of modern schooling articulated utopia and bureaucracy using the image of knowledge as an instrument of social intervention, vindicating and legitimising the concept of rational control.   These coordinates established the formal and material bases to constitute the pedagogical knowledge on the one hand, and a field of bureaucratic knowledge on the other hand.  These fields involved different ways of articulating the regulation devices of the educational system.   If the normalist pedagogical knowledge involved a set of instructions on schooling, the bureaucratic knowledge of inspectors resulted in the schooling process regulations.","palabras_clave":"Schooling|pedagogical knowledge |bureaucratic expertise |governance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1992,"idioma_id":5,"titulo":"Historia y trayectoria de educadores santafesinos: resignificaciones de la noción de educación popular","resumen":"Cuando pensamos la historia de laeducación argentina en sus grandes trazos, hay momentos en los que nuestramirada hace foco, específicamente en algunos lugares de nuestro mapa: larenovación y experimentación entrerriana en los comienzos del normalismo, elgobierno escolar y la sociedad civil a través de consejos escolares en laprovincia de Buenos Aires, la Reforma Universitaria en Córdoba, etc. Cuandopensamos la primera gran crítica y renovación del sistema educativo del sigloXIX a partir del ingreso de las nuevas ideas de la escuela nueva, nuestrasmiradas se dirigen a Santa Fe.&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;Durante la segunda mitad delsiglo XIX, el desarrollo de la escolarización transitó un recorrido consignificativos obstáculos. La organización de formas sistemáticas deinstrucción ?diversas, en simultáneo, atendiendo a poblaciones acotadas- era coincidentecon la formación del estado y se fue dando, en buena medida, a través de lacreación de un conjunto de instituciones, normas y un incipiente aparatoburocrático y de gobierno específico. Así, el camino seguido por la expansiónescolar no fue un camino unidireccional de progreso, sino que contuvo marchas ycontramarchas, con posiciones contrapuestas, oposiciones personales yresistencias a los cambios. Poner el lente sobre la acción de algunoseducadores en el marco de las directrices generales y las decisiones degobierno muestra las traducciones, debates y alteraciones que se fueronhaciendo de las direcciones generales. Nos interesa situar aquí de manerasucinta, el clima de renovación pedagógica de las primeras décadas del sigloXX, donde educadores santafesinos participaron de planteamientos nuevos para elsistema educativo antes, durante y a posteriori del ingreso del escolanovismoen el país.","palabras_clave":"Historia de la Educación|Reformadores santafesinos|Escuela nueva|Educacion popular"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1993,"idioma_id":4,"titulo":"Impaired theory of mind but intact decision-making in Asperger syndrome: Implications for the relationship between these cognitive domains","resumen":"The relationship between decision making and theory of mind (TOM) has been hardly investigated in patients with Asperger Syndrome (AS). Here, we show that the AS group (n=25) exhibited deficits on a complex TOM task, yet were unimpaired in a decision-making test. No association was found between these two domains.","palabras_clave":"ASPERGER|DECISION MAKING|THEORY OF MIND|SOCIAL COGNITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1994,"idioma_id":5,"titulo":"Narrativas de la modernidad religiosa contemporánea: las nuevas tradiciones de lo antiguo","resumen":"Este trabajo analiza el modo en que movimientos religiosos contemporáneos recrean pasados históricos y tradiciones religiosas dentro de nuevos marcos organizacionales y cosmológicos, los que pueden verse como una crítica cultural a la modernidad que ellos experimentan como sujetos históricos. Desde una perspectiva antropológica, exploro los casos del neo-paganismo lituano, por una parte, y del culto brasileño del Santo Daime, por la otra. De esta forma, se identifican elementos clave de su imaginación religiosa, condensados en rituales, mitos y organización social, los que expresan una muy creativa reinvención de tradiciones. Argumento aquí que ésta implica una compleja reconstrucción simbólica del tiempo y del espacio en la cual las nuevas visiones de lo antiguo juegan un rol cultural y político central.","palabras_clave":"MODERNIDAD|RELIGIÓN|NEOPAGANISMO|SANTO DAIME"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1995,"idioma_id":5,"titulo":"La producción cultural del imaginario esotérico: una visita desde Buenos Aires","resumen":"En este trabajo, a partir de investigaciones de campo antropológicas, nos proponemos analizar tres instituciones que se ubican en posiciones periféricas del campo religioso argentino. Las características distintivas de estos grupos es que pueden catalogarse analíticamente como esotéricos, porque sus imaginarios y rituales se entroncan con tradiciones del hermetismo y ocultismo occidental, reelaborando ideas centrales del positivismo espiritualista del siglo XIX. Exploramos aquí los casos de la Escuela Científica Basilio, la Sociedad Teosófica y la Orden Rosacruz AMORC, profundizando especialmente en sus imaginarios, principales aspectos doctrinales, rituales, y presentación en el campo religioso. Identificamos así sus nociones de tiempo e historia que se vinculan con una concepción sacralizada de los orígenes de sus tradiciones, que pueden definirse como pertenencia remota. Asimismo, dentro de las maniobras de presentación pública en el campo religioso, identificamos formas de identidad precautoria, que aseguran su posición relativa en él, frente a los estigmas sociales que se tienen sobre lo esotérico, generados por los actores institucionales hegemónicos como la Iglesia Católica y otros cristianismos de raigambre protestante. La idea es hacer visibles a los estudios académicos de la religión, grupos e instituciones poco conocidos en el país, que expresan aspectos filosóficos, sociológicos y ontológicos de gran riqueza cultural.","palabras_clave":"IMAGINARIO|ESOTERISMO|RELIGIÓN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1996,"idioma_id":4,"titulo":"Stressful conditions experienced by endangered Egyptian vultures on African wintering areas.","resumen":"Among European breeding birds, those wintering in the Sahel region have undergone a sustained and severe decline. Long-term data show that variation in primary production of the Sahelian staging area significantly affects survival of many species, a relationship probably mediated by trophic resource availability. However, the physiological, hormonal and behavioural responses underlying this relationship remain unexplored. We present a potential explanation for the importance of prevailing conditions during winter to understand the population ecology and current trends of migratory species. We measured corticosterone levels in feathers of Egyptian vultures Neophron percnopterus grown in Africa and Europe, showing how conditions faced by birds during wintering periods result in the release of more corticosterone over time than when those individuals were on their summering grounds. This pattern was concordant with home-range size differences (c. 33 times larger in Africa than in Europe). We suggest that as wintering habitat of Egyptian vultures in the Sahel region has degraded during recent times, food availability has also been reduced. An increase in corticosterone during winter with a consequent increase in locomotor activity, for example, food searching behaviour, may normally be adaptive. However, enlarging home ranges could be futile if conditions are not better in the dispersal area, and costs of the higher corticosterone level, including energy expenditure from enhanced activity, may pose a significant trade-off. These physiological responses may be characteristic of other European trans-Saharan migrant birds that have undergone significant population declines.","palabras_clave":"CORTICOSTERONE|SAHEL REGION|TRANS-SAHARAN MIGRATORY SPECIES|WINTER MORTALITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1997,"idioma_id":5,"titulo":"La agricultura capitalista entre el campo y la ciudad. Estudio de dos casos en la región pampeana argentina","resumen":"Este artículo analiza las transformaciones ocurridas en la producción agropecuaria, la estructura agraria y las dinámicas poblacionales en el marco de la expansión económica protagonizada por la región pampeana argentina en las últimas décadas. La rentabilidad de los cultivos, los nuevos paquetes tecnológicos disponibles y las dinámicas propias de los territorios locales generaron cambios y nuevas relaciones entre lo rural y lo urbano. El estudio se realiza a través de la comparación de dos casos diferenciados, uno exponente de los procesos de ?sojización? en la región pampeana y otro expuesto a las dinámicas diversificadas del sector agropecuario y a la expansión urbana.","palabras_clave":"agricultura capitalista |región pampeana|estructura agraria|dinámica poblacional"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1998,"idioma_id":5,"titulo":"El archivo positivista como dispositivo visual-verbal. Fotografía, feminidad anómala y fabulación*","resumen":"En este trabajo se analiza el archivo como dispositivo visual y verbal, en el contexto del paradigma fuertemente hegemónico del positivismo argentino de comienzos del siglo XX. A través de los artículos que Francisco de Veyga publica entre 1902-1904 en los Archivos de Psiquiatría y Criminología acerca de sexualidades consideradas anómalas y las fotografías que ilustran estos 'casos', se indaga sobre algunas de las operaciones discursivas y no discursivas que el archivo -como un aparato psíquico de cuerpo social que se considera patógeno- presenta sobre el género, la 'feminidad anómala', la fotografía y la clasificación médico-psiquiátrica. Esta última se articula a partir de los ejes binarios normal\/patológico, pero también presenta resistencias vitales dentro del panóptico biopolítico y dentro de la lógica de generalización del archivo, a través de la fabulación y la mirada del otro.&nbsp;","palabras_clave":"ARCHIVO|POSITIVISMO|GÉNERO|FRANCISCO DE VEYGA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":1999,"idioma_id":4,"titulo":"Key differences on the compaction response of natural and glass fiber preforms in liquid composite molding","resumen":"In the present work, the effects of fiber structure and fluid absorption on the compaction behavior of jute woven fabrics and sisal mats were analyzed and compared with the response of glass fiber mats. It was found that the fiber content that can be achieved with a certain compaction pressure is lower in the case of natural fiber preforms. In addition, due to the hollow structure of these natural fibers, jute and sisal preforms suffered larger permanent deformation than glass fiber preforms after the compressive loading cycle. In addition, it was found that fluid absorption reduced the compaction pressure in natural reinforcements due to fiber softening. These phenomena were not observed in glass fiber mats.","palabras_clave":"COMPOSITES|NATURAL FIBERS|COMPACTION BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2000,"idioma_id":4,"titulo":"Child's personality and perception of parental relationship as correlates of optimal experience","resumen":"The study was designed to assess the influence of child?s personality and perception  of parental relationship on children?s optimal experiences. We proposed functional  and dysfunctional models to analyze the increase or the decrease of the children?s flow  experience. The sample of this study included 909 middle class children, aged 9?12  (M = 11.02, SD = 1.08), both sexes, from Argentina. When we analysed the psychological  factors that could be related to the flow state in childhood, we found out that the child?s  perception of a functional parental relationship, in which there is either acceptance or  moderate control, indirectly affects the flow experience, through child?s personality?  extraversion, openness to experience, and conscientiousness. Functional personality traits  have an important positive effect on optimal experience when they are considered as a unit.  In the dysfunctional model of flow, the results showed that the child?s perception of parental  pathological control had an important positive effect on neuroticism and ?through this?a  negative effect on flow. The child?s perception of parental negligence did not have a significant  effect on neuroticism; however, neuroticism still maintained its negative effect on  flow.","palabras_clave":"FLOW STATE|OPTIMAL EXPERIENCE|PERSONALITY|PARENTAL RELATIONSHIP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2001,"idioma_id":5,"titulo":"Revista de Extensióm de la Facultad de Odontología de La Plata","resumen":"La Extensión Universitaria, pilar conceptual e ideológico de la Universidad, junto a la enseñanza y la investigación, desarrolla y multiplica su actividad y su alcance, transitando quizás, su momento más importante.Los paradigmas de formación, integración y calidad que debe encarnar la Facultad de oOdontología y la aceleración de los procesos (tecnológicos, demográficos, urbanos, ambientales, sociales, productivos, económicos, etc.) en el país y en el mundo, instalan en ésta Casa de Altos Estudios, la necesidad de interpretar a la extensión en su sentido más amplio, involucrándola en los más diversos aspectos de vinculación con la sociedad y el medio, no sólo transfiriendo, sino y fundamentalmente escuchando, aprendiendo y reflexionando sobre el contenido de los mensajes. No es suficiente abrir las puertas de la Facultad al medio, no alcanza con ofrecer lo que sabemos hacer, ni con hacer lo que nos demandan; hoy la Facultad de Odontología debe hacer lo que es necesario. Es necesario salir y formar parte. El desafío es escuchar, integrar a la Facultad con la Sociedad e involucrarse para elaborar una respuesta útil y comprometida, no sólo con el futuro, sino con el presente.","palabras_clave":"EXTENSION|PREVENCION|ALUMNOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2002,"idioma_id":5,"titulo":"PLOMADAS DE REDES DE PESCA EN SAN JOSÉ DE FLORES","resumen":"El sitio Nazca 313 está ubicado en el barrio porteño de Flores. Se realizó una excavación de rescate al observar que el piso de un sector de la vivienda particular que constituye el sitio sufría un paulatino e irreversible deterioro. El rescate consistió en la excavación de una unidad de un metro cuadrado con una potencia de cuarenta y seis centímetros. Entre otros objetos metálicos se hallaron tres pesos para redes de pesca hechos de plomo puro. Estas plomadas se intercalaban en el entramado de las redes con el objetivo de mantenerlas hundidas mientras se efectuaba la pesca en el Río de la Plata. Nos proponemos integrar los datos históricos disponibles, en particular aquellos que traten sobre el mundo la pesca en la ciudad de Buenos Aires, con la evidencia material proporcionada por las metalografías ópticas realizadas sobre las piezas y su ulterior interpretación.","palabras_clave":"PESCA|PLOMADAS|METALOGRAFÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2003,"idioma_id":4,"titulo":"Ceramic technology and residential mobility in small scale groups of north Patagonia: Archeological cases from southern Mendoza","resumen":"The purpose or this paper is to analyse four ceramic assemblage sets and discuss the relationship betweenceramic investment, environment and strategies of mobility among Late Holocene hunter-gatherers in southernMendoza. The analysed assemblages come from the areas of Llancanelo, Atuel Medio, Rio Grande, and surfacematerials from Volcán Overo. Different attributes of the archaeological ceramic like wall thickness, temper size,and surface preparation, enable us to evaluate the residential mobility of local human populations. Trends withineach assemblage and among sets can be drawn from the study. Finally, the results point to heterogeneitybetween the relationship of the concept of investment in each locality and its implications for making inferencesabout hunter-gatherer mobility.","palabras_clave":"Ceramic technology,| mobility, |southern Mendoza,| north Patagonia,| hunter gatherers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2004,"idioma_id":4,"titulo":"Physico-chemical characteristics and pyrolysis behavior of Klason lignins isolated from agro-industrial biomass","resumen":"Klason lignins lab-isolated from two lignocellulosic biomasses emerging from the processing of agro-industrial products, Aspidosperma australe wood sawdust and Bertholletia excelsa nutshells, with different contents of lignin (27 and 57 wt%, respectively) are characterized. Characterization includes determination of ash content, elemental composition, Fouriertrans form infrared spectra, and surface morphological features by scanning electronic microscopy. Pyrolysis behavior of the isolated lignins as well as of the parent biomasses from which they are extracted is comparatively examined by non-isothermal thermogravimetric analysis from room temperature up to 1000 ºC. The lignins exhibit different ash contents and elemental compositions, as well as noticeable differences in their pyrolytic behavior depending on the botanical origin of the bio-resource and with respect to that determined for the untreated parent biomasses. Overall, the lignin isolated from the nutshells is more resistant to degrade than the sawdust-derived lignin likely due to a more condensed chemical structureAspidosperma australe wood sawdust and Bertholletia excelsa nutshells, with different contents of lignin (27 and 57 wt%, respectively) are characterized. Characterization includes determination of ash content, elemental composition, Fouriertrans form infrared spectra, and surface morphological features by scanning electronic microscopy. Pyrolysis behavior of the isolated lignins as well as of the parent biomasses from which they are extracted is comparatively examined by non-isothermal thermogravimetric analysis from room temperature up to 1000 ºC. The lignins exhibit different ash contents and elemental compositions, as well as noticeable differences in their pyrolytic behavior depending on the botanical origin of the bio-resource and with respect to that determined for the untreated parent biomasses. Overall, the lignin isolated from the nutshells is more resistant to degrade than the sawdust-derived lignin likely due to a more condensed chemical structure","palabras_clave":"KLASON LIGNINS|PYROLYSIS|BIOMASS|BIO-ENERGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2005,"idioma_id":5,"titulo":"Memoria y responsabilidad: una paráfrasis ética (la escritura de Héctor Schmucler)","resumen":"Todo trabajo sobre la memoria implica un desafío. Este desafío se torna emblemático cuando, además, no sólo se analizan la sociedad concentracionaria en Argentina (1976-1982) y la violencia política que la antecedió, sino, fundamentalmente, esta reflexión es ejercida por un intelectual que asume su responsabilidad frente a lo acontecido y hacia los otros. Una cuestión ética, que Foucault definió cuando dijo \u201CNo se puede hacer ni la historia de los reyes ni la de los pueblos, sino la historia de lo que constituye esos dos términos uno frente al otro, de los cuales uno nunca es el infinito y el otro nunca es cero\u201D (Foucault 2008:158). El \u201Cotro\u201D como práctica y develación de la responsabilidad, el \u201Cotro\u201D desaparecido, suprimido de la vida es el tema que analizamos en los escritos de Héctor Schmucler en una serie de escritos producidos entre 1979 y 2005. La matriz discursiva que enmarca esta indagación se centra en el trabajo de paráfrasis desplegado por Schmucler. La paráfrasis, en este caso una auto-reformulación que amplía sentidos e ilumina vacíos, es señalada, por la tarea de hacer memoria, como una estrategia modeladora para producir una palabra que asume su compromiso y su duelo. El don de la reformulación encauza, como sostiene Levi, el hecho de sobrevivir, para contarlo, para dar testimonio (Levi 2002: 21) ","palabras_clave":"memoria|discurso intelectual |paráfrasis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2006,"idioma_id":4,"titulo":"Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia 4 blainvillei, from Argentina","resumen":"Metallothioneins are signals of metal exposure and widely used in biomonitoring. Franciscana dolphin is 29  an endemic cetacean from the Southwestern Atlantic Ocean, classified as Vulnerable A3d by the IUCN. 30  Metallothionein, copper and zinc in Franciscana were assessed in two geographic groups; one inhabits 31  La Plata River estuary, anthropogenically impacted, and the other inhabits marine coastal ecosystems, 32  with negligible pollution. Despite the environment, hepatic and renal MT concentrations were similar, 33  but there was a declining trend from early to later developmental stages. Metallothionein K\/L, Cu and 34  Zn levels corresponded to normal reported ranges. MT was not related with Cd. Fetal concentrations were 35  higher than its mother. These results and the health status of dolphins are suggesting that MT correspond 36  to physiological ranges for the species, and they are closely to homeostasis of Zn and Cu, according to its 37  ontogenetic changes. The information constitutes the first MT information on Franciscana dolphin and 38  can be considered as baseline for the species conservation.","palabras_clave":"P.blainvillei|Metallothioneins|Biomarker|Ontogeny"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2007,"idioma_id":4,"titulo":"Frictional resistance exerted by different lingual and labial brackets: an in vitro study.","resumen":"Abstract  Background: Although much has been written on the implications of friction generated between orthodontic archwires and labial brackets, information on lingual brackets is still limited. Hence, we set out to investigate the  frictional resistance exerted by different lingual and labial brackets, including both conventional and self-ligating designs. The effect of various factors, namely bracket\/base width, slot size, inter-bracket distance, and first- (&#920;cI) and second-order (&#920;cII) critical contact angles were evaluated and compared.  Methods: A plaster model of a pretreatment oral cavity was replicated to provide 18 (9 upper and 9 lower) identical versions. The anterior segments of each were taken, and the canine and lateral and central incisors were  mounted with either lingual (7th Generation, STb, New STb, In-Ovation L, ORJ) or labial (Mini-Mono, Mini Diamond, G&H Ceramic) brackets. Mechanical friction tests were performed on each type of bracket using a universal testing  machine. The maximum force necessary to displace NiTi wires of two different diameters (0.012, 0.014) was measured, using both elastic and metal ligatures with conventional brackets.  Results: The frictional force necessary to displace the wires increased as the diameter of the wire increased in all tested brackets (p < 0.01). Friction was significantly higher (p < 0.001) with elastic ligatures, as compared with metal  ones, in all conventional brackets. In the lower lingual group, significantly lower friction was generated at conventional lingual New STb brackets (p < 0.01) and ORJ lingual brackets (p < 0.05) than at self-ligating In-Ovation  L lingual brackets. A significant statistical correlation between (&#920;cI) and friction was detected in the lower labial bracket group.  Conclusions: Friction resistance is influenced not only by the bracket type, type of ligation, and wire diameter but also by geometric differences in the brackets themselves.","palabras_clave":"Orthodontics|Brackets"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2008,"idioma_id":5,"titulo":"La utilización de herramientas de TICS como apoyo al proceso de articulación con el nivel medio. La experiencia de la Facultad de Ciencias Económicas de la UNER.","resumen":"La Facultad de Ciencias Económicas de la Universidad nacional de Entre Ríos ofrece las carreras de Grado de Contador Público y Licenciado en Economía.Desde el año 2002 se comenzó a desarrollar el ?Programa de Articulación Nivel  Medio ?Universidad? , el que a partir de una concepción amplia, se define como el desarrollo de acciones, tanto docente como de extensión hacia el medio, tendentes a generar instancias de encuentro entre ingresantes y universidad.Como consecuencia de ello los destinatarios son los estudiantes del último año de los establecimientos educativos del nivel medio, pero también los docentes que se desempeñan en ellos cuyo objetivos generales son los de mejorar las condiciones de la transición entre la escuela secundaria y los organismos de enseñanza superior, la divulgación de las carrera que se dictan en la Facultad y la presencia de la Universidad Pública en Entre Ríos.Todos los años el equipo docente a cargo de los cursos junto a la gestión académica y de extensión de la facultad efectúa un análisis de lo acontecido y propone mejoras y nuevas acciones.En este sentido se considera que en la medida que las prácticas institucionales y docentes han sido innovadoras y se abordan siguiendo el  lineamiento del paradigma de la enseñanza activa se han logrado los mejores resultados y bajo este paradigma debe estar presente siempre un apoyo en la TICs.Asi es como a partir del año 2010, se implementa un curso virtual de articulación que se tomó como complemento del curso presencial y en basamento como opción a distancia.Este trabajo pretende destacar la importancia de la TICs, la experiencia alcanzada por el programa ?Articulación Nivel  Medio ? Universidad? de la Facultad de Ciencias Económicas de la Universidad Nacional de entre Ríos a su más de diez  años de creación y el acompañamiento de la virtualización del mismo.","palabras_clave":"TICS|ARTICULACIÓN NIVEL MEDIO - UNIVERSIDAD|E-LEARNING|ENSEÑANZA ACTIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2009,"idioma_id":4,"titulo":"Uncobasidium roseocremeum sp. nov. and other corticioid basidiomycetes from the Patagonian Andes of Argentina.","resumen":"  Eighteen corticioid species are reported as new from the Patagonian Andes of Argentina, most of them new records for South America or for the southern hemisphere. Comments are included for all species with illustrations provided for some. Uncobasidium roseocremeum is described as new and a key to the accepted Uncobasidium species is included.   ","palabras_clave":"CEROCORTICIUM|CORTICIACEAE|GLOBULICIOPSIS|GLOBULICIUM|WOOD-INHABITING FUNGI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2010,"idioma_id":4,"titulo":"Characterization and health risk assessment of VOCs in occupational environments in Buenos Aires, Argentina","resumen":"To detect volatile organic compounds (VOCs) in indoor air in small enterprises in La Plata city and surrounding areas, sampling was conducted using passive diffusion monitors (3M-3500) and&nbsp; analysis of the samples were performed by &nbsp;CG-FID. Analytic methodology was optimized for 23 VOCs (n-alkanes, cycloalkanes, aromatic and chlorinated compounds, ketones and terpenes compounds) by determining the recovery factor and detection limit for each analyte. Different recovery values were obtained by desorbing with a mixture of dichloromethane: methanol (50:50), with a standard deviation lower than 5%. Enterprise analyzed included chemical analysis laboratories, sewing workrooms, electromechanical repair and car painting centers, take away food shops, and a photocopy center. The highest levels of VOCs were found to be in electromechanical repair and car painting centers (hexane, BTEX, CHCl3, CCl4) followed by chemical analysis laboratories and sewing workrooms. Cancer and noncancer risks were assessed using conventional approaches (HQ and LCR, US EPA) using the benzene, trichloroethylene, chloroform for cancer risk, and toluene, xylene and n-hexane, for noncancer risks as markers. The results showed different LCR for benzene and trichloroethylene between the different indoor environments analyzed (electromechanical repair and car painting center &gt;&gt; others) and chloroform (laboratory &gt; others), but comparing with the results obtained by other research, are in similar order of magnitude for equivalents activities.&nbsp; Similar finding were founded for HQ. ","palabras_clave":"Monitoring|VOCs|Recovery factor|Indoor air quality"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2012,"idioma_id":4,"titulo":"Mitochondrial and nuclear markers reveal a lack of genetic structure in the entocommensal nemertean Malacobdella  arrokeana in the Patagonian gulfs","resumen":"                                          Malacobdella arrokeana is an entocommensal nemertean exclusively found  in the bivalve geoduck Panopea abbreviata, and it is the only  representative of the genus in the southern hemisphere. To characterize its  genetic diversity, population structure and recent demographic history, we  conducted the first genetic survey on this species, using sequence data for the  cytochrome oxidase I gene (COI), 16S rRNA (16S) and the internal transcribed  spacer (ITS2). Only four different ITS2 genotypes were found in the whole  sample, and the two main haplotypes identified in the mitochondrial dataset  were present among all localities with a diversity ranging from 0.583 to 0.939.  Nucleotide diversity was low (&#960; = 0.001-0.002). No significant genetic structure was detected between  populations, and mismatch distribution patterns and neutrality tests results  are consistent with a population in expansion or under selection. Analysis of  molecular variance (AMOVA) revealed that the largest level of variance observed  was due to intrapopulation variation (100, 100 and 94.39 % for 16S, COI and  ITS2, respectively). F st values were also non significant. The observed lack  of population structure is likely due to high levels of genetic connectivity in  combination with the lack or permeability of biogeographic barriers and  episodes of habitat modification.                              ","palabras_clave":"NEMERTEAN|ENTOCOMMENSAL|GEODUCK|GENETIC VARIATION|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2013,"idioma_id":4,"titulo":"Yeast mutator phenotype enforced by Arabidopsis PMS1 expression","resumen":"The DNA mismatch repair (MMR) system is a major DNA repair pathway whose function is critical for the correction of DNA biosynthetic errors. MMR is initiated by the binding of MutS proteins to mismatches and unpaired nucleotides followed by the recruitment of MutL proteins. The major MutL activity in eukaryotes is performed by MutLa, the heterocomplex of&nbsp; MLH1-PMS1 in yeast and plants and MLH1-PMS2 in humans. We here report the effect the expression of Arabidopsis PMS1 protein exerts on Saccharomyces cerevisiae genomic stability. A strain carrying specific microsatellite instability reporter systems was chosen for the study. The plant protein failed to complement the hypermutator phenotype of a pms1 deficient strain but increased approximately 14-fold and 2,000-fold the mutation rates of his7-2 and lys2::InsEA14loci of MMR proficient strains when compared to wildtype strains, respectively. Overexpressing AtMLH1 in the AtPMS1-overproducing strain generated an increase in mutation rate comparable to that of AtPMS1 expression alone. Deletion of the C-terminal residues implicated in protein\/protein interaction and including the putative endonuclease sequence of AtPMS1 completely&nbsp; eliminated the mutator phenotype. Taken together, these results indicate that the plant proteins affect yeast genomic stability, very possibly altering protein?protein interactions that arenecessary to complete repair. ","palabras_clave":"Mismatch repair|Microsatellite instability|Mutation rate|Arabidopsis thaliana|Saccharomyces cerevisiae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2014,"idioma_id":4,"titulo":"Genetic diversity assessment and genotype identification in sugarcane based on DNA markers and morphological traits","resumen":"Sugarcane is known for its highly complex genetics and more knowledge is needed for better use and conservation of genetic materials. In order to identify genotypes and to assess genetic diversity, diverse data sets such as morphological and molecular markers are used as a general approach. To evaluate the usefulness of different markers, important sugarcane genotypes in Argentina were characterized by AFLP, SSR and morphological traits. All genotypes characterized were grouped in one main cluster in dendrograms using two independent softwares. Interestingly, local genotypes grouped together with USA varieties and no clear genetic differentiation could be found probably due to intensive germplasm exchange between these breeding programs. The molecular markers tested were useful for genetic diversity assessment as well as for genotype identification. These markers should be included in the internationally established characters for sugarcane variety protection as they give a better view on whole genome complexity. Additionally, genetic similarities obtained from molecular markers will provide more accurate information to breeders than the pedigree method, especially when considering the asymmetric genetic inheritance of sugarcane. Morphological traits are valuable tools to identify genotypes since they reflect external resemblance more than genetic relatedness. When they were combined with molecular markers the dendogram obtained revealed genetic relationships and the genetic diversity was better estimated. In summary, both methods appear to be useful, complementing each other and should be used together to assist sugarcane breeders in estimating genetic diversity, electing parents for crossings, identifying superior lines and to protect intellectual property rights.","palabras_clave":"Breeding program |Sugarcane germplasm bank|Morphological descriptors | Similarity coefficient"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2015,"idioma_id":5,"titulo":"Tritrichomonas foetus: mecanismos de acción patógena","resumen":"Tritrichomonas foetus es un protozoario flagelado que afecta al ganado bovino siendo responsable de la Trichomonosis genital bovina, enfermedad de transmisión venérea con infertilidad y abortos , la cual causa grandes pérdidas económicas en muchos países del mundo incluyendo a la Argentina. En la presente revisión se resumen la información vinculada al mecanismo de  acción patógena y factores de virulencia del protozoario.","palabras_clave":"TRITRICHOMAS FOETUS|ACCIÓN PATÓGENA |TRICHOMONOSIS GENITAL BOVINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2016,"idioma_id":5,"titulo":"Bolívar, la guerra social y el pueblo en armas","resumen":"En este artíuclo el autor intenta desentrañar los cambios de concepción estratégica que se fueron produciendo en las guerras de independencia latinoamericana tomando como base central de su análisis histórico a Simón Bolivar y su relación con la liberación de los esclavos (1816) y la transformación de la guerra nacional en una guerra de liberación anticolonial y social basada en el pueblo en armas. REVISTA CON REFERATO DOBLE CIEGO (PAR 20\/21: SISTEMA DE ARBITRAJE CON EVALUADORES EXTERNOS)","palabras_clave":"Guerra social|Esclavitud|Pueblo en Armas|Colonialismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2017,"idioma_id":5,"titulo":"La microhistoria como referente teórico-metodológico. Un recorrido por sus vertientes y debates conceptuales","resumen":"El artículo hace una contribución historiográfica sobre la microhistoria como vertiente teórico epistemológica, de tal manera que la ubica en su contexto de surgimiento, recorre sus principales referentes e incursiona en sus lineamientos metodológicos y conceptuales. Se repasan los debates que atravesó la corriente con respecto a cuestiones tales como la representatividad de los casos de estudio, el tema de relativismo, la original apreciación de un contexto, así como los límites y los riesgos del análisis micro. Asimismo se incursiona en las complejas derivas de la racionalidad individual y de la autonomía relativa que suponen los actores sociales; para terminar ingresando en la fructífera relación entre microhistoria e historia local.Revista indexada en: DOAJ, Latindex, Dialnet, ISOC, DICE, E-revist@s, CIRC, Resh, IN-RECH.","palabras_clave":"TEORÍA|METODOLOGÍA|HISTORIOGRAFÍA|MICROHISTORIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2020,"idioma_id":5,"titulo":"Megalobulimus sanctipauli (Ihering y Pilsbry, 1900): antecedentes de la especie","resumen":"sin resumenMegalobulimus sanctipauli (Ihering y Pilsbry, 1900): (Ihering y Pilsbry, 1900):antecedentes de la especie","palabras_clave":"MEGALOBULIMULUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2021,"idioma_id":5,"titulo":"TICs y Difusión del Patrimonio Cultural. Realidad Aumentada y Virtual en el Área Fundacional de Bahía Blanca","resumen":"La ciudad de Bahía Blanca cuenta con diferentes áreas de valor patrimonial, dentro de  las cuales se destaca su casco fundacional. Dada su importancia en el proceso de  desarrollo y consolidación del centro urbano, resulta relevante establecer estrategias que  contribuyan a la valorización de sus componentes patrimoniales.  En este contexto, las nuevas tecnologías aplicadas al turismo, permiten un mejor  acceso y mayor acercamiento a estos bienes culturales, convirtiéndose en herramientas  elementales para su difusión.  La Realidad Aumentada y Virtual se visualizan como dos nuevas tecnologías  importantes para el tipo de difusión planteado, ya que posibilitan un acercamiento a los  bienes patrimoniales, de forma atractiva y diferente a los medios convencionales de  impulsión ya conocidos.  A partir de lo expresado, se ha planificado un trabajo articulado entre el  Departamento de Geografía y Turismo y el Departamento de Ciencias e Ingeniería de la  Computación, ambos pertenecientes a la Universidad Nacional del Sur, y la Dirección  General de Asuntos Turísticos y Relaciones Internacionales, de la Municipalidad de  Bahía Blanca.  La ponencia tiene como objetivo: contribuir a la difusión del patrimonio  arquitectónico y urbano del área fundacional de Bahía Blanca, mediante la  implementación de las nuevas tecnologías aplicadas al turismo, como la Realidad  Aumentada y Virtual.  Para la consecución del objetivo planteado, en primera instancia, se especifica el  procedimiento mediante el cual se aborda la investigación. A continuación, dentro del  marco conceptual, se desarrollan los temas clave que dan sustento teórico a las  iniciativas que se llevan a cabo. Posteriormente, se especifican las propuestas  resultantes del trabajo. Las mismas se presentan de forma ordenada, por programas y  proyectos.  A partir de las estrategias y acciones turístico-recreativas planteadas, orientadas a  visitantes y residentes de la ciudad de Bahía Blanca, se pretende contribuir a una mayor  valorización del patrimonio cultural local, a través de la implementación de las nuevas  tecnologías aplicadas al turismo, que se transforman en una alternativa para su difusión,ampliando la accesibilidad, información y contacto de los usuarios para con los bienes  patrimoniales.","palabras_clave":"Patrimonio Cultural|Nuevas Tecnologías|TICs|Realidad Virtual y Aumentada"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2022,"idioma_id":4,"titulo":"Cognition and Vascular Risk Factors: An Epidemiological Study","resumen":"We conducted an epidemiological approach to identify the negative impact of the vascular risk factors (such as hypertension, diabetes and hypercholesterolemia) over cognition. The interesting aspect of this study was that the survey was conducted in all age groups through a voluntary call (n = 1365; &#8805;18 years old, both sexes; age 49 ± 15 y, female 75.7%). Thus, we demonstrated that the use of a Minimum Cognitive Examination (MCE), a brief, simple, and easy managed neuropsychological evaluation, detected a greater number of people with cognitive decline surpassing to the Minimal Mental Statement Examination alone (14.5% of the participants showed MMSE &#8804;24, 34,6% showed dys-executive function, and 45,8% memory impairment. Out of the 4 studied RF,the only one that was not related to cognitive impairment was dyslipemia. Finally, we noted the importance of cognitive state early detection in all age groups, even in the youngest group. Acting in the middle of the life stages, we can prevent or delay the onset of a disease in adults, nowadays incurable: dementia.","palabras_clave":"COGNITION|VASCULAR|EPIDEMIOLOGICAL STUDY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2029,"idioma_id":4,"titulo":"Influence of the irradiance on phenols content and rooting of Ilex paraguariensis cuttings collected from adult plants","resumen":"The influence of irradiance on phenolics contentsand rooting of Ilex paraguariensis cuttings wasstudied. Results of the first experiment with stock plantsunder controlled-irradiance conditions show that when theirradiance level increased from 1.5 to 100 % PPFD, theoxidation of cuttings raised from 19 ± 11 to 88 ± 4 %(r2 = 0.64). At the same time, a strong correlation wasobserved between total phenolics content and irradiance(r2 = 0.7). In consequence, adventitious rooting diminishedfrom 67 ± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisIlex paraguariensis cuttings wasstudied. Results of the first experiment with stock plantsunder controlled-irradiance conditions show that when theirradiance level increased from 1.5 to 100 % PPFD, theoxidation of cuttings raised from 19 ± 11 to 88 ± 4 %(r2 = 0.64). At the same time, a strong correlation wasobserved between total phenolics content and irradiance(r2 = 0.7). In consequence, adventitious rooting diminishedfrom 67 ± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensis± 11 to 88 ± 4 %(r2 = 0.64). At the same time, a strong correlation wasobserved between total phenolics content and irradiance(r2 = 0.7). In consequence, adventitious rooting diminishedfrom 67 ± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisr2 = 0.64). At the same time, a strong correlation wasobserved between total phenolics content and irradiance(r2 = 0.7). In consequence, adventitious rooting diminishedfrom 67 ± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisr2 = 0.7). In consequence, adventitious rooting diminishedfrom 67 ± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensis± 5 to 3 ± 3 % under full radiation(r2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisr2 = 0.7). In the second experiment with stock plantssubjected to field conditions, the results showed that therooting process is strongly affected by the genotype(P\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisP\\0.0001), while the statistical analysis did not show acorrelation between rooting and age of the donor plant.Season had a variable effect and depends on genotype.Although we did not find correlations between the rootingability and the canopy structure of the stock plants, theposition of the branches in the mother plant affectedrooting and depended on season in addition to genotype.Concomitantly, the levels of soluble phenolics compoundswere higher from leaves subjected to high-irradiance conditionsthan samples collected from inner canopy; whichwas coincident with the pattern of cuttings oxidation. Inconclusion, our results provide evidences which supportthe hypothesis that the physiological status of the stockplant at the time that cuttings are excised is of utmostimportance for the subsequent rooting of I. paraguariensisI. paraguariensiscuttings. The influence on soluble phenolics content ofdifferent irradiances given to the stock plants negativelyaffect the rooting process since the product of its oxidationcause the browning and death of the cuttings.","palabras_clave":"Ilex paraguariensis |Stock Plant|Adventitious rooting |Soluble phenolics content"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2031,"idioma_id":4,"titulo":"Description of Atmospheric Conditions at the Pierre Auger Observatory  using the Global Data Assimilation System (GDAS)","resumen":"Atmospheric conditions at the site of a cosmic ray observatory must be known for reconstructingobserved extensive air showers. The Global Data Assimilation System (GDAS) is a global atmosphericmodel predicated on meteorological measurements and numerical weather predictions. GDAS providesaltitude-dependent profiles of the main state variables of the atmosphere like temperature, pressure,and humidity. The original data and their application to the air shower reconstruction of the Pierre AugerObservatory are described. By comparisons with radiosonde and weather station measurements obtainedon-site in Malargüe and averaged monthly models, the utility of the GDAS data is shown.","palabras_clave":"Atmospheric monitoring|Atmospheric models|Extensive air showers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2032,"idioma_id":4,"titulo":"Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress","resumen":"The extension of processes of oligodendrocyte (OLG) and their precursor cells are crucial for migration, axonal contact and myelination. Here we show that a non-lethal oxidative stress induced by 3-nitropropionic acid (3-NP) elicited a rapid shortening of processes (~24%) in primary OLGs and in oligodendroglial cell line (OLN-93) cells (~36%) as compared with vehicle-exposed cells. This was reversible and prevented by antioxidants. Proteomics of OLG lysates with and without 3-NP treatment yielded collapsin response mediator protein 2 (CRMP-2) as a candidate effector molecule. Inhibition of rho kinase was sufficient to prevent process retraction in both OLGs and OLN-93 cells. Oxidative stress increased phosphorylation of CRMP-2 at T555 that was completely prevented by Y27632. Moreover, transfection of OLN-93 cells with the mutant CRMP-2 T555A which cannot be phosphorylated by rho kinase, prevented process shortening induced by 3-NP as compared with wild-type CRMP-2. Our results suggest a role for endogenous reactive oxygen species in a pathway that regulates OLG process extension. The vulnerability of late myelinated neurons in the adult brain and the presence of white matter pathology in human dementias warrant the study of this oligodendroglial pathway in the early stages of neurodegenerative conditions characterized by oxidative stress.","palabras_clave":"OLIGODENDROCYTES|OXIDATIVE STRESS|CRMP2|ALZHEIMER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2033,"idioma_id":4,"titulo":"Vitellogenin levels in hemolymph, ovary and hepatopancreas of the freshwater crayfish Cherax quadricarinatus (Decapoda: Parastacidae) during the reproductive cycle'.","resumen":"The freshwater crayfish Cherax quadricarinatus is a tropical species of great interest for aquaculture.  Vitellogenin (Vg), a lipoprotein precursor of the vitellum accumulated in spawned eggs, can be synthesized  in the ovary and\/or hepatopancreas of most crustaceans, being the hemolymph the way for transporting Vg  throughout the reproductive cycle. Concentration of Vg in hemolymph, ovary and hepatopancreas of Cherax  quadricarinatus adult females was measured by means of ELISA, specifically developed after purifying the  native Vg. Measurements were made at four periods of the reproductive cycle: pre-reproductive, mid-reproductive,  late reproductive and post-reproductive. Besides, both hepatosomatic (HSI) and gonadosomatic (GSI)  indexes were determined in each period. Significant variations in Vg levels were detected in both hemolymph  and hepatopancreas, being the highest values observed during the mid-reproductive period. Besides, such variations  were positively correlated to the HSI. A positive correlation between Vg levels in hepatopancreas and  ovary was also seen. These results support previous evidences about the central role of the hepatopancreas as a  site of Vg synthesis in the studied species, together with the relevancy of hemolymph for transporting Vg from  the hepatopancreas to the ovary. For aquaculture purposes, Vg monitoring in hemolymph could be used as a  non-injurious method, to check the reproductive activity of C. quadricarinatus females. Rev. Biol. Trop. 60 (1):  253-261. Epub 2012 March 01.","palabras_clave":"CRUSTACEANS|REPRODUCTION|VITELLOGENIN|REPRODUCTIVE CYCLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2040,"idioma_id":4,"titulo":"Bone modification and destruction patterns of leporid carcasses by Geoffroy?s cat (Leopardus geoffroyi): An experimental study","resumen":"This paper characterizes the bone modification patterns on leporid carcasses  generated by captive Geoffroy?s cats (Leopardus geoffroyi). The modification  pattern from non-ingested remains is described in terms of anatomical  representation, breakage, and tooth marks. Results from this experimental study  suggest that Geoffroy?s cat tends to mostly destroy ribs and vertebrae. A high  proportion of fractures were registered in the scapulas, cranium, and the  epiphysis of long bones. The innominate, scapula, mandible, and long bones  showed high frequencies of tooth marks, dominated by pits and punctures. If the  activity of this particular predator is identified in fossil assemblages, the  differential inter- and intrabone survival produced by this agent on small mammal  prey should be taken into consideration when discussing anatomical part  representation.","palabras_clave":"LEOPARDUS GEOFFROYI|BONE MODIFICATION|EXPERIMENTAL STUDY|LEPORID CARCASSES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2042,"idioma_id":4,"titulo":"A fast method for measuring nanometric displacements by correlating speckle interferograms","resumen":"A phase evaluation method was recently proposed to measure nanometric displacements by means of digital speckle pattern interferometry when the phase change introduced by the deformation is in the range [0, pi) rad. To evaluate the phase change, however, it is necessary to record separately the intensities of the object and the reference beams corresponding to both the initial and the deformed interferograms. This paper presents a fast approach that overcomes this limitation. The rms phase errors introduced by the proposed method are determined using computer-simulated speckle interferograms and its performance is also compared with the results obtained with a phase-shifting technique. An application of the proposed phase retrieval method to process experimental data is finally illustrated.","palabras_clave":"Speckle interferometry|Phase evaluation|Order statistics correlation coefficient|Nanometric displacements"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2048,"idioma_id":4,"titulo":"Different levels of taxonomic resolution in bioassessment: a case study of oligochaeta in lowland streams","resumen":"Abstract: Aim: This study evaluated the use of oligochaetes at different levels of taxonomic resolution as environmental indicators in Argentine lowland streams affected by different land uses. Methods: Sampling sites were grouped based on the physicochemical and habitat characteristics (low-, moderate-, and high-impact disturbance). Collection of the oligochaetes samples was carried out seasonally in sediment and vegetation habitats. Results: The increases in nutrients and organic matter produced elevated densities of the Oligochaeta, but when the disturbance also involved changes in the physical habitat or enhancements in toxic substances, the abundance decreased significantly to values even lower than those of non-impacted environments. The responses of Naidinae and Tubificinae were similar. The density of the Pristininae decreased with increasing impact, but those of the Enchytraeidae and Rhyacodrilinae increased at the most highly impacted sites. The Opistocystidae were not recorded in high-impact sites. Species richness and diversity (H?) were lower in high-impact sites and even lower in sediments. Some species presented no restrictions in the habitat type or with the contamination level: Limnodrilus hoffmeisteri, Dero furcatus, D. digitata, D. pectinata, Pristina longiseta, and P. aequiseta. Moreover, Trieminentia corderoi, Slavina appendiculata, and Aulodrilus pigueti exhibited the highest abundances at low-impact sites and were not registered in high impact sites. Conclusions: The Oligochaeta show a relatively wide ecological valence through their extensive number of species. Although lower taxonomic levels can give information about environmental status, test-species? sensitivities to different types and degrees of contamination will be of utmost relevance to the evaluation of ecological quality.","palabras_clave":"ANNELIDS|LAND USE|HABITAT PREFERENCES|MACROPHYTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2051,"idioma_id":4,"titulo":"Tolerance to lipopolysaccharide promotes an Enhanced Neutrophil Extracellular Traps formation leading to a more efficient bacterial clearance in mice","resumen":"Tolerance to lipopolysaccharide (LPS) constitutes a stress adaptation, in which a primary contact with LPS results in a minimal response when a second exposure with the same stimulus occurs. However, active important defence mechanisms are mounted during the tolerant state. Our aim was to assess the contribution of polymorphonuclear neutrophils (PMN) in the clearance of bacterial infection in a mouse model of tolerance to LPS. After tolerance was developed, we investigated in vivo different mechanisms of bacterial clearance. The elimination of a locally induced polymicrobial challenge was more efficient in tolerant mice both in the presence or absence of local macrophages. This was related to a higher number of PMN migrating to the infectious site as a result of an increased number of PMN from the marginal pool with higher chemotactic capacity, not because of differences in their phagocytic activity or reactive species production. In vivo, neutrophils extracellular trap (NET) destruction by nuclease treatment abolished the observed increased clearance in tolerant but not in control mice. In line with this finding, in vitro NETs formation was higher in PMN from tolerant animals. These results indicate that the higher chemotactic response from an increased PMN marginal pool and the NETs enhanced forming capacity are the main mechanisms mediating bacterial clearance in tolerant mice. To sum up, far from being a lack of response, tolerance to LPS causes PMN priming effects which favour distant and local anti-infectious responses.","palabras_clave":"NEUTROPHILS|BACTERIAL CLEARANCE|ENDOTOXIN|ENDOTOXIN AND CLEARANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2057,"idioma_id":4,"titulo":"Highly Efficient Dehydrogenation of 5-Benzyl-3-phenyl-2-thioxoimidazolidin- 4-one: Microwave versus Flash Vacuum Pyrolysis Conditions","resumen":"5-Benzyl-3-phenyl-2-thioxoimidazolidin-4-one underwent thermal dehydrogenation to afford 5-benzylidene-2-thioxoimidaxolidin-4-one under microwave and flash vacuum pyrolysis conditions. A high predominance of the Z-isomer over the E-isomer of the imidazolidinone product was achieved. By using DFT and NBO calculations, the mechanism of the dehydrogenation and the selectivity were also explored.    ;Flash pyrolysis;Microwave chemistry;Reaction mechanisms","palabras_clave":"DEHYDROGENATION|PYROLYSIS|MICROWAVE|MECHANISMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2058,"idioma_id":4,"titulo":"Preischemic efferent vagal stimulation increases the size of myocardial infarction in rabbits. Role of the sympathetic nervous system","resumen":"ABSTRACT Background: Exogenously administered acetylcholine activates ischemic preconditioning, whereas prolonged vagal nerve stimulation (VNS) reduces mortality secondary to chronic heart failure. However, with respect to the effects of VNS applied before ischemia, there are no conclusive data on myocardial infarction in vivo. The aim of this work was to evaluate the effects of preischemic VNS on acute myocardial infarction in rabbits. Methods: Coronary artery was ligated for 45 min followed by 4 h of reperfusion (Group 1, control; n=14). Group 2 (n=9) received the same protocol as Group 1, except that, before ischemia, it received right efferent VNS for 10 min followed by 5 min of recovery. Group 3 (n=5) received the same protocol as Group 2, but atropine was administered during VNS. Group 4 (n=6) received the same protocol as Group 2, but atenolol, a &#946;1-adrenergic blocker, was administered. Group 5 (n=4) received atenolol during ischemia and reperfusion, but VNS was not performed. Group 6 (n=5) received the same protocol as group 2 but reserpine was administered 24 hs before VNS. Group 7 (n=4) received reserpine, but VNS was not performed. Results: Preischemic VNS increased the infarct size from 45.2 ± 2.4 in group 1 to 62.9 ± 3.1% in group 2 (p <0.05), whereas atropine reversed this effect, reducing it to 44.8 ± 3.9% (p <0.05 vs. Group 2). Atenolol administration in the presence of VNS decreased infarct size to 48.5 ± 2.8% (p <0.05 vs. Group 2). Reserpine abolished the deleterious effect of VNS on infarct size (44.0± 2.6%). Conclusion: Preischemic efferent vagal stimulation significantly increased infarct size by a muscarinic cholinergic mechanism, and a possible co-activation of sympathetic nervous system. Keywords: Myocardial infarction, vagal stimulation, atropine, atenolol.","palabras_clave":"MYOCARDIAL INFARCTION| VAGAL STIMULATION|CATECHOLAMINES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2061,"idioma_id":4,"titulo":"Glatiramer acetate reverts stress-induced alterations on adult neurogenesis and behavior. Involvement of Th1\/Th2 balance","resumen":"Long-term exposure to stressful situations has deleterious effects on adult neurogenesis, behavior, and the immune system. We have previously shown that stressed BALB\/c mice show poor learning performance, which correlates with an increase in the T helper 1\/T helper 2 (Th1\/Th2) cytokine balance. Glatiramer acetate (GA) can stimulate autoreactive T cells. In this work we investigated the effects of GA treatment on BALB\/c mice exposed to chronic mild stress (CMS). Stressed mice exhibited a significant decline in their performance in the open field and Y-maze tasks, which was accompanied by a reduction in dentate gyrus neurogenesis and an altered Th1\/Th2 balance. Interestingly, after 6&nbsp;weeks of CMS exposure administration of GA reestablished normal levels of adult neurogenesis, restored the Th1\/Th2 balance, and improved learning performance. These results demonstrate that GA treatment can reverse the learning impairment induced by stress through a mechanism that likely involves the regulation of the cytokine balance and adult neurogenesis.","palabras_clave":"Chronic mild stress| Cognitive deficit| Hippocampus| Glatiramer acetate| Cytokine balance|  Neuronal plasticity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2063,"idioma_id":4,"titulo":"Isolation of  Paenibacillus sp. and Variovorax sp. strains from decaying woods and characterization of their potential for cellulose deconstruction","resumen":"Prospection of cellulose-degrading bacteria in natural environments allows the identification of novel cellulasesand hemicellulases that could be useful in second-generation bioethanol production. In this work, cellulolyticbacteria were isolated from decaying native forest soils by enrichment on cellulose as sole carbon source. Therewas a predominance of Gram positive isolates that belonged to the phyla Proteobacteria and Firmicutes. Manyprimary isolates with cellulolytic activity were not pure cultures. From these consortia, isolation of pure constituentswas attempted in order to test the hypothesis whether microbial consortia are needed for full degradation ofcomplex substrates. Two isolates, CB1-2-A-5 and VG-4-A-2, were obtained as the pure constituents of CB1-2 andVG-4 consortia, respectively. Based on 16S RNA sequence, they could be classified as Variovorax paradoxus andPaenibacillus alvei. Noteworthy, only VG-4 consortium showed measurable xylan degrading capacity and signs offilter paper degradation. However, no xylan or filter paper degrading capacities were observed for the pure culturesisolated from it, suggesting that other members of this consortium were necessary for these hydrolyzing activities.Our results indicated that Paenibacillus sp. and Variovorax sp. as well as VG-4 consortium, might be a useful sourceof hydrolytic enzymes. Moreover, although Variovorax sp. had been previously identified in metagenomic studiesof cellulolytic communities, this is the first report on the isolation and characterization of this microorganism as acellulolytic genus.","palabras_clave":"cellulolytic bacteria|Variovorax |Paenibacillus|soil"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2064,"idioma_id":4,"titulo":"Diastolic function during hemorrhagic shock in rabbits","resumen":"Hemorrhage (H) is associated with a left ventricular (LV) dysfunction. However, the diastolic function has not been studied in detail. The main goal was to assess the diastolic function both during and 120 min after bleeding, in the absence and in the presence of L-NAME. Also, the changes in mRNA and protein expression of nitric oxide synthase (NOS) isoforms were determined. New Zealand rabbits were divided into three groups: Sham group, H group (hemorrhage 20% blood volume), and H L-NAME group (hemorrhage treated with L-NAME). We evaluated systolic and diastolic ventricular functions in vivo and in vitro (Langendorff technique). Hemodynamic parameters and LV function were measured before, during, and at 120 min after bleeding. We analyzed the isovolumic relaxation using t ½ in vivo (closed chest). After that, hearts were excised and perfused in vitro to measure myocardial stiffness. Samples were frozen to measure NOS mRNA and protein expression. The t½ increased during bleeding and returned to basal values 120 min after bleeding. L-NAME blunted this effect. Data from the H group revealed a shift to the left in the LV end diastolic pressure-volume curve at 120 min after bleeding, which was blocked by L-NAME. iNOS and nNOS protein expression and mRNA levels increased at 120 min after the hemorrhage. Acute hemorrhage induces early and transient isovolumic relaxation impairment and an increase in myocardial stiffness 120 min after bleeding. L-NAME blunted the LV dysfunction, suggesting that NO modulates ventricular function through iNOS and nNOS isoforms.","palabras_clave":"HEMORRAGIA|CONEJO|SHOCK HEMORRÁGICO|ÓXIDO NÍTRICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2065,"idioma_id":4,"titulo":"Breakup coupling effects on near-barrier inelastic scattering of the weakly bound 6Li projectile on a 144Sm target","resumen":"Nuclear Physics A 873, 17 (2012)  \/\/\/  Angular distributions for the inelastic scattering of the weakly bound 6Li nucleus from a 144Sm target (associated with the contributions of both the $2_1^+$ and $3_1^-$ 144Sm excited states together) were measured at bombarding energies close to the Coulomb barrier. The experimental data were compared with expected results based on continuum discretized coupled-channel (CDCC) calculations. The results confirm that it is essential to include continuum?continuum couplings to reproduce the experimental data. The analysis demonstrates that inelastic scattering data can be a critical tool in testing full CDCC calculations involving weakly bound nuclei.","palabras_clave":"I+144Sm(+6Li,+6Li), E = 23.035.1 MeV|measured scattered +6Li spectra using surface barrier detector array|deduced |s(|q) for different target excitations|Comparison with continuum discretized coupled-channel calculations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2067,"idioma_id":4,"titulo":"Discovery, validation and in silico functional characterization of EST-SSR markers in Eucalyptus globulus","resumen":"Abstract Eucalyptus globulus is the most commonly  planted hardwood species for pulpwood in temperate  regions. We aimed to develop and characterize functional  molecular markers for population genetic analyses and  molecular breeding in this model tree species. Public  expressed sequence tag (EST) databases were screened for  nonredundant sequences to predict putative gene functions  and to discover simple sequence repeats (EST-SSRs), which  were then validated in E. globulus and six other Eucalyptus  species. A total of 4,924 nonredundant sequences were  identified from 12,690 updated E. globulus ESTs. Approximately  19.3% (952) were unigenes and contained 1,140  EST-SSR markers, which were mainly trimeric (58.6%). A  set of 979 primers for putative SSR markers was designed  after bioinformatic analysis. The predicted functions of  these ESTs containing SSR were classified according to  their gene ontology (GO) categories (biological process,  molecular function, and cellular component). GO categories  were assigned to 226 ESTs (30.2%). Most ESTs containing  SSR (78.7%) had significant matches (E&#8804;10&#8722;5) with the  nonredundant protein database using BLASTX. From a set of  56 random primer pairs, 37 could be validated in eight E.  globulus genotypes and were also tested for crosstransferability  to other six Eucalyptus species (Eucalyptus  grandis, Eucalyptus saligna, Eucalyptus dunnii, Eucalyptus  viminalis, Eucalyptus camaldulensis, Eucalyptus tereticornis).  Seventeen polymorphic EST-SSR markers for E.  globulus were evaluated in 60 unrelated trees, being  representative of the species? natural distribution. As a result,  six highly informative markers were proposed for genetic  diversity analyses, fingerprinting, and comparative population  studies, between different species of E. globulus.","palabras_clave":"Eucalyptus globulus |EST-SSR|Functional diversity| Polymorphism"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2072,"idioma_id":4,"titulo":"A study of chlorophyll-like and phycobilin pigments in the C endosymbiont of the apple snail Pomacea canaliculata.","resumen":"Pigments present in the brown-greenish C morph of an intracellular endosymbiont of Pomacea canaliculata were investigated. Acetone extracts of the endosymbiotic corpuscles showed an absorption spectrum similar to that of chlorophylls. Three fractions obtained from silica gel column chromatography of the acetone extracts (CI, CII and CIII), were studied by positive ion fast atom bombardment-mass spectrometry (FAB\u2013MS) and hydrogen-nuclear magnetic resonance (H-NMR). Results indicated the presence of (1) a sterol in the yellow colored CI fraction; (2) a mixture of pheophorbides a and b in the major green fraction,CII; and (3) a modified pheophorbide a in the smaller green fraction, CIII. Aqueous extracts of the C endosymbiont did not show evidence of the occurrence of C-phycocyanin, allophycocyanin or phycoerithrin (light absorption, fluorescence emission, and electrophoresis of the protein moieties) while cyanobacterial cells (Nostoc sp.) showed evidence of C-phycocyanin and allophycocyanin. The possible phylogenetic and functional significance of the pigments present in the C endosymbiont is discussed.","palabras_clave":"symbiosis|Cyanobacteria|chloroplast|photosynthetic pigments"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2079,"idioma_id":4,"titulo":"Pulsed light treatment of cut apple: dose effect on color, structure and microbiological stability","resumen":"This study investigated the effect of pulsed light (PL) dose on color, microstructure, and microbiological stability of cut apples during 7-day refrigerated storage. Apples were irradiated at two different distances from the lamp (5 or 10 cm) during 2 to 100 s (2.4 to 221.1 J\/cm2). Cut-apple surface exposed to high PL fluencies turned darker (lower L* values) and less green (higher a* value) than the control, and this effect was more pronounced as PL dose and\/or storage time increased. On the contrary, the application of few flashes (2.4 J\/cm2) allowed maintaining the original color of apples slices along storage. Light microscopy images of treated samples showed degraded walls and broken plasmalemma and tonoplast, which may explain, at least partially , the increase in browning of irradiated apples at high doses. Inactivation patterns of inoculated microorganisms depended on PL dose and the type of microorganism. After 100 s PL treatment at 5 cm, no counts were observed for Saccharomyces cerevisiae KE162, while for Escherichia coli ATCC 11229 and Listeria innocua ATCC 33090, reduction levels were 2.25 and 1.7 logs, respectively . Native microflora population was in general higher in control samples than in 10 and 60 s PL irradiated apples along the whole storage. Although the application of high PL fluencies allowed obtaining greater microbial reductions, they also promoted browning of apple. Application of PL at a dose of 11.9 J\/cm2 could extend the shelf life of cut apple with minimal modification in color.","palabras_clave":"PULSED LIGHT |CUT APPLE |COLOR|MICROBIOLOGICAL STABILITY|STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2080,"idioma_id":4,"titulo":"Shape changes of Pt nanoparticles induced by deposition on mesoporous silica","resumen":"Polyvinylpyrollidone (PVP)-capped platinum nanoparticles (NPs) are found to change shape from spherical to flat when deposited on mesoporous silica substrates (SBA-15). Transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and extended X-ray absorption fine structure (EXAFS) analyses are used in these studies. The SAXS results indicate that, after deposition, the 2 nm NPs have an average gyration radius 22% larger than in solution, while the EXAFS measurements indicate a decrease in first neighbor co-ordination number from 9.3 to 7.4. The deformation of these small capped NPs is attributed to interactions with the surface of the SBA-15 support, as evidenced by X-ray absorption near-edge structure (XANES)","palabras_clave":"catalysis|mesoporus silica|nanoparticles|X-ray absorption spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2085,"idioma_id":4,"titulo":"IMPAIRMENTS ON AROMATASE EXPRESSION, REPRODUCTIVE BEHAVIOR AND SPERM QUALITY OF MALE FISH EXPOSED TO 17â-ESTRADIOL","resumen":"Growing evidence shows that environmental estrogen can reach levels that are high enough to exert adverse reproductive effects on wild fish populations. The authors report different parameters of male reproductive behavior, brain, and gonadal aromatase expression, as well as sperm quality in an internally fertilizing fish species (Jenynsia multidentata, Jenyns) exposed to environmentallyrelevant concentrations of 17b-estradiol (E2). Adult males were exposed to 0, 50, 100, and 250 ng\/L E2 over 28 d. The authors\u2019 findings demonstrate that E2 exposure resulted in a very clear increase in brain aromatase transcript abundance at all assayed concentrations compared with control; however, no effects on gonadal aromatase expression were observed. Behavioral measures revealed increased sexual activity at 50 ng\/L but not 100 or 250 ng\/L E2. In contrast to the molecular and behavioral responses, the condition factor, gonadosomatic index, and sperm quality were unaltered by E2 exposure. The results from the present work suggest that E2 affects some aspects of the reproductive biology of J. multidentata. These modifications in the reproductive biology caused by exposure to E2 could potentially lead to long-term effects at population levels that may not always be immediately evident. To the best of the authors\u2019knowledge, this is the first report on the combined effect of E2 on aromatase expression, sexual behavior, and sperm parameters in fish. ","palabras_clave":"17-beta estradiol|Jenynsia multidentata|Aromatasa expression|Sexual behavior|Sperm quality"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2089,"idioma_id":4,"titulo":"Monte Carlo study of binary mixtures adsorbed on square lattices","resumen":"The monolayer adsorption of interacting binary mixtures on 2D square lattices has been studied through grand canonical Monte Carlo simulation in the framework of the lattice-gas model. The process has been monitored through total and partial isotherms and differential heats of adsorption corresponding to both species of the mixture. Repulsive lateral interactions between the adsorbed particles have been considered, resulting in a rich variety of structural orderings in the adlayer. At the end of this work, the phase diagram characterizing the transitions occurring in the system has been determined. A nontrivial interdependence between the partial surface coverage of both species was observed and discussed.","palabras_clave":"SURFACE|SIMULATION|POLYATOMIC|ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2091,"idioma_id":4,"titulo":"Mechanisms of monomeric and dimeric glycogenin autoglucosylation","resumen":"Initiation of glucose polymerization by glycogenin autoglucosylation at the Tyr194 residue is required to prime de novo biosynthesis of glycogen. It has been proposed that the synthesis of the primer proceeds by intersubunit glucosylation of dimeric glycogenin, even though it has not been demonstrated that this mechanism is responsible for the described polymerization extent of 12 glucoses produced by the dimer. We previously reported the intramonomer glucosylation capability of glycogenin without determining the extent of autoglucopolymerization. Here we describe that the maximum specific autoglucosylation extent (MSAE) produced by non-glucosylated glycogenin monomer is 13.3 ± 1.9 glucoses, similar to the 12.5 ± 1.4 glucose units measured for the dimer. The mechanism and capacity of the dimer enzyme to carry out full glucopolymerization was also evaluated by construction of heterodimers able to exclusively glucosylate by intrasubunit or intersubunit reaction mechanisms. The MSAE of non-glucosylated glycogenin produced by dimer intrasubunit glucosylation was 16% of that produced by the monomer. However, partially glucosylated glycogenin was able to almost complete its autoglucosylation by the dimer intrasubunit mechanism. The MSAE produced by heterodimer intersubunit glucosylation was 60% of that produced by the wild-type dimer. It is concluded that both intrasubunit and intersubunit reaction mechanisms are necessary for dimer enzyme to acquire maximum autoglucosylation. The full glucopolymerization capacity of monomeric glycogenin indicates that the enzyme is able to synthesize the glycogen primer without the need for prior dimerization.","palabras_clave":"GLYCOGENIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2096,"idioma_id":4,"titulo":"Synthesis, Characterization, and Gamma Radiation Effects Over Well-Defined Poly(vinylsiloxanes) Copolymers","resumen":"Anionic ring-opening polymerization (AROP)was employed for the controlled synthesis of linear model block copolymers of 1,3,5,7-tetrametil-1,3,5,7-tetravinyl(cyclotetrasiloxane)(V4) and 1,3,5-dimethyl(cyclotrisiloxane)(D3) monomers by using sec-butyl lithium (sec-BuLiþ) as initiator, and high-vacuum anionic polymerization techniques.V4 copolymerization was promoted by employing D3 and sec-BuLiþ producing living silanolates that open the stable V4 ring. For this purpose, two strategies were applied: (a) sequential addition of monomers, and (b) onestep copolymerization at different reaction temperatures.According to the experimental results, higher levels of V4 incorporation ( 18.14 mol %) were obtained by mixingboth co-monomers and performing the reaction at high temperature (80C). This strategy allowed the control of the V4 incorporation into the copolymer structure, giving the opportunity of synthesizing model vinyl-siloxane polymers. The gamma radiation of these materials showed thatlower doses are needed to achieve the same gel content as in a model poly(dimethylsiloxane) (PDMS). In such a sense, these results constitute one of the first reports regarding the effect of gamma radiation on vinyl-containing silicon polymers,and may be of fundamental importance if a biomedical cross-linked rubber-type PDMS is needed at earlierdoses of sterilization.","palabras_clave":"ANIONIC POLYMERIZATION |COPOLYMERIZATION|VINYL-SILOXANE|GAMMA RADIATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2099,"idioma_id":4,"titulo":"(-)-5,6-Dehydrocamphor from the antifungal essential oil of Zuccagnia punctata","resumen":"The essential oils from aerial parts of nine populations of Zuccagnia punctata Cav. (Fabaceae)were obtained by hydrodistillation and analysed by GC-FID, GC-MS and 13C NMR. A total of 80constituents, mainly oxygenated monoterpenes, were identified representing from 79.0 to 95.2% of thetotal oils which showed different composition patterns. The unusual compound (-)-5,6-dehydrocamphor, the major constituent in six of the samples investigated with percentages rangingfrom 12.3% to 56.5%, was isolated for the first time from nature and its structure was completelydefined from NMR data. Microscope studies of leaves indicated that not only capitate glands but alsonon-glandular trichomes, not previously described in this species, were present on the leaf surfaces.The essential oil showed antifungal activity against the dermatophytes Microsporum gypseum,Tricophyton rubrum and T. mentagrophytes with MIC values between 15.6-125 ìg ml-1, being T.rubrum the most susceptible species.","palabras_clave":"ZUCCAGNIA PUNCTATA|FABACEAE|ESSENTIAL OIL;|(-)-5,6-DEHYDROCAMPHOR|ANTIFUNGAL ACTIVITY|DERMATOPHYTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2104,"idioma_id":4,"titulo":"Potato snakin-1 gene silencing affects cell division, primary metabolism and cell wall composition","resumen":"Snakin-1 (SN1) is an antimicrobial cysteine-rich peptide isolated from potato (Solanum tuberosum) that was classified as a member of the Snakin\/Gibberellic Acid Stimulated in Arabidopsis protein family. In this work, a transgenic approach was used to study the role of SN1 in planta. Even when overexpressing SN1, potato lines did not show remarkable morphological differences from the wild type; SN1 silencing resulted in reduced height, which was accompanied by an overall reduction in leaf size and severe alterations of leaf shape. Analysis of the adaxial epidermis of mature leaves revealed that silenced lines had 70% to 90% increases in mean cell size with respect to wild-type leaves. Consequently, the number of epidermal cells was significantly reduced in these lines. Confocal microscopy analysis after agroinfiltration of Nicotiana benthamiana leaves showed that SN1-green fluorescent protein fusion protein was localized in plasma membrane, and bimolecular fluorescence complementation assays revealed that SN1 self-interacted in vivo. We further focused our study on leaf metabolism by applying a combination of gas chromatography coupled to mass spectrometry, Fourier transform infrared spectroscopy, and spectrophotometric techniques. These targeted analyses allowed a detailed examination of the changes occurring in 46 intermediate compounds from primary metabolic pathways and in seven cell wall constituents. We demonstrated that SN1 silencing affects cell division, leaf primary metabolism, and cell wall composition in potato plants, suggesting that SN1 has additional roles in growth and development beyond its previously assigned role in plant defense.","palabras_clave":"potato|gibberellin|snakin|silencing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2109,"idioma_id":4,"titulo":"Physico-chemical and toxicological assessment of liquid wastes from olive processing-related industries","resumen":"BACKGROUND: In the last few years, agricultural uses of waste waters from olive processing-related industries have been gaining interestmainlywith a view to composting or bio-fertilizers. The present work examines physico-chemical, toxicological and geno-toxicological properties of three liquidwastes, namely olivemill wastewater (OMWW), olivewet husk and olive brine. The effect of OMWWspreading on soilmicrobial activity and biomass was also evaluated. RESULTS: Data from Artemia salina and Lactuca sativa toxicity tests indicated high levels of lethality, and inhibitory effects on seed germination and seedling growth of all olive wastes. The genotoxicity assays using Allium cepa tests showed contrasting results. At high concentrations, olivewastes caused inhibition or suppression of mitosis. However, they did not produce induced anaphase aberrations. Data on reversion of Salmonella thyphimurium strains using the Ames test indicated that the olivewastes did not present mutagenic activity. Results from the field experiment showed that OMWW at a 500m3 ha&#8722;1 had the highest values of both soil microbial activity and biomass after 3months of the amendment application. CONCLUSION: This work adds new data for environmental risk assessment of olive industrial wastes. Direct use of olive wastes for agricultural purposes should be limited owing to their possible chemotoxic, phytotoxic and antimicrobial effects.","palabras_clave":"olive wastes|physico-chemical characterization|toxicological evaluation|antimicrobial effects|environmental risk assessment"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2110,"idioma_id":4,"titulo":"Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle","resumen":"Abstract  Background  In bovines, there are significant differences within and among beef breeds in the time when  bulls reach puberty. Although the timing of puberty is likely to be a multigenic trait, previous  studies indicate that there may also be single genes that exert major effects on the timing of  puberty within the general population. Despite its economic importance, there are not many  SNPs or genetic markers associated with the age of puberty in male cattle. In the present  work, we selected three candidate genes, GNRHR, LHR and IGF1, and associated their  polymorphisms with the age of puberty in Angus male cattle.  Results  After weaning, 276 Angus males were measured every month for weight (W), scrotal  circumference (SC), sperm concentration (C) and percentage of motility (M). A total of 4  SNPs, two within GNRHR, one in LHR and one in IGF1 were genotyped using the  pyrosequencing technique. IGF1-SnaBI SNP was significant associated (P < 0.01) with age at  SC 28 cm, but it were not associated with age at M 10% and C 50 million. Genotype CC  exhibited an average age at SC 28 cm of 7 and 11 days higher than CT (p = 0.037) and TT  (p = 0.012), respectively. This SNP explained 1.5 % of the genetic variance of age of puberty  at SC28. LHR-I499L, GNRHR-SNP5 and GNRHR-SNP6 were not associated with any of the  measurements. However, GNRHR haplotypes showed a suggestive association with age at SC  28 cm.  Conclusions  The findings presented here could support the hypothesis that IGF1 is a regulator of the  arrival to puberty in male calves and is involved in the events that precede and initiate  puberty in bull calves. Given that most studies in cattle, as well as in other mammals, were  done in female, the present results are the first evidence of markers associated with age at  puberty in male cattle.","palabras_clave":"Gonadotropin releasing hormone receptor|Luteinizing hormone receptor|Insulin-like growth factor 1|Bovine|Polymorphism|Male Puberty"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2119,"idioma_id":4,"titulo":"Searching the 'biologically relevant' conformation of dopamine: A computational approach","resumen":"We report here an exhaustive and complete conformational study on the conformational potential energy hypersurface (PEHS) of dopamine (DA) interacting with the dopamine D2 receptor (D2-DR). A reduced 3D model for the binding pocket of the human D2-DR was constructed on the basis of the theoretical model structure of bacteriorhodopsin. In our reduced model system, only 13 amino acids were included to perform the quantum mechanics calculations. To obtain the different complexes of DA\/D2-DR, we combined semiempirical (PM6), DFT (B3LYP\/6-31G(d)), and QTAIM calculations. The molecular flexibility of DA interacting with the D2-DR was evaluated from potential energy surfaces and potential energy curves. A comparative study between the molecular flexibility of DA in the gas phase and at D2-DR was carried out. In addition, several molecular dynamics simulations were carried out to evaluate the molecular flexibility of the different complexes obtained. Our results allow us to postulate the complexes of type A as the 'biologically relevant conformations' of DA. In addition, the theoretical calculations reported here suggested that a mechanistic stepwise process takes place for DA in which the protonated nitrogen group (in any conformation) acts as the anchoring portion, and this process is followed by a rapid rearrangement of the conformation allowing the interaction of the catecholic OH groups. © 2011 American Chemical Society.","palabras_clave":"Computational approach; |Conformational study| Molecular flexibility;|Molecular dynamics simulations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2120,"idioma_id":4,"titulo":"Recombinant protein purification using complementary peptides as affinity tags","resumen":"Affinity tags have become highly popular tools for purifying recombinant proteins from crude extracts by affinity chromatography. Besides, short peptides are excellent ligands for affinity chromatography, as they are not likely to cause an immune response in case of leakage into the product, they are more stable than antibodies to elution and cleaning conditions and they usually have very acceptable selectivity. Hydropathically complementary peptides designed de novo show enough selectivity to be used successfully as peptide ligands for protein purification from crude extracts. Recognition specificity and selectivity in the interaction between the complementary peptide pair His-Leu-Leu-Phe-Pro-Ile-Ile-Ile-Ala-Ala-Ser-Leu and Lys-Asn-Tyr-Pro-Lys-Lys-Lys-Met-Glu-Lys-Arg-Phe have been demonstrated by other authors. In this work, we designed a recombinant protein purification method using a peptide affinity tag that binds to a peptide-binding partner immobilized on a chromatographic matrix. The enhanced green fluorescent protein expressed (EGFP) in E. coli was used as the model. The peptide Gly-Gly-Gly-His-Leu-Leu-Phe-Pro-Ile-Ile-Ile-Ala-Ala-Ser-Leu was synthesised by solid phase using the Fmoc chemistry and immobilized in NHS-Sepharose (PC-Sepharose). Gly residues were added as a spacer arm at the N terminus. The EGFP was expressed either with the fusion tag Lys-Asn-Tyr-Pro-Lys-Lys-Lys-Met-Glu-Lys-Arg-Phe on the C terminus (EGFP-CPTag) or without any fusion tag. After cell disruption, the extract was directly applied to the PC-Sepharose column equilibrated with 20 mM sodium phosphate buffer, pH 7.0. The adsorbed EGFP-CPTag was then eluted with 1 M Tris. The yield was 98% and the purification factor 4.6. On the other hand, EGFP without tag pass through without interacting with the PC-Sepharose column. The method designed can be applied for the purification of other recombinant proteins.","palabras_clave":"AFFINITY TAGS|PURIFICATION|EGFP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2129,"idioma_id":4,"titulo":"Monitoring of Phenolic Compounds for the Quality Control of Melissa officinalis Products by Capillary Electrophoresis","resumen":"Monitoring of phenolic compounds for the quality control of Melissa officinalis products by capillary electrophoresis.    Acosta G, Arce S, Martínez LD, Llabot J, Gomez MR.  Source  Química Analítica, Universidad Nacional de San Luis, Facultad de Química, Bioquímica y Farmacia, UNSL Chacabuco y Pedernera, San Luis, Argentina.      Abstract  INTRODUCTION:  Official assays for the quality control of Melissa officinalis L. (Lamiaceae) leaves establish the quantification of total hydroxycinnamic derivatives expressed as rosmarinic acid.  OBJECTIVE:  The goal of this work was to develop a simple, fast and reliable method for monitoring the phenolic composition in herbs from the Lamiaceae family and for rapidly detecting M. officinalis adulteration or substitution in commercial medicinal samples in Argentina.  METHODOLOGY:  A capillary zone electrophoresis (CZE) method was performed under the following conditions: the background electrolyte (BGE) consisted of 20&#8201;m m sodium tetraborate buffer, pH&#8201;9.2; the applied voltage was 25&#8201;kV; the capillary and sample temperatures were kept at 25&#8201;°C; the hydrodynamic mode was selected for the sample injection (3.45&#8201;kPa during 5&#8201;s).  RESULTS:  A CZE method that achieved the separation and simultaneous determination of eight related phenolic compounds in less than 11&#8201;min was optimised for application to control quality analysis of M. officinalis-based products. The method was validated according to the US Federal Drug Agency requirements and offers advantages in terms of analysis time, cost and operation.  CONCLUSIONS:  The proposed methodology can be applied to the standardisation and quality control of plant material and phytopharmaceutical products derived from the Lamiaceae family, as indicated by the results obtained in the analysis of commercial medicinal products in Argentina.  Copyright © 2011 John Wiley &amp; Sons, Ltd.","palabras_clave":"MELISSA OFFICINALIS |LAMIACEAE|CAPILLARY ELECTROPHORESIS|PHENOLIC  COMPOUNDS| FINGERPRINTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2133,"idioma_id":4,"titulo":"An exceptional storm accumulation of nautilids, Lower Cretaceous, Neuquén Basin, Argentina","resumen":"Cichowolski, M., Pazos, P.J., Tunik, M.A. &amp; Aguirre-Urreta, M.B. 2011: An exceptional storm accumulation of nautilids in the Lower Cretaceous of the Neuquén Basin, Argentina. Lethaia, DOI: 10.1111\/j.1502-3931.2011.00271.x An exceptional accumulation of nautilid shells of the species Cymatoceras perstriatum (Steuer) is reported and described in the Lower Cretaceous Agrio Formation of the Neuquén Basin (west-central Argentina). The bed represents a storm deposit in a shallow-water environment within the mid-ramp. The evidences of a storm-related origin of the bed come from the petrographic analysis and taphonomic features of the shells, specially the sedimentary infill pattern. The shells are dispersed in patches within the stratum, without any orientation relative to the bedding plane. It is proposed that the shells were floating after the death of the animals, although most of them have an almost complete living chamber. The presence of some heavily encrusted shells suggests that there is a mixing of specimens with different drift times. A variety of factors related to the origin of such high number of nautilid shells are discussed, including a transgressive stand system tract, the possible existence of a gregarious behaviour, changes in salinity and wind directions. &#9633;Lower Cretaceous, Nautilids, Neuquén Basin, shell accumulation, storm deposit. © 2011 The Authors, Lethaia © 2011 The Lethaia Foundation.","palabras_clave":"Cretaceous|Nautilids|Neuquen Basin|Storm Deposits"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2138,"idioma_id":4,"titulo":"Dietary habits and prostate cancer prevention: a review of Observational studies by focusing on South America","resumen":"There exist several works considering the association between diet and prostate cancer (PC) risk, but the issue is largely unsettled. This article systematically reviews the epidemiological studies on diet and risk of PC focusing on those carried out in countries of South America. There is some suggestion that dairy products, red meat, processed meat, &#945;-linoleic fatty acids, as well as dietary patterns characterized by higher intakes of red and processed meat, eggs and grains, may play some role in the development of prostate cancer. There is no clear association with the intake of vegetables and fruits, lycopene, fats, and different types of fatty acids.  The evidence on diet and prostate cancer is therefore inconclusive in general and specifically in South America. Particular attention must be paid to the study of cancer risk in some countries of South America because of the singularly risky dietary pattern consumed by its population.","palabras_clave":"PROSTATE CANCER|DIET|EPIDEMIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2140,"idioma_id":4,"titulo":"The effect of the diterpene 5-epi-icetexone on the cell cycle of Trypanosoma cruzi","resumen":"Numerous natural compounds have been used against Trypanosoma cruzi, the causative agent of Chagas´ disease. Here, we studied the effect of the diterpene 5-epi-icetexone on growth and morphology of parasites synchronized with hydroxyurea, at different periods of time after removal of the nucleotide. We observed that the diterpene does not affect the growth of the parasites when added within 10 h after removal of hydroxyurea, but the compound was effective on growth when added to the cultures after 12 h. Thymidine incorporation was somewhat inhibited when the diterpene was added at 12 h after removal of hydroxyurea, possibly on the transition S\/G2. Using transmission electron microscopy we observed that the diterpene induced a delay in the progression of cell division. We conclude that the compound, at cytostatic dose, affects the cell cycle of T. cruzi, possibly in the transition S\/G2 phase and cell division. Further studies will focus to identify the molecular targets for the action of 5-epi-icetexone.","palabras_clave":"TRYPANOSOMA|COMPOUNDS|DITERPENE|CYCLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2145,"idioma_id":4,"titulo":"Dietary treatments enriched in olive and safflower oils regulate seric and placental matrix metalloproteinases in maternal diabetes","resumen":"Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in placental development and function, although related to the pro-inflammatory environment when produced in excess. Previous studies have identified MMP-2 and MMP-9 overactivities in the placenta from diabetic rats. In this study, we aimed to determine whether diets supplemented with olive and safflower oil, enriched in natural PPAR ligands, are able to regulate MMP-2 and MMP-9 activities in the placenta and serum from diabetic rats.   Diabetes was induced in rat neonates by streptozotocin administration (90 mg\/kg s.c.). Control and diabetic rats were fed with 6% olive oil- or 6% safflower oil- supplemented diets from days 0.5 to 13.5 of gestation. On day 13.5 of gestation, placentas and sera were isolated for further determination of matrix metalloproteinases (MMPs) 2 and 9 activities by zymography. Placental MMP-2 and MMP-9 protein concentration and immunolocalization were also determined. Results Sera from diabetic pregnant animals showed MMP-2 and MMP-9 overactivities when compared to controls. Serum MMP-9 activity was significantly decreased when the diabetic animals received the olive and safflower oil dietary treatments. Placentas from diabetic rats showed increased MMP-2 and MMP-9 activities and protein concentrations, and both were decreased when diabetic rats received the olive and safflower dietary treatments.   Conclusions This study demonstrates that both olive and safflower oil- supplemented diets were able to prevent MMPs overactivities in the placenta from diabetic rats, and that these beneficial effects are reflected in rat sera.","palabras_clave":"Placenta|Diabetes|Metaloproteasas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2146,"idioma_id":4,"titulo":"The Killing--Yano equation on Lie groups","resumen":"In this paper we study 2-forms which are solutions of the Killing-Yano equation  on Lie groups endowed with a left invariant metric having various curvature  properties. We prove a general result for 2-step nilpotent Lie groups and as a  corollary we obtain a nondegenerate solution of the Killing-Yano equation on  the Iwasawa manifold with its half-flat metric.","palabras_clave":"KILLING-YANO TENSOR|2-STEP NILPOTENT LIE GROUP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2149,"idioma_id":4,"titulo":"Administration of Lactobacillus fermentum CRL1446 increases intestinal feruloyl esterase activity in mice","resumen":"Aims: To evaluate the effect of oral administration of Lactobacillus fermentum CRL1446 on the intestinal feruloyl esterase (FE) activity and oxidative status of mice. Methods and Results: Adult Swiss albino mice received Lact. fermentum CRL1446 at the doses 10 7 and 10 9 cells per day per mouse for 2, 5, 7 and 10days. Intestinal FE activity, intestinal microbiota counts, plasmatic thiobarbituric acid-reactive substances (TBARS) percentage and glutathione reductase (GR) activity were determined. Mice that received Lact. fermentum CRL1446 at the dose 10 7 cells per day for 7days showed a twofold increase in total intestinal FE activity, compared to the nontreated group. In large intestine content, FE activity increased up to 6·4 times. No major quantitative changes in colonic microbiota were observed in treated animals. Administration of this strain produced an approx. 30-40% decrease in the basal levels of plasmatic TBARS and an approx. twofold increase in GR activity from day 5 of feeding with both doses. Conclusions: Oral administration of Lact. fermentum CRL1446 to mice increases total intestinal FE activity, decreases the basal percentage of plasmatic lipoperoxides and increases GR activity. Significance and Impact of the Study: Lactobacillus fermentum CRL1446 could be orally administered as a dietary supplement or functional food for increasing the intestinal FE activity to enhance the bioavailability of ferulic acid, thus improving oxidative status. © 2011 The Authors. Letters in Applied Microbiology © 2011 The Society for Applied Microbiology.","palabras_clave":"LACTOBACILLUS FERMENTUM|ORAL ADMINISTRATION|OXIDATIVE STATUS|FERULOYL ESTERASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2153,"idioma_id":4,"titulo":"Biodegradable starch nanocomposites with low water vapor permeability and high storage modulus","resumen":"Nanocomposite materials based on a starch matrix reinforced with very small amounts of multi-walled carbon nanotubes (MWCNTs) (from 0.005 wt% to 0.055 wt%) were developed. The material?s dynamicmechanical and water vapor permeability properties were investigated. An increasing trend of storage modulus (E) and a decreasing trend of water vapor permeability (WVP) with filler content were observed at room temperature. For the composite with 0.055 wt% of filler, E value was about 100% higher and WVP value was almost 43% lower than the corresponding matrix values. MWCNTs were wrapped in an aqueous solution of a starch?iodine complex before their incorporation into the matrix, obtaining exceptionally well-dispersed nanotubes and optimizing interfacial adhesion. This excellent filler dispersion leads to the development of an important contact surface area with the matrix material, producing remarkable changes in the starch-rich phase glass transition temperature even in composites with very low filler contents. This transition is shifted towards higher temperatures with increasing content of nanotubes.So at room temperature, some composites are in the rubber zone while others, in the transition zone.Therefore, this change in the material glass transition temperature can be taken as responsible for the important improvements obtained in the composites WVP and E values for carbon nanotubes content","palabras_clave":"Starch-Carbon nanotubes nanocomposites|Starch-iodine complex|Dynamic mechanical properties|Water vapor permeability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2166,"idioma_id":4,"titulo":"Underpotential Deposition on Free Nanoparticles: its Meaning and Measurement","resumen":"The meaning of underpotential shift is discussed for free nanoparticles, where a redox couple is used to set potential control on them. Atomistic Monte Carlo simulations are performed to study their decoration in the submonolayer regime. The resulting configurations are used to simulate their plasmon spectra by means of a state-of-the art quantum mechanical atomistic model.","palabras_clave":"nanoparticulas|deposición a subpotenciales|plasmones|oro"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2175,"idioma_id":5,"titulo":"COMPARACIÓN DE CARACTERES CORPORALES Y DEL VENENO DE BOTHROPS ALTERNATUS ENTRE POBLACIONES DE LAS PROVINCIAS DE BUENOS AIRES Y ENTRE RÍOS, ARGENTINA","resumen":"Comparamos caracteres corporales y producción de veneno de ejemplares de Bothropsalternatus de una población aislada geográficamente (Olavarría, región de Tandilia, BuenosAires) con otra en su área de distribución continua de Concordia (Entre Ríos). Estudiamos ellargo corporal, peso, separación entre dientes inoculadores, cantidad de veneno y de proteínasen el veneno por ejemplar. No se hallaron diferencias en los caracteres estudiados entreambas poblaciones (p &gt; 0.05). Las hembras fueron mayores que los machos en ambas muestras,entre un 12-18% (p &lt; 0.05) respecto al largo corporal, y entre 38-57% respecto al peso.No se hallaron diferencias significativas entre los ejemplares de ambas localidades en la cantidadde veneno obtenido respecto a su materia seca (p &gt;0.5; Olavarría: 142 ± 65 mg\/animal,Concordia: 160 ± 80 mg\/animal), aún ajustando la cantidad de veneno producida respecto altamaño, mediante el cociente veneno\/largo corporal (p &gt;0.6). Tampoco hubo diferencias enel contenido proteico, siendo para ambas muestras de 0.697 ± 0.096 mg de proteínas\/mg deveneno seco. Nuestros datos sugieren que los ejemplares de la población aislada de Tandiliano presentan variaciones en el tamaño corporal o en la cantidad de veneno producida, respectoa los ejemplares de Concordia.","palabras_clave":"Serpientes; |Veneno; | Caracteres morfológicos;|Variación intraespecífica; |Dimorfismo sexual."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2177,"idioma_id":4,"titulo":"Electrocardiographic changes in normal and abnormal canine pregnancy","resumen":"The aim of this study was to describe the canine electrocardiographic changes in the course of normal and abnormal Twenty-three Brucellosis-negative pregnant bitches were retrospectively classified as (n = 12) or (n = 11). A control group of non-pregnant dioestrous bitches (n = 10) was also included. pregnant females delivered healthy puppies at term while animals interrupted their normal gestation while it decreased -1.8% in dioestrous bitches, although it did not change in the abnormal group (p abnormal pregnant group but not in the others, percentage QRSa change fell to -34% on day 60 (p normal gestations and dioestrous animals, respectively (p normal pregnant and dioestrous groups, respectively, while it remained unchanged in abnormal gestations (p normal canine pregnancy, some electrocardiographic parameters begin changing from day 40 onwards, and that pathological gestations differ from normality from day 30. The use of electrocardiography in canine obstetrics might contribute to identify abnormal outcomes before they become clinically evident","palabras_clave":"ELECTROCARDIOGRAFIC CHANGES|ABNORMAL|PREGNANCY|CANINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2192,"idioma_id":4,"titulo":"Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP - Protein kinase A pathway.","resumen":"Melanocortin 4 receptors (MC4R) are mainly expressed in the brain. We previously showed that the anti-inflammatory action of alpha-melanocyte-stimulating hormone (alpha-MSH) in rat hypothalamus and in cultured astrocytes involved MC4R activation. However, MC4R mechanisms of action remain undetermined. Since brain-derived neurotrophic factor (BDNF) may be mediating MC4R hypothalamic anorexigenic actions, we determined melanocortin effects on BDNF expression in rat cultured astrocytes and certain mechanisms  involved in MC4R signaling. alpha-MSH and its analogue NDP-MSH, induced production of cAMP in astrocytes. This effect was completely blocked by the MC4R antagonist, HS024. We found that NDP-MSH increased BDNF mRNA and protein levels in astrocytes. The effect of NDP-MSH on BDNF expression was abolished by the adenylate cyclase inhibitor SQ22536, and decreased by the PKA inhibitor Rp-cAMP. Since melanocortins are immunomodulators, we investigated their actions with bacterial lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulus. Although both alpha-MSH and LPS + IFN-gamma increased cAMP responding element binding protein (CREB) activation, LPS + IFN-gamma did not modify BDNF expression. On the other hand, alpha-MSH did not modify basal or LPS + IFN-gamma-induced nuclear factor-kB activation. Our results show for the first time that MC4R activation in astrocytes induces BDNF expression through cAMP-PKA-CREB pathway without involving NF-kB.","palabras_clave":"MC4R|BDNF|astrocytes|signaling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2193,"idioma_id":5,"titulo":"Relación entre parámetros  ultrasonográficos y edad gestacional en la gata doméstica","resumen":"Existen diferentes metodos para el diagnostico de la gestacion en felinos, sin embargo el examen ultrasonografico permite confirmar la preñez en forma temprana y brinda informacion sobre el desarrollo embrionario-fetal. El objetivo del trabajo fue relacionar diferentes parametros ultrasonograficos con el dia de gestacion. Se utilizaron gatas(n=10) mestizas de entre 24 y 36 meses de edad. El diagnostico de gestacion se realizo por ecografia 20 dias posteriores al dia del servicio. Se realizo un seguimiento ultrasonografico(Ecografo Mindray, DP-6600 vet, sonda lineal multifrecuencia[5-7,5-10 MHz]) diario desde el dia 21 postservicio hasta el parto. Se realizaron los siguientes registros ultrasonograficos: 1) Volumen del saco gestacional; 2) Diametro medio del saco gestacional; 3)Longitud craneo-caudal; 4) Diametro biparietal; 5) Diametro transverso abdominal del feto. Se realizo una correlacion entre los parametros evaluados con los dias de gestacion utilizando un analisis de regresion lineal. Todas las gatas presentaron una gestacion normal. Pudo visualizarse una correlacion entre los parametros estudiados con los dias de gestacion, dicha correlacion fue significativa (P<0.01) y con un alto coeficiente de regresion (P<0.01). Estos hallazgos podrian utilizarse en la estimacion de la edad gestacional y calculo de la fecha probable de parto en la gata.","palabras_clave":"Gatas|Ultrasonografia|Gestacion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2195,"idioma_id":5,"titulo":"El Herald y la doble transición política y comunicacional entre 1982-1983","resumen":"La intervención de los medios de comunicación como actores políticos ha tenido incidencia en la vida institucional del país desde sus orígenes. En momentos en los que se produce un importante debate respecto del rol del periodismo en el sistema democrático, como docentes e investigadores de la historia del periodismo, consideramos que la revisión de la actuación de medios y comunicadores durante la última dictadura cívico militar, resulta valiosa como aporte constitutivo a esta discusión. Con ese cometido, examinamos la columna editorial del Herald durante la transición democrática (14\/6\/82-30\/10\/83), teniendo en cuenta que este matutino, así como apoyó el golpe en marzo de 1976, también se convirtió en un consecuente impugnador de las políticas violatorias de libertades ciudadanas, los derechos humanos y las restricciones al periodismo ejecutados por la dictadura cívico-militar. Una vez finalizada la guerra de Malvinas, continuó enfatizando sobre estos reclamos pero relacionándolos con la institucionalización del país que se produjo con los comicios generales el 30 de octubre de 1983.","palabras_clave":"DIARIOS |DICTADURA |LIBERTAD DE EXPRESIÓN|TRANSICION DEMOCRATICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2199,"idioma_id":4,"titulo":"?Effect of the addition of conventional additives and whey proteins concentrates on technological parameters, physicochemical properties; microstructure and sensory attributes of sous vide cooked beef muscles?","resumen":"Beef muscles submitted to four enhancement treatments (1.88% whey protein concentrate (WPC) + 1.25% sodium chloride (NaCl); 1.88% modified whey protein concentrate (MWPC) + 1.25%NaCl; 0.25% sodium tripolyphosphate (STPP) + 1.25%NaCl; 1.25%NaCl) and a control treatment (non-injected muscles) were sous vide cooked. Muscles with STPP+NaCl presented a significantly higher total yield (106.5%) in comparison to those with WPC\/MWPC+NaCl (94.7% and 92.9%, respectively), NaCl alone (84.8%) or controls (72.1%). Muscles with STPP+NaCl presented significantly lower shear force values than control ones; also, WPC\/MWPC+NaCl added muscles presented similar values than those from the other treatments. After cooking, muscles with STPP+NaCl or WPC\/MWPC+NaCl depicted compacted and uniform microstructures. Muscles with STPP+NaCl showed a pink colour, meanwhile muscles submitted to the other treatments presented colours between pinkish-grey and grey-brown. STPP+NaCl added samples presented the highest values of global tenderness and juiciness. The addition of STPP+NaCl had a better performance than WPC\/MWPC+NaCl. However, the addition of WPC\/MWPC+NaCl to muscles improved total yield in comparison to NaCl added or controls ones","palabras_clave":"Sous vide system|Whey protein concentrate|Yield|Sodium chloride"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2204,"idioma_id":4,"titulo":"N, N´-dicyclohexylsulfamide and N,N´diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine Binding site of the GABAA receptor and anxiolytic activity in mice","resumen":"A set of sulfamides designed, synthesized and evaluated against maximal   electroshock seizure (MES) and pentilenetetrazol (PTZ) tests with   promising results, were tested for their affinity for the benzodiazepine   binding site of the GABA(A) receptor. The most active compounds,   N,N´-dicyclohexylsulfamide (7) and N,N´-diphenethylsulfamide (10),   competitively inhibited the binding of [(3)H]-flunitrazepam to the   benzodiazepine binding site with K(i)±SEM values of 27.7±4.5&#956;M (n=3) and   6.0±1.2&#956;M (n=3), respectively. The behavioral actions of these   sulfamides, i.p. administered in mice, were examined in the plus-maze,   hole-board and locomotor activity assays. Compound 7 exhibited   anxiolytic-like effects in mice evidenced by a significant increase of   the parameters measured in the hole-board test (at 1 and 3mg\/kg) and the   plus-maze assay (at 1 and 3mg\/kg). Compound 10 evidenced anxiolytic   activity in the plus-maze and the hole-board tests at 1mg\/kg. Locomotor   activity of mice was not modified by compound 7 or 10 at the doses   tested. Flumazenil, a non selective benzodiazepine binding site   antagonist, was able to completely reverse the anxiolytic-like effects   of these sulfamides, proving that the GABA(A) receptor is implicated in   this action. Anxiety represents a major problem for people with   epilepsy. The use of anxiolytic and anticonvulsant sulfamides would be   beneficial to individuals who suffer from both disorders.","palabras_clave":"Sulfamides|GABA-A receptor|Benzodiazepine binding site|anticonvulsant|anxiolytic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2205,"idioma_id":4,"titulo":"Phylogenetic affinities of the late Miocene Echimyidae Pampamys and the age of Thrichomys (Rodentia, Hystricognathi).","resumen":"Phylogenetic affinities of the late Miocene echimyid {Pampamys emmonsae Verzi, Vucetich, and Montalvo, 1995 (Huayquerian South American Land Mammal Age, central Argentina), were analyzed. In the mostparsimonious tree obtained, subfamilies of Echimyidae were nonmonophyletic (except for Dactylomyinae). Two major clades were recovered. One of them included the living fossorial Eumysopinae and the extinct {Theridomysops. The other clade grouped the terrestrial eumysopines Thrichomys (punare´) and Proechimys? Trinomys (spiny rats), and the arboreal eumysopines Mesomys (spiny tree-rats) + Echimyinae?Dactylomyinae. Pampamys was the sister genus of Thrichomys, suggesting the Huayquerian South American Land Mammal Age (.6.0 million years ago [mya] by biochronology) as a minimum age for the origin of the living genus. Bothmajor echimyid clades recognized here are represented by simplified-molared species in the Huayquerian South American Land Mammal Age. This would be related to the expansion of open environments during the late Miocene, and the geographical bias of the fossiliferous Huayquerian deposits exposed mostly in southern South America.","palabras_clave":"caviomorfos|Echimyidae|Mioceno tardío|América del Sur"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2208,"idioma_id":4,"titulo":"Effects of the induced birefringence in photorefractive crystals on speckle optical vortices","resumen":"In this work, we show that it is possible to change the properties of an optical vortex formed in a speckle pattern by the control of an external electric field applied to a sillenite-type photorefractive material in a non-holographic configuration. To show it, a scheme that allows the recovering of both, the polarization state and the phase distribution of an optical field was implemented. Changes in the polarization state of the light in the neighborhood of the vortex were observed with the application of an external electric field. Likewise, changes in the phase structure around the vortex and displacements of the vortices themselves were measured. These displacements have a fairly linear dependence on the applied field to the photorefractive crystal. Experimental results are qualitatively explained with the theoretical treatment of non-holographic recording in photorefractive crystals. ","palabras_clave":"OPTICAL VORTICES|SPECKLE|PHOTOREFRACTIVE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2210,"idioma_id":4,"titulo":"In vivo evidence of cross-reactivity between cow's milk and soybean proteins in a mouse model of food allergy","resumen":"      Abstract      BACKGROUND:       Cow´s milk allergy (CMA) is  an important problem worldwide and the development of an in vivo system to study  new immunotherapeutic strategies is of interest. Intolerance to soybean formula  has been described in CMA patients, but it is not fully understood. In this  work, we used a food allergy model in BALB\/c mice to study the cross-reactivity  between cow´s milk protein (CMP) and soy proteins (SP).      METHODS:       Mice were orally sensitized  with cholera toxin and CMP, and then challenged with CMP or SP to induce  allergy. Elicited symptoms, plasma histamine, humoral and cellular immune  response were analyzed. Th1- and Th2-associated cytokines and transcription  factors were assessed at mucosal sites and in splenocytes. Cutaneous  tests were also performed.      RESULTS:       We found that the immediate  symptoms elicited in CMP-sensitized mice orally challenged with SP were consistent  with a plasma histamine increase. The serum levels of CMP-specific IgE and IgG1  antibodies were increased. These antibodies also recognized soy proteins.  Splenocytes and mesenteric lymph node cells incubated with CMP or SP secreted  IL-5 and IL-13. mRNA expression of Th2-associated genes (IL-5, IL-13, and  GATA-3) was upregulated in mucosal samples. In addition, sensitized animals  exhibited positive cutaneous tests after the injection of CMP or SP.      CONCLUSIONS:       We demonstrate that  CMP-sensitized mice, without previous exposure to soy proteins, elicited  hypersensitivity signs immediately after the oral administration of SP,  suggesting that the immunochemical cross-reactivity might be clinically  relevant. This model may provide an approach to further characterize  cross-allergenicity phenomena and develop new immunotherapeutic treatments for  allergic patients.      .      &nbsp;  ","palabras_clave":"Food allergy |Cows milk|Mouse model|Cross-reactivity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2212,"idioma_id":5,"titulo":"Las prácticas de formación: el relato de lo  metodológico y  los avances interpretativos","resumen":"Lo que aquí se desarrolla tiene la intencionalidad de dar cuenta del proceso metodológico y de los sucesivos avances interpretativos, respecto de la investigación ?Obstáculos que afectan la relación teoría-práctica en las prácticas de formación: el caso particular de practicantes de la carrera de Ciencias de la Educación de la UNNE?; desarrollada entre los años 1999-2001.Se propuso ?escuchar? las voces de los practicantes; decisión montada sobre la comprensión de que en esta  actividad las investigadoras participarían en un proceso social de construcción de realidad o camino de comprensión de otros: los practicantes. Es decir, un proceso de recreación de cultura que cualificaba a la investigación como un escenario o ?foro para negociar y renegociar los significados? (Bruner, Jerome; 2004) en el que: (a) se privilegian las expresiones verbales; (b) se reúne lo dicho y lo actuado; (c) se convierte también en un dispositivo de formación para los mismos investigadores","palabras_clave":"obstaculos|prácticas de formación|dispositivos de formación|narración y dialogo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2221,"idioma_id":4,"titulo":"Probing protein surface with a solvent mimetic carbene coupled to detection by mass spectrometry","resumen":"Much knowledge into protein folding, ligand binding, and complex formation can be derived fromthe examination of the nature and size of the accessible surface area (SASA) of the polypeptidechain, a key parameter in protein science not directly measurable in an experimental fashion. Tothis end, an ideal chemical approach should aim at exerting solvent mimicry and achievingminimal selectivity to probe the protein surface regardless of its chemical nature. The choice ofthe photoreagent diazirine to fulfill these goals arises from its size comparable to water and frombeing a convenient source of the extremely reactive methylene carbene (:CH2). The ensuingmethylation depends primarily on the solvent accessibility of the polypeptide chain, turning it intoa valuable signal to address experimentally the measurement of SASA in proteins. The superbsensitivity and high resolution of modern mass spectrometry techniques allows us to derive aquantitative signal proportional to the extent of modification (EM) of the sample. Thus, diazirinelabeling coupled to electrospray mass spectrometry (ESI-MS) detection can shed light onconformational features of the native as well as non-native states, not easily addressable byother methods. Enzymatic fragmentation of the polypeptide chain at the level of small peptidesallows us to locate the covalent tag along the amino acid sequence, therefore enabling theconstruction of a map of solvent accessibility. Moreover, by subsequent MS\/MS analysis ofpeptides, we demonstrate here the feasibility of attaining amino acid resolution in defining thetarget sites.","palabras_clave":"diazirine|ESI-MS|solvent accessibility|protein structure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2233,"idioma_id":4,"titulo":"Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities","resumen":"                                                        Twelve new hydroquinones and quinones (4a-c \u2013 7a-c) derived from free or peracetylated bile acids were prepared by a Barton decarboxylation reaction, with subsequent trapping of the resulting free radical by benzoquinone. All new compounds were completely characterized by 2D NMR techniques and screened for antifungal and cytotoxic activity. One of the new hydroquinones (7b) showed promising preliminary results against the human pancreatic ductal carcinoma cell line PANC1, with similar cytotoxic activity than the commercial chemotherapy drug doxorubicin.                                                       ","palabras_clave":"bile acids |Barton decarboxylation reaction|antifungal activity| cytotoxic activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2236,"idioma_id":4,"titulo":"Effect of lyophilization and storage temperature on the activity of salivaricin CRL 1328, a potential bioactive ingredient of a urogenital probiotic product","resumen":"Bacteriocins are antimicrobial peptides with potential applications as therapeutic agents for the treatment of microbial infections. The aim of this work was to investigate the effect of different protectors on the activity of salivaricin CRL1328, a bacteriocin produced by Lactobacillus salivariusCRL1328, during the lyophilization process and subsequent storage at different temperaturesfor 18 months using statistical models. Different protectors such as mannitol, Tween 80,polyethylene glycol 8000 (PEG), monosodium glutamate (MSG), reconstituted skim milk, sucroseand ascorbic acid were used for the lyophilization and storage of salivaricin. The biplot ofprincipal component analysis was used for the interpretation of the interactions between the differentfactors studied. The antimicrobial activity of salivaricin was dependent mainly on temperature,and also on the time of storage and protector assayed. The stability of salivaricin was higher at &#65533;&#65533;20&#65533;&#65533;C and 4&#65533;&#65533;C than 25&#65533;&#65533;C and decreased during the time of storage; however, salivaricinwas active after 18 months of storage at 25&#65533;&#65533;C. Sucrose, mannitol plus sucrose, PEG plus sucroseand MSG were the most effective agents in protecting the bacteriocin during the lyophilizationprocess. Effective maintenance of the activity of the bacteriocin was observed by storage withsucrose and ascorbic acid at &#65533;&#65533;20&#65533;&#65533;C as well as with PEG plus sucrose at 4&#65533;&#65533;C and &#65533;&#65533;20&#65533;&#65533;C. The resultsobtained suggest that sucrose alone or combined with PEG can effectively maintain theactivity of salivaricin during lyophilization and storage. This study provides useful informationfor the potential application of salivaricin as a bioactive principle for a pharmaceutical formulation.","palabras_clave":"ANTIMICROBIAL PEPTIDE|BACTERIOCIN STORAGE|LACTOBACILLUS SALIVARIUS CRL 1328|SALIVARICIN CRL 1328|UROGENITAL INFECTION BIOPHARMACEUTICAL PRODUCT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2255,"idioma_id":4,"titulo":"Changes in soil carbon and nitrogen with afforestation across gradients of precipitation and plantation age","resumen":"Afforestation, the conversion of unforested lands to forests, is a tool for  sequestering anthropogenic carbon dioxide into plant biomass. However, in addition to  altering biomass, afforestation can have substantial effects on soil organic carbon (SOC) pools,  some of which have much longer turnover times than plant biomass. An increasing body of  evidence suggests that the effect of afforestation on SOC may depend on mean annual  precipitation (MAP). The goal of this study was to test how labile and bulk pools of SOC and  total soil nitrogen (TN) change with afforestation across a rainfall gradient of 600 to 1500 mm in  the Rio de la Plata grasslands of Argentina and Uruguay. The sites were all former grasslands  planted with Eucalyptus spp. Overall, we found that afforestation increased (up to 1012 kg  Cha1yr1) or decreased (as much as 1294 kg Cha1yr1) SOC pools in this region and that  these changes were significantly related to MAP. Drier sites gained, and wetter sites lost, SOC  and TN (r2=0.59, p=0.003; and r2=0.57, P=0.004, respectively). Labile C andNin microbial  biomass and extractable soil pools followed similar patterns to bulk SOC and TN.  Interestingly, drier sites gained more SOC and TN as plantations aged, while losses reversed  as plantations aged in wet sites, suggesting that plantation age in addition to precipitation is a  critical driver of changes in soil organic matter with afforestation. This new evidence implies  that longer intervals between harvests for plantations could improve SOC storage, ameliorating  the negative trends found in humid sites. Our results suggest that the value of afforestation as a  carbon sequestration tool should be considered in the context of precipitation and age of the  forest stand.","palabras_clave":"afforestations|soil|carbon"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2267,"idioma_id":5,"titulo":"Catolicismo y condición femenina: representaciones de género sobre la maternidad y la domesticidad en la prensa del sudoeste bonaerense argentino a principios del siglo XX","resumen":"En el presente artículo se identifican y describen los significados atribuidos a la maternidad y a la domesticidad analizando las representaciones de género en el discurso de la prensa confesional que aparece en Bahía Blanca y circula por su zona de influencia en las tres primeras décadas del siglo XX. Se sostiene que los\/as católicos\/as que escriben en la prensa comparten el concepto de diferencia sexual dominante y abordan el problema de la condición femenina centrándose en las nociones de domesticidad y maternidad, que aluden al rol de reproducción material y biológica de la sociedad en el marco de la división sexual del trabajo. Sin embargo, algunos de ellos las reformulan frente a las transformaciones epocales que impactan sobre la familia, como resultado de lo cual expresan ideas que, si bien no tienen en sí mismas la intención de subvertir las relaciones de género, avalan ciertas mutaciones de signo moderno.","palabras_clave":"CATOLICISMO|PRENSA|MATERNIDAD|DOMESTICIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2273,"idioma_id":4,"titulo":"Chemical reaction systems with toric steady states","resumen":"Mass-action chemical reaction systems are frequently used in ComputationalBiology. The corresponding polynomial dynamical systems are often large(consisting of tens or even hundreds of ordinary differential equations) andpoorly parametrized (due to noisy measurement data and a small number of datapoints and repetitions). Therefore, it is often difficult to establish theexistence of (positive) steady states or to determine whether more complicatedphenomena such as multistationarity exist. If, however, the steady state idealof the system is a binomial ideal, then we show that these questions can beanswered easily. The focus of this work is on systems with this property, andwe say that such systems have toric steady states. Our main result givessufficient conditions for a chemical reaction system to have toric steadystates. Furthermore, we analyze the capacity of such a system to exhibitpositive steady states and multistationarity. Examples of systems with toricsteady states include weakly-reversible zero-deficiency chemical reactionsystems. An important application of our work concerns the networks thatdescribe the multisite phosphorylation of a protein by a kinase\/phosphatasepair in a sequential and distributive mechanism.","palabras_clave":"Chemical reaction network|binomial ideal|steady state|multistationarity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2282,"idioma_id":4,"titulo":"Crustal deformation of the Andean foreland at 31º 30´ S (Argentina) constrained by magnetotelluric survey","resumen":"Vease adjunto","palabras_clave":"Magnetotellurics|Flat slab|Sierras Pampeanas|Terranes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2291,"idioma_id":4,"titulo":"Active power control of a flywheel energy storage system for wind energy applications","resumen":"The integration of wind power generation in power systems is steadily increasing around the world. This incorporation can bring problems onto the dynamics of power systems owing to the lack of controllability over the wind and the type of generation used. In this work, a distribution static synchronous compensator (DSTATCOM) coupled with a flywheel energy storage system (FESS) is used to mitigate problems introduced by wind generation in the electric system. A dynamic model of the DSTATCOM\/FESS device is briefly presented and a technique to control the active power exchanged between the device and the power system is proposed. The control technique is based on fuzzy logic and a special filter. Tests of the behaviour of the device are analysed when combined with wind generation in the electric system. Results show an overall satisfactory performance of the proposed control technique along with the high effectiveness of the device used to smooth the active power fluctuations of a wind generator.","palabras_clave":"Power systems|Wind energy|Integration|Dynamic problems|Mitigation|Flywheel energy storage|Distribution static synchronous compensator|Dynamic model|Active power control|Fuzzy logic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2295,"idioma_id":4,"titulo":"ESTIMACIÓN DE MASA DE LAS ESPECIES DE SPARASSODONTA (MAMMALIA, METATHERIA) DE LA EDAD SANTACRUCENSE (MIOCENO TEMPRANO) A PARTIR DEL TAMAÑO DEL CENTROIDE DE LOS ELEMENTOS APENDICULARES: INFERENCIAS PALEOECOLÓGICAS","resumen":"          Sparassodonts have been described as a group with a large body-mass  diversity, but few works had focused on the body mass estimations. In this  contribution, we calculated the centroid size of the anterior view of the  distal humerus, lateral view of the proximal ulna, and proximal articular view  of the tibia. These data together with the known body-mass for many current predators  (marsupials and placentals) allowed to obtain new allometric equations to  estimate body size in extinct mammalian carnivores (i.e., Sparassodonta). Using  comparative analyses, we quantified the effect of the phylogenetic structure  over the equations. The relationship between body mass, centroid size, and  locomotory habits was explored. The phylogenetic effect was significant for all  regressions. In the humerus analysis, we found an important relationship  between body mass and locomotory habit, suggesting adaptive causes for this  pattern. We used the ulna and tibia regressions to predict body mass, since  they were less influenced by locomotory habits. We obtained the following masses:  Arctodictis sinclari Marshall, 39.9 kg; Borhyaena  tuberata Ameghino, 36.4   kg; Cladosictis patagonica Ameghino, 6.6 kg; Lycopsis  longirostrus Marshall, 29.77   kg; Prothylacynus patagonicus Ameghino, 31.79 kg; Sipalocyon  gracilis Ameghino, 2.11   kg; and Thylacosmilus atrox Riggs, 117.36 kg. For Borhyaena and Thylacosmilus, we obtained numbers higher than previously published  masses, while for Pseudonotictis pusillus  Ameghino, we made the first body mass estimation: 1.17 kg. The results  suggest that the guild of the santacrucian predators was structured by the body  mass, but other niche variables, such as diet and locomotion, were also  relevant factors.","palabras_clave":"Tamaño corporal|Sparassodonta|América del Sur|Cenozoico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2303,"idioma_id":5,"titulo":"POLÍTICAS DE PROTECCIÓN SOCIAL  Y PARTICIPACIÓN ECONÓMICA DE LA POBLACIÓN  EN ARGENTINA (2003-2010)","resumen":"Durante el período 2003 ? 2010 la oferta de trabajo en Argentina se mantuvo prácticamente inalterada. Tal comportamiento contrasta con la sensible mejora de las oportunidades de empleo constatadas en la economía con posterioridad a la gran crisis 2001-2002. Ante ello se justifica indagar si tal evolución pudo haber sido el resultado de las medidas de protección social basadas en transferencias de ingresos que se instrumentaron en el período. Aun cuando la controversia en torno a los efectos que las entregas de dinero tienen sobre las decisiones de participación en el mercado de trabajo ocupa una parte importante de la agenda de investigación social, el caso argentino ha estado escasamente tratado en la literatura especializada.   En este documento se analizaron los determinantes de egresar ? ingresar a la actividad económica para la población beneficiaria de los dos mayores programas de transferencias de ingresos implementados en el país: el Plan de Inclusión Previsional y la Asignación Universal por Hijo. Los datos utilizados provinieron de la Encuesta Permanente de Hogares que releva el Instituto Nacional de Estadística y Censos ?EPH-INDEC? con los cuales se produjeron las estimaciones econométricas.   Los resultados obtenidos confirmaron que tales esquemas de protección social no ocasionaron el retiro de la actividad económica de los beneficiarios. Por el contrario, un hallazgo de la investigación es que tales políticas alentaron el ingreso al mercado laboral de algunos de los miembros de los hogares beneficiarios.","palabras_clave":"PROTECCIÓN SOCIAL|OFERTA DE TRABAJO|REGRESIÓN MULTINOMIAL LOGÍSITICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2315,"idioma_id":4,"titulo":"Dynamics of pleustonic ostracod populations in small ponds on the Island of Mart&#305;´n Garc&#305;´a (R&#305;´o de la Plata, Argentina)","resumen":"The biogeography and ecological preferences of Neotropical freshwater ostracods are poorly known, and more so the dynamics of populations and  habitat selection of species living in pleustonic environments of temporary ponds. In the present survey we analyze the population changes of ostracods living in pleustonic environments of small freshwater bodies on Mart&#305;´n Garc&#305;´a Island (R&#305;´o dela Plata, Argentina). Between June 2005 and June 2007, monthly samples of floating vegetation from eight different ponds on the island were collected, and limnological parameters were measured in situ. The results of multivariate logistic regression showed that the presence of ostracods was significantly related to high dissolved oxygen content and high water temperature. In addition, multivariate regression analysis indicated that, when ostracods were  present, their total abundance was negatively related to floating vegetation dry weight. Four ostracod species were found: Strandesia bicuspis, Chlamydotheca incisa, Cypridopsis vidua, and Bradleytriebella  trispinosa. The seasonal variation in abundances indicated that populations of the most common species, S. bicuspis and C. incisa, were denser during the summer and autumn months. The results of canonical correspondence analysis showed that individuals of S. bicuspis were more abundant at higher temperatures and lower conductivity than C. incisa.  Further research is needed to clarify the observed negative correlation between floating vegetation dry weight and ostracod density and the possible differential thermal preference of the two species studied.","palabras_clave":"OSTRACODA|PHENOLOGY|TEMPORARY PONDS|ECOLOGICAL PREFERENCES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2321,"idioma_id":4,"titulo":"Comparative Study of Lead Accumulation in Different Organs of the Freshwater Crab Zilchiopsis oronensis","resumen":"Lead is known as an important aquatic contaminant with different toxic effects on various organisms. Until now, only few quantitative investigations have been published comparing Pb content in different organs of adult freshwater crabs. Their capacity to bioaccumulate other heavy metals is already known, and they have potential to transfer Pb to the terrestrial systems as they are frequent trophic items of reptiles and birds, even humans.   The objectives of this study were to assess Pb accumulation in gills, carapace, digestive gland and quela muscle of the freshwater crab Zilchiopsis oronensis, and to correlate bioaccumulation with morphometric data and sex.  The crabs were manually caught in non-polluted ponds of the middle Paraná River alluvial valley (Santa Fe, Argentina). After the acclimation period, they were individually and randomly exposed per quatriplicate to three Pb experimental doses, 20, 40 and 80 mgPb\/l, in plastic cages during 15 days. After dissecting the crabs, the tissues were analyzed for lead in a Perkin Elmer Analyst 800 atomic absorption spectrometer.  We found significant differences (p0.05) and highly significant differences (p<0.0001) between Pb concentration in organs. The Tukey post test showed significant differences (p<0.05) between gills-carapace, gills-digestive gland and gills-quela muscle.   The weight of the crabs only showed a negative correlation with Pb in quela muscle (r=-0.53; p=0.03). Pb in carapace (but not in the other tissues) was positive correlated with width (p = 0.571) and length (p= 0.616). Males accumulated more Pb than females, though not significantly. The present paper is aimed to contribute to our knowledge on Pb accumulation in freshwater crabs and select the better indicator organisms for biomonitoring.","palabras_clave":"HEAVY METALS|LEAD ACCUMULATION|FRESHWATER|CRABS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2343,"idioma_id":4,"titulo":"Molecular identification of Contracaecum pelagicum (Nematoda: Anisakidae) from the anchovy Engraulis anchoita (Engraulidae) and fish-eating birds from Argentinian North Patagonian Sea, with larval morphological description","resumen":"AbstractAnisakids use invertebrates as paratenic or intermediate hosts as a basic feature onlarval transmission. The third-stage larva usually develops in invertebrates which are preyitems of vertebrate paratenic hosts as fishes. Contracaecum larvae moult twice insideeggs and hatch as free third-stage larvae ensheated in the second-stage larva cuticle.Copepods act as paratenic or obligated host usually ingesting these free L3 larvae andfish would act as paratenic or metaparatenic host preying on infected copepods. Fisheatingbirds acquire L3 larvae ingesting infected fish developing the fourth-stage larvaeand adults. Objective of this work was to establish the specific correspondence betweenContracaecum larvae moult twice insideeggs and hatch as free third-stage larvae ensheated in the second-stage larva cuticle.Copepods act as paratenic or obligated host usually ingesting these free L3 larvae andfish would act as paratenic or metaparatenic host preying on infected copepods. Fisheatingbirds acquire L3 larvae ingesting infected fish developing the fourth-stage larvaeand adults. Objective of this work was to establish the specific correspondence betweenC. pelagicum L3 larvae parasitizing the anchovy Engraulis anchoita, and the adultsparasitizing the Magellanic penguin Spheniscus magellanicus and the Imperial shagL3 larvae parasitizing the anchovy Engraulis anchoita, and the adultsparasitizing the Magellanic penguin Spheniscus magellanicus and the Imperial shagSpheniscus magellanicus and the Imperial shagPhalacrocorax atriceps through the use of molecular markers. Sixteen specimens ofthrough the use of molecular markers. Sixteen specimens ofContracaecum L3 larvae were analyzed from E. anchoita from Bahía Engaño, Chubut,eight adult nematodes from S. magellanicus and six adult specimens from Ph. atricepsL3 larvae were analyzed from E. anchoita from Bahía Engaño, Chubut,eight adult nematodes from S. magellanicus and six adult specimens from Ph. atricepsS. magellanicus and six adult specimens from Ph. atricepsboth from Península Valdés, Chubut. All nematodes were sequenced for three genes:mitochondrial cytochrome oxidase 2 (mtDNA cox2), mitochondrial ribosomal RNA(rrnS), and the internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomalDNA regions. Phylogenetic analyses were performed by using Maximum Parsimony(MP) analysis by PAUP, Akaike Information Criterion (AIC) by Modeltest 3.6. Also,studies under SEM and OM were done on L3 larvae. All L3 larvae individuals from E.anchoita, adults from S. magellanicus, and Ph. atriceps clustered in the same clade wellsupported in the MP tree inferred from the mtDNA cox2, and rrnS gene sequencescox2), mitochondrial ribosomal RNA(rrnS), and the internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomalDNA regions. Phylogenetic analyses were performed by using Maximum Parsimony(MP) analysis by PAUP, Akaike Information Criterion (AIC) by Modeltest 3.6. Also,studies under SEM and OM were done on L3 larvae. All L3 larvae individuals from E.anchoita, adults from S. magellanicus, and Ph. atriceps clustered in the same clade wellsupported in the MP tree inferred from the mtDNA cox2, and rrnS gene sequencesrrnS), and the internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomalDNA regions. Phylogenetic analyses were performed by using Maximum Parsimony(MP) analysis by PAUP, Akaike Information Criterion (AIC) by Modeltest 3.6. Also,studies under SEM and OM were done on L3 larvae. All L3 larvae individuals from E.anchoita, adults from S. magellanicus, and Ph. atriceps clustered in the same clade wellsupported in the MP tree inferred from the mtDNA cox2, and rrnS gene sequencesE.anchoita, adults from S. magellanicus, and Ph. atriceps clustered in the same clade wellsupported in the MP tree inferred from the mtDNA cox2, and rrnS gene sequences, adults from S. magellanicus, and Ph. atriceps clustered in the same clade wellsupported in the MP tree inferred from the mtDNA cox2, and rrnS gene sequencescox2, and rrnS gene sequences*ManuscriptClick here to view linked Referencesanalysis. Further, the sequence alignments of L3 larvae and adults of C. pelagicum hereobtained at the ITS-1 and ITS-2 regions of the rDNA were found to be distinct from thoseso far obtained in other Contracaecum spp. genetically characterized. The MP treestopologies obtained from mtDNA cox2 and rrnS genes demonstrated that specimens ofC. pelagicum hereobtained at the ITS-1 and ITS-2 regions of the rDNA were found to be distinct from thoseso far obtained in other Contracaecum spp. genetically characterized. The MP treestopologies obtained from mtDNA cox2 and rrnS genes demonstrated that specimens ofContracaecum spp. genetically characterized. The MP treestopologies obtained from mtDNA cox2 and rrnS genes demonstrated that specimens ofcox2 and rrnS genes demonstrated that specimens ofContracaecum L3 larvae from E. anchoita and C. pelagicum from S. magellanicus aswell as from Ph. atriceps constitute a unique clade, well-distinct and supported from allthe others formed by the Contracaecum spp. sequenced so far for these genes. Molecularmarkers are considered to be an effective tool to elucidate larval transmission.L3 larvae from E. anchoita and C. pelagicum from S. magellanicus aswell as from Ph. atriceps constitute a unique clade, well-distinct and supported from allthe others formed by the Contracaecum spp. sequenced so far for these genes. Molecularmarkers are considered to be an effective tool to elucidate larval transmission.Ph. atriceps constitute a unique clade, well-distinct and supported from allthe others formed by the Contracaecum spp. sequenced so far for these genes. Molecularmarkers are considered to be an effective tool to elucidate larval transmission.Contracaecum spp. sequenced so far for these genes. Molecularmarkers are considered to be an effective tool to elucidate larval transmission.","palabras_clave":"Molecular markers|larval transmission|Contracaecum pelagicum|Engraulis anchoita paratenic host"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2349,"idioma_id":5,"titulo":"Un avance en el programa de mejoramiento académico de la Facultad de Ciencias Médicas","resumen":"Un avance en el programa de mejoramiento académico de la Facultad de Ciencias Médicas.","palabras_clave":"EDUCACION|UNIVERSIDAD|ARTICULACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2365,"idioma_id":5,"titulo":"LOS DERECHOS HUMANOS DE LAS MUJERES DURANTE LA MASACRE DE PANDO ? BOLIVIA Y UNASUR","resumen":"Se analizará la violación a los derechos humanos de las mujeres en la masacre de Pando, Bolivia, sucedida el 11 de septiembre de 2008, para lo cual se detendrá en un caso testigo, el de Lucía Fátima da Silva. Se observará la construcción simbólica por parte de equipos técnicos que tuvieron y tienen intervención en la zona afectada, y de activistas políticos\/as bolivianos\/as, en relación al tema. UNASUR, como bloque regional, funda su acción en la actuación frente a la masacre de Pando, se preguntará en qué medida fueron contemplados los derechos humanos de las mujeres y cuáles son los límites y avances institucionales que permitan realizar acompañamientos técnico - profesionales. ","palabras_clave":"UNASUR|DERECHOS HUMANOS|VIOLENCIA DE GÉNERO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2371,"idioma_id":5,"titulo":"Factores institucionales del logro en matemática en la educación media de argentina, 1998-2007: una actualización","resumen":"Este artículo consta de tres partes. En la primera se investigan las relaciones entre la 'composición' estudiantil de la escuela socioeconómica, académica, género), algunas características del proceso escolar ('ethos' y 'clima' escolar), según las percepciones del Director y las percepciones 'agregadas' de los alumnos, y el rendimiento en Matemática de los alumnos del último año del Secundario en Argentina. Se analizan los datos del Censo Nacional de Finalización del Nivel Secundario de 1998 (Ministerio de Educación). Se utiliza la técnica de 'análisis estadístico multinivel' con tres niveles (alumnos, escuela y provincia). Inicialmente, se detecta una estrecha asociación entre el rendimiento en Matemática y las variables de proceso escolar. Cuando se 'controla' por la 'composición' de la escuela, las actitudes y autoconceptos de los alumnos continúan manteniendo un efecto importante, mientras que las percepciones (del Director y de los alumnos) sobre los procesos institucionales dejan de tener efecto propio. En la segunda parte, el análisis de algunas variables de proceso institucional extraídas del cuestionario del Director aplicado en el Operativo Nacional de Evaluación (2007) del último año del nivel secundario, confirma algunos de los hallazgos informados en la primera parte. Finalmente, los datos del Censo 1998 se reanalizan con modelos multinivel donde se adiciona el aula como otro nivel de agregación. Se discuten las implicaciones de los resultados obtenidos en relación a las dos partes anteriores.","palabras_clave":"Rendimiento en matemáticas|educación secundaria|factores escolares|, Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2374,"idioma_id":5,"titulo":"Introducción al Dossier 'Historia de las relaciones entre la Argentina y el Fondo Monetario Internacional'","resumen":"Aunque la relación entre el FMI y la Argentina data de mediados de siglo XX, los análisis se han demorado hasta la década del ?80 y, aun desde entonces, es notable la escasez de trabajos sistemáticos al respecto. El presente dossier, integrado por tres trabajos de Noemí Brenta, Ignacio Labaqui y Pablo Nemiña, busca ampliar la comprensión del sentido histórico del vínculo entre la Argentina y uno de los actores externos clave en la evolución de la economía política doméstica.","palabras_clave":"Relaciones FMI - Argentina|Historia|Condicionalidades|Economía Política"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2422,"idioma_id":4,"titulo":"IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR","resumen":"Triple negative breast cancer (TNBC) patients are not likely to benefit from anti-estrogen or anti-HER2 therapy and this phenotype is associated with a more aggressive clinical course and worse clinical outcome. Taking into account the limited treatment possibilities in TNBC, the aim of the present work was to study a potential therapy based on Cetuximab-mediated immune activity by natural killer (NK) cells. We performed in vitro studies on human breast cancer (BC) cell lines, IIB-BR-G, and the in vivo metastatic variant IIB-BR-G MT. The immunohistochemical analysis showed a TNBC phenotype with high but different levels of EGFR expression on each cell line, measured by flow cytometry. DNA sequencing showed that both cell lines have a mutated K-RAS status, 38 G&nbsp;&gt;&nbsp;A at codon 13. Consequently, Cetuximab did not inhibit cellular proliferation or induce apoptosis. We investigated if Cetuximab could trigger immune mechanisms, and we determined that both cell lines treated with 1&nbsp;ìg\/ml Cetuximab were susceptible to antibody dependent cellular cytotoxicity (ADCC), mediated by peripheral blood mononuclear cells (PBMC). At 50:1 effector:target ratio, lytic activity was 34&nbsp;±&nbsp;2% against IIB-BR-G and 27&nbsp;±&nbsp;6% against IIB-BR-G MT cells. PBMC pretreatment with IL-2 allowed reaching 65&nbsp;±&nbsp;3% of Cetuximab-mediated ADCC against IIB-BR-G and 63&nbsp;±&nbsp;6.5% against IIB-BR-G MT. Furthermore, IL-15 pretreatment increased the ADCC up to 71&nbsp;±&nbsp;3% in IIB-BR-G and 79&nbsp;±&nbsp;3.5% in IIB-BR-G MT. We suggest that NK cells are the effectors present in PBMC since they were able to induce ADCC at lower effector:target ratios. Besides, IL-2- and mainly IL-15-induced upregulation of NK activating receptors CD16 and NKG2D and enhanced IFN-ã production. EGFR-expressing TNBC could be killed by Cetuximab-mediated ADCC at clinically achievable concentrations. IL-15 could advantageously replace IL-2 in most of its immunologic activities, stimulating the ability to produce IFN-ã, and paralleling the up-regulation of activating receptors.","palabras_clave":"Interleukins|Cetuximab|NK|ADCC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2424,"idioma_id":5,"titulo":"Alimentación, sedentarismo y prevalencia de obesidad en estudiantes universitarios","resumen":"Volumen 69, Suplemento N° 2, Página 27, Año 2012.","palabras_clave":"Alimentación|sedentarismo |obesidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2479,"idioma_id":4,"titulo":"13.\tReponse of  Elpida tomato grafted on different rootstocks","resumen":"Reponse of  Elpida tomato grafted on different rootstocksTrabalho - 56Sessão Pretendida - Oral Categoria - Enxertia RESPONSE OF ELPIDA TOMATO GRAFTED ON DIFFERENT ROOTSTOCKS Susana Martínez;* Mariana Garbi;  Gabriela Morelli; Ricardo Andreau,; Franco Garello Faculty of Agricultural and Forest Sciences. La Plata National University. Calle 60 y 119. La Plata, Buenos Aires. Argentina. smarti@agro.unlp.edu.ar In grafted plants, the rootstock influences growth characteristics of the commercial variety grafted on it. This trial aimed to study the response of the hybrid Elpida grafted on different rootstocks. The essay was carried out in a greenhouse located in La Plata, Buenos Aires, Argentina. Transplant was performed on 9\/21\/2011, according to the following treatments: 1) Elpida without grafting (control) led to 1 branch and 2 plants.m-2 and 2) Elpida grafted on Maxifort, Arnold, Armstrong, Efialto, Baron H and RS rootstocks, conducted at 2 branches and 1 plant.m-2. The experimental design was a randomized complete block with 4 replications.  Plant height 22 days after transplant, days from transplanting to 1º flowering and 1º fruiting, total yield and fruit size were recorded. Data were subjected to analysis of variance comparing means by the Tukey test and by Kruskall Wallis test. Control plants showed higher height, reaching first flowering and fruiting a week earlier than grafted plants, with no significant differences from plants grafted on RS and H Baron rootstocks. Plants grafted on Arnold yielded 95 % more than the control group (6,2 kg.m-2 vs. 3,2 kg.m-2), followed by the plants grafted on Maxifort and Efialto (64% higher than controls). Arnold and Maxifort produced fruits of higher average weight than the control. In test conditions, grafted plants tended to show a phenological delay, nevertheless it favored crop yield, particularly the Arnold, Maxifort and Efialto varieties.","palabras_clave":"graft|tomatoe"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2506,"idioma_id":5,"titulo":"Informe de la Provincia de Mendoza correspondiente al año 2011","resumen":"resumen","palabras_clave":"INFORME|PROVINCIA|MENDOZA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2508,"idioma_id":5,"titulo":"Área cosechable y producción de caña de azúcar y azúcar para la zafra 2012 en Tucumán","resumen":"El informe resume las tareas desarrolladas por la EEAOC durante los   meses de enero a mayo de 2012 en el relevamiento de la zona cañera de   Tucumán, para realizar la estimación de superficie, producción de caña de   azúcar y de azúcar, previas al inicio de la zafra. Se realiza además un   análisis comparativo con los valores de superficie estimados para la zafra   2011.  Para la estimación de la superficie y los rendimientos culturales se utilizó  información referida a variedades y al manejo de los cañaverales de la   provincia, e imágenes satelitales correspondientes a los satélites DEIMOS-  1, IRS-P6 Resourcesat-1 y Landsat 7. Se aplicaron metodologías de   clasificación multiespectral, índice verde (Normalized Difference  Vegetation Index: NDVI) y análisis de Sistemas de Información Geográfica   (S.I.G.), complementadas con relevamientos a campo.  Los resultados alcanzados indican un crecimiento del área cañera   cosechable, del orden del 3,4%, 8.220 ha. Como consecuencia de la   menor calidad de la materia prima y de los efectos de la sequía, la   producción probable de azúcar, o su equivalente en alcohol, podría   alcanzar entre 1.290.000 y 1.090.000 t.","palabras_clave":"Teledetección|Caña de azúcar"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2526,"idioma_id":5,"titulo":"Informe sobre el ambiente de negocios en las empresas del Aglomerado Gran Santa Fe. 1er semestre 2012","resumen":"El presente trabajo tiene por finalidad la producción y difusión periódica de información referida tanto a los niveles de actividad económica como a las expectativas generales y sectoriales de los empresarios y, en general, al ambiente de negocios de las empresasradicadas en el ámbito territorial del Gran Santa Fe.Esta información resulta de utilidad tanto en ámbitos empresariales como públicos, ya que en el primer caso, permite evaluar y comparar la trayectoria y las expectativas de cada empresa en relación a la evolución del sector de actividad del cual es parte y a la del conjunto de la economía local. Esto no solo posibilita afrontar procesos de toma de decisiones a nivel de firma con un grado de información y conocimiento del escenario actual y de las expectativas sobre el futuro mucho más amplio, sino que da pie tanto a la generación de acciones colectivas sobre problemáticas que resulten comunes.Como se señaló, el presente informe permitirá también a los diferentes niveles de gobierno, a la hora de la formulación de políticas públicas, conocer los principales inconvenientes y preocupaciones que enfrenta el empresariado local como también los diversos aspectos de carácter económico, jurídico, social o político que son espacios de tensión para estos actores sociales que conforman la base de sustentación económica del territorio.En esta nueva edición semestral se integran los informes sectoriales que indican el comportamiento de algunos sectores económicos en particular. Los mismos se producen con la cooperación de varias instituciones empresariales, con cuyo esfuerzo se llega a lograr un nivel de respuesta tal que garantiza la representatividad estadística de los resultados.La estructura de organización del informe, se presenta en cuatro grandes módulos. En el primero se muestra la situación del conjunto de las empresas productoras de bienes y servicios del área de referencia a nivel global, y en los módulos siguientes se expone la situación de cuatro sectores de actividad económica: Construcción, TIC?s (Desarrollo de Software y Servicios Informáticos), Industria y Comercio (informe del sector que se presenta en esta edición por primera vez) respectivamente. Para su desarrollo se contó con la cooperación de la Delegación Santa Fe de la Cámara Argentina de la Construcción, de Santa Fe Valley y del Centro Comercial de Santa Fe, instituciones sin las cuales no se hubiese podido afrontar este desarrollo.&nbsp; ","palabras_clave":"EXPECTATIVAS|GRAN SANTA FE|SECTORES|AMBIENTE DE NEGOCIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2528,"idioma_id":4,"titulo":"Hf and Nd isotopes in Early Ordovician to Early Carboniferous granites as monitors of crustal growth in the Proto-Andean margin of Gondwana","resumen":"We report the first study integrating in situ U-Pb and Hf isotope data from magmatic zircon and whole-rock Sm-Nd isotope data for granitic rocks of the Sierras Pampeanas, Argentina, in order to evaluate the Palaeozoic growth of the proto-Andean margin of Gondwana.  Early-Middle Ordovician granitic magmatism is by far the most voluminous of the Sierras Pampeanas and represents the most significant magmatic event. These calc-alkaline  granitoids were intruded at an active continental margin. &#949;Hft values range from &#8722;3.3 to &#8722;14.7 and &#949;Ndt from &#8722;3.3 to &#8722;6.3 (t=473 Ma), with average TDM Hf and TDM Nd ranging  from 1.5 to 2.2 Ga and 1.4 to 1.7 Ga, respectively.  Middle-Late Devonian magmatism occurred in the foreland, away from the orogenic front in the west, and included F-U-REE rich A-type granites. The Achala granite, the largest batholith in the Sierras  Pampeanas, has &#949;Hft and &#949;Ndt values ranging from &#8722;3.6 to &#8722;5.8 and &#8722;4.0 to &#8722;6.5, respectively (t=369 Ma). Small scattered Early Carboniferous A-type granite plutons were intruded in a dominantly extensional setting and have &#949;Hft and &#949;Ndt values ranging from &#8722;6.7 to +2.2 and &#8722;0.5 to &#8722;3.6, respectively (t=341 Ma). The generation of Ordovician and Devonian magmas dominantly involved crustal reworking and stabilization rather than the formation of new continental crust by juvenile material accretion, whereas Carboniferous magmatism resulted in part from reworking of supracrustal material, but with variable addition of juvenile magmas.","palabras_clave":"ISOTOPES|GEOCHRONOLOGY|ZIRCON|GONDWANA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2529,"idioma_id":4,"titulo":"Assessment of the role of fluorescent root and  seed exudates in  crop plants","resumen":"Fluorescent compounds have been reported in plant leaves, having an important biological rolein the protection towards UV irradiation. It is also known that stress conditions in plants stimulatethe production of some of these compounds in their aerial portion. However, less is known abouttheir production by roots or seeds and their presence in the soil surrounding them. We report herethat, soybean, sunflowers and rapeseed produced fluorescent seed and root exudates. Phosphorusdeficiency in rapeseed stimulates the excretion of fluorescent compounds by roots, mainly chlorogenic acid and scopoletin. When the effect of the fluorescent fraction from soybean seed exudates on Macrophomina phaseolina was tested, an enhanced induction of sclerotia formation, hyphal squeezing and lysis in the mycelium was observed. The fluorescent compounds and perhaps other chemical molecules also present in exudates might constitute a transitory defense barrier against early attack by pathogens.","palabras_clave":"mineral stress|fluorescent compounds|oil crops|Macrophomina phaseolina|phenolic compounds"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2530,"idioma_id":4,"titulo":"Interplay between Hydrogen Bonding and Molecule&#8722;Substrate Interactions in the Case of Terephthalic Acid Molecules on Cu(001)  Surfaces","resumen":"The adsorption and self-assembling properties of terephthalic acid (TPA) molecules deposited on Cu(001) at room temperature have been systematically studied with both experimental and theoretical tools. The system forms two phases at room temperature: the metastable &#946;-phase and the stable (3 × 3) one. In the case of the &#946; phase, low-energy electron diffraction and scanning tunneling microscopy (STM) results indicate that it has a (9&#8730;2 × 2&#8730;2) R45° unit cell with exactly the same molecular coverage as the (3 × 3) phase. In addition, the high-resolution X-ray photoelectron-spectroscopy spectra of the O 1s core level indicate that the irreversible &#946; &#8594; (3 × 3) transition involves the following two processes: (i) deprotonation of the complete carboxyl groups remaining in the metastable phase and (ii) eventual rearrangement of the molecules into the 3 × 3 configuration. We explored possible molecular configurations for the &#946; phase with different degree of deprotonation (including structures with Cu adatoms) by means of density functional theory calculations. Our theoretical results indicate the formation of strong bonds between the O atoms in carboxylates and the Cu atoms of the surface, which causes a bending of the molecules and a buckling of the first Cu layer. In the (3 × 3) phases, we show that the bending produces observable effects in the molecular STM images. Moreover, the strong interaction between the carboxylates and the Cu atoms at the step edges drives the reorientation of the surface steps along the 100crystallographic directions.","palabras_clave":"superficies|XPS|STM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2533,"idioma_id":4,"titulo":"Approaches to Nutrient Use Efficiency of Different Strawberry Genotypes","resumen":"In annual strawberry (Fragaria x ananassa Duch.) production systems in Argentina, fertilizers are frequently applied without considering soil fertility, cultivar particularities, and nutrient use efficiency (NuUE). The objective of this study was to investigate the NuUE of different strawberry cultivars. In 2006, 2007, and 2008, field plots of \u2018Camarosa\u2019, \u2018Camino Real\u2019, \u2018Candonga\u2019, and \u2018Ventana\u2019 were fertilized at different nutrient rates. Control treatment (\u201CC\u201D) was 120 N, 70 P2O5, 220 K2O, 40 CaO, and 20 MgO (kg\/ha). In 2006, treatments were \u201CC\u201D and \u201C1.5C\u201D, in 2007, \u201CC\u201D, \u201C1.33C\u201D and \u201C1.66C\u201D, and in 2008, \u201CC\u201D, \u201C1.5C\u201D and \u201C2C\u201D. Productivity from the applied-nutrients was inversely proportional to the applied-nutrient rate, and it was higher in high-yielding cultivars (\u2018Camarosa\u2019 and \u2018Ventana\u2019). Optimal N dose (in kg\/ha) was 183, 196, 165, and 150, for \u2018Camarosa\u2019, \u2018Ventana\u2019, \u2018Camino Real\u2019, and \u2018Candonga, respectively. Apparently, NuUE is cultivar related, and might become a useful tool for adjusting fertilization programs and characterizing new cultivars in breeding programs.","palabras_clave":"Fragaria|nutrient productivity|nutrient ratio|nutrient recovery efficiency"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2535,"idioma_id":4,"titulo":"Representation dimension of cluster concealed algebras","resumen":"We are going to show that the representation dimension of a  cluster-concealed algebra B is 3. We compute its representation dimension  by showing an explicit Auslander generator for the cluster-tilted algebra.","palabras_clave":"cluster concealed|auslander-generator|complete slice|contravariantly finite"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2536,"idioma_id":5,"titulo":"Química Analítica: Aprendizaje a partir de Webquest.","resumen":"En este trabajo se pretendió determinar&nbsp;el impacto que producen las nuevas tecnologías de la información y la comunicación en alumnos que cursaron la materia y que son del Profesorado en Ciencias Químicas y del ambiente de la UNCAUS.","palabras_clave":"WEBQUEST|AGUAS|QUÍMICA ANALÍTICA|CONSTRUCTIVISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2537,"idioma_id":5,"titulo":"El paisaje del área centro-este de La Pampa: bordes, efectos de borde y ecotomo","resumen":"INDIZACIONES: Emerging Sources Citation Index; American History and Life; Historical Abstracts; DOAJ; DIALNET; LATINDEX.RESUMEN:Por medio del análisis formal del paisaje se pudo reconocer en el área de estudio una complejidad estructural vinculada, por un lado, con la presencia de un borde con efecto de ecotono y por otro, con una organización en mosaico del espacio. Este análisis permitió identificar diferentes unidades geomorfológicas, reconocer sus características, límites y predefinir potenciales usos arqueológicos de las mismas. La construcción social del paisaje ha permitido visualizar y considerar al contexto arqueológico del área como parte de un territorio mayor con el cual estaría relacionado.","palabras_clave":"PAISAJE|ARQUEOLOGÍA|ECOTOMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2539,"idioma_id":5,"titulo":"¿Quién mató a Millaman? Venganzas y guerra de ocupación nacional del Neuquén, 1882-1883","resumen":"En este artículo analizamos la relación entre las guerras mapuches y la guerra de ocupación de la Patagonia por parte del Estado argentino en el marco de la denominada >. Si bien la campaña es un tema central de la historia argentina y de la historia indígena en Argentina, fuera de elegías militares o denuncias anticoloniales, poca atención ha tenido la infrapolítica de la guerra como hecho social total. Centrándonos en la figura cruel e infame del cacique Pichi Millaman durante la ocupación del Neuquén y sus conflictos históricos con caciques vecinos, abordaremos la inserción de la guerra de conquista en la guerra mapuche, para la comprensión de las actitudes y estrategias adoptadas por los caciques neuquinos y los comandantes militares que protagonizaron la conquista. Particularmente, el modo en que dichas prácticas políticas y de guerra, como así también la historia previa de conflictos intestinos, permiten entender el desarrollo de los eventos militares generales envueltos en las ramificaciones de la Campaña del Desierto incluyendo tanto los hechos bélicos como el desarrollo ulterior de la política mapuche. Para ello trabajaremos en dos direcciones. Primero, aportaremos densidad histórica a los eventos de Pichi Millaman incorporándolos en una cadena de venganzas que se remonta al siglo XVIII y el desarrollo de la política indígeno-criolla en la frontera sur de Mendoza. Segundo, indagaremos en la política de la guerra, la alianza y la traición, atendiendo a las tácticas terroristas y el prestigio de la crueldad en la guerra indígeno-criolla, y el papel central en la misma de los saberes y prácticas geopolíticas de la baqueanía y la profanación-preservación de chenques y restos humanos.  La revista Nuevo Mundo Mundos Nuevos está incluida en los siguientes directorios y servicios de indexación y resumen: DOAJ, Hapi Online, Latindex, Fondecyt-équivalent ISI, Revues.org, INSHS-CNRS (liste des revues soutenues par l INSHS), EHESS , INIST , e-Revista Biblioteca Virtual CSIC, Catálogo CSIC, DIALNET , BASE, ERIH PLUS, Google Scholar, EZB, JournalSeek, REDIAL , SUDOC, Cibera , D História. El fil d Ariadna, History Journals Index, Biblioteca Virtual Miguel de Cervantes, AperTO","palabras_clave":"MAPUCHE|PEHUENCHE|GUERRA|CAMPAÑA DEL DESIERTO|NORDPATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2540,"idioma_id":4,"titulo":"The logic of quantum measurements","resumen":"We apply our previously developed formalism of contexts of histories, suitable to deal with quantum properties at different times, to the measurement process. We explore the logical implications which are allowed by the quantum theory, about the realization of properties of the microscopic measured system, before and after the measurement process with a given pointer value.","palabras_clave":"Contexts |Histories|Measurement"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2545,"idioma_id":4,"titulo":"The immune enhancement of a novel soy lecithin\/&#946;-glucans based adjuvant on native Neospora caninum tachyzoites extract vaccine in mice","resumen":"Efficient, cost-effective and safe Th1-immunity-inducing vaccine formulations are paramount for achieving protection against Neospora caninum. In this study, a new adjuvant (Providean-AVEC) was used in the development of a N. caninum vaccine and evaluated in a mouse model. Soluble N. caninum tachyzoite native protein extract (sNcAg) was selected as vaccine antigen based on its capacity to activate production of pro-inflammatory cytokines on dendritic cells. Vaccines containing 4 and 0.4 &#956;g of sNcAg, and Providean-AVEC, ISCOM-Matrix or aluminum hydroxide (Alum) were tested in BALB\/c mice. While mice vaccinated with 4&#956;g of sNcAg + Providean-AVEC developed specific antibodies shortly after the first dose, the rest of the high antigen payload formulations only induced seroconversion after the booster. Mice immunized with the high payload ISCOM vaccine (4 &#956;g sNcAg) or with either low or high payload Providean-AVEC formulations (0.4 &#956;g and 4 &#956;g sNcAg, respectively) elicited higher IgG2a than IgG1 serum levels, and IFN-&#947; anamnestic responses with a Th1-cytokine biased profile. These animals had no histological signs of cerebral lesions and parasite burden assessed by quantitative real-time PCR was not detected. Vaccine preparations including Providean-AVEC as adjuvant limited N. canimum multiplication even with only a tenth of antigen payload compared to vaccines containing other adjuvants. Using adjuvants to specifically activate dendritic cells, combined with a careful antigen selection can enhance cellular responses to inert N. caninum vaccines.","palabras_clave":"NEOSPORA CANINUM|ADYUVANTS|MOUSE MODEL|VACCINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2546,"idioma_id":4,"titulo":"Combined search for the Standard Model Higgs boson in pp collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":"A combined search for the Standard Model Higgs boson with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated luminosities from 4.6 fb^-1 to 4.9 fb^-1 of proton-proton collisions collected at sqrt(s) = 7 TeV in 2011. The Higgs boson mass ranges of 111.4 GeV to 116.6 GeV, 119.4 GeV to 122.1 GeV, and 129.2 GeV to 541 GeV are excluded at the 95% confidence level, while the range 120 GeV to 560 GeV is expected to be excluded in the absence of a signal. An excess of events is observed at Higgs boson mass hypotheses around 126 GeV with a local significance of 2.9 standard deviations (sigma). The global probability for the background to produce an excess at least as significant anywhere in the entire explored Higgs boson mass range of 110-600 GeV is estimated to be ~15%, corresponding to a significance of approximately one sigma.","palabras_clave":"ATLAS|High|Energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2547,"idioma_id":4,"titulo":"Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR 2\/MyD88-dependent TNF-alpha production.","resumen":"        Abstract  Osteoarticular complications are common in human  brucellosis, but the pathogenic mechanisms involved are largely unknown. In  this manuscript, we described an immune mechanism for inflammatory bone loss in  response to infection by Brucella abortus. We established a requirement for  MyD88 and TLR2 in TNF-&#945;-elicited  osteoclastogenesis in response to B. abortus infection. CS from macrophages  infected with B. abortus induced BMM to undergo osteoclastogenesis. Although B.  abortus-infected macrophages actively secreted IL-1&#946;, IL-6, and TNF-&#945;, osteoclastogenesis depended on TNF-&#945;, as CS from B. abortus-infected macrophages failed to induce osteoclastogenesis  in BMM from TNFRp55&#8315;\/&#8315; mice. CS from B. abortus-stimulated MyD88&#8315;\/&#8315; and TLR2&#8315;\/&#8315; macrophages failed to express TNF-&#945;, and these CS induced no osteoclast formation compared with that of the  WT or TLR4&#8315;\/&#8315; macrophages. Omp19, a B. abortus lipoprotein model, recapitulated the  cytokine production and subsequent osteoclastogenesis induced by the whole  bacterium. All phenomena were corroborated using human monocytes, indicating  that this mechanism could play a role in human osteoarticular brucellosis. Our  results indicate that B. abortus, through its lipoproteins, may be involved in  bone resorption through the pathological induction of osteoclastogenesis","palabras_clave":"Brucellosis|pathogenic mechanisms|Osteoarticular complications|MYD 88"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2548,"idioma_id":4,"titulo":"Surface display of AcMNPV occlusion-derived P74 does not enhance oral infectivity of budded viruses","resumen":"Baculovirus occlusion-derived viruses (ODVs) and budded viruses (BVs) are morphologically and functionally distinct. ODVs are responsible for primary infection in insect hosts because of their high per os infectivity. On the contrary, BVs poorly infect endothelial gut cells, but propagate the infection in the tissues of insects with a high efficiency. P74 is one of the most important proteins from ODVs, and it participates in the attachment of this viral phenotype to endothelial cells in the midgut. We evaluated the possibility of pseudotyping BVs of Autographa californica multiple nucleopolyhedrovirus with two versions of P74 and its effect on their oral infectivity. Both recombinant BVs contained P74 and replicated similarly to wild-type viruses. Nevertheless, the presence of P74 on the BV\u2019s surface does not enhance the oral infectivity of this phenotype, suggesting that the presence of P74 in the membrane of budded virions interferes with their mechanism of infecting midgut cells.","palabras_clave":"Baculovirus \u0002 Budded virus| P74 | \u0002Pseudotyping|Budded virus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2549,"idioma_id":4,"titulo":"PGD by aCGH and QF-PCR in a couple with recurring aneuploidies","resumen":"This case report describes a PGS study perfomed on a blastocyst stage of a 44 year old female and 46 year old male couple with a history of recurrent aneuploid abortions. The main purpose of this report is to determine, by using STRs and QF-PCR, the parental origin of the aneuploidies found on the embryos aCGH karyotype. Only one blastocyst of the eight biopsed resulted cytogenetically normal and it was transferred in a deferred cycle. The patient achieved the pregnancy and delivered at term a normal male child. In 30 of the 38 aneuploidies identified we could determine the parental origin: eight maternal trisomies, eight paternal trisomies and 14 maternal monosomies. Five of the eight maternal trisomies showed an allelic pattern malsegregation 1:1:1 and three showed the pattern 2:1. The same segregation patterns were observed for the paternal origin trisomies. We conclude that the aneuploidies were contributed by both members of the couple in equal proportions. This outcome compels us to reflect that caution is required when we are offering oocyte donation in a women older than 40 years who has a partner of the similar age","palabras_clave":"PGS|TROPHECTODERM BIOPSY|ADVANCED PATERNAL AGE|RECURRENT ABORTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2550,"idioma_id":4,"titulo":"Production and Biochemestry-Molecular Analysis of Microbial Community Fermenting Whey as a Potencial Probiotic for use animals","resumen":"The aims of this work were: To achieve a simple and low cost propagation   of potential probiotic agents using plain whey as a culture medium,   study the diversity of the members of the bacterial community (MC) in   plain whey and to evaluate the probiotic capacity of this MC. After a   systematic selection of agents according to their growing capacity in   whey, the constituted MC was considered as a unit. Biochemical   characterization of the lactic acid bacteria were performed using the   API system. Molecular characterization of the lactic acid bacteria was   realized using AFLP? DNA-fingerprinting, partial 16S rDNA sequence   analysis and PCR-denaturing gradient gel electrophoresis (PCR-DGGE). The   physiological characterization of yeast was determined with the   automated microplate method Allev\/Biolomics and using yeast   charac-terization system based on standard taxonomic criteria. The   identification molecular was realized by PCR-fingerprinting. The   resistance of MC to pH and bile salts were evaluated. The MC was   composed of agents from different separated Dominium like Bacteria   (Lactobacillum) and Eukaria (yeast). They are multispecies and also   multistrain assuring high biodiversity. The MC grew at low pH and   different concentrations bile salts.","palabras_clave":"Probiotic; |Multispecies; | Multistrain; |Plain Whey"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2552,"idioma_id":4,"titulo":"Hrpm is involved in glucan biosynthesis, biofilm formation and pathogenicity in Xanthomonas citri subsp. citri.","resumen":"Xanthomonas citri ssp. citri (Xcc) is the causal agent of citrus canker. This bacterium develops a characteristic biofilm on both biotic and abiotic surfaces. A biofilm-deficient mutant was identified in a screening of a transposon mutagenesis library of the Xcc 306 strain constructed using the commercial Tn5 transposon EZ-Tn5  Tnp Transposome (Epicentre). Sequence analysis of a mutant obtained in the screening revealed that a single copy of the EZ-Tn5 was inserted at position 446 of hrpM, a gene encoding a putative enzyme involved in glucan synthesis. We demonstrate for the first time that the product encoded by the hrpM gene is involved in &#946;-1,2-glucan synthesis in Xcc. A mutation in hrpM resulted in no disease symptoms after 4 weeks of inoculation in lemon and grapefruit plants. The mutant also showed reduced ability to swim in soft agar and decreased resistance to H 2 O 2 in comparison with the wild-type strain. All defective phenotypes were restored to wild-type levels by complementation with the plasmid pBBR1-MCS containing an intact copy of the hrpM gene and its promoter. These results indicate that the hrpM gene contributes to Xcc growth and adaptation in its host plant.","palabras_clave":"Xanthomonas|Biofilm|Cyclic glucans|Pathogenicity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2627,"idioma_id":4,"titulo":"Spectroscopic Studies of Vanadium Biosorption on Different Types of Carbohydrates Biomass","resumen":"Abstract: The biosorption potential of different types of carbohydrate biomass is investigated to evaluate their application to purify water contaminated by vanadium in environmentally relevant oxidation states (VIV and VV). Spectroscopic studies were done by electron paramagnetic resonance (EPR), vanadium nuclear magnetic resonance (51V NMR), circular dichroism (CD), and electronic absorption in the visible range (vis). Both D-galacturonic and D-glucuronic acids are major components of plant cellular wall polysaccharides. The interaction of VIV with the model ligands D-galacturonic and D-glucuronic acids showed that complexation starts at low pH values (pH 3) and that carboxylate and sugar?OH groups, as well as water molecules, are involved in the coordination. At pH &gt; 4.5, coordination promotes the sugar?OH deprotonation and new species form with the ligand chelating the metal ion via oxygen atoms of carboxylate and of adjacent sugar?O&#8722; donors. The studies with pectin and citric acid show the ability of both compounds to partially reduce VV to VIV in solution and the EPR parameters suggest coordination of carboxylate, sugar?OH, and water molecules. The interaction of VV with biomass from different sources shows that grapefruit, orange peel, and plane tree fruit are the most suitable candidates for the biosorption of vanadium. Studies with VV and grapefruit (or the grainless stalk of corn) indicate that the reduction takes place at the ?surface? of the solid. EPR studies on the interaction of VIV with different carbohydrate biomass show their ability to complex high amounts of VIV. We propose that the biosorption mechanism, when the biomass is in contact with VV species, involves sorption, reduction, and retention at the surface level of VIV coordinated by oxygen donors of the biomass. When the interaction starts with VIV, the main process just involves the uptake of the metal ion at the surface level.Résumé : On a étudié le potentiel de biosorption de divers types d´hydrates de carbones de la biomasse dans le but d´évaluer leur application dans la purification de l´eau contaminée par le vanadium dans les états d´oxydation pertinents a` l´environnement (VIV et VV). Les études spectroscopiques ont été faites a` l´aide de la résonance paramagnétique électronique (RPE), la résonance magnétique nucléaire du vanadium (RMN du 51V), le dichroïsme circulaire et l´absorption électronique dans la place du visible (Vis). Les acides d-galacturonique et d-glucuronique sont les composants majeurs des polysaccharides des parois des plantescellulaires. L´interaction entre le VIV avec les ligands modèles des acides d-galacturonique et d-glucuronique a montré que la complexation commence a` des valeurs basses de pH (pH, 3) et que les groupes carboxylate et OH des sucres ainsi que les molécules d´eau sont impliquées dans la coordination. À des pH supérieurs a` 4,5, la coordination favorise la déprotonation du OHdu sucre et la formation de nouvelles formes dans lesquelles le ligand se chélate a` l´ion métallique par le biais les atomes d´oxygène du carboxylate et les O- des sucres adjacents. Les études avec de la pectine et de l´acide citrique mettent en évidence la capacité de ces deux composés a` réduire partiellement le VV et VVI en solution et les paramètres de la RPE suggèrent qu´il s´effectue des coordinations au niveau des carboxylates, des OH des sucres et des molécules d´eau. L´interaction entre le VV avec la biomasse de diverses sources montre que les pamplemousses, les pelures d´orange et le fruit du platane sont les meilleurscandidats pour la biosorption du vanadium. Des études avec le VV et le pamplemousse (ou les épis de blé d´Inde sans grain) indiquent que la réduction se produit a` la surface du solide. Les études RPE de l´interaction du VIV avec diverses biomasses d´hydrates de carbone montreur leur facilité a` complexer de grandes quantités de VIV. Il est donc suggérer que le mécanisme de biosorption - quand la biomasse est en contact d´espèces VV - implique une sorption, une réduction et une rétention au niveau de la surface du V!V retenu par des coordinations avec des donneurs oxygène de la biomasse. Quand l´interaction commence avec le VIV, le processus principal implique seulement une insertion de l´ion métallique au niveau de la surface.","palabras_clave":"VANADIUM|BIOSORPTION|BIOMASS|EPR|D-GLUCURONIC ACID|D-GALACTURONIC ACID"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2629,"idioma_id":4,"titulo":"Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A","resumen":"In this study, we contrasted the hypothesis that maternal diet during pregnancy has an impact on fetal metabolic programming through changes in liver mitochondrial DNA (mtDNA) content and transcriptional activity of Ppargc1a and that these effects are sex specific. METHODS: Rats were fed either high-fat (HFD) or standard chow diet (SCD) during gestation and lactation. The resulting adult male and female offspring were fed either HFD or SCD for an 18-week period, generating eight experimental groups. RESULTS: Maternal HFD feeding during pregnancy is associated with a decreased liver mtDNA copy number (PExternal link. Please review our privacy policy.","palabras_clave":"FETAL PROGRAMMING|HIGH-FAT DIET|MITOCHONBDRIAL DNA|LIVER|PPARGC1A|METBOLIC SYNDROME"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2637,"idioma_id":4,"titulo":"BIOMECHANICAL PROPERTIES OF THE MANDIBLE, AS ASSESSED BY BENDING TESTS, IN RATS FED A LOW- QUALITY PROTEIN","resumen":"Objective: The present study describes the effects of feeding growing rats with diets containingincreasing concentrations of wheat gluten (a low quality protein, G) on both themorphometrical and the biomechanical properties of the mandible.Design: Female rats were fed one of six diets containing different concentrations (5\u201330%) ofG between the 30th and 90th days of life. Control rats were fed a diet containing 20% casein(C), which allows a normal growth and development of the bone. Mandibular growth wasestimated directly on excised and cleaned bones by taking measurements between anatomicalpoints. Mechanical properties of the right hemimandibles were determined by usinga three-point bending mechanical test to obtain a load\/deformation curve and estimate thestructural properties of the bone. Bone material properties were calculated from structuraland geometric properties. The left hemimandibles were ashed and the ash weight obtained.Calcium content was determined by atomic energy absorption. Results were summarised asmeans  SEM. Comparisons between parameters were performed by ANOVA and post-test.Results: None of the G-fed groups could achieve a normal growth performance as comparedto the C-fed control group. Like body size, age-related increments in mandibular weight,length, height and area (index of mandibular size) were negatively affected by the G diets, aswas the posterior part of the bone (posterior to molar III). The cross-sectional geometry ofthe mandible (cross-sectional area and rectangular moment of inertia) as well as itsstructural properties (yielding load, fracture load, and stiffness) were also severely affectedby the G diets. However, material properties (Young\u2019s modulus and maximum elastic stress)and calcium concentration in ashes and the degree of mineralisation were unaffected.Conclusions: The differences in strength and stiffness between treated and control ratsseemed to be the result of an induced loss of gain in bone growth and mass, in the absence ofchanges in the quality of the bone mineralised material.","palabras_clave":"MANDIBLE|GROWTH|WHEAT GLUTEN|BIOMECHANICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2639,"idioma_id":5,"titulo":"Propuesta metodológica de una guía para la clasificación de artefactos líticios históricos","resumen":"En este trabajo, se presenta una propuesta de guía para el análisis de artefactos líticos históricos. La misma surgió como una necesidad para abordar el estudio de este tipo de material de contextos históricos modernos ya que, por lo general, el análisis de los líticos arqueológicos se ha enfocado en contextos prehistóricos, dejando prácticamente de lado el estudio de restos líticos modernos.El interés en esta problemática comenzó cuando en una excavación en área urbana se halló gran cantidad de rocas graníticas y hubo que desarrollarse una metodología particular para abordar su análisis, ya que nuestra formación en el análisis lítico centrada en el estudio de artefactos prehistóricos no era suficiente. La misma había resultado operativa en otros contextos históricos, pero cuando se recuperaron 12 toneladas de rocas en el interior de un barco mercante hallado en Puerto Madero, Ciudad de Buenos Aires, decidimos ampliar, corregir y sobre todo clarificar la guía de análisis para que también otros investigadores pudieran realizar una tarea semejante.  En suma, la intención de este trabajo es proponer una guía metodológica para el análisis de instrumentos líticos históricos. En ésta se presta atención al artefacto, ecofacto y material a granel, como unidades de análisis de relevancia a escala local, regional e interregional.","palabras_clave":"Artefactos líticos históricos|Metodología de análisis|Contextos Urbanos|Modernidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2640,"idioma_id":5,"titulo":"Objetivo y Estado de Avance de Proyecto de Investigación CONICET. Beca de Doctorado.","resumen":"    Objetivo.  Estudiar el Error de Tipo I&nbsp; y la  potencia de las pruebas de Breslow-Day y de reglas que las combinan con el  procedimiento estándar de Mantel-Haenszel aplicadas a la detección del  funcionamiento diferencial del ítem (Differential Item Functioning, DIF) y  evaluar su desempeño comparando con otros métodos. Delimitar conceptual y  operacionalmente el constructo Razonamiento Analógico, administrar una escala  de Analogías Figurales (AF), modelizarla con los componentes de la Teoría Clásica de  Tests (TCT) y de la Teoría  de Respuesta al Item (TRI) y aplicar los resultados de la simulación a dicha  escala.    Estado de  avance. Se especificaron las propiedades psicométricas de las dos  versiones de la Prueba  desde la TCT y la TRI. En términos globales, las correlaciones ítem-total corregidas r y los parámetros de discriminación a aumentaron a la par en 9 de los 15  ítems modificados. En cuanto al resto de estos reactivos, dos ítems poseyeron  niveles de r y a estables a través de las dos versiones, en otro ítem los r y a  redujeron su valor y otros tres ítems tuvieron datos de discriminación  contradictorios. El b se redujo en la  amplia mayoría. La discriminación media de los ítems no modificados mejoró  significativamente al 5%, lo que se comprobó tanto al comparar las r medias de las dos versiones  (.46 vs. .50. t(40) =  -2.06; p = .046. TE = 0.64) como los parámetros de discriminación a medios&nbsp;(0.94 vs. 1.23. t(40) = -3.09; p = .004. TE =  0.95).    Se  encontraron diferencias estadísticamente significativas que favorecen a los  varones en todos los estudios efectuados, con valores de probabilidad menores  al 0.1%. En dos estudios distintos, los estudiantes de Arquitectura, que  cursaban el tercer año sin contar el CBC o algún año posterior, mostraron  diferencias significativas comparados con otros grupos pertenecientes tanto a  la segunda como a la primera muestra. Se encontró una interacción significativa  utilizando ANOVA bifactorial (F(1,1597) = 4.04; p =  .04), revelando que los estudiantes de Psicología  varones se desempeñaron mejor que los estudiantes del mismo género de  Arquitectura, Diseño y otras artes, no sucediendo lo mismo entre los dos grupos  de mujeres. Esto se corroboró además comparando ambos pares de grupos con t de Student (t(626) = -2.43; p = .02 y t(971) = 0.82; p = .41  respectivamente).    Se  completaron los estudios del Funcionamiento Diferencial del Ítem (Differential  Item Functioning, DIF). Se eliminó el ítem 9 de la segunda muestra por mostrar  DIF. También se eliminó el ítem 5, el cual poseía un número de atributos  desfavorables tales como a &lt; 0.65  y r &lt; .35, y finalmente el ítem 11  por no ajustar al Modelo de Tres Parámetros en ambas muestras. Por lo tanto, la Prueba definitiva contiene  33 reactivos.    Se  continuará con la construcción de ítems de Analogía Figural sobre la base del  Diseño de Combinación de Alternativas (Blum et al., 2013; Blum et al., 2012), y  se estudiará en ellos el parámetro de dificultad desde la TRI.  ","palabras_clave":"Razonamiento Analógico|Teoría de Respuesta al Ítem|Funcionamiento Diferencial del Ítem|Simulación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2641,"idioma_id":5,"titulo":"Informe San Luis 2011 \/ Memoria Federal","resumen":"El año 2012 fue el primer año de gestión al frente del Ejecutivo del Gobernador Claudio Poggi, luego de las sucesivas reelecciones de los hermanos Rodríguez Saá desde el advenimiento de la democracia. Dominada por los contrastes, presentes en una prolija administración de los recursos, una sostenida obra pública, el mantenimiento del empleo público local sin aumentos significativos, una legislatura sin sorpresas, el Informe concluye que la alternancia se ha presentado. Independientemente de la sucesión partidaria y de la contundente continuidad de las políticas precedentes, habrá que poner la mirada en un análisis global y el comportamiento electoral de 2013 y 2015.   Los principales tópicos desarrollados son los siguientes: Políticas Públicas Provinciales (Turismo, Deporte, Viviendas, Salud, Educación, Entrega de Computadoras, Inversión educativa); el Poder Judicial; Poder Legislativo y Municipio de la Capital. Luego se dedica especialmente a los denominados Casos relevantes de 2012: Fábricas recuperadas (Cooperativa de Trabajo INDIEL Limitada, Fábrica Textil Circus y La Negra); Promoción Industrial y la posición de la CSJN; judicialización de la Ley de Medios provincial.","palabras_clave":"DEMOCRACIA|ALTERNANCIA|POLÍTICAS|CASOS|TRABAJADORES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2643,"idioma_id":5,"titulo":"Categorización del estado de conservación de las lagartijas  y anfisbenas de la República Argentina","resumen":"Luego de la elaboración de la primera lista roja de la herpetofauna de la República Argentina,realizada en el año 2000, son numerosos los cambios y estudios efectuados en los diferentesgrupos de saurios de la Argentina. Si bien hay avances realizados en todas las ramas de labiología relacionadas a las lagartijas, los progresos taxonómicos y ecológicos son los más evidentes.Debido a estos progresos, y a la implementación de sustanciales modificaciones conrespecto a la metodología que se utilizara en el año 2000, un grupo de veintisiete especialistasde diferentes instituciones académicas de la Argentina aportaron información biológica, ecológica,geográfica y taxonómica en un taller que permitió reevaluar el estado de conservaciónde las 256 especies de lagartijas y anfisbenas de la Argentina. Los resultados obtenidos indicanque setenta y ocho especies se encuentran incluidas en la lista roja (una En Peligro, nueveAmenazadas y 68 Vulnerables), 31 Insuficientemente Conocidas y 147 No Amenazadas. Conrespecto a la categorización anterior de la AHA, se agregaron 94 especies, de las cuales 87 sonnuevos taxa, cuatro revalidadas, y otras tres especies fueron incorporadas a la fauna argentina.Asimismo cinco especies fueron extraídas del listado de la fauna de la República Argentina.En comparación con los resultados obtenidas en la categorización del año 2000, observamosque el número de especies Amenazadas se incrementó de cinco a nueve especies y de siete a68 especies como Vulnerable, incluyendo a los géneros Phymaturus y Anisolepis. Asimismo, secategorizó como Insuficientemente Conocida a 31 especies contra 108 del año 2000.Estos resultados son en parte debido al incremento en el conocimiento sistemático,biológico, ecológico y biogeográficos de las lagartijas y anfisbenas de la Argentina, porel cambio radical de la metodología utilizada y también por los efectos de la presiónantrópica sobre las especies y\/o sus habitats.","palabras_clave":"Conservacion|Herpetologia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2644,"idioma_id":5,"titulo":"RESONANCE OF HEAT TRANSFER IN A ONE DIMENSIONAL CHAIN WITH TUNEABLE COUPLING.","resumen":"Pese a que el problema del transporte de calor tiene cientos de años de antigüedad desde que Fourier dio a conocersu tan famosa ley de conducción, aún se desconocen las condiciones necesarias para que ésta se cumpla en sistemasde baja dimensión. Es por ello, además de por su interés práctico en el desarrollo tecnológico, que el control deltransporte de energía en sistemas nanométricos de baja dimensión es un área de estudio que ha cobrado un graninterés en los últimos años. En este trabajo estudiamos la posibilidad de controlar el transporte de energía a lo largode una cadena no-lineal unidimensional que consiste en dos segmentos con diferentes estructuras conectadosmediante un acoplamiento modulado temporalmente. Los extremos de cada conductor están acoplados a reservoriostérmicos también modulados en el tiempo. Analizamos la existencia de rectificación térmica y de comportamientosresonantes de la corriente de energía, como función de las frecuencias características del sistema. Discutimos elmecanismo físico subyacente.","palabras_clave":"Fenómenos de Transporte"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2647,"idioma_id":4,"titulo":"Measurement of the Proton-Air Cross Section at sqrt(s) 57 TeV with the Pierre Auger Observatory","resumen":"We report a measurement of the proton-air cross-section for particleproduction at the center-of-mass energy per nucleon of 57 TeV. This is derivedfrom the distribution of the depths of shower maxima observed with the PierreAuger Observatory: systematic uncertainties are studied in detail. Analysingthe tail of the distribution of the shower maxima, a proton-air cross-sectionof $[505\\pm22(stat)^{+28}_{-36}(sys)]$ mb is found.","palabras_clave":"Cosmic Rays|Cross Section"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2648,"idioma_id":4,"titulo":"Interstellar H3+ and HCS+ Ions Produced in the Dissociative Photoionization Process of CH3C(O)SCH3 in the Proximity of the Sulfur 2p, Carbon 1s, and Oxygen 1s Edges","resumen":"In this work we present a study of the dissociative photoionization of S-methyl thioacetate [CH3C(O)SCH3] by using multicoincidence time-of-flight mass spectrometry and synchrotron radiation in the S 2p, C 1s, and O 1s edges. Total and partial ion yield spectra together with photoelectron&#8722;photoion coincidence (PEPICO) and photoelectron&#8722;photoion&#8722;photoion coincidence (PEPIPICO) spectra were measured. Fragmentation patterns deduced from PEPICO and PEPIPICO spectra at the various excitation energies show a moderate site-specific fragmentation. The dissociation dynamic for the main ion-pair production is discussed. Two-, three-, and four-body dissociation channels have been observed in the PEPIPICO spectra, and the dissociation mechanisms are proposed. The interstellar HCS+ and H3+ ions can be observed during the synchrotron experiments reported in the present work.","palabras_clave":"SYNCHROTRON RADIATION|INNER SHELL ELECTRONS|PHOTOIONIZATION|SULFENYL CARBONYL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2649,"idioma_id":4,"titulo":"New locations and parasitological findings for the invasive shrimp Palaemon macrodactylus in temperate southwestern Atlantic coastal waters","resumen":"This paper presents new records that considerably expand the geographical range of the invasive shrimp Palaemon macrodactylus in Argentina to include new estuarine areas on the Argentine south Atlantic coast: Bahía Samborombón, and the Bahía Blanca and Río Negro estuaries. The latter 2 locations are the southernmost reports for this species. The epibiotic barnacle Balanus amphitrite and a microphallid metacercaria Odhneria sp. are reported for the first time in P. macrodactylus. The prevalence of white spot syndrome virus (WSSV) was 10% in the Bahía Blanca estuary. Our results strongly suggest that WSSV is spreading in crustacean populations in the Argentine Sea and that P. macrodactylus plays a role in the ecology of parasite infections in this environment.","palabras_clave":"PALAEMON|PARASITES|WSSV|INVASIVE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2650,"idioma_id":4,"titulo":"Low extracellular pH stimulates the production of IL-1 beta by human monocytes.","resumen":"The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that extracellular acidosis (pH 6.5) selectively stimulates the production and the secretion of IL-1beta by human monocytes without affecting the production of TNF-alpha, IL-6 and the expression of CD40, CD80, CD86, and HLA-DR. Stimulation of IL-1beta production by pH 6.5-treated monocytes was shown to be dependent on caspase-1 activity, and it was also observed using peripheral blood mononuclear cells instead of isolated monocytes. Contrasting with the results in monocytes, we found that pH 6.5 did not stimulate any production of IL-1beta by macrophages. Changes in intracellular pH seem to be involved in the stimulation of IL-1beta production. In fact, monocytes cultured at pH 6.5 undergo a fall in the values of intracellular pH while the inhibitor of the Na+\/H+ exchanger, 5-(N-ethyl-N-isopropyl)amiloride induced both, a decrease in the values of intracellular pH and the stimulation of IL-1beta production. Real time quantitative PCR assays indicated that monocytes cultured either at pH 6.5 or in the presence of 5-(N-ethyl-N-isopropyl)amiloride expressed higher levels of pro-IL-1beta mRNA suggesting that low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor.","palabras_clave":"ACIDOSIS|HUMAN MONOCYTES|pH|IL-1BETA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2651,"idioma_id":4,"titulo":"Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-&#954;B p65 subunit phosphorylation","resumen":"Thyroid peroxidase (TPO), a tissue-specific enzyme expressed in differentiated thyroid follicular cells, is a major antigen that has been linked to autoimmune thyroid disease. We have previously reported the functional expression of the lipopolysaccharide (LPS) receptor Toll-like receptor 4 on thyroid follicular cells. Here we investigated the effect of LPS in TPO expression and analyzed the mechanisms involved. We found a dose-dependent enhancement of TSH-induced TPO expression in response to LPS stimulation. EMSAs demonstrated that LPS treatment increased thyroid transcription factor-1 and -2 binding to the B and Z regions of TPO promoter, respectively. Moreover, LPS increased TSH-stimulated TPO promoter activity. Using bioinformatic analysis, we identified a conserved binding site for transcription nuclear factor-kB (NF-kB) in the TPO promoter. Chemical inhibition of NF-kB signaling and site-directed mutagenesis of the identified kB-cis-acting element abolished LPS stimulation. Furthermore, chromatin immunoprecipitation assays confirmed that TPO constitutes a novel NF-kB p65 subunit target gene in response to LPS. Additionally, our results indicate that p65 phosphorylation of serine 536 constitutes an essential step in the p65-dependent, LPS-induced transcriptional expression of TPO. In conclusion, here we demonstrated that LPS increases TPO expression, suggesting a novel mechanism involved in the regulation of a major thyroid autoantigen. Our results provide new insights into the potential effects of infectious processes on thyroid homeostasis.","palabras_clave":"THYROID PEROXIDASE|LIPOPOLYSACCHARIDE|NF-kB|p65"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2652,"idioma_id":4,"titulo":"Influence of filler alignment in the mechanical and electrical properties of carbon nanotubes\/epoxy nanocomposites. Physica","resumen":"In this work, we report the mechanical and electrical properties of carbon nanotubes\/epoxy composites prepared with aligned and randomly oriented nanotubes as filler. The samples are disks of 30 mm in diameter and 3 mm in thickness. To obtain the carbon nanotubes alignment, an external electric field (250 VAC; 50 Hz) was applied through the thickness of the sample during all the cure process. The AC electrical current was measured, during the cure, as a strategy to determine the optimum time in which the alignment reaches the maximum value. DC conductivity measured after the cure shows a percolation threshold in the filler content one order of magnitude smaller for composites with aligned nanotubes than for composites with randomly oriented filler (from 0.06 to 0.5 wt%). In the percolation threshold, the achieved conductivity was 1.4×10&#8722;5 Sm&#8722;1. In both cases, aligned and randomly distributed carbon nanotube composites, the wear resistance increases with the addition of the filler while the Rockwell hardness decreases independently of the nanotubes alignment.","palabras_clave":"epoxy nanocomposites|electrical properties|mechanical properties|carbon nanotubes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2653,"idioma_id":4,"titulo":"Valeriana officinales dry plant extract for direct compression: Preparation and characterization","resumen":"Valeriana officinalis L. (Valerianaceae) is one of the most used plants for the treatment of anxiety and insomnia. Usually dry plant extracts, including  V. officinalis, are hygroscopic materials with poor physico-mechanical properties to be directly compressed. A V. officinalis dry extract, with moderate hygroscocity and suitable for direct compression, was obtained by using a simple and economical technique. The V. officinalis fluid extract was oven dried with colloidal silicon dioxide as drying adjuvant. The addition of colloidal silicon dioxide gave a dry plant extract with good physico-mechanical properties for direct compression and with lower hygroscopicity than the dry extract without carrier. The dry plant extract glass transition temperature was considerable above room temperature (about 72º C). The colloidal silicon dioxide also produced an antiplasticizing effect, improving the powder physically stability. The pharmaceutical performance of the prepared V. officinalis dry extract was studied through the design of tablets. The manufactured tablets showed good compactability, friability, hardness and disintegration time. Those containing a disintegrant (Avicel PH 101) exhibited  the best pharmaceutical performance, being the lowest disintegration time of around 40 seconds.","palabras_clave":"Valeriana officinalis|dry plant extract|direct compression|glass transition temperature"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2654,"idioma_id":4,"titulo":"RESPONSE OF BIOMARKERS IN AMPHIBIAN LARVAE TO IN SITU EXPOSURES IN A FRUIT PRODUCING REGION AT NORTH PATAGONIA, ARGENTINA","resumen":"We evaluated biomarker responses in caged larvae of the amphibian Rhinella arenarum in water channels during fruit production season, and compared them with those elicited by a transient exposure to azinphos methyl (AzM) (0.02-2 mg\/L; 4 h), the main pesticide applied in the Alto Valle region, Patagonia Argentina, taking into account the maximum environmental concentration detected in superficial water (22.5 µg\/L). The traditional biomarkers of organophosphate exposure, acetylcholinesterase (AChE) and carboxylesterase (CE), were inhibited in tadpoles after one week of exposure in channels potentially receiving pesticide drift, while the antioxidant glutathione (GSH) and the detoxifying activity of GSH-S-transferase (GST) were induced. In a two-week monitoring study, AChE activity was induced and CE activity showed a temporary inhibition in larvae exposed at the agricultural site, and CE showed an inhibition followed by the return to control values suggesting an exposure episode followed by a recovery process. GSH levels were first depleted and then surpassed control levels while GST activity was continuously induced. These responses were mimicked in the laboratory by 2 mg\/L AzM-pulse exposure and recovery, which notably exceeds the expected environmental concentrations. The results draw attention to the complexity of the responses under pesticide exposure, strongly depending on exposure time-concentration and recovery periods among other possible factors, and support the necessity of the integrated use of biomarkers to assess exposure episodes in agricultural areas.","palabras_clave":"ACETYLCHOLINESTERASE|CARBOXYLESTERASE|GLUTATHIONE|GLUTATHIONE S-TRANSFERASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2655,"idioma_id":4,"titulo":"Renormalization. The observable-state model, II","resumen":"The purpose of this work is to rewrite the generating functional of &#981;4 theory for the n=0 and n=4 correlation functions as the inner product of a state with an observable, as we did in a previous work, for the two-points correlation function. The observables are defined through the external sources and the states are defined through the correlation function itself. In this sense, the divergences of Quantum Field Theory (QFT) appear in the reduced state by taking the partial trace of the state with respect to the internal vertices that appear in the perturbation expansion. From this viewpoint, the renormalization can be substituted by applying a projector on the internal quantum state. The advantage of this new insight is that we can obtain finite contributions to the correlation functions without introducing counterterms in the Lagrangian or by manipulating complex divergent quantities.","palabras_clave":"Renormalization|Observables|States|Projection"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2656,"idioma_id":4,"titulo":"Evidence for an adaptation in ROS scavenging systems in human peritubular testicular cells from infertility patients","resumen":"Fibrosis, increased amounts of immune cells and expression of COX-2 in the testes of infertility patients provide circumstantial evidence for a specific testicular milieu, in which reactive oxygen species (ROS) could be increased. If ROS level increase and\/or ROS scavengers decrease, the resulting testicular oxidative stress may contribute to human male infertility. Primary peritubular cells of the human testis, from men with normal spermatogenesis (HTPCs) and infertile patients (HTPC-Fs), previously allowed us to identify an end product of COX-2 action, a prostaglandin derivative (15dPGJ2), which acts via ROS to alter the phenotype of peritubular cells, at least in vitro. Using testicular biopsies we now found 15dPGJ2 in patients and hence we started exploring the ROS scavenger systems of the human testis. This system includes catalase, DJ-1, peroxiredoxin 1, SOD 1 and 2, glutathione-S-transferase and HMOX-1, which were identified by RT-PCR\/sequencing in HTPCs and HTPC-Fs and whole testes. Catalase, DJ-1, peroxiredoxin 1 and SOD 2 were also detected by Western blots and in part by immunohistochemistry in testicular samples. Western blots of cultured cells further revealed that catalase levels, but not peroxiredoxin 1, SOD 2 or DJ-1 levels, are significantly higher in HTPC-Fs than in HTPCs. This particular difference is correlated with the improved ability of HTPC-Fs to handle ROS, which became evident when cells were exposed to 100 &#956;m H(2)O(2). H(2)O(2) induced stronger responses in HTPCs than in HTPC-Fs, which correlates with the lower level of the H(2)O(2)-degrading defence enzyme catalase in HTPCs. The results provide evidence for an adaptation to elevated ROS levels, which must have occurred in vivo and which persist in vitro in HTPC-Fs. Thus, in infertile men with impaired spermatogenesis elevated ROS levels likely exist, at least in the tubular wall.","palabras_clave":"ROS SYSTEM|HUMAN TESTICULAR|CYCLOOXYGENASE SYSTEM|PROSTAGLANDIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2657,"idioma_id":5,"titulo":"Actividad antibacteriana y ensayos de toxicidad aguda y  subaguda de Polygonum hidropiperoides","resumen":"Se evaluó la presencia de toxicidad y se determinó la concentración inhibitorio mínima de extractos obtenidos a partir de Polygonum hidropiperoides sobre cepas bacterianas de colección, Staphylococcus aureus y Staphylococcus epidermis y de campo. Streptococcus equi, Proteus spp y Escherichia coli. Para estudiar la actividad antimicrobiana con el método de dilución en agar se utilizó el extracto metanólico. Los ensayos de toxicidad aguda y subaguda se llevaron a cabo en ratones utilizando una dosis única de 5000 mg\/kg y una dosis diaria durante 14 días de 1250 mg\/Kg de extracto hidroalcoholico, respectivamente. La concentración inhibitoria mínima de extracto metanólico de Polygonum hidropiperoides fue de 0,18 mg\/ml para Streptococcus equi, Proteus spp, Staplylococcus aureus, Staplylococcus epidermidis y de 0,37 mg\/ml para Echerichia coli. Los ensayos de toxicidad no evidenciaron cambios funcionales u orgánicos en los animales de experimentación. Los resultados obtenidos dan sustento&nbsp; a la investigación de la actividad antimicrobiana in vivo para determinar el valor fitoterapéutico de la especie.","palabras_clave":"EXTRACTOS VEGETALES|CONCENTRACION INHIBITORIA MINIMA|TOXICIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2710,"idioma_id":5,"titulo":"Resultados productivos y económicos del cultivo de maíz en Tucumán, campaña 2012\/13 vs 2011\/12.","resumen":"Análisis de indicadores económicos, gastos y márgenes brutos del cultivo de soja en Tucumán","palabras_clave":"ESTADÍSTICAS|MARGEN|BRUTO|SOJA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2712,"idioma_id":5,"titulo":"El concepto de solidadridad en Enrique Dussel como resistencia a las prácticas hegemónicas","resumen":"EL CONCEPTO DE SOLIDARIDAD EN ENRIQUE DUSSEL COMO RESISTENCIA A LAS PRÁCTICAS HEGEMÓNICAS  Gloria Silvana ELÍAS    Resumen    El siguiente estudio trata sobre la fi losofía de Enrique Dussel. Este pensador, mediante la lectura de Levinas, propone superar la noción moderna de fraternidad desde una solidaridad con los enemigos del sistema. La categoría de solidaridad es la que guía este escrito en su afán de promover una política auténticamente alterativa que se conmueve ante el sufrimiento del enemigo radical, y se mueve hacia él en busca de la liberación mutua.","palabras_clave":"AMISTAD|POLITICA|FRATERNIDAD|SOLIDARIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2719,"idioma_id":4,"titulo":"Search for pair-produced massive coloured scalars in four-jet final states with the ATLAS detector in proton-proton collisions at $\\sqrt{s}=7$ TeV","resumen":"A search for pair-produced massive coloured scalar particles decaying to a four-jet final state is performed by the ATLAS experiment at the LHC in proton\u2013proton collisions at s&#8730;=7 TeV . The analysed data sample corresponds to an integrated luminosity of 4.6 fb&#8722;1. No deviation from the Standard Model is observed in the invariant mass spectrum of the two-jet pairs. A limit on the scalar gluon pair production cross section of 70 pb (10 pb) is obtained at the 95 % confidence level for a scalar gluon mass of 150 GeV (350 GeV). Interpreting these results as mass limits on scalar gluons, masses ranging from 150 GeV to 287 GeV are excluded at the 95 % confidence level.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2721,"idioma_id":4,"titulo":"Contrasting functional trait syndromes underlay woody alien success in the same ecosystemaec_2428 1..9","resumen":"We performed a comprehensive comparative study of functional traits in coexisting alien and native  woody species in order to examine the strategies related to resource use and dispersion underlying alien success in  mountain Chaco woodlands of central Argentina. Our approach integrated seemingly contrasting pieces of evidence  in the region.We specifically assessed whether (i) the \u2018functional acquisitive trend\u2019 previously observed along a  broad environmental gradient accounts for woody alien naturalization when considering a single mesic ecosystem;  or (ii) more than one trait syndrome is important among alien species, which would be more in line with the  context-dependent nature of biological invasions at a local scale. Fifteen vegetative and regenerative traits were  measured on the most common 14 native and 11 alien woody species.We compared the attributes of (i) native and  alien species and (ii) between native species and two contrasting groups of alien species identified in the previous  analysis.The overall trait comparison (i) showed that, in terms of vegetative attributes, woody alien species tend to  be on average more acquisitive than native species. However, (ii) two contrasting syndromes were revealed among  alien species: a group of seven deciduous species with acquisitive attributes; and a group of four evergreen species  showing markedly more conservative attributes than the first group. The functional attributes of \u2018conservative  aliens\u2019 completely overlapped with the range observed for native species, except for an exclusive dispersal phenology  and a stronger tendency to clonal spread. Acquisitive aliens, in turn, proved to be beyond the range of attributes of  native species, at the acquisitive extreme, as they did in previous comparisons. Despite their importance, general  trends in plant functional attributes across regions and ecosystems can sometimes obscure trends at more local  scales that are nevertheless important for the understanding and management of particular systems. Our study  concurs with previous general trends when looking at the overall comparison between native and alien species, but  unveils contrasting functional strategies among alien species when examining their attributes more closely, even  within the same ecosystem.","palabras_clave":"woody invaders|plant functional traits|conservative species|acquisitive species"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2727,"idioma_id":4,"titulo":"Compressing arrays of classifiers using Volterra-Neural Network: application to face recognition (Indexed SCI IF2012 1.168).","resumen":"Model compression is required when large models are used, for example, for a classification task, but there are transmission, space, time or computing constraints that have to be fulfilled. Multilayer Perceptron (MLP) models have been traditionally used as classifiers. Depending on the problem, they may need a large number of parameters (neuron functions, weights and bias) to obtain an acceptable performance. This work proposes a technique to compress an array of MLPs, through the weights of a Volterra-Neural Network (Volterra-NN), maintaining its classification performance. It will be shown that several MLP topologies can be well-compressed into the first, second and third order (Volterra-NN) outputs. The obtained results show that these outputs can be used to build an array of (Volterra-NN) that needs significantly less parameters than the original array of MLPs, furthermore having the same high  accuracy. The Volterra-NN compression capabilities were tested for solving a face recognition problem. Experimental results are presented on two well-known face databases: ORL and FERET.","palabras_clave":"Model compression|Array of neural networks|Volterra Neural networks|Face recognition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2728,"idioma_id":4,"titulo":"Antioxidant and molecular chaperone defenses during estivation and arousal in the South American apple-snail Pomacea canaliculata","resumen":"The invasive Pomacea canaliculata estivates during periods of drought and should cope with harmful effects of reoxygenation during arousal. We studied thiobarbituric acid reactive substances (TBARS), enzymatic (superoxide dismutase, SOD and catalase, CAT) and non-enzymatic ontioxidants (uric acid and reduced glutathione), and heat shock protein expression (Hsc70, Hsp70 and Hsp90) in (1) active control snails, (2) snails after 45 days of estivation, and (3) aroused snails 20 min and (4) 24 h after water exposure, in midgut gland, kidney and foot. Both kidney and foot (but not the midgut gland) showed a TBARS increase during estivation and a decrease after arousal. Tissue SOD and CAT did not change in any experimental groups. Uric acid increased during estivation in all tissues, and it decreased after arousal in the kidney. Allantoin, the oxidation product of uric acid, remained constant in the midgut gland but it decreased in the kidney until 20 min after arousal; however, allantoin levels rose in both kidney and foot 24 h after arousal. Reduced glutathione decreased during estivation and arousal, in both midgut gland and kidney, and it remained constant in the foot. Hsc70 and Hsp70 kidney levels were stable during the activity-estivation cycle and Hsp90 expression decrease during estivation and recovers in the early arousal. In foot, the expression of Hsp70 and Hsp90 was high during activity and estivation periods and disminished after arousal. Results indicate that a panoply of antioxidant and molecular chaperone defenses may be involved during the estivation-arousal cycle in this freshwater gastropod.","palabras_clave":"gastropod|oxidative stress|oxyradical|uric acid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2729,"idioma_id":4,"titulo":"Circulation in Drake Passage revisited using new current time series and satellite altimetry: 1. The Yaghan Basin","resumen":"&nbsp;Time series of horizontal velocities   were obtained at four mooring sites across the Ona Basin, southern Drake   Passage, during 26&#8201;months (February 2006 to April 2008). The moorings   were located under the Jason satellite ground-track #104, allowing   precise comparisons with various other altimetry products. Velocities as   high as 0.5&#8201;m&#8201;s?1 at 500&#8201;m depth were observed during current pulses. Mean velocity amplitudes at 500&#8201;m reached 0.22&#8201;m&#8201;s?1 at 58.5°S and 0.15&#8201;m&#8201;s?1 at 60°S, but were smaller at 59°S and 60.5°S. Mean velocities at 2500&#8201;m depth varied between 0.05 and 0.10&#8201;m&#8201;s?1   and were westward on two of the moorings, suggesting recirculation in   the center of the basin. Mean velocities were consistent with a general   cyclonic circulation in the Ona Basin. The mean velocity vectors were   observed to rotate with depth, the sense of rotation depending upon   mooring sites. Standard deviation ellipses were close to circular except   on the continental slope (60.5°S) where they were stretched in the   direction of isobaths. The southernmost mooring was under sea ice in   winter, and velocity variations were reduced in amplitude during that   period. The horizontal velocities were highly coherent in the vertical.   Altimetrically derived surface geostrophic velocities compared well with   the in situ velocities and were used to investigate further the flow   over the West Scotia Ridge and in the center of the Ona Basin to the   East of the highest part of the Shackleton Ridge, which provides some   shelter from the eastward flowing Antarctic Circumpolar Current.","palabras_clave":"Drake Passage;  |   Antarctic Circumpolar Current;    | Ona Basin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2732,"idioma_id":4,"titulo":"Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuales reproductive derangements in nude female mice","resumen":"Congenitally athymic (nude) female mice show severe ovarian dysgenesis after puberty, whichseems to be consequential to a number of neuroendocrine derangements described in thesemutants. Thus, considerable evidence suggests that thymulin, a thymic peptide, may be involvedin thymus-pituitary communication. In order to clarify the relevance of thymulin for the maturationof the female reproductive system, we assessed at hypothalamic, pituitary, ovarian, and uterinelevel the preventive action of neonatal thymulin gene therapy (NTGT) on the changes that typicallyoccur after puberty in congenitally athymic female mice. We injected (im) an adenoviral vectorharboring a synthetic DNA sequence encoding a biologically active analog of thymulin, metFTS, innewborn nude mice (which are thymulin deficient) and killed the animals at 70?71 d of age. NTGTin the athymic mice restored the serum thymulin levels. Morphometric analysis revealed thatathymic nudes have reduced numbers of brain GnRH neurons and pituitary gonadotropic cells ascompared with heterozygous controls. NTGT prevented these changes and also rescued the prematureovarian failure phenotype typically observed in athymic nude mice (marked reduction inthe number of antral follicles and corpora lutea, increase in atretic follicles). Serum estrogen, butnot progesterone, levels were low in athymic nudes, a reduction that was partially prevented byNTGT. Little to no morphological changes were observed in the myometrium of female nudes. Thedelay in the age of vaginal opening that occurs in athymic nudes was significantly prevented byNTGT. Our results suggest that thymulin plays a relevant physiologic role in the thymus-hypothalamo-pituitary-gonadal axis. (Endocrinology 153: 0000?0000, 2012)(Endocrinology 153: 0000?0000, 2012)","palabras_clave":"NEONATAL GENE THERAPY|THYMULIN|OVARIAN DYSGENESIS|NUDE FEMALE MICE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2733,"idioma_id":4,"titulo":"Cut-off values of serum growth hormone (GH) in pharmacological stimulation tests (PhT) evaluated in short-statured children using a chemiluminescent immunometric assay (ICMA) calibrated with the International Recombinant Human GH Standard 98\/574","resumen":"Ver texto completo","palabras_clave":"GH|CUT-OFF|ICMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2734,"idioma_id":4,"titulo":"Potential zooplankton preys (Copepoda and Appendicularia) for Engraulis anchoita in relation to early larval and spawning distributions at the Patagonian frontal region (SW Atlantic Ocean)","resumen":"","palabras_clave":"southwestern atlantic ocean|Noth Patagonian frontal system|copepods|appenducularians"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2735,"idioma_id":4,"titulo":"Unexpected Failures to Control Chagas Disease Vectors With Pyrethroid Spraying in Northern Argentina","resumen":"Effectiveness of the elimination efforts against Triatoma infestans in South America through residual application of pyrethroid insecticides has been highly variable in the Gran Chaco region. We investigated apparent vector control failures after a standard community-wide spraying with deltamethrin SC in a rural area of northeastern Argentina encompassing 353 houses. Insecticidespraying reduced house infestation rate less than expected: from 49.5% at baseline to 12.3 and 6.7% at 4 and 8mo postspraying, respectively. Persistent infestations were detected in 28.4% of houses, and numerous colonies with late-stage bugs were recorded after the interventions. Laboratory bioassays showed reduced susceptibility to pyrethroids in the local bug populations. Eleven of 14 bug populations showed reduced mortality in diagnostic dose assays (range, 35% to 97%) whereas the remainder had 100% mortality. A fully enclosed residual bug population in a large chicken coop survived four pyrethroid sprays, including two double-dose applications, and was Þnally suppressed with malathion. The estimated resistance ratio of this bug population was 7.17 (range, 4.47-11.50). Our field data combined with laboratory bioassays and a residual foci experiment demonstrate that the initial failure to suppress T. infestans was mainly because of the unexpected occurrence of reduced susceptibility to deltamethrin in an area last treated with pyrethroid insecticides 12 yr earlier. Our results underline the need for close monitoring of the impact of insecticide spraying to provide early warning of possible problems because of enhanced resistance or tolerance and determine appropriate responses.","palabras_clave":"Triatoma infestans|Chagas disease|vector control|reinfestation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2736,"idioma_id":4,"titulo":"First Report of Foliar Infection of Cabbage by Phytophthora drechsleri in Argentina","resumen":"Cabbage (Brassica oleracea var. capitata L.) is a popular crop grown along the northeast horticultural belt of Buenos Aires Province, Argentina. In the summer of 2010, fields in this region remained flooded for long periods due to frequent and intense precipitation (560 mm from January to March). Commercial cabbage crops in the cities of Luján and General Rodríguez developed patches of diseased plants that were stunted and wilted. Affected plants had necrotic areas in the crowns and roots. Symptoms expanded to the upper stems, leaving vascular tissues exposed. During April 2010, samples from 2 fields were brought to the laboratory where the stems were washed thoroughly and disinfected with a 1% bleach solution for 2 minutes. Small pieces (5 mm in diameter) were removed from the lesion edge, plated on V8 agar (V8A) plates, and incubated at 24°C in the dark for 5 days. Four isolates were transferred to V8A using hyphal tips. Morphological studies were performed on the V8A cultures as well as plates flooded with tap water. Sporangia were obpyriform, nonpapillate, persistent, and variable in size, averaging 44 × 28 &#956;m. Each isolate belonged to the A1 mating type when paired with P. capsici tester isolates, CBS 370.72 and CBS 111.334 (Fungal Biodiversity Centre, CBS, Utrecht, the Netherlands). The isolates produced amphigynous antheridia, and chlamydospores were present but scarce. Maximum temperatures for growth (37°C) were also performed. Edited sequences of the internal transcribed spacer (ITS) region of the rDNA (GenBank Accession Nos. JQ653300, JQ653301, JQ653302, and JQ653303) were compared with Phytophthora sequences available in GenBank using the BLASTN search utility (1) and aligned to the data set of Cooke et al. (2). Sequences of the four isolates (strains 2: R-cai-cuello-col-3, 3: R-cai-cuello-col-18, 4: R-AN-col-1A and 5: R-AN-col-1B) matched 100% with GenBank sequences of P. drechsleri (100% coverage, 100% identity and no gaps). Based on these results, the four Argentinian cabbage isolates were identified as P. drechsleri (3). Pathogenicity tests were completed using three detached heads of mature cabbage plants (B. oleracea var. capitata) for each isolate. A 5-mm colonized mycelial plug of the appropriate isolate was placed on the main vein of the outermost leaves. For the control treatments, three heads were inoculated with non-colonized V8A plugs. The inoculated and control heads of cabbage were incubated in plastic boxes wrapped in black nylon bags at 24°C for 4 days. Broccoli (B. oleracea var. italica) and cauliflower (B. oleracea var. botrytis) were also tested following the same procedure. All heads of cabbage, broccoli, and cauliflower developed necrotic lesions 2 to 4 cm in diameter and a dark grey color. Control heads of each plant remained green. P. dreschleri was consistently reisolated as described above from the inoculated heads, but not from the control heads. To our knowledge, this is the first report of cabbage as a host for P. dreschleri in Argentina. Frezzi (4) reported this species as a pathogen of Chrysanthemum cinerariefolium, Celosia plumosa, Schinus molle, and Solanum lycopersicum in Argentina in 1950.","palabras_clave":"Cabbage, Phytophthora drechsleri"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2737,"idioma_id":4,"titulo":"Mass transfer kinetics and regressional-desirability optimisation during osmotic dehydration of pumpkin, kiwi and pear","resumen":"Mass transfer kinetics and optimisation of osmotic dehydration (OD) of fruits and vegetables with diverse structures were studied. Different concentrations of sucrose (20?60 ºBrix) and process times (0?24 h) were used. Magee?s model was appropriate for predicting water loss (WL), while Azuara?s model fitted well solids gain (SG) data and represented more accurately the evolution of the complete process close to equilibrium. Polynomial equations for each kinetic variable [WL, SG and weight reduction (WR) ? for pumpkin, kiwi and pear] using multiple linear regression were fitted for a selected range of experimental data (30?240 min, 20?60 ºBrix). A complete solution algorithm for desirability function was coded in Matlab® 7.2 (Mathworks, Natick, MA, USA) with the aim to optimise osmotic dehydration process in terms of WL, SG and WR; optimal conditions were found for each fruit. Besides, an optimal common zone was identified for OD corresponding to process time from 114 to 240 min and sucrose concentration from 54 to 60 ºBrix.","palabras_clave":"BUTTERNUT PUMPKIN|EMPIRICAL MODELLING|KIWI|OPTIMISATION|OSMOTIC DEHYDRATION|PEAR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2738,"idioma_id":4,"titulo":"Selective blockade of trypanosomatid protein synthesis by a recombinant antibody anti-Trypanosoma cruzi P2beta protein","resumen":"The ribosomal P proteins are located on the stalk of the ribosomal large   subunit and play a critical role during the elongation step of protein   synthesis. The single chain recombinant antibody C5 (scFv C5) directed against the C-terminal region of the Trypanosoma cruzi P2beta protein (TcP2beta) recognizes the conserved C-terminal end of all T. cruzi ribosomal P proteins. Although this region is highly conserved among different species, surface plasmon resonance analysis showed that the scFv C5 possesses very low affinity for the corresponding mammalian   epitope, despite having only one single amino-acid change. Crystallographic analysis, in silico modelization and NMR assays support   the analysis, increasing our understanding on the structural basis of   epitope specificity. In vitro protein synthesis experiments showed that scFv C5 was able to specifically block translation by T. cruzi and Crithidia fasciculata ribosomes, but virtually had no effect on Rattus norvegicus ribosomes. Therefore, we used the scFv C5 coding sequence to make inducible intrabodies in Trypanosoma brucei. Transgenic parasites showed a strong decrease in their growth rate after induction. These results strengthen the importance of the P protein C terminal regions for ribosomal translation activity and suggest that trypanosomatid ribosomal P proteins could be a possible target for selective   therapeutic agents that could be derived from structural analysis of the scFv C5 antibody paratope.","palabras_clave":"TRYPANOSOMA CRUZI|RIBOSOMAL P PROTEINS|RECOMBINANT ANTIBODY|TRANSLATION INHIBITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2739,"idioma_id":4,"titulo":"Comparative study of variational chaos indicators and ODEs  numerical integrators (Review)","resumen":"The reader can find in the literature a lot of different techniques to study the dynamics of a given system and also, many suitable numerical integrators to compute them. Notwithstanding the recent work of [Maffione et al., 2011b] for mappings, a detailed comparison among the widespread indicators of chaos in a general system is still lacking. Such a comparison could lead to select the most efficient algorithms given a certain dynamical problem. Furthermore, in order to choose the appropriate numerical integrators to compute them, more comparative studies among numerical integrators are also needed.     This work deals with both problems. We first extend the work of [Maffione et al., 2011b] for  mappings to the 2D [Hénon & Heiles, 1964] potential, and compare several variational indicators of chaos: the Lyapunov Indicator (LI); the Mean Exponential Growth Factor of Nearby Orbits (MEGNO); the Smaller Alignment Index (SALI) and its generalized version, the Generalized Alignment Index (GALI); the Fast Lyapunov Indicator (FLI) and its variant, the Orthogonal  Fast Lyapunov Indicator (OFLI); the Spectral Distance (D) and the Dynamical Spectra of Stretching Numbers (SSNs). We also include in the record the Relative Lyapunov Indicator (RLI), which is not a variational indicator as the others. Then, we test a numerical technique to integrate Ordinary Differential Equations (ODEs) based on the Taylor method implemented by [Jorba & Zou, 2005] (called taylor), and we compare its performance with other two well-known efficient integrators: the [Prince & Dormand, 1981] implementation of a Runge-Kutta of order 7\/8 (DOPRI8) and a Bulirsch-Stöer implementation. These tests are run under two very different systems from the complexity of their equations point of view: a triaxial galactic potential model and a perturbed 3D quartic oscillator.    We first show that a combination of the FLI\/OFLI, the MEGNO and the GALI2N succeeds in describing in detail most of the dynamical characteristics of a general Hamiltonian system. In the second part, we show that the precision of taylor is better than that of the other integrators tested, but it is not well suited to integrate systems of equations which include the variational ones, like in the computing of almost all the preceeding indicators of chaos. The result which induces us to draw this conclusion is that the computing times spent by taylor are far greater than the times consumed by the DOPRI8 and the Bulirsch-Stöer integrators in such cases. On the other hand, the package is very efficient when we only need to integrate the equations of motion (both in precision and speed), for instance to study the chaotic diffusion. We also notice that taylor attains a greater precision on the coordinates than either the DOPRI8 or the Bulirsch-Stöer.","palabras_clave":"CHAOS INDICATORS|NUMERICAL INTEGRATORS|VARIATIONAL EQUATIONS|HAMILTONIAN SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2740,"idioma_id":4,"titulo":"- Synthesis of macroporous polymers with radical scavenging properties by immobilization of polyphenolic compounds.","resumen":"Solid phase radical scavengers have been prepared by the immobilization of antioxidant (AOX) compounds  on macroporous polymers. Poly(glycidylmethacrylate-co-trimethylolpropane trimethacrylate)  [poly(GMA TRIM)] and poly(N-acryloyl-tris(hydroxymethyl)aminomethane-co-glycidylmethacrylateco-  N,N0-methylenebisacrylamide) [poly(NAT GMA BIS)] were prepared by free radical polymerization  using a mixture of dimethylsulfoxide (DMSO)-poly(ethyleneglycol) 6000 (PEG 6000) as a porogenic solvent.  The polymers were aminated with ethylenediamine (EDA) and the linkage of the polyphenolic compounds  (gallic and caffeic acids) was carried out by two different approaches: through N,N0-  dicyclohexylcarbodiimide\/4-dimethylaminepyridine (DCC\/DMAP) system (one-step method) or through  the previous formation of the acyl chloride of the polyphenolic compounds and subsequent amidation  reaction (two-step method). The available phenolic groups on the macroporous polymers were determined  using the Folin Ciocalteu method; the radical scavenging properties of the materials prepared  were evaluated using the radical species 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,20-azinobis-[  3-ethylbenzothiazoline-6-sulfonic acid] radical cation (ABTS+). From the results, higher antiradical  capacities were obtained with the polymers in which the immobilization of the antioxidant molecules  was performed through the two-step method. The polymeric networks prepared in this work yielded  up to 13.2 lmol AOX\/g of dry polymer, which allowed a quantitative removal of the radicals tested in less  than 30 min.","palabras_clave":"Macroporous polymers |Antioxidants |Phenolic compounds |Polyphenols |Antiradical activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2741,"idioma_id":5,"titulo":"Evolución de los avances tecnológicos en la Educacion Superior. Período 1950-2010","resumen":"Se  sintetizan los avances tecnológicos y descubrimientos que se produjeron a nivel  mundial, aplicados en Educación Superior y específicamente en Argentina. El  período bajo análisis es 1950-2010. El estudio es descriptivo-documental,  utilizando documentos, monografías, artículos especializados en revistas de  investigación y publicaciones electrónicas. Se pretende dar respuestas a los  siguientes interrogantes: ¿cómo evolucionaron los avances tecnológicos a nivel  mundial?; ¿qué repercusión tuvieron en Argentina?; ¿qué cambios se fueron  vislumbrando en la educación superior?     Observación el ISSN corresponde al medio de distribución de la revista   'Temas Económicos', dicha revista tiene Propiedad Intelectual n° 87771  ","palabras_clave":"INTERACCIÓN|TIC|EDUCACIÓN SUPERIOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2742,"idioma_id":4,"titulo":"Convenient synthesis of 4-thiolactose, 3,4-dithiolactose and related thiooligosaccharides and disulfides. Inhibitory activity of the glycomimetics against a beta-galactosidase","resumen":"The ring-opening reaction of sugar 3,4-epoxides by 2,3,4,6-tetra-O-acetyl-1-thio-&#946;-D-galactopyranose (7) as nucleophile, led to (1,3)- and (1,4)-thiodisaccharides. High regio and diastereoselectivities were achieved in the synthesis of the per-O-acetyl derivative of the &#946;-D-Galp-S-(1,4)-4-thio-&#945;-D-Glcp-O-iPr (10). Analogues of the 4-thiolactoside 10 have been prepared, with the &#946;-D-Galp non-reducing end S-linked to D-Glcp, D-Gulp and D-Idop. Similar regioselective attack of 7 to C-4 of 2-propyl 3,6-di-O-acetyl-3,4-epithio-&#945;-D-galactopyranoside (6) led to 2-propyl 3,4-dithiolactoside derivative 15. During this reaction the free 3-SH  group of 15 underwent oxidative dimerization or oxidative coupling with the 1-SH of 7 to give the respective disulfides. Glycosylation of the thiol group of 15 using trichloroacetimidate derivatives of &#946;-D-Galp or &#946;-D-Galf afforded the corresponding branched dithiotrisaccharides. The free glycomimetics were evaluated as inhibitors of the E. coli &#946;-galactoside. The symmetric disulfide bis-(2-propyl 3,4-dithiolactosid-3-yl)-disulfide, obtained from 15, displayed the stronger inhibitory activity of these series of thioglycomimetics and proved to be a non-competitive inhibitor of the enzyme (Ki = 95 microM).","palabras_clave":"THIOOLIGOSACARIDE|THIOSUGAR|SUGAR DISULFIDE|RING-OPENING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2810,"idioma_id":4,"titulo":"Influence of Amorphous Block on the Thermal Behavior of Well-Defined Block Copolymers Based on &#61541;-Caprolactone","resumen":"In this work, we studied the thermal characterization of block copolymers based on å-caprolactone (CL). The copolymers were obtained by anionic polymerization techniques, using different co-monomers such as styrene (S) and dimetilsiloxane (DMS). The synthesized copolymers were characterizated by H-Nuclear Magnetic Resonance (1H-NMR), Size Exclusion Chromatography (SEC), and Fourier Transform Infrared Spectroscopy (FTIR). Isothermal crystallization was performed by Differential Scanning Calorimetry analysis (DSC), and Avrami?s theory was employed in order to obtain kinetics parameters of interest, such as the half-life for the crystallization process (t1\/2), the bulk crystallization constant (k), and the Avrami?s exponent (n). The spherulitic grow was measured by Polarized Optical Microscopy (POM) in order to determine the crystallization behavior. Poly(å-caprolactone) block (PCL) crystallization was analyzed by considering the physico-chemical characteristics of the neighboring blocks, PS or PDMS. According to the data obtained, the chemical nature of the neighbor block in the PCL based copolymer affects the kinetics parameters of the Avrami?s equation, as can be deduced by comparing the experimental results obtained for pure PCL and the studied block copolymers. On the other hand, the apparent thermal degradation activation energies Ead for both, PCL and block copolymers, were determined by Ozawa?s method. The incorporation of PDMS instead of PS improves the stability of the resulting copolymer, as if was observed by Thermogravimetric Analysis (TG).","palabras_clave":"Isothermal crystallization|Block copolymers|Poly(epsilon-caprolactone)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2812,"idioma_id":5,"titulo":"Implicancias de la enseñanza sobre el saber de los alumnos. El aprendizaje de fenómenos ópticos. Primera parte.","resumen":"En este trabajo se estudia qué y cómo aprenden los alumnos de educación secundaria, los modelos  que la ciencia propone para explicar la formación y visión de las imágenes ópticas, cuando se  implementa en el aula una propuesta didáctica diseñada en esta investigación. Se trabaja con curso  completo de 10 alumnos de educación secundaria de edades comprendidas entre los 15 y 16 años.  Se implementa un diseño cuasi-experimental (sin grupo de control) de tipo pretest - intervenciónpostest.  Se halla que los alumnos habrían experimentado un cambio radical en su modo de conocer  que le permitió dejar de concebir y explicar los fenómenos en términos de estados, hechos o datos,  realismo ingenuo y razonamiento monoconceptual a explicarlos en términos de procesos, y muchas  veces interacciones, activando modos de razonar plurivariados.  Se discute el impacto de la enseñanza y se advierte sobre los núcleos conceptuales cuyo aprendizaje  presenta más complejidad para los alumnos.","palabras_clave":"Aprendizaje de la óptica|Propuesta de enseñanza|imagen óptica|visión"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2815,"idioma_id":4,"titulo":"Simulation of photovoltaic centrals with dynamic shading (IF 5.261)","resumen":"The increase in the power of photovoltaic systems involves a signicantgrow in the number of modules that make them up. The known problemscaused by the shading usually are not taken into account in the design ofa photovoltaic central. The aims of this study are to obtain a model forsimulation of photovoltaic plants, representing the array under di\u000Berent conditionsof dynamic shading, and to investigate its e\u000Bects on congurations ofmodules array and converters. Performance measures are also discussed inorder to nd those most suitable for plants comparison in this context. Analyzingthe eciency of the maximum power point tracker and the inverterunder di\u000Berent conditions of dynamic shading, using one or more inverters, abetter performance is generally achieved by reducing the number of modulesin series and by increasing the number of those in parallel. However, theresults show that the conguration with maximum performance depends onthe conditions of shading. Photovoltaic plants composed of many modulescan be studied using the proposed simulation model. These studies allow tond designs with higher performance.","palabras_clave":"Simulation model|Photovoltaic|Neural networks|Dynamic shading"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2816,"idioma_id":5,"titulo":"Cálculo y modelación de un tanque cilíndrico de hormigón armado según ACI 350\/01 y comparación con CIRSOC 201\/82\u201D Segunda Parte","resumen":"El hormigónarmado es uno de los materiales más utilizado para la construcción de tanquesde almacenamiento. El presente artículo es el primero de un trabajo que procuradesarrollar conceptos del cálculo de los tanques cilíndricos bajo presioneshidrostáticas.En unasegunda parte se tratará un enfoque de diseño según el Código ACI 350-01, dadoque el CIRSOC 201\/05 no trata el diseño de este tipo de estructuras.","palabras_clave":"ACI 350|Tanques de hormigón"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2817,"idioma_id":4,"titulo":"Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at s&#8730;=7 TeV with the ATLAS detector","resumen":"Results of a search for new phenomena in events with an energetic photon and large missing transverse momentum in proton-proton collisions at &#8730;s=7&#8201;&#8201;TeV are reported. Data collected by the ATLAS experiment at the LHC corresponding to an integrated luminosity of 4.6&#8201;&#8201;fb-1 are used. Good agreement is observed between the data and the standard model predictions. The results are translated into exclusion limits on models with large extra spatial dimensions and on pair production of weakly interacting dark matter candidates.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2818,"idioma_id":5,"titulo":"Narrar los bombardeos de 1955 hoy: arte, política y derechos humanos en Argentina","resumen":"Este trabajo presenta los resultados preliminares de una indagación desde una perspectiva comunicacional sobre las producciones culturales realizadas en los últimos años en torno a los bombardeos a la Plaza de Mayo, en el centro de la Ciudad de Buenos Aires, en el año 1955. Relevamos un corpus de piezas culturales contemporáneas, con heterogeneidades en cuanto a soportes, circuitos de exhibición, lenguajes y materialidades. Se trata de un repertorio complejo de unidades de comunicación dedicadas a los bombardeos: historietas, muestras de arte, sitios web, obra de teatro, entre otras. Cada pieza y cada soporte ?comunica? de manera diferencial estos hechos de violencia política en nuestro país, y por eso mismo conforman un repertorio heterogéneo que pone en tensión no sólo lenguajes y\/o tecnologías de distintos linajes, sino también temporalidades históricas que tironean de las posibles significaciones otorgadas al evento. En este ensayo, intentamos aportar elementos para reflexionar sobre las modalidades del recuerdo y de los sesgos particulares que adquiere cuando se interviene desde producciones artísticas. En ese sentido, proponemos re-elaborar los modos en que estas producciones han colaborado en la ampliación del campo de los derechos humanos a partir de las regulaciones jurídicas, complementarias a la ley de reparación histórica, en torno a la definición de víctimas del terrorismo de estado.","palabras_clave":"BOMBARDEOS|ARTE|VISUALIDAD|HEGEMONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2819,"idioma_id":5,"titulo":"Informe Anual 2013 - Plan de trabajo 2014 GETyP","resumen":"A través del Informe Anual 2013 y Plan de Trabajo 2014 se pretende dar difusión de las actividades del Grupo de Estudio del Trabajo y la Producción (GETyP) perteneciente al Departamento de Ingeniería Industrial de la UTN  Facultad Regional La Plata.","palabras_clave":"INFORME"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2820,"idioma_id":4,"titulo":"Toxicity of  the  effluent  from  an  anaerobic  bioreactor  treating  cereal  residues  on  Lactuca  sativa","resumen":"Effluents generated during the process of anaerobic digestion should be   treated before their disposal into the environment. The aim of this   study was evaluating the effectiveness of the effluent treatment system   from an anaerobic bioreactor, assessing the toxicity reduction with the Lactuca sativa   seed germination and root elongation inhibition test. Three sampling   points were selected along the effluent treatment system: inflow into   the first treatment pond, outflow from the third pond and recirculated   flow to the bioreactor. Effluent dilutions tested for each sampling   point were 25% and 50% (v\/v), undiluted sample and controls. The pH,   conductivity, temperature, dissolved oxygen, BOD5 and COD   were measured. The decrease in the organic and inorganic loads was   correlated with a reduction in the phytotoxicity. The use of the seed   toxicity test allows evaluating the quality and effectiveness of the   studied effluent treatment system.","palabras_clave":"Anaerobic digestion|Relative growth index|Germination index|Biomonitoring|Effluent treatment system|Phytotoxicity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2821,"idioma_id":4,"titulo":"Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens.","resumen":"A recombinant MVA expressing mature VP2 protein of infectious bursal disease virus (IBDV) was constructed as an attempt to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response with the presence of IBDV-seroneutralizing antibodies in SPF chickens. The results suggest a correct conformational structure of the VP2 protein expressed from MVA-VP2 as epitopes located on VP2 are discontinuous. To our knowledge, we report for the first time the usefulness of MVA based vectors for developing recombinant vaccines for poultry.","palabras_clave":"MVA|VP2 PROTEIN|IBDV|CHICKEN IMMUNITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2823,"idioma_id":4,"titulo":"First detection of Rio Negro Virus (Venezuelan Equine Encephalitis complex subtype VI) in Córdoba province, Argentina.","resumen":"Rio Negro Virus (RNV) (Venezuelan Equine Encephalitis subtype VI) circulates only in Argentina; in Northern provinces, isolates have been obtained from mosquitoes and rodents since 1980 and have been associated with acute febrile illness in humans. But there are not studies in the central area of the country. We carried out molecular and serological detection of RNV in Córdoba, province of the central part of the country, in mosquitoes and humans, respectively. One mosquito pool tested positive for alphavirus RNA by reverse transcriptase-nested polymerase chain reaction (RT-nested PCR), which was sequenced and grouped with RNV. Serological studies detected antibodies to RNV in one human serum sample, which was obtained during the period of molecular detection. This is the first report of RNV circulation in the central area of Argentina, showing an expansion of its original distribution. These results highlight the importance of strengthening surveillance procedures in endemic areas, as well as in new regions where RNV may emerge.","palabras_clave":"Rio Negro virus|Venezuelan equine encephalitis|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2824,"idioma_id":4,"titulo":"Efficient and suitable preparation of N-sulfonyl-1,2,3,4- tetrahydroisoquinolines and ring analogues using recyclable H 6P 2W 18O 62·24H 2O\/SiO 2 catalyst","resumen":"Silica gel-supported H6P2W18O6224H2O is an efficient and recyclable catalyst for thesynthesis of biologically important molecules. Several substituted N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues can be prepared in very good yields and purityby direct reaction of N-aralkylsulfonamides and sym-trioxane by a Pictet-Spenglerreaction in the presence of a catalytic amount of silica gel-supported H6P2W18O6224H2O.Reactions were performed in a low volume of toluene, at 70 8C and for a short time,typically 15 to 30 min. The title heterocyclic compounds were prepared in very good yields(60%?95%) using the described procedure results in a clean and useful alternative, whichhas the advantages of a greener methodology with operative simplicity, use of a reusableand non-corrosive solid catalyst, soft reaction conditions, low reaction times, and goodyields.","palabras_clave":"Silica-supported Wells-Dawson catalyst | Pictet-Spengler reaction| N-sulfonyl-1,2,3,4-tetrahydroisoquinolines"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2825,"idioma_id":5,"titulo":"Avances sobre Eficiencia y Sostenibilidad en la Iluminación de Recintos Urbanos y Edificios","resumen":"El permanente crecimiento del consumo energético que afronta Argentina hacen necesaria, la generación de conocimientos y desarrollo tecnológico enfocados al uso eficiente y racional de la iluminación urbana y de edificios. En dicho sentido se desarrolla un proyecto sobre: Eficiencia y sostenibilidad en la iluminación de recintos urbanos y edificios donde se estudian los siguientes temas: a) Calificación energética e indicadores de eficiencia en edificios y equipos de iluminación. b) Evaluación de la calidad del servicio de la iluminación urbana, mediante indicadores objetivos. c) Efecto sobre el diseño de sistemas de iluminación, eficiencia e impacto ambiental. d) Evaluación del impacto ambiental de la polución lumínica en entornos urbanos. e) Desarrollo de un sistema de procesamiento de imágenes digitales para la medición de la calidad de la iluminación en vías de transito vial. En el presente trabajo, se describen los avances y resultados sobre dichos temas desarrollados en el marco del proyecto.PROGRESS ON EFFICIENCY AND SUSTAINABILITY IN URBAN AND BUILDINGS LIGHTING The permanent growth in energy consumption faced by Argentina, makes necessary knowledge generation and technology development focused on the efficient and rational use of urban and buildings lighting. In that sense a project called Efficiency and sustainability in urban and buildings lighting is the frame of study the following topics: a) Energy rating and efficiency indicators for buildings and lighting equipment. b) Assessment of quality service of urban lighting .c)&nbsp; Effect of efficiency from lighting design on environmental impact. d)&nbsp; Environmental impact of light pollution in urban lighting installations. e)&nbsp; Development of a digital image processing for measuring the quality of lighting in road traffic routes. In this paper, we describe the progress and results on these topics developed in the frame of this project.","palabras_clave":"EFICIENCIA ENERGETICA|ALUMBRADO URBANO|IMPACTO AMBIENTAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2826,"idioma_id":4,"titulo":"High density lipoprotein is an inappropriate substrate for hepatic lipase in postmenopausal women","resumen":"Background: HDL antiatherogenic effects would not only depend on its concentration but also on its biological quality. Hepatic lipase (HL) action on HDL acts in one of the last steps of reverse cholesterol transport. Cardiovascular risk increases after menopause, however HDL does not decrease even when HL is increased. We evaluated HDL capacity as a substrate of HL in healthy postmenopausal women (PMW). Methods: We studied 20 PMW (51?60 y) and 20 premenopausal (PreMW) (26?40 y). In fasting serum, lipid?lipoprotein profile and HDL composition were assessed. Optimal assay conditions for HDL\/HL ex vivo incubationwere established. Increasing HDL?triglyceride concentrations (0.015 to 0.20 mmol\/l) were incubated with post-heparin plasma obtained from a single healthy donor as a source of HL. Free fatty acids were measured and kinetic parameters calculated: Km(app), inverse to enzyme affinity, and Vmax. Results: HDL composition in PMWexhibits triglyceride enrichment (p&lt;0.001). Kinetic analysis revealed higher Km(app) in PMW[130 (40?380) vs 45 (20?91) mmol\/l, p&lt;0.0001)] correlating directly with HDL?triglycerides (r=0.7, p=0.0001). Catalytic efficiency, Vmax\/Km(app) was reduced when compared to controls (p=0.0001). Conclusion: Triglyceride-enriched HDL fromPMWconstitutes a poor substrate for HL suggesting that this particlemay not exert efficiently its antiatherogenic function, regardless of plasma concentration.","palabras_clave":"HIGH DENSITY LIPOPROTEIN|POSTMENOPAUSE|HDL FUNCTIONALITY|HEPATIC LIPASE|KINETICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2827,"idioma_id":4,"titulo":"Microstructure and reactivity effects on the performance of Nd2NiO4Dd oxygen electrode on Ce0.9Gd0.1O1.95 electrolyte","resumen":"The effect of electrode microstructure on the electrochemical behavior of symmetricalNd2NiO4þd\/Ce0.9Gd0.1O1.95\/Nd2NiO4þd cells was studied by Electrochemical ImpedanceSpectroscopy as a function of temperature (500 &lt; T &lt; 750 C) and oxygen partial pressure(104 &lt; pO2 &lt; 1 atm). Nd2NiO4þd powders were synthesized by Solid State Reaction, HMTAand Citrates. The samples observed by Scanning Electron Microscopy presented verydifferent microstructures. Three characteristic processes were distinguished at high,medium and low frequency. High frequency contribution was attributed to oxygen iontransfer electrode\/electrolyte. Medium frequency contribution was related to oxygeninterstitial bulk diffusion and oxygen incorporation in those cases in which the surface ofsmall particles is affected by chemical reactivity with the electrolyte. The low frequencycontribution was attributed to dissociative adsorption for electrodes with small particlesizes and high porosity, and a co-limited process of adsorption and gas diffusion for anelectrode with dense microstructure and low porosity.","palabras_clave":"Nd2NiO4-d|Ce0.9Gd0.1O1.95|Oxygen electrode"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2828,"idioma_id":4,"titulo":"Charge accumulation and electron transfer kinetics in Geobacter sulfurreducens biofilms","resumen":"Electroactive bacteria can use a polarized electrode as final electron acceptor, allowing the use of electrochemical techniques for a very accurate quantification of its respiration rate. Biofilm cell respiration has been recently demonstrated to continue after the interruption of electrode polarization since these bacteria can store electrons in the haemgroups of exocytoplasmic cytochromes. Interestingly, it has been shown that when the electrode is connected again, stored electrons can be recovered as a current superimposed to the basal steady state current produced by biofilm respiration. This work presents a model for the biofilm-catalysed electron transfer mechanism that reproduces the current profile obtained upon electrode reconnection. Themodel allows the estimation of kinetic parameters forinternalization of the reduced substrate by the cells and the subsequent reduction of cell internal cytochromes, the electron transfer to mediators in the exterior of the cell, charge transport across the biofilm matrix to the electrode through fixedmediators and, finally, the oxidation of cytochromes at the biofilm\/electrode interface. Based on these estimates, the distribution of stored charge within the biofilm can also be calculated. The results indicate that the processes involved in electron transfer from acetate to internal cytochromes represent themain limitation to current production, showing that both electron transport through the matrix of cytochromes and interfacial electron transfer are orders of magnitudefaster than this process. Stored charge, on the other hand, is an order ofmagnitude higher inside the cells compared with that in the conductive matrix, suggesting that internal&nbsp; cytochromes are approximately ten times more abundant inside the cells than in the conductive matrix.","palabras_clave":"Electron transport|Biofilms|Geobacter"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2829,"idioma_id":4,"titulo":"Telomere structure and telomerase in health and disease (Review)","resumen":"Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells. In human somatic cells, proliferation potential is strictly limited and senescence follows approximately 50-70 cell divisions. In most tumor cells, on the contrary, replication potential is unlimited. The key role in this process of the system of the telomere length maintenance with involvement of telomerase is still poorly studied. Undoubtedly, DNA polymerase is not capable of completely copying DNA at the very ends of chromosomes; therefore, approximately 50 nucleotides are lost during each cell cycle, which results in gradual telomere length shortening. Critically short telomeres cause senescence, following crisis and cell death. However, in tumor cells the system of telomere length maintenance is activated. Much work has been done regarding the complex telomere\/telomerase as a unique target, highly specific in cancer cells. Telomeres have additional proteins that regulate the binding of telomerase. Telomerase, also associates with a number of proteins forming the sheltering complex having a central role in telomerase activity. This review focuses on the structure and function of the telomere\/telomerase complex and its altered behavior leading to disease, mainly cancer. Although telomerase therapeutics are not approved yet for clinical use, we can assume that based on the promising in vitro and in vivo results and successful clinical trials, it can be predicted that telomerase therapeutics will be utilized soon in the combat against malignancies and degenerative diseases. The active search for modulators is justified, because the telomere\/telomerase system is an extremely promising target offering possibilities to decrease or increase the viability of the cell for therapeutic purposes. ","palabras_clave":"telomere|telomerase|cancer|therapeutic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2830,"idioma_id":4,"titulo":"Advance in the study of limonene epoxidation with H2O2 catalized by Cu(II) complex heteropolytungstates","resumen":"The complex heteropolyoxotungstates of formula K10[M4(H2O)2(PW9O34)2]·20H2O (PWM) with M=Co(II),Zn(II), Cu(II) and Mn(II), and their precursor, Ä-Na8HPW9O34·19H2O (Ä-PW9), were evaluated as bulk inlimonene epoxidation using H2O2 as oxidant, 1,2 dicloroethane as solvent and metiltricaprilamonium chloride(Aliquat 336) as a phase transfer agent at 2 °C. In these biphasic conditions PWCu was the most activephase. Subsequently this phase was supported on ã-Al2O3, the metal load was determined by AAS, ICP andX-ray fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.10[M4(H2O)2(PW9O34)2]·20H2O (PWM) with M=Co(II),Zn(II), Cu(II) and Mn(II), and their precursor, Ä-Na8HPW9O34·19H2O (Ä-PW9), were evaluated as bulk inlimonene epoxidation using H2O2 as oxidant, 1,2 dicloroethane as solvent and metiltricaprilamonium chloride(Aliquat 336) as a phase transfer agent at 2 °C. In these biphasic conditions PWCu was the most activephase. Subsequently this phase was supported on ã-Al2O3, the metal load was determined by AAS, ICP andX-ray fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.Ä-Na8HPW9O34·19H2O (Ä-PW9), were evaluated as bulk inlimonene epoxidation using H2O2 as oxidant, 1,2 dicloroethane as solvent and metiltricaprilamonium chloride(Aliquat 336) as a phase transfer agent at 2 °C. In these biphasic conditions PWCu was the most activephase. Subsequently this phase was supported on ã-Al2O3, the metal load was determined by AAS, ICP andX-ray fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.2O2 as oxidant, 1,2 dicloroethane as solvent and metiltricaprilamonium chloride(Aliquat 336) as a phase transfer agent at 2 °C. In these biphasic conditions PWCu was the most activephase. Subsequently this phase was supported on ã-Al2O3, the metal load was determined by AAS, ICP andX-ray fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.ã-Al2O3, the metal load was determined by AAS, ICP andX-ray fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.fluorescence and the preservation of PWCu structure was confirmed by XPS and Raman microprobe.PWCu\/ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.ã-Al2O3 was evaluated at 70 °C with acetonitrile as solvent. The pure PWCu showed a higher conversionto epoxide but lower selectivity due to the formation of secondary products.","palabras_clave":"Complex heteropolytungstates|Limonene epoxidation|Hydrogen peroxide"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2831,"idioma_id":4,"titulo":"Different effects by sex on hypothalamic-pituitary axis of prepubertal   offspring rats produced by in uterus and lactational exposure to di-(2-ethylhexyl)phthalate (DEHP)","resumen":"This study investigated the effect of pre and perinatal exposure to   di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that   regulate reproduction in prepubertal male and female rats. DEHP at   doses of 3 and 30&nbsp;mg\/kg&nbsp;bw\/day was administered orally in the drinking   water to dam rats since pregnancy onset until the moment of pups   sacrifice at 15 days of age. In these animals gonadotropin serum level   and the hypothalamic contents of the amino acids aspartate, glutamate   and gamma-aminobutyric acid were determined. No changes in gonadotropin   levels and amino acid neurotransmitters were detected at the low dose in   both sexes. However, DEHP administered at high dose (30&nbsp;mg\/kg&nbsp;bw\/day)   to dams produced a significant decrease in the inhibitory   neurotransmitter GABA and an increase in the stimulatory   neurotransmitter aspartate in prepubertal male offspring rats. These   modifications were accompanied by gonadotropin serum levels increase. On   the contrary, in treated female rats this chemical increased both,   aspartate and GABA, which exert a characteristic stimulatory action on   gonadotropin in 15-day-old normal females. This study provides new data   about changes produced by DEHP on the hypothalamic amino acid   neurotransmitters involved in the neuroendocrine reproductive   regulation, in prepubertal male and female rat offspring from dams   exposed during gestational and lactational periods. These alterations   induced by DEHP exposure could be related to the gonadotropin   modifications also described in this work, and with changes in the   production of sexual hormones previously reported by other authors.","palabras_clave":"DEHP|Lactation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2832,"idioma_id":4,"titulo":"Generalised pollination system of Erythrina dominguezii (Fabaceae : Papilionoideae) involving hummingbirds, passerines and bees","resumen":"Plants in the genus Erythrina are pollinated by birds, such that passerine pollination is the plesiomorphic state, whereas hummingbird pollination is the derived character. Phylogenetic studies suggest that Erythrina dominguezii belongs to a basal clade characterised as pollinated by both passerines and hummingbirds. Here, we characterise the pollination system of E. dominguezii. Floral morphology, nectar traits, breeding system, visitation rates and pollen deposition by its floral visitors were studied. Floral morphology of E. dominguezii showed traits associated with both passerine and hummingbird pollination. Nectar sugar concentration showed an intermediate value but closer to the hummingbird type; however, it was rich in hexose, which is typical of the passerine type. Approximately 5% of the flowers set fruits under free pollination. Almost 80% of recorded flowers were visited by birds, with the rest visited by hymenopterans (bumblebees and honeybees). Among avian pollinators, five species of hummingbirds and three passerine species were identified as pollinators. The hummingbird Chlorostilbon lucidus was the most efficient visitor in terms of pollen deposition and was second in frequency of visits. The passerine Icterus cayanensis was second in efficiency at depositing pollen and was the most frequent pollinator. Our results show that E. dominguezii has a generalised pollination system. In addition, we report a new case of closed flowers and secondary nectar presentation. This is the first study that compares effectiveness among different pollinators in Erythrina.","palabras_clave":"PAPILIONOIDEAE|ERYTHRINA|REPRODUCTIVE BIOLOGY|GENERALIZED POLLINATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2854,"idioma_id":5,"titulo":"Sistema de informacion  social de un Hospital","resumen":"En el trabajo ?Sistema de Información Social en un Hospital Público? se desarrolló un modelo de Balance Social de un hospital público que  informa como la organización asume sus responsabilidades en relación a los recursos humanos, a su comunidad vinculada y a la naturaleza. A su vez, ayuda al  Ministerio de Salud en la identificación y en la formulación de políticas públicas. La construcción del Balance Social y su aplicación permite monitorear la estrategia y el servicio de salud y por consiguiente la salud de la sociedad.  El Balance Social es una guía práctica que le permite a los directivos saber si la institución se dirige hacia la consecución final de su meta. Si bien este instrumento no soluciona los problemas que enfrenta a diario el hospital, el mismo es de gran ayuda si se aplica correctamente porque le permite reaccionar, realizar y difundir un cambio de estrategia si es necesario. Si bien cada hospital presenta realidades y problemáticas diferentes, se desarrolló un marco conceptual que sirve de tutor y ayuda a otros establecimientos asistenciales en la aplicación de esta herramienta. El marco teórico utilizado fue planeamiento estratégico, cuadro de mando integral, evaluación del desempeño y presentación del modelo de balance social.","palabras_clave":"Hospital|Responsabilidad Social|Balance Social"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2892,"idioma_id":4,"titulo":"Of volcanoes and insects: the impact of the Puyehue-Cordon Caulle ashfall on populations of invasive social wasps, Vespula spp. in Southern Argentina.","resumen":"Volcanic eruptions have important effects on terrestrial ecosystems. The biotic effects of volcanic ash on insect populations vary from widespread and catastrophic to subtle and localized. Volcanic eruptions may increase insect mortality through the effects of the ash plume, and these vary by taxon or specific biological features. The Puyehue?Cordon Caulle Volcanic Complex is the most recent eruption in Patagonia. Here we explore and describe the effects of the eruption of this volcanic complex on invasive Vespula spp. populations. These wasps are very abundant social hymenoptera that have recently invaded Patagonia. We placed baited traps  following the gradient of deposited ash, and revisited them once a week during February to April. No wasps were caught where ash deposition levels exceeded 3.0 cm. The number of wasps caught in sites with minimal  ash deposits was similar to that of previous years. In locations where ash layers are intermediate, a few wasps were observed, but only during the peak of wasp abundance. We show that Vespula spp. populations were  severely affected by the ash deposition and plume, caused by this eruption. These results show catastrophic effects of ash deposition over a large area, even at great distances from the eruption epicenter. We conclude that wasp mortality explained by the volcanic eruption may  reach distant areas, and cause local extinction. In areas where active volcanoes are common, invasive insects may encounter an additional obstacle in their invasion success.","palabras_clave":"YELLOWJACKETS|INSECTS|EXOTIC|ASH DEPOSITION|PATAGONIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2900,"idioma_id":5,"titulo":"Caracterización del ciclo estral  en la perra Dogo argentino por endoscopía vaginal","resumen":"El Dogo argentino es la única raza de perro argentina. Dada la creciente demanda de esta raza canina se hace necesario conocer los parámetros fisiológicos reproductivos y las patologías propias. El objetivo de la primera parte de este trabajo fue reconocer los diferentes momentos del ciclo estral.","palabras_clave":"DOGO|REPRODUCCION|CICLO ESTRAL|ENDOSCOPIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2902,"idioma_id":4,"titulo":"Tha aggregation of Brucella abortus occurs under microaerobic conditions and promotes dessication tolerance and biofilm formation.","resumen":"Brucella abortus causes brucellosis mainly in cattle. The infection is transmitted to  humans by ingestion of animal products or direct contact with infected material. While  the intracellular lifestyle of Brucella is well characterized, its extracellular survival is  poorly understood. In nature, bacterial persistence is associated with biofilms, where  aggregated cells are protected from adversity. The inability of Brucella abortus to  aggregate under aerobiosis and that fact that the replicative niche of Brucella is  characterized by microaerobic conditions prompted us to investigate the capacity of this  pathogen to aggregate and grow in biofilms under microaerobiotic conditions. The  results show that B. abortus aggregates and produces biofilms. The aggregates tolerate  desiccation better than planktonic cells do, adhere and displace even in the absence of  the lipopolysaccharide-O antigen, flagella, the transcriptional regulator VjbR, or the  enzymes that synthesize, transport, and modify cyclic &#946; (1,2) glucan.","palabras_clave":"aggregation|biofilm|Brucella|flotation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2905,"idioma_id":4,"titulo":"Search for pair production of heavy top-like quarks decaying to a high-pT W boson and a b quark in the lepton plus jets final state at &#8730;s=7 TeV with the ATLAS detector","resumen":"A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuminga signi&#64257;cant branching ratio for subsequent decay into a W boson and a b quark. The search is basedon 4.7 fb&#8722;1 of pp collisions at &#8730;s =7 TeV recorded in 2011 with the ATLAS detector at the CERN LargeHadron Collider. Data are analyzed in the lepton + jets &#64257;nal state, characterized by a high-transverse momentum isolated electron or muon, large missing transverse momentum and at least three jets. Theanalysis strategy relies on the substantial boost of the W bosons in the tt¯ signal when mt' >~ 400 GeV.No signi&#64257;cant excess of events above the Standard Model expectation is observed and the result ofthe search is interpreted in the context of fourth-generation and vector-like quark models. Under theassumption of a branching ratio BR(t&#8594; W b) = 1, a fourth-generation tquark with mass lower than656 GeV is excluded at 95% con&#64257;dence level. In addition, in light of the recent discovery of a new bosonof mass &#8764;126 GeV at the LHC, upper limits are derived in the two-dimensional plane of BR(t&#8594; W b) versus BR(t&#8594;Ht), where H is the Standard Model Higgs boson, for vector-like quarks of various masses.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2906,"idioma_id":5,"titulo":"Lithospermum officinale, nuevo registro de Boraginaceae para la flora argentina.","resumen":"LITHOSPERMUM OFFICINALE, NUEVO REGISTRO DE BORAGINACEAE PARA ARGENTINA","palabras_clave":"nuevo registro |Boraginaceae|Lithospermum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2907,"idioma_id":4,"titulo":"A direct and quantitative image of the internal nanostructure of non-ordered porous monolithic porous carbon using FIB nanotomography","resumen":"Adirect study of the shape, size andconnectivity of nonordered  pores in carbon materials is particularly challenging. A  new method that allows direct three-dimensional (3D)  investigations of mesopores in monolithic carbon materials  and quantitative characterization of their physical properties  (surface area and pore size distribution) is reported. Focused  ion beam (FIB) nanotomography technique is performed by  combination of focused ion beam and scanning electron  microscope. Porous monolithic carbon is produced by  carbonization of a resorcinol-formaldehyde gel in the presence  of a cationic polyelectrolyte as a pore stabilizer.","palabras_clave":"focused ion beam|nanotomography|mesoporous carbon|image analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2908,"idioma_id":5,"titulo":"Caracterización de residuos de la industria pesquera provenientes de los deshechos de la merluza (Merluccius hubbsi) del golfo San Jorge","resumen":"La merluza (Merluccius hubbsi) es la base de la industria pesquera en la región del Golfo San Jorge. Datos aportados por la Secretaría de Pesca del Chubut indican que los volúmenes de captura anual alcanzan las 50.000 toneladas. La mayor parte se procesa en forma de fileteado, y esta situación representa pérdidas de alrededor del 40% en peso de material crudo que en parte es descartado y en parte es utilizado para la producción de harina de pescado. Pero entre el material de descarte de la merluza, existen compuestos de alto valor nutricional que podrían extraerse para la preparación de productos de mayor valor comercial, como por ejemplo los aceites ricos en ácidos grasos tipo omega 3. Existen reportes sobre composición de vísceras e hígados presentes en los residuos de merluza capturada en otras regiones del atlántico (Grompone y col. 2004) pero no se han encontrado reportes previos para la región patagónica con datos sobre composición de residuos del procesado y su variación en las diferentes épocas de captura, por lo que esta tarea constituye uno de los objetivos del grupo de investigación. Los datos obtenidos permitirán en una próxima etapa evaluar la factibilidad económica financiera de la implementación de un proceso de producción de aceites de merluza con fines comerciales. En este trabajo se presentan los datos de composición proximal de los residuos de hígados y restos de vísceras procedentes del descarte de la merluza de dos diferentes fechas de captura, correspondientes a los meses de primavera 2011 y verano 2012.","palabras_clave":"MERLUCCIUS HUBBSI|COMPOSICION PROXIMAL|LIPIDOS |ACIDOS GRASOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2909,"idioma_id":4,"titulo":"Functional vision barriers: a new concept analyzed in terms of human visual performance.","resumen":"In this work, we propose to introduce a new category of barriers that we have called 'functional vision barriers'. With this expression we refer to lighting and visual elements that may complicate or hinder functional vision, and which may make life even more difficult for people with visual defects. These barriers appear as a consequence of certain negative effects on people, caused either by a poor design of the visual stimulus or by the visual environment that surrounds it, where lighting is one of the main factors. We use the term ?functional vision? because this expression refers to the ability of the visual system to perform everyday tasks.                             To exemplify this proposal, we have analyzed some of our previous results that respond to situations that can be considered ?functional vision barriers?: 1) stimuli with low luminance contrast information, where the addition of chromatic contrast improves visual performance, and 2) tasks that are carried out in the presence of a glare source in the visual field, diminishing visual performance and reducing brightness perception.                       ","palabras_clave":"FUNCTIONAL VISION|VISUAL PERFORMANCE|BRIGHTNESS CONSTANCY|DISABILITY GLARE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2910,"idioma_id":4,"titulo":"Microwave response of anisotropic magnetorheological elastometers, model and experiments","resumen":"We present ferromagnetic resonance measurements of Fe3O4 nanoparticles which have been dispersed in an  elastomeric polymer [polydimethylsiloxane (PDMS)] at two different concentrations (5% and 15% w\/w), and  then cured in the presence of a uniform magnetic field. With this procedure it is possible to align the particles  forming unidimensional needlelike cylindrical agglomerates with a relatively high length\/diameter ratio. The  dynamical response of this nanostructured composite has been characterized using ferromagnetic resonance  at K band (24 GHz) and Q band (34 GHz). In both cases we have observed an anisotropic behavior in the  resonance field when the external magnetic field is rotated from the direction of the needles to the perpendicular  plane. However, the measured variation is considerably lower than the values expected for an array of perfectly  homogeneous long cylinders in which the elongated shape causes a uniaxial anisotropy. Results have been  analyzed using the standard Smit and Beljers formalism, considering a phenomenological shape factor, P, that  accounts for the reduced anisotropy. Also an ellipticity factor in the cross section of the needles, r, and Gaussian  fluctuations of the shape factor, &#963;P, are needed to explain the observed angular variation of the linewidth. The  values of these parameters are consistent with data obtained at K and Q bands, supporting the proposed model,  although some differences have been found for the two studied concentrations.","palabras_clave":"MAGNETORHEOLOGICAL|ELASTOMER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2911,"idioma_id":4,"titulo":"Search for a light Higgs boson decaying to long-lived weakly-interacting particles in proton-proton collisions at $\\sqrt{s}=7$ TeV with the ATLAS detector","resumen":"A search for the decay of a light Higgs boson (120\u2013140&nbsp;GeV) to a pair of weakly interacting, long-lived particles in 1.94&#8201;&#8201;fb-1 of proton-proton collisions at &#8730;s=7  &#8201;&#8201;TeV recorded in 2011 by the ATLAS detector is presented. The search   strategy requires that both long-lived particles decay inside the muon   spectrometer. No excess of events is observed above the expected   background and limits on the Higgs boson production times branching   ratio to weakly interacting, long-lived particles are derived as a   function of the particle proper decay length.","palabras_clave":"HIGGS|SEARCHES|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2912,"idioma_id":4,"titulo":"Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice.","resumen":"This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol\/ìl, i.c.v.), and reversed OB-induced depressivelike behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB.","palabras_clave":"ghrelin|tail suspention test|olfactory bulbectomy|hyperactivity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2913,"idioma_id":4,"titulo":"Diet and feeding of the nassariid Buccinanops cochlidium from northern Patagonia, Argentina","resumen":"The Nassariidae are considered to be carrion feeders. Nevertheless, the feeding habits of this family also include herbivory, detritivory and carnivory. In the present study, we observed the diet and feeding behaviour of Buccinanops cochlidium from northern Patagonic waters. B. cochlidium fed mainly on living bivalves and, as an opportunistic carrion feeder, on diverse dead animals. It was commonly observed to feed in groups. When one individual of B.cochlidium caught a prey, other individuals approached and opportunistically fed on the remains. Juveniles fed exclusively on carrion, including prey recently killed by conspecific adult snails (39.5% of the scavenging events). Carrion represented 57.8% of the B. cochlidium diet on the whole. Predation seemed to be related to the size of B. cochlidium individuals, in particular, the foot, which is used to hold and manipulate the prey. We observed no feeding activity for gravid B. cochlidium females in the field. In summary, our results show that B. cochlidium is a carnivorousspecies, both as a scavenger and as a predator, that feeds mainly on dead crabs and living bivalves. Adults of B. cochlidium predated actively and fed opportunistically on dead animals of larger sizes, whereas hatchlings and juveniles fed exclusively on carrion, including by-products generated by the predation of larger B. cochlidium individuals.","palabras_clave":"DIET|BUCCINANOPS|PATAGONIA|GASTROPODA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2914,"idioma_id":4,"titulo":"Functional properties and microstructure of cowpea cultivated in the NEA-Argentina","resumen":"The goal of this work was to analyze the effect of different treatments on functional properties (Color prameters, water holding capacity, oil holding capacity, water imbibition capacity, protein solubility andapparent viscosity) and microstructure of three cowpea varieties. Proteins present in flours obtainedfrom heat-treated seeds exhibited a significant increase in water and oil absorption values, waterimbibition capacity, and apparent viscosity, whereas solubility decreased. Color determinations on floursshowed a reduction in L* and H*, and an increment in C* with treatment intensity. Structural changes inseeds would explain the variations in the functionality of flours. This study shows that cooking andautoclaving affect significantly the functional properties of flours, while soaking had a lower impact. Theknowledge about these changes will be very useful for developing and obtaining new preparations basedon cowpea flour.","palabras_clave":"Cowpea|Microstructure|Thermal treatments|Functional properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2915,"idioma_id":5,"titulo":"Compuestos con actividad tripanocida de Mikania micrantha (Asteraceae)","resumen":"La tripanosomiasis americana o enfermedad de Chagas es una enfermedad parasitaria causada por el protozoo Trypanosoma cruzi. Se estima que 10 millones de personas están infectadas con el parásito y que 25 millones están en riesgo de contraer la enfermedad (1). Esta parasitosis es endémica en América Latina y en Argentina la padecen aproximadamente 2 millones de personas, de las cuales entre un 20 a un 30% desarrollan cardiopatías severas. Para el tratamiento de la enfermedad de Chagas se cuenta únicamente con dos fármacos: nifurtimox y benznidazol, que fueron desarrollados en la década del ´70. Estas drogas son efectivas solamente durante la etapa aguda de la enfermedad y son poco toleradas por sus severos efectos adversos. En trabajos previos se informó la actividad sobre epimastigotes de T. cruzi del extracto orgánico (CH2Cl2-MeOH [1:1]) de Mikania micrantha (2). En este contexto, el&nbsp; objetivo de este trabajo fue aislar los compuestos con actividad tripanocida presentes en el extracto. El extracto orgánico de M. &nbsp;micrantha se fraccionó por cromatografía en columna de Silicagel obteniéndose un total de 8 fracciones (MM1-MM8). El perfil cromatográfico por HPLC de las fracciones activas MM3 y MM4 permitió detectar 3 compuestos mayoritarios con máximos de absorción UV de 219, 217 y 223 nm y tiempos de retención de 16.5, 19.2 and 20.6 min, respectivamente (figuras 1 y 2).             A partir de estas dos fracciones se aisló un compuesto activo que presentó una concentración inhibitoria 50% (IC50) de 2.70 µg\/ml sobre epimastigotes de T. cruzi. La citotoxocidad del compuesto se evaluó sobre células VERO, obteniéndose una concentración citotóxica 50% (CC50) de 29.87 µg\/ml. Por espectroscopia infrarroja se pudo detectar la presencia de grupos lactónicos en la molécula. Actualmente se continúa con la identificación del compuesto activo a través del análisis de sus datos espectroscópicos. ","palabras_clave":"MIKANIA MICRHANTA|TRYPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2916,"idioma_id":4,"titulo":"Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide","resumen":"It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate the effect of chlorpyrifos (CPF) on cell proliferation and the ER&#945;-dependence of this action employing MCF-7 and MDA-MB-231 breast cancer cell lines. We have also analyzed CPF action on the cell cycle distribution and the cyclins that are implicated in G1-S and intra-S checkpoints. Finally, the action on cell death and ROS production were studied. We demonstrated the ability of CPF 0.05&#956;M to induce cell proliferation through ER&#945; in hormone-dependent breast cancer cells. In contrast, CPF 50&#956;M induces intra-S arrest modifying checkpoints proteins, through a mechanism that may involve changes in redox balance in MCF-7. In MDA-MB-231, we have found that CPF 50&#956;M produces an arrest in G2\/M phase which could be related to the capacity of the pesticide for binding to tubulin sites altering microtubules polymerization. Altogether, our results provide new evidences on the action of the pesticide CPF as an environmental breast cancer risk factor due to the effects that causes on the mechanisms that modulate breast cell proliferation.","palabras_clave":"CHLORPYRIFOS|CELL PROLIFERATION|ENDOCRINE DISRUPTORS|BREAST CANCER CELLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2917,"idioma_id":4,"titulo":"Polyaniline nanofibers: Acute toxicity and teratogenic effect on  Rhinella arenarum embryos","resumen":"The fate and effect of nanomaterials in the environment is of paramount importance towards the technological application of the materials. This work shows the ecotoxicological potential of polyaniline(PANI) nanofibers in the larvae Rhinella arenarum by means of AMPHITOX test. Acute toxicity of PANI nanofibers towards embryos of the common South American toad R. arenarum (Anura: bufonidae) was evaluated in the premetamorphosis (stage 25) larvae. The exposure of R. arenarum larvae to at dose of 150, 250 and 400 mg L1 resulted in 100% viability within 96 h exposure. The embryos at 2?4 blastomers stage (early life stage teratogenic test) revealed that embryos were not killed and no teratogenic effects were observed when embryos were incubated with PANI nanofibers (150 and 250 mg L1), while only a growth retardation of embryos was induced at levels of 250 mg PANI nanofibers L1. On the other hand,at 400 mg L1 concentration, a reduction in the body length of larvae and tail malformation was observed. This results suggest that a concentration-dependent toxicity is operative, typified by phenotypes that had abnormal body axes. The presence of PANI nanofibers in gut contents and its excretion by larval stages ofR. arenarum was confirmed by UV?visible spectroscopy.","palabras_clave":"NANOMATERIALS|NANOFIBERS|ECOTOXICOLOGY|AMPHITOX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2918,"idioma_id":5,"titulo":"Estrategias de Enseñanza Virtual en la Facultad de Bioquìmica, Quìmica y Farmacia","resumen":"ESTRATEGIAS DE ENSEÑANZA VIRTUAL EN LA FACULTAD DE BIOQUÍMICA, QUÍMICA Y FARMACIA    Orphèe Cecilia, Cruz Magdalena, Fuentes M. Elena   Facultad de Bioquímica, Química y Farmacia   Tel. 0381-4247752 Int. 7203 corphee@fbqf.unt.edu.ar     En los últimos años, hubo un indudable avance de la tecnología informática y el buen uso de la misma, la transforma en una herramienta de gran utilidad en diversos medios y áreas. El conocimiento y manejo del lenguaje informático de los estudiantes que ingresaron en ésta Facultad a partir del año 2003, es digno de destacar, lo cual resulta ser un beneficio a la hora de repensar estrategias de enseñanza, principalmente en este ámbito educativo.   La Universidad Nacional de Tucumán implementó cursos de Prácticas virtuales para docentes, con características semi presenciales, sobre prácticas de enseñanza-aprendizaje. En base a esta experiencia, se propone la inclusión de prácticas de virtualización en el sistema de enseñanza en las carreras de grado de ésta Facultad, lo cual es un gran reto, ya que se debe contar con una infraestructura apropiada, equipamiento informático, adecuada capacitación de todo el plantel docente, con una apertura y disposición a los nuevos avances tecnológicos para enfrentar estos nuevos desafíos.   La implementación del sistema de tutorías dentro del Proyecto de Mejoramiento de la Enseñanza para las carreras de Farmacia y Bioquímica (PROMFYB), es una herramienta importante para llevar a la práctica ésta nueva estrategia de enseñanza virtual, lo que evitaría el desgranamiento y la deserción del estudiante.   Independientemente del perfil del docente tutor y de la facilidad de realizar las actividades on line, es de suma importancia encontrar el equilibrio justo en la vinculación de la tarea tutorial con su práctica virtual y es aquí donde jugará un rol importante la validación de metodologías alternativas.   La realización de ambas tareas elevará el nivel académico que aspiramos alcanzar.       Palabras claves: tutoría, estrategias, metodologías, virtualizacion, digitalización.","palabras_clave":"VIRTUALIZACIÓN|ESTRATEGIAS|TUTORÍA|METODOLOGÍAS|DIGITALIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2919,"idioma_id":4,"titulo":"Essential Oil of Azorella cryptantha Collected in Two Different Locations from San Juan Province, Argentina: Chemical Variability and Anti-Insect and Antimicrobial Activities","resumen":"Essential oils of two populations of Azorella cryptantha (Clos) Reiche, a native species from San Juan province, were obtained by hydrodistillation in a Clevenger-type apparatus and characterized by GC\/FID and GC\/MS. The compounds identified were 92.3% and 88.7% for A. cryptantha from Bauchaceta and A. cryptantha from Agua Negra respectively. The essential oil composition was similar for both populations with differences in the main components, and in the identity of minor components. The main components of A. cryptantha-BAU essential oil were sabinene (4), betha pinene (5) and delta-cadinol (38) while &#945;-thujene (1), alpha pinene (2), bethe pinene (5) and, delta cadinene (29) were the main monoterpene hydrocarbons in A. cryptantha-AN essential oil wih the addition of 3.0% of oxygenated monoterpenes. Repellent activity on T. infestans nymphs was 100% and 92% for A. cryptantha-AN and A. cryptantha-BAU essential oils respectively. Regarding the toxic effects on C. capitata, the oils were very active with LD50 values of less than 11 µg\/fly. Microsporum gypseum, Trichophyton rubrum and T. mentagrophytes and bacteria LM1-E. coli, LM2-E. coli and PI-Yersinia enterocolitica were more sensitive toward the species collected in Agua Negra (MIC equal 125&#956;g\/ml). This is the first report on the anti-insect and antimicrobial properties of A. cryptantha essential oil and its composition.","palabras_clave":"ESSENTIAL OIL|REPELLENT,|ANTI-INSECT,|ANTIMICROBIAL|AZORELLA CRYPTANTHA."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2920,"idioma_id":4,"titulo":"Dyslipidemia is not associated with cardiovascular disease risk in an animal modelo of mild chronic suboptimal nutrition.","resumen":"Previous studies performed in an experimental model of  nutritional growth retardation (NGR) have      observed metabolic adaptation. We hypothesized that  changes in lipid-lipoprotein profile, glucose, and      insulin levels occur, whereas overall body growth is  reduced.The aim of this study was to assess serum      lipid-lipoprotein profile, hepatogram, insulinemia and  glycemia, and CVD risk markers in rats fed a      suboptimal diet. Weanling male rats were assigned  either to control (C) or NGR group. In this 4-week      study, C rats were fed ad libitum a standard diet, and  NGR rats received 80% of the amount of food      consumed by C. Zoometric parameters, body fat content,  serum lipid-lipoprotein profile, hepatogram,      insulinemia, and glycemia were determined, and the  cardiovascular disease (CVD) risk markers      homeostasis model assessment?insulin resistance and homeostasis model assessment and â-cell       function were calculated. Suboptimal food intake  induced a significant decrease in body weight and      length, which were accompanied by a reduction of 50%  in body fat mass. Serum lipoproteins were      significantly higher in NGR rats, with the exception  of high-density lipoprotein cholesterol, which      remained unchanged. Nutritional growth retardation  rats had decreased triglycerides compared with C      rats. No significant differences were detected in  liver function parameters. The CVD risk markers      homeostasis model assessment (HOMA)?insulin resistance and homeostasis model assessment  and      function were calculated. Suboptimal food intake  induced a significant decrease in body weight and      length, which were accompanied by a reduction of 50%  in body fat mass. Serum lipoproteins were      significantly higher in NGR rats, with the exception  of high-density lipoprotein cholesterol, which      remained unchanged. Nutritional growth retardation  rats had decreased triglycerides compared with C      rats. No significant differences were detected in  liver function parameters. The CVD risk markers      homeostasis model assessment (HOMA)?insulin resistance and homeostasis model assessment  and      function were calculated. Suboptimal food intake  induced a significant decrease in body weight and      length, which were accompanied by a reduction of 50%  in body fat mass. Serum lipoproteins were      significantly higher in NGR rats, with the exception of  high-density lipoprotein cholesterol, which      remained unchanged. Nutritional growth retardation  rats had decreased triglycerides compared with C      rats. No significant differences were detected in  liver function parameters. The CVD risk markers      homeostasis model assessment (HOMA)?insulin resistance and homeostasis model assessment  and      function were calculated. Suboptimal food intake  induced a significant decrease in body weight and      length, which were accompanied by a reduction of 50%  in body fat mass. Serum lipoproteins were      significantly higher in NGR rats, with the exception  of high-density lipoprotein cholesterol, which      remained unchanged. Nutritional growth retardation  rats had decreased triglycerides compared with C      rats. No significant differences were detected in  liver function parameters. The CVD risk markers      homeostasis model assessment (HOMA)?insulin resistance and homeostasis model assessment  and      function were calculated. Suboptimal food intake  induced a significant decrease in body weight and      length, which were accompanied by a reduction of 50%  in body fat mass. Serum lipoproteins were      significantly higher in NGR rats, with the exception  of high-density lipoprotein cholesterol, which      remained unchanged.  Nutritional growth retardation rats had decreased triglycerides compared with C      rats. No significant  differences were detected in liver function parameters. The CVD risk markers      homeostasis model  assessment (HOMA)?insulin resistance and  homeostasis model assessment and      function were  calculated. Suboptimal food intake induced a significant decrease in body  weight and      length, which were  accompanied by a reduction of 50% in body fat mass. Serum lipoproteins were      significantly higher  in NGR rats, with the exception of high-density lipoprotein cholesterol, which      remained unchanged.  Nutritional growth retardation rats had decreased triglycerides compared with C      rats. No significant  differences were detected in liver function parameters. The CVD risk markers      homeostasis model  assessment (HOMA)?insulin resistance and  homeostasis model assessment and      function were  calculated. Suboptimal food intake induced a significant decrease in body  weight and      length, which were  accompanied by a reduction of 50% in body fat mass. Serum lipoproteins were      significantly higher  in NGR rats, with the exception of high-density lipoprotein cholesterol, which      remained unchanged.  Nutritional growth retardation rats had decreased triglycerides compared with C      rats. No significant  differences were detected in liver function parameters. The CVD risk markers      homeostasis model  assessment (HOMA)?insulin resistance and  homeostasis model assessment and      ?insulin resistance and  homeostasis model assessment and â-cell       function were  calculated. Suboptimal food intake induced a significant decrease in body  weight and      length, which were  accompanied by a reduction of 50% in body fat mass. Serum lipoproteins were      significantly higher  in NGR rats, with the exception of high-density lipoprotein cholesterol, which      remained unchanged.  Nutritional growth retardation rats had decreased triglycerides compared with C      rats. No significant  differences were detected in liver function parameters. The CVD risk markers      homeostasis model  assessment (HOMA)?insulin resistance and  homeostasis model assessment and      ?insulin resistance and  homeostasis model assessment and       â-cell function were  significantly lower in NGR rats. Mild chronic suboptimal nutrition in weanling       male rats led to  growth retardation and changes in the lipid-lipoprotein profile, glucose, and  insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal food  intake, which ensures substrates flux to tissues that require constant energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction of      approximately  20% could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic adaptation  during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      male rats  led to growth retardation and changes in the lipid-lipoprotein profile,  glucose, and insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal  food intake, which ensures substrates flux to tissues that require constant  energy?in       detriment to body  growth. The CVD risk markers suggested that mild chronic food restriction of      approximately 20%  could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      detriment to  body growth. The CVD risk markers suggested that mild chronic food restriction  of      approximately  20% could provide protection against this degenerative disease.      -cell  function were significantly lower in NGR rats. Mild chronic suboptimal  nutrition in weanling       male rats led to  growth retardation and changes in the lipid-lipoprotein profile, glucose, and  insulin      levels while  preserving the integrity of liver function. These data suggest a metabolic  adaptation during      suboptimal food  intake, which ensures substrates flux to tissues that require constant energy?in       detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      ?in       detriment to body growth. The CVD risk markers  suggested that mild chronic food restriction of      approximately 20% could provide protection against  this degenerative disease.      &nbsp;","palabras_clave":"SUBOPTIMAL NUTRITION|NUTRITION GROWTH RETARDATION|LIPID LIPOPROTEIN PROFILE|LIVER FUNCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2921,"idioma_id":4,"titulo":"Influence of fish oil in the concentration of conjugated linoleic acid and omega 6 and 3 in buffalo milk","resumen":"The aim of this research work was to investigate the influence of fish oil supplementation on the concentration of conjugated linoleic acid (CLA) and omega 6 and 3 in samples of buffalo milk. A total of 24 female buffaloes separated at random into three groups were fed for 49 days with: natural pasture (group I), supplemented with 70mL of fish oil (group II) and 140mL of fish oil (group III). In the experiment the concentration of CLA showed differences (P<0.05) among the three groups, with a maximum of 7.14mg\/g fat in group II. No significant differences were found in omega-6 among the three groups. The highest value of 3.82mg\/g fat corresponded to group I, whicht had not been supplemented with fish oil. Significant differences were observed in omega 3 (P<0.05) in groups II and III with respect to group I. The highest average value of 2.42mg\/g fat was obtained in group III. The closest relationship omega 6\/3 (1.37:1) was observed in group III. As a result, the diets of groups II and III, which included fish oil, increased significantly the content of CLA and omega 3 with reductions in levels of omega 6.","palabras_clave":"BUBALUS|MILK|CLA|OMEGA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2980,"idioma_id":5,"titulo":"Sistema previsional de la República de Madagascar","resumen":"Se describe el funcionamiento del Sistema previsional de la República de Benín, con el fin de analizar los desafíos que deberá enfrentar este sistema a fin de ser viable a futuro.","palabras_clave":"Sistema|Previsional"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2988,"idioma_id":5,"titulo":"Nuevo registro de Notofenusa surosa (Konow, 1905) (Hymenoptera: Tenthredinidae)  para la Patagonia norte de Argentina.","resumen":"El género Notofenusa fue descripto por primera vez en el año 1959 para Argentina y Chile. Posteriormente, en 1973 se confirma la presencia de N. surosaasociada a los bosques de Nothofagus.El objetivo de esta nota es brindar información sobre las características que permitieron su identificación y sobre aspectos ecológicos relacionados con su hábito como insecto minador. La identificación de estos ejemplares fue realizada mediante claves taxonómicas con el apoyo de fotografías de microscopio electrónico de barrido.","palabras_clave":"eaf-mining insect|Nothofagaceae|sawfly"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2996,"idioma_id":5,"titulo":"Dinámica social y territorial en relación a problemáticas del uso del agua. Estudio a nivel de cuencas en la vertiende oriental de las Sierras Chicas","resumen":"El artículo tiene como finalidad mostrar avances, reflexiones y resultados alcanzados hasta el momento, en torno a una investigación que trabaja la problemática del agua en las Sierras Chicas. El proyecto se realiza en el marco del Departamento de Geografía de la FFyH, con subsidio de SECyT, desde el año 2008.   Las localidades ubicadas en el faldeo oriental de las Sierras Chicas, sufren cíclicamente crisis por la insuficiencia hídrica. Este escenario plantea disputas por el recurso y situaciones conflictivas entre los diversos agentes sociales.   Se trabajan las cuencas como territorio y, en este sentido, se pretende dar un giro a las tradicionales líneas de trabajo  que  limitan el conflicto del  agua a una visión lineal aportando soluciones técnicas. En base a ello, lo que se indaga, son las continuidades entre el orden de la prácticas particulares respecto al agua, situadas socio-espacio-temporalmente, como  modo de vincular aquella solución tecnocrática y la práctica posible y razonable, en busca de la solución eficaz y factible.","palabras_clave":"recursos hídricos|territorio|vertiente oriental sierras chicas|gestión social del agua"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":2999,"idioma_id":4,"titulo":"Search for charged Higgs bosons through the violation of lepton universality in $t\\bar{t}$ events using $pp$ collision data at $\\sqrt{s}=7$ TeV with the ATLAS experiment","resumen":" In several extensions of the Standard Model, the top quark can decay into a bottom quark and a light charged Higgs boson H (+), t&#8201;&#8594;&#8201;bH (+), in addition to the Standard Model decay t&#8201;&#8594;&#8201;bW. Since W bosons decay to the three lepton generations equally, while H (+) maypredominantlydecayinto &#964;&#957;, charged Higgs bosons can be searched for using the violation of lepton universality in top quark decays. The analysis in this paper is based on 4.6 fb(&#8722;1) of proton-proton collision data at TeV collected by the ATLAS experiment at the Large Hadron Collider. Signatures containing leptons (e or &#956;) and\/or a hadronically decaying &#964; (&#964; (had)) are used. Event yield ratios between e + &#964; (had) and e + &#956;, as well as between &#956; + &#964; (had) and&#956; + e, final states are measured in the data and compared to predictions from simulations. This ratio-based method reduces the impact of systematic uncertainties in the analysis. No significant deviation from the Standard Model predictions is observed. With the assumption that the branching fraction (H (+)&#8201;&#8594;&#8201;&#964;&#957;) is 100%, upper limits in the range 3.2%\u20134.4% can be placed on the branching fraction (t&#8201;&#8594;&#8201;bH (+)) for charged Higgs boson masses m ( )H(+) in the range 90\u2013140 GeV. After combination with results from a search for charged Higgs bosons in decays using the &#964; (had) + jets final state, upper limits on (t&#8201;&#8594;&#8201;bH (+)) can be set in the range 0.8%\u20133.4%, for m ( )H(+) in the range 90-160 GeV.In several extensions of the Standard Model, the top quark can decay into a bottom quark and a light charged Higgs boson H+, t to bH+, in addition to the Standard Model decay t to bW. Since W bosons decay to the three lepton generations equally, while H+ may predominantly decay into tau+nu, charged Higgs bosons can be searched for using the violation of lepton universality in top quark decays. The analysis in this paper is based on 4.6\/fb of proton-proton collision data at sqrt(s) = 7 TeV collected by the ATLAS experiment at the Large Hadron Collider. Signatures containing leptons (e or mu) and\/or a hadronically decaying tau (tau_had) are used. Event yield ratios between e+tau_had and e+mu, as well as between mu+tau_had and mu+e, final states are measured in the data and compared to predictions from simulations. This ratio-based method reduces the impact of systematic uncertainties in the analysis. No significant deviation from the Standard Model predictions is observed. With the assumption that the branching fraction B(H+ to tau+nu) is 100%, upper limits in the range 3.2%-4.4% can be placed on the branching fraction B(t to bH+) for charged Higgs boson masses m(H+) in the range 90-140 GeV. After combination with results from a search for charged Higgs bosons in ttbar decays using the tau_had+jets final state, upper limits on B(t to bH+) can be set in the range 0.8%-3.4%, for m(H+) in the range 90-160 GeV.","palabras_clave":"ATLAS|High|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3000,"idioma_id":4,"titulo":"Search for contact interactions and large extra dimensions in dilepton events from pp collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":" A search for non-resonant new phenomena, originating from either contact interactions or large extra spatial dimensions, has been carried out using events with two isolated electrons or muons. These events, produced at the LHC in proton-proton collisions at sqrt(s) = 7 TeV, were recorded by the ATLAS detector. The data sample, collected throughout 2011, corresponds to an integrated luminosity of 4.9 and 5.0 fb-1 in the e+e- and mu+mu- channels, respectively. No significant deviations from the Standard Model expectation are observed. Using a Bayesian approach, 95% confidence limit lower limits ranging from 9.0 to 13.9 TeV are placed on the energy scale of llqq contact interactions in the left-left isoscalar model. Lower limits ranging from 2.4 to 3.9 TeV are also set on the string scale in large extra dimension models. After combination of these limits with results from a similar search in the diphoton channel, slightly more stringent limits are obtained.","palabras_clave":"ATLAS|high"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3001,"idioma_id":4,"titulo":"Quaternary volcanic sedimentary sequences and evolution of the Llancanelo Lake region (Southern Mendoza, Western Argentina) evidenced from geoelectric methods","resumen":"Llancanelo Lake region (SouthernMendoza Province,Western Argentina) is a key area for investigating theregional evolution of a tectonic basin affected by intense arc- and back-arc volcanism. However, the lack ofenough outcrops makes it difficult to perform such reconstructions. In order to solve this problem, and with the aim of depicting the subsurface stratigraphy, 22 geoelectric surveys reaching more than 100 m depthwere performed. The applied methodology, that combined geoelectrical measurements and field observations, is a continuation of previous works carried out in the region, and allowed for the first time to establish a near-surface stratigraphy that records the last evolutive stages of the lake. establish a near-surface stratigraphy that records the last evolutive stages of the lake. is a continuation of previous works carried out in the region, and allowed for the first time to establish a near-surface stratigraphy that records the last evolutive stages of the lake. establish a near-surface stratigraphy that records the last evolutive stages of the lake. the aim of depicting the subsurface stratigraphy, 22 geoelectric surveys reaching more than 100 m depthwere performed. The applied methodology, that combined geoelectrical measurements and field observations, is a continuation of previous works carried out in the region, and allowed for the first time to establish a near-surface stratigraphy that records the last evolutive stages of the lake. establish a near-surface stratigraphy that records the last evolutive stages of the lake. is a continuation of previous works carried out in the region, and allowed for the first time to establish a near-surface stratigraphy that records the last evolutive stages of the lake. establish a near-surface stratigraphy that records the last evolutive stages of the lake. ","palabras_clave":"geoelectrica|geologia lacustre"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3002,"idioma_id":5,"titulo":"El análisis de información financiera en las actividades agrícolas","resumen":"El trabajo plantea las diferencias en el análisis de información financiera cuando la misma comprende a las actividades ganaderas.Planteando, a criterio del autor, la interpretación que debería realizarse en cada caso.","palabras_clave":"GANADERÍA|ANÁLISIS DE ESTADOS FINANCIEROS|FINANZAS|RENTABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3005,"idioma_id":4,"titulo":"Glomerella leaf spot caused by a non-homothallic strain of Glomerella cingulata on highbush blueberry nursery plants in Buenos Aires, Argentina.","resumen":"In February 2009, irregular-shaped leaf spots affected blueberry (Vaccinium corymbosum L. ?Blue Crisp?, ?Misty?, and ?Sharp Blue?) nursery plants in Buenos Aires. Single-spore cultures on potato dextrose agar and oat agar showed aerial white mycelium that turned light and dark gray, dark brown acervuli with setae, and a salmon-to-orange conidial mass. Septate, dark brown, 62 to 78 &#956;m long setae were abundant in the acervulus. Conidia were unicellular, hyaline, straight, cylindrical, round at the ends, and averaged 15.2 (12.1 to 16.9) × 5.4 (4.9 to 6.2) &#956;m. Dark brown, ovate to clavate, 10.25 × 6.25 &#956;m (9 to 12 × 5 to 8) appressoria with a noticeable pore formed on slides near the edge of the cover glass. Dark subglobose structures were recorded immersed in the culture medium. No asci or ascospores were observed, indicating a nonhomothallic condition. The fungus was identified as Colletotrichum gloeosporioides (Penz.) Penz & Sacc. (teleomorph Glomerella cingulata (Stoneman) Spauld. & H. Schrenk) with traits similar to those already described (1). DNA was obtained from mycelium with a standard DNA extraction kit and the ribosomal, internal transcribed spacer (ITS) 1 and ITS2 regions were PCR amplified and sequenced with primers ITS1 and ITS4 (2). A BLASTN algorithm search revealed 100% identity of the sequence (535 bp long) with G. cingulata\/C. gloeosporioides from citrus and mango and one from coffee identified as C. kahawae (GenBank Accession No. JF908919). The nucleotide sequence was deposited in GenBank (Accession No. JQ340087). Pathogenicity was verified on Young plants and detached leaves of highbush blueberry ?Emerald?, ?Misty?, ?O´Neal?, and ?Santa Fe?, olive (Olea europaea ?Arbequina?), and marketed fruits of apple, mango, orange, and tomato. Disinfected healthy leaves were inoculated with a 9-mm2 mycelial block and incubated at 24°C with 12 h of light. Young plants were infected by placing the disinfected end of the branches within a micropipette tip filled with mycelium and kept under greenhouse conditions. Asymptomatic fruits of apple, mango, orange, and tomato were inoculated by placing a mycelial block on a small wound made on their surface. Detached leaves of highbush blueberry ?Emerald?, ?O´Neal?, ?Misty?, and ?Santa Fe? showed 0.1 to 1.5 × 0.8 to 2 cm necrotic lesions after 3 days, covering 43 to 100% of the ?Emerald? leaf area after 8 days. Young plants of blueberry ?Emerald? and ?Misty? showed 1.5 to 3 cm necrotic lesions, acervuli, a salmon-orange conidial mass, and death of leaves at 25 days. On olive ?Arbequina?, leaf necrotic lesions reached 0.1 to 3.5 cm after 5 days. Symptoms developed slowly on infected tomato fruits while inoculated fruits of apple, mango, and orange showed dark brown lesions that measured 2 to 7 × 1 to 3.5 cm at 5 days. No symptoms were observed on controls. The fungus was reisolated from inoculated plant parts. The disease was previously cited in Argentina (3), but to our knowledge, this is the first report of a nonhomothallic strain of G. cingulata from highbush blueberry colonizing and deteriorating fruits of apple, mango, orange, and tomato","palabras_clave":"FUNGI|PLANT FUNGI|VACCINIUM CORYMBOSUM|FRUIT CROPS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3006,"idioma_id":4,"titulo":"Efficient wheat germ agglutinin purification with a chitosan-based affinity chromatographic matrix","resumen":"An efficient affinity chromatographic matrix based on chitosan for wheat germ agglutinin (WGA) purification was developed. The matrices assayed consisted of chitosan mini-spheres cross-linked with epichlorhydrin 45, 250 or 500 mM. The maximum adsorption capacity of pure WGA - calculated from the corresponding isotherms - was between 43.2 and 48.9 mg\/g at pH 5.0 and between 16.6 and 27.6 mg\/g at pH 8.5. However, the adsorption of WGA from wheat germ extract was higher at pH 8.5. In addition, 0.5 g of mini-spheres cross-linked with epichlorhydrin 250 mM adsorbed 94.5% of the WGA present in 5 mL of the concentrated extract. Acetic acid was able to elute 100% of the adsorbed WGA. The purity of the WGA obtained was greater than 95% and the purification factor was 56.8. The matrix was able to have the same performance of the purification process for three consecutive cycles. A new method to monitor the purification process by RP-HPLC was developed.","palabras_clave":"WHEAT GERM AGGLUTININ|PURIFICATION|CHITOSAN|AFFINITY CHROMATOGRAPHIC MATRIX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3007,"idioma_id":4,"titulo":"Effect of 1-MCP on the expression of chlorophyll degrading genes during senescence of broccoli (Brassica oleracea L.)","resumen":"Degreening caused by chlorophylldegradation is the most evident visual manifestation of broccoli senescence anddeterioration. In this work, the effect of 1-MCP on color change, chlorophylldegradation and expression of genes associated to chlorophyll catabolism wasevaluated during postharvest storage. 1-MCP treatment markedly delayed degreeningand reduction of chlorophyll content. The expression of genes encodingchlorophyllases showed different behaviors. In controls, theexpression of BoCLH1 decreased duringpostharvest storage while that of BoCLH2increased after 72 h and then decreased. The treatment with 1-MCP did not causeany effect on BoCLH1 but induced ahigher expression of BoCLH2. Ahigh BoPPH expression level was foundin senescent broccoli &#64258;orets, but the up-regulation of this gene was delayed by1-MCP treatment. The expression of BoPaO, a geneencoding a pheophorbide a oxygenase, increased after three days and thendecreased. In contrast, this expression was reduced in treated broccoli.Finally, the expression of BoRCCR decreasedduring senescence and the treatment with 1-MCP caused a higher decrement. Theseresults show that postharvest 1-MCP inhibit selectively some of the genesencoding enzymes related chlorophyll catabolism. ","palabras_clave":"BROCCOLI|POSTHARVEST|SENESCENCE|1-MCP|CHLOROPHYLL CATABOLIC ENZYME"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3008,"idioma_id":4,"titulo":"Validation and field evaluation of a competitive enzyme-linked immunosorbent assay for diagnosis of Babesia bovis infections in Argentina","resumen":"Infections by Babesia bovis limit cattle production and cause important economic losses in tropical and subtropical areasaround the world. Monitoring of calf sera can be used to detect unprotected cattle herds and to decide on strategic control measures, as well as for epidemiological studies. Merozoite surface antigen 2c (MSA-2c) is an immunodominant surface protein expressed in B. bovis merozoites and sporozoites and contains B-cell epitopes that are conserved among geographic isolates. A monoclonal antibody against recombinant MSA-2c (rMSA-2c) was previously shown to inhibit the binding of anti-B. bovis antibodies to a parasite B-cell epitope in a competitive enzyme-linked immunosorbent assay (cELISA) format. In the work at hand, the parameters of this cELISA were reevaluated and adjusted when necessary, and a cutoff value was determined by receiver operator characteristic (ROC) curve analysis of a total of 357 bovine sera of known reactivity, as assessed by indirect immunofluorescence assay (IFAT). The established rMSA-2c cELISA demonstrated a specificity of 98% and a sensitivity of 96.2%. An additional set of 303 field bovine sera from regions where ticks are endemic and tick-free regions of Argentina was tested by both rMSA-2c cELISA and IFAT, and the results were shown to be in very good agreement (kappa index, 0.8325). The performance shown by rMSA-2c cELISA in the detection of B. bovis-specific antibodies and its suitability for&nbsp; standardization and large-scale production, as well as the possibility of its application in most veterinary diagnostic laboratories, make the assay a powerful tool for the surveillance of herd immunity as a strategic measure for the control of bovine babesiosis.Babesia bovis limit cattle production and cause important economic losses in tropical and subtropical areasaround the world. Monitoring of calf sera can be used to detect unprotected cattle herds and to decide on strategic control measures, as well as for epidemiological studies. Merozoite surface antigen 2c (MSA-2c) is an immunodominant surface protein expressed in B. bovis merozoites and sporozoites and contains B-cell epitopes that are conserved among geographic isolates. A monoclonal antibody against recombinant MSA-2c (rMSA-2c) was previously shown to inhibit the binding of anti-B. bovis antibodies to a parasite B-cell epitope in a competitive enzyme-linked immunosorbent assay (cELISA) format. In the work at hand, the parameters of this cELISA were reevaluated and adjusted when necessary, and a cutoff value was determined by receiver operator characteristic (ROC) curve analysis of a total of 357 bovine sera of known reactivity, as assessed by indirect immunofluorescence assay (IFAT). The established rMSA-2c cELISA demonstrated a specificity of 98% and a sensitivity of 96.2%. An additional set of 303 field bovine sera from regions where ticks are endemic and tick-free regions of Argentina was tested by both rMSA-2c cELISA and IFAT, and the results were shown to be in very good agreement (kappa index, 0.8325). The performance shown by rMSA-2c cELISA in the detection of B. bovis-specific antibodies and its suitability for&nbsp; standardization and large-scale production, as well as the possibility of its application in most veterinary diagnostic laboratories, make the assay a powerful tool for the surveillance of herd immunity as a strategic measure for the control of bovine babesiosis.","palabras_clave":"Babesia bovis|Competitive Enzyme-Linked Immunosorben Assay|MSA2-c|Diagnosis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3009,"idioma_id":4,"titulo":"Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the &#948;-lactone ring    in determining differentiation-inducing potency and selective pro- apoptotic action","resumen":"Previous studies indicated the need of at least one phenolic hydroxyl   group in the coumarin core for induction of cytotoxicity in different   cell lines. Herein, we present an exhaustive structure-activity   relationship study including ortho-dihydroxycoumarins (o-DHC)   derivatives, cinnamic acid derivatives (as open-chain coumarin   analogues) and 1,2-pyrones (representative of the &#948;-lactone ring of the   coumarin core), carried out to further identify the structural features   of o-DHC required to induce leukemic cell differentiation and   apoptosis in U-937 cells. Our results show for the first time that the   &#948;-lactone ring positively influences the aforementioned biological   effects, by conferring greater potency to compounds with an intact   coumarin nucleus. Most tellingly, we reveal herein the crucial role of   this molecular portion in determining the selective toxicity that o-DHC show for leukemic cells over normal blood cells. From a pharmacological perspective, our findings point out that o-DHC may be useful prototypes for the development of novel chemotherapeutic agents.","palabras_clave":"APOPTOSIS|LEUKEMIA|COUMARIN|DIFFERENTIATIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3010,"idioma_id":4,"titulo":"Synthesis and characterization of pure-phase La0.75Sr0.25Cr0.5Mn0.5O3&#8722;&#948; nanocrystallites for solid oxide fuel cell applications","resumen":"Nanopowders of La0.75Sr0.25Cr0.5Mn0.5O3-d (LSCM) perovskite-type oxide, potential electrode  material for symmetrical solid oxide fuel cell  (S-SOFC), have been successfully prepared by the  solution combustion method employing glycine as  complexing agent and fuel. Several glycine-to-nitrates  molar ratios were investigated. A detailed morphological  and structural characterization was performed,  employing X-ray diffraction, N2 physisorption, and  electron microscopy (scanning and transmission). The  as-synthesized LSCM nanopowders consist of interconnected  nanoparticles forming a sponge-like structure  with typical meso- and macropores. For glycineto-  nitrates molar ratios above stoichiometric molar  ratio, a high proportion of well-crystallized LSCM  phase was obtained. An increase of glycine content in  the initial synthesis gel, decreases the average nanoparticles  size from 20 to 6 nm, narrows the  distribution crystallite size, and increases the specific  surface area of the LSCM nanopowders from 14 to  30 m2\/g. The evolution of crystalline phases of the  as-synthesized LSCM nanopowders after calcination  at various temperatures was studied: pure-phase  La0.75Sr0.25Cr0.5Mn0.5O3-d perovskites with particlesize  distribution between 100 and 300 nm, have been  obtained after calcination at 1,000 C for 6 h. The  crystalline structural analyses showed that the LSCM  nanocrystallites have trigonal\/rhombohedral symmetry  in the R-3c space group. These final LSCM  nanopowders present microstructures with low densification  and open porosity but probably with sufficient  integrity to enable them to be used as efficient  electrodes in S-SOFC.","palabras_clave":"LSCM|COMBUSTION|NANOPARTICLES|ELECTRODES|S-SOFC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3011,"idioma_id":4,"titulo":"Molecular cytogenetic studies of the 'Xanthocephalum group' (Asteraceae)","resumen":"Fourteen North American members of the ?? Xanthocephalum group?? were studied by classical and molecular cytogenetics. Location and number of rDNA sites were determined by FISH. For the 5S rDNA, a probe was obtained from Prionopsis ciliata. Most species were diploid (2n = 12), although Isocoma menziesii, Grindelia hirsutula, G. robusta, both varieties of G. stricta, and one population of G. camporum were tetraploid (2n = 24).  Diploid Grindelia and Prionopsis ciliata were 5m +1sm, tetraploids 10m + 2sm, except G. hirsutula (8m + 4sm),and Isocoma and Olivaea 6m ? 2sm and 3m + 3sm,respectively. Most species had satellites on the short arms  of m pairs: two in tetraploids and P. ciliata and one in diploids. Satellites were associated with two CMA+\/DAPI- bands in diploid species and four bands in tetraploids and in P. ciliata. rDNA loci (two in diploids to four in tetraploids) may be indicative of ploidy level. Grindelia tetraploids could have originated recently by autopolyploidy.  Chromosome duplication was followed by modi&#64257;cations in the genome structure, resulting in higher heterochromatin amounts not associated with NORs. There is only one 5S site per basic genome in para or pericentromeric regions. Although not always large, chromosome  variation has accompanied the evolutionary divergence of the taxa studied","palabras_clave":"18-5.8-26S and 5S rDNA |Asteraceae |Fluorescent banding |Karyotypes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3012,"idioma_id":4,"titulo":"Towards a rational strategy for monitoring of microbiological quality of ambient waters","resumen":"Water is one of the main sources of human exposure to microbiological hazards.Although legislation establishes regulatory standards in terms of fecal indicator bacteria to assess the microbiological quality of water, these do not necessarily predict the presence of pathogens such as parasites and viruses. Better surveillance and management strategies are needed to assess the risk of pathogens waterborne transmission.  We established a baseline dataset to characterize river water quality, identify changes over time, and design a rational monitoring strategy. Data from a year-long monthly monitoring campaign of the polluted Arenales River (Argentina), were analyzed to statistically correlate physicochemical and microbiological variables, the seasonal and  longitudinal variation of the water quality and determine the similarity between study sites. The measured variables (sixteen) reflected the deterioration in the river quality through the city. Different viruses and parasites found did not correlate with the concentration of total and thermotolerant coliforms. There was significant seasonal variation for temperature, turbidity, conductivity, dissolved oxygen, enterococci, and  norovirus. Strong correlations between some variables were found; we selected eight variables (dissolved oxygen, conductivity, turbidity, total and thermotolerant coliforms, Enterococcus, and adenovirus and Microsporidium as viral and parasitological indicators, respectively) for future monitoring. There was similarity between the monitoring locations, which were grouped into four clusters validated by cophenetic correlation and supported by discriminant analysis. This allowed us to reduce the number of sites, from eleven down to five. Sixty seven percent of the total variance and the correlation structure between variables was explained using five principal components. All these analyses ledto a new long-term systematic monitoring scheme A rational monitoring strategy based on the selection of the most suitable monitoring points and of the most significant variables to measure, will result in optimal use of the limited resources available to adequately protect public and environmental health.","palabras_clave":"WATER QUALITY|ENTERIC VIRUS|PARASITE|MICROBIAL INDICATOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3013,"idioma_id":4,"titulo":"From coexistence to competitive exclusion: can overfishing change the outcome of competition in skates (Chondrichthyes, Rajidae)?","resumen":"Competition for food could be a major force driving changes in the community structure of skates (Rajidae) subjected to fishing exploitation. Under this hypothesis, small skates are released fromcompetition with larger skates after fishing has depleted the larger species. Here, we compare the abundance patterns of two sympatric skates with similar niches but different life histories, Bathyraja albomaculata (larger and slow-reproducing) and Bathyraja macloviana (smaller and faster-reproducing), before (1971, 1978) and after (1998-2004) a 108% increase in industrial bottom trawling on the southeastern South American shelf in order to test the prediction that B. macloviana should  competitively exclude B. albomaculata after the increase in fishing mortality. In 1971 and 1978, there was no relationship between the abundance of both species, indicating that they coexisted over large scales. In 1998-2004, the relationship between the abundances ofthese skates was bell-shaped, indicating that both species increased in abundance at low densities until peaking, after which B. albomaculata decreased when B. macloviana became more abundant, consistent withresource competition. We tested whether food may be a potential limiting  resource by comparing the diet of both species. The two species consumed mostly polychaetes, differing only in the consumption of polychaetesfrom the family Nephthyidae, which was much higher for B. macloviana. Bathyraja macloviana could replace B. albomaculata at high densities when food resources may become scarce. These results support the hypothesis that competition release is an important factor explaining the changes in skate communities in overexploited areas.","palabras_clave":"DIET OVERLAP|RESOURCE COMPETITION|FISHERIES|FEEDING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3014,"idioma_id":4,"titulo":"Antitumor Protection by NGcGM3\/VSSP Vaccine Against Transfected B16 Mouse Melanona Cells Overexpressing N-Glycolylated gangliosides","resumen":"Background: Cancer vaccines are designed to  modulate immunological responses against tumor cells through  the presentation of tumor antigens. Materials and Methods: The  mouse mRNA of the cytidine monophospho-N-acetylneuraminic  acid hydroxylase (Cmah) gene, the enzyme that catalyzes the  synthesis of N-glycolylneuraminic acid (NGc), was cloned and  transfected into the B16 melanoma cell line. Transfected cells  (B16-H) were characterized and used as an NGcGM3-positive  primary tumor model for the evaluation of the therapeutic  activity of the NGcGM3\/VSSP vaccine. Results: The presence  of NGcGM3 in B16-H cells promoted proliferation and  adhesion in vitro, but resulted in reduced tumorigenicity in vivo.  However, B16-H cells developed growing tumors in mice where  NGcGM3\/VSSP vaccination induced a therapeutic antitumor  activity. NGcGM3\/VSSP was ineffective in mice inoculated with  parental B16 or B16-H cells that had lost NGcGM3 expression.  Conclusion: The presence of NGcGM3 in tumor cells is critical  for the antitumor activity of NGcGM3\/VSSP vaccine.","palabras_clave":"SIALIC ACID|N-GLYCOLYLATED GANGLIOSIDES|CYTIDINE MONOPHOSPHO-N-ACETYLNEURAMINIC HYDROXYLASE|CANCER|IMMUNOTHERAPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3015,"idioma_id":4,"titulo":"Physicochemical, thermal and sorption properties of nutritionally differentiated flours and starches","resumen":"The aims of this work were to analyze physicochemical and thermal properties of ahipa and cassava flours and starches and to determine their water sorption isotherms and thermodynamic properties. Both flours are naturally gluten-free products, obtained by relatively simple procedures (grating or slicing). Ahipa flour gelatinized at lower temperature than cassava, indicating a better aptitude for cooking. Gelatinization temperatures of flours were higher than those of their starches. Water holding capacity of ahipa flours was significantly higher than those of cassava, leading the slicing process the highest values. Sorption isotherms were determined at 10, 20 and 30ºC.  Experimental data were satisfactorily fitted using different mathematical models.  21 Thermodynamic parameters associated with water adsorption process were calculated  22 from GAB model, as well as the monolayer water content. All samples could be  23 considered as products with an acceptable stability.","palabras_clave":"Flour and starch stability|Thermal behavior|Physicochemical properties|Water sorption process|Thermodynamic properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3016,"idioma_id":4,"titulo":"beta-casein hydrolysate generated by the cell envelope-associated proteinase of Lactobacillus delbrueckii subsp lactis CRL 581 protects against trinitrobenzene sulfonic acid induced colitis in mice","resumen":"Lactobacillus delbrueckii ssp. lactis CRL 581, a thermophilic lactic acid bacterium used as a starter culture for the manufacture of several fermented dairy products, possesses an efficient proteolytic system that is able to release a series of potentially bioactive peptides (i.e., antihypertensive and phosphopeptides) from alpha- and beta-caseins. Considering the potential beneficial health effects of the peptides released by L. delbrueckii ssp. lactis CRL 581 from milk proteins, the aim of this work was to analyze the anti-mutagenic and antiinflammatory properties of the casein hydrolysates generated by the cell envelope-associated proteinase of this bacterium. The ability of alpha and beta-casein hydrolysates to suppress the mutagenesis of a direct-acting mutagen 4-nitroquinoline-N-oxide on Salmonella typhimurium TA 98 and TA 100 increased concomitantly with the time of casein hydrolysis. The anti-inflammatory effect of thebeta-casein hydrolysate was evaluated using a trinitrobenzene sulfonic acid (TNBS)-induced Crohn?s disease murine model. The hydrolysate was administered to mice 10 d before the intrarectal inoculation of TNBS. The mice that received beta-casein hydrolysate previously to TNBS showed decreased mortality rates, faster recovery of initial body weight loss, less microbial translocation to the liver, decreased beta-glucuronidase and myeloperoxidase activities in the gut, and decreased colonic macroscopic and microscopic damage compared with the animals that did not receive this hydrolysate. In addition, beta-casein hydrolysate exerted a beneficial effect on acute intestinal inflammation by increased interleukin 10 and decreased IFN-gamma production in the gut. Our findings demonstrated the healthpromoting attributes of the milk products fermented by L. delbrueckii ssp. lactis CRL 581 and open up new opportunities for developing novel functional foods.&nbsp;","palabras_clave":"BIOACTIVE PEPTIDE|LACTIC ACID BACTERIA|CASEIN HYDROLYSATE|PROTEINASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3018,"idioma_id":4,"titulo":"Rheological, functional and nutritional properties of wheat\/broad bean (Vicia faba) flour blends for pasta formulation","resumen":"Bread wheat flour was substituted with broad bean (Vicia faba)   flour in order to obtain nutritionally enhanced spaghetti evaluated by a   chemical score. Three substitution levels were tested: 10%, 20% and 30%   and the farinographic behavior of blends were analyzed. Spaghetti-type   pasta was made using a Brabender extruder with a non-compression screw   and a nozzle with three 1.5&nbsp;mm diameter holes. A temperature of 40&nbsp;°C   and a speed of 60&nbsp;rpm were applied. The cooked spaghetti were assessed   for this physical\u2013chemical behavior, firmness and stickiness as traits   of quality. The farinograph mixing curve showed a rise in water   absorption and a decrease in dough development time with greater   weakening, when the substitution level increases. The resulting pasta   presented acceptable cooking characteristics and sensory attributes, as   well as a significant improvement in their protein content and quality.   The addition of 30% of broad bean flour contributes to an important   increase in the nutritional quality of the spaghetti without affecting   their texture, flavor or physical\u2013chemical properties.","palabras_clave":"COMPOSITE FLOURS|WHEAT|BROAD BEANS (VICIA FABA)| SPAGHETTI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3019,"idioma_id":4,"titulo":"Thermodynamic and structural analysis of homodimeric proteins: model of &#946;&#8722;lactoglobulin","resumen":"The energetics  of protein homo-oligomerization was analyzed in detail with the application of a general thermodynamic model.  We have studied the thermodynamic aspects of protein-protein interaction employing  &#61538;-lactoglobulin A from bovine milk at pH=6.7 where the protein is mainly in its dimeric form. We performed differential calorimetric scans at different total protein concentration and the resulting thermograms   were analyzed with the thermodynamic model for oligomeric proteins previously developed. The thermodynamic model employed,allowed the prediction of the sign of the enthalpy of dimerization,the analysis of complex calorimetric profiles without transitions baselines subtraction and the obtainment of the thermodynamic parameters from the unfolding and the association processes  and the compared with association parameters   obtained with Isothermal Titration Calorimetry performed at different temperatures. The dissociation and unfolding reactions were also monitored by Fourier-transform infrared spectroscopy and the results indicated that the dimer of  beta-lactoglobulin (N2)reversibly dissociates into monomeric units (N*) which are structurally distinguishable by changes in their infrared absorbance spectra upon heating. Hence, it is proposed that beta-lactoglobulin follows the conformational path  induced by temperature:N22N*2D. The general   model was validated with these results indicating that it can be employed in the study of the thermodynamics of other homo-oligomeric protein systems.","palabras_clave":"OLIGOMERIC PROTEINS|PROTEIN STABILITY|BETA-LACTOGLOBULIN|DIFFERENTIAL SCANNING CALORIMETRY|FOURIER-TRANSFORMED INFRARED SPECTROSCOPY|THERMODYNAMIC MODEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3020,"idioma_id":4,"titulo":"Glassy  carbon  electrodes  modified  with  a  dispersion  of  multi-wall  carbon nanotubes  in  dopamine-functionalized  polyethylenimine:  Characterization  and analytical  applications  for  nicotinamide  adenine  dinucleotide  quantification.","resumen":"We report the characterization of a dispersion of multiwall carbon nanotubes (CNT) in a solution of polyethylenimine (PEI) functionalized with dopamine (Do), the electrochemical behavior of glassy carbon electrodes (GCE) modified with the resulting dispersion, and its analytical application for the highly sensitive quantification of NADH without fouling of the surface. The dispersion was obtained by sonicating for 60 minutes 1.0 mg CNT in 1.0 mL of 1.0 mg\/mL PEI-Do solution prepared in 50\/50 v\/v ethanol\/water. The presence of Do covalently bonded to PEI promotes hydrophobic &#61552; interactions with the CNT walls and improves significantly the dispersability of CNT in this mixture. The dispersion is highly stable since after 2 months resting at room temperature no phase separation was observed.This dispersion was drop-coated over GCE, and after solvent evaporation, a very reproducible and uniform coverage was obtained. An electrochemical pretreatment (activation) of such a modified GCE electrode allowed the sensitive quantification of NADH at potentials as low as -0.025 V. The response of NADH at the electrochemically activated GCE modified with the dispersion of CNT in PEI-Do solution (GCE\/CNT-PEI-Do), demonstrated to be highly reproducible. The R.S.D. for the NADH sensitivity obtained with 15 electrodes and 3 different dispersions was 8.9 %. Even more important, after 10 calibrations for NADH with the same surface the decrease in the sensitivity was smaller than 10 %. The dispersion was characterized by Field Emission Scanning Electron Microscopy (FE-SEM), Fourier TransformedInfrared Spectroscopy (FT-IR) while the electrodes modified with the dispersion were evaluated using different electrochemical techniques (Cyclic voltammetry (CV), Amperometry and Electrochemical Impedance Spectroscopy (EIS)).","palabras_clave":"Carbon nanotubes functionalization|Electrochemical Sensor|Polyethileneimine|Dopamine|NADH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3022,"idioma_id":4,"titulo":"Development of a larval diet for the South American fruit fly Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae","resumen":"To implement the sterile insect technique (SIT) against Anastrepha fraterculus (Wiedemann), mass-rearing protocols must be developed, in particular a cost-effective larval diet. Key elements of this diet are the optimal nutrients and their concentrations, diet support or a bulking agent and the diet pH. To improve the currently used formulation and develop a more cost-effective diet, we evaluated various supports, sugar contents, nutrient proportions and levels of pH. Egg to pupa recovery increased when a sponge cloth replaced the agar. Although the values obtained were still low, the diet with sugar cane bagasse showed recovery values similar to those of the agar-based diet but the percentage of adult emergence was lower. Larval viability increased when the amount of sugar was doubled. Yet it is still necessary to evaluate this diet on a larger scale and determine the feasibility of reusing the sponge cloth to reduce larval diet costs.","palabras_clave":"MASS-REARING|BULKING AGENT|LIQUID DIET|STERILE INSECT TECHNIQUE|ARTIFICIAL DIET|ANASTREPHA FRATERCULUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3068,"idioma_id":4,"titulo":"Efficient Synthesis of Thiolactoside Glycoclusters by Ruthenium-Catalyzed Cycloaddition Reaction of Disubstituted Alkynes on Carbohydrate Scaffolds","resumen":"Lectin-carbohydrate interactions are responsible for severalcellular processes involved in the immune system and thedevelopment of certain types of cancer. To further understandingof the cellular responses triggered by these interactions,complex carbohydrates are designed and prepared.Here, we describe the synthesis of a family of multivalentglycoclusters based on carbohydrate cores bearing thiolactosidesor thiogalactosides as recognition elements with structuralvalencies ranging from 2 to 8. The synthetic strategyinvolves a key ruthenium-catalyzed cycloaddition reactionbetween symmetric disubstituted alkynes bearing twothiosugar units and azide-containing carbohydrate scaffolds.This methodology afforded high-valency glycoconjugates ingood to excellent yields. Binding affinities of the synthetic &#946;-thiolactosides for peanut lectin were measured by isothermaltitration calorimetry. These titrations revealed micromolar affinitiesas well as a multivalent effect. A tetravalent glycoconjugatebased on a trehalose scaffold displayed the highestbinding affinity.","palabras_clave":"Carbohydrates|Glycoclusters|Click reaction|Ruthenium"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3069,"idioma_id":4,"titulo":"Relative Rate Coefficients of  OH Radical Reactions with CF3CF=CClCF3  and           CF3CH=CHCH2OH. Ozone Depletion Potential Estimate for CF3CF=CClCF3","resumen":"The relative rate method was used to determine the rate coefficients for the reactions of OH radicalswith CF3CF]CClCF3 (k1) and CF3CH]CHCH2OH (k2). Experiments were carried out at (298  2) K andwith CF3CF]CClCF3 (k1) and CF3CH]CHCH2OH (k2). Experiments were carried out at (298  2) K andatmospheric pressure using ultra pure air or ultra pure nitrogen as the gas bath. The k1 value wasmeasured relative to those of chloroethane and ethane, and the k2 value was measured relative tothose of cyclohexene and 1-pentene. The following rate coefficients were derived in units ofcm3 molecule1 s1: k1 ¼ (3.3  0.9)  1013 and k2 ¼ (3.3  0.9)  1011. This is the first experimentaldetermination of k1 and k2. The rate coefficients were used to estimate the atmospheric lifetimes forthe studied haloalkenes considering the OH-initiated oxidation process. The ozone depletion potential(ODP) for CF3CF]CClCF3 was estimated following a recently-developed technique based on Lagrangiantrajectories, which takes into account the time and location of the release of the short-lived halogenatedspecies. 2012 Elsevier Ltd. All rights reserved.","palabras_clave":"OH RADICAL|RATE COEFFICIENT|ATMOSPHERIC CHEMISTRY|HALOGENATED ALKENES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3073,"idioma_id":4,"titulo":"Functional anatomy of male copulatory organs of Pomacea canaliculata (Architaenioglossa, Ampullariidae).","resumen":"This study was aimed to investigate the functional morphology of copulation and sperm transfer in the invasive snail Pomacea canaliculata. Three-dimensional renderings of the male copulatory apparatus were made and showed elaborate systems for innervation and for hemolymph supply and drainage. A key component of the male copulatory apparatus is the penial sheath, which shows three specialized glands; the medial and distal glands may participate in adherence to the mantle cavity wall of the female during copulation. The outer gland has an epithelium composed of columnar cells with branched microvilli, mucous goblet cells and large granular secretory cells containing intragranular crystalloids, which produce an exocrine secretion during copulation. The interaction of male\/female copulatory organs was studied in dissections of snap-frozen pairs. Sperm are left in the sperm pit, at the end of the pallial spermiduct. Afterwards, the muscular action of the penial bulb takes the sperm up to the vermiform penis, which slides from the penial pouch into the central groove of the penial sheath, and it later emerges through a T-shaped sulcus of this structure and enters the female vagina. Then, it climbs through the capsule duct, and its tip reaches the proximity of the seminal receptacle. A model of copulation and sperm transfer is presented on the basis of the new findings and on published literature.","palabras_clave":"GASTROPODS|SNAIL REPRODUCTION|GENITAL SYSTEM|APPLE SNAIL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3078,"idioma_id":4,"titulo":"Probing the combined effect of flunitrazepam and lidocaine on the stability and organization of bilayer lipid membranes. A differential scanning calorimetry and dynamic light scattering study. Trabajo Enviado con primera autoria compartida","resumen":"        Combined effects of flunitrazepam and lidocaine were studied on the  thermotropic equilibrium of dipalmitoyl phosphatidylcholine (dpPC) bilayers.  This adds a thermodynamic dimension to previously reported geometric analysis in  the erythrocyte model. Lidocaine decreased the enthalpy and temperature for dpPC  pre- and main- transitions (DHp,DHm,Tp,Tm) and decreased the  cooperativity of the main transition (DT1\/2,m).  Flunitrazepam decreased DHm  and, at least up to 59 mM, also  decreased DHp. In conjunction with lidocaine,  flunitrazepam induced a recovery of &#8710;T1\/2,m control values and increased  DHm even above the control level. The deconvolution of the  main transition peak at high lidocaine concentrations revealed three components  possibly represented by: a self-segregated fraction of pure dpPC, a dpPC-lidocaine  mixture and a phase with a lipid structure of intermediate stability associated  with lidocaine self-aggregation within the lipid phase. Some lidocaine effects  on thermodynamic parameters were reverted at proper lidocaine\/ flunitrazepam  molar ratios, suggesting that flunitrazepam restricts the maximal availability  of the lidocaine partitioned into the lipid phase. Thus, beyond its complexity,  the lipid-lidocaine mixture can be rationalized as an equilibrium of coexisting  phases which gains homogeneity in the presence of flunitrazepam. This work stresses the relevance of nonspecific  drug-membrane binding on lidocaine-flunitrazepam pharmacological interactions and would have  pharmaceutical applications in liposomal multidrug-delivery.  ","palabras_clave":"Flunitrazepam \u0002 |Lidocaine \u0002|Calorimetry|Liposomes|Thermotropic phase changes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3088,"idioma_id":5,"titulo":"Condiciones Asociadas a la Seropositividad de Enfermedad Celíaca en una Población Adulta","resumen":"RESUMEN  La Enfermedad Celíaca (EC) es un desorden autoinmune que afecta a individuos genéticamente predispuestos en respuesta a la ingesta del gluten presente en el trigo, avena, cebada y centeno. Objetivo: Describir las manifestaciones clínicas, las condiciones asociadas y las características serológicas en la Enfermedad Celíaca del adulto. Métodos: Se estudiaron en forma retrospectiva 1327 adultos entre 14 y 84 años de edad con clínica sugerente de EC, registrándose síntomas de presentación, enfermedades asociadas, serología y  sólo 77 biopsias endoscópicas. Se determinaron Inmunoglobulina A y Anti-transglutaminasa tisular IgA (Anti-TGt-IgA Inova-diagnostic, San Diego, USA). Resultados: De los 1327 pacientes, 162 resultaron seropositivos, con predominio en sexo femenino. La seropositividad estuvo asociada a las siguientes condiciones: anemia 30,25% (49); enfermedades dermatológicas 9,88% (16); enfermedades ginecológicas 11,11% (18); enfermedades óseas 7,41% (12); disfunciones tiroideas 11 (6,79%) y diabetes tipo I 0,62% (1). Catorce pacientes (8,64%) eran familiares de primer grado de Enfermos Celíacos. 8 de cada 10 muestras seropositivas mostraron correlación con biopsias compatible para EC. Conclusión: las condiciones asociadas a la EC del adulto son muy variables. Se recomienda la utilidad de los screening serológicos que incluyan Anti TGt-IgA, para la búsqueda  en población general y de riesgo.      Palabras claves: Enfermedad Celíaca. Anemia. Diabetes. Anti-transglutaminasa tisular.        Abstract  Celiac disease (CD) is an autoimmune disorder that affects genetically predisposed individuals in response to the ingestion of gluten present in wheat, oats, barley and rye. Objective: Describe clinical manifestations, associated conditions and serological characteristics in adult celiac disease. Methods: retrospectively were evaluated 1327 adults between 14 and 84 years with symptoms suggestive of CD and data relating to symptoms, associated diseases, serology and only 77 endoscopic biopsies were collected. Immunoglobulin A and IgA anti-tissue transglutaminase (tTG-IgA Anti-Inova Diagnostics, San Diego, USA) were determined. Results: Of 1327 patients, 162 were seropositive and predominantly female. Seropositivity was associated with the following conditions: anemia 30.25% (49) dermatological diseases 9.88% (16), gynecological diseases 11.11% (18); bone disease 7.41% (12), thyroid dysfunctions 6.79% (11) and type 1 diabetes 0.62% (1). Fourteen patients (8.64%) were first-degree relatives of celiac patients and eight of ten samples correlate with biopsy results compatible with CE. Conclusion: Conditions associated with adult CD vary widely, and serological screenings, including Anti-tTG-IgA, are recommended for adults.","palabras_clave":"ENFERMEDAD CELIACA|ANEMIA|DIABETES|ANTITRANSGLUTAMINASA TISULAR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3092,"idioma_id":4,"titulo":"Assessing the life history of projectile points\/ knives from the Middle Holocene of Argentina?s Southern Puna -DOI 10.1016\/j.quaint.2012.02.048","resumen":"Abstract: Lithic artefacts that belong to hunter-gatherer occupations from the Quebrada Seca 3 site during the Middle Holocene of the southern Puna of Argentina, dating to ca. 4800-5900 cal BP are analyzed. These tools have been defined as stemmed projectile points whose blades were intensively maintained, resulting in asymmetric shapes. However, they have also been defined as knives because of their morphology when discarded. To establish a more complete version of the life history of these artefacts, from projectile points to knives, we developed a research design that includes several analytical microscopic and compositional techniques to identify the uses that were preserved over time. Information obtained through microwear analysis and the study of microscopic residues microfossils and chemical residues- on the blades and stems indicates that these artefacts were used in several functions, with a first use as projectile points and a final use as knives in generalized plant and animal processing. The plant material processed includes roasted or dehydrated tuberous\/roots. The tools were also used to cut animal skin, flesh and\/or bone.Evidence for hafting to foreshafts or handles and for the use of adhesives was also found. The use-traces and life history results were mutually consistent. This contributed to the discussion of artifact life history and resource processing by the Middle Holocene hunter-gatherers of the South Central Andes.","palabras_clave":"projectile point|Southern Argentine Puna| Middle Holocene;| stone tool life history|microfossil| microwear analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3093,"idioma_id":5,"titulo":"Perfil de Mercado de Uva: Vino, Uva de Mesa y Pasas de Uva (Primera Parte)","resumen":"En ésta tercera y última parte del perfil de mercado de uva, nos focalizaremos en la formación delprecio, las barreras comerciales y las conclusiones y recomendaciones. Recordemos que se trata deun trabajo que se fue publicando en los informes de coyuntura Nº89 y Nº90.","palabras_clave":"MERCADO DE UVA|COMERCIO MUNDIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3094,"idioma_id":4,"titulo":"PHYSICAL AND ANTIMICROBIAL PROPERTIES OF TAPIOCA STARCH-HPMC EDIBLE FILMS INCORPORATED WITH NISIN AND\/OR POTASSIUM SORBATE","resumen":"The antimicrobial effectiveness of nisin and potassium sorbate, incorporated individual and combined, in films made with tapioca starch and its mixtures with hydroxypropyl methylcellulose were studied. The combination of antimicrobials was more effective against Listeria innocuaand Zygosaccharomyces bailii than their individual incorporation, with the added advantage of providing greater inhibitory spectrum. The effect of the formulation on some physical properties was also evaluated. The blended biopolymers-based films showed an increase of stress (&#963;r)and elastic modulus (E) but a decrease of the strain at break (&#949;r). In turn, the water vapour permeability and solubility in water were enhanced. In addition, these films were clearer than those made only with starch. It must be remark that, despite the antimicrobial agents modified films physical properties, producing a lower &#963;r and E, a higher &#949;r, solubilityand darker films, they maintained a suitable behaviour as a packaging material.","palabras_clave":"Edible films|Nisin|Potassium sorbate|Antimicrobial activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3096,"idioma_id":5,"titulo":"El estrés en padres de bebés prematuros internados en la unidad de cuidados intensivos neonatales: traducción y adaptación de la escala parental stressor scale: neonatal intensive care unit (pss: nicu ? m.s. miles y d. Holditch davis, 1987; m. S. Miles y","resumen":"El estrés que genera en los padres tener un hijo internadoen la Unidad de Cuidados Intensivos Neonatológicos(UCIN) ha sido investigado en profundidad. Algunos autoreshan encontrado que el nivel de estrés y los síntomasdepresivos, constituyen los factores con mayor poderexplicativo y predictivo respecto de cómo la familia afrontarála internación (Speer, Leef, Epps &amp; Locke, 2002). Esasí, que desde hace varios años ha surgido el interés enevaluar el nivel de estrés percibido por los padres queafrontan un suceso como este, para lo cual se ha utilizado,a nivel mundial, la Escala Parental Stressor Scale: NeonatalIntensive Care Unit (Escala de Estrés Parental:Unidad de Cuidados Intensivos Neonatales (EEP: UCIN)(Miles &amp; Holditch Davis, 1987; Miles &amp; Funk, 1998). Lamisma ha demostrado poseer muy buenas propiedadespsicométricas de validez y confiabilidad en diversos países.Es el objetivo de este trabajo presentar los primerospasos del proceso de adaptación de la prueba Escala deEstrés Parental: Unidad de Cuidados Intensivos Neonatológicos(EEP: UCIN) a nuestro medio. Se analizarán especialmenteel funcionamiento de los reactivos, a partirdel análisis de discriminación de ítems, y de las correlacionesítem-total, y se mostrará la versión final de laprueba obtenida, la cual se validará en futuros estudios","palabras_clave":"ESTRÉS|PADRES|UNIDAD DE CUIDADOS INTENSIVOS NEONATALES|ADAPTACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3097,"idioma_id":5,"titulo":"La conciencia de Huckleberry Finn o la agonía entre la moral y los sentimientos?, (Estudio preliminar)","resumen":"La conciencia de Huckleberry Finn o la agonía entre la moral y los sentimientosGastón BeraldiResumenEste trabajo tiene como objetivo presentar un estudio preliminar y una traducción anotada al artículo que Jonathan Bennett publicara a mediados de los años setenta en la revista Philosophy, y que sirve como disparador para el tratamiento de la motivación moral. La emergencia de la traducción de este artículo surge eminentemente como una necesidad didáctica, ya que las cuestiones relacionadas con la motivación moral han ocupado un lugar central en la historia de la ética, desempeñando un rol protagónico, desde su origen hasta la actualidad.","palabras_clave":"Agonía|Ética|Bennett|Huckleberry Finn"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3098,"idioma_id":5,"titulo":"Evaluación de cultivares de girasol, campaña 2011\/2012","resumen":"En la campaña 2011\/12 se evaluaron 34 híbridos comerciales de maíz y 4 experimentales. Los ensayos se instalaron en un suelo Argiudol típico serie Rafaela de adecuada fertilidad potencial (MO= 2,6%, N total= 0,143%, P= 37,8 ppm y pH= 6,1) y una baja fertilidad actual (N-N03= 1,0 ppm y S-S04= 9 ppm). El contenido hídrico inicial del perfil (134 mm agua útil), medido hasta 1,5 metros de profundidad al momento de la siembra era escaso, representando solo el 41% de la capacidad máxima de retención. La siembra se realizó el 6 de octubre y la emergencia se produjo el 16 del mismo mes. Se utilizó una sembradora de parcelas acondicionada para siembra directa en surcos a 0,70 m entre sí y con una densidad teórica de 7 plantas\/m². La fertilización consistió en la aplicación al voleo de 120 kg\/ha de yeso agrícola previo a la siembra (14\/09\/11) y 70 kg\/ha de N (urea 46%) aplicada al momento de la siembra del cultivo por debajo y al costado de la línea. El 7\/11\/11 se refertilizó con una dosis de N igual a la aplicada durante la siembra. El diseño del ensayo fue de bloques completos al azar con tres repeticiones y las parcelas constaron de cuatro surcos por 6 m de largo (16,8 m2). El ciclo promedio a floración (R1) fue de 68 días, con extremos de 60 y 74 días, considerado normal para la época de siembra. Por su parte, la altura promedio de los materiales al momento de la cosecha fue de 2,06 m (con un rango de 1,75 a 2,33 m). El promedio de rendimiento de grano fue muy bajo (5120 kg\/ha) y sin que el análisis de comparación de medias pudiese agrupar a los materiales por nivel de productividad, como consecuencia de la alta variabilidad. Los bajos rendimientos y alta variabilidad se dieron por las condiciones de sequía en el período de mayor sensibilidad del maíz, que corresponde a la etapa que va de unos 15 días antes de la antesis femenina (R1) hasta 21 días después de la misma. Para la campaña analizada, el rango de fechas de R1 fue del 15 al 29 de diciembre, coincidente con un fuerte déficit hídrico que se prolongó hasta el 10 de enero. El nivel de productividad de la presente campaña estuvo acorde a la respuesta observada cuando se relacionaron los rendimientos promedios de ensayos de maíz de siembras tempranas (septiembre-principios de octubre) con las lluvias de diciembre. Cuando los registros pluviométricos de diciembre son menores a los considerados normales (serie 1930-2010), existe un efecto depresor de los rendimientos, mientras que precipitaciones mayores, sean éstas leves o ampliamente superiores, asegurarán productividades consideradas potenciales para la región. Adicionalmente, se destaca el mayor número de años con lluvias inferiores a las del promedio en el período considerado. ","palabras_clave":"MAIZ|PRODUCTIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3099,"idioma_id":4,"titulo":"Opposite effects of methanandamide on lipopolysaccharide-induced prostaglandin e2 and f2&#945; synthesis in uterine explants from pregnant mice","resumen":"Prostaglandins (PG) are effective abortifacients and are important mediators of lipopolisaccharide (LPS)-induced embryonic resorption (ER). Besides, anandamide (AEA) has been described as one of the major endocannabinoids present in the uterus suggesting that it might play a role in reproduction. It has been reported that high levels of AEA are associated with pregnancy failure and that LPS increases AEA production. Also, it has been observed that AEA modulates PG production in different tissues. In this sense, we studied whether LPS-induced PG production is modulated by AEA and we also assessed the effect of this endocannabinoid on PG metabolism in an in vitro model. Uterine explants from BALB\/c implantation sites were cultured in the presence of LPS plus cannabinoid receptor (CB) specific antagonists and PG production was assessed.Then, we studied the effect of exogenous AEA on different steps of PG metabolic pathway. We showed that AEA is involved in LPS-induced PG biosynthesis. Also, we observed that AEA exerts opposite effects on PGE2 and PGF2alpha biosynthesis, by inhibiting PGE2 production and increasing PGF2alpha levels. We suggest that AEA could be involved in the mechanisms implicated in LPS-induced ER. A better understanding of how AEA could be affecting ER could help developing specific interventions to prevent this pathology.","palabras_clave":"METHANANDAMIDE|LIPOPOLYSACCHARIDE|PROSTAGLANDINS|UTERUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3100,"idioma_id":4,"titulo":"The Chemistry and Structure of Nickel-Tungsten Coatings Obtained by Pulse Galvanostatic Electrodeposition","resumen":"A detailed characterization of electrodeposited NiW coatings prepared by pulse electrodeposition on steel and copper substrates is presented. The coatings were obtained at high current pulse frequency and show high microhardness and absence of brittleness. The surface of the coating consists of nanometer sized crystals forming a cauliflower-like structure protected by a mixture of nickel and tungsten oxides. The cauliflower structure is preserved into the bulk coating that exhibits an average composition &#8776;70 at% Ni30 at% W. Different phases are observed in the bulk structure: a W-rich amorphous phase (&#8776;40%) and Ni-rich crystalline phases (&#8776;60%). The crystalline phases consist of crystalline domains &#8776;7 nm in size of Ni(W) (fcc) solid solution (12 at% W content) and a minor Ni4W component (less than 10%). The amorphous phase exhibits a less compact NiW structure where some amount of C could also be present. Oxidized W species cannot be detected in the bulk coating, thus discarding the presence of significant amounts of tungsten carbide, tungstates or citrate\u2013tungsten complexes. Our results shed light on controversial points related to the chemical composition and demonstrate the complex structure of this system.","palabras_clave":"Pulse electrodeposition|NiW alloys|Nanostructured materials|X-ray synchrotron radiation|HRTEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3101,"idioma_id":4,"titulo":"Pathogen translocation and histopathological lesions in an experimental model of Salmonella Dublin infection in calves receiving lactic acid bacteria and lactose supplements","resumen":"The purpose of this study was to evaluate the capacity of a  lactic acid bacteria (LAB) inoculum to protect calves with or  without lactose supplements against Salmonella Dublin  infection by evaluating histopathological lesions and pathogen  translocation. Fifteen calves were divided into three groups  [control group (C-G), a group inoculated with LAB (LAB-G),  and a group inoculated with LAB and given lactose  supplements (L-LAB-G)] with five, six, and four animals,  respectively. The inoculum, composed of Lactobacillus (L.)  casei DSPV 318T, L. salivarius DSPV 315T, and Pediococcus  acidilactici DSPV 006T, was administered with milk replacer.  The LAB-G and L-LAB-G received a daily dose of 109 CFU\/kg  body weight of each strain throughout the experiment.  Lactose was provided to the L-LAB-G in doses of 100 g\/day.  Salmonella Dublin (2 × 1010 CFU) was orally administered to  all animals on day 11 of the experiment. The microscopic  lesion index values in target organs were 83%, 70%, and  64.3% (p &#65308; 0.05) for the C-G, LAB-G, and L-LAB-G,  respectively. Administration of the probiotic inoculum was  not fully effective against infection caused by Salmonella.  Although probiotic treatment was unable to delay the arrival  of pathogen to target organs, it was evident that the inoculum  altered the response of animals against pathogen infection.","palabras_clave":"calves,|Lactobacillus,|lactose,|probiotic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3102,"idioma_id":4,"titulo":"Exposure to selected pathogens in Geoffroys cats and domestic carnivores from central Argentina","resumen":"Wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. Because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens in 40 Geoffroy\u2019s cats (Leopardus geoffroyi) sampled between 2000 and 2008 within or near two protected areas in central Argentina (Lihue Calel National Park, La Pampa, and Campos del Tuyu National Park, BuenosAires), as well as five domestic cats and 11 domestic dogs from cattle ranches adjacent to Lihue Calel Park. Geoffroy\u2019s cats had detectable antibody to canine distemper virus (CDV), feline calicivirus (FCV), feline coronavirus, feline panleukopenia virus (FPV), Toxoplasma gondii, Leptospira interrogans (serovars Ictero\/Icter and Ballum), and Dirofilaria immitis. None of the wild cats had antibodies to feline herpesvirus, feline immunodeficiency virus (FIV), feline leukemia virus, or rabies virus. Domestic dogs had antibodies to CDV, canine adenovirus, canine herpesvirus, and canine parvovirus. Antibodies to FPV, FCV, FIV, and T. gondii were found in domestic cats. We provide the first data on exposure of free-ranging Geoffroy\u2019s cats to pathogens at two sites within the core area of the species distribution range, including the first report of antibodies to CDV in this species. We encourage continued monitoring for diseases in wild and domestic carnivores as well as preventive health care for domestic animals, particularly in park buffer zones where overlap is greatest.","palabras_clave":"Argentina|Domestic carnivores|domestic-wild interface|Leopardus geoffroyi|pathogens|serosurvey"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3103,"idioma_id":4,"titulo":"Novel biopolymer matrices for microencapsulation of phages: enhanced protection against acidity and protease activity","resumen":"Phage therapy by oral administration as a strategy to reduce enterohemorrhagic E. coli from cattle requires enhanced resistance of phage to the harsh gastric conditions (extreme acidity and protease activities). The purpose of this work is the microencapsulation of phage in non-toxic and natural biopolymeric matrices as a protective barrier against gastric environment. Alginate and pectin are used as base polymers. Further emulsification with oleic acid or coating with a different biopolymer is also under study. Emulsified pectin gel micropsheres showed the maximum encapsulation efficiency and the highest protection against acidity, leaving more than 103 active phages after 30 min. exposure at pH 1.6, and allowing a full retention of phage titre after 3h incubation with pepsin (4.2 mg ml-1). Full inactivation of non-encapsulated phage at pH 1.6 or with 0.5 mg ml-1 pepsin after 10 min. incubation was found. The results obtained in vitro strongly suggest that emulsified gel pectin matrix may significantly increase phage resistance to the gastric system for oral delivery.","palabras_clave":"BIOCONTROL |BIOLOGICAL APPLICATION OF POLYMERS|BIOPOLYMERS|MICROENCAPSULATION|PHAGE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3104,"idioma_id":4,"titulo":"INFLAMMATION-HEMOSTASIS RELATIONSHIP IN INFECTED MALNOURISHED MICE. MODULATORY EFFECT OF Lactobacillus casei CRL 431","resumen":"Abstract  Objective and design The coagulation system is considered part of the defense machinery, but its excessive activation can lead to additional damage. We studied the effects of oral administration of Lactobacillus casei CRL 431-a probiotic bacterium-on the activation of coagulation and the relationship with inflammatory parameters during a respiratory infection in malnourished mice. Materials and methods Malnourished Swiss albino mice were nourished with a balanced commercial diet (BCD) for 7 days or BCD with L. casei for the last 2 days (BCD+Lc). BCD, BCD+Lc, malnourished (MNC) and well-nourished controls (WNC) were infected with Streptococcus pneumoniae. Blood and bronchoalveolar lavage  samples were obtained at different times post-infection. Results and conclusions Malnutrition altered most of the evaluated parameters before and after infection. The repletion diet with supplemental L. casei was the most effective in limiting coagulation activation and normalizing  coagulation inhibition mechanisms. These findings will help develop further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.","palabras_clave":"HEMOSTASIS|INFLAMATION|LACTOBACILLUS CASEI|MALNUTRITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3105,"idioma_id":4,"titulo":"Distribution and characterization of Shiga toxin-producing E. coli in        environmental samples from a dairy farm","resumen":"Environmental samples were taken from ground, cattle water troughs, and feeders from a dairy farm with different STEC prevalence between animal categories (weaning calves, rearing calves, and dairy cows). Overall, 23 % of samples were positive for stx genes, stx(2) being the most prevalent type. Isolates were analyzed by PCR monoplex to confirm generic E. coli and by two multiplex PCR to investigate the presence of stx(1), stx(2), eae, saa, ehxA, and other putative virulence genes encoded in STEC plasmids: katP, espP, subA, and stcE. The toxin genes were subtyped and the strains were serotyped. The ground and the environment of the rearing calves were the sites with the highest number of STEC-positive samples; however, cattle water troughs and the environment of cows were the places with the greater chance of finding stx(2EDL933) which is a subtype associated with serious disease in humans. Several non-O157 STEC serotypes were detected. The serotypes O8:H19; O26:H11; O26:H-; O118:H2; O141:H-; and O145:H- have been asociated with human illness. Furthermore, the emergent pathogen STEC O157:H- (stx(1)-ehxA-eae) was detected in the environment of the weaning calves. These results emphasize the risk that represents the environment as source of STEC, a potential pathogen for human and suggest the importance of developing control methods designed to prevent contaminations of food products and transmission from animal to person.","palabras_clave":"cattle water| environmental samples| shiga toxin-"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3106,"idioma_id":5,"titulo":"Una herramienta para monitorear sequias en regiones áridas y semiáridas de Patagonia Norte","resumen":"La variabilidad ambiental es una característica de regiones pastoriles áridas y semiáridas, siendo la sequía uno de los principales problemas en sistemas ganaderos extensivos, con implicancias productivas y económicas tanto a escala predial como regional. El monitoreo regional de los procesos de sequía es una herramienta fundamental y necesaria, como complemento de propuestas y manejos adaptativos activos que busquen mitigar los impactos sobre la producción. En el presente artículo proponemos una herramienta para el monitoreo de sequías en zonas áridas y semiáridas, basada en datos provistos por sensores remotos. El objetivo fue desarrollar un sistema de monitoreo basado en un índice espectral, desagregando la heterogeneidad biofísica regional en unidades homogéneas, y relacionándola con los momentos clave de decisiones asociadas al manejo ganadero tradicional, en sistemas de producción ovina de Patagonia Norte. Esta integración permite acercar esta herramienta a la toma de decisiones a escala regional, fundamentalmente para instituciones y organizaciones locales, y colaborar con información en el diseño y desarrollo de políticas vinculadas al manejo ganadero adaptativo. Finalmente, discutimos los alcances de la herramienta y los desafíos futuros, asociados al desarrollo de sistemas de alerta temprana y mitigación de sequías en regiones áridas y semiáridas.","palabras_clave":"alerta temprana|sensores remotos|vulnerabilidad|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3107,"idioma_id":5,"titulo":"¿La práctica de la siembra directa en cultivos de soja favorece a las poblaciones de acridios (Orthoptera: Acrididae), en el partido de Benito Juárez?","resumen":"Considerando el desarrollo del cultivo de soja en siembra directa en el partido de Benito Juárez y que algunos autores sostienen que esta práctica favorece a los acridios, se evaluó la riqueza de especies y la abundancia en sojas con siembra directa y convencional. Se registraron siete especies (Aleuas lineatus Stål, Covasacris pallidinota (Bruner), Baeacris pseudopunctulatus (Ronderos), Dichroplus elongatus Giglio-Tos, Dichroplus maculipennis (Blanchard), Dichroplus pratensis Bruner y Scotussa lemniscata (Stål). La riqueza de especies acumulada en los diferentes cultivos fue similar (p&gt; 0,05). En soja de primera con siembra directa se registraron 2,3 ± 0,19 especies, en soja de primera con siembra convencional 1,45 ± 0,15 especies, y en soja de segunda con siembra directa 2,25 ± 0,28 especies. Dichroplus elongatus fue la especie más abundante en todos los cultivos y en todos los momentos. Las restantes especies presentaron baja abundancia y se registraron en algunos momentos. No existió diferencia (p&gt; 0,05) en la abundancia de tucuras entre los cultivos y en las diferentes fechas de muestreo. La baja riqueza de especies registrada estaría relacionada con la baja diversidad vegetal de los cultivos. Este estudio no mostró diferencias en la abundancia y riqueza de especies de acuerdo a la labranza utilizada. ","palabras_clave":"Tucuras|Riqueza|Sistemas de Labranza|Glycine max"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3108,"idioma_id":4,"titulo":"Numerical simulation of wind waves at the Río de la Plata:  evaluation of four global atmospheric databases","resumen":"The performance of NCEP\/NCAR I, NCEP\/DOE II, JRA-25 and ERA-Interim global databases, implemented as atmospheric forcings of the SWAN model in the Río de la Plata region, was quantitatively tested by calculating the bias, the mean square root error, the determination coefficient and the slope of the line fitted between observed and simulated wave parameters (significant wave height, mean period and direction). Even though statistical estimators showed no evident differences for wave periods and directions some noticeable differences were observed for simulated significant wave heights depending on the forcing used. The lowest bias (0.22 m) was obtained when the SWAN model was forced by ERA-Interim. With regard to the mean square root errors, the lowest values were obtained when NCEP\/NCAR I (0.16 m) and NCEP\/DOE II (0.19 m) were used as forcing. In addition, the best slope for simulated heights (0.79) was obtained using NCEP\/DOE II.Computed determination coefficients for heights, periods and directions were very similar (0.89-0.93) for all the simulations carried out in this study. Energetic and severe wave events were given special consideration. The most energetic wave episode recorded in the Río de la Plata mouth (24 August, 2005) was analyzed and discussed in particular. It was concluded that during energetic atmospheric conditions the best agreement is achieved by implementing NCEP\/DOE II as forcing. In the light of these results it is concluded that NCEP\/DOE II is the most suitable atmospheric forcing to simulate wave heights with the SWAN model in the Río de la Plata region.","palabras_clave":"NCEP\/NCAR REANALYSIS I|NCEP\/DOE REANALYSIS II,|JRA-25 REANALYSIS|ERA-INTERIM|SWAN MODEL|RÍO DE LA PLATA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3109,"idioma_id":5,"titulo":"ARQUITECTURA BIOCLIMÁTICA EN ZONAS ÁRIDAS  DEL CORREDOR BIOCEÁNICO CENTRAL - Dpto. Iglesia, San Juan","resumen":"Se presentan resultados de estudios realizados en el Departamento de Iglesia, provincia de San Juan, donde próximamente se concluirá el tramo fronterizo del Corredor Bioceánico Central, que une Porte Alegre con Coquimbo. Caracterizados ambientalmente 10 asentamientos en el área de influencia de dicho Corredor, se calcularon Estrategias de Diseño Bioclimático, individualizándose Pautas de diseño Urbano-Arquitectónico Ambiental; de Diseño Arquitectónico Bioclimático y de Diseño Tecnológico Bioclimático; además de Prácticas Constructivas Bioclimáticas. Los resultados reúnen información ambiental y climática necesaria para aplicar al diseño urbano y arquitectónico en estas zonas rurales de ecosistemas áridos.","palabras_clave":"ZONAS ÁRIDAS|ARQUITECTURA BIOCLIMÁTICA|CARACTERIZACIÓN AMBIENTAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3110,"idioma_id":5,"titulo":"EFECTO DEL TRATAMIENTO DE PROANTOCIANIDINAS EXTRAÍDAS DE LIGARIA CUNEIFOLIA (LC) A DISTINTOS TIEMPOS DE ADMINISTRACIÓN EN RATAS WISTAR  CON DIETA HIPERCOLESTEROLÉMICA SOBRE LA CONCENTRACIÓN DE COLESTEROL PLASMÁTICO Y LA DEFORMABILIDAD ERITROCITARIA.","resumen":"Lc o 'muérdago criollo', su infusión es utilizada en medicina popular para  dar mayor fluidez a la sangre disminuyendo el exceso de colesterol(Co)  plasmático. Anteriormente demostramos que ratas tratadas con extracto crudo de  Lc por vía intraperitoneal (i.p.), disminuye el Co plasmático y aumenta la  viscosidad sanguínea(VS). Del extracto crudo se purificó Proantocianidina  (PLc).Objetivo: analizar el efecto del tratamiento de distintas dosis de PLc  sobre la concentración de Co plasmático y la viscosidad sanguínea (VS). ","palabras_clave":"PROANTOCIANIDINA|LIGARIA|COLESTEROL|VISCOSIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3111,"idioma_id":4,"titulo":"pH Variation in Sorghum micro silage (Abstract)","resumen":"The variation of pH of Sorghum (Silage King Pannar®) microsilage (whole plant shortly chipped, in 1010 cm3 plastic jar with screw cap) was evaluated by 18 treatments: cutting moments (CM): M1 early (22.5% DM, milk stage), M2 recommended (35% DM, soft dough) and M3 late (> 40% DM, hard dough); addition of lactosilo® (AD): with (L) and without lactosilo® (WL) and different opening moments since ensilaged (OM): 2, 12 and 40 days. Factorial ANOVA and average contrast (Bonferroni, p<0.05) were done. The main factors (CM, AD and OM) and double and triple interactions, explained variations in pH (p<0.05). Four groups were identified by contrast pH averages analysis. Two extremes: M1 (L and WL) at 40 days and M3 (L and WL) at 2 days of opening (3.0 vs. 5.5). Another group with intermediate values within the optimum range (3.8 to 4.2), composed of: M2 (L and WL) at 10 and 40 days of opening, M1 (L and WL) at 10 and M1 L at 2 days opening. The rest of the treatments formed a fourth group, exceeding the higher limit of the optimal range (4.4 to 4.9). With this technique, cut in paste grain helps stabilization of the pH at 10 days of ensilaged (with or without lactosilo®). In early cuts, lactosilo® can reach the desired pH at 2 days of ensilaged. Belated cuts do not guarantee properly pH stabilization, even with the application of additives.","palabras_clave":"Sorghum micro silage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3114,"idioma_id":4,"titulo":"Search for squarks and gluinos using final states with jets and missing transverse momentum with the ATLAS detector in &#8730;s = 7 TeV proton-proton collisions","resumen":"A search for squarks and gluinos in events containing jets, missingtransverse momentum and no electrons or muons is presented. The datawere recorded in 2011 by the ATLAS experiment in &lt;imgheight='16' border='0' style='vertical-align:bottom' width='74'alt='View the MathML source' title='View the MathML source'src='http:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S037026931200192X-si2.gif'&gt;proton?proton collisions at the Large Hadron Collider. No excess abovethe Standard Model background expectation is observed in 1.04&nbsp; fb&#8722;1of data. Gluino and squark masses below 700 GeV and 875 GeVrespectively are excluded at the 95% confidence level in simplifiedmodels containing only squarks of the first two generations, a gluinooctet and a massless neutralino. The exclusion limit increases to 1075GeV for squarks and gluinos of equal mass. In MSUGRA\/CMSSM models with &lt;imgheight='13' border='0' style='vertical-align:bottom' width='67'alt='View the MathML source' title='View the MathML source'src='http:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S037026931200192X-si4.gif'&gt;, A0=0 and &#956;&gt;0,squarks and gluinos of equal mass are excluded for masses below 950GeV. These limits extend the region of supersymmetric parameter spaceexcluded by previous measurements.","palabras_clave":"SUPERSYMMETRY|SQUARKS|GLUINOS|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3132,"idioma_id":4,"titulo":"Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics","resumen":"The frustratometer is an energy landscape theory-inspired algorithm that aims at quantifying the location of frustration manifested in protein molecules. Frustration is a useful concept for gaining insight to the proteins biological behavior by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift the energetics. Sites of high local frustration often indicate biologically important regions involved in binding or allostery. In contrast, minimally frustrated linkages comprise a stable folding core of the molecule that is conserved in conformational changes. Here, we describe the implementation of these ideas in a webserver freely available at the National EMBNet node?Argentina, at URL: http:\/\/lfp.qb.fcen.uba.ar\/embnet\/.","palabras_clave":"FRUSTRACION|PROTEINAS|PAISAJES ENERGETICOS|BIOINFORMATICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3184,"idioma_id":4,"titulo":"Identification of a unique 'galectin signature' during progression of human prostate cancer places galectin-1 as a major target of anti-angiogenic therapy in advanced stages of the disease.","resumen":"Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells. Despite considerable progress in identifying the roles of individual galectins in tumor biology, an integrated portrait of the galectin network in different tumor microenvironments is still missing. We undertook this study to analyze the 'galectin signature' of the human prostate cancer microenvironment with the overarching goal of selecting novel-molecular targets for prognostic  and therapeutic purposes. In examining androgen-responsive and castration-resistant prostate cancer cells and primary tumors representing different stages of the disease, we found that galectin-1 (Gal-1) was the most abundantly expressed galectin in prostate cancer tissue and was markedly upregulated during disease progression.  In contrast, all other galectins were expressed at lower levels: Gal-3, -4, -9, and -12 were downregulated during disease evolution, whereas expression of Gal-8 was unchanged. Given the prominent regulation of Gal-1 during prostate cancer progression and its predominant localization at the tumor-vascular interface, we analyzed the potential role of this endogenous lectin in prostate cancer angiogenesis. In human prostate cancer tissue arrays, Gal-1 expression correlated with the presence of blood vessels, particularly in advanced stages of the disease.  Silencing Gal-1 in prostate cancer cells reduced tumor vascularization without altering expression of other angiogenesis-related genes. Collectively, our findings identify a dynamically regulated 'galectin-specific signature' that accompanies disease evolution in prostate cancer, and they highlight a major role for Gal-1 as a tractable  target for antiangiogenic therapy in advanced stages of the disease. Cancer Res; 73(1); 86?96. 2012 AACR.","palabras_clave":"Prostate Cancer|Protein\/glycan interactions|galectins|angiogenesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3188,"idioma_id":4,"titulo":"TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis","resumen":"In addition to its well-known pro-inflammatory effects, tumor necrosis factor (TNF)displays anti-inflammatory activities through mechanisms poorly understood.Previously, we reported the development of severe chronic Yersinia enterocoliticainducedreactive arthritis (ReA) in mice lacking the TNF receptor (TNFR)p55. Asregulatory T (Treg) cells limit chronic inflammation, here we aim to investigate theexpansion and function of CD4+CD25+FoxP3+ Treg cells in the ReA animal model. Thenumber of Treg cells as well as the FoxP3 mRNA expression and IL-10 levels weresignificantly decreased in joint regional lymph nodes (RLN) of TNFRp55-\/- mice versuswild-type (WT) mice at the arthritis onset. However, at chronic phase of arthritis, thenumber of Treg cell in TNFRp55-\/- was similar to WT mice. To explore the in vivofunction of Treg cells at this chronic phase in WT and TNFRp55-deficient mice, weadoptively transferred CD4+ T cells from TNFRp55-deficient mice of day 21, into naïveWT or TNFRp55-\/- mice. When knockout mice were used as recipients we observedhigher delayed-type hypersensitivity (DTH) responses and joint inflammation afterheat-killed Yersinia (HKY) stimulation. Accordingly, we found higher levels of IL-17,IFN-&#947;, IL-6, TGF-&#946;1 and IL-12\/23p40 and lower IL-10 levels in RLN of pawschallenged with HKY in TNFRp55-\/- recipient mice. In addition, we found that CD4+ Tcells from TNFRp55-\/- mice controlled antigen-specific IL-12\/23(p40) production inrecipient WT mice. Our results show that TNFRp55 controls the induction and functionof Treg cells through differential regulation of cytokine production, suggesting a novelmolecular target for immune intervention in ReA.","palabras_clave":"REACTIVE-ARTHRITIS |REGULATORY-T-CELLS|TNF|TNRFP55|YERSINIA ENTEROCOLITICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3200,"idioma_id":4,"titulo":"Retinoic acid receptors move in time with the clock in the hippocampus. Effect of a vitamin-A-deficient diet.","resumen":"  An endogenous time-keeping mechanism controls circadian biological rhythms in mammals.  Previously, we showed that the vitamin A deficiency modifies clock BMAL1 and PER1 as well as  BDNF and Neurogranin daily rhythmicity in the rat hippocampus, when animals are maintained  under 12h-light:12h-dark conditions. Retinoic acid nuclear receptors, RARs and RXRs, have been  detected in the same brain area. Our objectives were 1) to analyze whether RARá, RARâ and   RXRâ exhibit a circadian variation in the rat hippocampus, 2) to investigate the effect of a vitamin   A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ      A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ        RXRâ exhibit a circadian variation in the rat hippocampus, 2) to investigate the effect of a vitamin   A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ      A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ        á, RARâ and   RXRâ exhibit a circadian variation in the rat hippocampus, 2) to investigate the effect of a vitamin   A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ      A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ      â exhibit a circadian variation in the rat hippocampus, 2) to investigate the effect of a vitamin   A-deficient diet on the circadian expression of BMAL1, PER1 and retinoic acid receptors (RARs  and RXRâ) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ    â) genes. Holtzman male rats from control and vitamin A-deficient groups were   maintained under 12h-light:12h-dark or 12h-dark:12h-dark during the last week of treatment.  RARá, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRâ  á, RARâ, RXRâ, BMAL1 and PER1 transcript and protein levels were determined in   hippocampus samples isolated every 4h in a 24h period. Regulatory regions of RARs and RXRââ   genes were scanned for clock-responsive sites while BMAL1 and PER1 promoters were analyzed  for RAREs and RXREs. E-box and RORE sites were found on regulatory regions of retinoid  receptors genes, which display an endogenously-controlled circadian expression in the rat  hippocampus. Those temporal profiles were modified when animals were fed with a vitamin Adeficient  diet. Similarly, the nutritional vitamin A deficiency phase shifted BMAL1 and abolished  PER1 circadian expression at both, mRNA and protein levels. Our data suggests that the vitamin  A deficiency may affect the circadian expression in the hippocampus by modifying the rhythmic  profiles of retinoic acid receptors.","palabras_clave":"RAR-RXR|VITAMIN A|CIRCADIAN RHYTHM|HIPPOCAMPUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3203,"idioma_id":4,"titulo":"Immune -related gene expression in nurse honey bee (Apis mellifera) exposed to synthetic acaricides","resumen":"The mite Varroa destructor is an ectoparasite affecting honey bees worldwide. Synthetic acaricides have been among the principal tools available to beekeepers for its control, although several studies have shown its negative effects on honey bee physiology. Recent research suggests that those molecules strongly impact on immune signaling cascades and cellular immunity. In the present work, LC50 in six-day-old bees were determined for the following acaricides: tau-fluvalinate, flumethrin, amitraz and coumaphos. According to this obtained value, a group of individuals was treated with each acaricide and then processed for qPCR analysis. Transcript levels for genes encoding antimicrobial peptides and immune-related proteins were assessed. Flumethrin increased the expression of hymenoptaecin when comparing treated and control bees. Significant differences were recorded between coumaphos and flumethrin treatments, while the first one reduced the expression of hymenoptaecin and abaecin, the last one up-regulated their expressions. No significant statistically changes were recorded in the expression levels of vitellogenin, lysozyme or glucose dehydrogenase among bees treated with acaricides and control bees. This work constitutes the first report, under laboratory conditions, about induction of immune related genes in response to synthetic miticides.","palabras_clave":"Inmunidad|Apis Mellifera|Acaricidas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3204,"idioma_id":4,"titulo":"Ribbed GFRP (glass fiber reinforced plastic) rebar embedded in concrete - an experimental study","resumen":"Different types of surface treatment were applied to the smooth rods in order to enhance the bond with concrete. Firstly, the rods were machined using a lathe and a grinding stone to create lugs with different configurations. Secondly, the rods were coated with sand fixed with a thin layer of epoxy resin.   The experimental results indicate that the bond strength is highest when the failure mode is a combination of two mechanisms: shearing off of the concrete lugs and that of the FRP lugs. With regard to the variation of lug width, the friction and interlock forces have a greater influence on bond strength. With respect to the height of the lug, the strength increases compared with the results obtained without sand. However the internal diameter doesn´t affect bond strength.","palabras_clave":"Composites|Pultrused bars|mortar|interface"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3205,"idioma_id":4,"titulo":"Effect of entomopathogenic nematodes on the plant-parasitic nematode Nacobbus aberrans (Thorne, 1935) Thorne & Allen, 1944.","resumen":"Nacobbus aberrans is a sedentary endoparasite  nematode that forms galls in the roots of infected plants and  produces important economic losses in some countries of the  American continent. It has a wide host range, attacking mainly  potato, tomato, sugar beet, and pepper crops. A reduction in  the plant-parasitic nematode populations in the presence of  entomopathogenic nematodes (EPNs) has been frequently  reported. In the present work, the effect of the application of  two native EPN isolates (Steinernema rarum and Heterorhabditis  bacteriophora) on a N. aberrans population was evaluated  in tomato plants under greenhouse conditions. Sixty days  after inoculation, the number of galls and egg masses and the  reproduction factor (RF) of N. aberrans were calculated. Of  the variables analyzed, only the RF was significantly lower in  both EPN treatments than in control. N. aberrans reproduction  decreased by 57 and 53 % in plants inoculated with S. rarum  and H. bacteriophora, respectively. These results showed that  EPNs and their bacterial symbionts affected the reproductive  potential of the N. aberrans population. This is the first study  addressing the use of EPNs in the control of this important  plant-parasitic nematode.","palabras_clave":"Biological control|Heterorhabditis bacteriophora|Steinernema rarum|Nacobbus aberrans"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3208,"idioma_id":4,"titulo":"Recognition-driven layer-by-layer construction of multiprotein assemblies on surfaces: a biomolecular toolkit for building up chemoresponsive bioelectrochemical interfaces","resumen":"ABSTRACT      The development of soft bioelectronic interfaces with accurate compositional and topological control of the supramolecular architecture attracts intense interest in the fast-growing field of bioelectronics and biosensing. The present study explores the recognition-driven layer-by-layer assembly of glycoenzymes onto electrode surfaces. The design of the multi-protein interfacial architecture is based on the multivalent supramolecular carbohydrate?lectin interactions between redox glycoproteins and concanavalin A (Con A) derivatives. Specifically, [Os(bpy)2Clpy]2+-tagged Con A (Os-Con A) and native Con A were used to direct the assembly of horseradish peroxidase (HRP) and glucose oxidase (GOx) in a stepwise topologically controlled procedure. In our designed configuration, GOx acts as the biorecognition element to glucose stimulus, while HRP acts as the transducing element. Surface plasmon resonance (SPR) spectroscopy and quartz crystal microbalance with dissipation (QCM-D) results are combined to give a close representation of the protein surface coverage and the content of water in the protein assembly. The characterization is complemented with in situ atomic force microscopy (AFM) to give a topographical description of the layers assemblage. Electrochemical (EC) techniques were used to characterize the functional features of the spontaneously self-assembled biohybrid architecture, showing that the whole system presents efficient electron transfer and mass transport processes being able to transform micromolar glucose concentration into electrical information. In this way the combination of the electroactive and nonelectroactive Con A provides an efficient strategy to control the position and composition of the protein layers via recognition-driven processes, which defines its sensitivity toward glucose. Furthermore, the incorporation of dextran as a permeable interlayer able to bind Con A promotes the physical separation of the biochemical and transducing processes, thus enhancing the magnitude of the bioelectrochemical signal. We consider that these results are relevant for the nanoconstruction of functional biointerfaces provided that our experimental evidence reveals the possibility of locally addressing recognition, transduction and amplification elements in interfacial ensembles via LbL recognition-driven processes.","palabras_clave":"IBIOELECTRONIC NTERFACES|SOFT MATTER|GOx|RECOGNITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3209,"idioma_id":5,"titulo":". Categorización del estado de conservación de los Anfibios de la República Argentina.","resumen":"A más de una década de la primera Lista Roja de herpetofauna propuesta por la Asociación Herpetológica Argentina (Lavilla et al., 2000), se recategorizaron los anfibios a partir de nueva información taxonómica, biogeográfica, bio-ecológica y de modificaciones metodológicas respecto a la evaluación anterior. Mediante la participación de 35 especialistas de toda la Argentina se reevaluaron 175 taxones de anfibios (171 en la anterior) incluyendo 23 taxones nuevos para Argentina y obteniéndose como resultado la inclusión de 51 especies en la Lista Roja (8 En Peligro, 11 Amenazadas, 32 Vulnerables), 21 Insuficientemente Conocidas y 103 No Amenazadas. En relación con la categorización anterior de la AHA, los cambios de categorías han sido: un taxón descendió de las categorías En Peligro a Amenazado, siete taxones descendieron de Amenazados o Vulnerables a Insuficientemente Conocidos y nueve de Insuficientemente Conocidos a No Amenazados. Tres No Amenazados y 10 Insuficientemente Conocidos fueron elevados a distintas categorías de amenaza, nueve taxones Vulnerables fueron elevados a Amenazados, cinco de Vulnerables a En Peligro, y un taxón fue elevado de Amenazado a En Peligro. De 23 taxones no evaluados en el 2000, 16 se ubican en la categoría No amenazados, tres en Insuficientemente Conocidos y cuatro en Vulnerables. Estas modificaciones son el resultado de:(1) mayor información sistemática, biogeográfica y bio-ecológica disponible para la evaluación (2) cambios en cuanto a las presiones antrópicas sobre las especies o sus hábitats, (3) modificaciones metodológicas que incluyeron instructivos para aplicar los conceptos, la discusión y consenso entre especialistas y el análisis de las incertidumbres.","palabras_clave":"ANFIBIOS|CONSERVACION|LISTAS ROJAS|EVALUACIÓN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3210,"idioma_id":4,"titulo":"Dexamethasone counteracts the immunostimulatory effects of triiodothyronine (T3) on dendritic cells","resumen":"Glucocorticoids (GCs) are widely used as anti-inflammatory and immunosuppressive agents. Several studies have indicated the important role of dendritic cells (DCs), highly specialized antigen-presenting and immunomodulatory cells, in GC-mediated suppression of adaptive immune responses. Recently, we demonstrated that triiodothyronine (T3) has potent immunostimulatory effects on bone marrow-derived mouse DCs through a mechanism involving T3 binding to cytosolic thyroid hormone receptor (TR) â1, rapid and sustained Akt activation and IL-12 production. Here we explored the impact of GCs on T3-mediated DC maturation and function and the intracellular events underlying these effects. Dexamethasone (Dex), a synthetic GC, potently inhibited T3-induced stimulation of DCs by preventing the augmented expression of maturation markers and the enhanced IL-12 secretion through mechanisms involving the GC receptor. These effects were accompanied by increased IL-10 levels following exposure of T3-conditioned DCs to Dex. Accordingly, Dex inhibited the immunostimulatory capacity of T3-matured DCs on naive T-cell proliferation and IFN-ã production while increased IL-10 synthesis by allogeneic T cell cultures. A mechanistic analysis revealed the ability of Dex to dampen T3 responses through modulation of Akt phosphorylation and cytoplasmic-nuclear shuttling of nuclear factor-êB (NF-êB). In addition, Dex decreased TRâ1 expression in both immature and T3-maturated DCs through mechanisms involving the GC receptor. Thus GCs, which are increased during the resolution of inflammatory responses, counteract the immunostimulatory effects of T3 on DCs and their ability to polarize adaptive immune responses toward a T helper (Th)-1-type through mechanisms involving, at least in part, NF-êB- and TRâ1-dependent pathways. Our data provide an alternative mechanism for the anti-inflammatory effects of GCs with critical implications in immunopathology at the cross-roads of the immune-endocrine circuits.","palabras_clave":"GLUCOCORTICOIDS|DENDRITIC CELLS |THYROID HORMONE RECEPTOR Beta 1|NUCLEAR FACTOR-êB (NF-êB)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3211,"idioma_id":4,"titulo":"Cyclin D1 is a NF-B corepressor","resumen":"NF-êB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-êB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-êB activity. We found that CD1 inhibits NF-êB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3. In both, tumoral and non-tumoral cells, the expression pattern of RAC3 and CD1 is regulated by the cell cycle, showing a gap between the maximal expression levels of each protein. The individual increase, by transfection, of either CD1 or RAC3 enhances cell proliferation. However the simultaneous and constitutive over-expression of both proteins has an inhibitory effect. Our results suggest that the relative amounts of CD1 and RAC3, and the timing of expression of these oncogenes could tilt the balance of tumor cell proliferation in response to external signals.","palabras_clave":"NF-kB|tumor|corepressor|Cyclin D1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3212,"idioma_id":4,"titulo":"Binding and Encapsulation of Doxorubicin on Smart Pectin Hydrogels for Oral Delivery","resumen":"Pectins (Pec) of 33 to 74 % esterification degree were tested with doxorubicin (Dox), a very high toxic drug widely used in cancer therapies. Pec with 35 and 55 % DE were selected because of the Dox binding higher than Pec microspheres of 35 and 55 % obtained by ionotropic gelation with Ca+2 have 88 and 66 % Dox loading capacity. Kinetic Dox release showed more than 80.0 and about 30.0 % free drug from 35 % and 55 % Pec formulations at pH 7.4, and 37 °C after 1-h incubation, respectively. Besides, Dox release decrease to 12 % in 55 % Pec microsphere formulation after 1-year storage at 4 °C. FTIR analysis of Pec?Dox complex showed hipsochromic shifts for the óC0O, äN-H and óC-C vibrational modes compared to Dox spectrum suggesting strong interaction between the drug cargo and the matrix. Rheological studies of Pec and Pec?Dox samples flow behavior exhibited a shear-thinning nature. Fifty-five percent of Pec showed higher viscosity than the viscosity for 35 % Pec in all range of temperatures analyzed, and decreased when the temperature is raised. Besides, Pec?Dox complexes have higher viscosity values than those of the corresponding Pec samples, and viscosity curves as function of shear rate for 35 % Pec?Dox are above the curves of 55 % Pec?Dox. In both cases, the results are confirming significant interaction between the cargo and the matrix, which also was established in viscoelastic dynamic analysis.","palabras_clave":"DRUG DELIVERY|DOXORUBICIN|PECTIN|FTIR|RHEOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3213,"idioma_id":4,"titulo":"C1272F: a novel type 2A von Willebrand?s disease mutation in A1 domain; its clinical significance","resumen":"Introduction: Most mutations identified in 2A VWD patients are localized in the A2 domain, although missense substitutions have also been recognized in the A1 domain. Objective: to describe a novel heterozygous missense mutation in the A1 domain of VWF gene responsible of type 2A phenotype. Patients and methods: analysis of the complete exon 28 was carried out in a patient and his mother with life-long histories of moderate-severe bleeding and laboratory data of type 2A VWD. The analysis of exon 28 of VWF gene showed a 3815 G-T transversion resulting in C1272F mutation. It is probably associated with a group I mechanism according to patients´s clinical symptoms, and, in the case of the propositus, the lack of clinical response to treatment with desmopressin. The mutation was not found in 100 normal alleles. Discussion: This substitution affected the normal S-S bound between C1272¨CC1458, which is involved in A1 loop structure, altering the normal multimerization, and function of VWF. The VWFpp\/VWF:Ag ratio in the propositus and his mother was >3, suggesting a shortened survival of VWF. We believe it is important to report the complete clinical phenotype corresponding to the new mutation in order to increase the knowledge in the clinical field.","palabras_clave":"C1272F|TYPE 2A VWD|CLINICAL SIGNIFICANCE|A1 VWF DOMAIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3215,"idioma_id":4,"titulo":"Structural, spectral and potentiometric characterization and antimicrobial activity studies of the new Zn(II) complex: [Zn(phen)2(cnge)(H2O)](NO3)2.H2O","resumen":"An octahedral Zn complex with o-phenanthroline (o-phen) and cyanoguanidine (cnge) has been synthesized and characterized. The crystal structural data show the formation of a ZnN5O core where the metal coordinates to two mutually perpendicular o-phenanthrolines as bidentate ligands [Zn?N bond lengths in the 2.124(2)?2.193(2)&#8201;Å range], the cyanide nitrogen of a cnge [d(Zn?N)&#8201;=&#8201;2.092(2)&#8201;Å, (Zn?N?C)&#8201;=&#8201;161.1(2)°], and a water molecule [d(Zn?Ow)&#8201;=&#8201;2.112(2)&#8201;Å]. Spectral data (FT-IR, Raman, and fluorescence) and speciation studies are in agreement with the structure found in the solid state and the one proposed to exist in the solution. To evaluate the changes in the microbiological activity of Zn, antibacterial studies were carried out by observing the changes in minimum inhibitory concentration of the complex, the ligands, and the metal against five different bacterial strains. The antibacterial activity of Zn improved upon complexation in three of the tested strains.","palabras_clave":"O-PHENANTROLINE|CYANOGUANIDINE|CRISTAL STRUCTURE|ANTIBACTERIAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3216,"idioma_id":4,"titulo":"Development of corpus luteum susceptibility to an analog of Prostaglandin F2alfa, throughout the luteal phase in llamas (Lama glama)","resumen":"The aim of the present study was to evaluate the susceptibility of the corpus luteum to  d-cloprostenol (synthetic analog of PGF2) throughout the luteal phase in llamas. Female  llamas (n = 43) were induced to ovulate by GnRH injection in the presence of an ovulatory  follicle and randomly assigned into one of six groups: control and treated with an injection  of d-cloprostenol on Day 3, 4, 5, 6 or 8 post GnRH. Blood samples were collected to determine  plasma progesterone concentrations. There was no effect of treatment on animals injected  on Day 3 or 4 post-GnRH. In animals treated on Day 5, different responses were observed. No  effect of treatment was recorded in 27% of the animals whereas 55% of the llamas showed a  transitory decrease followed by a recovery in plasma progesterone concentrations after dcloprostenol  injection, indicative of a resurgence of the corpus luteum, extending the luteal  phase a day more than in control animals. In the remaining 18% of the animals injected on  Day 5, (corresponding to those exhibiting the greatest plasma progesterone concentrations  at the day of injection), complete luteolysis was observed. Plasma progesterone concentrations  decreased to below 1 ng ml&#8722;1 24 h after d-cloprostenol in llamas injected on Day  6 or 8 post-GnRH. In conclusion, the corpus luteum of llamas is completely refractory to  PGF2 until Day 4 after induction of ovulation, being partially sensitive by Day 5 and fully  responsive to PGF2, by Day 6 after induction of ovulation.","palabras_clave":"Corpus Luteum|Luteolysis|Prostaglandin|Llamas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3217,"idioma_id":4,"titulo":"Kinetic study of the combustion of ethanol and ethyl acetate mixtures over a MnCu catalyst","resumen":"A kinetic study of ethanol and ethyl acetate combustion on an efficient catalyst identified as Mn9Cu1 is  reported in this contribution. Ethanol and ethyl acetate are typical VOCs which can be found in effluents of  printing industries. Ethanol oxidation produces an intermediate product, acetaldehyde. On the other hand,  ethyl acetate oxidation produces directly CO2 and H2O. Acetaldehyde reacts more slowly than ethanol,  while ethyl acetate is slightly more difficult to oxidize than acetaldehyde.  Strong inhibition effects among the species involved (ethanol, ethyl acetate and acetaldehyde) should be explicitly  considered to propose reaction rate expressions. Thus, experimental data were satisfactorily fitted  employing LHHW type expressions. The estimated activation energy of ethyl acetate and ethanol oxidation  lies in the range of values reported in the literature for similar catalysts.  © 2011","palabras_clave":"VOCS|ETHYL ACETATE|ETHANOL|CATALYTIC COMBUSTION|kINETICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3218,"idioma_id":4,"titulo":"Fusarium wilt of cyclamens: Pathogenicity and vegetative compatibility groups structure of the pathogen in Argentina","resumen":"Cyclamen persicum is a winter flowering species, cultivated as a potted ornamental. It is an economically important crop in Argentina. Fusarium wilt caused by Fusarium oxysporum f. sp. cyclaminis (Foc)is a destructive disease that limits the production of quality plants. The aims of this work were to analyze Fusarium isolates from cyclamen crops in Argentina for pathogenicity and vegetative compatibility groups (VCGs) structure. As a result of crop surveys, 64 isolates of Fusarium oxysporum were obtained from cyclamen plants with typical wilt symptoms, cultivated in 13 locations in Buenos Aires and Córdoba provinces, Argentina. Pathogenicity of all the isolates was confirmed by two different methods of inoculation. Initial symptoms usually appeared 12e15 days after inoculation for both methods. All the isolates were identified as Foc. VCGs structure was determined by the complementation of nitrate- nonutilizing (nit) mutants as a visual indicator of heterokaryon formation. All the isolates were arranged in 5 VGC groups. The largest group (VCG1) included 53 isolates (83%) obtained from all of the different production areas and most commercial crops. The other VCGs were formed by 1e4 isolates obtained from 5 commercial crops. Our results suggest the existence of a uniform population of Foc in Argentina, which is widespread in geographically separated areas, since some locations are distant approximately 700 km. The distribution of members of the same VCG in distant areas would demon- strate that those pathogenic isolates have a common origin, and a close genetic relationship. Since the pathogen can be spread on seed coats and in seed debris, it?s introduction in Argentina with multiplication material seems possible.","palabras_clave":"FUSARIUM OXYSPORUM F. SP. CYCLAMINIS|PATHOGENICITY|VEGETATIVE COMPATIBILITY GROUPS|CYCLAMEN PERSICUM|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3219,"idioma_id":4,"titulo":"Solid-phase based synthesis of biologically promising triazolyl aminoacyl (peptidyl) penicillins","resumen":"An efficient and versatile methodology for the preparation of valuable triazolyl aminoacyl (peptidyl) penicillins is described. Solid-phase Cu(I)-catalyzed Hüisgen 1,3-dipolar cycloaddition was used as the key step showing general applicability and excellent regioselectivity either with CuI or [Cu(CH3CN)4]PF6 as Cu(I) source.","palabras_clave":"SOLID PHASE|TRIAZOLE COMPOUNDS|CLICK CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3220,"idioma_id":4,"titulo":"Plasmid Encoded AmpC (pAmpC) in Enterobacteriaceae: epidemiology of the  microorganisms and the resistance markers","resumen":"CMY-2 beta-lactamase is an important cause of beta-lactam resistance in Enterobacteriaceae and constitutes the most widespread pAmpC. Although CMY-2 has been previously recognized in our region, the real prevalence and epidemiology of this resistance marker was uncertain. During August-October 2009, we conducted a multicenter, prospective study to determine pAmpC prevalence and to characterize CMY-2 producing Escherichia coli associated plasmids. Plasmid-encoded AmpC prevalence was 0.9 % in enterobacteria in this period, being CMY-  2 prevalent and to a lesser extent DHA. Molecular typing of CMY-2- producing Escherichia coli isolates showed several lineages. Moreover, replicon typing of cmy-2- containing plasmids displayed a broad diversity in Inc\/cmy-2 links. Therefore, association of cmy-2 with specific transposon elements may be responsible for the spread of this resistance marker in Enterobacteriaceae","palabras_clave":"Plasmid encoded AmpC |CMY-2 beta-lactamase"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3221,"idioma_id":4,"titulo":"Modeling of CN-functionalized silica as vehicle for the delivery of the chemotherapeutic agent: cisplatin","resumen":"The adsorption of cisplatin and its complexes, cis-[PtCl(NH3)2]+ and cis-[Pt(NH3)2]2+, on a CN-functionalized SiO2(111) surface has been studied by the atom superposition and electron delocalization method. The adiabatic energy curves for the adsorption of the drug and its complexes on the delivery system were considered. Electronic structure and bonding analyses were also performed. The molecules are adsorbed on the functionalized surface resulting in a major absorption of the cis-[Pt(NH3)2]2+ complex. The molecule-surface interactions are strengthened due to the incorporation of the CN silane group. The most important bonds occur through Pt-C, Pt-N and Pt-Si interactions. Despite the new interactions, the functionalized carrier maintains its matrix properties after adsorption. The remarkable properties may be attributed to the small electronic structure changes in the Si-CN groups caused by the interaction with neighboring cisplatin molecules and the enhancement in Pt-bonding interactions due to the surface incorporation of the CN silane groups.","palabras_clave":"cic platin|siO2|silica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3222,"idioma_id":4,"titulo":"Synthesis and vibrational properties of trifluoromethyl trifluoromethanethiosulfonate and comparison with covalent sulfonates","resumen":"Trifluoromethyl trifluoromethanethiosulfonate, CF3SO2SCF3 was characterized by 13C NMR, 19F NMR, and vibrational spectroscopy. Infrared spectra of CF3SO2SCF3 were obtained for the gaseous and liquid phases, while the Raman spectrum was recorded for the liquid phase. The experimental data were complemented with quantum chemical calculations. Both experimental and theoretical data indicate that only one conformer, gauche, is possible by rotating around the S¨CS bond. This conformational preference was studied using the total energy scheme and natural bond orbital partition scheme. These results evidence that electron delocalization and especially LP Y(Y = S, O)¡ús* S(6) O(4,5) and LP O(4,5)¡ús*S(6) Y interactions play an interesting role in the reactivity of oxoesters and thioesters","palabras_clave":"QUANTUM CHEMICAL CALCULATIONS|INTERNAL ROTATIONAL BARRIER|FOURIER TYPE EXPANSION|NATURAL BOND ORBITAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3223,"idioma_id":5,"titulo":"Categorización del estado de conservación de las Serpientes","resumen":"A más de una década de la primera Lista Roja de herpetofauna amenazada propuesta por la Asociación Herpetológica Argentina (AHA 2000), se recategorizaron las serpientes a partir de nueva información taxonómica, biogeográfica y bio-ecológica, además de modificaciones metodológicas respecto a la evaluación anterior. Mediante la participación de 18 especialistas de toda la Argentina se reevaluaron 136 taxones de serpientes (130 en la anterior) incluyendo varios cambios taxonómicos (8 taxones nuevos para Argentina y 2 sinonimizados), obteniéndose como resultado la inclusión de 49 especies en la lista roja (5 En Peligro, 17 Amenazadas, 27 Vulnerables), 15 Insuficientemente Conocidas y 72 No Amenazadas. En relación con la categorización anterior de la AHA: un taxón descendió de Vulnerable a No Amenazado, 11 No amenazados y 4 Insuficientemente Conocidos fueron elevados a distintas categorías de amenaza, 7 taxones Vulnerables fueron elevados a Amenazados, un taxón fue elevado de Amenazado a En Peligro. De 8 taxones no evaluados en 2000, uno categorizó No Amenazado, 4 Insuficientemente Conocidos, uno Vulnerable y 2 Amenazados. Estas modificaciones son el resultado de: (1) Mayor información sistemática, biogeográfica y bio-ecológica disponible para la evaluación; (2) Cambios en cuanto a las presiones antrópicas sobre las especies o sus hábitats;(3) Modificaciones metodológicas que incluyeron instructivos para aplicar los conceptos, la discusión y consenso entre especialistas y el análisis de las incertidumbres.","palabras_clave":"CATEGORIZACION|TAXONOMIA|REPTILES|HISTORIA NATURAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3224,"idioma_id":4,"titulo":"Fosfomycin concentrations in epithelial lining &#64258;uid in weaning piglets","resumen":"Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by29 bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of30 disodium fosfomycin 15 mg\/kg intramuscularly (IM). The mean concentrations of31 fosfomycin in ELF were lower than those in plasma at all sampling time points.32 Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of33 penetration of fosfomycin into the ELF was determined by comparing the AUC0?8 in34 ELF with the AUC0?8 in serum. The ratio AUCELF \/ AUCserum was 0.15 ± 0.02. The Cmax35 in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg\/ml, respectively. Theseconcentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 3637 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the38 first antibiotic dosage when the pathogen?s MIC is covered for at least 60?70% of the39 dosing interval. Different authors have determined a fosfomycin MIC90 for40 Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg\/ml. Fosfomycin41 concentrations in ELF remained above the MIC90 value for Streptococcus during more42 than 8 h post IM administration of 15 mg\/kg in weaning piglets. However, additional43 studies should be carried out in the lungs of infected pigs.","palabras_clave":"FOSFOMYCIN|EPHITHELIAL LINING FLUID|PIGLETS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3225,"idioma_id":4,"titulo":"Adhesin Contribution to Nanomechanical Properties of the Virulent  Bordetella pertussis Envelope","resumen":"Adherence to a biological surface allows bacteria to colonize and  persist within the host and represents an essential first step in the  pathogenesis of most bacterial diseases. Consequently, the  physicochemical properties of the outer membrane in bacteria play a key  role for attachment to surfaces and therefore for biofilm formation. Bordetella pertussis  is a Gram-negative bacterium that colonizes the respiratory tract of  humans, producing whooping cough or pertussis, a highly infectious  disease. B. pertussis uses various adhesins exposed on its  surface to promote cell-surface and cell-cell interactions. The most  dominant adhesin function is displayed by filamentous hemagglutinin  (FHA). B. pertussis Tohama I wild-type (Vir +) strain and two defective mutants, an avirulent (Vir -) and a FHA-deficient (FHA -) B. pertussis  strains were studied by AFM under physiological conditions to evaluate  how the presence or absence of adhesins affects the mechanical  properties of the B. pertussis cell surface. Quantitative  information on the nanomechanical properties of the bacterial envelope  was obtained by AFM force-volume analysis. These studies suggested that  the presence of virulence factors is correlated with an increase in the  average membrane rigidity, which is largely influenced by the presence  of FHA. Moreover, for this system we built a nanoscale stiffness map  that reveals an inhomogeneous spatial distribution of Young modulus as  well as the presence of rigid nanodomains on the cell surface.","palabras_clave":"BIOLOGICAL SURFACES|BACTERIAL ADHESION|NANOMECHANICAL PROPERTIES|ATOMIC FORCE MICROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3226,"idioma_id":4,"titulo":"Spore morphology and wall ultrastructure of Anemia Swartz species (Anemiaceae) from Argentina","resumen":"Spores of Anemia species that grow in Argentina are studied. The country corresponds to the southern limit inthe distribution of the genus where nine species have been reported: Anemia australis, A. herzogii, A. myriophylla,Anemia species that grow in Argentina are studied. The country corresponds to the southern limit inthe distribution of the genus where nine species have been reported: Anemia australis, A. herzogii, A. myriophylla,Anemia australis, A. herzogii, A. myriophylla,A. phyllitidis var. phyllitidis, A. phyllitidis var. tweedieana, A. simplicior, A. tomentosa var. anthriscifolia,var. phyllitidis, A. phyllitidis var. tweedieana, A. simplicior, A. tomentosa var. anthriscifolia,A. tomentosa var. tomentosa and A. wettsteinii. The material was examined using light microscope (LM), scanningelectron microscope (SEM) and transmission electron microscope (TEM). The spores are trilete of42?114 ìm in equatorial diameter and 34?106 ìm in polar diameter. The exospore is 1.2?7 ìm thick, twolayered;and two different ornamentations are observed: narrow and parallel ridges bearing baculae separatedby wide and smooth grooves or parallel wide ridges with several ornamentations separated by narrow andsmooth grooves. The perispore is 0.2?1.1 ìm thick, two-layered, and it may be plane or echinate with echinaof variable sizes and shapes depending on the taxa analyzed. Perforations are also present on the perisporesurface. The differences found in exospore and perispore morphology and ultrastructure could be valuablecharacters for systematic, phylogenetic and paleobotanical purposes.var. tomentosa and A. wettsteinii. The material was examined using light microscope (LM), scanningelectron microscope (SEM) and transmission electron microscope (TEM). The spores are trilete of42?114 ìm in equatorial diameter and 34?106 ìm in polar diameter. The exospore is 1.2?7 ìm thick, twolayered;and two different ornamentations are observed: narrow and parallel ridges bearing baculae separatedby wide and smooth grooves or parallel wide ridges with several ornamentations separated by narrow andsmooth grooves. The perispore is 0.2?1.1 ìm thick, two-layered, and it may be plane or echinate with echinaof variable sizes and shapes depending on the taxa analyzed. Perforations are also present on the perisporesurface. The differences found in exospore and perispore morphology and ultrastructure could be valuablecharacters for systematic, phylogenetic and paleobotanical purposes.?114 ìm in equatorial diameter and 34?106 ìm in polar diameter. The exospore is 1.2?7 ìm thick, twolayered;and two different ornamentations are observed: narrow and parallel ridges bearing baculae separatedby wide and smooth grooves or parallel wide ridges with several ornamentations separated by narrow andsmooth grooves. The perispore is 0.2?1.1 ìm thick, two-layered, and it may be plane or echinate with echinaof variable sizes and shapes depending on the taxa analyzed. Perforations are also present on the perisporesurface. The differences found in exospore and perispore morphology and ultrastructure could be valuablecharacters for systematic, phylogenetic and paleobotanical purposes.?1.1 ìm thick, two-layered, and it may be plane or echinate with echinaof variable sizes and shapes depending on the taxa analyzed. Perforations are also present on the perisporesurface. The differences found in exospore and perispore morphology and ultrastructure could be valuablecharacters for systematic, phylogenetic and paleobotanical purposes.","palabras_clave":"ANEMIA|ANEMIACEAE|SPORES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3227,"idioma_id":4,"titulo":"Contenido Químico de soluciones  después de la irrigación del conducto radicular dentario","resumen":"Summary  During endodontic treatment, irrigation of the root canal makes it possible to remove remainders of the dentin tubules. The aim of this study was to evaluate the content of extracted irrigation solutions of root canals after pulpectomy in teeth with pulpitis and pulp necrosis, in order to determine those Enless  aggressive on root dentine. Work was performed on 80 unirradicular upper human teeth, with 1% NaClO, 17% EDTA, 1% Ca(OH)2, 0.2% chlorhexidine and distilled water. The content of three irrigations was aspired and pH, total proteins, hydroxiproline, calcium and phosphor were determined. pH of the solutions showed no significant changes. A greater protein concentration was obtained with NaClO from teeth with necrosis and with EDTA from teeth with pulpitis; the greatest number of electrophoretic bands were revealed with EDTA. The hydroxiproline content was greater with Ca(OH)2 and with chlorhexidine, and that of phosphor was greater with EDTA and with NaClO for both types of teeth. Calcium was detected with NaClO and chlorhexidine. There were no different results between teeth with pulpitis and those with pulp necrosis in all chemical determinations. NaClO and EDTA solutions were effective in the elimination of organic rests from the root canal. Nevertheless, NaClO also eliminated calcium and phosphor, and the EDTA solution eliminated phosphor, possibly originated from hydroxiapatite and from protein complexes of dentin.","palabras_clave":"VITAL HUMANDENTAL PULP|NECROTIC HUMAN DENTAL PULP|ENDODONTIC IRRIGATION SOLUTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3228,"idioma_id":4,"titulo":"Detection of neutrinos from microquasares.II","resumen":"Using the neutrino intensity obtained from models for high-energy particle-emissionfrom low-mass micro-quasars, we calculate the neutrino flux with and without includingneutrino oscillations. We show that the neutrino flux from a micro-quasar is affected byneutrino oscillations. The effect reflects upon the increase in the time of observation, forkm-scale neutrino detector.1.","palabras_clave":"Neutrinos|Microquasars"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3286,"idioma_id":4,"titulo":"HANDLING CONSTRAINTS WITH AN EVOLUTIONARY TOOL FOR SCHEDULING OIL WELLS MAINTENANCE VISITS","resumen":"Oil exploitation and transportation are very important activities for the development of industrial society. However, these activities are generating risks that are translated into accidental or chronic contaminations that directly affect the ecosystem. It is important that oil companies carry out correct maintenance of their oil fields. For example, the scheduling of visits to oil wells is a critical problem that has to be addressed in this scenario. To do that, an efficient tool called PAE was formerly proposed that is based on an evolutionary algorithm which obtains better schedules than those obtained by experts. In this article, an extension of PAE is presented to solve a constrained version of the maintenance problem. This new version of PAE is studied under the application of a set of constraint-handling techniques based on penalty functions and repair algorithms. The results and comparisons demonstrated that PAE, using a repair algorithm, required less computational effort (evaluations) with the same quality of solutions for the set of instances used. Details of implementation, results and benefits are presented.","palabras_clave":"METAHEURISTICAS|LOCACIONES PETROLERAS|OPTIMIZACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3291,"idioma_id":4,"titulo":"IMMUNOGLOBULIN G FROM BREAST CANCER PATIENTS REGULATES MCF7 CELLS MIGRATION, ADHESION AND MMP-9 ACTIVITY BY STIMULATING MUSCARINIC ACETYLCHOLINE RECEPTORS","resumen":"IMMUNOGLOBULIN G FROM BREAST CANCER PATIENTS REGULATES MCF7 CELLS MIGRATION, ADHESION AND MMP-9 ACTIVITY BY STIMULATING MUSCARINIC ACETYLCHOLINE RECEPTORS  Abstract  PURPOSE:  We have previously reported the expression of muscarinic acetylcholine receptors (mAChR) in human breast tumors. The activation of these receptors triggered tumor cell proliferation. Considering that invasion and metastasis is the major cause of death in cancer, we investigated the action of autoantibodies against mAChR derived from breast cancer patients in stage I (T1N0Mx-IgG) on MCF-7 cells migration and metalloproteinase-9 (MMP-9) activity. We also analyzed the participation of phospholipase C\/nitric oxide synthase\/protein kinase C pathway.  METHODS:  Immunoglobulin G (IgG) was purified by chromatography in protein G-agarose from blood samples of breast cancer patients obtained under informed consent. Migration was assayed by an in vitro wound assay. MMP-9 activity was quantified by zymography.  RESULTS:  T1N0Mx-IgG promoted tumor cell migration and increased MMP9 activity mimicking the action of the muscarinic agonist carbachol. This effect was reduced not only by the presence of atropine but also by 4-DAMP or tropicamide, antagonists for M(3) and M(4) mAChR subtypes respectively. The actions of T1N0Mx-IgG and carbachol on MCF-7 cells, involved the participation of phospholipase C\/nitric oxide synthase\/protein kinase C pathway.  CONCLUSIONS:  IgG from breast cancer patients in stage I could be promoting tumor progression by regulating migration and MMP-9 activity in tumor cells via mAChR activation. The presence of these autoantibodies could be determining the prognosis of breast cancer in these patients.","palabras_clave":"autoantibodies|breast cancer|muscarinic acetylcholine receptors|tumor cell migration"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3296,"idioma_id":5,"titulo":"Libro del Apeo del Monasterio de Santo Toribio de Liébana (año 1499). Segunda Parte.","resumen":"Los libros de apeo son inventarios realizados por el titular del señorío, o su delegado, que tienen como objetivo fijar por escrito los bienes y derechos poseídos en un amplio espacio. Los testimonios juramentados de los vecinos del lugar y la fe pública otorgada por el letrado interviniente le otorgan al documento un indudable valor en juicio, aspecto que lo convierte en una herramienta eficiente para el resguardo de los intereses del señor.  Los datos contenidos en los apeos son múltiples y de una riqueza indudable para el investigador, en tanto describen la cantidad y tipo de bienes que posee el cenobio, su distribución espacial, la forma de explotación, la modalidad de concesión, la titularidad del censista, el monto y la naturaleza de la renta exigida, las exacciones que recaen sobre los vasallos, etc. Toda esta información puede dibujar una instantánea bastante precisa del dominio monástico, aunque nunca ajustada del todo a la realidad.","palabras_clave":"Documentación medieval|Transcripción|Santo Toribio de Liébana|Apeo 1499"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3297,"idioma_id":4,"titulo":"Determination of indoor air quality in archives and the biodeterioration of the documentary heritage","resumen":"  Documentary heritage is permanently subject to suffering from physical, chemical, and\/or biological alterations. Biological   deterioration by microorganisms (bacteria and fungi) causes undesirable changes on material properties. Microorganisms affect   different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.        different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.          deterioration by microorganisms (bacteria and fungi) causes undesirable changes on material properties. Microorganisms affect   different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.        different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.          ffering from physical, chemical, and\/or biological alterations. Biological   deterioration by microorganisms (bacteria and fungi) causes undesirable changes on material properties. Microorganisms affect   different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.        different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.        ffect   different organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.      fferent organic, natural or synthetic substrates (cellulose, polycarbonates), metals, and compounds of optical and magnetic   devices (CD, VHS). Paper made by vegetal fibers, functional additives (glue, optical polishers, consolidating agents), and inks with  organic bindings are used as sources of nutrients. The environmental microorganisms that formthe microbial charge of indoor air  at repositories (archives, libraries) storing cultural heritage can deteriorate the different supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.    fferent supports of heritage importance and affect   human health as allergies and skin affections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.  ffections. The aims of this research were to study microbial contamination of the environment   and its influence on biodeterioration by the biofilm formation and to analyze the relationship between environment microbiota  and biofilm formation in materials stored at three archives in Argentina and in two repositories of the National Archive of the  Republic of Cuba.","palabras_clave":"Air|Microorganisms|Archives|Paper"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3298,"idioma_id":4,"titulo":"Deformation and Fracture Behaviors of Vinylester\/Fly Ash Composites","resumen":"In this work, the deformation and fracture behavior of a commercial vinylester resin reinforced with fly ash was investigated. Tensile, compressive and fracture tests were performed on the matrix and the composites with different ash content. Most composites exhibited improved stiffness, tensile strength and fracture properties in comparison to the vinylester matrix. From SEM analysis of fracture surfaces, the toughening mechanisms of crack pinning, crack deflection, particle debonding and localized shear yielding were identified. In addition, the dependence of tensile and compressive modulus and fracture energy towards ash content was adequately fitted by simple models available in the literature. From the results of these models and EDS analysis, some interaction between vinylester and ash seemed to exist.","palabras_clave":"composite|fracture|mechanical properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3299,"idioma_id":4,"titulo":"\u2022\tStereoselective, solid phase-based synthesis of trans 3-alkyl-substituted beta-&#61485;lactams as analogues of cholesterol absorption inhibitors.","resumen":"A straightforward solid phase-based strategy for the rapid generation of two small libraries of trans 3-  alkyl-substituted b-lactams is described. For the glycine-derived library, a controlled excess of nonactivated acid chlorides was used to prevent oxazinone formation. The second library involved the attachment of Fmoc-protected p-aminophenol to Wang resin for the preparation of structurally-closed analogues of known cholesterol absorption inhibitors. This strategy allowed us to introduce diversity in the three variable positions of the beta-lactam ring.","palabras_clave":"solid-phase synthesis|beta-lactams|Cholesterol absorption inhibitors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3300,"idioma_id":4,"titulo":"Chemical Composition, Anti-Insect and Antimicrobial Activity of the Baccharis darwinii  Essential Oil from Argentine Patagonia","resumen":"Essential oils (EO) are interesting alternatives to synthetic agents for crops and health protection. This is the firsttime the composition, potential anti-insect activities and antifungal properties ofthe essential oil from Baccharis darwinii collected in Patagonia, Argentina, are reported. It would affect Ceratitis capitata, ?Mediterranean Fruit Fly,? and Triatoma infestans, Chagas disease vector, and would work as a source of antifungals to treat microbial infections. The chemical composition of the essential oils obtained byhydro-distillation from the aerial parts was analyzed by GC and GC\/MS. Forty components were identified, representing 97.2% of the total oil. The major components with recognized anti-insect and antimicrobial activity were limonene (47.1%), thymol (8.1%) and, 4-terpinelol (6.4%). The in vitro evaluation of theanti-insect properties showed promising insecticidal activity against C. capitata (LD50 19.9?31.0 g\/fly for males and females respectively at 72 h) and repellent activity against T. infestans (average repellence 92%). In addition, the oil exhibited strong antifungal activity against yeast and dermatophytes of clinical relevance, including some fungi such as Candida spp and Trichophyton spp with MIC values between 62.5 and 125 g\/mL.","palabras_clave":"Baccharis darwinii|Antifungal activity|Anti-insect activity|Essential oil|Triatoma infestans|Ceratitis capitata"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3301,"idioma_id":4,"titulo":"Monte Carlo simulation of enantioseparation process","resumen":"By means of Monte Carlo simulation, a study of enantioseparation by capillary electrophoresis has been carried out. A simplified system consisting of two enantiomers S (R) and a selector chiral C, which reacts with the enantiomers to form complexes RC (SC), have been considered.  The dependence of &#956; (enantioseparation) with the concentration of chiral selector and with the temperature have been analyzed by using the simulation. The effect of the binding constant and the charge of the complexes are also analyzed. The results are qualitatively satisfactory, despite the simplicity of the model.","palabras_clave":"MONTECARLO SIMULATION|ENANTIOSEPARATION|CAPILLARY ELECTROPHORESIS|CHIRAL SELECTOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3302,"idioma_id":4,"titulo":"IQGAP1: a microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity","resumen":"In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.","palabras_clave":"IQGAP|NEURON|MICROTUBULES|DEVELOPMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3303,"idioma_id":4,"titulo":"Evaluation of the effect of cooling and of the addition of collagenase on llama sperm DNA using toluidine blue","resumen":"The effect cryopreservation has on sperm chromatin condensation has been studied in many species but not in South American Camelids. The objectives of this study were to evaluate with toluidine blue (TB) the effects of cooling and of adding collagenase on llama sperm DNA condensation. The optimum incubation time (30 seconds, 1.5 and 3 minutes) with a reducing agent (dithiothreitol) was also determined. When comparing cooled samples with the raw ejaculate, a significant increase in sperm showing a high degree of decondensation (TB positive) was observed (P=0.005). A positive correlation was observed, both in raw and cooled semen, between sperm head morphological abnormalities observed in TB stained cells and TB positive sperm (highly decondensed DNA), but not with TB intermediate spermatozoa (moderately decondensed DNA). No significant differences (P&gt;0.05) were observed in samples incubated with or without 0.1% collagenase. In cooled semen, but not in raw, a significant increase (P=0.000) in reacted sperm was observed using 3 minutes incubation with 1% dithiothreitol (DTT). To conclude, cooling would seem to produce an increase in llama sperm chromatin decondensation. Also, 0.1% collagenase in H-TALP-BSA could be added to raw semen to aid its manipulation as it would not seem to increase DNA decondensation.","palabras_clave":"COLLAGENASE|COOLED SEMEN|DNA|LLAMA|TOLUIDINE BLUE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3304,"idioma_id":4,"titulo":"The sylvatic transmission cycle of Trypanosoma cruzi in a rural area in the humid Chaco of Argentina","resumen":"Little is known about the sylvatic transmission cycle of Trypanosoma cruzi in the Gran Chaco ecoregion. We conducted surveys to identify the main sylvatic hosts of T. cruzi, parasite discrete typing units and vector species involved in Pampa del Indio, a rural area in the humid Argentinean Chaco. A total of 44 mammals from 14 species were captured and examined for infection by xenodiagnosis and polymerase chain reaction amplification of the hyper-variable region of kinetoplast DNA minicircles of T. cruzi (kDNAPCR). Ten (22.7%) mammals were positive by xenodiagnosis or kDNA-PCR. Four of 11 (36%) Didelphis albiventris (white-eared opossums) and six of nine (67%) Dasypus novemcinctus (nine-banded armadillos) were positive by xenodiagnosis and or kDNA-PCR. Rodents, other armadillo species, felids, crab-eatingraccoons, hares and rabbits were not infected. Positive animals were highly infectious to the bugs that fed upon them as determined by xenodiagnosis. All positive opossums were infected with T. cruzi I and all positive nine-banded armadillos with T. cruzi III. Extensive searches in sylvatic habitats using 718 Noireau trap-nights only yielded Triatoma sordida whereas no bug was collected in 26 light-trap nights. Four armadillos or opossums fitted with a spool-and-line device were successfully tracked to their refuges; only one Panstrongylus geniculatus was found in an armadillo burrow. No sylvatic triatomine was infected with T. cruzi by microscopical examination or kDNA-PCR. Our results indicate that two independent sylvatic transmission cycles of T. cruzi occur in the humid Chaco. The putative vectors of both cycles need to be identified conclusively.","palabras_clave":"Trypanosoma cruzi|sylvatic cycle|Didelphis albiventris|Dasypus novemcinctus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3305,"idioma_id":4,"titulo":"Development of an experimentally induced Streptococcus uberis subclinical mastitis in goats","resumen":"Streptococcus Uberis is the major environmental mastitis-causing pathogen","palabras_clave":"MASTITIS |STEPTOCOCCUS UBERIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3306,"idioma_id":5,"titulo":"IMPACTO DE DIETAS CON ALTO CONTENIDO EN GRASA SOBRE EL PERFIL DE L&Iacute;PIDOS S&Eacute;RICOS: ESTUDIO EN RATAS EN CRECIMIENTO","resumen":"La importancia de la cantidad y el equilibrio de los lípidos en la dieta sobre el progreso de la enfermedad cardiovascular y la obesidad es ampliamente aceptada. El objetivo de este trabajo fue analizar el efecto de dietas con alto contenido en grasas sobre los niveles séricos de triglicéridos (TG), colesterol total (CT), colesterol de HDL (HDL-Col) y el perfil de acidos grasos de ratas en periodo de crecimiento. Ratas Wistar al destete fueron alimentadas con dietas cuyas fuentes lipídicas fueron: manteca + manteca de cacao (Grupo S); aceite de oliva + aceite de soja (Grupo M) y F%=40, administradas durante 10 y 40 días. El grupo control (C) recibió dieta normocalórica. Se determinó la concentración de TG, CT y HDL-Col por método enzimático-colorimétrico y el perfil de ácidos grasos por cromatograf¨ía gaseosa. El grupo S presentó aumento estadísticamente significativo en la concentración de los TG vs los otros grupos a los 10 y 40 días. No se encontraron diferencias en la concentración de CT y HDL-Col entre los grupos. Cuando las dietas se administraron durante 10 días, los niveles de ácido oleico en S y M fueron superiores a C. A los 40 días de la alimentaci¨®n, el grupo S presentó aumento de ácido oleico y disminución de ácido linoleico. Estos resultados representan una posible respuesta a las diferencias en el perfil de ácidos grasos de las fuentes utilizadas y en el porcentaje de grasa aportado por las dietas al exacerbar la vía de la familia &#969;9. . ","palabras_clave":"triglicéridos|colesterol|ácidos grasos|dieta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3307,"idioma_id":5,"titulo":"El estudio de la Resiliencia y Calidad de Vida en distintas transiciones ecológicas humanas","resumen":"El presente trabajo tiene por objetivo presentar los avances investigativos obtenidos al estudiar diversas problemáticas referidas a las áreas de salud, educación y justicia, desde el marco de la Resiliencia y la Calidad de Vida. El eje de análisis en estas áreas comprende el estudio de aquellos factores de riesgo y de protección que interactúan otorgando características específicas a cada una de las transiciones ecológicas estudiadas. Se analizan la discapacidad motora, el proceso de morir cuando la enfermedad ya no responde a las medidas curativas, la internación del recién nacido en la Unidad de Cuidados Intensivos Neonatológicos, la transición por la que atraviesan los jóvenes al pasar del nivel primario al secundario, y la privación de libertad. Por transiciones ecológicas se entiende los cambios en la posición de una persona dentro del ambiente ecológico en el que está inmersa, como consecuencia de un cambio de rol, de entorno, o de ambos a la vez (Bronfenbrenner, 1987).  El desafío será entonces, desde el enfoque señalado, valorar en cada situación, la eficacia y funcionalidad de los recursos y factores presentes, así como también, aquellos que pueden ser promovidos a través de estrategias que revaloricen el Potencial Resiliente y la Calidad de Vida de cada persona frente a la adversidad.","palabras_clave":"Resiliencia|Calidad de Vida|Tranciciones Ecológicas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3308,"idioma_id":4,"titulo":"Effect of the sequence of impregnation on the activity and sulfur resistance of Pt-Ni\/g-Al2O3 bimetallic catalysts for the selective hydrogenation of styrene","resumen":"The influence of the preparation on the activity and sulfur resistance of bimetallic Pt-Ni catalysts for styrene semi-hydrogenation was studied. Preparation variables assessed were the sequence of impregnation and the kind of nickel precursor used. The catalysts were tested in reaction and further characterized by the techniques of ICP, TPR, XPS and pyridine TPD.  All catalysts showed high selectivities to ethylbenzene (> 98%). Bimetallic catalysts were more active than the monometallic one and the following activity order was found: Pt &#61504; NiClPt < NiNPt < PtNiCl < PtNiN. After poisoning with 300 ppm of thiophene the following order of sulfur resistance was found:  PtNiCl < Pt < PtNiN < NiClPt < NiNPt.  Differences in activities and sulfur resistance between the catalysts were atributed to electronic effects related to the presence of different electron-rich and electron-deficient surface species of Pt and Ni on the surface that interact between themselves and with the support. The bimetallic catalyst with the highest Cl\/Pt atomic ratio on the surface (as obtained by XPS) proved to be the most sulfur resistant;  this higher poison resistance was rationalized in terms of both steric and electronic effects.","palabras_clave":"SELECTIVE HYDROGENATION|BIMETALLIC CATALYSTS|SULFUR RESISTANCE|PLATINUM; NICKEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3310,"idioma_id":4,"titulo":"Pharmacokinetics of sodium and trihydrate amoxicillin alter intravenous and intramuscular administration in llamas (Lama glama)","resumen":"Abstract: The pharmacokinetics of amoxicillin following a single intravenous (i.v.) and intramuscular  (i.m.) administration of a conventional sodium formulation and following a single i.m. administration  of a trihydrate long acting suspension was investigated in adult llamas. On phase 1, in a cross-over  design, six llamas received sodium amoxicillin (20 mg\/kg) by the i.v. and i.m. routes. On phase 2, six  llamas received i.m. trihydrate amoxicillin suspension (15 mg\/kg). Amoxicillin plasma concentrations  were determined using a microbiological assay. Significant differences were found for mean maximum  concentration (40.4 ± 12.1 vs 3.04 ± 1.02 &#956;g\/ml), mean elimination half-life (0.86 ± 0.3 vs 9.96 ± 3.1 h)  and mean residence time (1.37 ± 0.5 vs 15.1 ± 4.1 h) following sodium and trihydrate i.m. amoxicillin,  respectively. Bioavailability was similar for both sodium (1.44 ± 0.2) and trihydrate (1.14 ± 0.4)  formulations. The results of the pharmacokinetic\/pharmacodynamic indices of time above the minimal  inhibitory concentrations (T>MIC) suggest that 20 mg\/kg sodium amoxicillin would produce a good  therapeutic outcome in infections due to susceptible bacteria administered every 8-12 h, while for 15  mg\/kg trihydrate amoxicillin, higher doses or more frequent intervals may be needed for treating low  susceptibility bacteria in llamas.","palabras_clave":"Antibiotics|llamas|amoxicillin|Pharmacokinetics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3312,"idioma_id":4,"titulo":"Expression differential of microsomal and cytosolic glutathione-S-transferases in Fasciola hepatica resistant at triclabendazole","resumen":"In the present work, we evaluate in vitro the cytosolic and microsomal activity of glutathione-S-transferases in adults of Fasciola hepatica susceptible (Cullompton Strain) and resistant (Sligo Strain) to triclabendazole. The triclabendazole resistant (Sligo) fluke expressed significant major metabolic activity of glutathione-S-transferases compared to that measured in the cytosolic and microsomal fractions obtained from susceptible flukes (Cullompton Strain). The results associated with previous data where the Sligo Strain overexpress Flavin Monooxigenase confirm a multienzymatic response involving more than one metabolic pathway.","palabras_clave":"FASCIOLA HEPATICA|TRICLABENDAZOLE|METABOLIC ACTIVITY|GLUTATHIONE-S-TRANSFERASES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3313,"idioma_id":5,"titulo":"RELACIÓN ENTRE LA VARIABILIDAD ESPACIAL DE LA CONDUCTIVIDAD ELÉCTRICA Y EL CONTENIDO DE SODIO DEL SUELO","resumen":"La agricultura de precisión utiliza herramientas modernas capaces de facilitar la obtención y análisis de datos georreferenciados. La conductividad eléctrica aparente (CEa) del suelo, se obtiene con sensores remotos y está correlacionada con algunas propiedades del suelo (capacidad de almacenamiento de agua, contenido de materia orgánica, salinidad y drenaje, topografía, manejos previos y texturas entre otras). El exceso de sales puede ser perjudicial para las plantas mientras que altos contenidos de sodio intercambiable pueden provocar daños físicos y químicos en el suelo, afectando el crecimiento de los cultivos. Se seleccionaron 3 lotes con una superficie promedio de 80 ha, regados con pivote central, en el sudeste de la provincia de Buenos Aires, Argentina. En cada lote se midió la CEa georreferenciada con un sensor de medición directa. Con los datos obtenidos se confeccionaron mapas de CEa utilizando técnicas de interpolación espacial (Kriging). Los campos fueron divididos en zonas de igual rango de CEa, para tomar muestras de suelo en las que se midió humedad gravimétrica (&#952;g), CE del extracto de saturación (CEe) y cationes solubles (Na+, Ca+2 y Mg+2). Se calculó la relación de adsorción de sodio (RAS). Los datos fueron analizados estadísticamente utilizando el procedimiento PROC MIXED de SAS. Se observó variabilidad espacial de la CEa y se detectó una asociación entre la CEa y el RAS. Existe una relación significativa entre la CEa, la CEe y el contenido de sodio del suelo, diferenciándose estadísticamente los contenidos de Na+ entre las diferentes zonas de CEa de cada lote. Los sensores de medición directa de CEa son herramientas eficaces para la estimación espacial del contenido de sodio del suelo. a) del suelo, se obtiene con sensores remotos y está correlacionada con algunas propiedades del suelo (capacidad de almacenamiento de agua, contenido de materia orgánica, salinidad y drenaje, topografía, manejos previos y texturas entre otras). El exceso de sales puede ser perjudicial para las plantas mientras que altos contenidos de sodio intercambiable pueden provocar daños físicos y químicos en el suelo, afectando el crecimiento de los cultivos. Se seleccionaron 3 lotes con una superficie promedio de 80 ha, regados con pivote central, en el sudeste de la provincia de Buenos Aires, Argentina. En cada lote se midió la CEa georreferenciada con un sensor de medición directa. Con los datos obtenidos se confeccionaron mapas de CEa utilizando técnicas de interpolación espacial (Kriging). Los campos fueron divididos en zonas de igual rango de CEa, para tomar muestras de suelo en las que se midió humedad gravimétrica (&#952;g), CE del extracto de saturación (CEe) y cationes solubles (Na+, Ca+2 y Mg+2). Se calculó la relación de adsorción de sodio (RAS). Los datos fueron analizados estadísticamente utilizando el procedimiento PROC MIXED de SAS. Se observó variabilidad espacial de la CEa y se detectó una asociación entre la CEa y el RAS. Existe una relación significativa entre la CEa, la CEe y el contenido de sodio del suelo, diferenciándose estadísticamente los contenidos de Na+ entre las diferentes zonas de CEa de cada lote. Los sensores de medición directa de CEa son herramientas eficaces para la estimación espacial del contenido de sodio del suelo. ","palabras_clave":"Georreferenciación y Riego|Sensor|Agricultura de Precisión|Sodificación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3375,"idioma_id":4,"titulo":"Jet energy resolution in proton-proton collisions at sqrt(s) = 7 TeV recorded in 2010 with the ATLAS detector","resumen":"The measurement of the jet energy resolution is presented using data recorded with the ATLAS detector in proton-proton collisions at s&#8730;=7 TeV . The sample corresponds to an integrated luminosity of 35 pb&#8722;1. Jets are reconstructed from energy deposits measured by the calorimeters and calibrated using different jet calibration schemes. The jet energy resolution is measured with two different in situ methods which are found to be in agreement within uncertainties. The total uncertainties on these measurements range from 20 % to 10 % for jets within |y|<2.8 and with transverse momenta increasing from 30 GeV to 500 GeV. Overall, the Monte Carlo simulation of the jet energy resolution agrees with the data within 10 %.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3384,"idioma_id":4,"titulo":"Self-medication In Ophthalmology In An Argentinean Population: A Questionnaire-based Study","resumen":"Abstract  PURPOSE:  The aim of this study was to identify practices of self-medication in the treatment of ocular conditions and to identify a profile of patients who self-medicate.    METHODS:  We conducted a cross-sectional descriptive survey of patients, over the age of 17 years seen in our ophthalmology practice in Cordoba, Argentina. Self-medication was defined as the use of ophthalmic medicines which had not been prescribed by a health care specialist in the previous year.    RESULTS:  The sample included 379 subjects, 162 males (43%) and 217 females (57%); mean age 46.8 years. Prior to looking for medical attention in our institution, 97 patients (25.6%) reported self-medicating. The most frequently employed products included non-steroidal anti-inflammatory drops in combination with a vasoconstrictive agent (32%) followed by a combination of antibiotics and steroids (9%), however, 14% of patients did not remember the name or type of medication applied. A total of 31% of patients used drugs recommended by a pharmacist; 25% used drugs of their own choosing and 24% followed suggestions from a friend or family member. Only 12% of patients knew the drug´s components and only 3% were aware of any possible side effects. There was no difference in behavior patterns related to educational level or age, however, there was a significant difference related to gender, with males misusing ophthalmic drops more frequently than women (P = 0.004).    CONCLUSIONS:  Patients commonly attempt to treat conditions that require ophthalmologic care by self-medicating with over-the-counter eye drops. Educational efforts to inform patients of the consequences of self-medication are necessary.","palabras_clave":"Argentina|Cultural habits|Over-the-counter drugs|Self-medication"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3385,"idioma_id":4,"titulo":"CALIFA, the Calar Alto Legacy Integral Field Area survey. II. First public data release","resumen":"The final product of galaxy evolution through cosmic time is the population of galaxies in the local universe. These galaxies are also those that can be studied in most detail, thus providing a stringent benchmark for our understanding of galaxy evolution. Through the huge success of spectroscopic single-fiber, statistical surveys of the Local Universe in the last decade, it has become clear, however, that an authoritative observational description of galaxies will involve measuring their spatially resolved properties over their full optical extent for a statistically significant sample. We present here the Calar Alto Legacy Integral Field Area (CALIFA) survey, which has been designed to provide a first step in this direction. We summarize the survey goals and design, including sample selection and observational strategy. We also showcase the data taken during the first observing runs (June\/July 2010) and outline the reduction pipeline, quality control schemes and general characteristics of the reduced data. This survey is obtaining spatially resolved spectroscopic information of a diameter selected sample of ~600 galaxies in the Local Universe . CALIFA has been designed to allow the building of two-dimensional maps of the following quantities: (a) stellar populations: ages and metallicities; (b) ionized gas: distribution, excitation mechanism and chemical abundances; and (c) kinematic properties: both from stellar and ionized gas components. CALIFA uses the PPAK integral field unit (IFU), with a hexagonal field-of-view of ~1.3 sqr´, with a 100% covering factor by adopting a three-pointing dithering scheme. The optical wavelength range is covered from 3700 to 7000 Å, using two overlapping setups (V500 and V1200), with different resolutions: R ~ 850 and R ~ 1650, respectively. CALIFA is a legacy survey, intended for the community. The reduced data will be released, once the quality has been guaranteed. The analyzed data fulfillthe expectations of the original observing proposal, on the basis of a set of quality checks and exploratory analysis: (i) the final datacubes reach a 3sigma limiting surface brightness depth of ~23.0 mag\/arcsec2 for the V500 grating data (~22.8 mag\/arcsec2 for V1200); (ii) about ~70% of the covered field-of-view is above this 3sigma limit; (iii) the data have a blue-to-red relative flux calibration within a few percent in most of the wavelength range; (iv) the absolute flux calibration is accurate within ~8% with respect to SDSS; (v) the measured spectral resolution is ~85 km s-1 for V1200 (~150 km s-1 for V500); (vi) the estimated accuracy of the wavelength calibration is ~5 km s-1 for the V1200 data (~10 km s-1 for the V500 data); (vii) the aperture matched CALIFA and SDSS spectra are qualitatively and quantitatively similar. Finally, we show that we are able to carry out all measurements indicated above, recovering the properties of the stellar populations, the ionized gas andthe kinematics of both components. The associated maps illustrate the spatial variation of these parameters across the field, reemphasizing the redshift dependence of single aperture spectroscopic measurements. We conclude from this first look at the data that CALIFA will be an important resource for archaeological studies of galaxies in the Local Universe.  Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck-Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).","palabras_clave":"techniques: spectroscopic|Galaxy: general, surveys"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3386,"idioma_id":4,"titulo":"Free energies as invariants of Teichmuller like structures","resumen":"A Teichmuller like structure on the space of d-degree holomorphic maps on the circle S¹, marked by conjugations to the map of z into Zd, can be defined. Here we introduce a definition of free energy associated to this kind of dynamics as an invariant of equivalence classes in the Teichmuller space. This quantity encodes a length spectrum of rotation cycles in S¹.","palabras_clave":"FREE ENERGY|CIRCLE MAP|TEICHMULLER SPACE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3387,"idioma_id":5,"titulo":"EL PRINCIPIO DE NO REGRESION EN EL DERECHO AMBIENTAL: ANÁLISIS Y PROPUESTAS EN EL CASO DEL CÓDIGO DE REDES EN EL MUNICIPIO DE CORRIENTES","resumen":"El articulo analiza el principio de no regresión, en relacion con el derecho ambiental, en particular en relación con el código de redes del municipio de la ciudad de Corrientes.","palabras_clave":"PRINCIPIOS|NO REGRESION|AMBIENTE|ENERGIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3388,"idioma_id":5,"titulo":"Transporte, movilidad y desarrollo territorial. El caso de la reactivación ferroviaria del ramal Paraná ? Concepción del Uruguay, Entre Ríos, Argentina. 2009 ? 2011","resumen":"Considerando un enfoque integral respecto al territorio y su imbricación con lo social surge la necesidadde plantearse como es posible conducir las propias dinámicas del territorio hacia el desarrollo. El artículopresenta una experiencia de investigación llevada a cabo en la Provincia de Entre Rios, Argentina, en elmarco de un proyecto orientado al estudio del transporte, el ordenamiento y el desarrollo territorialprovincial mediante la reactivación de un ramal ferroviario de pasajeros. Se presenta el desarrollo de unsistema de información territorial y se expone el análisis de las características de la movilidad de lapoblación objeto de estudio mediante el desarrollo de tres tipologías de localidades (perfil socioinstitucional, perfil económico, y accesibilidad-conectividad) y la aplicación de una encuesta sobre lasnecesidades y demandas orientada al transporte ferroviario","palabras_clave":"MOVILIDAD|REACTIVACION|TERRITORIO|ENTRE RIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3389,"idioma_id":4,"titulo":"Evaluation of anti-Moraxella bovis pili immunoglobulin A in tears following intranasal vaccination of cattle","resumen":"Infectious bovine keratoconjunctivitis (IBK) is a highly contagious ocular disease of cattle caused byMoraxella bovis(Mb). Parenterally administered immunogens used to prevent the disease do not offercomplete protection possibly because they stimulate a poor ocular mucosal secretory response, in whichlocally secreted immunoglobulin-A (sIgA) is one of the main components. The principal aim of this studywas to evaluate by an indirect enzyme linked immunosorbent assay (ELISA), the local ocular mucosal sIgAresponse against Mb purified pili, produced after intranasal inoculation of experimental vaccines. Piliwere adjuvanted by several different adjuvants (QuilA, Marcol Arlacel, Marcol Span, microencapsulatedpili with PLGA polymers). Results were compared to sIgA response produced by adjuvant placebo inoculations and by IBK natural infection. Significantly higher anti-pili IgA response (p< 0.05) was detectedin calves vaccinated intranasally with pili QuilA and pili Marcol Span compared to control calves,although this specific immune response did not seem to be related to protection against Mb infectionor typical IBK lesion development.","palabras_clave":"MORAXELLA|KERATOCONJUNCTIVITIS|IGA|VACCINES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3390,"idioma_id":4,"titulo":"Superparamagnetic Nanocomposites Based on the Dispersion of Oleic Acid-Stabilized Magnetite Nanoparticles in a Diglycidylether of Bisphenol A-Based Epoxy Matrix: Magnetic Hyperthermia and Shape Memory","resumen":"Superparamagnetic nanocomposites were obtained by dispersion of oleic acid (OA)-coated magnetite NPs in an epoxy system based on diglycidylether of bisphenol A (DGEBA) modified with OA. Dispersion of conventional oleic acid stabilized magnetite NPs in a typical epoxy matrix is not possible due to the dissimilar chemical structures of the organic coating and the reactive solvent. However, by modification of a DGEBA-based epoxy with 20 wt% OA, we obtained a suitable reactive solvent to disperse up to at least 8 wt% of OA-stabilized magnetite NPs. A tertiary amine was used to catalyze the epoxy-acid reaction and initiate the homopolymerization of the epoxy excess. Both reactions occurred practically in series, first the epoxy-acid and then the epoxy homopolymerization. It was necessary to complete the first reaction to attain a very good dispersion of magnetite NPs in the reactive solvent previous to the occurrence of the final reaction. Magnetization curves and TEM images revealed a uniform dispersion of individual nanoparticles in the cross-linked epoxy. A sample containing 8 wt% OA-coated magnetite NPs exhibited a temperature increase of 25 °C at its surface when exposed to an alternating magnetic field. The temperature increase was enough to induce the shape memory effect of the nanocomposite.","palabras_clave":"superparamagnetic nanocomposites|shape memory polymers|Magnetic Hyperthermia|epoxy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3391,"idioma_id":4,"titulo":"Effect of co-cultivation of two Pleurotus species on lignocellulolytic enzyme production and mushroom fructification. International Biodeterioration and Biodegradation","resumen":"Co-cultivation of  mushroom species produce changes on fungal enzyme production and fructification  that were not in-depth studied hitherto. This work was conducted with the aim  of studying how the interactions between Pleurotus  ostreatus and Pleurotus citrinopileatus  in a dual culture affect the lignocellulolytic enzymes production, influence  yield values and modify the morphological properties of basidiomata obtained.  With this purpose monocultures of both species in a straw-based substrate were  investigated, as well as dual-cultures with 3 different spatial patterns (one  fungus in the upper portion of the bag and the second in the bottom, the  opposite spatial pattern, and a mix of spawn from both, scattered in each bag).  Co-cultivation did not increase basidiomata production, moreover, it inhibited carpophore  development of P. ostreatus in the  mix, and decreased basidiomata stem?s length significantly. Biological  efficiencies achieved in monocultures of P.  ostreatus and P. citrinopileatus  were 95.3% and 67.6% respectively. Different spatial patterns affected not only enzyme production but also  mycelial yield. Cellulolytic and xylanolytic activities detected increased  significantly when P. ostreatus was inoculated in the upper  portion of the bag and P. citrinopileatus  in the bottom part, but co-cultivation did not stimulate ligninolytic  enzyme production. The highest laccase (8.2 U g-1) and Mn-peroxidase  (7.5 U g-1) activities were detected in monocultures of P. ostreatus, in coincidence with  maximum lignin degradation (28%). ","palabras_clave":"CO-CULTIVATION|SPECIES INTERACTION|LIGNOCELLULOLYTIC  ENZYMES|MUSHROOM YIELD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3392,"idioma_id":4,"titulo":"Efectos del herbicida glifosato sobre la estructura y el funcionamiento de comunidades microbianas de dos suelos de plantaciones de olivo","resumen":"Los herbicidas pueden alterar la estructura y el funcionamiento del suelo mediante efectos directos sobre varios componentes de su microbiota. Muchos autores han encontrado un efecto perjudicial del glifosato sobre la calidad del suelo y la diversidad microbiana. Sin embargo, la mayoría de los trabajos han sido realizadosen sistemas de cultivos herbáceos y anuales y muy pocos en sistemas forestales o leñosos perennes. El objetivo del presente trabajo fue analizar el efecto a corto plazo de la aplicación de glifosato sobre parámetros microbiológicos generales y la estructura de las comunidades microbianas de suelos provenientes de lotes cultivados con olivo (Olea europaea L.). Realizamos un experimento de aplicación de distintas concentraciones de glifosato en dos tipos de suelo de olivar, con y sin historial de aplicación de pesticidas, y evaluamos distintas propiedades delsuelo a lo largo de 55 días de incubación. En general, el impacto del glifosato sobre la microbiota fue mucho más importante en el suelo sin historial de aplicación de herbicida. En la mayoría de los parámetros analizados, el tratamiento con glifosato a la concentración recomendada a campo no se diferenció del tratamiento control. Elcambio observado en la biomasa microbiana total no fue consistente. Sin embargo, en ambos suelos analizados, la aplicación de altas concentraciones de glifosato produjo un incremento signifi cativo de las bacterias cultivables y de las bacterias Gram (-), estimada por medio de perfi les de ácidos grasos.&nbsp;","palabras_clave":"pesticidas|microbiología de suelos|bacterias del suelo|Argentina|Roundup UltraMax"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3393,"idioma_id":4,"titulo":"Insulin sensitization with a peroxisome proliferator-activated receptor &#947; agonist prevents adrenocortical lipid infiltration and secretory changes induced by a high-sucrose diet.","resumen":"Patients  with chronic hypercortisolism display a cluster of abnormalities similar to  those detected in subjects affected by insulin resistance (IR), and it has been  hypothesized that deviations in glucocorticoid secretion and\/or action may  contribute to somatic and biochemical changes observed in patients with IR. We  analyzed changes in rat adrenocortical function and morphology associated to  the development of IR, generated in male adult rats by the addition of 30%  sucrose to the drinking water. Caloric intake, body and adipose tissue weights and  biochemical parameters were determined throughout the duration of this treatment.  Expression levels of StAR, CYP11A1, and MC2R were evaluated by RT-PCR, histochemical  analysis of the adrenal cortex was performed using Masson's trichrome and Sudan  III staining, and corticosterone levels were measured by RIA.                   After seven  weeks of sucrose administration higher serum glucose, insulin and triglyceride  levels and an altered glycemic response to an i.p. insulin test were detected. Adrenal  glands showed a neutral lipid infiltration (triglycerides + cholesterol). Furthermore,  sucrose-treated animals exhibited higher basal corticosterone levels and a  blunted response to ACTH injection. An increase in StAR and CYP11A1 and a  decrease in MC2R levels were also found. Noteworthy, the instauration of  adrenocortical (functional and histological) abnormalities was prevented in  sucrose-treated rats by the simultaneous administration of a PPAR-&#947; agonist.   Sucrose-induced  IR may affect adrenocortical function and morphology indirectly (altering  CRH\/ACTH secretion) or directly, by means of adipokines or lipid metabolites  generated within the adrenal gland. These abnormalities are prevented by the administration  of a PPAR&#947; agonist.","palabras_clave":"ADRENAL |INSULIN |CORTICOSTERONE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3394,"idioma_id":4,"titulo":"Post-Fire effects in wetland environment: Landscape assessment of plant coverage and soil recovery in the Paraná River Delta marshes, Argentina.","resumen":"During 2008, under a region-wide drought, there were a large number of simultaneous fires in the Paraná River Delta region: the most affected vegetation was in marshes dominatedby Schoenoplectus californicus (C.A.Mey.) Soják or Cyperus giganteus Vahl. The objective of this paper was to study fire severity in terms of fire effect on vegetation cover and soil properties, and the recovery of those properties after one growing season, using optical remote sensing techniques and fieldwork data. To this aim, we performed unsupervisedclassification of Landsat TM imagery and conducted vegetation censuses and soil sampling in November 2008 and May 2009. Our results show that we could identify three fire severity classes: low severity, medium severity, and high severity. These classes are characterized by a remnant vegetation cover of approximately 75 %, 25 %, and 5 %, respectively, and a diminution of soil organic carbon and nitrogen of 66 % and 59 % in the case of medium severity and high severity. Fire had almost no effect over pH and a slight effect on electrical conductivity. After one growing season, vegetation recovery is dependenton fire severity and hydrological condition, while soil properties did not show signs of recovery. This is one of the first studies of fire effects and recovery on fluvial herbaceouswetlands.","palabras_clave":"fire severity|fluvial wetlands|optical remote sensing|Parana river delta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3395,"idioma_id":4,"titulo":"Dynamics of adrenal steroids are related to variations in Th1 and Treg populations during different stages of Mycobacterium tuberculosis infection in HIV positive patients","resumen":"Tuberculosis (TB) remains the mostfrequent cause of illness and death from an infectious agent globally, and itsinteraction with HIV has devastating effects. &nbsp;We have explored the role of adrenal hormoneson the Th1 and Treg populations during different clinicalscenarios of HIV-TB coinfection, including the immune reconstitutioninflammatory syndrome (IRIS), a pro-inflammatory condition induced by antiretroviraltreatment.&nbsp; Dehydroepiandrosterone (DHEA)plasma levels were significantly diminished in HIV-TB and HIV-TB IRIS patientscompared to healthy donors (HD), &nbsp;HIV+individuals and HIV+ individuals with latent TB infection (HIV+LTB), whereas dehydroepiandrosteronesulfate (DHEA-s) levels were markedly diminished in HIV-TB IRIS individuals. Coinfectedpatients and IRIS patients presented a cortisol\/DHEA ratio significantly higherthan HIV+, HIV-LTB and HD individuals.&nbsp; Apositive correlation was observed between DHEA-s and CD4 count among HIV-TBindividuals.&nbsp; In contrast, cortisolplasma level was inversely correlated with CD4 count within HIV-TB individuals.&nbsp; Invitro assays showed that M.tuberculosis-specific Th1 lymphocyte count was increased after culturingPBMC from HIV-TB individuals in presence of DHEA.&nbsp; We observed an inverse correlation betweenDHEA-s plasma level and Treg frequency in co-infected individuals, andCD4+FoxP3+ Treg frequency was increased in HIV-TB and IRIS patients compared toother groups. &nbsp;Strikingly, we observed aprominent CD4+FoxP3+CD25- population across HIV-TB and HIV-TB IRIS patients,which frequency correlated with DHEA plasma level.&nbsp; Finally, DHEA treatment negatively regulatedFoxP3 expression without altering Treg frequency in co-infected patients. Thesedata support a role for DHEA in the immune response against HIV and M. tuberculosis during HIV-TBcoinfection and IRIS.","palabras_clave":"Neuroendocrine regulation|Tuberculosis-HIV co-infection|Cytokines|Adrenal hormones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3396,"idioma_id":4,"titulo":"Presynaptic Cav2.1 calcium channels carrying a familial hemiplegic migraine mutation r192q allow faster recovery from syanptic depression in mouse calyx of held.","resumen":"Ca(V)2.1 Ca(2+) channels have a dominant and specific role in initiating fast synaptic transmission at central excitatory synapses, through a close association between release sites and calcium sensors. Familial hemiplegic migraine type 1 (FHM-1) is an autosomal-dominant subtype of migraine with aura, caused by missense mutations in the CACNA1A gene that encodes the &#945;(1A) pore-forming subunit of Ca(V)2.1 channel. We used knock-in (KI) transgenic mice harboring the FHM-1 mutation R192Q to study the consequences of this mutation in neurotransmission at the giant synapse of the auditory system formed by the presynaptic calyx of Held terminal and the postsynaptic neurons of the medial nucleus of the trapezoid body (MNTB). Although synaptic transmission seems unaffected by low-frequency stimulation in physiological Ca(2+) concentration, we observed that with low Ca(2+) concentrations (<1 mM) excitatory postsynaptic currents (EPSCs) showed increased amplitudes in R192Q KI mice compared with wild type (WT), meaning significant differences in the nonlinear calcium dependence of nerve-evoked transmitter release. In addition, when EPSCs were evoked by broadened presynaptic action potentials (achieved by inhibition of K(+) channels) via Ca(v)2.1-triggered exocytosis, R192Q KI mice exhibited further enhancement of EPSC amplitude and charge compared with WT mice. Repetitive stimulation of afferent axons to the MNTB at different frequencies caused short-term depression of EPSCs that recovered significantly faster in R192Q KI mice than in WT mice. Faster recovery in R192Q KI mice was prevented by the calcium chelator EGTA-AM, pointing to enlarged residual calcium as a key factor in accelerating the replenishment of synaptic vesicles.","palabras_clave":"MIGRAINE|CALCIUM CHANNELS|CALYX OF HELD|ELECTROPHYSIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3397,"idioma_id":4,"titulo":"SEWAGE-INDUCED POLYCHAETE REEFS IN A SW ATLANTIC SHORE: RAPID RESPONSE TO SMALL SCALE DISTURBANCE","resumen":"The intertidal zone around Mar del Plata\u2019s sewage discharge (38 S, 57 W) is  characterized by the presence of the non-indigenous spionid polychaete Boccardia  proboscidea. This species has been classified as tolerant to moderate and  high levels of organic contamination. During early stages of colonization this  species can reach very high densities without suffering from interspecific competition,  building biogenic structures such as reef. The aim of this work was  evaluate the recovery time of the reef to a small-scale experimental physical disturbance.  Five independent rocks with B. proboscidea reefs on them were  selected randomly and a small-scale disturbance was generated by corers  (16 cm2). At the beginning of the experiment, six corers were collected in each  reef to produce the disturbance. The original density of B. proboscidea in each  reef was determined in these corers. The reefs with disturbed corer were sampled  on successive days to assess the reef recovery time. The number of larvae,  juveniles and adults was quantified. Polychaete reefs had very high densities  before the disturbance (mean density: 1,021,250 ind m)2). Boccardia proboscidea  reefs had a fast recovery rate after small-scale disturbance. Four days after  disturbance the density reached about 50% of the original density and after  5 days the disturbed reefs could not be differentiated from the undisturbed  reef. The initial recolonization of disturbed patches occurs as a result of migration  which appears to be driven by larvae and juveniles. These reefs can not be  seen as biodiversity hotspots and the presence of the species demonstrates great  environmental deterioration.","palabras_clave":"INTERTIDAL|POLYCHAETA REEFS|SEWAGE IMPACTED AREA|SPIONIDAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3398,"idioma_id":4,"titulo":"Reproductive behaviour and development dinamycs of Odontophrynus cordobae Martino and Sinsch, 2002 (Anura, Cycloramphidae)","resumen":"We provide detailed information on breeding sites, release call, satellite behaviour, courtship, and embryonic and larval development of Odontophrynus cordobae. Field observations were carried out during two breeding seasons (2004\u20132005 and 2008\u20132009). Clutches were raised in captivity (artificial ponds) to analyse the development of embryos and tadpoles. Breeding sites were represented by streams and their backwaters, as well as temporary and permanent ponds of varying sizes. Operational sex ratio was male-biased varying between 0.154 and 0.25. Acoustic activity started about 8\u201310 pm and ended between 2 and 4 amthe next day. Distance among calling males was approximately three metres. Male satellite behaviour was observed. Amplexus attempts among males were common. Release calls were structurally similar although shorter than advertisement calls. Courtship and formation of amplexus were documented","palabras_clave":"Odontophrynus; breeding behaviour; courtship"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3399,"idioma_id":4,"titulo":"Probiotics: An alternative strategy for combating salmonellosis. Immune mechanisms involved","resumen":"Salmonella produces infections of different nature and severity depending of many factors including the Salmonella serovar involved, strain virulence, infective dose, host animal species, age and immune status of the host. The treatments against Salmonella infections rely on supportive and antibiotic therapy to eliminate the pathogen, but the development of resistance by Salmonella to the antimicrobials most commonly used 22produces infections of different nature and severity depending of many factors including the Salmonella serovar involved, strain virulence, infective dose, host animal species, age and immune status of the host. The treatments against Salmonella infections rely on supportive and antibiotic therapy to eliminate the pathogen, but the development of resistance by Salmonella to the antimicrobials most commonly used 22 limits its efficacy. Other disadvantages of antibiotic treatments are that they can lead to acute diarrhea (antimicrobials normally induce an imbalance of intestinal bacterial flora) and may produce chronic toxicity. Considering this undesired consequences of antibiotics and because at the present there are no effective oral vaccines which protect against salmonellosis, scientists have been searching for alternative methods to control enteric infections. In the present review, probiotics are proposed as an attractive possibility to attend this concern. Probiotic are live microorganisms, which when administered in adequate amounts confer a health benefit on the host. In vitro and in vivo studies showed the effectiveness of probiotic administration in the prevention or in the treatment against Salmonella infection. There are several mechanisms by which probiotic strains might exert their effects. They include non immune mechanism (stabilization of the gut mucosal barrier, competition for adhesion, secretion of antimicrobial substances, etc.) and the modulation of the mucosal and systemic immune responses. These mechanisms are species and\/or strain specific. There are also evidences that in some cases, a mix of probiotic strains can be more useful than each strain alone against this infection. In addition, the presence of one or more probiotic strains in a fermented product can improve the beneficial properties of the probiotic strains involved. It was also reviewed the security of probiotics administration after Salmonella infection in healthy host and in immunosuppressed or babies hosts. Although, themajor part of the researches were performed in animalmodels through in vivo assays or by in vitro studies using human cell lines, some studies carried out in humans to verify the probiotic effects were also addressed in the present review. Nevertheless, is of critical importance to perform more clinical trials in humans to validate the results obtained with each specific probiotic strain or probiotic product.ficacy. Other disadvantages of antibiotic treatments are that they can lead to acute diarrhea (antimicrobials normally induce an imbalance of intestinal bacterial flora) and may produce chronic toxicity. Considering this undesired consequences of antibiotics and because at the present there are no effective oral vaccines which protect against salmonellosis, scientists have been searching for alternative methods to control enteric infections. In the present review, probiotics are proposed as an attractive possibility to attend this concern. Probiotic are live microorganisms, which when administered in adequate amounts confer a health benefit on the host. In vitro and in vivo studies showed the effectiveness of probiotic administration in the prevention or in the treatment against Salmonella infection. There are several mechanisms by which probiotic strains might exert their effects. They include non immune mechanism (stabilization of the gut mucosal barrier, competition for adhesion, secretion of antimicrobial substances, etc.) and the modulation of the mucosal and systemic immune responses. These mechanisms are species and\/or strain specific. There are also evidences that in some cases, a mix of probiotic strains can be more useful than each strain alone against this infection. In addition, the presence of one or more probiotic strains in a fermented product can improve the beneficial properties of the probiotic strains involved. It was also reviewed the security of probiotics administration after Salmonella infection in healthy host and in immunosuppressed or babies hosts. Although, themajor part of the researches were performed in animalmodels through in vivo assays or by in vitro studies using human cell lines, some studies carried out in humans to verify the probiotic effects were also addressed in the present review. Nevertheless, is of critical importance to perform more clinical trials in humans to validate the results obtained with each specific probiotic strain or probiotic product.","palabras_clave":"PROBIOTIC|IMMUNE SYSTEM|SALMONELLOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3400,"idioma_id":4,"titulo":"Electrochemical Reduction of the Mycotoxin Citrinin at Bare and Modified with Multi-Walled Carbon Nanotubes Glassy Carbon Electrodes in a Non-Aqueous Reaction Medium","resumen":"Electrochemical reduction mechanism of citrinin in acetonitrile plus 0.1 mol L-1 (C4H9)4NClO4 at both bare and modified with multi-walled carbon nanotube glassy carbon (GC) electrodes was investigated by cyclic voltammetry and controlled potential electrolysis. Results allowed to infer a complex electroreduction mechanism with chemical and electrochemical steps coupled to the initial electron transfer reaction. Citrinin shows a single cathodic peak that corresponds at least totwo electron reduction steps and two homogeneous chemical reactions, conforming to an ECEC (electron-transfer coupled with proton acceptance) self-protonation mechanism. The chemical reactions are originated in the intermolecular proton transfers from the substrate to its basicreduction intermediates, featuring a self-protonation mechanism. Kinetics analysis by simulation procedures of voltammetric results permitted a fully characterization of the mechanism of citrinin heterogeneous reduction.","palabras_clave":"CITRININ|MYCOTOXINS|MULTI-WALLED CARBON NANOTUBES|CYCLIC VOLTAMMETRY|SQUARE WAVE VOLTAMMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3401,"idioma_id":4,"titulo":"Working on the Threshold of the Human Error in Maintenance Tasks (Indexed by Thomson Reuters)","resumen":"      Abstract? In  this paper a new way to face the threshold of Human Error is presented. It  explains the mean of threshold from the neuroscience discipline and how it must  be applied in maintenance tasks for Nuclear Power Plants. This paper proposes  incorporate tools of augmented reality and present a framework that defines the  rules and bounds for its implementation in maintenance tasks. An overview of  Human Error is presented to introduce the main issues in the right context.  Finally a discussion on the proposed application is carried out on a number of  maintenance tasks in nuclear facilities.  ","palabras_clave":"Human|Error|Maintenance|Reliability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3402,"idioma_id":5,"titulo":"RELACION ENTRE LA HETEROGENEIDAD AMBIENTAL Y EL PATRÓN DE DISTRIBUCION Y LA RIQUEZA DE AVES EN DOS UNIDADES DE PAISAJES DEL DELTA DEL PARANA, ARGENTINA","resumen":"Los factores implicados en determinar la diversidad y la abundancia en las comunidades de aves son variados. Entre ellos, la estructura del hábitat, referida tanto a la fisonomía de la vegetación como a su variación espacial, ha sido reconocida como un factor de gran importancia en la determinación de la distribución y diversidad de aves por influir tanto en la selección de hábitat como en la disponibilidad de recursos críticos. En este contexto, el objetivo general de este estudio fue analizar la influencia de la heterogeneidad ambiental como condicionante de la diversidad de aves en dos unidades de paisaje de la región del Delta del Río Paraná. Se realizaron censos de aves a partir de los cuales se calcularon parámetros comunitarios. Se estimaron, además, variables relacionadas con la estructura de la vegetación. Se correlacionaron distintas medidas de heterogeneidad de la vegetación con la riqueza  de especies de aves. Los resultados obtenidos muestran un patrón diferencial del ensamble de aves de cada unidad y esto se corresponde con lo observado en la vegetación a nivel fisonómico y de composición de especies. Las variables ambientales permitieron diferenciar los ensambles presentes en los distintos ambientes de cada unidad de paisaje.","palabras_clave":"WETLANDS|PARANA RIVER DELTA|ENVIRONMENTAL HETEROGENEITY|BIRD COMMUNITIES|LANDSCAPE STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3403,"idioma_id":4,"titulo":"Synergistic effect of surfactin from Bacillus subtilis C4 and Achyrocline satureioides extracts on viability of Paenibacillus larvae","resumen":"The aim of this work was to determine the in vitro effect of the mixture between the lipopeptide surfactin, synthesized by Bacillus subtilis C4 (strain isolated from honey) and the most active vegetal extract from Achyrocline satureioides, a traditional medicinal plant, on local strains of Paenibacillus larvae, the agent of American Foulbrood in honeybees. Five P. larvae strains isolated in Cordoba, Argentina, were  phenotypically characterized. These and 12 other P. larvae strains from different regions of Argentina were analysed. The antimicrobial  activities of the essential oil, hexane (HE) and benzene extracts from  A. satureioides were assessed against P. larvae and the HE showed the highest anti-P. larvae activity. A combination of the biosurfactant surfactin, produced by B. subtilis C4, and the HE of A. satureioides revealed a synergistic action on P. larvae. The effective surfactin concentration in the mixture decreased from 32 to 1 ug ml-1 and the HE concentration from 32 to 4 ug ml-1, values similar or equal to  minimal inhibitory concentrations observed for oxytetracycline.  The fractional inhibitory concentration index confirmed synergism in 4 strains and partial synergism in one strain. The combination of surfactin synthesized by B. subtilis C4 and the HE from A. satureioides could be a  natural alternative to help beekeepers to combat the American foulbrood agent P. larvae.","palabras_clave":"Surfactin|Achyrocline satureioides|Paenibacillus larvae|synergism|antimicrobial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3404,"idioma_id":5,"titulo":"Disponibilidad de recursos líticos y explotación humana del límite de Los Andes, valle del río de Las Taguas, San Juan, Argentina","resumen":"A través del análisis de disponibilidad y explotación de recursos líticos, se exploran características de la ocupación del límite argentino-chileno. El área se localiza en el NO de San Juan (Argentina) y comprende desde el límite de vertientes cordilleranas (4.500 msm) hasta los valles próximos (3.700 msm). Se definen patrones espaciales para el uso de estos ambientes considerando: variaciones altitudinales, caracterización de fuentes de materias primas líticas y actividades de talla asociadas. Los sectores más altos, con fuentes primarias, muestran estadios iniciales de la secuencia reductiva y menor densidad de elementos líticos. Los sectores más bajos muestran altas densidades y secuencias completas asociadas a fuentes secundarias. Se elaboran propuestas preliminares sobre los patrones temporales de ocupación considerando la composición del registro lítico en un sitio con una secuencia de ca.9.000 años y los datos paleoambientales disponibles. Según esta aproximación, el área habría sido explorada luego de la última retirada de los hielos. Las ocupaciones humanas sucesivas coinciden temporalmente con períodos de disponibilidad hídrica en cordillera y aridez en altitudes menores de la vertiente occidental. Teniendo en cuenta las características topográficas, el registro arqueológico y los datos paleoambientales, se propone que el área habría sido explotada desde esa vertiente.","palabras_clave":"DISPONIBILIDAD|RECURSOS|LÍTICOS|CORDILLERA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3405,"idioma_id":5,"titulo":"Distribución de frecuencias de los deseos en las palabras de los pacientes y terapeutas  en psicoterapia. Un estudio con el diccionario computarizado del algoritmo David Liberman","resumen":"-------","palabras_clave":"distribución de frecuencias|diccionario computarizado|ADL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3406,"idioma_id":4,"titulo":"Indian hedgehog signalling is required for proper formation, maintenance and migration of Xenopus neural crest. (http:\/\/dx.doi.org\/10.1016\/j.ydbio.2012.01.020)","resumen":"&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The neural crest induction is the result of combined action at the neural plate border of FGF, BMP, and Wnt signals from the neural plate, mesoderm and nonneural ectoderm. In this work we show that the expression of Banded hedgehog and members of the Hedgehog pathway occurs at the prospective neural fold, in the premigratory and migratory neural crest. We performed a functional analysis that revealed the requirement of Bhh signaling in the neural crest development. During the early steps of neural crest induction loss of function experiments with antisense morpholino or locally grafted cyclopamine- loaded beads suppress the expression of early neural crest markers concomitant with the increase in neural and epidermal markers. We show that changes in Bhh activity produce no alterations neither in cell proliferation nor apoptosis suggesting that this signal involves cell fate decisions. A temporal analysis shows that hedgehog is continuously required not only in the early and late specification but also during the migration of the neural crest. We also established that the mesodermal source of Bhh is important in the maintenance of specification and to support the migratory process. By a combination of embryological and molecular approaches our results demonstrate that Bhh signaling drives in the migration of neural crest cells by autocrine or paracrine mechanisms. Finally, the abrogation of Bhh signaling strongly affected only the formation of cartilages derived from the neural crest, while no effects were observed in melanocytes. Taken together, our results provide insights on the role of Bhh cell signaling pathway during early steps of neural crest development.                                         ","palabras_clave":"CELL SIGNALING|HEDGEHOG|CELL SPECIFICATION|EMBRYOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3438,"idioma_id":4,"titulo":"A revision and phylogenetic analysis of the spider genus Aysenia Tullgren (Araneae: Anyphaenidae, Amaurobioidinae)","resumen":"The genus Aysenia Tullgren includes species of spiders endemic of the southern forests in Chile and Argentina. They have an elongated body, recurved posterior eye row and third legs directed forward. There are currently five known species of Aysenia. The study of all the specimens of Aysenia available in collections showed the existence of three undescribed species, and the unknown male of A. elongata, which are here described. New geographical records are provided for all species, with illustrations, and the reviewed diagnosis of the genus and of the previously known species. The data from the new species and the male of A. elongata are used to test the monophyly of the genus, its relationships with other genera in the family, and among its species. The phylogenetic analysis using cladistic methods uses observations from 264 previously defined characters plus three characters that arise from this study, scored for 104 species of Anyphaenidae.","palabras_clave":"CLADISTICS|NEW SPECIES|SOUTH AMERICA|SYSTEMATICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3464,"idioma_id":4,"titulo":"Multi-channel search for squarks and gluinos in &#8730;s=7 TeV pp collisions with the ATLAS detector","resumen":"A search for supersymmetric particles in final states with zero, one, and two leptons, with and without jets identified as originating from b-quarks, in 4.7 fb&#8722;1 of s&#8730;=7 TeV pp collisions produced by the Large Hadron Collider and recorded by the ATLAS detector is presented. The search uses a set of variables carrying information on the event kinematics transverse and parallel to the beam line that are sensitive to several topologies expected in supersymmetry. Mutually exclusive final states are defined, allowing a combination of all channels to increase the search sensitivity. No deviation from the Standard Model expectation is observed. Upper limits at 95 % confidence level on visible cross-sections for the production of new particles are extracted. Results are interpreted in the context of the constrained minimal supersymmetric extension to the Standard Model and in supersymmetry-inspired models with diverse, high-multiplicity final states.","palabras_clave":"ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3472,"idioma_id":4,"titulo":"Crystal structure and magnetic properties of two new zoledronate complexes: 3 A Mn dimer [Mn(II)(H3Zol)2\u0002(H2O)2] and a Fe15 molecular cluster 4 [Fe(III)15(HZol)10(H2Zol)2 (H2O)12(Cl4:(H2O)2)\u0002Cl7\u0002(H2O)65] (where H4Zol: C5H10N2- 5 O7P2 is zoledronic acid)","resumen":"The synthesis, X-ray structure and magnetic properties of two new zoledronato complexes are presented:Mn(II)(H3Zol)2(H2O)2, (I) and Fe(III)15(HZol)10(H2Zol)2 (H2O)24 (2\/3Cl:1\/3H2O)67Cl65(H2O) (II), where H4Zol = zoledronic acid = C5H10N2O7P2. Complex (I) is a dimer, built up around an inversion centre where the cation is located, surrounded by two chelating zoledronate anions and two water molecules. The structure is isomorphous to the Co, Ni and Zn isologues. A quite different structure is the Fe(III) complexwhich consists of a centrosymmetric cluster with 15 Fe(III) cations (one of them at the inversion centre), 12 zoledronate anions, in different protonation states and 26 coordinated water molecules, 24 of which show full occupancy and the remaining 2 share 6 coordination sites with 4 chlorine anions. There are in addition 7 chlorine counterions and a not well determined number of hydration water molecules, their number being adjusted as to match the chemical and TGA analysis. The general shape of the molecule is that of a 6 arm propeller with a Fe(III) cation at its center and two FeO6 coordination polyhedra sitting above and below, defining some sort of \u2018\u2018paddle wheel axis\u2019\u2019, perpendicular to the wheel plane. Around this axis there is an almost perfect circular structure formed by other six FeO6 octahedra, to which the \u2018\u2018paddles\u2019\u2019, defined by the remaining six FeO6 groups attach. The ensemble presents some unusual(FeOPO)n loops (n = 2,3,4), some of them unreported, and displays a striking non-crystallographic 3 symmetry. The protonation state of the zoledronato ligands were inferred from the counterions effectivelyfound and charge balance considerations. Both compounds present a paramagnetic behaviour at R.T, and obey a Curie Weiss law down to rather low temperatures (15 K for (I), 100(K) for (II)) with a tendency to different types of interactions viz., ferromagnetic for (I) and antiferromagnetic for (II). The geometry of the F15 cluster is analyzed.","palabras_clave":"Cluster de Fe|Difraccion de Rayos X|Propiedades magneticas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3473,"idioma_id":5,"titulo":"Modelización de la Tasa de interés como Reseña de Herramientas de la  Econometría  Financiera","resumen":"El trabajo versa sobre las alternativas y herramientas que la econometría   financiera brinda para la modelización de la tasa de interés, resaltando las   bondades y dificultades de cada alternativa, además de la evidencia empírica   involucrada en cada estimación.   Los modelos de tasas de interés han tenido una vasta aplicación en la práctica   financiera. Algunas herramientas son usadas para: política monetaria, finanzas   corporativas, riesgo crediticio, derivados financieros, entre otros.   Los modelos de econometría financiera para precios de acciones y tipos de   cambios son modelos de precios (Modelos ARIMA), y de volatilidad (Modelos   GARCH).","palabras_clave":"TASA DE INTERES|ECONOMETRIA FINANCIERA|MODELOS AUTOREGRESIVOS|CURVA DE RENDIMIENTOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3474,"idioma_id":5,"titulo":"Prólogo - I Jornadas Internacionais Descobrindo Culturas em Língua Portuguesa","resumen":"Prólogo de las I Jornadas Descobrindo Culturas em Língua Portuguesa","palabras_clave":"interculturalidad|lengua portuguesa|cultura|jornadas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3476,"idioma_id":4,"titulo":"AcMNPV core gene ac109 is required for budded virion transport to the nucleus and for occlusion of viral progeny","resumen":"Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 core gene has been previously characterized as an essential late gene. Our results showed that even when ac109 knockout viruses display a single-cell infection phenotype, budded virions can be detected in supernatants of infected Sf-9 cells. Confocal microscopy analysis showed that budded virions can enter the cytoplasm but are unable to enter the cell nucleus. This defect could be repaired by complementing ac109 in trans. In addition, polyhedra of normal size can be detected in Sf-9 nuclei infected with ac109 knockout viruses. However, electron microscopy demonstrated that these occlusion bodies are empty. Altogether these results indicate that ac109 is required for infectivity of both phenotypes of virus.","palabras_clave":"BACULOVIRUS|AcMNPV|ac109|KNOCKOUT BACMID|ODV MORPHOGENESIS|BV INFECTIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3477,"idioma_id":4,"titulo":"A combined approach of VNTR and MLST analysis: Improvement of molecular typing of argentinean isolates of Leptospira interrogans.","resumen":"Leptospirosis is a global emerging infectious disease that has been identified as a public and animal health problem. Regular outbreaks associated with specific risk factors have been reported in Argentina. However, no data on a genetic population level is available for this pathogen in Argentina. Therefore, this work aims to describe the genetic diversity Leptospira interrogans through the application of two molecular typing strategies, VNTRs and MLST.For this purpose, 7 reference strains and 18 non-epidemiologically related isolates from diverse hosts and Argentinean regions were analyzed. Among them, 9 genotypes and 6 STs, including 3 unreported STs, were described by VNTRs and MLST, respectively. eBURST analysis showed ST37 as the most frequent and founder genotype of a clonal complex with STN1 and STN3 suggesting the importance of studying the serovars belonging to this clonal complex in Argentina. Maximum Parsimony analysis merging both techniques data achieved intraserovar discrimination, overcame MAT discrepancies and increased the discriminatory power of each technique applied separately. This work represents the first report which combines both strategies for L. interrogans typing and allowed to deepen the molecular genotyping of isolates from Argentina in a global context.","palabras_clave":"MULTILOCUS SEQUENCE TYPING|VARIABLE NUMBER TANDEM REPEATS|LEPTOSPIRA INTERROGANS|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3478,"idioma_id":5,"titulo":"Comparación de la eficiencia de extracción de ácidos nucleicos utilizando distintos equipos comerciales y empleando la qPCR. Efecto de las sustancias inhibidoras","resumen":"La detección de secuencias específicas de ácidos nucleicos (AN) empleando PCR revolucionó las ciencias biológicas y médicas. La PCR en tiempo real (qPCR) incorporó la posibilidad de obtener resultados cuantitativos. Una etapa decisiva previa a qPCR es la extracción de AN en la que se pueden producir tanto la remoción como la extracción conjunta de sustancias inhibidoras de la reacción enzimática, afectando a la eficiencia de amplificación. En el presente trabajo se realizó una comparación entre los kits de extracción comerciales Qiagen, Invitrogen y Macherey-Nagel, utilizados para extraer ADN de Trypanosoma cruzi de sangre murina artificialmente infectada y ARN de PP7, bacteriófago de Pseudomonas aeruginosa, sembrado en matrices acuosas. La eficiencia de recuperación de AN en muestras sin inhibidores fue similar para los tres kits de extracción. El kit de Invitrogen fue el único que no se vio afectado por la presencia de inhibidores en las muestras.","palabras_clave":"ACIDOS NUCLEICOS|EXTRACCION|PCR EN TIEMPO REAL|INHIBICION|EFICIENCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3479,"idioma_id":4,"titulo":"Membrane-active bacteriocins to control Salmonella in foods Are they the definite hurdle?","resumen":"According to recent surveys salmonellosis is the main disease caused by   foodborne microorganisms in many countries. Although traditional methods   to control bacterial contamination in food are effective in controlling   Salmonella, a major problem arises with fresh and organic food   demanded by the market with little preparation and no chemical   additives. Besides the development of new technologies that combine soft   physical and chemical treatments in a way that causes minimal changes   in food properties, antimicrobial peptides derived from natural sources   are presented as an interesting alternative to chemical preservatives.   There are many bacteriocins active against Salmonella and they   could be used in the food industry alone or in combination with other   hurdles to increase the antisalmonella effect in the so-called hurdle   technology. However, further studies are necessary to demonstrate the   safety of new bacteriocins and to improve their activity in different   environmental conditions encountered during food processing. Moreover,   nisin and pediocin PA-1 already approved as food preservatives by   various government agencies, can be used along with other hurdles to   control the pathogen in foods. In this paper the use of bacteriocins as   hurdles for controlling Salmonella in the future is discussed and analyzed.","palabras_clave":"MICROCINS|BACTERIOCINS|ANTIMICROBIAL PEPTIDES|FOOD PRESERVATION|BIOPRESERVATION|SALMONELLA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3480,"idioma_id":4,"titulo":"Climatological patterns over South America derived from COSMIC radio occultation data","resumen":"Meteorological phenomena are closely linked to the presence of water vapor. They are mainly originated and developed in the troposphere, where  almost all the atmospheric water is concentrated. The Global Positioning System Radio Occultation (GPS RO) technique provides vertical pro&#64257;les of refractivity from which other properties such as temperature and water vapor can be derived. The GPS RO capability to reproduce global, synoptic and regional climatological patterns over South America, which is a mostly oceanic continent, is tested. From FORMOSAT-3\/COSMIC mission data (2006-2010), our previous knowledge regarding global and synoptic\/regional patterns of temperature, equivalent potential temperature, speci&#64257;c humidity and pressure is veri&#64257;ed. Special cases such as baroclinic disturbances arriving at South America midlatitudes and storm events over a mountain region near the Andes are analyzed. The temporal evolution and the latitude-longitude distribution in several layers of the variables listed above are well described with  this technique.","palabras_clave":"RADIO OCULTAMIENTO SATELITAL|HUMEDAD ATMOSFERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3481,"idioma_id":5,"titulo":"Diversidad y análisis panbiogeográfico de las licofitas (Equisetopsida: Lycopodiidae) del Parque Nacional Calilegua, Jujuy, Argentina","resumen":"Las licofitas son las plantas vasculares más antiguas y constituyen el grupo hermano de las demás traqueofitas. Son especialmente adecuadas para establecer patrones biogeográficos, debido a su falta de relaciones coevolutivas con vectores bióticos, su monofilia y su patrón morfológico altamente estable. En esta contribución se da a conocer la flora de licofitas del Parque Nacional Calilegua y se establecen sus relaciones biogeográficas mediante un análisis panbiogeográfico. Se encontraron nueve especies representando dos familias: Lycopodiaceae y Selaginellaceae. Los géneros más diversos son Huperzia (cuatro especies) y Selaginella (tres especies). Se construyeron los trazos individuales de los taxones encontrados y el trazo generalizado resultante indica que la región del Parque Nacional Calilegua forma parte del componente biótico neotropical que finaliza en las Sierras centrales de Argentina. El trazo generalizado bordea la Zona de Transición Sudamericana, caracterizada por ambientes áridos, que constituye una barrera exitosa para las licofitas, separando las regiones Andina y Neotropical. Además esta región posee relaciones estrechas con la subregión Paranaense de la región Neotropical, salvando la barrera árida representada por la subregión Chaqueña, patrón que se encuentra sustentado por otros taxones.","palabras_clave":"Yungas|Lycopodiaceae|Sellaginelaceae|Biogeografía|Diversidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3482,"idioma_id":4,"titulo":"Shiga toxin-producing Escherichia coli O157 : H7 shows an increased pathogenicity in mice after the passage through the gastrointestinal tract of the same host","resumen":"Hemolytic Uremic Syndrome (HUS) is a rare but life-threatening complication of Shiga toxin (Stx)-producing Escherichia coli (STEC) infections, characterized by acute renal failure, thrombocytopenia and hemolytic anemia. Although the main infection route is the consumption of contaminated food or water, person-to-person transmission has been suggested in several situations. Moreover, epidemiological data indicate that the horizontal transmission of several pathogens, including STEC, among individuals of the same species requires significantly lower doses than those used in animal models infected with laboratory-cultured bacteria. Thus, the aim of this study was to evaluate whether the passage of a clinical-isolated STEC strain through the gastrointestinal tract of mice affects the pathogenicity in mice. To test this, weaned mice were orally inoculated by gavage with either an E. coli O157:H7 isolated from an HUS patient, or the same strain recovered from stools after one or two successive passages through the gastrointestinal tract of mice. We show that stool-recovered strains are able to induce a more generalized and persistent colonization than the parent strain. Furthermore, a 104-fold-reduced inoculum of the stool-recovered strains still causes gut colonization and mouse mortality, which are not observed with the parent strain. These results indicate an increased pathogenicity in stool-recovered strains that may be associated with an increased ability to colonize the mouse intestine. ","palabras_clave":"Stool-recovered strain|increased pathogenicity|Stx2|HUS mouse model"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3484,"idioma_id":4,"titulo":"Photosensitized electron transfer within a self-assembled norharmane\u2013 2&#8242;-deoxyadenosine 5&#8242;-monophosphate (dAMP) complex","resumen":"Norharmane is a compound that belongs to a family of alkaloids called ¦Â-carbolines (¦ÂCs). These alkaloids are present in a wide range of biological systems, playing a variety of significant photodependent roles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byroles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byalkaloids are present in a wide range of biological systems, playing a variety of significant photodependent roles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byroles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byharmane is a compound that belongs to a family of alkaloids called ¦Â-carbolines (¦ÂCs). These alkaloids are present in a wide range of biological systems, playing a variety of significant photodependent roles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byroles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) byficant photodependent roles. Upon UV-A irradiation, ¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) bywe have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) by¦ÂCs are able to act as efficient photosensitizers. In this work, we have investigated the photosensitized oxidation of 2¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) by¡ä-deoxyadenosine 5¡ä-monophosphate (dAMP) by norharmane in an aqueous phase, upon UV-A (350 nm) irradiation. The effect of the pH was evaluated on both the interactions between norharmane and dAMP in the ground and electronic excited states, and on the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationon the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationon both the interactions between norharmane and dAMP in the ground and electronic excited states, and on the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationon the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationharmane in an aqueous phase, upon UV-A (350 nm) irradiation. The effect of the pH was evaluated on both the interactions between norharmane and dAMP in the ground and electronic excited states, and on the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationon the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationnorharmane and dAMP in the ground and electronic excited states, and on the dAMP photosensitized oxidation. A quite strong static interaction between norharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationwas observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationnorharmane and dAMP was observed, especially under those pH conditions where the protonated form of the alkaloid is present(pH &lt; 7). Theoretical studies were performed to further characterize the static complex structure. Theparticipation of reactive oxygen species (ROS) in the photosensitized reaction was also investigated andthe photoproducts were characterized by means of UV-LDI-MS and ESI-MS. All the data provided hereinindicate that electron transfer (Type I) within a self-assembled norharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitizationoperative mechanism in the dAMP photosensitizationnorharmane¨CdAMP complex is the operative mechanism in the dAMP photosensitization","palabras_clave":"nor-harmano|Photosensitizer|Nucleotides|Photooxidation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3485,"idioma_id":5,"titulo":"PROPUESTA DE TERMINOLOGÍA PARA LOS REPORTES DE LABORATORIOS DE NUTRICIÓN ANIMAL","resumen":"La valoración nutricional de los alimentos constituye un eslabón fundamental para el correcto funcionamiento de la agroindustria asociada con la alimentación de animales. El creciente desarrollo de las técnicas analíticas y la mayor difusión de los controles de calidad sobre los ingredientes y alimentos terminados ha generalizado el uso de términos asociados con la calidad de los alimentos, muchas veces pobremente definidos. Los objetivos de este artículo fueron: resaltar algunos conceptos relevantes para determinar el valor de los alimentos para animales; contribuir a mejorar el uso e interpretación de los resultados analíticos; llamar la atención sobre algunos procedimientos y estimaciones que dan lugar a confusiones o malas interpretaciones. Asimismo se propuso un listado de siglas para identificar algunas de las fracciones analíticas frecuentemente usadas en la evaluación de alimentos para rumiantes.","palabras_clave":"EVALUACION DE ALIMENTOS|INCERTIDUMBRE|ERROR|FUENTES DE VARIACION|PROCEDIMIENTOS ANALITICOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3487,"idioma_id":5,"titulo":"Transmisión transplacentaria de Neospora caninum en bovinos de cría de la Provincia de Corrientes, Argentina","resumen":"La neosporosis es una de las principales enfermedades causantes de abortos en bovinos. Su agente etológico es Neospora caninum, protozoario Apicomplexa transmitido al ganado por vía transplacentaria y alimentos contaminados por deyecciones de distintas especies de cánidos, sus hospedadores definitivos. En el presente trabajo se evaluó la frecuencia de transmisión de N. caninum in útero y post partum en 56 vacas de raza Brahman y Brangus serológicamente positivas, así como en sus crías al nacimiento y prospectivamente hasta el año de edad, mediante las pruebas de enzimoinmunoensayo indirecto (ELISAi), cuyos resultados se expresaron en porcentaje de positividad (PP), e nmunofluorescencia indirecta. La proporción de animales positivos a neosporosis en las vacas y sus crías fue de 14,3% (8\/56) y 17,9% (10\/56) respectivamente. Cuarenta y seis vacas y sus terneros se clasificaron negativos la neosporosis (4,2 ± 3,8 PP, ELISAi). De los 10 terneros positivos, 8 eran hijos de madres positivas y de éstos sólo 5 fueron reactores positivos antes de ingerir calostro (51,6 ± 17,3 PP, ELISAi). Los 3 terneros restantes alcanzaron un valor similar (59,0 ± 38,1 PP, ELISAi). En el 62% de los terneros los niveles de anticuerpos se mantuvieron &#8805; 25 PP hasta los 6 meses de edad. Dos terneros nacidos con serología negativa seroconvirtieron a los nueve meses de edad.","palabras_clave":"BOVINO DE CARNE |NEOSPOROSIS|DIAGNOSTICO SEROLOGICO|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3488,"idioma_id":5,"titulo":"Resistencia osmótica eritrocitaria: Valor diagnóstico en el estudio de anemias hereditarias en Tucumán, Argentina","resumen":"Las anemias hereditarias más frecuentes en Tucumán (Argentina) son el rasgo beta talasémico (RBT), las hemoglobinopatías estructurales (HBP) y la esferocitosis hereditaria (EH). La resistencia osmótica eritrocitaria inmediata y 24 horas post-incubación constituye el método diagnóstico de la EH, y como tubo único (ROETU) es usada para cribado de RBT. El propósito del trabajo fue determinar el comportamiento de ROETU (4,0 y 5,5 g\/L de NaCl) en el diagnóstico de anemias hereditarias. Se estudiaron 125 pacientes: 34 normales (GN), 59 con RBT (GRBT), 21 con HBP (GHBP) y 11 con EH (GEH), que fueron agrupados en niños (&#8804;12 años), mujeres y hombres (>12 años). Se realizaron hemograma (Coulter AcT10 y Sysmex KX-21N), índices de Mentzer y de Shine&Lal, ROETU, hierro, transferrina y saturación de transferrina (Wiener Lab), reticulocitos (azul brillante de cresilo), prueba de falciformación y electroforesis de hemoglobina a pH alcalino y ácido. GRBT presentó anemia microcítica hipocrómica, y GEH y GHBP, anemia normocítica normocrómica. El hierro fue normal. GRBT y GHBP fueron resistentes en ROETU 4,0 g\/L, aunque GRBT mostró mayor resistencia (p<0,05). GEH fue menos resistente que GN en ROETU 5,5 g\/L (p<0,05). ROETU 4,0 y 5,5 g\/L serían recomendables en el diagnóstico presuntivo de RBT y EH, respectivamente.","palabras_clave":"RESISTENCIA OSMÓTICA ERITROCITARIA|TALASEMIAS|ESFEROCITOSIS|HEMOGLOBINOPATÍAS ESTRUCTURALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3557,"idioma_id":4,"titulo":"Mitochondrial As accumulation and speciation by SR-XRF-XANES at Laboratorio Nacional de Luz Sincrotron (LNLS).","resumen":"It is well established that chronic exposure to arsenic can cause cancerous and non-cancerous health hazards. However, epidemiological and experimental evidence suggest that the development of arsenic-related diseases is not only determined by the dosage of exposure, but also by its chemical form. Methylation of arsenite to monomethylarsonic acid (MMA) or dimethylarsinic acid (DMA) followed by other organoarsenic compounds, constitute the major biological reactions in the arsenic cycle. It is generally accepted that the +3 methylated arsenic species are more cyto- and genotoxic, and more potent enzyme inhibitors than both their pentavalent counterparts and the inorganic arsenic species. In this regard, becomes necessary to know chemical species of accumulated arsenic in target organs in order to do more efficient therapy strategies. In previous reports, mapping of As distribution obtained by SR-µXRF showed its accumulation in renal cortex from exposed rats (figure 1). In order to As speciation, arsenic K-edge XANES measurements in fluorescence mode and conventional incidence geometry (SR-XRF-XANES) were carried out using the set-up recently developed at the D09B-XRF beamline from the Brazilian Synchrotron Light Laboratory. By this procedure it was possible to determine As species in the renal mitochondrias. We conclude that SR-XRF-XANES is a new methodology available at LNLS for the successful determination of chemical species in different matrices.","palabras_clave":"ARSENICO|BIOACUMULACION|ESPECIACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3578,"idioma_id":5,"titulo":"INTRODUCCIÓN TOMO 2 biopolítica hoy.","resumen":"Se extiende el planteamiento inicial sobre los estudios en biopolitica en América Latina y el mundo. Se introduce una sucinta síntesis de los trabajos presentados y compilados en este tomo.","palabras_clave":"BIOPOLITICA|ESTUDIOS|ACTUALIDAD|TRANSFORMACIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3579,"idioma_id":4,"titulo":"AQUEOUS SOLVENT EFFECTS ON THE CONFORMATIONAL SPACE OF TRYPTAMINE. STRUCTURAL AND ELECTRONIC ANALYSIS","resumen":"The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Moreover, TRA, and other indolic compounds are very efficient antioxidants. In this work the conformational space of TRA was scanned in aqueous solution, simulating the solvent by the polarizable continuum model. Geometry optimizations were performed at B3LYP\/6-31+G** level. Electronic distributions were analyzed at a better calculation level, thus improving the basis set (6-311++G**). A topological study based on Bader?s theory (atoms in molecules) and natural bond orbital (NBO) framework was performed. Structural changes found in solution were related with charge delocalization mechanisms, which explained the changes in the conformational relative population in aqueous phase. Solvent effects on molecular electrostatic potential (MEPs) were also quantified and rationalized through charge delocalization mechanisms, thus connecting changes in MEPs with changes in structure, bond polarization, orbital bonding populations, natural charges, and bond topological properties. Moreover, polarizabilities and dipolar moments were calculated. All conformers were taken into account. Our results are the first prediction of TRA polarizabilities. The results reported contribute to the understanding of the structure, stability and reactivity of TRA and other indole derivatives.","palabras_clave":"(3-[2-aminoethyl]indole)|Aqueous solvent effect|Natural bond Orbital analysis|Atoms in Molecules"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3580,"idioma_id":4,"titulo":"Green catalytic synthesis of 14-aryl-14H-dibenzo a,j xanthenes using recyclable mesoporous zirconia modified with tungstophosphoric acid","resumen":"A simple and efficient procedure has been developed for the preparation of aryl-14H-dibenzo[a,j]xanthenes by a one-pot condensation of 2-naphthol and aryl aldehydes, in the presence of mesoporous zirconia modified with tungstophosphoric acid (ZrTPA60BT100), to be used as a heterogeneous catalyst in a solvent-free medium using conventional heating. The present approach offers the advantages of clean reaction, simple methodology, short reaction time, and high yield. The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused several times in subsequent reactions without appreciable loss of the catalytic activity.","palabras_clave":"Mesoporous zirconia|heteropolyacids|14-aryl-14H-dibenzo[a,j]xanthenes|solvent-free synthesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3581,"idioma_id":4,"titulo":"Role of Peroxisome Proliferator Activated Receptor-Gamma in Bacillus Calmette-Guérin Bladder Cancer Therapy","resumen":"Background: Peroxisome proliferator activated receptors (PPARs) are a superfamily of  nuclear receptors that are transcription factors activated by ligand. The activation of the  subtype gamma (PPARg) causes either inhibition or differentiation of tumor cells.  Previously, we have demonstrated that the inhibition of murine bladder tumor growth  induced by Bacillus Calmette-Guerin (BCG), the standard treatment for patients with  non-muscle invasive high-grade bladder cancer, increases PPARg expression in vitro  and in vivo. In vitro, cell growth inhibition induced by BCG is enhanced by the PPARg  agonist 15-d-PGJ2, raising the possibility that PPARg activation may be a therapeutic  modality in this disease. Objective: To evaluate the effects of combined PPARg agonist  with BCG in bladder cancer growth both in vitro and in vivo, focusing in tissue  remodeling mechanisms induced by BCG. Results: In MB49 cells, BCG and 15-d-  PGJ2 induced PPARg expression, nuclear translocation and transcriptional activity. In  vivo, BCG reduced tumor size, an effect that was partially reversed when BCG was  combined with the PPARg agonist Roziglitazone (RO). The same result was found  when we analyzed the effect of the PPARg antagonist BADGE in combination with  BCG. The analysis of the activation of macrophages and fibroblasts demonstrated that  RO inhibited tissue remodeling mechanisms induced by BCG. Conclusions: Our results  suggest that PPARg is involved in the anti-tumor action of BCG. However, we can  conclude that the use of exogenous PPARg agonists would not be a favorable  therapeutic modality because they can inhibit the tissue remodeling needed for an  overall satisfactory BCG response.","palabras_clave":"URINARY BLADDER NEOPLASMS|PPAR GAMMA|BCG VACCINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3582,"idioma_id":5,"titulo":"Caracterización y procedencia de obsidianas de sitios arqueológicos del Centro Oeste de Argentina y Centro de Chile con metodología no destructiva por fluorescencia de Rayos X (XRF)","resumen":"NON-DESTRUCTIVE X-RAY FLUORESCENCE (XRF) CHARACTERIZATION AND SOURCING OF OBSIDIAN FROM ARCHAEOLOGICAL SITES IN CENTRAL WEST ARGENTINA AND CENTRAL CHILE. The results of chemical analysis by X-ray Fluorescence (XRF) performed on 101 obsidian artifacts from archaeological sites of Central western Argentina and Central Chile are presented. A chemical characterization of six obsidian sources and subsources located in both Andean and extra-Andean environments of Southern Mendoza, Northern Neuquén and Central Chile, is also performed. Based on this information, different proposals related to mobility patterns and exchange systems of human societies that occupied the two slopes of the Andes during the middle and late Holocene are discussed. The results confirm that non-destructive X-ray Fluorescence is a valid tool to determine the origin and dispersal of archaeological obsidian artifacts.","palabras_clave":"X-ray Fluorescence|Obsidian|Archaeological artifacts provenance|Central western Argentina|Central Chile"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3584,"idioma_id":4,"titulo":"Synapsis, recombination and chromatin remodeling in the XY body of armadillos","resumen":"Abstract Three xenarthrans species Chaetophractus villosus, Chaetophractus vellerosus, and Zaedyus pichiy have been used for the analysis of the structure, behavior, and immunochemical features of the XY body during pachytene. In all these species, the sex chromosomes form an XY body easily identifiable in thin sections by the special and regular packing of the chromatin fibers of the internal region of the XY body (differential regions) and those of the peripheral region (synaptic region). Spermatocyte spreads show a complete synapsis between the X- and the Y-axis, which lasts up to the end of pachytene. From the early pachytene substages to the late ones, the X-axis develops prominent branches, which in late pachytene span the synaptic region. Synapsis is regular as shown by SYCP1 labeling. Axial development is followed by SYCP3 labeling and in the asynaptic region of the X axis by BRCA1. Gamma-H2AX labels exclusively the differential (asynaptic) region of the X chromosome. A single focus is labeled by MLH1 in the synaptic region. The location of this MLH1 focus spans from 0.3 to 1.6  from the telomere in the analyzed xenarthrans, covering approximately half of the Y-axis length. It is concluded that xenarthrans, as basal placental mammals, harbor the largest pseudoautosomal regions of presently analyzed mammals, and shows the typical features of meiotic sex chromosome inactivation (MSCI).","palabras_clave":"XY body|Pseudoautosomal region|MSCI|armadillos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3585,"idioma_id":4,"titulo":"Biology and Biotechnology of Early Follicle Development: a Review","resumen":"Growth and development of ovarian follicles require a series of coordinated events that induce morphological and functional changes within the follicle, leading to cell differentiation and oocyte development. The preantral early antral follicle transition is the stage of follicular development during which gonadotropin dependence is obtained and the progression into growing or atresia of the follicle is made. Follicular growth during this period is tightly regulated by oocyte-granulosatheca cell interactions. A cluster of early expressed genes is required for normal folliculogenesis. Granulosa cell factors stimulate the recruitment of theca cells from cortical stromal cells. Thecal factors promote granulosa cell proliferation and suppress granulosa cell apoptosis. Cell-cell and cell-extracellular matrix interactions influence the production of growth factors in the different follicular compartments (oocyte, granulosa, and theca cells). Several autocrine and paracrine factors are involved in follicular growth and differentiation; their activity is present even at the time of ovulation, decreasing the gap junction communication, and stimulating the theca cell proliferation. In addition, the identification of the factors that promote follicular growth from the preantral stage to the small antral stage may provide important information for the identification for assisted reproduction techniques.","palabras_clave":"ovary|bovine|MIV"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3586,"idioma_id":4,"titulo":"Toll-like Receptor-2 and Interleukine-6 Mediate Cardiomyocyte Protection from apoptosis during Trypanosoma cruzi murine infection","resumen":"Local innate immunity plays a key role in initiating and coordinating homeostatic and defense responses in the heart. We have previously reported that the cardiotropic parasite Trypanosoma cruzi, the etiological agent of Chagas disease, protects cardiomyocytes against growth factor deprivation-induced apoptosis. In this study, we investigated cardiomyocyte innate immune response to T. cruzi infection and its role in cellular protection from apoptosis. We found that Toll-like receptor (TLR) 2-expressing cellswere strongly increased by the parasite in BALB\/c neonatal mouse cardiomyocyte cultures. Using a dominant-negative system, we showed that TLR2 mediated cardiomyocyte survival and the secretion of interleukin (IL) 6,which acted as an essential antiapoptotic factor. Moreover, IL6 released by infected cells, as well as the recombinant bioactive cytokine, induced the phosphorylation of the signal transducers and activators of transcription-3 (STAT3) in cultured cardiomyocytes. In accord with the in vitro results, during the acute phase of the infection, TLR2 expression increased 2.9-fold and the antiapoptotic factor Bcl-2 increased 4.5-fold in the cardiac tissue. We have clearly shown a cross-talk between the intrinsic innate response of cardiomyocytes and the pro-survival effect evoked by the parasite.","palabras_clave":"INNATE IMMUNITY|TOLL-LIKE RECEPTOR-2 |SURVIVAL|CARDIOMYOCYTE|BCL-2|INTERLEUKINE-6|PARASITE INFECTION|STAT-3|ACUTE INFECTION|HEART TISSUE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3587,"idioma_id":4,"titulo":"Numerical Simulations of Ge Solar Cells using the D-AMPS-1D Code","resumen":"A solar cell is a solid state device that converts the energy of sunlight directly into electricity by the photovoltaic effect. When light with photon energies greater than the band gap is absorbed by a semiconductor material, free electrons and free holes are generated by optical excitation in the material. The main characteristic of a photovoltaic device is the presence of internal electric field able to separate the free electrons and holes so they can pass out of the material to the external circuit before they recombine. Numerical simulation of photovoltaic devices plays a crucial role in their design, performance prediction, and comprehension of the fundamental phenomena ruling their operation. The electrical transport and the optical behavior of the solar cells discussed in this work were studied with the simulation code D-AMPS-1D. This software is an updated version of the one-dimensional (1D) simulation program Analysis of Microelectronic and Photonic Devices (AMPS) that was initially developed at The Penn State University, USA. Structures such as homojunctions, heterojunctions, multijunctions, etc., resulting from stacking layers of different materials can be studied by appro- priately selecting characteristic parameters. In this work, examples of cells simulation made with D-AMPS-1D are shown. Particularly, results of Ge photovoltaic devices are presented. The role of the InGaP buffer on the device was studied. Moreover, a comparison of the simulated electrical parameters with experimental results was performed.","palabras_clave":"SOLAR CELLS|GERMANIUM|NUMERICAL SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3588,"idioma_id":4,"titulo":"Comparative phytohormone profiles, lipid kinase and lipid phosphatase activities in barley aleurone, coleoptile, and root tissues","resumen":"We analyzed lipid kinase and lipid phosphatase activities and determined endogenous phytohormone levels by liquid chromatographyetandem mass spectrometry in root and coleoptile tissues following germination of barley (Hordeum vulgare) seeds. The enzymes showing highest activity in aleurone cells were diacylglycerol kinase (DAG-k, EC 2.7.1.107) and phosphatidate kinase (PA-k). The ratio of gibber- ellins (GAs) to abscisic acid (ABA) was 2-fold higher in aleurone than in coleoptile or root tissues. In coleoptiles, phosphatidylinositol 4-kinase (PI4-k, EC 2.7.1.67) showed the highest enzyme activity, and jasmonic acid (JA) level was higher than in aleurone. In roots, activities of PI4-k, DAG-k, and PA-k were similar, and salicylic acid (SA) showed the highest concentration. In the assays to evaluate the hydrolysis of DGPP (diacylglycerol pyrophosphate) and PA (phosphatidic acid) we observed that PA hydrolysis by LPPs (lipid phosphate phosphatases) was not modi&#9251;ed; however, the diacylglycerol pyrophosphate phosphatase (DGPPase) was strikingly higher in coleoptile and root tissues than to aleurone. Relevance of these &#9251;ndings in terms of signaling responses and seedling growth is discussed.","palabras_clave":"Barley  |Lipid kinases|Lipid phosphate phoshatases |Phospholipids"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3590,"idioma_id":5,"titulo":"¿Riesgo de trastornos alimentarios en adolescentes de contexto rural?. Un estudio sobre la insatisfacción corporal y los déficits en habilidades sociales.","resumen":"La insatisfacción con el propio  cuerpo como las dificultades para las relaciones sociales, son indicadores  asociados a los trastornos alimentarios. El objetivo en este trabajo fue  identificar la insatisfacción corporal y los déficits en habilidades sociales  en adolescentes residentes en dos zonas rurales de Tucumán (R. Argentina). Se  realizó un estudio descriptivo-correlacional, diseño experimental, transversal  con muestra intencional. Se realizaron mediciones antropométricas y se  administraron el Inventario de Conductas Alimentarias, la Batería de  Socialización y una encuesta sociodemográfica. Se encontró que el 11%  presentaba sobrepeso y obesidad mientras que alrededor del 43% mostraba  indicadores de deseo de adelgazar e insatisfacción corporal. Los déficits  sociales se vincularon a la presencia de  retraimiento y ansiedad social, particularmente en los adolescentes con  sobrepeso y obesidad. Los adolescentes con insatisfacción corporal presentaban  escasas habilidades de liderazgo y de manejo grupal. (F (1.216) = 3.3, p<.05). Los datos descriptos dan cuenta de que determinadas valoraciones  estéticas y alimentarias están presentes en las comunidades rurales. De allí  que las estrategias de intervención en este grupo contemplen una mirada  integrada del adolescente y su comportamiento alimentario.","palabras_clave":"ADOLESCENCIA|RURAL|HABILIDADES SOCIALES|ALIMENTACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3591,"idioma_id":4,"titulo":"Geographical variability in response to azynphos-methyl in field-collected populations of Cydia pomonella (Lepidoptera: Tortricidae) from Argentina","resumen":"Resistance to insecticides has been related to application history, genetic factors of the pest and the dynamic within the treated area. The aim of this study was to assess the geographic variation in azinphos-methyl response and the role of esterase and cytochrome P450 monooxygenase enzymes in codling moth populations collected within different areas of the RÍo Negro and Neuquén Valley, Argentina.  Diapausing field-collected populations showed resistance ratios at the LC(50) that were 0.7-8.7 times higher than that of the susceptible strain. Mean esterase (EST) and cytochrome P450 monooxygenase activities (expressed as alfa-N min(-1) mg(-1) prot(-1) and pg 7-OHC insect(-1) min(-1) respectively) were significantly correlated with LD(50) values from the field-collected populations. In addition, azinphos-methyl response was associated with the geographic area where the insect population was collected: populations from isolated and more recent productive areas presented significantly lower resistance ratios in comparison with populations from older and more intensive productive areas.The populations assayed presented different resistance levels to azinphos-methyl. The response was highly correlated with the orchard´s geographic location. EST and ECOD activities were involved in azinphos-methyl response in the given region.","palabras_clave":"PESTICIDE|RESISTANCE|ESTERASE|MFO|METABOLISM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3592,"idioma_id":4,"titulo":"?\tDetection of the ompA gene of Chlamydophila pecorum in captive birds, in Argentina.","resumen":"Bacteria belonging to the family Chlamydiaceae cause a broad spectrum of diseases in a wide range of hosts,including humans, other mammals and birds. However, very little is known about chlamydial infections in birds in our region. In the present study, we examined 28 clinically normal birds in illegal captivity that were confiscated in the province of Córdoba, Argentina. The objective was to detect Chlamydophila spp. in cloacal swabs by genetic analysis of the ompA gene. Nested-PCR of the ompA gene identified five samples as Chlamydophila pecorum andthe sequence analysis demonstrated the presence of the ompA gene of C. pecorum in these birds. On the other hand, Chlamydophila psittaci was not detected. These birds could be either asymptomatic reservoirs or subclinical carriers of C. pecorum. This is the first report of the detection of C. pecorum in Argentina.","palabras_clave":"Chlamydophila"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3593,"idioma_id":5,"titulo":"Caracterización y variación intra-específica del néctar floral en Anarthrophyllum desideratum (Fabaceae), un arbusto endémico de la estepa Patagónica polinizado por aves Paseriformes.","resumen":"Summary   Characterization and  intra-specific  variation of  floral  nectar in Anarthrophyllum desideratum   (Fabaceae), an  endemic  shrub of  the  Patagonian  steppe  pollinated  by Passerine  birds.   Anarthrophyllum  desideratum  (DC)  Benth.  is  an  endemic  shrub  of  the  Patagonian  steppe   pollinated by Passerine birds. At the present study, we characterize the volume, concentration   and  sugar  composition  of  floral  nectar,  and  analyze  their  temporal  and  spatial  variation  at   different  levels  (among  plants,  among  populations  and  among  ecological  regions).  By  gas   chromatography,  we  determined  the  proportion  of  glucose,  fructose  and  sucrose.  Nectar   showed, in average, a volume of 8.1 µl, and a concentration of 28 %, and was dominated by   hexoses,  in  line  with  expectations  according  to  the  species  floral  syndrome.  Concentration   was positively associated with sucrose percentage. Nested analyses of  variance revealed that   all characters  varied among populations, and  most of them  varied among ecological regions.   Volume  and  concentration  also  differed  among  individuals  within  populations.  In  all  cases,   differences  among  populations  accounted  for  most  of  the  variability.  Nectar  volume  and   concentration  varied  between  years,  while  sugar  composition  (proportions)  remained   constant. The results suggest that biotic or abiotic  factors acting at a  local  scale could  affect   the variation in nectar attributes of A. desideratum.","palabras_clave":"Anarthrophyllum|néctar |variación geografica|polinización"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3594,"idioma_id":4,"titulo":"Plasma esterases in the  tegu lizard  Tupinambis  merianae  (Reptilia, Teiidae):    impact   of biological variables and organophosphorus in vitro exposure.","resumen":"Purpose In this study, we determined normal serumbutyrylcholinesterase (BChE) and carboxylesterase (CbE)activities in Tupinambis merianae in order to obtain referencevalues for organophosphorus pesticide monitoring.Methods Forty-two T. merianae individuals were groupedby sex and size to identify potential differences in theirenzyme levels to allow for proper representation of normalvalues for females, males, juveniles, and hatchlings. MeanCbE was determined using two model substrates: alpha-naphtylacetate (á-NA) and p-nitrophenyl valerate (4-NPV).BChE and CbE sensitivity to malaoxon (Mx) was alsoevaluated as well as the possibility of BChE reactivationwith pyridine-2-aldoxime methochloride (2-PAM).Results Mean adult females\u2019 BChE was significantly higherthan adult males, juveniles, and hatchlings. No significantdifferences were found between groups regarding CbE.CbE (4-NPV) activity showed slightly negative correlationwith lizard snout\u2013vent length, while BChE and CbE (á-NA)showed no correlation with body size. Apparent IC50 valuesfor BChE and CbE (á-NA) suggested different sensitivitiesamong groups. CbE (4-NPV) could not be inhibited. AllMx-inhibited groups treated with 2-PAM in a final concen-tration of 2.8 mM showed clear signs of reactivation.Conclusions In conclusion, the results demonstrate that (1)plasma esterase activity did not vary with age and sex,except for BChE activity, and (2) because biological andenvironmental variables could be confounding factors in theresponse of plasma cholinesterases, complementary bio-markers like CbE inhibition and oxime-induced reactivationof esterases are strongly recommended.","palabras_clave":"Tupinambis|b sterases|organophosphorous|developmental stage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3596,"idioma_id":4,"titulo":"Comparative Analysis of MIS Capacitance Structures With High-k Dielectrics Under Gamma,  ^{16} O and p Radiation","resumen":"Abstract&nbsp;&nbsp; -&nbsp; MIS&nbsp;&nbsp; capacitance&nbsp;&nbsp; structures,&nbsp; with&nbsp; Hafnium Oxide, Alumina&nbsp;&nbsp; and&nbsp;&nbsp; nanolaminate&nbsp;&nbsp; as&nbsp;&nbsp; dielectrics&nbsp; were&nbsp;&nbsp; studied&nbsp;&nbsp; under gamma photons&nbsp; 60 Co, 25 MeV oxygen ions and 10 MeV protons radiation using capacitance-voltage (C-V) characterization. The main&nbsp; trend of&nbsp;&nbsp; the results shows&nbsp; that&nbsp;&nbsp; the nanolaminates stack presents the highest levels of hysteresis and stretch-out of the&nbsp;&nbsp; C-V&nbsp;&nbsp; curves,&nbsp;&nbsp; suggesting&nbsp;&nbsp; that&nbsp;&nbsp; interface&nbsp;&nbsp; layers&nbsp;&nbsp; between dielectrics could play a relevant role in the study of the radiation response.","palabras_clave":"High-k gate dielectrics|MOS devices|radiation effects"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3597,"idioma_id":4,"titulo":"Production, recovery and purification of a recombinant &#946;-galactosidase by expanded bed anion exchange adsorption","resumen":"-Galactosidase is a hydrolase enzyme that catalyzes the hydrolysis of -galactosides into monosaccharides; its major application in the food industry is to reduce the content of lactose in lactic products. The aim of this work is to recover this enzyme from a cell lysate by adsorption onto Streamline-DEAE in an expanded bed, avoiding, as much as possible, biomass deposition onto the adsorbent matrix. So as to&nbsp; achieve less cell debris\u2013matrix interaction, the adsorbent surface was covered with polyvinyl pyrrolidone.&nbsp; The enzyme showed to bind in the same extent to naked and covered Streamline-DEAE (65 mg&nbsp; -gal\/g matrix) in batch mode in the absence of any biomass. The kinetics of the adsorption process was studied and no effect of the polyvinyl pyrrolidone covering was found. The optimal conditions for the recovery were achieved by using a lysate made of 40% wet weight of cells, a polyvinyl pyrrolidone-covered matrix\/lysate ratio of 10% and carrying out the adsorption process in expanded bed with recirculation over 2 h in 20 mM phosphate buffer pH 7.4. The fraction recovered after the elution contained 65% of&nbsp; the initial amount of enzyme with a 12.6-fold increased specific activity with respect to the lysate. The&nbsp; polyvinyl pyrrolidone content in the eluate was determined and found negligible. The remarkable point&nbsp; of this work is that it was possible to partially purify the enzyme using a feedstock containing an unusually high biomass concentration in the presence of polyvinyl pyrrolidone onto weak anion exchangers.-Galactosidase is a hydrolase enzyme that catalyzes the hydrolysis of -galactosides into monosaccharides; its major application in the food industry is to reduce the content of lactose in lactic products. The aim of this work is to recover this enzyme from a cell lysate by adsorption onto Streamline-DEAE in an expanded bed, avoiding, as much as possible, biomass deposition onto the adsorbent matrix. So as to&nbsp; achieve less cell debris\u2013matrix interaction, the adsorbent surface was covered with polyvinyl pyrrolidone.&nbsp; The enzyme showed to bind in the same extent to naked and covered Streamline-DEAE (65 mg&nbsp; -gal\/g matrix) in batch mode in the absence of any biomass. The kinetics of the adsorption process was studied and no effect of the polyvinyl pyrrolidone covering was found. The optimal conditions for the recovery were achieved by using a lysate made of 40% wet weight of cells, a polyvinyl pyrrolidone-covered matrix\/lysate ratio of 10% and carrying out the adsorption process in expanded bed with recirculation over 2 h in 20 mM phosphate buffer pH 7.4. The fraction recovered after the elution contained 65% of&nbsp; the initial amount of enzyme with a 12.6-fold increased specific activity with respect to the lysate. The&nbsp; polyvinyl pyrrolidone content in the eluate was determined and found negligible. The remarkable point&nbsp; of this work is that it was possible to partially purify the enzyme using a feedstock containing an unusually high biomass concentration in the presence of polyvinyl pyrrolidone onto weak anion exchangers.","palabras_clave":"BETA-GALACTOSIDASE|STREAMLINE-DEAE|EXPANDED BED ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3598,"idioma_id":4,"titulo":"Exploring the cyclooxygenase 2 (COX2)\/15d delta12,14PGJ2 system in hamster Sertoli cells: regulation by FSH\/testosterone and relevance to glucose uptake.","resumen":"We have previously described a stimulatory effect of testosterone on cyclooxygenase 2 (COX2) expression and prostaglandin (PG) synthesis, and the involvement of PGs in the modulation of testosterone production in Leydig cells of the seasonal breeder Syrian hamster. In this study, we investigated the existence of a COX2\/PGs system in hamster Sertoli cells, its regulation by testosterone and FSH, and its effect on glucose uptake. COX2 expression was observed in Sertoli cells of both reproductively active and inactive adult hamsters. Testosterone and the plasma membrane-impermeable testosterone-BSA significantly induced COX2 expression, mitogen activated protein kinases 1\/2 (MAPK1\/2) phosphorylation and 15d-delta12,14PGJ2 production in Sertoli cells purified from photoperiodically regressed hamsters. These actions were abolished by the antiandrogen bicalutamide and by the inhibitor of MAPK kinase (MEK1\/2) U0126, suggesting that testosterone exerts its stimulatory effect on COX2\/PGs through a non-classical mechanism that involves the presence of androgen receptors and MAPK1\/2 activation. FSH also stimulated COX2\/PGs via MAPK1\/2 phosphorylation. FSH and testosterone stimulate, whereas 15d-delta12,14PGJ2 via PPAR inhibits, [2,6-3H]-2-deoxy-D-glucose ([3H]-2-DOG) uptake. Meloxicam, a selective COX2 inhibitor, further increases [3H]-2-DOG uptake in the presence of FSH or testosterone. Thus, in addition to their positive effect, FSH and testosterone may also exert an indirect negative regulation on glucose uptake which involves the COX2\/15d-delta12,14PGJ2\/PPARs system. Overall, these results demonstrate the presence of a COX2\/PG system in hamster Sertoli cells which might act as a local modulator of FSH and testosterone actions.","palabras_clave":"cyclooxygenase 2|testosterone|FSH |15d delta12,14PGJ2 |Sertoli cells|hamsters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3599,"idioma_id":5,"titulo":"Virus de la inmunodeficiencia felina (FIV): actualización en la terapéutica antiviral. Feline immunodeficiency virus: therapy update.","resumen":"El Virus de la Inmunodeficiencia Felina (FIV) es un lentivirus que infecta a los gatos salvajes y domésticos a nivel mundial. Los pacientes presentan signos clínicos similares a los producidos en el hombre por el virus de la Inmunodeficiencia humana (VIH), desarrollando un cuadro final de inmunosupresión denominado síndrome de inmunodeficiencia adquirida (SIDA). Es por eso que el felino resulta un excelente modelo experimental para evaluar drogas anti-VIH in vivo. El mejor resultado obtenido en el tratamiento del hombre es con combinaciones de drogas que actúen en los diversos puntos críticos de la replicación viral. Dichos tratamientos son conocidos como terapia antirretroviral de elevada eficiencia. En los gatos infectados por FIV se han probado muchas drogas, pero se han hecho muy pocos estudios clínicos con la intención de establecer protocolos eficientes y poco tóxicos para el gato. El principal objetivo de este artículo es actualizar los conocimientos relativos a la terapia antirretroviral, sus efectos desfavorables y su efectividad.","palabras_clave":"TERAPIA ANTIRRETROVIRAL|VIF|HAART"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":3601,"idioma_id":4,"titulo":"Sulfated ƒÒ-D-mannan from the green seaweed Codium vermilara","resumen":"b-(1&#8594;4)-d-Mannans constitute the major component of the cell wall of seaweeds of the genus Codium and replace cellulose as the major fibrillar component. They were found as major constituents of the hot water extracts of green seaweed Codium vermilara. By anion exchange chromatography of the first hot water extract, a pure sulfated mannan with a molar ratio carbohydrates:sulfate of 2.7:1 was isolated. The sulfate groups are linked to C-2 of 23% of the mannose units, while most of these units are not substituted. This degree of sulfation would explain the higher solubility of the polymer, compared to that of the nonsulfated fibrillar mannan. Taking into account that the fibrillar polysaccharides form two external layers in the cell wall, while the sulfated polymers are forming an amorphous central layer, it is postulated that these sulfated mannans could act as an interphase region between the neutral and acidic layers.","palabras_clave":"mannans|algal cell wall|sulphated polysacchaarides|green algae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":19480,"idioma_id":5,"titulo":"'Presentación'","resumen":"Presentación del N° 7 de la Revista Temas de Mujeres, Revista del Cehim que se edita por primera vez en soporte papel (ISSN 2250-6705), por parte de las editoras","palabras_clave":"TEORIA ORGANIZACIONAL|PENSAMIENTO CRITICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":25158,"idioma_id":5,"titulo":"Decisiones didácticas al seleccionar y organizar los contenidos para los cursos de ?Inglés para Propósitos específicos en carreras de orientación humanística?,","resumen":"El propósito de este trabajo es ampliar la caracterización presentada en trabajos previos sobre la propuesta curricular para los Cursos de Inglés para Propósitos Específicos en Carreras de la Facultad de Ciencias Humanas de la Universidad Nacional de San Luis. Considerando el entorno exolingüe se explicitan y justifican la selección y la organización de los contenidos en base a conocimientos de valor declarativo, procedural y condicional desde un enfoque didáctico contextualizado con aportes de una pedagogía basada en género.","palabras_clave":"PRÁCTICAS SOCIALES DE REFERENCIA|PROPÓSITOS Y TAREAS DE LECTURA|TEXTOS ACADÉMICO-CIENTÍFICOS|ESTRATEGIAS Y RECURSOS PARA LA COMPRENSIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":54036,"idioma_id":5,"titulo":"Entre médicos y juristas. La medicina en los orígenes del derecho laboral. Córdoba, 1906-1943","resumen":"El presente trabajo tiene como objetivo analizar la penetración de los saberes médicos en el proceso de constitución del derecho laboral como una disciplina especializada. Para ello, se focaliza en la obra y la trayectoria de un grupo de abogados laboralistas del espacio académico cordobés en el período comprendido entre 1906 y 1943. En particular, se pretende establecer qué argumentos y prácticas de la medicina legal, la psiquiatría y la fisiología fueron incorporados por el derecho laboral para el análisis de la fatiga del obrero y la naturaleza de los accidentes y enfermedades del trabajo. El propósito es explicar el impacto de los conocimientos y técnicas de la medicina en los estudios elaborados por los abogados laboralistas sobre estas problemáticas del mundo del trabajo.","palabras_clave":"Saberes médicos|Derecho laboral|Medicina legal|Fisiología"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":55397,"idioma_id":5,"titulo":"El plano de la distancia como dimensión estructural en la música","resumen":"El presente trabajo trata sobre el manejo del espacio sonoro en la! música. Específicamente es revisado el plano auditivo de distancia y  su relación con la composición musical tanto instrumental como electroacústica. En primera instancia se presenta una breve revisión de  los avances científicos relacionados con los indicios involucrados en la percepción auditiva de distancia. En segundo lugar realizamos una   revisión de algunas estrategias utilizadas por compositores para simular la ubicación de fuentes sonoras en el plano de distancia tanto en ambientes reales como virtuales. Por último desarrollamos conceptos sobre la creación del espacio sonoro a través de múltiples capas sonoras como también mediante la utilización de fuentes fijas de referencia.","palabras_clave":"COMPOSICIÓN |MÚSICA|PERCEPCIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":55735,"idioma_id":5,"titulo":"Leyendo a Juanito Laguna","resumen":"Nuestro propósito en este trabajo es hacer una ?lectura? de la pintura de Antonio Berni ?Juanito Laguna aprende a leer? (1961). Nuestro interés se centra en pensar a la lectura desde las imágenes que nos ofrece el artista; para ello intentaremos adentrarnos en la obra entre las pinceladas y las texturas, el óleo y la arpillera, a partir del diálogo con diversos autores que nos permiten reflexionar sobre la lectura atendiendo al contexto, a los lectores y a los textos que se presentan.","palabras_clave":"LECTURA|JUANITO LAGUNA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":60790,"idioma_id":5,"titulo":"Jurisprudencia Anotada","resumen":"El presente trabajo,  trata la oposición a la celebración del matrimonio formulada por el hijo contra su padre de ochenta y seis años quien pretende contraer nupcias con una mujer de cuarenta y seis, con fundamento en el síndrome mental por edad avanzada. El mismo encuentra  fundamento en el art. 166, inc. 8, del Código Civil. Que establece ?Son impedimentos para contraer matrimonio: ?. 8. La privación permanente o transitoria de la razón, por cualquier causa que fuere?.El novio objeto de oposición por su descendiente, al celebrarse la audiencia a fin de evaluar su capacidad;  no presentó signos de privación transitoria o temporal que vicie el consentimiento, por su avanza edad, lo que en la apreciación personal juez interviniente y de acuerdo a la opinión del médico forense no se observó minusvalía alguna que pueda impedirle comprender el alcance del matrimonio.La ancianidad, por su  condición de tal, generalmente encuentra debilitada su voluntad y padece a menudo de cierta desprotección o discriminación; lo que la ubica en situación de vulnerabilidad La vulnerabilidad de los ancianos en su voluntad se advierte de manera clara  ante diversas situaciones en las cuales se ven impotentes de poder ejercer sus propios derechos, aún gozando de capacidad pues la misma les es desconocida, incluso por sus propios familiares, simplemente por su edad.","palabras_clave":"Testamento|Ológrafo|Requisitos|Firma"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":63045,"idioma_id":4,"titulo":"LEAD NITROPRUSSIDE: A NEW PRECURSOR FOR THE SYNTHESIS OF THE MULTIFERROIC Pb2Fe2O5, AN ANION DEFFICIENT PEROVSKITE","resumen":"In order to investigate the formation of multiferroic oxide Pb2Fe2O5, the thermal decomposition of Pb[Fe(CN)5NO] has been studied. The complex precursor and the thermal decomposition products were characterized by IR and Raman spectroscopy, thermal analysis, powder X-ray diffraction (PXRD), scanning electron microscopy and magnetic measurements. The crystal structure of Pb[Fe(CN)5NO] was refined by Rietveld analysis. It crystallizes in the orthorhombic system, space group Pnma. The thermal&nbsp; decomposition in air produces highly pure Pb2Fe2O5 as final product. This oxide is an anion deficient perovskite with an incommensurate superstructure. The magnetic measurements confirm that Pb2Fe2O5 shows a weak ferromagnetic signal probably due to disorder in the perfect antiferromagnetic structure or spin canting. The estimated ordering temperature from the fit of a phenomenological model was 520 K. The SEM images reveal that the thermal decomposition of Pb[Fe(CN)5NO] produces Pb2Fe2O5 with small particle size.","palabras_clave":"THERMAL DECOMPOSITION|LEAD NITROPRUSSIDE|RIETVELD ANALYSIS|MULTIFERROIC Pb2Fe2O5|VIBRATIONAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":63639,"idioma_id":4,"titulo":"Mapping and candidate gene identification of loci determining tolerance to greenbug (Schizaphis graminum, Rondani) in barley","resumen":"The Russian wheat aphid (RWA) is one ofthe most aggressive pests of barley and wheat. Theoutbreak of RWA occurred in Argentina in 2008caused serious damage to barley cultivars. The mosteffective and sustainable method of RWA control is toidentify new resistance genes. The purpose of thecurrent research was to map RWA resistance genes ina set of double haploid (DH) lines of the Oregon-Wolfe Barley (OWB) mapping population derivedfrom the cross between OWBDOM and OWBREC. TheDH and both parental lines were screened for antixenosis,tolerance and antibiosis to RWA. There wassignificant variation among the DH lines in most of thetraits studied. However, only tolerance resulted insignificant quantitative trait loci (QTLs) associatedwith the molecular markers. Two main QTLs wereidentified. These explained 90 and 79 % of thevariability of foliar area and chlorophyll content,respectively, of infested and control plants. The initialand final foliar area and the variation in foliar areawere associated with the same molecular markers onchromosome 2H (BmAc0125, Vrs1, BmAc0144f andBmAg0113e). The positive alleles were provided byOWBDOM. The content of chlorophyll was associatedwith the marker loci WMC1E8, MWG912, ABC261,MWG2028 and Blp on chromosome 1H, with thepositive alleles provided by OWBREC. Both parentscontributed to different tolerance traits, with foliararea and chlorophyll content remaining as the planttraits most affected by aphid feeding. The QTLs foundin this population are new RWA resistance loci. Asequence homology search was performed to derivethe putative function of the genes linked to the QTLs.Keywords Molecular markers  RWA  Barley Tolerance  Candidate genes  Quantitative trait locus","palabras_clave":"Marker Assisted Selection  |QTLs,|Candidate genes|Hordeum vulgare."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":63665,"idioma_id":4,"titulo":"Vertebrate Succession in the Ischigualasto Formation","resumen":"The Upper Triassic (Carnian?Norian) Ischigualasto Formation has yielded a diverse vertebrate fauna that records the initial phase of dinosaur evolution. Radioisotopic dates from ash layers within the formation provide a chronostratigraphic framework, and stratigraphic and sedimetological studies have subdivided the formation into four members and three abundance-based biozones. We describe two new basal dinosauromorphs, an unnamed lagerpetid and a new silesaurid, Ignotosaurus fragilis, gen. et sp. nov., which increase to 29 the number of vertebrates in the Ischigualasto fauna. We provide a census of 848 fossil specimens representing 26 vertebrate taxa logged to stratigraphic intervals of 50 m. This temporally calibrated census shows that abundance and taxonomic diversity within the Ischigualasto Formation does not change suddenly but rather appears to gradually decline in response to climatic deterioration. The only abrupt shift in faunal composition occurs at the end of the second of three biozones, when the abundant cynodont Exaeretodon is replaced by the rare dicynodont Jachaleria.","palabras_clave":"Triassic|Carnian|Ischigualasto|Vertebrate succession"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":65546,"idioma_id":4,"titulo":"Virulence factors of the Mycobacterium tuberculosis complex","resumen":"The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humansand animals. This illness, still today, remains to be one of theleading causes of morbidity and mortality throughout theworld. The mycobacteria enter the host by air, and, once in thelungs, are phagocytated by macrophages. This may lead to therapid elimination of the bacillus or to the triggering of anactive tuberculosis infection. A large number of differentvirulence factors have evolved in MTBC members as aresponse to the host immune reaction. The aim of this reviewis to describe the bacterial genes\/proteins that are essential forthe virulence of MTBC species, and that have been demonstratedin an in vivo model of infection. Knowledge of MTBCvirulence factors is essential for the development of newvaccines and drugs to help manage the disease toward anincreasingly more tuberculosis-free world.closely related species that cause tuberculosis in both humansand animals. This illness, still today, remains to be one of theleading causes of morbidity and mortality throughout theworld. The mycobacteria enter the host by air, and, once in thelungs, are phagocytated by macrophages. This may lead to therapid elimination of the bacillus or to the triggering of anactive tuberculosis infection. A large number of differentvirulence factors have evolved in MTBC members as aresponse to the host immune reaction. The aim of this reviewis to describe the bacterial genes\/proteins that are essential forthe virulence of MTBC species, and that have been demonstratedin an in vivo model of infection. Knowledge of MTBCvirulence factors is essential for the development of newvaccines and drugs to help manage the disease toward anincreasingly more tuberculosis-free world.closely related species that cause tuberculosis in both humansand animals. This illness, still today, remains to be one of theleading causes of morbidity and mortality throughout theworld. The mycobacteria enter the host by air, and, once in thelungs, are phagocytated by macrophages. This may lead to therapid elimination of the bacillus or to the triggering of anactive tuberculosis infection. A large number of differentvirulence factors have evolved in MTBC members as aresponse to the host immune reaction. The aim of this reviewis to describe the bacterial genes\/proteins that are essential forthe virulence of MTBC species, and that have been demonstratedin an in vivo model of infection. Knowledge of MTBCvirulence factors is essential for the development of newvaccines and drugs to help manage the disease toward anincreasingly more tuberculosis-free world.closely related species that cause tuberculosis in both humansand animals. This illness, still today, remains to be one of theleading causes of morbidity and mortality throughout theworld. The mycobacteria enter the host by air, and, once in thelungs, are phagocytated by macrophages. This may lead to therapid elimination of the bacillus or to the triggering of anactive tuberculosis infection. A large number of differentvirulence factors have evolved in MTBC members as aresponse to the host immune reaction. The aim of this reviewis to describe the bacterial genes\/proteins that are essential forthe virulence of MTBC species, and that have been demonstratedin an in vivo model of infection. Knowledge of MTBCvirulence factors is essential for the development of newvaccines and drugs to help manage the disease toward anincreasingly more tuberculosis-free world.Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humansand animals. This illness, still today, remains to be one of theleading causes of morbidity and mortality throughout theworld. The mycobacteria enter the host by air, and, once in thelungs, are phagocytated by macrophages. This may lead to therapid elimination of the bacillus or to the triggering of anactive tuberculosis infection. A large number of differentvirulence factors have evolved in MTBC members as aresponse to the host immune reaction. The aim of this reviewis to describe the bacterial genes\/proteins that are essential forthe virulence of MTBC species, and that have been demonstratedin an in vivo model of infection. Knowledge of MTBCvirulence factors is essential for the development of newvaccines and drugs to help manage the disease toward anincreasingly more tuberculosis-free world.","palabras_clave":"Virulence |Mycobacterium tuberculosis complex|tuberculosis|review"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":65862,"idioma_id":4,"titulo":"Cryptic homoeology analysis in species and hybrids of genus Zea","resumen":"Cryptic intergenomic pairing of genus Zea was induced by the use of a diluted colchicine solution in order to elucidate the phylogenetic relations and differentiation of the homoeologous genomes. Results indicate that in species and hybrids with 2n = 20, there was chromosome pairing between the homoeologous A and B genomes with a maximum of 5IV, with the exception of Zea diploperennis and their interspecific hybrids where cryptic homoeologous chromosome pairing was not induced. In almost all 2n = 30 hybrids, observed cryptic pairing increased to a maximum of 10III although Z. mays × Z. mays with 2n = 30 did not show significant differences between treated and untreated materials. Pairing was also observed in species and hybrids with 2n = 40, in which a maximum of 10IV was observed, with the exception of Z. mays with 2n = 40 where treated and untreated cells did not differ significantly.","palabras_clave":"Colchicine|Genome|Maize|Subgenome|Toesinte"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":66171,"idioma_id":4,"titulo":"Aspergillus kawachii produces an inulinase in cultures with yacon (Smallanthus sonchifolius) as substrate","resumen":"Abstract  Background: Inulinases have been extracted and characterized from inulin-storing tissues;  however, production of microbial inulinases have recently draw much attention as they offer  several industrial advantages. Many microorganisms, including filamentous fungi, yeast and  bacteria have been claimed as inulinase producers. These hydrolases are usually inducible and  their exo-acting forms may hydrolyze fructose polymers (inulin) and oligosaccharides such as  sucrose and raffinose. Fungal inulinase extracts are often produced as stable mixture of highly active fructanhydrolases. From a practical prospective, the best known inulinases to date are  those produced by species of Penicillium, Aspergillus and Kluyveromyces.    Results: The production of extracellular inulinase by A. kawachii in liquid cultures, using either  inulin or yacon derived materials as CES as well as inulinase inducers, is reported. In addition,  a partial characterization of the enzyme activity is included.    Conclusions: Yacon derived products, particularly yacon juice, added to the culture medium  proved to be a good CES for fungal growth as well as an inducer of enzyme synthesis. Partial  characterization of the enzyme revealed that it is quite stable in a wide range of pH and  temperature. In addition, characterization of the reaction products revealed that this enzyme  corresponds to an exo-type. These facts are promising considering its potential application in  inulin hydrolysis for the production of high fructose syrups.","palabras_clave":"ACIDOPHILIC ENZYMES|BATCH CULTURES|INULIN DEGRADATION|SUBMERGED CULTURES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":66228,"idioma_id":4,"titulo":"Effect of damaged starch on the rheological properties of wheat starch suspensions","resumen":"The influence of damaged starch content on particle size distribution and rheological properties of unheated starch suspensions and pasting properties were investigated. Four samples containing different amounts of damaged starch were studied. Particle size distribution curves shifted toward higher diameters, and a greater overlap of both populations of particles (A- and B-type granules) and a decrease of both peak heights were produced. The flow curves of unheated starch suspensions were fitted using the power law model. The flow behavior indexes were higher than the unit. The consistency coefficient increased with the increment of damaged starch content. Unheated starch suspensions showed time-dependent rheological behavior and were described by the Weltman model. The unheated suspensions exhibited a thixotropic behavior. With regard to the pasting process, the increment of damaged starch content produced gradual reductions in peak viscosity, final paste viscosity, breakdown and setback. Results demonstrated the importance of the presence of physically damaged granules in wheat starch rheological characteristics. © 2012 Elsevier Ltd. All rights reserved.","palabras_clave":"starch|starch damaged|rheology|suspensions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":66268,"idioma_id":4,"titulo":"Reproductive Impairment of a Viviparous Fish Species Inhabiting a Freshwater System with Anthropogenic Impact","resumen":"The potential threat to animal reproduction by  10 contaminated freshwater systems posed the necessity to  11 identify and develop bioindicators and biomarkers to be  12 used for screening and evaluation of the effects in organisms.  13 The main goal of this work was to determine, through  14 histological analyses and changes in gonopodium morphol-  15 ogy, whether a freshwater system polluted by anthropo-  16 genic activities?sewage, agricultural, and industrial?  17 could cause alterations at the organ level. We also propose  18 the live-bearing fish, Jenynsia multidentata, as a species  19 suitable to study the effects of contaminated aquatic envi-  20 ronments. We compared male fish sampled at two different  21 stations in Suqu&#305;´a River basin (Co´rdoba, Argentina), both  22 differing in degree of pollution, through liver and testis  23 histology and gonopodial morphometric parameters. The  24 water quality, based on the physicochemical characteristics  of the studied stations, varied markedly with a decrease in 25  water quality at the downstream site (station 2). At the 26  highest polluted area, detrimental effects on liver and testis 27  were evidenced on histological analysis. Male individuals 28  from station 2 also presented noticeable structural changes of 29  the anal fin, such as a straight gonopodium and abnormal 30  tip area. The present results demonstrate that a freshwater 31  system polluted by the impacts of anthropogenic activities 32  has detrimental effects to J. multidentata. The alterations 33  registered in individuals from the polluted station indicate 34  an impairment of male reproductive performance and imply 35  a risk for other live-bearing species as well as the entire 36  biodiversity. We consider J. multidentata a sentinel species 37  that is useful to evaluate the potential risk present in the 38  studied basin not only to itself but to other species as well.","palabras_clave":"Reproductive Impairment|FISH|VIVIPAROUS|GONOPODIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":66424,"idioma_id":5,"titulo":"Bacterias subgingivales aisladas de perros con enfermedad periodontal y su susceptibilidad a antimicrobianos. Primera comunicación en la República Argentina","resumen":"La microbiota subgingival relacionada con la enfermedad periodontal en el perro ha sido estudiada pero solo existen investigaciones realizadas en el exterior. En el conocimiento de los autores no hay trabajos sobre este tema en nuestro medio. Por ello se decidió estudiar la microbiota subgingival y su sensibilidad a antimicrobianos en pacientes caninos con enfermedad periodontal de ocurrencia espontánea, que debieran ser sometidos a tratamiento en el Servicio de Cirugía del Hospital Escuela de Medicina Veterinaria (HEMV) y en el Servicio de Odontología y Cirugía Máxilofacial, Facultad de Ciencias Veterinaria, UBA. De un total de 54 sitios provenientes de 18 perros, previa determinación del grado de periodontitis, se tomaron muestras subgingivales con cureta de Gracey y se aislaron 105 microorganismos (79 aerobios y anaerobios facultativos y 28 anaerobios estrictos). En aquellos sitios con bolsillos periodontales más profundos (mayores a 4 mm) se aislaron más frecuentemente bacterias anaerobias estrictas. Se determinó sensibilidad a antimicrobianos según Clinical and Laboratory Standards Institute (CLSI ). Ninguno de los microorganismos aislados presentó resistencia a amoxicilina\/ácido clavulánico, gentamicina, vancomicina, clindamicina o metronidazol. Al no estar disponibles datos de este tipo en nuestro país, los resultados obtenidos en el presente estudio podrán ser de utilidad en el tratamiento de perros afectados.","palabras_clave":"BACTERIAS SUBGINGIVALES|PERRO|ENFERMEDAD PERIODONTAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":67670,"idioma_id":4,"titulo":"Corrosion resistance of commercial metallic materials in contact with mortar","resumen":"The objective of the present work is to examine the corrosion behaviour of the following materials: copper, lead,aluminium, zinc, stainless steel (AISI 304) and carbon steel (SAE 1040), when they are in contact with mortar, with andwithout the addition of chloride ions. Mortar specimens containing bars of these materials have been made. In addition,these specimens have been contaminated with chloride ions in different concentrations: 0, 0.3 % and 1 % (chloride ionmass by mass of cement). These specimens have been exposed to different conditions: laboratory, with a relative humidity(RH) of 45 %; curing chamber (98% RH) and immersed in a solution of 3.5 wt.% NaCl. The electrochemical parametersnormally used to characterize the corrosion behaviour of reinforcing steel in concrete have been monitored periodically.These parameters include the corrosion potential (Ec), the polarization resistance (Rp) and the electrical resistivity ofmortar ( ). Also, the carbonation rate was determined in order to evaluate the resistance of the mortar to the ingress ofcarbon dioxide. Among the materials studied, the stainless steel has hitherto presented the best behaviour againstcorrosion, in all conditions tested. Specimens made with aluminium bars and contaminated with 1% chloride ionpresented cracks and partial mortar cover detachment due to the effect of voluminous aluminium corrosion products.","palabras_clave":"CORROSION|MORTAR|METALLIC MATERIALS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":67964,"idioma_id":4,"titulo":"Sabellaria nanella (Sabellariidae): from solitary subtidal to intertidal reef-building worm at Monte Hermoso, Argentina (39 °S, south-west Atlantic)","resumen":"This contribution reports the first record of intertidal reefs built by the sabellariid worm Sabellaria nanella in the lower intertidal at Monte Hermoso beach, Argentina (39ºS). All previous records of S. nanella in the study area correspond to solitary individuals from shallow subtidal depths in coastal environments, while the present findings refer to well established reefs on stony rocks. Worms sort medium size sand grains to build the reefs, which contain higher amount of organic matter than the surrounding sediments. Size structure of worms shows multiple size cohorts that include recent recruits and mature adults. Many invertebrates, i.e. various annelids, arthropods, molluscs, nemerteans and nematodes, are the frequent organisms living within the reef, some of them already recorded in the area. The presence of intertidal reefs of S. nanella indicates that the species has plasticity to adapt to environments with different physical conditions (subtidal-intertidal areas).","palabras_clave":"SABELLARIA NANELLA|REEFS|INTERTIDAL|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":68337,"idioma_id":5,"titulo":"?Acontecimiento, alteridad y vivencia: una propuesta de indagación materialista y una política ?responsable? para la investigación-intervención?","resumen":"Uno de los problemas más complejos en la investigación\/intervención es plantear el ?encuentro? con el ?otro? en campo. Algunas preguntas que surgen como instancias previas a toda interacción se dirigen a pensar el lugar que ocupan las problemáticas vinculadas a la  corporalidad(es)\/subjetividad(es) que se ponen en juego: ¿Cómo trabajar los límites impuestos por lo externo\/interno de cada conciencia subjetiva? ¿Cómo desandar sin imponer la mirada que clasifica absorbiendo lo ?otro? en totalidades cerradas? ¿De qué manera es posible ?si lo es- practicar el diálogo en el marco de la violencia atada a toda interpretación?  El presente trabajo reflexiona sobre las posibles constituciones de subjetividades\/corporalidades que se configuran en torno a experiencias de encuentro que parten del reconocimiento de la alteridad como operador del acontecimiento. Las preguntas antes enunciadas y ancladas en situaciones específicas, devuelven ?en la instancia imaginaria de pensar el encuentro- la mirada a nuestra propia configuración social y subjetiva como agentes sociales particulares en los procesos de investigación-intervención. Es en la propuesta bajtiniana de una filosofía participativa (donde las vivencias se construyen a partir de la tensión producida por la alteridad constitutiva de todo individuo) donde encontramos algunas claves para pensar estrategias metodológicas de 'intervención' guiadas por la trama que estructura la posibilidad de toda vivencia (y su materialización): acontecimiento-lenguaje-praxis social.Indexación: Latindex Catálogo","palabras_clave":"ACONTECIMIENTO|ALTERIDAD|VIVENCIA|PRAXIS INVESTIGATIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":69216,"idioma_id":5,"titulo":"Biomarcadores circulantes y tisulares en pacientes con Carcinoma Celular Renal de células claras (CCRcc)","resumen":"En la Argentina el Carcinoma de Células Renales es la 9na causa de muerte por cáncer en varones y la 13ava en mujeres. El CCRcc es el tipo histológico más frecuente y comprende un grupo heterogéneo de cánceres con evolución clínica variable. A nivel molecular, se ha demostrado que el CCRcc está asociado a la desregulación de vías metabólicas involucradas en el censado de la concentración de oxígeno, nutrientes y energía. En particular, la mutación del gen VHL, relacionada con el 60-80% de los casos esporádicos de CCRcc, desencadena la expresión de genes relacionados con la angiogénesis y el metabolismo celular. Si bien las nuevas metodologías moleculares han permitido descubrir nuevos biomarcadores, no se conocen, hoy en día, nuevos marcadores pronósticos con utilidad clínica. Por lo tanto, el objetivo de este estudio fue determinar si la expresión de moléculas específicas, a nivel tisular y sérico, se asocian con parámetros clínicos y\/o patológicos relevantes en CCRcc, incluyendo supervivencia.  En primer lugar, se encaró un estudio retrospectivo, donde se estudió la expresión  de las moléculas VEGFR1\/Flk-1, VEGFR2\/Flt-4 y PDGF-A, asociadas con las vías de señalización gatilladas bajo condiciones de hipoxia, y de la molécula GLUT-1, involucrada en el metabolismo de glucosa. Se encontró que una alta expresión de VEGFR-2, a nivel citoplasmático, se asocia con la presencia de metástasis al diagnóstico. Por otro lado, el estudio univariado indicó que la expresión de GLUT-1 y VEGFR-2 están asociadas con la supervivencia global.  Basado en el conocimiento de que las moléculas circulantes pueden reflejar la biología tumoral, se estudió en forma prospectiva  la expresión de 43 citoquinas angiogénicas, mediante ?antibody array? en el suero de pacientes CCRcc  y controles sanos. Se demostró que el suero de pacientes portadores de CCRcc presenta variaciones en moléculas asociadas con el fenómeno proinflamatorio, como I-309 (CCL1), IL-1&#61537;, IL-1&#61538; y IL-2. Observamos que las citoquinas séricas proinflamatorias disminuyen en pacientes con tumores localizados (EI), con respecto a los individuos control, pero aumentan en pacientes con tumores avanzados (EIV). Por lo tanto, es probable que en tumores de estadios bajos se origine una respuesta que provoque la disminución del perfil de moléculas proinflamatorias que se refleje en la circulación, pero a medida que el tumor progresa se cree un microambiente más hostil que induzca el aumento en la concentración de estas moléculas.  Finalmente, se estudió la expresión sérica de la enzima Anhidrasa Carbónica IX (CAIX) cuya función es participar en la homeostasis del pH intra y extracelular. Se observó que los pacientes portadores de CCRcc presentaron valores significativamente elevados de CAIX circulante  respecto a los observados en controles sanos. Considerando un valor de corte correspondiente al percentilo 85 de la población control (34,82 pg\/ml), la Especificidad de CAIX para la portación de CCRcc fue de 93,8% y la Sensibilidad de 73,3%. Además, se encontró que los pacientes EI mostraron valores de CAIX sérica significativamente menores con respecto a los valores observados en pacientes con estadios más avanzados. En el 66,67% de los pacientes se observó que los valores de CAIX descendieron significativamente luego de la cirugía. Por lo tanto, la cuantificación de CAIX sérica podría ser un potencial marcador para el diagnóstico y seguimiento de pacientes con CCRcc.   Consideramos que estudios realizados son de relevancia, ya que para el CCRcc no se cuenta, hasta el momento, con biomarcadores de utilidad clínica en el manejo del paciente.","palabras_clave":"CANCER_DE_RIÑON|ENZYMA_CAIX|VIAS_ANGIOGENICAS|MARCADORES_TUMORALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":69336,"idioma_id":4,"titulo":"Accumulation of aluminium and physiological status of tree foliage in the vicinity of a large aluminium smelter in Argentina","resumen":"    A  pollution gradient was observed in tree foliage sampled in the vicinity of a  large aluminium production facility in Patagonia (Argentina). Leaves of Eucalyptus rostrata, Populus hybridus and  different needle ages of Pinus spec.  were collected and concentrations of aluminium (Al) and sulphur (S) as well as  physiological parameters (Chlorophyll and lipid oxidation products)  were analyzed. Al and S-  concentrations indicate a steep pollution gradient in the study area but  physiological parameters were unrelated to these elements. The  present study confirms that aluminium smelting results in high Al and sulphur  deposition in the study area and therefore further studies should be carried out  taking into account potentially adverse effects of these compounds onhuman and ecosystem health.","palabras_clave":"PATAGONIA|ALUMINIUM|PHYSIOLOGICAL STATUS|EUCALYPTUS|POPULUS|PINUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":69446,"idioma_id":5,"titulo":"Biología de especies australes: Prosopis argentina Burkart ( Fabaceae , Mimosoideae )","resumen":"En este trabajo se realiza una revisión bibliográfica de la biología de  Prosopis argentina, especie dominante de los médanos y dunas en las   zonas áridas de Argentina, a partir de trabajos clásicos e   investigaciones recientes. Se abordan afinidades filogenéticas de la especie, su distribución geográfica, el hábitat, crecimiento y   comunidades en las que se desarrolla, la morfología, fenología, interacciones biológicas, ecofisiología, los usos etnobotánicos y sus   potenciales aprovechamiento. A pesar de constituir un endemismo de la zona árida argentina, P. argentina ha sido poco estudiada hasta el momento, por lo que la información resulta ser escasa.","palabras_clave":"ADAPTACION|ALGARROBO DEL GUANACO|ECOFISIOLOGÍA|MONTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":70363,"idioma_id":5,"titulo":"El desarrollo de la biotecnología y las vinculaciones público-privadas,  una discusión de la literatura orientada al caso argentino","resumen":"La inversión que realiza la Argentina en biotecnología ha crecido en el último tiempo pero todavía quedamuy relegada en la perspectiva internacional. Hay alrededor de 90 empresas que utilizan aplicaciones biotecnológicas.Se trata en general de empresas innovadoras y dinámicas cuyas exportaciones han crecido enel último tiempo pero en promedio su aporte al producto nacional es bajo y sólo una minoría ha conseguidoinnovación para el mercado internacional. Existen a su vez alrededor de 50 centros públicos de investigación(CPI) en biotecnología que dominan una mayor cantidad y diversidad de técnicas biotecnológicas queel sector privado, invierten más recursos y tienen personal más capacitado. La política pública ha sido favorableal desarrollo de esta tecnología y ha promovido la inversión privada y las alianzas público-privadas.En el nivel global, el desarrollo de la biotecnología depende del avance científico de una multiplicidad de disciplinasque tienen a la investigación pública como principal referente. Por tanto, el sector privado ha necesitadoestablecer vinculaciones con CPI fundamentalmente mediante la concesión amplia de licencias y lacreación de empresas por parte de científicos. Si bien esas modalidades han sido señaladas como las másapropiadas para industrias que se apoyan fuertemente en el conocimiento científico, como sucede con labiotecnología, también estas modalidades son las que conllevan mayores riesgos asociados con la privatizacióndel conocimiento público (Arza, 2010).Dada la brecha en los recursos invertidos en relación con los líderes, a los actores del país les resulta difícilcompetir globalmente. Por lo tanto, se plantea la necesidad de aprovechar mejor los recursos disponiblesy, según la experiencia internacional y las características del sector, deben evaluarse las ventajas y desventajasde intensificar las vinculaciones público-privadas. La producción de herramientas biotecnológicastiene un potencial estratégico en la generación de nuevas investigaciones aguas abajo y los productos biotecnológicostienen a su vez un amplio potencial para resolver problemas fundamentales en países en desarrollo,relacionados con la alimentación y la salud. La política pública en ciencia y tecnología (CyT) tiene eldesafío de mediar las tensiones que podrían existir entre los intereses privados y la necesidad de asegurarque el conocimiento incipiente que se ha desarrollado, principalmente dentro de los CPI, se mantenga en eldomino público de manera de asegurar que la investigación en el área continúe profundizándose y que lasaplicaciones que se persigan tengan amplio impacto social. Para esto es necesario democratizar tanto la discusiónsobre la direccionalidad del cambio tecnológico, como la negociación de una agenda en CyT.","palabras_clave":"BIOTECNOLOGIA|VINCULACIONES|UNIVERSIDAD|EMPRESA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":70809,"idioma_id":4,"titulo":"Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability","resumen":"Human aquaporin-8 (AQP8) channels facilitate the diffusional transport of H2O2 across membranes. Since AQP8is expressed in hepatic inner mitochondrial membranes, we studied whether mitochondrial AQP8 (mtAQP8)knockdown in human hepatoma HepG2 cells impairs mitochondrial H2O2 release, which may lead to organelledysfunction and cell death. We confirmed AQP8 expression in HepG2 inner mitochondrial membranes andfound that 72 h after cell transfection with siRNAs targeting two different regions of the human AQP8molecule,mtAQP8 protein specifically decreased by around 60% (pb0.05). Studies in isolated mtAQP8-knockdown mitochondriashowed that H2O2 release, assessed by Amplex Red, was reduced by about 45% (pb0.05), an effectnot observed in digitonin-permeabilized mitochondria. mtAQP8-knockdown cells showed an increase in mitochondrialROS, assessed by dichlorodihydrofluorescein diacetate (+120%, pb0.05) and loss of mitochondrialmembrane potential (&#8722;80%, pb0.05), assessed by tetramethylrhodamine-coupled quantitative fluorescence microscopy.The mitochondria-targeted antioxidant MitoTempol prevented ROS accumulation and dissipation ofmitochondrial membrane potential. Cyclosporin A, a mitochondrial permeability transition pore blocker, alsoabolished the mtAQP8 knockdown-induced mitochondrial depolarization. Besides, the loss of viability inmtAQP8 knockdown cells verified by MTT assay, LDH leakage, and trypan blue exclusion test could be preventedby cyclosporin A. Our data on human hepatoma HepG2 cells suggest that mtAQP8 facilitatesmitochondrial H2O2release and that its defective expression causes ROS-inducedmitochondrial depolarization via the mitochondrialpermeability transition mechanism, and cell death.","palabras_clave":"Mitochondria|Aquaporin-8|Hydrogen peroxide|HepG2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":70822,"idioma_id":5,"titulo":"Décimo Noveno Informe Semestral sobre Política Exterior del gobierno argentino  (Marzo a Septiembre de 2013)","resumen":"Alli se detallan los principales hechos de la Politica Exterior Argentina en el periodo de Septiembre de 2011 a Marzo de 2012","palabras_clave":"Relaciones|Internacionales|Política|Exterior"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71048,"idioma_id":4,"titulo":"Calorimetric characterization of Portland limestone cement produced by intergrinding","resumen":"The calorimetric technique provides continuous, direct, and general measurements of the course of coexisting reactions and their interactions during hydration of blended cement at early age. In this article, this technique is used to analyze the influence of compositional and process variables on the early age hydration of Portland limestone cements (PLC) made by intergrinding in a full size-cement plant. Eight cements, the vertices of 23 factorial design, were made with a limestone filler content (LF) of 0 and 24%, a gypsum content (GC) of 2.5, and 5.0%; and a fineness, measured as that fraction retained on a 45 mm sieve (R45), of 5 and 18%, to study their effects on the heat released. In addition, a PLC with a composition nearly to the center point of 23 designs was analyzed. Measurements were performed on cement pastes (w\/cm = 0.4) using a semiadiabatic differential calorimeter operating at 20 °C during 48 h. At different time, the heat released was determined and it was modeled using a linear mathematical model including the three variables (LF, R45, CG) and their interactions. The significance of the model, the variables and the interactions was judged using the analysis of variance. Results of model show that heat released is reduced by LF due to physically dilution phenomenon, which is directly proportional to LF content. The R45 exerts its major influence during the development of second peak (12-21 h) but later its effect declines to null contribution. GC retards and attenuates the hydration reactions moderately until 30 h, and then its increase contributes to Qt due to the formation of ettringite and its transformation. The only significant interaction was LF with R45 during the second peak development. Results present good correlation with the isolate measurement of compressive strength at 12, 24, and 48 h.","palabras_clave":"Limestone filller|heat released |Particle size |gypsum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71187,"idioma_id":4,"titulo":"EFFECT OF INCREASING DOSES OF PROANTHOCYANIDIN EXTRACTED FROM Ligaria cuneifolia ON BLOOD FLUIDITY IN RATS FED CHOLESTEROL-ENRICHED DIET","resumen":"Ligaria Cuneifolia (Lc) is an argentine hemiparasitic plant used in folk medicine for decrease of blood fluidity diminishing cholesterol(Co). Our aim was analyzes the effect of increasing doses of the PLcextract on the blood fl uidity of rats fed a diet enriched in Co. Adultmale Wistar rats (n = 24) were fed for 28 days with ?standard diet ?adding with Co (97% purity) 8 g \/ kg of diet and 28% corn oil (wt \/wt of diet). The group C (Control, n = 6) received saline and groupT (Treated) received the PLc extract, both groups in an ip injectionevery 24 hours, 3 consecutive days. The doses used were 1.5 mg\/100g body weight (BW) (T1, 5) (n = 6), 3 mg\/100 g PC (T3) (n = 6) and6 mg\/100 g PC (T6) (n = 6). The day of the experiment, 24 hours afterthe last injection, the animals were anesthetized by ip with sodium pentobarbital (50 mg \/ kg BW); the blood was obtained by cardiacpuncture. Total Co (mg%): C: 108.54±2.21; T1,5: 71.56±3.64*;T3: 61.18±3.30*; T6: 67.66±1.17*; CoLDL (mg%): C: 27.76±1.54;T1,5: 13.59±1.08*; T3: 16.13±1.33*; T6: 18.00±0.39*; CoHDL(mg%): C: 25.00±0.74; T1,5: 22.10±2.37*; T3: 15.57±0.60*; T6:18.75±0.95* (*p<0.05 vs C); relative blood viscosity standardized at a hematocrit of 45%, VSre: C: 5.55 ±0.26, T1,5: 6.26±0.39 (ns vsC); T3: 4.92±0.27 (ns vs C) T6: 7.05± 0.46 (ns vs C); rigidity index,RI: C: 5.86±0.24, T1,5: 6.93±0.44 (ns vs C), T3: 6.06±0.17 (ns vsC), T6: 6.79±0.73 (ns vs C). The treatment with increasing dosesof PLc decreases levels of total Co and both CoHDL and CoLDL,without to cause alterations in the fl uidity of blood.","palabras_clave":"INCREASING DOSES|PROANTOCYANIDIN|LIGARIA CUNEIFOLIA|BLOOD FLUIDITY|DIETS |HYPERCHOLESTEROLEMIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71521,"idioma_id":4,"titulo":"Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy","resumen":"BACKGROUND:  Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimately recurs. In this work we questioned whether the synthetic steroid mifepristone, which as monotherapy inhibits the growth of ovarian cancer cells, is capable of preventing repopulation of ovarian cancer cells if given after a round of lethal cisplatin-paclitaxel combination treatment.  METHODS:  We established an in vitro approach wherein ovarian cancer cells with various sensitivities to cisplatin or paclitaxel were exposed to a round of lethal doses of cisplatin for 1&#8201;h plus paclitaxel for 3&#8201;h. Thereafter, cells were maintained in media with or without mifepristone, and short- and long-term cytotoxicity was assessed.  RESULTS:  Four days after treatment the lethality of cisplatin-paclitaxel was evidenced by reduced number of cells, increased hypodiploid DNA content, morphological features of apoptosis, DNA fragmentation, and cleavage of caspase-3, and of its downstream substrate PARP. Short-term presence of mifepristone either enhanced or did not modify such acute lethality. Seven days after receiving cisplatin-paclitaxel, cultures showed signs of relapse with escaping colonies that repopulated the plate in a time-dependent manner. Conversely, cultures exposed to cisplatin-paclitaxel followed by mifepristone not only did not display signs of repopulation following initial chemotherapy, but they also had their clonogenic capacity drastically reduced when compared to cells repopulating after cisplatin-paclitaxel.  CONCLUSIONS:  Cytostatic concentrations of mifepristone after exposure to lethal doses of cisplatin and paclitaxel in combination blocks repopulation of remnant cells surviving and escaping the cytotoxic drugs.","palabras_clave":"Mifepristone|cancer de ovario|apoptosis|ciclo celular"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71700,"idioma_id":4,"titulo":"Characterization of a Root-Knot Nematode Population of Meloidogyne arenaria from Tupungato (Mendoza, Argentina)","resumen":"Abstract: Root-knot nematodes (Meloidogyne spp.) are polyphagous plant parasites of global importance. Successful host infection  depends on the particular interaction between a specific nematode species and race and a specific plant species and cultivar. Accurate  diagnosis of nematode species is relevant to effective agricultural management; and benefits further from understanding the  variability within a single nematode species. Here, we described a population of M. arenaria race 2 from Mendoza (Argentina). This  study represents the first morphometric, morphological, biochemical, reproductive, molecular, and host range characterization of  a root-knot nematode species from Argentina. Even after gathering morphological and morphometric data of this population and  partially sequencing its rRNA, an unequivocal taxonomic assignment could not be achieved. The most decisive data was provided by  esterase phenotyping and molecular methods using SCARs. These results highlight the importance of taking a multidimensional  approach for Meloidogyne spp. diagnosis. This study contributes to the understanding of the variability of morphological, reproductive  and molecular traits of M. arenaria, and provides data on the identification of root-knot nematodes on tomato cultivars from  Argentina.","palabras_clave":"MELOIDOGYNE ARENARIA|MOLECULAR TAXONOMY|MORPHOLOGY|ROOT-KNOT NEMATODE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71842,"idioma_id":4,"titulo":"Halloysite in Argentinian deposits. Origin and textural constraints","resumen":"In Argentina, the only halloysite deposits found so far are located in the southwest of the province of Rio Negro. The areas are named Mamil Choique and Buitrera, separated 50 km in W-E direction. The deposits are located in pyroclastic rocks, rhyolitic tuffs and ignimbrites.  The aim of this paper is to determine the origin of the alteration, if there is a relationship between the process in Mamil Choique and Buitrera and which are the factors that controlled the halloysite formation. The work was based on field work, mineralogical and geochemical studies, form and distribution of the alteration.  Fresh as well as altered rocks were collected. The first was studied by petrographic and chemical methods.  In altered samples, clay mineralogy was determined by XRD and textures by SEM and TEM. Chemical analyses on fresh and altered samples were used to characterize the alteration process and the rock composition.  It was concluded that halloysite has been formed by weathering in a time range from Middle Eocene to Middle Oligocene and extended along 50 km in W-E direction, independently of the source rock. Particle morphology depends on the original texture of the rock, spheroidal halloysite is related to rocks with low porosity and tubular particles are related to rocks with open spaces.","palabras_clave":"halloysite|Patagonia|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71947,"idioma_id":4,"titulo":"Reproductive traits of the small Patagonian octopus Octopus tehuelchus","resumen":"This study evaluated the reproductive features of Octopus tehuelchus in three coastal environments of San Matías Gulf (Patagonia). Monthly samples of O. tehuelchus were used to estimate size at maturity, compare seasonal changes in oocyte size frequency distributions between  sites as well as oocyte number and size between female maturity stage and sites. Females in Islote Lobos had a smaller size at maturity than females in San Antonio Bay and El Fuerte, probably as a consequence of a generally smaller body size. Males in San Antonio Bay were smaller at maturity than females. O. tehuelchus is a simultaneous terminal spawner. Fecundity (expressed as number of vitellogenic oocytes in ovary) was lower in Islote Lobos, and an increase in oocyte number in relation to female total weight was found. Females in San Antonio Bay had the largest oocytes, which may indicate higher energy reserves for the embryo and therefore higher juvenile survival. There was a close relationship between reproduction, growth and condition, represented as size at maturity, number and size of vitellogenic oocytes and period of  maturity and spawning. Given the local variation in some reproductive features of O. tehuelchus, studies should focus on the environmental factors, which bring about this variation, and on how it affects the dynamics of local populations.","palabras_clave":"Reproductive pattern |Fecundity|Octopus tehuelchus|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":71999,"idioma_id":4,"titulo":"PPARg ligand treatment inhibits cardiac inflammatory mediators in both acute and chronic mouse models of Trypanosoma cruzi infection","resumen":"Trypanosoma cruzi (T. cruzi), the etiological agent of Chagas´ disease, causes cardiac alterations in the host. Although the main clinical manifestations arise during the chronic stage, the mechanisms leading to heart damage develop early during infection. In fact, an intense inflammatory response is observed from acute stage of infection. Recently, peroxisome proliferator-activated receptors (PPARs) have attracted research interest due to their participation in the modulation of inflammation. In this work we addressed the role of 15-Deoxy-&#8710;12,14 PGJ2 (15dPGJ2), a PPARã natural ligand in the regulation of inflammatory mediators, in acute and chronic experimental mouse models of Chagas´ disease with the RA and K98 T. cruzi strains, respectively. This work demonstrates that 15dPGJ2 treatment inhibits the expression and activity of inducible nitric oxide synthase (NOS2) as well as TNF-á and IL-6 mRNA levels. Also, expression and activity of metalloproteinases 2 (MMP-2) and 9 (MMP9) were inhibited by 15dPGJ2. Moreover GW9662, a specific PPARã antagonist, revealed the participation of other signaling pathways since, in GW9662 presence, 15dPJG2 had a partial effect on the inhibition of inflammatory parameters in the acute model of infection. Accordingly, NF-êB activation was demonstrated, assessing p65 nuclear translocation in the hearts of infected mice with both T. cruzi strains. Such effect was inhibited after 15dPGJ2 treatment. Our findings support the concept that in vivo PPARã and NF-êB pathways are implicated in the inhibitory effects of 15dPGJ2 on inflammatory mediators at different times depending on whether the infection is caused by the lethal or non-lethal T. cruzi strain.","palabras_clave":"PPARg|Trypanosoma cruzi|Heart|Inflammation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72095,"idioma_id":5,"titulo":"Identificación de zonas de manejo sitio-específico a partir de la combinación de variables de suelo","resumen":"El manejo sitio-específico demanda la identificación de  sub-regiones homogéneas, o zonas de manejo (ZM), dentro  del espacio productivo. Sin embargo, definir ZM suele  ser complejo debido a que la variabilidad espacial del  suelo puede depender de varias variables. La zonificación  o delimitación de ZM puede realizarse utilizando una variable  de suelo a la vez o considerando varias variables simultáneamente.  Entre los métodos de análisis multivariado,  difundido para la zonificación, se encuentra el análisis  de conglomerados fuzzy k-means (KM) y el análisis de  componentes principales (PCA). No obstante, como otros  métodos multivariados, éstos no han sido desarrollados  específicamente para datos georreferenciados. Una nueva  versión del PCA, conocido como MULTISPATI-PCA  (PCAe), permite contemplar la autocorrelación espacial  entre datos de variables regionalizadas. El objetivo de este  estudio fue proponer una nueva estrategia de análisis para  la identificación de ZM, combinando la aplicación KM y  PCAe sobre datos de múltiples variables de suelo. La capacidad  del método propuesto se evaluó en base a la comparación  de los rendimientos promedios alcanzados en  cada zona delimitada, tanto para la combinación de KM  con PCA, la aplicación tradicional de KM sobre las variables  originales y la nueva propuesta KM-PCAe. Los resultados  mostraron que KM-PCAe fue el único método que  permitió distinguir zonas estadísticamente diferentes en  cuanto al potencial productivo. Se concluye que la combinación  propuesta constituye una herramienta importante  para el mapeo de la variabilidad espacial y la identificación  de ZM a partir de datos georreferenciados.","palabras_clave":"Agricultura de Precisión|Zonas de manejo|Cluster fuzzy k-means|PCA|MULTISPATI_PCA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72209,"idioma_id":5,"titulo":"Sistematización de una experiencia de educación ambiental en la formación docente continua: representaciones, ambiente y análisis colaborativo","resumen":"Este trabajo presenta una descripción y primer análisis de algunos aspectos de la implementación de una propuesta de formación docente en servicio relacionados con la educación ambiental. Dicha propuesta formativa general contempló tres ejes de trabajo simultáneos: 1)Caracterización de prácticas de enseñanza actuales en ciencias naturales; 2) Elaboración, implementación y análisis de propuestas áulicas innovadoras; y 3) Proceso de formación docente en servicio basado en la reflexión sobre la práctica. Socializamos aquí las categorías resultantes del análisis de producciones de participantes en el Taller de Ambiente y la sistematización de la propuesta de formación, como un aporte a la constitución del campo de la Educación Ambiental. El análisis meta-reflexivo sobre las concepciones de ambiente aportó a la caracterización y revisión de concepciones vinculadas a la enseñanza de las ciencias naturales. Además, el proceso de reflexión colaborativa fue un insumo para la formación conjunta, brindando herramientas a los docentes que facilitaron la objetivación y caracterización de la propia mirada como camino a la construcción de propuestas de enseñanza alternativas críticas. Finalmente, consideramos que contribuyó a la construcción de marcos que guiarían la elaboración, implementación y análisis de propuestas áulicas innovadoras.","palabras_clave":"FORMACIÓN DOCENTE CONTINUA|REPRESENTACIONES|AMBIENTE|ANÁLISIS COLABORATIVO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72380,"idioma_id":4,"titulo":"High-level expression of Falcipain-2 in Escherichia coli by codon optimization and auto-induction.","resumen":"Falcipain-2, the major cysteine hemoglobinase from the human malaria parasite Plasmodium falciparum, is critical for parasite development and is considered a promising chemotherapeutic target. In order to facilitate the high-throughput screening of Falcipain-2 inhibitors from natural sources, we developed an economic and highly-productive overexpression system in Escherichia coli using a codon-optimized proFalcipain-2 construct. Very high expression levels (35-55% of total host proteins) were observed when proFalcaipain-2 expression was induced with 1mM isopropyl-1-thio-B-D-galactopyranoside (IPTG) in several E. coli strains, with the highest level observed for BL21(DE3). A lower expression (~40% of total host proteins) was observed when BL21(DE3) was grown in ZYM-5052 auto-induction medium, containing 0.2% lactose as inducer. However, the culture grew to notably higher cellular density, increasing ~1.5 times the overall yield of the system when compared with conventional IPTG-induction. Although several conditions were modified to achieve the expression of soluble and active Falcipain-2, the enzyme was mainly obtained in the form of insoluble aggregates. After purification and refolding, ~50 mg of active enzyme were obtained per liter of culture at low cost using a regular incubator shaker, and recombinant Falcipain-2 exhibited structural and functional characteristics very similar to the natural counterpart. Due to its versatility and simplicity, this strategy can be straightforwardly adapted to other proteins from Plasmodium species or any other organism with an AT-rich genome.","palabras_clave":"FALCIPAIN-2|PLASMODIUM FALCIPARUM|SYNTHETIC GENE|CODON OPTIMIZATION|AUTO-INDUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72868,"idioma_id":4,"titulo":"Scale measuring fear of dental care","resumen":"The fear of pain is an obstacle that interferes with the patient dental visits. With the aim of preventing it, a fear exploring scale for dental visits and the strategies to decrease it were designed. The Likert Rating Scale was used; it was applied to 105 patients from ?Facultad de Odontología de la Universidad Nacional de Cuyo' in Mendoza city. The patients stated that they are afraid of the following: infection transmitted by the dentist, the dentist not wearing gloves (or not changing them), &nbsp;the consequences of poor hygiene; secondly, they are very scared of the break of a tooth, or a mistaken diagnosis. Most of the patients wish to be treated comprehensively, to be told about the procedures and to be aware of what they may feel. ","palabras_clave":"FEAR|RATING SCALE|DENTISTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72876,"idioma_id":5,"titulo":"Escala de medición del miedo a la atención dental","resumen":"El miedo al dolor constituye un obstáculo que interfiere la consulta dental del paciente y, con el objeto de prevenirlos, se diseña una escala de exploración del miedo a la consulta dental y de las estrategias deseables para disminuirlo. Se utilizó el Método de Escalonamiento de Likert y se aplicó a 105 pacientes en la Facultad de Odontología de la Universidad Nacional de Cuyo, Mendoza. Los pacientes responden que sienten mucho miedo a que el odontólogo pueda trasmitirles una infección, ser revisados sin guantes, o que no se los cambie, y a las consecuencias de la mala higiene. En segundo lugar tienen mucho miedo a que el odontólogo pueda tocar un nervio, que perfore excesivamente, que se quiebre una pieza dentaria o se equivoque en el diagnóstico. La mayoría desea ser tratada comprensivamente y que se le explique los procedimientos y anticipe lo que va a sentir.","palabras_clave":"ODONTOLOGÍA|PSICOLOGÍA|MIEDO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":72966,"idioma_id":5,"titulo":"Actividad antimicrobiana de películas comestibles elaboradas a base de proteínas del lactosuero y glicerol incorporadas con sales orgánicas","resumen":"El empleo de películas comestibles formuladas con compuestos antimicrobianos para recubrir alimentos es una forma de envasado activo. Mediante esta tecnología, se busca extender la vida útil de un producto alimenticio y disminuir la tasa de contaminación microbiana favoreciendo la seguridad de los consumidores. Los ácidos orgánicos y sus sales han sido utilizados ampliamente como aditivos alimenticios para controlar el desarrollo de patógenos y evitar la diseminación de enfermedades. En el presente trabajo, se evaluó el potencial antimicrobiano de películas comestibles elaboradas a base de proteínas del lactosuero (WPC) y glicerol (Gli) con la incorporación de sorbato de potasio (SP), benzoato de sodio (BS) y propionato de sodio (PS) frente a la cepa shigatoxigénica Escherichia coli O157:H7 ATCC 43895. La incorporación de las sales orgánicas en las películas ácidas de WPC\/Gli obtenidas a pH 5,2 se realizó en cuatro concentraciones: 0,25%, 0,50%, 0,75% y 1,0% p\/p. La actividad antimicrobiana se evaluó en medio agar Mueller-Hinton regulado a pH 5,2 a través de ensayos de difusión en agar y pruebas de barrera (cualitativa y cuantitativa). Además, se estudió la relación entre la capacidad antimicrobiana de las películas y la concentración de inóculo bacteriano (alto y bajo). El ensayo de difusión mostró que la incorporación de SP y BS a las películas comestibles de WPC\/Gli redujo o inhibió el crecimiento de E. coli, excepto cuando la concentración de SP fue 0,25%. Este efecto fue más notorio a medida que la concentración de sales orgánicas en las películas aumentó y más evidente a inóculo bajo del patógeno. No se observó inhibición alguna ante la incorporación de PS en las películas. Los resultados de las pruebas de barrera cualitativa revelaron que tanto el SP como el BS a concentraciones iguales o superiores a 0,50% presentan excelentes propiedades&nbsp; para prevenir la contaminación externa, no siendo efectiva la adición de PS a las concentraciones&nbsp; ensayadas. Los resultados de las pruebas de barrera cualitativa y cuantitativa fueron coherentes con los obtenidos en los ensayos de difusión en agar. En conclusión, la adición de SP y BS a&nbsp; películas comestibles ácidas de WPC\/Gli puede ser de suma utilidad para prevenir la&nbsp; contaminación post-proceso de los alimentos, demostrando un amplio potencial para su aplicación&nbsp; como recubrimiento activo en la industria alimentaria.","palabras_clave":"películas comestibles|proteínas del lactosuero|sales orgánicas|actividad antimicrobiana|enfermedades transmitidas por los alimentos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":73214,"idioma_id":5,"titulo":"Decisión multicriterial considerando costos ambientales para evaluar sistemas de labranza","resumen":"El objetivo general del presente trabajo es evaluar las prácticas de labranza desde un punto de vista integral, comparando la siembra directa  con la labranza convencional en función de diferentes criterios ambientales, económicos y sociales representativos de los atributos de la sustentabilidad.  Se persigue efectuar una contribución tendiente a hacer operativo el concepto de sustentabilidad en la administración socialmente responsable de la empresa rural, como consecuencia de perfeccionar su sistema de información integral para soporte del proceso decisorio. Asimismo, se  considera que podría apoyar la formulación de políticas públicas para el Desarrollo Sustentable del sector agropecuario, dado su relevante rol en la economía nacional, especialmente en regiones semiáridas y subhúmedas.","palabras_clave":"SISTEMAS DE LABRANZA|COSTOS AMBIENTALES|METODOS MULTICRITERIO|DESARROLLO SUSTENTABLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":73539,"idioma_id":4,"titulo":"A simple laboratory class using a Pseudomonas aeruginosa auxotroph to illustrate UV-mutagenic killing, DNA photorepair and mutagenic DNA repair","resumen":"A simple and cheap laboratory class is proposed to illustrate the lethal effect of UV radiation on bacteria andthe operation of different DNA repair mechanisms. The class is divided into two sessions, an initial 3-hourexperimental session and a second 2-hour analytical session. The experimental session involves two separateexperiments: one dedicated to illustrating the lethal effect of UV radiation and the protective effect of DNAphotorepair; the second to explore the operation of DNA repair mechanisms that prioritise survival but introducemutations. The procedure makes use of a Pseudomonas aeruginosa double auxotroph, which serves to detectUV-induced back-mutations to prototrophy. The proposed scheme is carried out by undergraduate students ofthe Bacterial Physiology and Genetics course, as part of our Biotechnology curriculum. We think that it willbe a valuable tool for microbiology students to increase their understanding of basic genetic concepts.","palabras_clave":"UV killing|UV mutagenesis|Photoreactivation|Mutagenic DNA repair"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":73617,"idioma_id":4,"titulo":"New improved strategy for the selection of cold adapted antagonist yeasts to control postharvest pear diseases","resumen":"Postharvest diseases cause considerable losses of harvested fruits   during transportation and storage. Many yeast species have been reported   as good antagonists against postharvest pear pathogens. In this work,   we used a novel selection strategy that involves the isolation of yeasts   from washing fluids, showing biocontrol activity against a regional Penicillium expansum   strain (primary screening), originally obtained from fruit wounds after   long time storage at &#8722;1\/0°C. About 26 isolates representative of the 11   yeast species identified in the 27 selected washing waters were chosen   to be evaluated in a secondary screening against a regional Botrytis cinerea strain on pear wounds. Among yeasts tested, 38% showed complete control of P. expansum, but only 15% reduced the decay incidence of B. cinerea   to 60-80% at &#8722;1\/0°C. These results reveal that some of the yeasts found   can be biological alternatives to fungicides in the control of P. expansum and B. cinerea   infections. Based on the data obtained, our strategy seems to be much   more effective than the previously reported methods in obtaining   successful biocontrol agents.","palabras_clave":"POSTHARVEST DISEASES|ANTAGONISTS YEASTS|PEARS|BIOCONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":73691,"idioma_id":4,"titulo":"Correlation between MVD and Two Prognostic Factors: Fuhrman Grade","resumen":"Introduction: Clear cell RCC is the most common type of RCC that occurs in adults and it has the worst prognosis among the common epithelial tumors of these organs. The CD34 is an endothelial antigen that has been used to highlight the microvessel density (MVD) as a direct marker of neoangiogenesis degree. Objective: To establish the correlation between CD34 and other prognostic factors like Fuhrman nuclear degree and tumoral size. Material and methods: Tumour samples from 17 patients with histopathology diagnosis of clear cell RCC were examined by immunohistochemical staining for CD34. The CD34 expression was analyzed by Anova and Student Newman Multiple Comparison Test and Tuckey like post test, and finally we used a Spearman Correlation to compare with the others prognostic factors analysed and Kaplan Meier survival analysis for the disease free survival of the patients. Results and conclusion: There is a negative correlation between the MVD and the Fuhrman nuclear grade, whereas R = -0,46; and p < 0,05 and there is a positive correlation between the MVD and the maximum tumoral diameter, whereas R = 0,47 and p < 0,05. In conclusion, we found that a high MVD is related with a low Fuhrman nuclear grade and a high tumoral size. The possible significance of this study can be that in fact we need more than one parameter to predict the biological behavior of the clear cell CCR.","palabras_clave":"Kidney;|Clear cell CCR|MVD|Tumoral size"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":73843,"idioma_id":5,"titulo":"La cuenca hidrográfica como unidad de evaluación de la geodiversidad. Parque Provincial Ernesto Tornquist, Buenos Aires","resumen":"La conservación de la Naturaleza de manera integral se realiza cuando se protege tanto la Biodiversidad como la Geodiversidad. Este último término incluye al conjunto de elementos abióticos de valor científico, cultural, educativo y\/o recreativo. Entonces, el concepto de Geodiversidad nace como una herramienta aplicada a la gestión de espacios protegidos. El Parque Provincial Ernesto Tornquist (PPET) se localiza en el noreste del partido de Tornquist, provincia de Buenos Aires. Una de las principales causas de su creación fue la conservación del paisaje natural y especies endémicas en el Sistema de Ventania. Incluye el Cerro de la Ventana (Monumento Natural) y especies vegetales pertenecientes al Distrito Austral argentino. Dentro del área protegida se encuentran las nacientes de tres cuencas hídricas de gran importancia para la región del suroeste bonaerense. El PPET se constituyó en un área de interés turístico-ambiental de gran relevancia provincial. La reserva cuenta con un plan de manejo desde 1997 en el que se desarrolla ampliamente la necesidad de conservación y manejo de la Biodiversidad, sin embargo el concepto de Geodiversidad no es abordado en detalle. Por ello, el objetivo del presente trabajo es valorar la Geodiversidad en el Parque Provincial Ernesto Tornquist. Se siguió la propuesta de Serrano Cañadas y Ruiz Flaño (2007) y se utilizó la cuenca hidrográfica como unidad de análisis. Se establecieron tres unidades hidrográficas dentro de los límites del área protegida. Para cada unidad se calculó el índice de Geodiversidad (Gd) teniendo en cuenta la variabilidad de elementos físicos que la componen, la superficie y la rugosidad. La cuenca que presenta mayor valor de Geodiversidad es la del río Sauce Corto (Gd = 30,93). Para la cuenca del arroyo de la Ventana y el río Sauce Grande se obtuvieron valores de Gd = 15,36&nbsp; y 8,14 respectivamente.","palabras_clave":"CUENCA HIDROGRÁFICA|GEODIVERSIDAD|AREA PROTEGIDA|PARQUE PROVINCIAL ERNESTO TORNQUIST|SISTEMA DE VENTANIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74100,"idioma_id":5,"titulo":"Las situaciones de alfabetización temprana en el hogar de dos grupos sociales de Argentina","resumen":"En el marco de las perspectivas socioculturales actuales  (Nelson, 2010) y en las líneas de investigación de  alfabetización temprana y familiar (Hannon & Bird, 2004), se  analizan 296 situaciones de alfabetización registradas en  hogares de 20 niños de 4 años de poblaciones urbano marginadas  y 20 niños de sectores medios. Empleando un procedimiento  cualitativo (Strauss & Corbin, 1991) se analizaron  comparativamente las situaciones registradas en ambos grupos  atendiendo al tipo y a la estructura de la situación y a la  interacción entre los participantes. Se identificaron  diferencias en el tipo y la cantidad de situaciones en las que  participaron los niños de ambos grupos. No se observaron  diferencias en el interés de los niños por la lectura y la  escritura.","palabras_clave":"ALFABETIZACIÓN TEMPRANA|ALFABETIZACIÓN FAMILIAR|DIFERENTES GRUPOS SOCIALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74206,"idioma_id":5,"titulo":"Hidrogenación selectiva de 1-heptino con catalizadores de Ni, Pd y W soportados en &#61543;-alúmina","resumen":"La hidrogenación selectiva de alquinos tiene gran importancia desde el punto de  vista académico e industrial. Industrias tales como la petroquímica, farmacéutica y  agroquímica usan estos compuestos como materia prima. Los catalizadores comerciales  típicos para este tipo de reacciones contienen metales tales como paladio. Un gran  desafío resulta encontrar catalizadores más económicos que sean activos y selectivos  para ser usados en la producción de alquenos vía la hidrogenación parcial de alquinos.  Es por ello que el principal objetivo de este trabajo es preparar catalizadores  monometálicos de baja carga de níquel (Ni), paladio (Pd) y tungsteno (W) soportados  sobre &#947;-alúmina, para ser evaluados en la hidrogenación parcial de 1-heptino, un alquino  de elevada masa molecular, bajo moderadas condiciones de operación. Los catalizadores  se caracterizan por Espectroscopia de Emisión Atómica (ICP), Difracción de Rayos X  (DRX), Reducción a Temperatura Programada (RTP) y Quimisorción de Hidrógeno, de  forma tal de identificar las especies activas. Para todos los catalizadores, se comparan la  conversión total de alquino y selectividad a 1-hepteno (producto deseado) a distintas  temperaturas, de forma tal de determinar la óptima temperatura de trabajo","palabras_clave":"HIDROGENACION SELECTIVA|METALES SOPORTADOS |1-HEPTINO|ALQUINOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74260,"idioma_id":4,"titulo":"Structural analysis of B-cell epitopes in antibody:protein complexes","resumen":"The binding of antigens to antibodies is one of the key events in an immune response against foreign molecules and is a critical element of several biomedical applications including vaccines and immunotherapeutics. For development of such applications, the identification of antibody binding sites (B-cell epitopes) is essential. However experimental epitope mapping is highly cost-intensive and computer-aided methods do in general have moderate performance. One major reason for this moderate performance is an incomplete understanding of what characterizes an epitope. To fill this gap, we here developed a novel framework for comparing and superimposing B-cell epitopes and applied it on a dataset of 107 non-similar antigen:antibody structures extracted from the PDB database. With the presented framework, we were able to describe the general B-cell epitope as a flat, oblong, oval shaped volume consisting of predominantly hydrophobic amino acids in the center flanked by charged residues. The average epitope was found to be made up of &#8764;15 residues with one linear stretch of 5 or more residues constituting more than half of the epitope size. Furthermore, the epitope area is predominantly constrained to a plane above the antibody tip, in which the epitope is orientated in a -30° to 60° angle relative to the light to heavy chain antibody direction. Contrary to previously findings, we did not find a significant deviation between the amino acid composition in epitopes and the composition of equally exposed parts of the antigen surface. Our results, in combination with previously findings, give a detailed picture of the B-cell epitope that may be used in development of improved B-cell prediction methods.","palabras_clave":"B cell epitope|Antigen|Immuno informatics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74520,"idioma_id":5,"titulo":"Pulmonary Hydatidosis","resumen":"paciente con hidatidosis pulmonar","palabras_clave":"Hidatidosis|Pulmonar|Tratamiento|Clinico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74641,"idioma_id":5,"titulo":"Análisis teórico y empírico de los seguros ambientales en Argentina","resumen":"El trabajo presenta, desde un abordaje teórico, el desarrollo de un modelo económico de seguro ambiental con transferencia de riesgos y algunas extensiones, considerando asimetrías de información. Desde el punto de vista empírico, se analiza el marco regulatorio vigente en Argentina y se describe el mercado de seguros ambientales. Finalmente, se comparan las características que emergen del modelo teórico respecto de aquellas observadas empíricamente. Los resultados sugieren que existe similitud en algunas nociones, como el incentivo al agente o la señalización, mientras que en otras se presentan diferencias sustanciales, como la transferencia de riesgo y la determinación del monto asegurable.  ISSN 1850-6933 (IMPRESO) | ISSN 1853-1350 (DIGITAL)","palabras_clave":"SEGURO AMBIENTAL|ASIMESTRÍAS DE INFORMACIÓN|REGULACIÓN|INCENTIVOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74765,"idioma_id":5,"titulo":"Educándonos en la inclusión de cara a la pobreza. Escuela y Universidad construyendo juntas","resumen":"El presente proyecto busca atender las problemáticas diagnosticadas en el Barrio Nuevo Golf de la ciudad de Mar del Plata, y así promover el cumplimiento de los Derechos Universales de los Niños.   Nuestro propósito es erradicar la mayor cantidad de viviendas en riesgo, atender la falta de una alimentación adecuada, reconocer y valorizar los recursos territoriales disponibles en el entorno inmediato y atender las problemáticas ambientales asociadas a la pobreza y que tienen implicancia directa en la salud y educación.  La autoconstrucción colectiva, a partir de estrategias innovadoras y amigables con el medio ambiente. Asimismo, acciones de impacto directo sobre la salud humana, a través del trabajo con Zoonosis, quienes establecen un plan prevención de enfermedades transmitidas por las mascotas; la autoproducción de alimentos, en el marco del Programa Pro huerta del INTA y el asesoramiento en compostaje, ya que el barrio no cuenta con  recolección de residuos domiciliarios, son algunas de las acciones tendientes al logro de los objetivos.","palabras_clave":"Autoconstrucción Comunitaria|Derechos de Niño|Universidad -Escuela"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74825,"idioma_id":5,"titulo":"Estilo y tiempo. Un estudio sobre la cronología del estilo cerámico Famabalasto Negro Grabado del Noroeste Argentino mediante dataciones radiocarbónicas","resumen":"Considerando como punto de partida las diferentes hipótesis referidas a la temporalidad de la alfarería estilo Famabalasto Negro Grabado del Noroeste Argentino, se evalúan un total de cuarenta fechados radiocarbónicos en sitios de los valles Calchaquí, Hualfín y -principalmente- Yocavil con el propósito de ajustar la cronología de este particular estilo alfarero. El análisis contextual crítico propuesto considera los niveles de asociación entre la muestra orgánica fechada y el evento a datar y también los niveles de asociación entre el evento datado y el conjunto cerámico espacialmente vinculado, a la luz de la información disponible. A través del tratamiento estadístico de los datos radiocarbónicos con buen nivel de asociación a cerámicas de estilo Famabalasto Negro Grabado se propone ubicar el lapso de su producción a nivel regional hacia los inicios del siglo XIV y mediados del siglo XVI.","palabras_clave":"Cerámica Famabalasto Negro Grabado|fechados radiocarbónicos|cronología|Valle de Yocavil|Noroeste argentino"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74895,"idioma_id":5,"titulo":"PRINCIPALES DESARROLLOS Y ENFOQUES SOBRE ALIANZA Y RELACIÓN TERAPÉUTICA","resumen":"Existe un consenso general de que una parte importante del éxito de un tratamiento psicoterapéutico depende de la relación entre paciente y terapeuta. Los diferentes modelospsicoterapéuticos conceptualizan la relación terapéutica de diversas maneras; en particular, dicho conceptopresenta importantes diferencias entre la perspectiva psicoanalítica y la cognitivo-conductual. En el presente artículo, se intenta reseñar dichas diferencias en la literatura pertinente proponiendo, de este modo, una actualización del estado de conocimiento sobre el tema.En función de ello, se mencionan los principales antecedentes históricos del concepto de relación terapéutica y las líneas clásicas y actuales de investigación sobre el mismo. Para ello se realizó una revisión bibliográfica de los trabajos disponibles en las bases de datos EBSCO y Jstore. Las palabras clave utilizadas son: Relación Terapéutica, Alianza Terapéutica, Psicoanálisis, TCC. Se tomaron en cuenta principalmente los trabajos realizados apartir de 1990.","palabras_clave":"alianza terapéutica|psicoanálisis|cognitivo-conductual"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":74941,"idioma_id":5,"titulo":"Evaluación de Aceros Inoxidables Duplex para La Construcción de un Digestor","resumen":"Se estudia la posibilidad de fabricación de un digestor para una planta de pulpado Kraft, evaluando el comportamiento respecto a la corrosión de aceros inoxidables. Los aceros inoxidables dúplex empleados como electrodos de trabajo fueron: LDX 2101, 2205 y SAF 2304, en tres zonas, seno de la aleación, cordón de soldadura y zona afectada por el calor (zac). Se aplicaron Normas ASTM. Se obtuvieron también resultados proporcionados por la técnica de Espectroscopia de Impedancia Electroquímica, además de observaciones ópticas. Las medidas se realizaron en los medios especificados por las normas y en licor blanco, solución de 90 g\/l NaOH, 40 g\/l SNa2 y 20 g\/l Na2CO3, pH 14, a T= 90-100 ºC. Las aleaciones sufrieron ataque tipo rendija y picadura, o solamente picadura según la agresividad del medio. La susceptibilidad al ataque intergranular fue diferente según la aleación y la zona sometida a estudio. Se concluye que el acero inoxidable duplex 2205 es menos susceptible a la corrosión localizada.","palabras_clave":"digestor|aceros inoxidables duplex"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75343,"idioma_id":5,"titulo":"Niños, niñas y Adolescentes con sufrimiento psicosocial en la Ciudad de Buenos Aires: Historia de la constitución, inicio y fundamentos de un programa de salud mental comunitaria","resumen":"El siguiente escrito se propone transmitir el contexto de surgimiento, el marco teórico y los fundamentos del Programa de Atención Comunitaria de Niños, Niñas y Adolescentes con Trastornos Mentales Severos (PAC) perteneciente a la Dirección de Salud Mental de la Ciudad de Buenos Aires, creado en el año 2006.   Dicho programa tuvo como objetivo central aliviar el sufrimiento de niños, niñas y adolescentes y de sus familias en situaciones de significativa vulnerabilidad psicosocial.    Se propuso desde sus orígenes dar respuesta  a las necesidades de los niños, niñas y adolescentes a través de la implementación de un dispositivo que ampliara las alternativas de atención de niños y niñas con trastornos mentales severos, y ofreciera los cuidados integrales adecuados dese una perspectiva de derechos y de género, enmarcados en la legislación vigente.  Para ello se explicitan y desarrollan los principios rectores de esta práctica en salud mental comunitaria que han sido la guía y el soporte de la experiencia.","palabras_clave":"niños|Programa|Atención Comunitaria|Salud Mental"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75348,"idioma_id":5,"titulo":"Relato de una experiencia en salud mental comunitaria: cuando de la niñez se trata","resumen":"Diversas investigaciones en sistemas y servicios de salud que llevamos a cabo en laCiudad de Buenos Aires un equipo de investigación formado por profesionales del Hospitalde Día Infantil ? La Cigarra? perteneciente al Centro de Salud Mental N°1 e investigadorespertenecientes a la Universidad de Buenos Aires en el marco de un Proyecto UBACyT consede en la Facultad de Psicología, evidenciaron que durante el período 1995-2005 hubo unaumento de las problemáticas psicosociales en la niñez, así como de las consultas de niños,niñas y adolescentes con trastornos mentales severos.Esta nueva demanda evidenció la insuficiencia de servicios para brindar los cuidados desalud necesarios y las importantes barreras en la accesibilidad a los mismos, dada lacomplejidad del padecimiento que presentaban los niños, niñas y adolescentes consufrimiento psicosocial. Tales barreras se expresaban ?desde el sistema de salud- en lainsuficiente cantidad de equipos que trabajaran de manera interdisciplinaria, en una deficitariacapacitación dentro de los equipos, en la escasa detección temprana de trastornos mentalesseveros, e inclusive en los tiempos de tratamiento que el propio sector salud estipula para darrespuesta a la problemática mental severa. A estas situaciones se agregaba además ladificultad que experimentaban los equipos para la implementación de estrategias deintegración en la comunidad de estos niños\/as. Por otra parte, entre 1993 y 2005 seduplicaron las internaciones psiquiátricas de niños, niñas y adolescentes, y se prolongaronlos períodos de internación dada la ausencia de dispositivos terapéuticos territorializados endonde pudieran continuar los tratamientos, y de lugares de alojamiento subjetivantes, noasilares, cuando no contaban con familia.El diagnóstico de situación al que habíamos arribado ?tras varias investigaciones- poníaen relieve por un lado la escasez de respuestas sanitarias estatales a la totalidad de la demandaque se presentaba y por otro un lesionante proceso de inequidad que estaba dejandodesamparados a niños\/as y adolescentes con profundas necesidades de cuidado integral. Estonos interpelaba como efectores del sistema de salud y siendo entonces parte activa delproceso salud-enfermedad-cuidado nos situaba ante la necesidad de construir otros puentes enla accesibilidad a los cuidados de salud.En el marco de este escenario, la creación del Programa de Atención Comunitaria a niños ,niñas y adolescentes con trastornos mentales Severos - PAC (Resolución 1175 del año2007.Ministerio de Salud GCBA) fue iniciativa de un grupo interdisciplinario deprofesionales que a partir de las necesidades relevadas, lo diseñaron, lo consensuaron con laRed de Servicios de Salud Mental de Niños de la Dirección de Salud Mental y lo presentarona las autoridades logrando su inclusión en el organigrama del Ministerio de salud delGobierno de la Ciudad, colocando en agenda la problemática de la niñez con gravesufrimiento psíquico. De este modo, la creación de un programa partió de la detecciónconcreta de dificultades ubicables dentro del propio sistema de salud, la experiencia clínicasostenida en el sector público, relevamientos estadísticos diversos y la investigaciónacadémica de corte más analítico y cualitativo. Todo este camino que partió en una doble eimbricada articulación entre las condiciones singulares de cada niño\/a y las condiciones macrosociosanitarias hicieron posible el diseño de un programa como respuesta que representaba unmovimiento de transferencia de lo hallado al mismo sistema sanitario.","palabras_clave":"Salud mental|Comunitaria|Niñez|Programa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75379,"idioma_id":5,"titulo":"Reseña de Estéticas bastardas de José Amícola","resumen":"Tal como lo plantea Harold Bloom, el modelo de la historia literaria dominado por la ?ansiedad de las influencias? es el de una guerra entre padres e hijos que responde fundamentalmente a las descripciones freudianas de tal relación. José Amícola en su nuevo libro retoma las consideraciones genealógicas a la hora de pensar la historia literaria argentina e introduce la idea de ?bastardía? que permite pensar tanto las continuidades y los linajes como las ilegitimidades y transgresiones. Ya al abordar en textos anteriores el lugar de Puig en el campo literario argentino, Amícola afirmaba que el lugar predominante de Borges hizo que la literatura nacional tenga un ?aire de familia? que no es visible en otras literaturas del continente. En este nuevo libro Amícola apela a las metáforas de lo familiar para la consideración de las obras de Gombrowicz y de Copi, quienes establecen con Borges una relación ambigua en la que la coincidencia de ciertas preocupaciones, dispositivos genéricos y artimañas narrativas coexiste con el desafío, la irreverencia y la rebeldía ante el pudor paterno. El recorrido planteado por Estéticas bastardas se abre en tres derroteros que terminan por converger: una revisión de planteos teóricos en torno al mito, una indagación del género de la autoficción y una mirada sobre los modos de la filiación y el desvío en la construcción del sistema literario argentino.","palabras_clave":"JOSE AMICOLA|COPI|GOMBROWICZ|BASTARDÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75392,"idioma_id":4,"titulo":"Intracellularly induced cyclophilins play an important role in the stress adaptation and virulence of Brucella abortus","resumen":"Brucella is an intracellular bacterial pathogen that causes the worldwide zoonotic disease brucellosis. Brucella virulence relies on its ability to transition to an intracellular lifestyle within host cells. Thus this pathogen must sense its intracellular localization and then reprogram gene expression for survival within the host cell. A comparative proteomic investigation was performed to identify differentially expressed proteins potentially relevant for Brucella intracellular adaptation. Two proteins identified as cyclophilins (CypA and CypB) were overexpressed in the intracellular environment of the host cell in comparison to laboratory-grown Brucella. To define the potential role of cyclophilins in Brucella virulence, a double deletion mutant was constructed and its resulting phenotype was characterized. B. abortus &#8710;cypAB mutant displayed an increased sensitivity to environmental stressors such as oxidative, pH, and detergents. In addition, the B. abortus &#8710;cypAB mutant strain had a reduced growth rate at lower temperature, a phenotype associated to a defective expression of cyclophilins in other microorganisms. B. abortus &#8710;cypAB mutant also displays a reduced virulence in BALB\/c mice and a defective intracellular survival in HeLa cells. These findings suggest that cyclophilins are important for Brucella virulence and survival in the host cells.","palabras_clave":"BRUCELLA|CYCLOPHILLINS|STRESS|ADAPTATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75532,"idioma_id":5,"titulo":"El deterioro ambiental en manifestaciones rupestres: un caso de estudio del oeste tinogasteño (Catamarca, Argentina).","resumen":"Desde el punto de vista de los estudios químicos y espectroscópicos se discuten los diferentes pasos del trabajo de caracterización analítica de las muestras, focalizándose en los procesos fisicoquímicos que ocurren en las manifestaciones rupestres expuestas a factores ambientales. Se destaca el uso de técnicas vibracionales, tales como la microscopia Raman y la espectroscopia infrarroja, para el análisis de materiales orgánicos e inorgánicos. Se presentan como ejemplo los resultados del análisis realizado sobre las muestras de las imágenes pintadas en dos de los paneles de la cueva de La Salamanca (Depto. Tinogasta, Catamarca) explicitando las evidencias de deterioro mediante la realización de análisis fisicoquímicos.Palabras clave: deterioro, microscopia Raman, manifestaciones rupestres, hematita, yeso, weddellita, Catamarca","palabras_clave":"DETERIORO|MICROSCOPIA RAMAN|MANIFESTACIONES RUPESTRES|HEMATITA- WEDDELLITA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75802,"idioma_id":4,"titulo":"Antibacterial activity of extracts obtained from Senna corymbosa and Tipuana tipu","resumen":"Ethereal (E), dichloromethane (DCM), and ethyl acetate (EA) extracts from aerial parts of Senna corymbosa Lam. and Tipuana tipu (Benth.) Kuntze (Fabaceae\/Leguminosae) were analyzed for in vitro antimicrobial activity by broth microdilution assay against bacterial organisms like Staphylococcus aureus (ATCC 43300), S. aureus (ATCC 25923), Listeria monocytogenes (CLIP 74910), Escherichia coli (ATCC 35218) and Pseudomonas aeruginosa (ATCC 27853) at the concentrations of 8000 to 125 &#956;g\/mL. Ethyl acetate extracts of both species acting against Staphylococcus and Listeria with MIC values from 250 - 500 &#956;g\/mL. The MIC values of ethereal extract of T. tipu was 2000 &#956;g\/mL and 1000 &#956;g\/mL against S. aureus and L. monocytogenes respectively, while the ethereal extract of S. corymbosa only showed activity against Listeria (MIC= 4000 &#956;g\/mL). The ethyl acetate extracts of both plants inhibited E. coli (MIC= 4000 µg\/mL). These results suggest that both species are revealed as new source of natural antibacterial principles. This activity had not been reported until now.","palabras_clave":"Senna corymbosa|Tipuana tipu|Antibacterial properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75950,"idioma_id":5,"titulo":"Aislamiento de bacterias de origen lácteo y evaluación de propiedades probióticas y tecnológicas. Selección de cepas con actividad B-galactosidasa","resumen":"En las últimas décadas el desarrollo de alimentos funcionales ha centrado el interés de la industria alimenticia debido a la alta demanda mundial de alimentos saludables por parte de los consumidores. En este sentido, los alimentos conteniendo microorganismos probióticos y\/o compuestos prebióticos han recibido particular atención. Una de las primeras propiedades benéficas asignadas a los microorganismos probióticos es su capacidad para contribuir al metabolismo intestinal de la lactosa de la dieta, aliviando los síntomas de intolerancia. Este efecto es mediado por la enzima B-galactosidasa de los microorganismos incluidos en el producto, la cual puede hidrolizar este disacárido en el alimento antes del consumo, pero también contribuir a la digestión intraintestinal del mismo. Sin embargo, la enzima B-galactosidasa tiene mayores potencialidades biotecnológicas abriendo un abanico de posibilidades para su aplicación. Esta enzima, dependiendo de las condiciones de reacción (concentración de sustrato, aw, pH, temperatura) presenta actividad hidrolasa o transferasa, dando esta última, lugar a la formación de oligosacáridos de 2 a 10 unidades por reacciones de transglicosilación que consisten en la transferencia de residuos de galactosa a la lactosa y a los diferentes oligómeros que se van generando. Los GOS son conocidos compuestos prebióticos que pueden modular positivamente la composición de la microflora colónica además de tener aplicaciones como endulzantes dietéticos y no cariogénicos. La materia prima para su generación puede ser la lactosa de la leche o el suero de quesería, el cual es un desecho de la industria láctea considerado contaminante para el medio ambiente por lo que su aprovechamiento resulta una alternativa atractiva.&nbsp;  En el contexto planteado, el objetivo general del proyecto es aislar cepas de origen l¨¢cteo con conocido potencial probiótico (bacterias lácticas) y evaluar su capacidad para hidrolizar y transgalactosilar lactosa a los fines de contribuir al metabolismo de lactosa como microorganismos probióticos y\/o generar galactooligosacaridos prebióticos. Para ello, se determinación las principales características bioquímicas de la enzima B-galactosidasa de los microorganismos que presenten las actividades hidrolíticas mas elevadas y se evaluarán los perfiles de oligosacáridos generados por su actividad transferasa en diferentes condiciones de fermentación. El efecto prebiótico de los mismos será evaluado sobre cultivos puros de bifidobacterias y en homogenatos cecales de ratones que serán usados como modelo de microbiota colónica. Finalmente se evaluará la sobrevida de los microorganismos seleccionados por sus propiedades y su enzima B-galactosidasa a las condiciones del tracto intestinal y a ciertos parámetros tecnológicos.  Los resultados que se obtengan del presente proyecto, representarán un paso inicial en la selección de microorganismos probióticos que deberán ser complementados en el futuro mediante ensayos in vivo (en modelos animales y clínicos)&nbsp;y un aporte significativo a la ciencia básica con potencial aplicación en el área del desarrollo de alimentos funcionales, en particular un producto fermentado enriquecido en GOS y B-galactosidasa.                                                                                                           ","palabras_clave":"PROBIOTICOS|BACTERIAS LACTICAS|B-GALACTOSIDASA|PREBIOTICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":75983,"idioma_id":5,"titulo":"PARTE 2: Alternativas para enfrentar las actuales exigencias del mercado de espárrago (Asparagus officinalis L.) verde en Argentina. 2. Tendencias de la demanda","resumen":"El espárrago constituye una hortaliza muy valorada a nivel global, cuya difusión en Argentina es limitada, por lo cual se requiere de estrategias para fomentar su consumo. A tal fin se realizó una  encuesta (10\/11\/2009) en Azul, Argentina, estudiando: preferencias acerca del consumo, beneficios de su consumo (B), calibre (C) y longitud (L) de turiones, tipo de envase (E), conocimiento sobre vida útil  de las presentaciones (TVU), presencia de etiquetas (PE) y características como color de fondo (CF) y de letras (CL), lugar de compra (LC), tiempo (Ti) desde la compra hasta el consumo y prioridad (P) para la compra (calidad o precio), entre otros ítems. Los encuestados manifestaron preferencias de consumo de espárragos verdes y en platos calientes, mostrando desinterés por el consumo de  espárragos enlatados. En B, > 95 % demostró conocer las propiedades nutricionales y saludables de los espárragos. 71 % mostró interés por calibre mediano y un 75 % cortos (15-20 cm). Respecto de E, prefirieron las presentaciones en bandejas y atados con film, y con presencia de etiquetas, color de fondo llamativo (naranja y amarillo) y letra negra. El 81,1 % adquieren espárragos mediante venta directa y 50 % manifestó que transcurre entre 2 días y 1 semana entre la adquisición y el consumo, prefiriéndolos frescos y no congelados. En P, el 90 % priorizó calidad en lugar del precio. Estos resultados indican que los consumidores no son indiferentes a los atributos de presentación del  producto, por lo cual los empresarios deberían esforzarse por mejorar las dimensiones de la calidad del producto, por lo que se verían recompensados.","palabras_clave":"CALIBRES DE TURIONES|CONSUMIDORES DE ESPARRAGOS|ETIQUETAS|PREFERENCIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76039,"idioma_id":4,"titulo":"The functional interaction between acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target","resumen":"The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms the cells into a highly aggressive phenotype and controls both lipooxygenase-5 (LOX-5) and cyclooxygenase-2 (COX-2) metabolism of AA, suggesting a causal role of ACSL4 in tumorigenesis. We hypothesized that ACSL4, LOX-5 and COX-2 may constitute potential therapeutic targets for the control of tumor growth. Therefore, the aim of this study was to use a tetracycline Tet-Off system of MCF-7 xenograft model of breast cancer to confirm the effect of ACSL4 overexpression on tumor growth in vivo. We also aim to determine whether a combinatorial inhibition of the ACSL4-LOX-COX-2 pathway affects tumor growth in vivo using a xenograft model based on MDA-MB-231 cells, a highly aggressive breast cancer cell line naturally overexpressing ACSL4. The first novel finding is that stable transfection of MCF-7 cells with ACSL4 using the tetracycline Tet-Off system of MCF-7 cells resulted in development of growing tumors when injected into nude mice. Tumor xenograft development measured in animals that received doxycycline resulted in tumor growth inhibition. The tumors presented marked nuclear polymorphism, high mitotic index and low expression of estrogen and progesterone receptor. These results demonstrate the transformational capacity of ACSL4 overexpression. We examined the effect of a combination of inhibitors of ACSL4, LOX-5 and COX-2 on MDA-MB-231 tumor xenografts. This treatment markedly reduced tumor growth in doses of these inhibitors that were otherwise ineffective when used alone, indicating a synergistic effect of the compounds. Our results suggest that these enzymes interact functionally and form an integrated system that operates in a concerted manner to regulate tumor growth and consequently may be potential therapeutic targets for the control of proliferation as well as metastatic potential of cancer cells.","palabras_clave":"cyclooxygenase 2|tumor growth|proliferation|inhibition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76454,"idioma_id":5,"titulo":"Principales aportes de la perspectiva de género para el estudio social y reflexivo de la ciencia, la tecnología y la innovación","resumen":"Este artículo tiene como objetivo trazar un recorrido de los principales aportes dela perspectiva de género para la comprensión de la ciencia, la tecnología y la innovación (CTI). La inclusión de esta perspectiva dentro del campo CTS acontecida en las últimas décadas, ha enriquecido la comprensión de las múltiples relaciones que se entraman entre el dispositivo ciencia-tecnología-innovación y las subjetividades contemporáneas.El propósito de esta presentación es acercar al campo disciplinar del Diseño un modo de análisis que permitiría avanzar en estudios reflexivos, en tanto proceso epistemológico fundamental, sobre las dinámicas de producción, difusión y uso de conocimientos proyectuales. Para ello se proponen posibles abordajes metodológicos y se formulan preguntas abiertas que habilitarían futuros diálogos entre la relación género - CTI y el estudio del Diseño.","palabras_clave":"CIENCIA|GÉNERO|INNOVACIÓN|TECNOLOGÍA|REFLEXIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76509,"idioma_id":5,"titulo":"Evaluacion de actividad biologica de especies vegetales nativas para su uso en tecnologia alimentaria","resumen":"En la actualidad existe un creciente inter¨¦s en el estudio de fitoqu¨ªmicos como nuevas fuentes de antioxidantes y antimicrobianos naturales para  utilizarlos en alimentos y preparados farmac¨¦uticos a fin de reemplazar los antioxidantes sint¨¦ticos, que son restringidos debido a su potencial toxicidad. Los flavonoides, se pueden encontrar en los vegetales y poseen propiedades antioxidantes. Se han estudiado estos compuestos en la prevenci¨®n de enfermedades ligadas al estr¨¦s oxidativo1. Las familias Fabaceae, Solanaceae y Zygophyllaceae, comprenden especies vegetales nativas de Am¨¦rica. Algunos miembros de estas familias, presentan diversas actividades biol¨®gicas 2.    El objetivo de este trabajo fue estudiar la actividad biol¨®gica de plantas conocidas en la medicina tradicional por sus propiedades de Amaicha del Valle y determinar compuestos fen¨®licos totales para establecer una correlaci¨®n entre ambos. Las especies seleccionadas fueron: Bulnesia schickendantzii,  Larrea divaricata, Plectrocarpa rougesii, Zuccagnia punctata, Lycium chilense y Fabiana sp. Se determin¨® la capacidad antioxidante seg¨²n m¨¦todo de DPPH3, resultando ser en todas las muestras superior al 76% para una concentraci¨®n de 100 ¦Ìg\/cm3. El contenido de compuestos fen¨®licos se determin¨® por la t¨¦cnica de  Folin¨CCiocalteau modificado 4. El resultado de fenoles totales siempre fue superior a 400 mg EAG\/ 100 gramos de muestra. Para determinar actividad antimicrobiana se aplic¨® la Bioautograf¨ªa en agar seg¨²n Rahalison5 modificado. Se emplearon: Escherichia coli (ATCC 259229) y Staphylococcus aureus (ATCC 25923). Z. punctata, L. divaricata y Fabiana sp. mostraron actividad frente a ambos microorganismos, presentes como pat¨®genos en alimentos.    Se concluye que tres de las especies estudiadas, poseen buena actividad antioxidante, altos contenidos de compuestos fen¨®licos y actividad antimicrobiana positiva por lo que se encarar¨¢ un estudio m¨¢s profundo para evaluarlas como futuros conservantes naturales y aplicarlos en tecnolog¨ªa de alimentos.    1 Veskoukis A, Tsatsakis AM, KouretasD. Cell Stress & Chap. 2012, 17:11¨C21. 2 HarborneJB and C. A.Williams, Phytochemistry  2000 55:481¨C504. 3 Schmeda-Hirschmann G., Tapia A., Theoduloz C., Rodriguez J., Lopez S., Feresin G.E. Z. Naturforschung 2004 59: 345- 353.  4 Tawaha, K.; Alali, Feras Q.; Gharaibeh, M.; Mohammad, M.; El-Elimat, T. Food Chemistry 2007 104:1372¨C1378. 5 Rahalison, L.; Hamburguer, M.; Hostettman, K.; Monod, M.; Frenk, E.  Phytochem. Anal. 1991, 2: 199-203.","palabras_clave":"Vegetales|Antimicrobiano|Antioxidante"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76510,"idioma_id":5,"titulo":"Determinación de metas de factores de riesgo para enfermedades no transmisibles para el año 2016","resumen":"Para fijar las metas en salud pública, es aconsejable utilizar un procedimiento científico riguroso que contemple el uso de toda la evidencia epidemiológica disponible. OBJETIVOS: Proyectar la evolución de los factores de riesgo para enfermedades no transmisibles y el potencial impacto de distintas intervenciones poblacionales sobre su prevalencia. MÉTODOS: Se utilizó el software STELLA® para proyectar la evolución de la prevalencia de los factores de riesgo en un escenario basal (sin intervención) y se modelaron los efectos que podrían tener distintas intervenciones para determinar su impacto. RESULTADOS: Según las estimaciones para 2016, la prevalencia de tabaquismo, hipertensión arterial, hipercolesterolemia, diabetes, obesidad e inactividad física será de 24,9%, 35,7%, 31,1%, 11,7%, 22,8% y 65,0% respectivamente, en caso de mantenerse la tendencia actual. Sin embargo, la implementación de intervenciones poblacionales podría revertir esta tendencia y reducir las prevalencias a 22,1%, 31,7%, 27,6%, 10,6%, 20,2% y 60,0% respectivamente. CONCLUSIONES: Aunque se espera un aumento en los factores de riesgo, la implementación de intervenciones poblacionales podría disminuir la carga de las enfermedades no transmisibles en Argentina.","palabras_clave":"metas|enfermedades no transmisibles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76517,"idioma_id":5,"titulo":"Poder, Territorio y construcción de entorno: consideraciones políticas y metodológicas de los abordajes sobre los cuerpos y las emociones","resumen":"Las reflexiones que presentamos a continuación se centran en indagar y exponer la dimensión política que porta un abordaje sociológico sobre los   cuerpos. Guy Debord, en el 67? escribía La sociedad del espectáculo. Un texto que todavía, como relámpago que parpadea en el instante de peligro en un sentido benjaminiano, nos atraviesa e interpela en su inconclusividad: aún no podemos vislumbrar en su totalidad la dinámica del espectáculo como esa forma de relación social de dominación. De allí que este texto nos reinscribe en un conflicto aún no develado\/revelado y por ende, abierto al devenir; es decir, a poder seguir pensando la política en su operatoria sobre cuerpos y sensibilidades. Pero además -y por otra parte- este tipo de interrogaciones instala la necesaria problematización   metodológica orientada a la producción de condiciones de observabilidad y reflexividad sobre los mecanismos que actúan en la modelación-modulación de la experiencia presente-viviente. Se trata de poder indagar sobre nuestros cuerpos en geometrías y gramáticas que recartografían su capacidad política, como capacidades de moverse-actuar, en escenarios de creciente mercantilización y mediatización de la experiencia. Retomando y re-elaborando algunas nociones de este pensador, junto a algunos Desarrollos concretados por Paul Virilio - un continuador de la reflexión de W. Benjamin, para algunos estudiosos- presentamos la siguiente estrategia expositiva y argumentativa: en primer lugar, presentamos los aportes centrales para dar cuenta del re-enmarcamiento de nuestra experiencia: la noción de estado de sitio temporo-espacial expresa una convergencia de perspectivas que condensan en esta noción los cambios fundamentales y fundacionales de la experiencia presente en clave de tiempo y espacio. En segundo lugar, concretamos algunas consideraciones teóricas sobre la relación poder territorio y anticipamos la noción de ?entorno protegido? como un concepto con productividad descriptiva y analítica para dar cuenta de formas hegemónicas de regulación de las sensaciones, en la formación social contemporánea. En tercer lugar, damos cuenta de la dimensión política que porta el mismo objeto de Interrogación: la experiencia corporal como lugar de instanciación de diversas resultantes de la dialéctica entre estética y política, ya enunciadas en la consideración benjaminiana. Finalmente, proponemos algunas consideraciones metodológicas orientadas a potenciar la reflexividad sobre ese objeto oscuro que es la experiencia, en vistas a aportar algunas pistas para pensar la paradójica expresión que inicia estas reflexiones: si lo mas profundo es la piel, los abordajes sociológicos críticos de los cuerpos y las emociones aparecen como un topos de lucha epistémica y política para sublevar y desanestesiar los estados de sentir de nuestros cuerpos.Indexación: Latindex Catálogo","palabras_clave":"CUERPO|ENTORNO|CONDICIONES DE REFLEXIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76642,"idioma_id":5,"titulo":"Daños causados y sufridos por menores (segunda parte): los daños en la actividad deportiva y recreativa","resumen":"Daños causados y sufridos por menores (segunda parte): los daños en la actividad deportiva y recreativa. Editorial: Revista Abeledo Perrot, Buenos AiresDirector Carlos E. Camps, nº 4, mayo de 2012, pág. 489 a 526, ISSN 1852-0693.","palabras_clave":"Daños|Menores|Jurisprudencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76718,"idioma_id":5,"titulo":"ESTUDIO DE LA TEMPERATURA DEL SUELO EN UN INVERNADERO EN LA PATAGONIA ANDINA. MEJORA A TRAVÉS DE AISLAMIENTO TÉRMICO","resumen":"Se investigó la temperatura del suelo en el exterior y dentro de un invernadero, con el objetivo de encontrarmejoras a las condiciones existentes en los invernaderos de la región Andino Patagónica. Esta región se encuentra en la zonabioclimática VI, de clima muy frío. El cultivo de hortalizas, tanto en invernadero como en exterior, es posible y se obtienenproducciones significativas en los meses de verano. Dada una irradiación solar alta en primavera, verano y otoño, el ambienteen los invernaderos alcanza temperaturas adecuadas en estas 3 estaciones. Sin embargo, se observan temperaturas de suelomuy bajas en la primavera, las cuales retardan el crecimiento de plantines y de cultivos. Se estudió un invernadero de 47 m2situado en el periurbano de la ciudad de Bariloche (RN). Se realizaron mejoras con aislamiento térmico en los laterales,bordes inferiores, y vereda perimetral, y se estudiaron los cambios respecto a la situación sin aislamiento. Se obtuvieronmejoras substanciales en las temperaturas del suelo en el otoño e invierno.","palabras_clave":"Invernadero en zona muy fría|Aporte de calor en muros|Monitoreo anual|Comportamiento en invierno"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76815,"idioma_id":4,"titulo":"Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma","resumen":"Melanoma accounts for the majority of deaths from skin cancer. Women tend to be diagnosed at a younger age and have better survival than men. A tumor-host interaction might be responsible for these gender-specific differences. Recently, a functional single-nucleotide polymorphism in the promoter of the human homolog of mouse double minute 2 (MDM2) gene was characterized: single-nucleotide polymorphism (SNP)309 increases the MDM2 transcription. In melanoma, the effects for SNP309 and the related tumor protein p53 (TP53) Arg72Pro are inconsistent among published reports. This study investigated the association between SNP309 (RefSNP accession ID (rs)2279744) and TP53 codon 72 (rs1042522) polymorphisms, with outcome in a hospital-based cohort of 990 patients with melanoma. We assessed whether these polymorphisms were associated with clinicopathological and phenotypic characteristics and whether these SNPs affect the age of onset of the disease, recurrence, and survival. No significant associations were found between the SNPs and survival. However, women carrying the SNP309 GG genotype were less likely to be diagnosed at a younger age: odds ratio adjusted<50 0.52 (0.29-0.92). Our results suggest that women carrying the SNP309 GG genotype might be at lower risk of developing melanoma at a younger age compared with those carrying TG or TT. Further studies are needed to determine whether a nearby functional polymorphism is responsible for this effect in premenopausal women. © 2012 The Society for Investigative Dermatology.","palabras_clave":"MELANOMA|POLYMORPHISM|MDM2|TP53"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":76835,"idioma_id":4,"titulo":"Sylvester's double sums: an inductive proof of the general case","resumen":"In 1853 J. Sylvester introduced a family of double sum expressions for two finite sets of indeterminates and showed that some members of the family are essentially the polynomial subresultants of the monic polynomials associated with these sets.In 2009, in a joint work&nbsp; with C. D´Andrea and H. Hong&nbsp; we gave the complete description of all the members of the family as expressions in the coefficients of these polynomials.More recently, M.-F. Roy and A. Szpirglas presented a new and natural inductive proof for the cases&nbsp; considered by Sylvester.Here we show how induction also allows to obtain the full description of Sylvester´s double-sums.","palabras_clave":"subresultants|double-sum formula|induction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77131,"idioma_id":5,"titulo":"Perspectivas sobre la biopolítica en la obra de Deleuze","resumen":"Este trabajo aborda la cuestión del biopoder en la obra de Gilles Deleuze. En primer lugar, nos detenemos en 'Mille Plateaux' y en 'Foucault' a fin de poner de relieve los rasgos distintivos de su interpretación de la problemática foucaulteana. En el caso del primer texto, examinamos el contexto de aparición del concepto y exploramos el perfil que adopta el biopoder a partir de los abordajes de la vida y el poder presentes en el libro. Con relación al segundo, desplegamos las perspectivas deleuzeanas acerca de la muerte del hombre y la exterioridad de la vida respecto del poder, lo cual nos permite explicitar divergencias filosóficas entre su enfoque y el de Foucault. Luego, argumentamos que el concepto deleuzeano de control expuesto en 'Post-scriptum sur les sociétés de contrôle' traduce lo esencial del concepto foucaulteano de seguridad desarrollado en sus cursos biopolíticos. Sostenemos que esta concurrencia ilumina aspectos de la actual sociedad del biopoder vinculados con su lógica de funcionamiento, las mutaciones en el capitalismo, la transformación en los modos de subjetivación y las dificultades políticas planteadas por la nueva modalidad del poder. ","palabras_clave":"DELEUZE|FOUCAULT|BIOPOLÍTICA|CONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77432,"idioma_id":4,"titulo":"Gender violence: femicides in Argentina","resumen":"his paper presents the research results on femicides carried out in Argentina during the period 2008-2009 (Fernández et al., 2009). We emphasize one of the main outcomes: suicide-homicide tension linked to inconsistencies in keeping case records. From this point, we question how femicides can be covered up, among patriarchy, ferociousness and State abandonment.","palabras_clave":"FEMICIDES|STATISTICS|SUICIDE-HOMICIDE TENSION|PATRIARCHY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77580,"idioma_id":4,"titulo":"The influence of climate change, site type, and disturbance on stand dynamics in northwest British Columbia, Canada.","resumen":"Stand and disturbance dynamics are key processes that need to be assessed along withclimate-species interactions if we are to better understand the impacts of climate change on species. In this study we investigated the biotic interactions (competition) between species, the influence of disturbance type, and changes in resource availability (moisture and light) on the response of six tree species to climate change in the northwest region of central British Columbia, Canada. Two ecological models were parameterized, linked together and coupled to climate change scenarios to explore the interactions between: (1) the response of species in the regeneration phase and (2) the role of disturbance, resource availability and competition on determining stand composition and productivity. Climate change was found to reduce soil moisture availability which resulted in a decline in regeneration potential for all species on dry sites and negative to neutral responses on sites with higher water availability. Following fire, stand dynamics and composition were modeled to undergo significant changes under the 2080s climate compared to current climate conditions on dry and mesic sites. Changes in stand dynamics under climate change were marginal following bark beetle disturbances. While significant changes to stand dynamics were found on dry sites, the presented results suggest that the sites with the highest moisture availability maintain the same general stand dynamics and composition following disturbances under climate change. This study highlights the need to consider species response to climate change in interaction with existing stand conditions, disturbance type, competition, resource availability, not just temperature and precipitation.","palabras_clave":"boreal|climate change|competition|disturbance|modeling|SORTIE|stand dynamics|TACA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77584,"idioma_id":5,"titulo":"Representaciones de la revolución independentista en el cine argentino del período silente","resumen":"Como en otros países de Latinoamérica (Chile, México, Bolivia), el cine de ficción surgió en la Argentina en coincidencia con los festejos del primer Centenario de su revolución independentista, en un momento de conmemoración y reflexión acerca de esos procesos fundacionales de la historia nacional. Nuestra hipótesis para el presente trabajo es que ese género emergió a nivel local ante una necesidad de representar esos sucesos altamente simbólicos con medios expresivos que excedían los del cine de actualidades. En efecto, el género argumental permitía, mucho más fácilmente que el documental, rescatar la historia patria y operar con símbolos de identificación con el criollismo, la utopía agraria o el culto al honor. La Revolución de Mayo y la Declaración de la Independencia, como sucesos patrióticos claves del pasado nacional fueron temas recurrentes de estos primeros films de ficción. Sin embargo, lejos de proponer una representación fiel o precisa de la historia vernácula, estos relatos tenían como propósito desarrollar un sentimiento de pertenencia englobado en las ideas de lo nacional y de un destino común, exacerbando las mitologías que sirvieron para legitimar esos particulares órdenes políticos.&nbsp;","palabras_clave":"REPRESENTACIONES DE LA REVOLUCIÓN INDEPENDENTISTA|CINE DE FICCIÓN|CENTENARIO DE LA REVOLUCIÓN DE MAYO|CINE EDUCATIVO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77585,"idioma_id":5,"titulo":"Entre la educación y el espectáculo: La construcción de la alteridad en los primeros travelogues argentinos (1896-1933)","resumen":"A medio camino entre la educación y el espectáculo, el travelogue o film de viaje, cumplió a principios del siglo XX un doble propósito: trasladar virtualmente al espectador a los espacios representados, por un lado y legitimar la intervención en los territorios coloniales o la conquista y expansión de los territorios nacionales dominados por el indio, por el otro. En este trabajo, estudiamos los íntimos lazos que vincularon al viaje con&nbsp;las nuevas técnicas de reproducción mecánica desde ese doble carácter de dispositivos virtuales de exploración e instrumentos civilizatorios, y analizamos las múltiples estrategias formales, temáticas y discursivas que el travelogue retomó de la fotografía en función de esas dos facetas. ","palabras_clave":"CINE EDUCATIVO|DISPOSITIVOS VIRTUALES|REPRESENTACIONES ETNO-GEOGRAFICAS|TRAVELOGUES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77591,"idioma_id":5,"titulo":"En busca del tiempo perdido. De la fotografía monumento a los primeros ensayos de movimiento","resumen":"Entre la segunda mitad del siglo XIX y los primerosaños del XX, los sucesivos desarrollos en el campo de la tecnología parecieronconvertir al movimiento en una suerte de condición fundamental de todas lasartes. En efecto, este período se caracterizó por una creciente proliferaciónde aparatos ópticos y por un profundo cambio en la concepción del movimientofísico y en la naturaleza de la percepción, que produjeron un fuerte impacto enel panorama cultural de Occidente. En este trabajo estudiaremos una serie detécnicas y procedimientos con base fotográfica que, hacia la segunda mitad delsiglo XIX, sirvieron para transmitir la idea de movilidad en una imagen única yfija. Intentaremos poner en evidencia cómo la reproducción del movimiento y lavoluntad de representar el fluir del tiempo no fueron prerrogativas del cine,sino que ya aparecían preanunciadas en toda una serie de técnicas y formatostan heterogéneos como la exposición múltiple, la multifotografía o lafotografía panorámica, entre otros. Dado que este ensayo se inserta dentro deuna investigación mayor que aborda las múltiples relaciones que vincularon a lafotografía y al cine en la Argentina de fines del siglo XIX y principios del XX,el foco del presente trabajo remite sobre todo a la iconografía producida ocirculante en este particular contexto espacio-temporal.","palabras_clave":"PRECINEMATOGRAFÍA|ENSAYOS DE MOVIMIENTO|FOTOGRAFÍA PANORÁMICA|EXPOSICIÓN MÚLTIPLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77673,"idioma_id":5,"titulo":"Notas sobre la subalternidad desde una lectura fanoniana","resumen":"Es muy frecuente que en los análisis del concepto de subalternidad, las fuentes del período descolonizador que se inicia a mediados del siglo XX estén escasamente representadas debido a una preeminencia de la perspectiva filológica sobre el concepto, antes bien que a  una política e histórica. Este trabajo es un intento por incluir en el debate los textos de Frantz Fanon, quién reflexionó largamente sobre los problemas de la subjetividad en el colonialismo y en los procesos descolonizadores. De ese modo,se intenta conectar aquella  escritura con una memoria epistémica poscolonial.  Cuerpo-subjetividad-cultura nacional-Fanon-decolonization        Too often in the analysis of the concept of subalternity, sources from the decolonization period (late 40s, and 50s, XXth Century) are poorly represented due to a predominance of the philological perspective on the concept rather than a political and historical. This paper is an attempt to broaden the debate trough Frantz Fanon´s texts. Fanon mused at length  about the problems of subjectivity in colonialism and decolonization processes. In that way, we try to connect that wrinting to a postcolonial epistemic memory.    Body-subjetivity-national culture-Fanon-descolonizaciónIndizada en Latindex Directorio-Latindex Catálogo. CAICYT.","palabras_clave":"CUERPO|SUBJETIVIDAD|FANON|NACIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77698,"idioma_id":4,"titulo":"Prevalence of cardiovascular risk factors among Latin American","resumen":"WCC 2012 Abstract submissionHealth promotion in nursingWCC12-ABS-1979PREVALENCE OF CARDIOVASCULAR RISK FACTORS IN A POPULATION DOING EXERCISES. Kerbage 1, C. Barrios 1,*, J. Sierralta 2, J. Silva 1, I. De Urquiza 2, A. Angelino 1, M. Di Loretto 31Cardiac and Pulmonar Rehabilitation , FAVALORO FOUNDATION, 2Cardiac and Pulmonar Rehabilitation ,FUNDACION FAVALORO, Buenos Aires, 3Neumonology, FUNDACION FAVALORO, Buenos Aires , ArgentinaIntroduction: It is known that physical exercise has a positive impact on the correction of risk factors and therefore in theprevention of cardiovascular disease.It is necessary to emphasize in education programs for the community, in this aspect nursing intervention is essential.Objectives: To learn about the prevalence of cardiovascular risk factors (CVRF) in people attending an outdoor eventheld on Sunday 20th, March, 2011 at the Rosedal in Palermo, organized by the Undersecretariat of Sports of theGovernment of Buenos Aires within the framework of the ?Doing exercise? program.Methods: The nursing staff of the Educational Program for Prevention and Cardiovascular and Pulmonary Rehabilitationdesigned a survey about CVRFs to collect data provided by the individuals attending the event. Nursing interventionsincluded the following: surveys, exhaled carbon monoxide (CO) measurements, anthropometric measurements and vitalsigns recording. After each survey and measurement, the nursing staff gave educational recommendations as deemedconvenient. Special emphasis was made on a sedentary lifestyle since it has been proven that regular exercise helpscontrol risk factors (smoking, obesity, stress, etc). Finally, printed material about general prevention was given out.Results: 120 persons were interviewed (females 67%, males 33%, age range 13-82 years. Seventy eight percent of thepopulation walks; 40% more than three times a week. Sixty five percent does exercise regularly; the most popularactivities being aerobics, gym, cycling, yoga, swimming, tango and salsa dancing. Eighty eight per cent pointed out thatfruit and vegetables were included in their diet. Forty four per cent had a BMI over 25. Forty two per cent hadhypertension (controlled hypertension). Sixteen per cent smoked, and the CO measurement evidenced that 20% wereheavy smokers (CO between 16 and 25).Conclusion: Hypertension, smoking and a BMI over 25 were observed even in a population doing aerobic exercise,which shows that an effort must be made to create awareness in terms of education to modify all cardiovascular riskfactors.Disclosure of Interest: S. Kerbage Employee for: Favaloro Foundation, C. Barrios Employee for: Favaloro Foundation,J. Sierralta Employee for: Favaloro Foundation, J. Silva Employee for: Favaloro Foundation, I. De Urquiza Employee for:Favaloro Foundation, A. Angelino Employee for: Favaloro Foundation, M. Di Loretto Employee for: Favaloro Foundation","palabras_clave":"cardiovascular health|pediatrics; population|risk factors|low-and-middle countries"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77760,"idioma_id":5,"titulo":"Negar la otredad. Anomalía, peligro y locura en una tesis de principios del siglo XX, Argentina","resumen":"El presente artículo se propone analizar discursivamente una tesis doctoral elaborada por el médico Emilio Catalán, a principios del siglo XX. La importancia de la misma reside, a nuestro entender, en que reúne no sólo aportes teóricos que la ubican en sintonía con los postulados del alienismo internacionalizado, sino también casos clínicos que evidencian la aplicación de los axiomas que defiende. La figura de este profesional de la medicalización se refuerza tanto por su aparición en otros ámbitos de discusión científica, como por las posibilidades que su tesis ofrece a la comprensión del tratamiento social y biomédico que la locura recibió en la Argentina del Centenario. Nuestro objetivo radica en percibir las implicancias del discurso sobre los procesos de interiorización de la alienación mental en el cuerpo social. El marco de análisis se nutrirá de los aportes de Judith Butler sobre el carácter performativo del discurso, propuestas de Marc Angenot respecto a la hegemonía en el discurso social, así como sobre elaboraciones de Michel Foucault en cuanto a la enfermedad mental, la normalización y los dispositivos disciplinares.","palabras_clave":"Locura|Argentina del siglo XX|Performatividad|Hegemonia discursiva"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":77907,"idioma_id":4,"titulo":"A new species of Rhytidognathus (Carabidae,Migadopini) from Argentina.","resumen":"The Migadopini are a small tribe of Carabidae with 47 species that occur in South America, Australia, and New Zealand, in the sub-Antarctic areas. In South America, most of the genera inhabit areas related to sub-Antartic Nothofagus forest except two monogeneric genera, the Ecuadorian genus Aquilex Moret and the Pampean genus Rhytidognathus Chaudoir. These two genera are geographically isolated from the remaining five South American genera. New material of Rhytidognathus from the northeast of Buenos Aires province and from Entre Ríos province permits establishing that the previous records of Rhytidognathus ovalis (Dejean) for Argentina were erroneous and that it belongs to a new species. Based on external morphological characters and from male and female genitalia we describe Rhytidognathus platensis as a new species. In this contribution we provide illustrations, keys, habitat characteristics and some biogeographic considerations on the distribution of Rhytidognathus.","palabras_clave":"Migadopini|South America|Rhythydognathus|Biogeography"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78035,"idioma_id":5,"titulo":"Nuevos objetos de la historia: los estudios turísticos en una perspectiva comparada.","resumen":"La historia del turismo no ha sido un objeto apreciado por la historiografía en general y prácticamente desconocido en el escenario nacional.  Es relativamente reciente el interés de los historiadores sociales por estas problemáticas relacionadas con el esparcimiento popular y el debate del ocio y la recreación. Y, si bien, durante los últimos años se ha llegado a reconocer las oportunidades que otorga ampliar el interés en las problemáticas que presentan su exploración, su conocimiento todavía es muy irregular. La mayoría de los historiadores  ven la historia del turismo como un tema frívolo, una actividad meramente lúdica y algo que no es digno de estudios académicos.  Los buenos estudios sobre el turismo son obra de los antropólogos, sociólogos y geógrafos y su enfoque principal tiende a centrarse en cuestiones muy contemporáneas. Sin embargo, en los último quince años se viene notado un cambio de rumbo con la aceptación, en especial dentro del mundo anglosajón como el también el europeo continental, de la importancia de problemáticas asociadas al abordaje del  turismo, vacaciones, ocio, sociabilidad, consumo y esparcimiento popular. Tal interés ha surgido en cierto modo como parte de la agenda de la nueva historia con su énfasis en el individuo y el consumo, aunque sin desdeñar una adecuada comprensión de los fenómenos en juego utilizando el vocabulario de clases, rangos y categorías sociales. Estas novedosas perspectivas ayudan al momento de efectuar preguntas y definir proyectos, especialmente cuando pensamos en los conflictos sociales que surgen alrededor de comportamientos y espacios, como el papel de las capitales de veraneo, cuando  se convertían en el centro político del país o de la provincia (Brighton antes de la reina Victoria, San Sebastián durante los reinados de María Cristina y Alfonso XIII, o Mar del Plata en el siglo XX). Asimismo el rol de las políticas públicas y su relación con las prácticas provenientes de la sociedad civil, y el análisis de los consumos e infraestructuras turísticas (transportes, residencias, servicios).","palabras_clave":"HISTORIA|HISTORIOGRAFÍA|TURISMO|SOCIEDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78176,"idioma_id":5,"titulo":"Estudio  comparativo  de  competencias  emocionales  según  grupo  de  edad en la ciudad de Mar del Plata.","resumen":"sta investigación se enmarca dentro del paradigma de la Psicología Positiva y de la Teoría delCurso Vital. Propone explorar las características una serie de Competencias Emocionales demujeres y varones de la ciudad de Mar del Plata de cinco grupos de edad: 1) 13 a 18 años, 2) 30a 35 años, 3) 47 a 52 años, 4) 64 a 69 años y 5) 81 a 86 años. El diseño será de tipo noexperimental, transversal\/correlacional. La muestra se seleccionará de manera no probabilísticaintencional y constará de 400 sujetos de ambos sexos -80 casos por grupo de edad-. Seadministrarán los siguientes instrumentos de recolección de datos A) Cuestionario de variablessociodemográficas; B) Competencias emocionales: 1) Cuestionario de Competencias yHabilidades emocionales, 2) Escala de toma de perspectiva, 3) Escala de preocupación empáticay 4) Escala de Estrategias de Regulación emocional ante el conflicto interpersonal. Los datosrecogidos a partir de la aplicación de los instrumentos estandarizados serán analizadoscuantitativamente mediante paquetes estadísticos informatizados. Los resultados contribuirán aldesarrollo de la psicología del curso vital en Argentina, específicamente en el área lascompetencias emocionales intra e interpersonales.","palabras_clave":"competencias emocionales|conflictos interpersonales|grupos de edad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78199,"idioma_id":4,"titulo":"Adult patients with sporadic polycystic kidney disease: the importance of screening for mutations in the PKD1 and PKD2 genes","resumen":"Background&nbsp;&nbsp;&nbsp; ADPKD is one of the most common inherited disorders, with high risk for end-stage renal disease. Numerous patients, however, have no relatives in whom this disorder is known and are unsure whether they may transmit the disease to their offsprings. The aim of this study was to evaluate whether germline mutation analysis adds substantial information to clinical symptoms for diagnosis of ADPKD in these patients.&nbsp; Methods&nbsp;&nbsp;&nbsp; Clinical data included renal function and presence of liver or pancreas cysts, heart valve insufficiency, intracranial aneurysms, colonic diverticles, and abdominal hernias. Family history was evaluated regarding ADPKD. Germline mutation screening of the PKD1 and PKD2 genes was performed for intragenic mutations and for large deletions.&nbsp; Results&nbsp;&nbsp;&nbsp; A total of 324 adult patients with ADPKD including 30 patients without a family history of ADPKD (sporadic cases) were included. PKD1 mutations were found in 24\/30 and PKD2 mutations in 6 patients. Liver cysts were present in 14 patients and intracranial aneurysms in 2 patients. Fourteen patients (45%) had no extrarenal involvement. Compared to the 294 patients with familial ADPKD, the clinical characteristics and the age at the start of dialysis were similar in those with sporadic ADPKD.&nbsp; Conclusion&nbsp;&nbsp;&nbsp; The clinical characteristics of patients with sporadic and familial ADPKD are similar, but sporadic ADPKD is often overlooked because of the absence of a family history. Molecular genetic screening for germline mutations in both PKD1 and PKD2 genes is essential for the definitive diagnosis of ADPKD.","palabras_clave":"ADPKD|PKD1|PKD2|CHRONIC RENAL DISEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78201,"idioma_id":4,"titulo":"Characteristics of Intracranial Aneurysms in the Else Kroener-Fresenius Registry of Autosomal Dominant Polycystic Kidney Disease","resumen":"Background: Patients who harbor intracranial aneurysms (IAs) run a risk for aneurysm rupture and subsequent subarachnoid hemorrhage which frequently results in permanent deficits or death. Prophylactic treatment of unruptured aneurysms is possible and recommended depending on the size and location of the aneurysm as well as patient age and condition. IAs are major manifestations of autosomal dominant polycystic kidney disease (ADPKD). Current guidelines do not suggest surveillance of IAs in ADPKD except in the setting of family history if IA was known in any relative with ADPKD. Management of IAs in ADPKD is problematic because limited data exist from large studies. Methods: We established the Else Kröner-Fresenius Registry for ADPKD in Germany. Clinical data were assessed for age at diagnosis of IAs, stage of renal insufficiency, and number, location and size of IAs as well as family history of cerebral events. Patients with symptomatic or asymptomatic IAs were included. All patients with ADPKD-related IAs were offered mutation scanning of the susceptibility genes for ADPKD, the PKD1 and PKD2 genes. Results: Of 463 eligible ADPKD patients from the population base of Germany, 32 (7%) were found to have IAs, diagnosed at the age of 2?71 years, 19 females and 13 males. Twenty (63%) of these 32 patients were symptomatic, whereas IAs were detected in an asymptomatic stage in 12 patients. IAs were multifocal in 12 and unifocal in 20 patients. In 26 patients (81%), IAs were diagnosed before end-stage renal failure. Twenty-five out of 27 unrelated index cases (93%) had no IAs or cerebral events documented in their relatives with ADPKD. In 16 unrelated index patients and 3 relatives, we detected germline mutations. The mutations were randomly distributed across the PKD1 gene in 14 and the PKD2 gene in 2 index cases. Questionnaires answered for 320\/441 ADPKD patients without IAs revealed that only 45\/320 (14%) had MR angiography.Conclusion: In ADPKD, rupture of IAs occurs frequently before the start of dialysis, is only infrequently associated with a family history of IAs or subarachnoid hemorrhage, and is associated with mutations either of the PKD1 or the PKD2 gene of any type. Screening for IAs is widely insufficiently performed, should not be restricted to families with a history of cerebral events and should be started before end-stage renal failure.","palabras_clave":"INTRACRANIAL ANEURYSMS|AUTOSOMAL DOMINANT POLYCYSTIC DISEASE|PREVENTIVE MEDICINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78206,"idioma_id":4,"titulo":"OVARIECTOMY CAUSES OVEREXPRESSION OF RENAL NA+,K+-ATPASE AND SODIUM SENSITIVE HYPERTENSION IN ADULT WISTAR RATS","resumen":"We investigated the effect of ovariectomy on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated&nbsp; Na+, K+-ATPase á 1 subunit (t-d-NKA) in normotensive Wistar rats under a normal (NS, 0.24%) or high sodium (HS, 1%) intake vs&nbsp; intact female (IF). On NS t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (p&lt;0.01 vs IF) and renal plasma flow was increased. Upon HS, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium and developed arterial hypertension (134±4 vs IF 112±5 mmHg, p&lt;0.05).&nbsp; Sodium load caused salt sensitive hypertension in oVx Wistar rats. ","palabras_clave":"OVARIECTOMY|RENAL-Na,KATPase-PHOSPHOSTATE|SODIUM-SENSITIVE-HYPERTENSION|mTAL|SEXUAL-HORMONES|SODIUM-EXCRETION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78301,"idioma_id":5,"titulo":"Métodos de cosecha forestal que combinan conservación de la biodiversidad y los ciclos naturales del bosque primario con la producción maderera en Tierra del Fuego","resumen":"Los bosques de Nothofagus pumilio (lenga) en Tierra del Fuego han sido utilizados por los pueblos originarios desde hace miles de años, pero su aprovechamiento a gran escala comenzó con la colonización europea, incluyendo incendios, remoción de árboles y posterior conversión a pastizales. Miles de hectáreas de bosque fueron transformadas para la ganadería (e.g., cerca de 30 mil ha en el sector argentino), donde algunos sectores recuperaron parcialmente su cobertura forestal. Estas áreas recuperadas generaron bosques secundarios, aunque recuperaron su cobertura forestales no recuperaron completamente sus funciones ecosistémicas ni los niveles de biodiversidad precosecha. Numerosas propuestas silvícolas se han implementado desde principios del siglo pasado hasta la actualidad para los bosques de Tierra del Fuego (talas rasas en fajas, cortas de selección, cortas de protección, cortas en bosquetes). Sin embargo, desde principios de la década de los `80 se planteó a nivel mundial la necesidad de establecer nuevas alternativas silviculturales que incluyan a la conservación de la biodiversidad y los ciclos naturales del bosque en la toma de decisiones en el marco del manejo forestal a largo plazo.","palabras_clave":"propuestas silvícolas|Tierra del Fuego"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78329,"idioma_id":4,"titulo":"Long term variations in rodent abundance in a rural landscape of the Pampa, Argentina","resumen":"Abstract The goal of this study was to analyze thevariations in abundance of rodent communities over thelast 24 years in a rural area, and their relation to possiblechanges in climatic variables and land use. Theprincipal change in the area observed along the studyperiod was an increase in the area covered by soybean.The habitats studied were crop fields and borders. Thetotal abundance of rodents did not show a significanttrend of variation over time in crop fields while in bordersthe abundance in autumn\u2013winter (A\u2013W) showed asignificant trend to decrease over time. The differentrodent species showed a differential response over time.While Calomys laucha and C. musculinus showed a decreasebetween the period before and after the soybeanexpansion, Akodon azarae did not change its abundanceover time. The mean minimum temperature increasedover time while the number of days with frost decreased.Total rodent abundance in A\u2013W was positively associatedwith the cumulated precipitation of the previousspring\u2013summer period and negatively with the cumulatedprecipitation of the same period. We conclude thatrodent abundance variations in crop fields and bordersof the study area are influenced by precipitation, but theobserved trends of variation over time are better explainedby changes in agricultural practices than bymeteorological variables.","palabras_clave":"RODENT|LAND USE|CLIMATE VARIATION|AGROECOSYSTEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78443,"idioma_id":4,"titulo":"Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFN&#947;, Perforin, and TNF&#945;, and due to the Elimination of Transduced Cells","resumen":"The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells. Herein, we demonstrate that during the elimination of transgene expression, the brain becomes infiltrated with CD4+ and CD8+ T cells and that these T cells are necessary for transgene elimination. Further, the loss of transgene-expressing brain cells fails to occur in the absence of IFN&#947;, perforin, and TNF&#945; receptor. Two methods to induce severe immune suppression in immunized animals also fail to restitute transgene expression, demonstrating the irreversibility of this process. The need for cytotoxic molecules and the irreversibility of the reduction in transgene expression suggested to us that elimination of transduced cells is responsible for the loss of transgene expression. A new experimental paradigm that discriminates between downregulation of transgene expression and the elimination of transduced cells demonstrates that transduced cells are lost from the brain upon the induction of a specific antiviral immune response. We conclude that the anti-adenoviral immune response reduces transgene expression in the brain through loss of transduced cells.","palabras_clave":"BRAIN ADAPTIVE IMMUNE RESPONSE|FIRST GENERATION ADENOVIRAL VECTORS|TRANSGENE EXPRESSION|TRANSDUCED BRAIN CELL LOSS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78712,"idioma_id":4,"titulo":"A leaf gas exchange model that accounts for intra-canopy variability by considering leaf nitrogen content and local acclimation to radiation in grapevine (Vitis vinifera L.)","resumen":"Understanding the distribution of gas exchange within aplant is a prerequisite for scaling up from leaves to canopies.We evaluated whether leaf traits were reliable predictors ofthe effects of leaf ageing and leaf irradiance on leaf photosyntheticcapacity (Vcmax, Jmax) in field-grown vines (Vitisvinifera L). Simultaneously,we measured gas exchange, leafmass per area (LMA) and nitrogen content (Nm) of leavesat different positions within the canopy and at differentphenological stages. Daily mean leaf irradiance cumulatedover 10 d (PPFD10) was obtained by 3D modelling of thecanopy structure. Nm decreased over the season in parallelto leaf ageing while LMA was mainly affected by leaf position.PPFD10 explained 66, 28 and 73% of the variation ofLMA, Nm and nitrogen content per area (Na), respectively.Nitrogen content per unit area (Na = LMA ¥ Nm) wasthe best predictor of the intra-canopy variability of leafphotosynthetic capacity. Finally, we developed a classicalphotosynthesis-stomatal conductance submodel and byintroducing Na as an input, the model accurately simulatedthe daily pattern of gas exchange for leaves at differentpositions in the canopy and at different phenological stagesduring the season.","palabras_clave":"3D structure|Canopy variability|leaf acclimation|light interception"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78747,"idioma_id":4,"titulo":"Effects of castration on citoprotective genes and apoptotic mechanisms in rat lung","resumen":"There is strong evidence that oxidative stress plays a key role in the pathophysiology of several lung diseases. The presence of specific androgens and estrogens receptors in the lung implies that sex hormones play a physiological role in pulmonary function. The present study was designed to determine whether castration and androgen replacement result in changes in the lung histoarchitecture. Wistar male rats (200± 20 g) were separated in three groups: controls (Co, n:6), castrated (Ca, n:6), and castrated replaced with testosterone (Ca+T,  n:6), 30 days after castrations. For light microscopy, the fixed tissues were dehydrated in an ascending series of ethanol, cleared in xylene, and embedded in paraffin. Each antibody was assayed in at least three sections of each lung from each individual. ANOVA was used for statistical analysis. The results indicate that Hsp 27 immunostaining decreased in Ca group (p<0.001), while Hsp 70i (p<0.01), PTEN (p< 0.05), PCNA and Bcl-2 (p<0.05) positive staining, were increased in the same group, compared to control.  In Ca + T group, all antibodies used were increased. In our experimental model, there is an important stress oxidative state, which could be accompanied with the impaired balance between pro and anti apoptotic and citoprotective genes, during injury. Moreover, the castration modified the rat lung tissue and testosterone replacement after castration produces a partial recuperation.","palabras_clave":"oxidative stress|estrogens receptors|lung"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78777,"idioma_id":5,"titulo":"Propuesta sobre Aprender Enseñando: desarrollo de un curso a distancia sobre Accesibilidad Web en manos de alumnos","resumen":"Hoy en día, donde las TICs están al alcance de la mano de todas las personas independientemente de la edad, cultura, formación y experiencias adquiridas, las cuestiones de usabilidad y accesibilidad son imprescindibles y deben ser incorporadas en todo producto informático de calidad. A pesar que existen normas de accesibilidad Web vigentes desde 1999, son innumerables los sitios Web que aun no las cumplen. Esto hace restringir el acceso a la Web únicamente a personas que operan la PC en situación inmejorable como ser el poseer el mejor monitor, conexión de alta velocidad, últimas versiones instaladas y sobre todo, tener las aptitudes mentales y físicas intactas. Cualquier otra persona que se encuentre en posición desfavorable puede llegar a quedar excluida de esta importante herramienta de comunicación y de información. Este artículo explica la innovación realizada en las técnicas de enseñanza sobre Accesibilidad Web a jóvenes que cursan el último año de la Facultad de Informática de la Universidad Nacional de La Plata, Argentina. Con el objeto de impactar sobre una comunidad de estudiantes a punto de graduarse, se los motivó a desarrollar un curso a distancia que explique a la comunidad el concepto, el sentido, las dimensiones de Accesibilidad desde varias perspectivas, informáticas, sociales, morales, educativas. Se pretendió con resultados exitosos que mediante la motivación de enseñar a los demás mediante un recurso educativo enriquecedor como el de un curso a distancia, el alumnado pueda aprender el tema en profundidad y asimilarlo para poder aplicarlo luego en su vida profesional. Formando así, un futuro informático capaz de desarrollar software de calidad que incluya a todo ser humano como potencial usuario del mismo.","palabras_clave":"Accesibilidad Web|Normas WCAG|Herramientas Asistivas|Educación a Distancia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78800,"idioma_id":5,"titulo":"Ensayos sobre la lengua poética en Cuba","resumen":"RESUMEN TÉCNICO: artículo de 46984 caracteres con espacios, publicado en una revista que se edita en Estados Unidos desde 1955 y es indexada en Arts & Humanities Citation Index (Thomson Reuters), MLA Bibliography, HLAS, entre otros índices internacionales. RESUMEN DE CONTENIDO: en varios ensayos escritos en Cuba a partir de la década de 1980, se pone de manifiesto la vigencia del valor asignado a los usos de la lengua en las transformaciones literarias y culturales producidas en la isla en el último siglo y el impulso a su discusión y resignificación. En este artículo se analizan dos modulaciones de este tópico. En primer lugar, la valoración de la oralidad cotidiana y barrial en relación irónica con el alcance de los prosaísmos del lenguaje revolucionario. En segundo lugar, la renovada indagación en torno de los elementos del choteo articulados ahora con rasgos del barroco. El artículo se vincula con el Plan de Trabajo en curso ya que analiza las actitudes ante la lengua literaria en el ensayo con especial atención al barroco.","palabras_clave":"LENGUA LITERARIA|CUBA|ENSAYO|SIGLO XX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78803,"idioma_id":5,"titulo":"La belleza de lo vivo: Alfonso Reyes ante la lengua popular","resumen":"RESUMEN TÉCNICO: artículo de 30080 caracteres con espacios, publicado en una revista que se edita en Brasil desde 2000 y somete los artículos a un referato internacional. RESUMEN DE CONTENIDO: Entre 1927 y 1937 Alfonso Reyes residió entre Buenos Aires y Río de Janeiro, donde analizó algunas de las categorías culturales que tensionaban el espacio intelectual mexicano. Entre ellas, exploró los usos estratégicos del archivo lingüístico popular y analizó su inserción en las poéticas contemporáneas. Este artículo analiza algunas de estas articulaciones. Se vincula con el Plan de Trabajo en curso ya que analiza las actitudes ante la lengua popular y su relación con la conceptualización contemporánea del barroco y está en relación con los objetivos del PIP 0333 'Redes intelectuales entre los universos letrado y popular en la cultura argentina 1920-1960: Análisis de prácticas discursivas y archivos documentales' dirigido por Gloria Chicote entre 2010 y 2012.","palabras_clave":"ALFONSO REYES|LENGUA POPULAR|POESÍA|LENGUA LITERARIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78822,"idioma_id":5,"titulo":"Desarrollo de un sistema informático para la administración de Historias Sociales de un Hospital Pediátrico Provincial","resumen":"La actividad de extensión que estamos presentando está dirigida al Hospital Interzonal deAgudos Especializado en Pediatría (HIAEP)1 de la ciudad de La Plata, provincia deBuenos Aires. Esta actividad comenzó después de varios encuentros entre docentes de lacátedra Taller de Tecnologías de Producción de Software (TTPS)2 de la Facultad deInformática y profesionales del Servicio Social del mencionado hospital pediátrico. Eldiálogo con los profesionales del servicio, que atiende a más de 80.000 niños por año,nos permitió evidenciar dificultades en cuanto al manejo de los datos de sus pacientes.Toda la información relacionada a las situaciones diagnósticas, estrategias yprocedimientos para la asistencia social de los niños y adolescentes que acuden alservicio son mantenidos en extensos formularios de papel, lo que provoca previsiblesdificultades en cuanto a su actualización, su recuperación y análisis. Esta informaciónimprescindible, constituye un capital valioso de ser recuperado y ordenado de modoaccesible para su utilización en nuevas instancias de asistencia a pacientes. Es en estemarco que advertimos la necesidad de contar con un sistema informático que facilite laactualización de la Historia Social (HS), asegure la inmediata recuperación de lainformación y garantice, además, la privacidad absoluta de los datos almacenados. Apartir de esta necesidad, en TTPS, además de enseñar los contenidos de la asignatura,se trabajó conjuntamente con los estudiantes para la producción de diferentes prototiposdel sistema de acuerdo a requerimientos relevados con los profesionales del servicio.Después de finalizados los diferentes prototipos, los trabajadores sociales fueron invitadosa nuestra Facultad donde se pudieron discutir-analizar las funcionalidades provistas porcada uno de ellos. A partir de este encuentro muy enriquecedor para todos losintervinientes, se comenzó a trabajar para integrar las funcionalidades acordadas. Cabedestacar que para la implementación del sistema, se han enseñado durante la cursada,tecnologías y frameworks FLOSS3 de amplio uso en la comunidad de desarrolladores deaplicaciones web. Queremos destacar también que los estudiantes se han mostrado muymotivados y comprometidos con esta actividad, conscientes de que además de participaren un proyecto real, están experimentando con tecnologías utilizadas en el mercadolaboral y participando de un desarrollo con fuerte impacto social. Se espera que el uso deeste sistema ayude a mejorar la calidad de la atención del servicio agilice el registro yrecuperación de la información y permita contar con estadísticas que ayuden a la revisióny re-diagramación de los programas de trabajo y las prioridades de este servicio socialdestinado a niños y adolescentes de nuestra ciudad.1 Sitio web del Hospital Interzonal de Agudos Especializado en Pediatría 'Sor María Ludovica',http:\/\/www.ludovica.org.ar\/inicio.html2 Materia obligatoria de 3er año de la Carrera Analista Programador Universitario de la Facultad deInformática de la UNLP.3 Hace referencia a tecnologías gratuitas. Su sigla viene del inglés Free\/Libre Open Source Software","palabras_clave":"salud|sistema informático|java"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78846,"idioma_id":5,"titulo":"Los artefactos líticos del Alero Carriqueo: informe de avance.","resumen":"El denominado alero Carriqueo se ubica en Norpatagonia, en la cuenca del río Limay. El actual sitio arqueológico fue recurrentemente habitado durante un amplio período. Hasta el presente el registro arqueológico, abundante y variado, se puede vincular al período ceramolítico de la región. En este trabajo brindamos información acerca de los resultados obtenidos luego del estudio morfológico-descriptivo de una muestra de artefactos líticos que hemos dividido en débitage lato sensu por un lado (débitage stricto sensu más las matrices bifaciales y los núcleos) y por el otro, en instrumentos. Todos proceden de las excavaciones realizadas en el sitio hasta la actualidad.","palabras_clave":"Alero Carriqueo|Estudios líticos|Tecnología |Nord-Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78873,"idioma_id":5,"titulo":"Periodismo argentino: en busca de datos sobre la profesión","resumen":"Argentina tiene una larga tradición en el periodismo, con instituciones académicas pioneras en la enseñanza de la profesión. Sin embargo, el desarrollo de los estudios sobre periodismo es aún incipiente, lo que se evidencia en los escasos trabajos sistemáticos que permitan realizar un diagnóstico de la situación de la profesión en el país.  Los estudios basados en algún tipo de encuesta por muestreo se concentran en los últimos quince años y provienen en gran medida de iniciativas de la sociedad civil. En su mayoría fueron realizados por consultoras con participación de unas pocas universidades. Aunque de diverso enfoque y alcance, casi todas las investigaciones coinciden en remarcar la escasez no solo de referencias de la situación de los periodistas sino de datos para dimensionar adecuadamente el universo de la profesión. Por ello, la  mayoría de las encuestas se centran principalmente en los periodistas de los grandes medios del distrito capital, más accesibles y mensurables, pero poco representativos del conjunto. Con estos antecedentes, las investigaciones disponibles se presentan como entrevistas exploratorias y se da a los resultados un carácter provisional.  La falta de datos estadísticos de los profesionales en ejercicio podría atribuirse a la carencia de registros centralizados de la actividad por la baja participación de los periodistas en instituciones del ámbito sindical y de la sociedad civil. Pero también ha influido el hecho de que los marcos teóricos propios de la sociología de las redacciones y los estudios de la producción noticiosa recién empezaron a difundirse en el país en la última década. Esta debilidad de la base epistemológica ha  diversificado las metodologías de abordaje al problema, que no siempre fueron las adecuadas para brindar un diagnóstico general de la profesión, aún pendiente.","palabras_clave":"Periodismo|Metodología de la Investigación|Cultura Periodística"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78877,"idioma_id":5,"titulo":"Investigación en relaciones públicas: viejos dilemas, nuevas demandas","resumen":"El nacimiento y desarrollo de las Relaciones públicas en la Argentina estuvo determinado por una impronta práctica y profesional, lo que determinó una trayectoria académica distinta a otras áreas de la comunicación. Su discusión teórica fue dejada de lado en los foros y espacios académicos locales hasta la actualidad, a pesar de que en las últimas décadas se consolidó una oferta importante de cursos de grado y posgrado. El presente artículo intenta hacer un breve recorrido por las principales corrientes teóricas que dominaron el campo de la comunicación en Argentina y sus temas de investigación, para tratar de entender su relación con los fenómenos que son objeto de estudio de las relaciones públicas. El desconocimiento de la disciplina abonó no pocos prejuicios hacia ella en el ámbito académico local, a pesar de que se trata de un área de estudios que requiere de abordajes multidisciplinarios, con sólidos antecedentes en el campo de las ciencias de la comunicación. Las Relaciones Públicas es un área de investigación que enfrenta el desafío de los profundos cambios, que demandan el abordaje desde metodologías y enfoques teóricos que den cuenta de los nuevos fenómenos. Traer a la discusión académica este campo de investigación no solo es necesario para integrarla a la producción de conocimiento de otros países de la región, sino que se hace imprescindible para dar sustento a la enseñanza y el análisis de las prácticas comunicacionales de las organizaciones.","palabras_clave":"Relaciones Públicas|Investigación en Comunicación|Teorías de la Comunicación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78882,"idioma_id":5,"titulo":"Las imágenes de las mujeres políticas en la era del politeinment y la postelevisión","resumen":"La mínima presencia de las mujeres en la política no es solo una característica en latinoamérica. En los últimos años fueron electas líderes para la Presidencia de la Nación en Chile, Argentina y Brasil, así como otras candidatas mujeres tuvieron participación destacada en Perú y México. En ese contexto, la promoción y difusión de imágenes de las mujeres políticas sigue atada a estereotipos clásicos, y se las presentan desde sus características maternales, protectoras o de alguna manera relacionadas a la fragilidad. Aquí buscamos discutir estas cuestiones teniendo como fundamentación en las teorías mediáticas de la televisión y la conformación de nuevos géneros como el politeitment.","palabras_clave":"Comunicación electoral|mujeres|medios|televisión"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78927,"idioma_id":5,"titulo":"El taller lítico LY-041-La Divisoria (departamento Pilcaniyeu, provincia de Río Negro)","resumen":"En el taller lítico LY 041-La Divisoria, situado en el sudoeste de la estepa rionegrina, se prepararon artefactos bifaciales en rocas dacíticas procedentes de la cercana cantera Paso Limay. Habría sido un satélite del alero Carriqueo, un pequeño sitio de vivienda muy próximo, del cual se habrían segregado algunas tareas de talla, que generan muchos desechos potencialmente molestos o peligrosos. Además, desde el sitio se tiene buena visibilidad del paisaje. Subsidiariamente, en LY 041-La Divisoria se habrían realizado algunas tareas de procesamiento de materiales orgánicos.  Este sitio corrobora que para los cazadores-recolectores de la comarca, la cantera Paso Limay tuvo un papel central en el aprovisionamiento de roca para puntas de proyectil.","palabras_clave":"Sitio La Divisoria|Río Negro|Estudios líticos|Análisis tecnomorfológico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78932,"idioma_id":5,"titulo":"Henri Bergson, o una filosofía menor sobre el control: principios, procedimientos y convergencias","resumen":"Teniendo en cuenta fundamentalmente las investigaciones de Henri Bergson acerca de las relaciones entre el pensamiento, el cerebro y la materia, y sumando asimismo las contribuciones que Gilles Deleuze y Maurizio Lazzarato han realizado a este respecto, el siguiente artículo propone un recorrido destinado a precisar los principios, procedimientos y convergencias que definen al 'control' como una modalidad novedosa de funcionamiento y de ejercicio del poder. En primer lugar, el recorrido sostendrá que el control se dirige fundamentalmente hacia la 'memoria' y la 'atención' en tanto fuerzas propias y constitutivas de la conciencia o el pensamiento; de igual manera, indicará que esas fuerzas tienden a exteriorizarse y actualizarse en una serie de movimientos esbozados ante todo en el cerebro y luego en el espacio. Posteriormente, y a partir de semejantes principios, advertirá que el control implica la 'modulación' de las exteriorizaciones del pensamiento, y agregará el hecho de que tal procedimiento se compone de imágenes y movimientos variables, de excitaciones y vibraciones cerebrales, propagadas a través de un universo etéreo. Así pues, y en último lugar, el recorrido indagará la posibilidad de que los procedimientos del control confluyan con las operaciones de una economía basada en la captura de la ?cooperación entre cerebros? o, si se quiere, de la fuerza de trabajo que despliega constantemente a la memoria y la atención para crear, propagar y efectuar mundos variables y diversos.","palabras_clave":"PENSAMIENTO|CEREBRO|ACCIONES VIRTUALES|RITMOS|INCITACIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":78936,"idioma_id":5,"titulo":"La 'formación permanente' de las sociedades de control: especificidades y contrariedades","resumen":"Gilles Deleuze señalaba que las 'sociedades de control' sustituyen a los compartimentos estancos de la formación disciplinaria por la 'formación permanente' en tanto ejercicio de un control continuo sobre los individuos. Teniendo en cuenta esta problemática, el presente artículo propone un recorrido dedicado a abordar las especificidades de aquella formación. En primer lugar, recurrirá a las investigaciones de Michel Foucault sobre el neoliberalismo y sostendrá que la formación permanente debe entenderse como una inversión en 'capital humano' que continuamente es incitada por intervenciones gubernamentales de carácter ambiental. En segundo lugar, el recorrido se apoyará en los aportes de Deleuze para concebir a dicha formación como una 'modulación' de las potencialidades el individuo. Finalmente, advertirá el hecho de que la formación permanente implica la implementación de 'múltiples formas' de inversión que por un lado incrementan las diferentes capacidades de los individuos y, por el otro, las ponen al servicio de la competencia económica.","palabras_clave":"NEOLIBERALISMO|INVERSIÓN EN CAPITAL HUMANO|OPERACIONES DE MOLDEADO Y DE MODULACIÓN|AUTODISCPLINAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79041,"idioma_id":5,"titulo":"Aplicabilidad de métodos de evaluación de la amenaza sísmica para un proyecto minero (basada en datos neotectónicos, instrumentales e históricos), Andes Centrales, San Juan, Argentina","resumen":"En el presente trabajo se presenta la metodología aplicada en el análisis de la amenaza sísmica para un sitio específico de los Andes argentinos. Se recopiló y analizó la información neotectónica y sismológica como tarea inicial del trabajo. Como es habitual en muchas regiones de Sudamérica, la información sismológica y paleosismológica disponible es escasa y, en general, insuficiente para definir acabadamente la actividad sísmica en el espacio y en el tiempo. Los criterios de verificación sísmica de las obras involucradas en el proyecto se definieron sobre la base de la práctica internacional. Las metodologías determinística y probabilística se aplicaron para la evaluación de la amenaza sísmica en el sitio del proyecto. Los resultados obtenidos se comparan en este trabajo y se discuten los procedimientos a utilizar para la selección de los movimientos sísmicos de diseño. Finalmente se define un criterio de trabajo y se presentan los movimientos sísmicos de diseño que resultaron del estudio.","palabras_clave":"NEOTECTONICA|AMENAZA|ACELERACION|RIESGO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79141,"idioma_id":5,"titulo":"Estudio de muertes por causas externas: tendencia de mortalidad por suicidio en jóvenes. Argentina  2000-2008.","resumen":"Objetivos: Analizar la tendencia de mortalidad por suicidio en Argentina en adolescentes y jóvenes de 10 a 24 años en el período 2000-2008, evaluando además la mortalidad por suicidio en el trienio 2005-2007 en el grupo de 5 a 24 años según sexo, método utilizado, lugar de ocurrencia y jurisdicción de residencia. Método: Se utilizaron las Bases de Datos de los Informes Estadísticos de Defunción y los Anuarios de Estadísticas Vitales. Se calcularon tasas de mortalidad por suicidio específicas por 100.000 habitantes, utilizando la clasificación de la CIE-10 (X60-X84). El análisis estadístico se llevó a cabo mediante regresión lineal y ANOVA.Resultados: las tasas de suicidio en el grupo de 10 a 24 años muestran un incremento en el periodo 2000 a 2003 y en varones una tendencia en ascenso en el período 2000-2005. En el trienio 2005-2007, en el grupo de 5 a 9 años se produjeron 6 defunciones por suicidio. En el grupo de 10 a 24 años el ahorcamiento y el disparo de arma de fuego fueron los métodos más frecuentes en varones (p&lt;0,01), incrementándose con la edad (p&lt;0,01). En Argentina las regiones del sur y noroeste del país presentan mayores tasas mientras que la pampeana y centro las más bajas. Conclusión: el suicidio en la población de adolescentes y jóvenes en Argentina sugiere la necesidad estudiar esta problemática, desde la perspectiva de género y autopsias psicológicas a fin de ampliar y profundizar acerca de los factores intervinientes.","palabras_clave":"ADOLESCENCIA|INTENTO DE SUICIDO|EPIDEMIOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79157,"idioma_id":4,"titulo":"Bolivia: the construction of an alternative science and technology policy","resumen":"AbstractThe aim of this paper is to analyze recent changes in Bolivia?s science and technology policy and contextualize them in the surrounding region. It is recognized that since the 1980s, Latin America initiated a series of changes in its science and technology policies driven by the needs of the economic accumulation regime prevalent and based on new theories of innovation. Policies placed their emphasis on the application of scientific technology in order to boost national competitiveness. During the 1990s, a closer link was established between the neoliberal regime of accumulation, science and technology policies, and the concept of innovation. The outcry from various social movements subsequently demanded a refocus of these policies towards a more regional and social orientation. The emergence of governments more critical of neoliberalism resulted in the need to rethink science and technology policies as shown by the experience of Brazil, Argentina, Venezuela, Bolivia and Ecuador. The transitional case of Bolivia is examined here so as to contribute to the larger discussion concerning Latin America?s science and technology policies.","palabras_clave":"BOLIVIA|SCIENCIE AND TECHNOLOGY|ALTERNATIVE POLICY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79237,"idioma_id":5,"titulo":"Protocolos de preguntas para relevar investigaciones en las cátedras: Criminalización de la infancia y delincuencia juvenil","resumen":"Protocolos de preguntas para relevar investigaciones en las cátedras","palabras_clave":"protocolo investigación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79253,"idioma_id":5,"titulo":"Encuadrando el delito: pánico moral en los periódicos Argentinos","resumen":"El asalto a Carolina Píparo a la salida de un banco en la provincia de Buenos Aires, Argentina, estremeció a la opinión pública por tratarse de una víctima embarazada que, a raíz de un disparo recibido en el ataque, debió someterse a una cesárea después de la cual su hijo sobrevivió sólo una semana. Este trabajo analiza el tipo de tratamiento que recibió el llamado caso Píparo a través de un análisis de contenido exploratorio e inductivo de la cobertura que los diarios Clarín y La Nación dieron al tema. El objetivo es elaborar un libro de códigos que pueda ser validado en estudios de casos similares mediante el análisis de contenido de la prensa gráfica. Se busca aplicar la teoría del Framing para, desde la detección de los encuadres noticiosos empleados, discutir si éstos son compatibles con el concepto de pánico moral planteado por Stanley Cohen. Indexada en: SCOPUS, DOAJ, HAPI, HLAS, IPSA, IBSS, PAIS, RedALyC, SAWPSA, RESH, IN-RECS, CIRC, ISOC, REDIB, MIAR, CCHS, LATINDEX, EBSCO, Proquest, The Philosopher?s Index, e-Revistas, QOAM (GRUPO A).","palabras_clave":"Pánico moral|Delito|Argentina|Medios gráficos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79409,"idioma_id":5,"titulo":"La jurisprudencia de derechos humanos en Argentina","resumen":"  En este trabajo se citarán los fallos de los tribunales provinciales, nacionales y de la  Comisión Interamericana de Derecho Humanos que han establecido jurisprudencia tanto a nivel  nacional como a nivel internacional de los derechos humanos en el marco de adhesión, de  aprobación; de ratificación y de entrada en vigor a los tratados internacionales de derecho  humanos en la Constitución Nacional Argentina. Hay una invocación al sistema de derecho a  través de un saber hacer y un conocer, que hace de la sociedad argentina sea caracterizada por  los órdenes de un discurso jurídico que enumera y clasifica, controla y codifica, narra y sentencia,  tipifica y condena o absuelve, en tanto derecho humano. Más allá de una posible o evidente  violación a un derecho ya establecido, la dinámica social exige, mediante un fundamentado  conocimiento, demandar a la estructura del derecho que otorgue subjetividad a los individuos en  tanto sujeto de derechos en caso de ser éstos han sido ultrajados y que dejan en estado de  desvalimiento jurídico, y por ende político, a individuos.","palabras_clave":"Reforma constitucional|Jurisprudencia|Fallo|Garantía"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79413,"idioma_id":5,"titulo":"Análisis ideológico de las movilizaciones sociales en la Argentina de los útlimos 40 años","resumen":"Las movilizaciones sociales de los últimos 40 años en la Argentina corresponden más a respuestas frente a las características del propio acontecer psíquico de la política institucional argentina, que a un mero fenómeno mundial de movilización de las masas modernas.El objetivo del trabajo es realizar un análisis que no se apoye en cierta idea dicotómica de la sociedad y no caer en el carácter erróneo de considerar la historia sólo como establecimiento de enfrentamiento de clases.Sería el proceso de alienación el que acentúa estas modalidades de lucha y de reclamo, ya que predominaría un cierto determinismo económico en el despliegue de movilización social que reclama por dignidad, libertad, vida, seguridad, salud, educación, expresión.Para Zizek el psicoanálisis puede delinear la economía simbólica de cómo podemos romper el círculo vicioso que engendra la clausura ?totalitaria? del conflicto de clases. Para nosotros, el aporte de Foucault nos ayuda a desprendernos de cierta ilusión de esta totalidad.Siguiendo el concepto de la biopolítica de Foucault, la resistencia de las movilizaciones argentinas encontró su saber, no en la visibilidad de la calle y en la superposición de derechos, sino en la geografía de la economía del libre tránsito.","palabras_clave":"Movilizaciones sociales|Alienación|Disciplinamiento|Biopolítica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79416,"idioma_id":5,"titulo":"Incidencia de la proliferación de ONGs en la subjetividad de los argentinos","resumen":"Las movilizaciones sociales de los últimos 40 años en la Argentina corresponden más a respuestas frente a las características del propio acontecer psíquico de la política institucional argentina, que a un mero fenómeno mundial de movilización de las masas modernas.El objetivo del trabajo es realizar un análisis que no se apoye en cierta idea dicotómica de la sociedad y no caer en el carácter erróneo de considerar la historia sólo como establecimiento de enfrentamiento de clases.Sería el proceso de alienación el que acentúa estas modalidades de lucha y de reclamo, ya que predominaría un cierto determinismo económico en el despliegue de movilización social que reclama por dignidad, libertad, vida, seguridad, salud, educación, expresión.Para Zizek el psicoanálisis puede delinear la economía simbólica de cómo podemos romper el círculo vicioso que engendra la clausura ?totalitaria? del conflicto de clases. Para nosotros, el aporte de Foucault nos ayuda a desprendernos de cierta ilusión de esta totalidad.Siguiendo el concepto de la biopolítica de Foucault, la resistencia de las movilizaciones argentinas encontró su saber, no en la visibilidad de la calle y en la superposición de derechos, sino en la geografía de la economía del libre tránsito.","palabras_clave":"ONGs|Organismos Internacionales|Estado|Subjetividad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79452,"idioma_id":5,"titulo":"Guillermo L. Allende: su recuerdo y su legado","resumen":"Breve estudio del pensamiento de Guillermo Allende y suinfluencia en la doctrina actual de los derechos reales","palabras_clave":"HOMENAJE A JURISTA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79454,"idioma_id":5,"titulo":"Fraude a la ley: su análisis y su recepción en el Proyecto de Código Civil","resumen":"Análisis de la figura del fraude a la ley, su comparación con los vicios de la voluntad y ponderación de diversos ejemplos. Especial atención sobre su recepción en el Proyecto de Código Civil y Comercial de la Nación 2012.","palabras_clave":"FRAUDE A LA LEY|ACTO JURÍDICO|VICIO DE LA VOLUNTAD|PROYECTO DE CÓDIGO CIVIL Y COMERCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79458,"idioma_id":5,"titulo":"La propiedad indígena comunitaria: un análisis crítico del artículado del Proyecto de Código Civil y Comercial Unificado","resumen":"Análisis de la regulación de la propiedad indígena ysus más destacadas características en el Proyecto de Código Civil y Comercialde la Nación 2012","palabras_clave":"CONSTITUCIÓN NACIONAL|PROPIEDAD INDÍGENA|CONVENIOS INTERNACIONALES|PROYECTO DE CÓDIGO CIVIL Y COMERCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79463,"idioma_id":5,"titulo":"El psicólogo en la Formación Docente de primarios y secundarios: función de coordinación","resumen":"El Objetivo es mostrar el acompañamiento que desde la psicología se puede realizar, fomentando procesos de salud mental, en alumnos de carreras de profesorados desde el comienzo de sus prácticas pre-profesionales como futuros docentes. La función de coordinación del ?taller de reflexión?, entendido éste como dispositivo pedagógico provocador de cambios, propone acciones que tienden a lograr la circulación de significados, la toma de conciencia, la comprensión, la elaboración de interpretaciones e iniciación de procesos de reflexión por parte de los participantes. A través de la narración de la experiencia y del proceso reflexivo sobre las prácticas, uno de los niveles de intervención desde la psicología es coordinando y articulando las expectativas que los alumnos construyen en relación con sus prácticas y por supuesto, sobre sus propias potencialidades y capacidades, como así también sobre sus fantasías. La psicología funciona como herramienta que dinamiza las relaciones que se producen entre el educando, el educador y el conocimiento; y que socializa las experiencias individuales al hacer explícitas las formas en que el sentido de la vida cultural educativa se construye.","palabras_clave":"Reflexión|Coordinación|Experiencia|Identidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79479,"idioma_id":4,"titulo":"Biophysical assessment of AQP9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol","resumen":"BACKGROUND INFORMATION:           Lipolytic glycerol, released from   adipocytes, flows through bloodstream to the liver where its utilization   in supplying hepatocyte gluconeogenesis is rate-limited by the   permeation step. An aquaglyceroporin expressed in hepatocytes, AQP9, has   been often linked to liver uptake of glycerol. However, the   truthfulness of this postulation as well as the potential existence of   additional pathways of glycerol import by hepatocytes have never been   assessed directly. Here, we define the identity and extent of liver   glycerol transport and evaluate the correlation between hepatic AQP9   expression and glycerol permeability in AQP9(+\/+)  wild type mice in   different nutritional states and circulating insulin levels. The liver   glycerol permeability of AQP9 null mice is also assessed.          RESULTS:           By   stopped-flow light scattering, facilitated diffusion of glycerol into   hepatocytes was indicated by the low Arrhenius activation energy (3.5   kcal\/mole) and strong inhibition by phloretin, an AQP9 blocker, that   characterized the transport. While fasting markedly increased hepatic   AQP9 a straight parallelism was seen both in quantitative and time-space   terms between glycerol permeability and AQP9 protein in AQP9(+\/+)  mice   kept in fed or fasted\/refed states. In line with these findings, the   highest glycerol permeability (P(gly)  &#8776; 14.0 x 10(-6)  cm\/s at 20 C),   at 18-hours fasting, coincided with the highest percent of phloretin   inhibition (63%). Besides being markedly lower than in AQP9(+\/+)  mice   the liver P(gly)  of the AQP9 null mice did not increase during fasting.   RT-PCR analysis showed lack of compensation by AQP3 and AQP7, the other   known murine glycerol facilitators, in AQP9 null mice.          CONCLUSIONS:           Overall,   these results prove experimentally major functional significance for   AQP9 in maximizing liver glycerol import during states requiring   increased glucose production. If any, alternative facilitated pathways   would be of minor importance in transporting glucogenetic glycerol into   hepatocytes during starvation. Refining the understanding of liver AQP9   in metabolic and energy homeostasis may reveal helpful for therapeutic   purposes.","palabras_clave":"aquaporin-9|liver|glycerol|transport"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79682,"idioma_id":5,"titulo":"¿Excepcionalidad o especificidad?  Sendas  problemáticas de la identidad latinoamericana","resumen":"Procuramos  rastrear algunas expresiones que han nutrido las corrientes   culturales  alentadoras de la excepcionalidad de la cultura   latinoamericana. Asimismo,  intentaremos articular las consecuencias de   estas formaciones discursivas a la  problemática de la   Modernidad, en   virtud de que la polarización entre  identidad-modernidad ha sido   privativa de los debates sobre la cultura  latinoamericana. Por último   es de nuestro interés ensayar la posibilidad de ver  la noción de   especificidad como mejor situada para la caracterización de los  bienes   simbólicos latinoamericanos.","palabras_clave":"identidad, |especificidad|excepcionalidad|modernidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79701,"idioma_id":4,"titulo":"X-ray evaluation of dislocation density in ODS-Eurofer steel","resumen":"The dislocation density of ferritic-martensitic oxide dispersion strengthened ODS-Eurofer steel was evaluated by using the modified Williamson-Hall method (peak broadening analysis). Measurements were performed in several metallurgical conditions (ferritic and martensitic structures). The monochromatic X-ray radiation was provided by a synchrotron source. The results match qualitatively with those provided by Vickers microhardness measurements and metallographic inspection using transmission electron microscopy.","palabras_clave":"ODS|ferritic-martensitic steels|dislocation density|X-ray diffraction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79748,"idioma_id":4,"titulo":"A New insight into the evolution of aquaporins from flowering plants and vertebrates: orthologous identification and functional transfer is possible new insight into the phylogeny of aquaporins","resumen":"Aquaporins (AQPs) comprise a diverse family of channel protein which transport water and\/or small solutes across cell membranes in the three domains of life. In plants, there are four subfamilies of AQPs named PIP, TIP, NIP and SIP while in animals the AQPs are commonly classified in orthodox aquaporins and aquaglyceroporins. Recently, experimental data showed that individual proteins belonging to the same subfamily are located in different compartments and\/or could transport different solutes, showing that prediction of AQPs function from sequence is a major challenge. This problem is enhanced by the absence of AQPs trees that reflect the organismal phylogeny. ","palabras_clave":"aquaporins|evolution|gene transfer"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79772,"idioma_id":4,"titulo":"Modified basal elements in Dicroidium fronds (Corystospermales)","resumen":"We describe a distinct type of heteromorphic basal frond element in four species of the seed-fern  foliage Dicroidium, based principally on a survey of plant-fossil collections from the Triassic of  Antarctica. The modified foliar elements are conspicuously enlarged, and arise at wide angles  and obliquely to the frond plane. Those of D. elongatum and D. crassinerve arise more or less  directly from the petiole base; they are overall wedge- to fan-shaped with variably dissected  margins and fan-shaped venation. Those of D. odontopteroides and D. dubium are (sub)circular,  reniform, or obcordate, also with fan-shaped venation, or divided into narrow tongue-shaped  segments with alethopteroid venation. The basal elements of some species commonly occur  isolated. By analogy with comparable structures among other plant groups, we conclude that the  basal elements represent a distinct, early leaf-ontogenetic architectural unit in the frond bauplan  of Dicroidium, which provides an important additional character for a more accurate delimitation  and systematic classification. Similar structures also occur on the corystosperm reproductive  organs Umkomasia and Pteruchus. It appears that the basal elements were particularly common  among high-latitude Dicroidium trees that flourished in a strongly seasonal light regime. We  hypothesize that the modified elements may represent the initial foliar outgrowths during spring  flush, ensuring a rapid re-initiation of sap flow and metabolic activity after the extended period  of winter dormancy.  ","palabras_clave":"CYCLOPTERID|APHLEBIA|STIPULE|ORGANOGRAPHY|TAXONOMY|PALAOECOLOGY|SEED FERNS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79775,"idioma_id":4,"titulo":"A new Neocalamites (Sphenophyta) with prickles and attached cones from the Upper Triassic of China","resumen":"Remains of the extinct sphenophyte (horsetail) Neocalamites are most widespread in the Middle\u2013Upper Triassic and are typically represented  by stem and leaf fragments. Here we report on spectacular new finds of Neocalamites from the Late Triassic Yangcaogou Formation in Liaoning  Province, China that include bedding surfaces dominated by nearly complete aerial stems with attached leaf whorls and rare bractless cones.  They reveal a monopodial growth habit for the stems, which are covered with downward projecting prickles that probably provided protection  against herbivores. These features provide the basis for a new proposed species, Neocalamites horridus. The nodes bear whorls of very long leaves  mainly free to their bases, and one specimen bears an attached cone on a long peduncle. Identical dispersed cones have also been recovered. The  leaves of adjacent monopodial stems most likely interlocked to support growth in large stands akin to the role now played by branches in large  modern Equisetum species. The new Chinese Neocalamites is among the most confidently reconstructed species, and indicates a greater diversity  of sphenophyte morphology during the Mesozoic than previously realized.","palabras_clave":"CHINA|HORSETAILS|LIAONING|NEOCALAMITES|SPHENOPHYTA|TRIASSIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79797,"idioma_id":4,"titulo":"Disinfectant efficacy of sodium hypochlorite and quaternary ammonium compounds against planktonic and sessile yeast cells isolated from concentrated apple juice industry","resumen":"In this work, we evaluated the effectiveness of sodium hypochlorite and a commercial quaternary ammonium compound against four wild yeast strains in their different growth forms: planktonic, sessile and forming microcolonies. These yeasts had been isolated from apple juice processing plant, and appropriate environmental conditions were employed throughout the work. For planktonic cells, 4- Log reduction was obtained using the lowest concentration of sodium hypochlorite (200 ppm) on all tested strains. However, quaternary ammonium chloride was effective only on Zygosaccharomyces sp. in all in-use concentration tested, and only the stronger in-use concentration (1:30) was effective on Rhodotorula mucilaginosa. Because of the above results, the disinfection on sessile yeast cells was performed only with sodium hypochlorite solutions. In cells attached in batch conditions, the highest concentration of sodium hypochlorite (500 ppm) was necessary to get 4-Log reduction. In order to obtain a 3-Log reduction on Zygosaccharomyces sp. microcolonies formed in laminar flow conditions, the combined action of 0.5 % w\/v NaOH and 500 ppm sodium hypochlorite was required. We concluded thus cells forming microcolonies under laminar flow conditions were less susceptible to disinfectants that those suspended or attached in batch conditions. These results also indicated that attachment and colonization of autochthonous yeasts must be properly identified to evaluate the effectiveness of disinfectants used in apple juice processing plants.","palabras_clave":"YEAST|BIOFILM|CLEANING|DISINFECTANT|STAINLESS STEEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79818,"idioma_id":4,"titulo":"Evaluation of different genetic procedures for the generation of artificial hybrids in Saccharomyces genus for winemaking","resumen":"Several methods based on recombinant DNA techniques have been proposed for yeast strain improvement; however, the most relevant oenological traits depend on a multitude of loci, making these techniques difficult to apply. In this way, hybridization techniques involving two complete genomes became interesting. Natural hybrid strains between different Saccharomyces species have been detected in diverse fermented beverages including wine, cider and beer. These hybrids seem to be better adapted to fluctuating situations typically observed in fermentations due to the acquisition of particular physiological properties of both parental strains.In this work we evaluated the usefulness of three different hybridization methods: spore to spore mating, rare-mating and protoplast fusion for the generation of intra- and inter-specific stable hybrids, being the first report about the comparison of different methods to obtain artificial hybrids to be used in fermentations. Spore to spore mating is an easy but time-consuming method; hybrids generated with this technique could lack some of the industrially relevant traits present in the parental strains because of the segregation occurred during meiosis and spore generation prior to hybridization. Hybrids obtained by protoplast fusion get the complete information of both parents but they are currently considered as genetically modified organisms (GMOs). Finally, hybrids obtained by rare-mating are easily obtained by the optimized methodology described in this work, they originally contain a complete set of chromosomes of both parents and they are not considered as GMOs. Hybrids obtained by means of the three methodological approaches showed a high genetic variability; however, a loss of genetic material was detected in most of them. Based on these results, it became evident that a last crucial aspect to be considered in every hybridization program is the genetic stabilization of recently generated hybrids that guarantee its invariability during future industrial utilization. In this work, a wine yeast genetic stabilization process was developed and vegetatively stable hybrids were obtained.","palabras_clave":"SACCHAROMYCES CEREVISIAE|SACCHAROMYCES KUDRIAVZEVII|ARTIFICIAL HYBRIDS|RARE-MATING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79820,"idioma_id":4,"titulo":"Comparative genomics among Saccharomyces cerevisiae x Saccharomyces kudriavzevii natural hybrid strains isolated from wine and beer reveals different origins","resumen":"Background: Interspecific hybrids between S. cerevisiae × S. kudriavzevii have frequently been detected in wine and beer fermentations. Significant physiological differences among parental and hybrid strains under different stress conditions have been evidenced. In this study, we used comparative genome hybridization analysis to evaluate the genome composition of different S. cerevisiae × S. kudriavzevii natural hybrids isolated from wine and beer fermentations to infer their evolutionary origins and to figure out the potential role of common S. kudriavzevii genefraction present in these hybrids. Results: Comparative genomic hybridization (CGH) and ploidy analyses carried out in this study confirmed the presence of individual and differential chromosomal composition patterns for most S. cerevisiae × S. kudriavzevii hybrids from beer and wine. All hybrids share a common set of depleted S. cerevisiae genes, which also are depleted or absent in the wine strains studied so far, and the presence a common set of S. kudriavzevii genes, which may be associated with their capability to grow at low temperatures. Finally, a maximum parsimony analysis of chromosomal rearrangement events, occurred in the hybrid genomes, indicated the presence of two maingroups of wine hybrids and different divergent lineages of brewing strains.Conclusion: Our data suggest that wine and beer S. cerevisiae × S. kudriavzevii hybrids have been originated by different rare-mating events involving a diploid wine S. cerevisiae and a haploid or diploid European S. kudriavzevii strains. Hybrids maintain several S. kudriavzevii genes involved in cold adaptation as well as those related to S. kudriavzevii mitochondrial functions.","palabras_clave":"SACCHAROMYCES CEREVISIAE|SACCHAROMYCES KUDRIAVZEVII|BEER|WINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79822,"idioma_id":4,"titulo":"Reconstruction of the evolutionary history of Saccharomyces cerevisiae x S. kudriavzevii hybrids based on multilocus sequence analysis","resumen":"In recent years, interspecific hybridization and introgression are increasingly recognized as significant events in the evolution of Saccharomyces yeasts. These mechanisms have probably been involved in the origin of novel yeast genotypes and phenotypes, which in due course were to colonize and predominate in the new fermentative environments created by human manipulation. The particular conditions in which hybrids arose are still unknown, as well as the number of possible hybridization events that generated the whole set of natural hybrids described in the literature during recent years. In this study, we could infer at least six different hybridization events that originated a set of 26 S. cerevisiae x S. kudriavzevii hybrids isolated from both fermentative and non-fermentative environments. Different wine S. cerevisiae strains and European S.kudriavzevii strains were probably involved in the hybridization events according to gene sequence information, as well as from previous data on their genome composition and ploidy. Finally, we postulate that these hybrids may have originated after the introduction of vine growing and winemaking practices by the Romans to the present Northern vine-growing limits and spread during the expansion of improved viticulture and enology practices that occurred during the Late Middle Ages.","palabras_clave":"SACCHAROMYCES CEREVISIAE|SACCHAROMYCES KUDRIAVZEVII|WINE|BEER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79825,"idioma_id":4,"titulo":"EFFECT OF PHENOLIC COMPOUNDS FROM ARGENTINEAN RED WINES ON PATHOGENIC BACTERIA IN A MEAT MODEL SYSTEM","resumen":"In this work, the effectiveness of phenolic compounds of different varieties of wines as antibacterial agent in a meat model system was determined. Total phenolic, flavonoid and flavanol compounds concentrations were greater in Merlot and Malbec wines compared with Cabernet Sauvignon variety. In meat, the best antibacterial effect of wine phenolic compounds against both bacteria was observed with Merlot and Malbec wine varieties at 4 ºC, even when inhibitory effect was also observed at 20 ºC. The lowest decimal reduction time were obtained with Merlot wine for L. monocytogenes and with Malbec and Merlot wines for E. coli. From our results, we propose the use of wine phenolic compounds as natural biopreservatives for meat in combination with low temperatures. These natural products provide the additional human health benefit inherent to polyphenols properties. Key words:&nbsp; Phenolic compounds, wines, L. monocytogenes, E. coli, meat model system, antibacterial effect.","palabras_clave":"PHENOLIC COMPOUNDS|WINES|MEAT MODEL SYSTEM|ANTIBACTERIAL EFFECT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79867,"idioma_id":4,"titulo":"Autonomous phagosomal degradation and antigen presentation in dendritic cells","resumen":"Abstract  Phagocytosis plays a critical role in both innate and adaptive immunity. Phagosomal fusion with late endosomes and lysosomes enhances proteolysis, causing degradation of the phagocytic content. Increased degradation participates in both innate protection against pathogens and the production of antigenic peptides for presentation to T lymphocytes during adaptive immune responses. Specific ligands present in the phagosomal cargo influence the rate of phagosome fusion with lysosomes, thereby modulating both antigen degradation and presentation. Using a combination of cell sorting techniques and single phagosome flow cytometry-based analysis, we found that opsonization with IgG accelerates antigen degradation within individual IgG-containing phagosomes, but not in other phagosomes present in the same cell and devoid of IgG. Likewise, IgG opsonization enhances antigen presentation to CD4(+) T lymphocytes only when antigen and IgG are present within the same phagosome, whereas cells containing phagosomes with either antigen or IgG alone failed to present antigen efficiently. Therefore, individual phagosomes behave autonomously, in terms of both cargo degradation and antigen presentation to CD4(+) T cells. Phagosomal autonomy could serve as a basis for the intracellular discrimination between self and nonself antigens, resulting in the preferential presentation of peptides derived from opsonized, nonself antigens.","palabras_clave":"PHAGOSOME MATURATION|FC RECEPTOR|DENDRITIC CELLS|MHC II-RESTRICTED PRESENTATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":79952,"idioma_id":4,"titulo":"SACRED\/PROFANE: THE DURKHEIMIAN ASPECT OF WILLIAM JAMES'S PHILOSOPHY OF RELIGION","resumen":"Without disregarding the differences between both  perspectives, my hypothesis in this article is that James?s  philosophy of religion has a Durkheimian aspect. As it is  well known, Durkheim considers the distinction between  the sacred and the profane to be the axis of religion. For  James, on the other hand, the core of religion seems to  be the individual relationship with the deity, as  mentioned before. The point of contact between both  conceptions lies in the fact that the Jamesian definition  implies a clear distinction between the sacred and the  profane, which is a prototypically Durkheimian one  which helps to tint the canonical version of a James who  is irremediably imbued with individual Protestantism. In  other words, the sacred\/profane distinction is essential  for James?s philosophy of religion, and this point is best  appreciated in his treatment of morality. Besides, this  distinction is of vital importance to understand the  relationships of James?s philosophy with conservative as  well as with liberal Protestantism.  My argument unfolds in five parts. In the first one  (Durkheim interprets James) I present essential aspects  of the French sociologist?s criticism of the pragmatist; in  the second (Durkheim interprets religion) I characterize  the axis of religion according to Durkheim, that is, the  distinction between the sacred and the profane; in the  third section (James: Durkheimianism and Individualism)  I present some of the essential aspects of James?s  philosophy of religion and I advance my main  hypothesis, namely that there is a Durkheimian aspect in  James?s philosophy of religion; in the fourth section  (James and Durkheim: past, present, and future of  religion) I briefly examine the importance of the  Durkheimian aspect of the Jamesian conception of   religion for its relationship with Protestantism. Finally, I  put forward some conclusions.","palabras_clave":"DURKHEIM|WILLIAM JAMES|PRAGMATISM|RELIGION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80070,"idioma_id":4,"titulo":"Electrochemical regulation of cell polarity and the cytoskeleton.","resumen":"Cell polarity plays a key role in regulating cell-cell communication, tissue architecture, and development. Both internal and external cues participate in directing polarity and feedback onto each other for robust polarization. One poorly appreciated layer of polarity regulation comes from electrochemical signals spatially organized at the level of the cell or the tissue. These signals which include ion fluxes, membrane potential gradients, or even steady electric fields, emerge from the polarized activation of specific ion transporters, and may guide polarity in wound-healing, development or regeneration. How a given electrochemical cue may influence cytoskeletal elements and cell polarity remains unclear. Here, we review recent progress highlighting the role of electrochemical signals in cell and tissue spatial organization, and elucidating the mechanisms for how such signals may regulate cytoskeletal assembly for cell polarity.","palabras_clave":"CELL POLARITY|ELECTRIC FIELDS|S. CEREVISIAE|CITOSKELETON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80076,"idioma_id":5,"titulo":"Una interpretación alternativa acerca de la apropiación originaria en John Locke","resumen":"La versión tradicional respecto del rol del trabajo para la adquisición de la propiedad privada considera que la propiedad se adquiere a través de un inexplicable proceso de mezcla de ?lo poseído? con ?lo no poseído?. El objetivo de este artículo es brindar herramientas conceptuales a fin de elaborar una lectura alternativa. La propiedad privada sólo se considerará legítima si se obtiene mediante el trabajo entendido como una actividad productiva y generadora de valor acorde con los propósitos de Dios. El trabajador es ?hacedor? del objeto a partir de los materiales que Dios le proporciona, similar a un usufructuario. Asimismo es necesario que satisfaga las limitaciones de no-desperdicio y de que haya tanto y de tan buena calidad (para los otros).","palabras_clave":"USUFRUCTO|TRABAJO|PROPIEDAD|PARADOJA DE LA PLENITUD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80079,"idioma_id":5,"titulo":"El Sujeto de Derecho a Reivindicar: La Humanidad. La Dignidad Humana frente al Patentamiento de la Información Genética Humana","resumen":"Una de las implicancias centrales del Proyecto Genoma Humano consistió en la aceleración en el proceso de patentamiento de materia viva en general y del genoma humano en particular, dentro del contexto de desarrollo de la biotecnología y la biomedicina.   Frente a esta situación, la comunidad internacional no ha permanecido indiferente. Se crearon documentos al respecto, entre los cuales se destacan, a saber, la Declaración Universal sobre el Genoma Humano y los Derechos Humanos de la UNESCO, la Convención sobre los Derechos Humanos y la Biomedicina del Consejo de Europa y la Declaración Bioética de Gijón de la Sociedad Internacional de Bioética. Algunos conceptos centrales de la teoría política y jurídica, con gran peso filosófico, se hacen presente en dichos trabajos jurídicos. De este modo, el objetivo del presente trabajo es analizar el concepto de Dignidad Humana en tales textos y su vinculación con el de Humanidad en relación al genoma humano.","palabras_clave":"GENOMA HUMANO|DIGNIDAD HUMANA|HUMANIDAD |PATENTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80082,"idioma_id":5,"titulo":"Intereses en pugna, el rol de Estados Unidos en el Acuerdo ADPIC y el acceso a medicamentos. Las patentes biotecnológicas en perspectiva","resumen":"El presente artículo describe, en primer lugar, el proceso que de manera paulatina amplió el rango de materia patentable en Estados Unidos y desembocó en el otorgamiento de patentes sobre materia viva y sobre la información genética misma. En segundo lugar, analiza la adopción del Acuerdo sobre los ADPIC (Aspectos de los Derechos de Propiedad Intelectual relacionados con el Comercio) por parte de los miembros de la Organización Mundial del Comercio (OMC). Luego, se formulan algunas reflexiones sobre  estas dos cuestiones  a fin de apoyar nuestra hipótesis básica, a saber: que las características de este proceso, que desembocó en el patentamiento de materia viva y de la información genética, hacen suponer que sus consecuencias en cuanto a la problemática y a los desafíos que podrían plantearse en el futuro en relación con el acceso a medicamentos y terapias, serán cuanto menos similares a los que se producen en la actualidad a causa del patentamiento de farmoquímicos.","palabras_clave":"ADPIC|ESTADOS UNIDOS|PATENTES|MATERIA VIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80087,"idioma_id":5,"titulo":"¿Cómo se calculan el tiempo y los costos de desarrollo de un nuevo medicamento? Investigación en ciencias sociales y políticas de protección estricta de derechos de patente","resumen":"Con frecuencia se afirma que el costo de Investigación y Desarrollo de un nuevo medicamento asciende a 802 millones de dólares (año 2000) y que el tiempo necesario para hacerlo ronda entre 10 y 15 años. Esta clase de argumentación ha logrado una expansión tal que se ha instalado en una muiltiplicidad de discursos, incluyendo el académico. Sin embargo, la solidez de las cifras se desmorona cuando se rastrean sus orígenes. El objetivo de este trabajo consiste en analizar dichos números, cuyo origen se remonta al artículo de DiMasi, Hansen &amp; Grabowski (2003) The price of innovation: new estimates of drug development costs realizado en Tufts Center, en el cual se analizaron 68 drogas de una muestra otorgada con carácter confidencial por 10 compañías farmacéuticas multinacionales.    Asimismo, para comprender la influencia de estos datos en el discurso académico y extra-académico, y aún en la defensa de políticas de protección estricta de los derechos de patente, se recurrirá a la teoría de Carol H. Weiss sobre la repercusión de las investigaciones de las ciencias sociales en la toma de decisiones por parte de los funcionarios públicos.","palabras_clave":"PATENTES DE INVENCION|COSTOS DE INVESTIGACION Y DESARROLLO|NUEVAS MEDICINAS|INDUSTRIA FARMACEUTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80124,"idioma_id":5,"titulo":"El capitalismo según Gilles Deleuze: inmanencia y fin de la historia","resumen":"El presente trabajo analiza la concepción del capitalismo de Gilles Deleuze, en el marco de la discusión suscitada por autores que reducen la dimensión política de su obra a una indagación ética. Sostenemos que el pensamiento político deleuziano tiene como punto de partida su abordaje del capitalismo, al cual atribuye dos notas particulares: poner fin a la historia universal y organizar un campo económico de pura inmanencia. Nuestra hipótesis es que la primera característica deriva de la segunda: el capitalismo pone fin a la historia porque funciona de modo inmanente. Con respecto al primer rasgo, ensayamos una comparación con la tesis del período post-histórico presentada por Kojève; con relación al segundo, desarrollamos los tres aspectos de la inmanencia capitalista (axiomática monetaria, límites interiores, expansión de la anti-producción en la producción). Luego, examinamos las dificultades de Deleuze, pese a sus ambiciones revolucionarias, para proponer una salida a la lógica capitalista, así como sus posiciones ambivalentes sobre el alcance de las luchas políticas y el rol de los Estados. Finalmente, sostenemos la pertenencia del pensamiento político deleuziano al horizonte post-revolucionario, en virtud de su rechazo a la consideración histórica de las revoluciones y de su comprensión del capitalismo en clave de inmanencia. ","palabras_clave":"Deleuze|Kojève|capitalismo|inmanencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80127,"idioma_id":5,"titulo":"El problema de la utopía en Gilles Deleuze","resumen":"El presente trabajo aborda la cuestión de la utopía en el pensamiento de Gilles Deleuze. Frente a diversos comentadores que lo consideran un autor utopista (Buchanan, Patton, Scherer, Zourabichvili), argumentamos que su filosofía es inconciliable con la utopía a causa de su opción por el devenir, la fabulación y la creación de lo posible. No obstante, sostenemos que la utopía pone de manifiesto una ambigüedad en la idea deleuzeana de inmanencia. Si bien ésta tiene por efecto rechazar los ideales y las posiciones trascendentes, Deleuze conjuga la inmanencia y la utopía mediante una evaluación inmanente de las acciones guiadas por los ideales utópicos. ","palabras_clave":"DELEUZE|UTOPÍA|POLÍTICA|INMANENCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80157,"idioma_id":5,"titulo":"Itinerario de un experto. Dardo Rietti, el derecho del trabajo y el proceso de construcción de las políticas laborales. Córdoba, 1920-1931","resumen":"Este  artículo analiza las ideas y la trayectoria de Dardo Rietti, reconocido abogado  laboralista que, entre 1900 y 1943, transitó diversas esferas del mundo  académico y el ámbito burocrático de la provincia de Córdoba. Se estudia la  constitución de un perfil profesional vinculado al derecho laboral, analizando la  formación de esta especialidad y su relación con las políticas laborales del  Estado provincial. Además, se examinan los estudios que este especialista elaboró  sobre los problemas del trabajo y las distintas propuestas que formuló para su  resolución.","palabras_clave":"Expertos|Estado|Derecho laboral|Políticas laborales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80368,"idioma_id":4,"titulo":"Fracture and Thermal Behavior of Biomass Ash Polypropylene Composites","resumen":"In this work, the fracture and thermal behaviour of environmentally friendly composites  based on polypropylene (PP), an olefin block copolymer (OBC) and ash from biomass  combustion was investigated. PP\/OBC\/ash composites with different ash contents and  10 wt% OBC were prepared by extrusion followed by compression moulding. Ash  particles were treated with a silane coupling agent before blending to promote interfacial  adhesion between polymer matrix, OBC and ash. An approach to fracture mechanics  was investigated and showed that the fracture parameters increased when OBC was  used. Fracture surface analysis by scanning electron microscope revealed that the  presence of OBC promotes the material ductile failure and that one of the main failure  mechanisms was fibrillised debonding of ash particles encapsulated by OBC from the  matrix and its subsequent elongation around them. Free OBC inclusions distributed  within the PP matrix would have also induced toughening in the composites investigated.  The crystalline state of PP analysed by differential scanning calorimetry is clearly modified  by the presence of ash particles, increasing the crystallisation rate and the crystallinity  degree of the matrix due to the nucleating effect of the filler. However, the presence  of the copolymer counteracted these effects and the PP crystalline state remained  practically unchanged in the composites with OBC. Finally, environmentally friendly  composites with significantly higher toughness than the matrix or binary PP\/ash  composites were obtained by introducing an OBC copolymer in the formulation","palabras_clave":"FRACTURE|THERMAL BEHAVIOUR|POLYMER COMPOSITES|POLYPROPYLENE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80371,"idioma_id":5,"titulo":"Asco y política. reflexiones intempestivas sobre sensibilidades sedimentadas y democracia","resumen":"El presente texto intenta indagar sobre la construcción socio-histórica de sensibilidades conformadas para la reproducción de la desigualdad. Llamamos a este fenómeno \u201CEstéticas del asco y de la higiene\u201D ligadas a virtudes morales. Bajo el capitalismo globalizado, esta apropiación enajenante de emociones y sentimientos motoriza la adhesión a políticas para minorías predispuestas a defender racional y \u201Cafectivamente\u201D el rechazo, exclusión y explotación de las mayorías empobrecidas.","palabras_clave":"DESIGUALDAD|EMOCIONES|ASCO|POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80395,"idioma_id":5,"titulo":"Comunicación y Educación: las transformaciones que nos interpelan TICs y prácticas socioeducativas emergentes a partir de la restitución de lo público.","resumen":"En el presente artículo abordaremos algunos puntos de la perspectiva teórica y algunas preguntas iniciales  respecto de las prácticas socioeducativas que se producen con la incorporación de las denominadas TIC en escuelas, desde una mirada del campo de Comunicación y Educación. A partir de una noción de comunicación como proceso de construcción de sentidos y pensando en una articulación transdisciplinar desde y en las problemáticas del campo antes que por uniones disciplinares forzadas. Las reflexiones que aquí presentamos forman parte de una investigación más amplia que analiza las representaciones de la escuela como espacio público , a partir de la restitución del rol del Estado. Haciendo eje en las políticas públicas que involucran a la comunicación\/ educación en sus diferentes aspectos.","palabras_clave":"Comunicación|Cultura|Educación|Políticas Públicas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80474,"idioma_id":5,"titulo":"Apresentacao del dossier :Novas repúblicas: construção de nações na América Latina do século XIX","resumen":"Introducción al dossier sobre  ?Novas repúblicas: construção de nações na América Latina do século XIX?, también compilado por la autora.","palabras_clave":"REPÚBLICA|AMÉRICA LATINA|SIGLO XIX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80492,"idioma_id":5,"titulo":"La inmigración alemana-brasileña en Misiones, Argentina","resumen":"Este artículo tiene por objeto dar a conocer la historia migratoria del grupo alemán-brasileño en la provincia de Misiones, Argentina, quienes se distinguen por haber desarrollado migraciones transgeneracionales: estuvieron cien años en el sur de Brasil, y ya llevan más de ochenta años en la Argentina. A pesar del largo período fuera del territorio natal y de nuevas migraciones, los descendientes de estos alemanes conservan su idioma, su cultura y sus tradiciones. &nbsp;En primer lugar se analiza cómo el concepto de germaneidad marcó la identidad alemana-brasileña, luego se realiza una periodización de las diferentes etapas migratorias de este grupo, y finalmente sintetiza del proceso colonizador en la colonia Puerto Rico ubicada en el Departamento Libertador General San Martín.","palabras_clave":"Alemanes-brasileños|Inmigración|Colonización|Puerto Rico, Misiones."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80544,"idioma_id":4,"titulo":"A leaf gas exchange model that accounts for intra-canopy","resumen":"Understanding the distribution of gas exchange within a plant is a prerequisite for scaling up from leaves to canopies. We evaluated whether leaf traits were reliable predictors of the effects of leaf ageing and leaf irradiance on leaf photosynthetic capacity (Vcmax, Jmax) in field-grown vines (Vitis vinifera L). Simultaneously,we measured gas exchange, leaf mass per area (LMA) and nitrogen content (Nm) of leaves at different positions within the canopy and at different phenological stages. Daily mean leaf irradiance cumulated over 10 d (PPFD10) was obtained by 3D modelling of the canopy structure. Nm decreased over the season in parallel to leaf ageing while LMA was mainly affected by leaf position. PPFD10 explained 66, 28 and 73% of the variation of LMA, Nm and nitrogen content per area (Na), respectively. Nitrogen content per unit area (Na = LMA ¥ Nm) was the best predictor of the intra-canopy variability of leaf photosynthetic capacity. Finally, we developed a classical photosynthesis-stomatal conductance submodel and by introducing Na as an input, the model accurately simulated the daily pattern of gas exchange for leaves at different positions in the canopy and at different phenological stages during the season.cmax, Jmax) in field-grown vines (Vitis vinifera L). Simultaneously,we measured gas exchange, leaf mass per area (LMA) and nitrogen content (Nm) of leaves at different positions within the canopy and at different phenological stages. Daily mean leaf irradiance cumulated over 10 d (PPFD10) was obtained by 3D modelling of the canopy structure. Nm decreased over the season in parallel to leaf ageing while LMA was mainly affected by leaf position. PPFD10 explained 66, 28 and 73% of the variation of LMA, Nm and nitrogen content per area (Na), respectively. Nitrogen content per unit area (Na = LMA ¥ Nm) was the best predictor of the intra-canopy variability of leaf photosynthetic capacity. Finally, we developed a classical photosynthesis-stomatal conductance submodel and by introducing Na as an input, the model accurately simulated the daily pattern of gas exchange for leaves at different positions in the canopy and at different phenological stages during the season.","palabras_clave":"3D structure|canopy variability|leaf acclimation|light interception"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80612,"idioma_id":5,"titulo":"Ni olvido, ni perdón. Experiencias de memorias frente a la desaparición de personas en Argentina?","resumen":"El objetivo de este trabajo es el análisis histórico,desde una mirada etnográfica, sobre las acciones extrajudiciales en torno a la   construcción de las memorias sobre  la última dictadura militar en  Argentina. Se observan los rituales, prácticas y usos del pasado reciente por diversos actores e instituciones.","palabras_clave":"política|etnografía|rituales|dictadura"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80646,"idioma_id":4,"titulo":"Local convergence of exact and inexact augmented Lagrangian methods under the second-order sufficient optimality condition","resumen":"We establish local convergence and rate of convergence of the classical augmented Lagrangian algorithm under the sole assumption that the dual starting point is close to a multiplier satisfying the second-order sufficient optimality condition. In particular, no constraint qualifications of any kind are needed. Previous literature on the subject required, in addition, the linear independence constraint qualification and either the strict complementarity assumption or a stronger version of the second-order sufficient condition. That said, the classical results allow the initial multiplier estimate to be far from the optimal one, at the expense of proportionally increasing the threshold value for the penalty parameters. Although our primary goal is to avoid constraint qualifications, if the stronger assumptions are introduced, then starting points far from the optimal multiplier are allowed within our analysis as well. Using only the second-order sufficient optimality condition, for penalty parameters large enough we prove primal-dual Q-linear convergence rate, which becomes superlinear if the parameters are allowed to go to infinity. Both exact and inexact solutions of subproblems are considered. In the exact case, we further show that the primal convergence rate is of the same Q-order as the primal-dual rate. Previous assertions for the primal sequence all had to do with the weaker R-rate of convergence and required the stronger assumptions cited above. Finally, we show that under our assumptions one of the popular rules of controlling the penalty parameters ensures their boundedness. &copy; 2012 Society for Industrial and Applied Mathematics.","palabras_clave":"AUGMENTED LAGRANGIAN|METHOD OF MULTIPLIERS|SECOND-ORDER SUFFICIENT OPTIMALITY CONDITION|LINEAR CONVERGENCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80647,"idioma_id":4,"titulo":"The boundedness of penalty parameters in an augmented Lagrangian method with constrained subproblems","resumen":"Augmented Lagrangian methods are effective tools for solving large-scale nonlinear programming problems. At each outer iteration, a minimization subproblem with simple constraints, whose objective function depends on updated Lagrange multipliers and penalty parameters, is approximately solved. When the penalty parameter becomes very large, solving the subproblem becomes difficult; therefore, the effectiveness of this approach is associated with the boundedness of the penalty parameters. In this paper, it is proved that under more natural assumptions than the ones employed until now, penalty parameters are bounded. For proving the new boundedness result, the original algorithm has been slightly modified. Numerical consequences of the modifications are discussed and computational experiments are presented. &copy; 2012 Copyright Taylor and Francis Group, LLC.","palabras_clave":"NONLINEAR PROGRAMMING|AUGMENTED LAGRANGIAN METHODS|PENALTY PARAMETERS|NUMERICAL EXPERIMENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80675,"idioma_id":5,"titulo":"?Las disputas simbólicas en torno al Trabajo en la post-convertibilidad argentina. Mercado de trabajo, ingreso y políticas sociales?","resumen":"El presente escrito realiza un breve análisis de algunas de las transformaciones estructurales ocurridas en la última década, aproximadamente, desde la transición post-crisis 2001, hasta la actualidad. A tal fin, reconstruye algunas tendencias en cuanto al desempleo, el subempleo, la pobreza, la informalidad y la precariedad, el salario real, la distribución del ingreso, etc., en el mercado de trabajo en el contexto actual. Luego, analiza algunas transformaciones en la orientación de las políticas sociales y de empleo, fundamentalmente en lo que parte de la bibliografía identifica como un giro hacia la universalización y el ?inclusionismo?. El texto se orienta a establecer algunas líneas de análisis para aportar a la definición del actual contexto de post-convertibilidad en tanto condiciones estructurales que sirven para la comprensión tanto de las estrategias de reproducción habilitadas para los sectores populares, como así también, las disputas simbólicas que a su interior y exterior se establecen a partir de estas nuevas condiciones.","palabras_clave":"mercado de trabajo|clases sociales|postconvertibilidad|disputas simbólicas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":80787,"idioma_id":7,"titulo":"Rodolfo Mondolfo: La infinitudine dello spirito e altri scritti di Córdoba","resumen":"Si fa la recenzione del volume La infinitud del espíritu y otros escritos de Córdoba di Rodolfo Mondolfo publicato dalla Universidad Nacional de Córdoba (Argentina) dei anni in cui lo storico della filosofia greca, nel essilio, insegnava in quella sede academica. Si fa una valutazione dei scritti quali contributi alla Storia della filosofia (antica, moderna, contemporanea) e alla cultura filosofica del paese sudamericano. Per ultimo, si fa una recensione dei testi raccolti nel volume.","palabras_clave":"Escepticismo|Historia de la filosofía|Materialismo|Antigüedad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81011,"idioma_id":5,"titulo":"Acerca del principio constructivo en la teoría del conocimiento de Walter Benjamin?","resumen":"El objetivo que orienta este trabajo es abordar la noción de construcción presente en la obra de Walter Benjamin, en su peculiar posición materialista, de modo tal de complejizar un concepto ligado a producciones teóricas que, más o menos conscientemente, destacan sólo su costado armónico, sin considerar la dimensión destructiva, de detención e interrupción, sobre la cual tan genialmente este pensador ha echado luz. Se trata de cuestionar, con las herramientas brindadas por Benjamin, una concepción epistemológica  y política- centrada en la interpretación del conocimiento como aquello que se revela en el sujeto, resultando ser éste quien constituye lo real, crea el contexto y las coordenadas a partir de las cuales sus descripciones tendrán sentido. Asumiendo que la crítica social y política no es algo que pueda hacerse desde el conocimiento vigente es que nos adentramos en el análisis de uno de los aspectos de la vasta producción benjaminiana dedicada a la teoría del conocimiento.","palabras_clave":"MATERIALISMO|CONSTRUCTIVISMO|CONOCIMIENTO|CONSTRUCCIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81185,"idioma_id":5,"titulo":"Reseña del XI Simposio de Investigación en Enseñanza de la Física.","resumen":"Reseña del XI Simposio de Investigación en Enseñanza de la Física.  26 al 28 de octubre de 2012. Esquel (Chubut).","palabras_clave":"RESEÑA|IX SIMPOSIO|INVESTIGACIÓN EN ENSEÑANZA|ENSEÑANZA DE LA FÍSICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81189,"idioma_id":5,"titulo":"Reseña de las III Jornadas de Enseñanza e Investigación Educativa en el campo de las Ciencias Exactas y Naturales. Facultad de Humanidades y Ciencias de la Educación.","resumen":"Reseña de las III Jornadas de Enseñanza e Investigación Educativa en el campo de las Ciencias Exactas y Naturales. Facultad de Humanidades y Ciencias de la Educación. Universidad Nacional de La Plata.  26 al 28 de septiembre de 2012.","palabras_clave":"RESEÑA|ENSEÑANZA E INVESTIGACIÓN EDUCATIVA |CAMPO DE LAS CIENCIAS EXACTAS Y NATURALES|JORNADAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81224,"idioma_id":5,"titulo":"El análisis de las exportaciones de maquinaria agrícola argentina como expresión de su competitividad (1960-1976)","resumen":"La mayoría de los estudios sobre la industria argentina, incluso los sectoriales, se limitaron a analizar su desarrollo en el plano interno. En ese sentido, pierden de vista la evolución internacional de las diferentes ramas de producción, fundamentales para comprender el devenir local y para entender contra quiénes y en qué condiciones debía competir la industria argentina.  Por ello, en este trabajo analizamos la competitividad internacional de la maquinaria agrícola argentina entre 1960 y 1976 con potencialidad exportadora para varios autores, a partir de los elementos que determinaron la acumulación de capital en la rama. Estudiamos las características del mercado interno y de la producción local. Con ese acervo, indagamos sobre la cuestión de las exportaciones, estudiando el destino de los envíos y la participación relativa de la Argentina en esas plazas. Esto nos permitirá discutir con la idea de una tendencia exportadora del sector.","palabras_clave":"MAQUINARIA AGRICOLA|ARGENTINA|MERCADO|EXPORTACIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81255,"idioma_id":5,"titulo":"REVISION DE LIBROS: Carnivores of the World","resumen":"Se realiza una revision del libro 'Carnivores of the World' escrito por Luke Hunter, 2011. Princeton University Press, Princeton y Oxford, 240 pp.","palabras_clave":"carnivoros"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81285,"idioma_id":4,"titulo":"Towards global patterns in the diversity and community structure of ectomycorrhizal fungi","resumen":"Global species richness patterns of soil micro-organisms remain poorly understood  compared to macro-organisms. We use a global analysis to disentangle the global  determinants of diversity and community composition for ectomycorrhizal (EcM)  fungi?microbial symbionts that play key roles in plant nutrition in most temperate  and many tropical forest ecosystems. Host plant family has the strongest effect on the  phylogenetic community composition of fungi, whereas temperature and precipitation  mostly affect EcM fungal richness that peaks in the temperate and boreal forest biomes,  contrasting with latitudinal patterns of macro-organisms. Tropical ecosystems experience  rapid turnover of organic material and have weak soil stratification, suggesting that poor  habitat conditions may contribute to the relatively low richness of EcM fungi, and  perhaps other soil biota, in most tropical ecosystems. For EcM fungi, greater evolutionary  age and larger total area of EcM host vegetation may also contribute to the higher  diversity in temperate ecosystems. Our results provide useful biogeographic and  ecological hypotheses for explaining the distribution of fungi that remain to be tested  by involving next-generation sequencing techniques and relevant soil metadata.","palabras_clave":"global analysis|latitudinal gradient of diversity|macro-ecology|soil microbes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81324,"idioma_id":5,"titulo":"Una aproximación a los caminos del reconocimiento","resumen":"El artículo es un comentario del libro de Paul Ricoeur 'Caminos del reconocimiento. Tres estudios'. Se realiza una aproximación a los distintos sentidos en los que el autor trabaja la categoría de reconocimiento en su escrito.","palabras_clave":"RECONOCIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81327,"idioma_id":5,"titulo":"La politicas culturales en la cultura politica","resumen":"El artículo aporta datos sobre la inversión en cultura y trabaja la   relación entre la cultura y la política, aprovechando la discusión   sucedida en la apertura de la Feria del Libro en la Ciudad Autónoma de   Buenos Aires del año 2012.","palabras_clave":"Políticas cutlurales|Industrias Culturales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81341,"idioma_id":4,"titulo":"Systemic Exposure, Tissue Distribution, and Disease Evolution of a High Solubility Ciprofloxacin?Aluminum Complex in a Murine Model of Septicemia Induced by Salmonella enterica Serotype Enteritidis","resumen":"A new pharmaceutical derivative obtained by stoichiometric complexation of ciprofloxacin (CIP) with aluminum (CIP-complex) has been investigated and reported in this study. Such product has high solubility in the gastrointestinal pH range and was successful in the development of optimized formulations while maintaining its antimicrobial potency. The systemic exposure, tissue distribution, and the disease evolution after given CIP-complex were assessed. The systemic exposure and distribution in intestines, lungs, and kidneys after a single intragastric administration of CIP-complex and CIP given alone, used as reference, were performed in Balb-C mice at a dose of 5 mg CIP\/kg. For the assessment of the disease evolution assay, mice were infected with a virulent strain of Salmonella enterica serotype Enteritidis and treated intragastrically once or twice daily during 5 consecutive days with solutions of CIP-complex or the reference. Clinical follow up and survival was measured during 15 days post inoculation and health state was scored during this period from 0 to 5. CIP-complex showed a 32% increase in Cmax, an earlier Tmax, and a smaller AUC0&#8722;12 than the reference. Maximum tissue concentrations (0.5&#8722;1 h) were significantly higher in CIP-complex (447% in intestine, 93% in kidney, and 44% in lungs). In the infection model used in this study, survival in CIP-complex versus CIP groups was 40% versus 20% (twice-daily administration) and 30% versus 0% (once-daily administration). Health state of the survivors of CIP-complex group (5\/5) was higher than CIP group (3\/5). The greater effectiveness of CIP-complex is attributed to the higher levels of CIP in the intestine. Our results supported the fact that CIP-complex is a promising candidate to develop dose-efficient formulations of CIP for oral administration.","palabras_clave":"fluoroquinolone complexes|infection model|pharmacokinetics\/Pharmacodynamics|biopharmaceutic classification system"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81362,"idioma_id":4,"titulo":"Evaluation of some critical points of the asparagus food chain in Argentina.","resumen":"In order to contribute to optimize, quantitatively as well as qualitatively, the productivity of this species in Argentina, and to generate its expansion, trials with 68 plots and a total area of 3021m2 were carried out in the Experimental Unit, F.A.A.-UNCPBA (36°48´ South Lat. and 59°51´ West Long.). The aim was to analyze the impact on the productive yield of some critical points corresponding to the initial stage of the crop, evaluating the productivity with different male Italian hybrids (HMI): (Italo, Zeno, Eros, Ercole, H668, Marte, Giove, and American control UC157); two densities (D1:25,000 and D2:17,857 pl.ha-1);  initiation systems (STA: Traditional System of Crowns and SMP: Modern System of Seedlings) and sizes of initiation organs: G: big, M:medium and CH: small. In STA: G: >150g; M:100?150g and Ch:<100g; and SMP: G:40, M:60 and CH:80cm3 of cell respectively.  The variables studied were total and net productivity (top quality) in t.ha-1 (PFT and PFN), number of turions (NT), distribution of calibers (J,XL,L,M,S), average weight of turions (PPT) and %  of discard. In all the cases, PTF and PFN followed a similar trend. The average hybrid was 9.2. In PFT, T surpassed HMI; UC157:11(a); Zeno:10.6(ab); Ercole:9.7(bc); Eros:9.3(c); H668:9.3(c); Giove:8(d); Italo:8.2(d) and Marte:7.7(e); differences were found in the length of turions, homogeneity, precocity and % of discard. In PPT, HMI surpassed T, producing turions with bracts more resistant to opening, lower % of discard, with the exception of Zeno. In D1, 15.4(a) were obtained and D2:13.9(b); whereas in NT there were no significant differences. In STA, the PFT was G: 17.2 (a); M:14.8(b) and CH:11.9 (c), whereas with SMP no significant differences were observed. These results show that Argentina has a high productive potential if the necessary adjustments are performed in the most critical links of the chain when planning a crop.","palabras_clave":"PRODUCTION|QUALITY|TURIONS|DENSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81367,"idioma_id":4,"titulo":"First Fruit Production of hybrid asparagus in Argentina","resumen":"Market globalization and present competitiveness degree of productions with high added value as asparagus require product standardization, the availability of high productivity hybrids with quality according to consumers? demands and the extension of the offer calendar trying to anticipate the positioning of the product in the market with respect to field productions. The use of semi-forced protections such as cold greenhouses is a valuable alternative for the production of green asparagus first fruits; however, it is necessary to determine the adaptation of the hybrids in the market. In order to study the behaviour of eight asparagus hybrids for the production of first fruits, a trial was carried out (15\/11\/2006), in a semicircular greenhouse using masculine Italian hybrids I) Italo, II) Zeno, III) Eros, IV) Ercole, V) H668, VI) Marte, VII) Giove and as control (T) UC157 (American); with 100-day seedlings at 0.30×1 m. A multivaried model was run. Net weight ha-1 (PBTH) and net of 1ª\/ha and 2ª\/ha (PNTH1ª and PNTH2ª); number of turions (NT) and turion average weight (PPT) were the variables considered. For PBTH, PN1ª and NT, significant differences were detected among hybrids. In PBT (kg ha-1), T was greater (8375(c)), followed by II) 6862; VII) 6147; I) 5760 and III) 5836(bc); V) 4510(b); IV) 3917(ab) and VI) 1522(a). In PN1o, the tendency was similar: T: 3401,7(c); VII) 2080.5(b); III) 2000.7; I) 1900; II) 1683.3(ab); V) 1455.8; IV) 1402(b) and finally VI) 226.7(a). The PNTH for both qualities followed a similar pattern. Concerning PPT (g t-1), most of the Italian hybrids surpassed T: 11, VII) 17, II) 15; IV) 14 and I) 14 g turion-1 respectively. Although the differences found in PBTH show a better general adaptation of T, analyzing PNTH, PPT and the lower discard of some Italian hybrids, it can be said that the use of ?Giove?, ?Italo? and ?Eros? is promising.","palabras_clave":"PRODUCCIÓN|CALIDAD|TURIONES|INVERNADERO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81371,"idioma_id":4,"titulo":"Comparing silvopastoral systems and prospects in eight regions of the world.","resumen":"Silvopasture systems combine trees, forage, and livestock in a variety of different species and management regimes, depending on the biophysical, economic, cultural, and market factors in a region. We describe and compare actual farm practices and current research trials of silvopastoral systems in eight regions within seven countries of the world: Misiones and Corrientes provinces, Argentina; La Pampa province, Argentina; northwestern Minas Gerais, Brazil; the Aysén region of Patagonia, Chile; the North Island of New Zealand; the Southeast United States; Paraguay; and Uruguay. Some countries use native trees and existing forests; some use plantations, particularly of exotic species. Natural forest silvopasture systems generally add livestock in extensive systems, to capture the benefits of shade, forage, and income diversification without much added inputs. Plantation forest systems are more purposive and intensive, with more focus on joint production and profits, for small owners, large ranches, and timber companies. Trends suggest that more active management of both natural and planted silvopastoral systems will be required to enhance joint production of timber and livestock, achieve income diversification and reduce financial risk, make more profit, improve environmental benefits, and realize more resilience to adapt to climate change.","palabras_clave":"AGROFORESTRY|GRAZING|PRODUCTION VALUE|SUSTAINABILITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81411,"idioma_id":5,"titulo":"Caracterización Macroscópica y Microscópica de las Glándulas Anexas del Aparato Reproductor Masculino de la LLama (Lama glama)","resumen":"Se caracterizó la estructura macroscópica y microscópica de las glándulas sexuales anexas del tracto reproductor de la llama macho empleando ocho animales adultos. Se hizo el estudio macroscópico in situ y de órganos aislados, y se colectaron muestras de los órganos para la evaluación histológica. El estudio macroscópico reveló la presencia de dos ampollas en el conducto deferente, ausencia de glándulas seminales, próstata con cuerpo lobulado, istmo y porción diseminada, y dos glándulas bulbouretrales. La dilatación de la porción final de los conductos deferentes sugiere la presencia de las ampollas con característica glandular. El cuerpo prostático tiene apariencia lobular aunque sin una clara delimitación de los lóbulos, y presenta prolongaciones hacia la uretra en forma de pedúnculos, claramente delimitados en la porción diseminada. El peso y las medidas de los lóbulos prostáticos indican que hay mayor masa glandular en el lóbulo izquierdo. Los acinos prostáticos están rodeados de abundante tejido conectivo infiltrado a manera de trabéculas a partir del tejido de la cápsula. Los conductos prostáticos tienen diferentes presentaciones en su desembocadura. Las dos glándulas bulbouretrales son simétricas en peso y tamaño, y están rodeadas de abundante tejido muscular esquelético y poca infiltración de conectivo. Los conductos de las glándulas bulbouretrales desembocan enun divertículo que está dirigido hacia la porción libre del pene. Se concluye que la llama macho presenta ciertas particularidades macroscópicas y microscópicas en relación a la distribución y desembocadura de sus glándulas sexuales anexas.","palabras_clave":"LLAMA|MACHO|GLÁNDULAS|ANATOMÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81448,"idioma_id":4,"titulo":"Vip3C, a Novel Class of Vegetative Insecticidal Proteins from Bacillus thuringiensis","resumen":"Three vip3 genes were identified in two Bacillus thuringiensis Spanish collections. Sequence analysis revealed a novel Vip3 protein  class (Vip3C). Preliminary bioassays of larvae from 10 different lepidopteran species indicated that Vip3Ca3 caused more  than 70% mortality in four species after 10 days at 4 g\/cm2.","palabras_clave":"BACILLUS THURINGIENSIS|VEGETATIVE INSECTICIDAL PROTEINS|LEPIDOPTERAN PESTS|BIOLOGICAL CONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81474,"idioma_id":5,"titulo":"Franco Ferrari: de la apropiación al plagio en un solo click","resumen":"    Plagio y  apropiación, robo y resignificación, son los dos polos entre los que oscila la  obra de Franco Ferrari. Sutiles diferencias terminológicas que evitaron que los  artistas apropiacionistas vayan a la cárcel. En los ochenta Mike Bidlo y  Sherrie Levine exhibieron Not Warhol y  After Piet Mondrian, obras que no incurrían  en el plagio sino que exponían un nuevo original, exactamente igual al anterior  pero recontextualizado y resignificado.    La obra de  Ferrari instala la reflexión sobre los conceptos de copia, plagio y apropiación  a la vez que permite a la sociedad entera vincularse con las grandes obras  maestras. Sus obras site-specific  proponen cambiar las reglas de la museología generando en cualquier ámbito  edilicio un contacto entre el arte culto, lo masivo y lo políticamente  incorrecto.   ","palabras_clave":"FRANCO|FERRARI|APROPIACIÓN|PLAGIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81523,"idioma_id":5,"titulo":"El Fideicomiso en el Proyecto de Código Civil y Comercial de la Nación 2012","resumen":"Se comenta la regulación del Fideicomiso en el Proyecto de CCC","palabras_clave":"FIDEICOMISO|REFORMAS LEGISLATIVAS|NUEVO CÓDIGO CIVIL Y COMERCIAL|DERECHO COMERCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81535,"idioma_id":4,"titulo":"Recognising strategies for conquered territories: a case study from the Inka North Calchaqui Valley","resumen":"In this detailed study of fifteenth-century settlements in Argentina, the authors show how the Inka did not just use force, production and ritual to subdue the indigenous population. The conquerors? strategy included the re-ordering of settlement plans, routeways and landscape, class separation and even the imposition of a rigorous discipline on the indigenous vision, controlling what could be seen looking out or looking in.   The material readings made in these South American examples have much to offer to archaeologists working in colonial periods elsewhere.","palabras_clave":"INKA|FIFTEENTH CENTURY|COLONIALISM|PATHWAYS\/VIEWSHEDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81581,"idioma_id":5,"titulo":"Piptocarpha angustifolia (Vernoniae: Asteraceae), nueva cita para la flora argentina. Boletín de la Sociedad Argentina de Botánica 47(3-4): 5p.","resumen":"El género Piptocarpha R.Br. (Vernonieae, Asteraceae) posee 46 especies distribuidas ampliamente desde Centroamérica hasta Argentina. Las especies son arbustos apoyantes o raramente árboles, con inflorescencias axilares formadas generalmente por glomérulos globosos. Para nuestro país solamente se ha citado a P. sellowii (Sch.Bip.) Baker var. balansiana Hieron. como único representante del género. En el presente trabajo se cita por primera vez para Argentina a P. angustifolia Dusén ex Malme, que se diferencia de la otra especie de Piptocarpha por tener hábito arbóreo y glomérulos con menor número de capítulos, entre otros caracteres.","palabras_clave":"Nuevo registro|Misiones|Árbol|Asteraceae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81589,"idioma_id":5,"titulo":"Religión y estado moderno: una tensión inacabable. A propósito del diálogo Habermas-Ratzinger","resumen":"El presente escrito ofrece un estudio comparativo de las posiciones irreductibles de Habermas y Ratzinger frente a dos cuestiones, cuales son: la posibilidad que el estado moderno sea garante de la libertad, careciendo de todo valor que preceda a esa libertad, y la presencia de la religión en la configuración de la política.  Habermas responde a las referidas cuestiones desde su teoría de la acción comunicativa, la cual hunde sus raíces en un racionalismo post-metafísico. Ratzinger, por su parte, concibe al estado moderno a partir de un fundamento metafísico que otorga sustento a la libertad y a los derechos humanos.","palabras_clave":"HABERMAS|RATZINGER|ESTADO|RELIGIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81592,"idioma_id":5,"titulo":"EDUCACIÓN, LAICISMO AGGIORNADO E IGLESIA CATÓLICA","resumen":"El artículo se refiere, en un primer momento, a la nueva versión habermasiana del laicismo y su traducción en el ámbito de la educación. Se muestra la filiación racionalista de esta versión aggiornada del laicismo y la contradicción que anida en el mismo punto de partida del propio racionalismo: su fundación no en una razón sino en una decisión.  De esta realidad se desprende la necesidad del racionalismo de ejercer un férreo control sobre el pensamiento, prohibiendo que el pensar se interrogue por las cuestiones últimas. Así la escuela, producto de este laicismo, es una escuela absorbida totalmente por las cuestiones inmediatas, lo cual priva al hombre de una auténtica cultura.  En un segundo momento, el trabajo pone de manifiesto la impotencia que anida en la conciencia actual del católico para volver a poner en relación al hombre de hoy con las cuestiones últimas.","palabras_clave":"RACIONALISMO|NUEVO LAICISMO|ESCUELA|TOTALITARISMO DE LAS PREGUNTAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81596,"idioma_id":5,"titulo":"EL ONTOLOGISMO EN AUGUSTO DEL NOCE","resumen":"A partir de una crítica a la idea de la modernidad (la cual, forjada por pensadores iluministas, influyó fuertemente en parte del pensamiento católico), Augusto Del Noce explora, en el propio tiempo moderno, una línea metafísica cristiana denominada ontologista, la cual representa una continuidad del pensamiento metafísico cristiano tanto de San Agustín como de Santo Tomás de Aquino.  Del Noce, en tanto historiador, valora de modo especial la instancia de la continuidad. Es a partir de esta idea, y no de la de ruptura, que elabora su propia visión de la modernidad.   Es a partir de esta idea, y no de la de ruptura, que elabora su propia visión de la modernidad.  La visión no axiológica de la modernidad, propia de Del Noce, en contraposición a la axiológica propia de la versión canónica y hegemónica, lo conducirá a precisar la verdadera naturaleza del ontologismo cristiano moderno. Esto, a su vez, le permitirá trazar, desde una dialéctica interna entre una versión racionalista y otra religiosa, el cuadro hermenéutico en el cual situará la reconstrucción historiográfica operada tanto en Il problema dell?ateismo como así también en el volumen del año siguiente, Riforma cattolica e filosofía moderna.","palabras_clave":"AUGUSTO DEL NOCE|MODERNIDAD|CONTINUIDAD|ONTOLOGISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81599,"idioma_id":5,"titulo":"La política cristiana como ?pesimismo liberal? en Augusto Del Noce","resumen":"El presente artículo da cuenta de lo que debiera ser, para Del Noce, el diseño de una concepción cristiana de la política para los tiempos modernos.  La tesis delnociana descansa sobre dos supuestos: el primero es que toda propuesta de una política cristiana no puede desconocer la situación espiritual del hombre al que se le formula; el segundo es que la misma, además de los principios invariables que seguramente la sustentan, deberá poseer elementos contingentes en su configuración.  Fundado en estos supuestos, Del Noce declara inviable el ideal teocrático y asume una política cristiana a la que califica como pesimismo liberal.","palabras_clave":"POLÍTICA CRISTIANA|TEOCRACIA|PECADO ORIGINAL|PESIMISMO LIBERAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81615,"idioma_id":5,"titulo":"MACS: HERRAMIENTA PARA LA GESTIÓN DE CONEXIONES ASPECTUALES","resumen":"Las reglas de negocio son elementos atómicos que componen el marco estructural, la política,la estrategia y la operatividad de una empresa u organización. Es decir que reflejan las políticas de negocio, que tienen como finalidad alcanzar los objetivos del negocio, satisfacer a los clientes,hacer un buen uso de los recursos, y respetar las leyes o convenciones de la empresa u organización [1]. Pueden encontrarse en todo tipo de aplicaciones tales como finanzas y seguros, negocios electrónicos, transportes, servicios basados en Web y personalización; telecomunicaciones entre otros. Las reglas de negocio son dinámicas, están sujetas a cambios en el tiempo. Estos cambios constantes exigen que la implementación de la regla de negocio este separada de la lógica central del negocio para responder a este entorno dinámico. Las principales estrategias de implementación de reglas de negocio, Patrones de Diseño [2] y Sistemas Manejadores de Reglas de Negocio [3], se abocan a hacer las reglas explícitas y separadas de la funcionalidad central. Esto permite la separación de las reglas del dominio, sin embargo, este tipo de implementación requiere código que conecte e integre a la regla de negocios de la funcionalidad central. En consecuencia se producen inconvenientes para la reutilización y mantenimiento de estos componentes bases, además de convertir al dominio en volátil, dado que un simple cambio en la interfaz con la regla implica modificaciones en el código de la conexión...","palabras_clave":"Reglas de Negocio|AOP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81620,"idioma_id":5,"titulo":"Análisis de género y estudios sobre profesiones: propuestas y desafíos de un diálogo posible -y alentador-","resumen":"El artículo propone líneas de diálogo entre dos campos de estudio: los estudios de género y los estudios sobre profesiones. Partiendo de la base que algunos de los autores más destacados de la sociología de las profesiones en la actualidad no trabajan la dimensión de género y que los estudios de género se han preocupado hasta ahora por cuestiones consideradas más urgentes por los feminismos tanto académicos como políticos, el artículo propone algunos ejes que podrían articular dicho diálogo. Así, desde las teorías del currículum oculto de género, hasta la idea de 'vocación' trabajada por Bourdieu, se proponen diversas líneas de diálogo con el fin de estimular estudios concretos.","palabras_clave":"GENERO|PROFESIONES|SOCIOLOGÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81666,"idioma_id":5,"titulo":"Las últimas décadas en América Latina: de la Reforma a la Refundación del Estado","resumen":"El presente artículo es una aproximación a los cambios que los estados de América Latina han experimentado en las últimas décadas.   Desde la Reforma del Estado neoliberal de fines del siglo XX, en nuestra región se inició un periodo de trasformaciones en las instituciones estatales y en sus relaciones con la sociedad civil. El Estado capitalista fue activo partícipe de una redefinición del espacio público que tendió a ensanchar el mercado y que culminó en una gran crisis económica, social y política, que atravesó, casi sin excepciones, a todos los países latinoamericanos.  Desde los primeros años del siglo XX esa gran crisis fue sucedida por una nueva época caracterizada por el surgimiento de movimientos sociales que se convierten en actores políticos relevantes, reformas en las instituciones del Estado, novedosos mecanismos de participación, reconocimiento de derechos de naciones originarias y modificaciones profundas en la relación Estado y Sociedad plasmadas en las constituciones.   Se trata de fenómenos diversos en varios países. Desde políticas públicas desarrollistas con reivindicaciones nacional populares, hasta fuerzas sociales que impulsan una profunda 'Refundación del Estado', se abre un abanico original e inédito en el que la teoría del Estado y la teoría de la democracia encuentran un capítulo propiamente latinoamericano.   El debate está abierto: ¿Finalizó realmente la etapa neoliberal? ¿Es pertinente hablar de posneoliberalismo? ¿La democracia representativa comienza a conjugarse con la democracia participativa y la democracia comunitaria? ¿Cuáles son los límites y las dificultades que enfrenta el proceso de Refundación del Estado?  En el presente artículo se presenta una breve teoría del Estado capitalista (Capítulo 2) que permite introducirse en el conocimiento de ese Estado, el cual vivió en las últimos años del siglo XX un proceso al que se denominó Reforma (Capítulo 3) y que hoy transita por una nueva metamorfosis, quizá más profunda y que todavía está definiendo sus caracteres básicos, y cuyos actores principales suelen llamar Refundación (Capítulo 4).","palabras_clave":"LATINOAMÉRICA|ESTADO|REFORMA|REFUNDACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81704,"idioma_id":4,"titulo":"When fuel cells fly","resumen":"Environmental sustainability should gain a significant role as one of the main drivers in the design of new generation of transport civil aircrafts in order to obtain more\/all electric aircrafts powered by greener energy sources as hydrogen fuel cell systems. In this framework, the European Commission has selected ENFICA-FC (ENvironmentally Friendly Inter City Aircraft powered by Fuel Cells), as one of the co-founded projects in the Aeronautics and Space 6th Framework Programme. The goals of the project were the following: 1) A feasibility study in order to provide a preliminary definition of new and innovative power systems based on different fuel cell technologies; 2) The conversion of a modern and conventional two-seat aircraft into an all-electric airplane entirely powered by fuel cell.  A feasibility study was carried out to provide a preliminary definition of   systems (APU, primary electrical generation supply, emergency electrical power supply, landing gear, de-icing system, etc) in which fuel cells (PEM or SOFC) can be exploited. The feasibility study took into account the both present technologies and expected improvements of future generation of fuel-cell systems and thereby showed the differences in aircraft performances that could arise between conventional and more\/all electric aircraft for different levels of technology development. In addition, the feasibility of an all-electric propulsion inter-city aircraft (10-15 seat), completely powered by fuel cells, was studied in order to assess the impact that could have a more silent and less polluting aircraft. The second part of the paper deals with the setting up and test flights of a fuel cell general aviation aircraft fuelled by hydrogen. The all-electrical power system was successfully tested during the experimental flights. A new speed world record of 135 km\/h and an endurance of 39 min. were established during several flights conducted for the FAI Sporting Code Category C (airplane). 2.5 hours of effective flight were obtained during these 6 tests for a total path of 237 km. The positive handling qualities and satisfactory engine performances of these six flight tests have led the team to consider these successful flights as a good starting point for further long endurance high speed flights.","palabras_clave":"Hydrogen|Aircraft|Experimental test|Zero Emission Vehicle"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81707,"idioma_id":4,"titulo":"Design and testing of a propeller for a two-seater aircraft powered by fuel cells","resumen":"The paper deals with the design, manufacturing and testing of a propeller for a general aviation aircraft fuelled by hydrogen. The feasibility of the ENFICA-FC project depended on several key-enabling technologies. In order to minimize the power required from both the batteries and the fuel cell, a highly efficient electrical propulsion system was required, in which all the components would need to yield the highest possible efficiency. The choice of the propeller for this specific aircraft was more difficult, above all because the electric motor was limited as to the torque it could handle. In addition, the propeller would also have to provide the necessary airflow for the motor, electronics and fuel cell cooling to ensure that the temperature did not exceed the limits imposed by the manufacturer. Although a designer may be aided by modern numerical design and analysis programmes to optimize propellers, structural and manufacturing constraints can influence the final choices. Finally, the calculated performance would always have to be validated with experimental tests. An optimal propeller has been designed and manufactured to be installed on the  Rapid 200 FC aeroplane. Static tests on the manufactured two-blade propeller were performed by means of a static test facility.  Specific tests have also been performed to check the efficiency of the propeller when installation effects (blockage and scrubbing drag effects) are included and to verify the real efficiency of the propulsion and cooling systems, with the propeller installed in the complete converted aircraft. A good agreement between the theoretical and experimental data was obtained.","palabras_clave":"Fuel Cell Aircraft|CFD Analysis,|propeller design"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81789,"idioma_id":5,"titulo":"El derecho penal del 'peligroso': medidas de seguridad y regímenes de excepción. Una lectura etnográfica.","resumen":"El artículo argumenta sobre la posibilidad de pensar al 'sistema de medidas de seguridad curativas para inimputables' como régimen de excepción. En primer lugar, aportando reflexiones en torno al corpus normativo que lo reglamenta, que es abordado en términos de 'legislación preventiva' orientada al castigo de la potencialidad de cometer un delito. Luego indagando en relación a la administración judicial del sistema de medidas de seguridad, en particular sobre cómo se construyen 'sujetos inimputables' susceptibles de tales medidas. Finalmente, aportando datos sobre el desarrollo de las medidas en el ámbito penitenciario que incluyen en muchos casos, prácticas de aislamiento radical, privación sensorial, suspensión de todas las garantías aseguradas por el régimen progresivo de la pena y tratamiento psicológico?psiquiátrico con administración de medicamentos. Desde esta perspectiva y a fin de dar cuerpo a las argumentaciones presentadas, el artículo ofrece el abordaje de un caso judicial en particular, en el cual se discute la posibilidad de la declaración de inimputabilidad y el levantamiento de una medida de seguridad curativa en la instancia de instrucción; aun cuando la materialidad del hecho no fue siquiera discutida y el derecho a la legítima defensa no pudo ser desarrollado.","palabras_clave":"dispositivos penales|inimputabilidad|medidas de seguridad|regímenes de excepción"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81817,"idioma_id":5,"titulo":"«Juventudes, delincuencia y castigo». Un estudio de caso en noticieros de televisión","resumen":"Las percepciones de riesgo en materia securitaria se asocian frecuentemente con actividades delictivas que amenazan los bienes y la vida de ciudadanos y ciudadanas ubicados\/as en la posición de víctimas. A partir de la escenificación de noticias sobre micro-delitos, los relatos periodísticos amplifican el miedo urbano en un espiral de discursos victimizantes que legitiman la necesidad de mayor 'efectividad' en políticas de prevención y castigo. El problema de la falta de seguridad no deviene novedoso. Constituye más bien un tema central de la agenda pública que irrumpe, se mantiene y declina en coyunturas históricas diversas, de acuerdo con las disputas libradas en el campo político, económico, policial, judicial (y mediático). El accionar periodístico funciona de modo semejante al sistema penal: la selectividad de prácticas y valores naturalizados como producto y efecto del Derecho se expresa en la exclusión, inclusión y jerarquización de información periodística. La presión ejercida en estos juegos de poder, forja y habilita el consentimiento de prácticas punitivas hacia sujetos expulsados de un orden social desigual.","palabras_clave":"JUVENTUDES|DELINCUENCIA|CASTIGO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81819,"idioma_id":5,"titulo":"Representaciones del perfil de jóvenes transgresores de la ley penal en un programa de radio difusión","resumen":"El presente trabajo pretende dar cuenta de las retóricas periodísticas que construyen la imagen del «joven delincuente» en el programa de radiodifusión 'Inocentes y Culpables', transmitido por la emisora Mitre\/ AM 790, los sábados de 13.00 a 15.00. La investigación analiza la atribución de estereotipos hacia las juventudes a partir de un caso de discriminación en los medios masivos. Para ello, se examinan tres cuestiones principales: 1) el rol de los conductores\/as del programa radial; 2) los mecanismos de estigmatización en la representación de la identidad de delincuente; 3) el papel de las fuentes informativas en la construcción de noticias. La metodología de estudio emplea una perspectiva sincrónica, desde donde se emprende un análisis de contenido del programa, del 17\/07\/10. La finalidad de la exploración es reflexionar sobre los modos de abordar la cuestión criminal juvenil a partir de un conjunto de operaciones estigmatizantes que legitiman la exclusión de jóvenes en los relatos periodísticos.","palabras_clave":"JÓVENES|CRIMINALIZACIÓN|RADIODIFUSIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81821,"idioma_id":5,"titulo":"«Justicia para Santiago». Un estudio sobre la criminalización de jóvenes en noticieros de televisión","resumen":"El objetivo de este trabajo es examinar las formas en que los discursos periodísticos de los telediarios construyeron el caso Urbani, un robo que desencadenó la muerte de un joven en su casa de Tigre, el 10 de octubre de 2009. El hecho se imputó a dos jóvenes de 16 y 17 años, que fueron encerrados provisoriamente en un Instituto de Menores hasta alcanzar la edad suficiente para la prescripción de penas. El análisis se aborda desde una perspectiva comunicacional, que se sirve de supuestos teóricos provenientes de los campos del periodismo y del control social. El modo de abordaje emplea técnicas cualitativas a fin de indagar los mecanismos de la producción de noticias en los noticieros: América Noticias, Visión 7, Telefé Noticias, Todo Noticias y Canal 5 Noticias.","palabras_clave":"JUVENTUDES|DELITO|CASTIGO|DISCURSOS PERIODÍSTICOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81845,"idioma_id":5,"titulo":"Historia y memoria en el arte conmemorativo. Los relieves de José Fioravanti en el Palacio Municipal de Morón","resumen":"Si la construcción del Palacio Municipal de Morón fue una de las obras más importante de la gestión política conservadora en la provincia de Buenos Aires, los relieves que coronan el edificio nos han dejado un claro y a la vez penoso testimonio de los hechos que inauguraron aquella época de la República Argentina. Las obras son el corolario de una época conflictiva que ha contado con sectores detractores y sectores adherentes, y aun hoy generan conflictos conviviendo con una comunidad que se hace partícipe y miembro activo de su historia y su memoria","palabras_clave":"ARTE CONMEMORATIVO |MEMORIA |JOSE FIORAVANTI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81853,"idioma_id":5,"titulo":"Alasitas 2012: Un Ritual Andino En La Ciudad De Buenos Aires","resumen":"La fiesta de Alasitas es en la actualidad una celebración de carácter urbano si bien remite al ancestral calendario agrario andino. Esta ceremonia al dios Ekeko es una de las tantas prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.ancestral calendario agrario andino. Esta ceremonia al dios Ekeko es una de las tantas prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.prácticas culturales que los inmigrantes bolivianos pusieron en la escena de la ciudad deBuenos Aires y es realizada cada 24 de Enero desde 2003 en la wak´a de Parque Avellaneda, organizada por Centro Cultural Autóctono Wayna Marca. En la feria, donde se compran las miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no seponen en juego solo los anhelos sino también las particularidades y los conflictos de lacomunidad boliviana-argentina residente en la ciudad.miniaturas de aquellas cosas que de desean tener realmente durante el año entrante, no s","palabras_clave":"ALASITAS |WAK´A|RITUAL ANDINO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81891,"idioma_id":5,"titulo":"La malasangre de Griselda Gambaro: un estudio sobre su recepción","resumen":"En el presente trabajo nos proponemos un análisis de la recepción de sus obras a partir del estudio de la puesta  La malasangre de Griselda Gambaro, texto dramático escrito en 1981 y que fue llevado a escena el 17 de agosto de 1982 en el teatro Olimpia bajo la dirección de Laura Yusem y su reposición se realizó en 2005, en el teatro Regina, también con dirección de Yusem. Para esta labor, hemos no sólo estudiado las críticas académicas sino que hemos accedido y profundizado sobre el archivo del material periodístico de estos dos textos espectaculares que como vemos varían en cuanto a su momento histórico en el que se produjeron. Asimismo, y con el fin de dar cuenta de cómo estas dos producciones espectaculares circularon y fueron recepcionadas por el público y la crítica de ese entonces, tomamos especialmente los trabajos elaborados por Hans Robert Jauss (1976, 1986) ya que constituyen herramientas metodológicas adecuadas que permitió la reconstrucción del \u201Chorizonte de expectativa\u201D de la época.Partimos de la hipótesis de que si por un lado, la crítica periodística correspondiente al estreno de La malasangre en 1982 leyó esta obra desde la innovación de su poética autoral que por esos años se inscribe dentro del realismo crítico (abandonando relativamente la neovanguardia pero manteniendo gran parte de sus procedimientos absurdistas), revalorando la transparencia del mundo digético de la obra, al mismo tiempo que rescató un diálogo entre teatro y sociedad; por otro lado, la crítica periodística constitutiva de su reposición en el 2005, lee este mismo texto espectacular desde \u201Cel halo de nostalgia\u201D que produjo la aparición de esta pieza en 1982, como así también puede \u201Cleer\u201D y \u201Csignificar\u201D de manera más acentuada esa relación con el contexto histórico de la Argentina durante su dictadura militar, aspecto ya sugerido, por el universo periodístico de los 80\u2019. Asimismo, la crítica contemporánea a La malasangre del siglo XXI consolida el lugar de centralidad de esta dramaturga argentina, a la vez que canoniza este texto espectacular en el campo teatral argentino.","palabras_clave":"Teatro argentino|recepeción|puesta en escena|siglo XX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81899,"idioma_id":5,"titulo":"La línea de sombra: literatura latinoamericana y ciencia ficción en tres novelas contemporáneas","resumen":"El relato cyberpunk ha sido señalada más de una vez como el último gran movimiento dentro de la literatura de ciencia ficción. Y a pesar de que se han inventariado con mayor o menor fortuna su iconografía y sus recursos, menos parece haberse prestado atención al modelo enunciativo de la variante. Ese modelo, que articula la densidad informativa de la prosa con el desinterés del narrador, puede rastrearse hasta la década del sesenta y cincuenta, y hasta la obra de J.G. Ballard. Así, contra lo que parece opinar la crítica, el cyberpunk es el fin de las ilusiones modernas de la ciencia ficción, menos porque viene a cuestionar el modelo de la ?new wave?, que porque resulta su continuación lógica. El efecto fue la desactivación del corazón epistémico del relato de ciencia ficción, que tendrá como corolario la posibilidad de articular el género casi con cualquier matriz textual (y el éxito de Criptonomicón como novela de ciencia ficción puede presentarse como ejemplo).          Interesa aquí el modo en que esa intersección entre relato social y tecnología, territorio y subjetividad se articulan en tres novelas publicadas en el sur del continente en el fin de siglo: Las islas (1998) del argentino Carlos Gamerro; El delirio de Turing (2003) del boliviano Edmundo Paz Soldán, y El encierro según Nicolás (2004), del uruguayo Gabriel Peveroni. En los tres casos se trata de relatos en los que la escena tecnológica (el Chat, el juego de video, el hackeo) resulta absorbente y, en el límite, se propone como objeto autónomo. Notablemente, sin embargo, estos relatos configuran mecanismos por los cuales es necesario luchar con la apatía y retomar un espacio urbano que se presenta como territorio apocalíptico o irreal.Encontraremos en los motivos y en la enunciación de la escena tecnológica las formas del cyberpunk, la apatía del ?jinete de la consola?, su presencia en novelas que tal vez ya no sean relatos de ciencia ficción. Esa presencia, sin embargo, también sugiere que, al menos en Latinoamérica, su retoma es un modo de devolverle capacidad epistémica a eso que solíamos llamar ciencia ficción.","palabras_clave":"LITERATURA CONTEMPORÁNEA|CIENCIA FICCIÓN|AMÉRICA LATINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":81903,"idioma_id":5,"titulo":"De la luna al sol: para una historia de los viajes espaciales","resumen":"El artículo diseña una periodización de las formas en las que la ciencia ficción imaginó el viaje espacial, subrayando la importancia del cine para la constitución de su imaginario.","palabras_clave":"Ciencia ficción|Historia|Género"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82101,"idioma_id":4,"titulo":"Bordetella holmesii in children suspected of pertussis in Argentina","resumen":"We describe nine patients (eight aged <1 year) clinically diagnosed with pertussis yet laboratory-confirmed with Bordetella holmesii infections, a human pathogen normally isolated from blood. Most patients reported cough and cold symptoms. No death was reported. We report B. holmesii isolation in infants with respiratory symptoms in Argentina.","palabras_clave":"BORDETELLA|HOLMESII|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82213,"idioma_id":5,"titulo":"Para una lectura crítica del desarrollo humano","resumen":"El presente trabajo propone una lectura crítica del discurso del desarrollo humano articulado por Amartya Sen en Desarrollo y Libertad, desde el enfoque de la gubernamentalidad. En primer lugar, se precisa la perspectiva teórica adoptada, haciendo hincapié en las particularidades de la razón gubernamental neoliberal, marco en el que emerge el discurso del desarrollo humano. Se rastrea, luego, un conjunto de premisas del modelo de la elección racional, que brinda elementos conceptuales al discurso del desarrollo humano. A partir de estas claves, se examina una serie de postulados vertebradores de la propuesta de Amartya Sen, a los fines de identificar algunos de los efectos que ha producido el discurso del desarrollo humano en términos de concepción de la pobreza y de los dispositivos de intervención sobre ella.","palabras_clave":"GUBERNAMENTALIDAD|NEOLIBERALISMO|ELECCIÓN RACIONAL|DESARROLLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82252,"idioma_id":4,"titulo":"Molecular determinants for the line tension of coexisting liquid\/liquid phases in monolayers","resumen":"        The line tension (l)  in biphasic membranes has been determined in monolayers and bilayers using a  variety of techniques. In this work we present a novel approach to the determination  of l  in monolayers with liquid\/liquid phase coexistence, overcoming several of the  drawbacks of current techniques. Using our method, we determined the line  tension of liquid\/liquid phases in binary mixtures of different lipids and a  molecule similar to cholesterol but less oxidable. We analyzed the effect of  the hydrocarbon chain length and the polar head-group of the non-sterol lipid  and found the latter to exert much more influence than the former. The presence  of PE led to high l  values, PG to low values and PS and PC to intermediate values. The line tension  showed a strong correlation with the critical packing parameter of the  phospholipid. The spontaneous curvature displayed by the phases constituted by  a particular lipid appears to be an important parameter for determining the  line tension in mixed films.   ","palabras_clave":"DOMINIOS LIPIDICOS|TENSION DE LINEA|COLESTEROL|COEXISTENCIA LIQUIDO\/LIQUIDO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82272,"idioma_id":5,"titulo":"La autoridad profesoral en la Universidad contemporánea. Aportes para pensar las transformaciones del presente","resumen":"En la actualidad, el tema de la autoridad constituye una zona problemática, cuya indagación permite rastrear y pensar la articulación entre la condición juvenil -como territorio de experiencias en el que se pueden observar tensiones en los procesos de transmisión y herencia cultural- y la institución universitaria. En este artículo realizaremos un desarrollo teórico de dicho concepto, recuperando en primer término los debates que tienen lugar a partir de la modernidad, entendida como una particular condición de la historia en que los modos tradicionales de entender la autoridad van a ser cuestionados. Abordaremos luego las transformaciones en torno a la autoridad observadas en las instituciones educativas del presente. Consideraremos, por último, las visiones de estudiantes de la Universidad Nacional de Rosario sobre la autoridad de los profesores, teniendo en cuenta sus interpretaciones sobre los vínculos caracterizados por la asimetría en materia de conocimiento.","palabras_clave":"AUTORIDAD|EDUCACIÓN SUPERIOR|RECONOCIMIENTO|RELACIÓN ESTUDIANTES-PROFESORES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82328,"idioma_id":5,"titulo":"Estimación en laboratorio de la toxicidad de biopreservantes tánicos mediante la técnica de soil block","resumen":"Los tratamientos preservantes amplían las posibilidades de uso de las maderas a partir del aumento de su resistencia a la degradación fúngica (durabilidad) y, consecuentemente, de su vida útil en situaciones para las que no presentan adecuada durabilidad natural. En términos generales, la preservación involucra la utilización de compuestos químicos potencialmente perjudiciales para el ser humano y para el medio ambiente. A causa de ello, la sustitución de dichos compuestos por extractivos provenientes de especies con alta durabilidad constituye una alternativa a considerar.   \t  \tEl objetivo del trabajo fue estimar la toxicidad de biopreservantes elaborados en base a extractos tánicos de quebracho colorado (Schinopsis balansae Engl.) sobre hongos xilófagos, mediante ensayos en laboratorio, aplicando la técnica del soil-block.   \t  \tSe trabajó con madera de pino elliotti (Pinus elliottii Engelm.) constituida en su totalidad por albura, preservada por vació-presión (IRAM 9600) con soluciones hidrosolubles identificadas como Colatan IPG-A y Colatan IPG-B, elaboradas con extractos tánicos de quebracho colorado y reforzadas con sales minerales más un fijador de taninos.  \t  \tEn la madera impregnada fueron evaluadas la penetración y la retención de los preservantes, su distribución en el leño mediante microscopios estereoscópico y electrónico de barrido y la toxicidad de los mismos según norma IRAM 9518 en probetas expuestas a Pycnoporus sanguineus y Gloeophyllum sepiarium, hongos responsables de pudrición blanca y castaña, respectivamente.   \t  \tLa penetración de los preservantes en el leño fue total. Los valores de retención obtenidos fueron de 18,85 Kg\/m3 y 19,40 kg\/m3 para IPG-A e IPG-B, respectivamente. Las soluciones se distribuyeron uniformemente en el tejido leñoso y se depositaron en las vías naturales de colonización fúngica. La madera tratada incrementó significativamente su resistencia a la degradación fúngica poniendo en evidencia el efecto tóxico de los productos ensayados. La mayor toxicidad se registró sobre la cepa de pudrición castaña, particularmente con el producto IPG-A. El tipo de penetración, los valores de retención y la distribución de las soluciones en el leño contribuyeron a explicar estos resultados.   \t  \tEn la madera de Pinus elliottii y ante las condiciones descriptas, Colatan IPG-A e IPG-B resultan tóxicos para las cepas de ensayo y, en consecuencia, representan una alternativa natural de aumento de la resistencia a la degradación, en particular a la ocasionada por los hongos responsables de pudrición castaña.","palabras_clave":"EXTRACTOS TÁNICOS|SCHINOPSIS BALANSAE|PYCNOPORUS SANGUINEUS|GLOEOPHYLLUM SEPIARIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82534,"idioma_id":4,"titulo":"Phylogenetic analysis of the late Cambrian-early Ordovician genus Parabolinella Brøgger (Trilobita, Olenidae)","resumen":"Phylogenetic relationships among species of the family Olenidae (Trilobita, Ptychopariida) were traditionally established by the direct comparison of morphological features and the evaluation of stratigraphic placement. In this study, a cladistic analysis of Parabolinella Brøgger is conducted in order to test the supposed monophyly of the genus and to determine the relationships of its species. Twenty-one taxa (sixteen of this genus) from the late Cambrian and Tremadocian of Baltica, Avalonia, Laurentia, South China and the western margin of Gondwana were revised. Forty non-ordered characters were considered in the analysis, 34 belonging to the cephalon, four to the pygidium, and two to the thorax. Some of these characters were specially defined for this study. The phylogenetic analysis was performed under unweighted parsimony.  The obtained tree is partially consistent with the stratigraphic record of the studied species and shows correspondence with global late Cambrian and early Ordovician palaeogeography. Parabolinella may have originated in deep water sites of the Oaxaca region, Mexico and then migrated to other regions. The genus diversified in outer shelf facies of the Baltica Province during the late Cambrian and Tremadocian, whereas it would have dispersed to the South China Province in early Tremadocian times.","palabras_clave":"TRILOBITA|OLENIDAE|PARABOLINELLA|FURONGIAN|TREMADOCIAN|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82600,"idioma_id":5,"titulo":"Ley 26.331 Mecanismos de compensación. Dificultades y propuestas","resumen":"    The purpose of this paper is to present the  instrument of payment for environmental services (PSA), discuss its theoretical  basis and application to the management of native forests in the framework of  the law 26,631 Protection of Forests Natives. The PSA seeks to implement  market-based instruments to generate efficiency in the management of natural  resources. We conclude that land use and efficient use of the law?s found can  be achieved through subsidies to small producers, in a system of PSA  public-private like a part of a strategy of sustainable multiple use. This  would slow down deforestation process and would diversify exportation with for hardwood  products.","palabras_clave":"Ley 26.631|deforestación|presupuestos mínimos|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82663,"idioma_id":4,"titulo":"A new species of Cnemidophorus (Squamata, Teiidae) from the South American Chaco.","resumen":"Comprising one million of square kilometres, the Chaco biome is one of the largest open formations of South America, and part of a biogeographic diagonal in loose continuity with the Cerrado, to north, and the Patagonian Monte to south. Until recent years only one species of Cnemidophorus of the ocellifer group was recognized, C. ocellifer (Spix), but in the last decade several new species from the group has been described to Caatingas and Cerrado. In this paper a new species of Cnemidophorus in the ocellifer group, previously regarded as the southernmost population of C. ocellifer, is described. Analyses of external morphology revealed that a number of traits known to be taxonomically informative differ from trait combinations known to other species of the genus. The new species is bisexual, and distinguished from all other taxa of Cnemidophorus by its own combination of character states: it has 75-98 granular dorsal scales across midbody; 184-212 dorsal scales along vertebral line; 15-19 femoral pores in total; 25-31 lamellae under fourth toe; two rows of enlarged prebrachial plates; two rows of scales along the inferoposterior half of the calf of males bearing erected thorn-like borders; 23-26 scales around the tail on the fifth complete postcloacal ring; 5 superciliaries; frontonasal scale subrhombical, wider than long; striped pattern on body and tail with unfading of white stripes in adults, and vertebral stripe absent.The range of the new species in Paraguay and Argentina strongly suggests it is endemic to the Chaco biome. Its presence in the near Bolivian Chaco is expected.","palabras_clave":"CNEMIDOPHORUS|LIZARDS|OCELLIFER SPECIES GROUP|SQUAMATA|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82665,"idioma_id":5,"titulo":"?Territorialidades manufacturadas?: Lógicas político-institucionales y gestión del espacio. El caso PNDOT","resumen":"    Durante los últimos años hemos  asistido a una visibilización creciente de los conflictos en torno al  territorio urbano y rural que dan cuenta del desigual acceso y disfrute que  experimentan diferentes grupos poblacionales en nuestro país. Lejos de entender  el territorio en términos físicos, este se presenta como espacio y objeto de  lucha donde tienen lugar relaciones políticas, económicas, sociales, culturales  e históricas que, en su tensión y confrontación permanente, definen límites,  prácticas y patrones de organización social. En este trabajo nos detendremos en  analizar la lógica político-gubernamental ?a través de una política pública-  que pone en escena una racionalidad del Estado en relación a la gestión del  territorio y sus bienes. Nos centraremos en la Política y Estrategia Nacional  de Desarrollo y Ordenamiento Territorial (2004-2016) con el objetivo de trazar  un estudio crítico respecto de los supuestos ideológicos que la inspiran.  ","palabras_clave":"Conflicto |Territorio  |Políticas Públicas|Gubernamentalidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82666,"idioma_id":4,"titulo":"Abnormal colour pattern in a wild specimen of Cnemidophorus from the lacertoides species group (Squamata, Teiidae)","resumen":"Por tratarse de una 'Short communication' no posee resumen (se presenta en&nbsp;pdf como texto completo).","palabras_clave":"LIZARDS|CNEMIDOPHORUS|ABNORMALITY|URUGUAY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82671,"idioma_id":5,"titulo":"Fichas de los taxones: Emydidae, Kinosternidae, Testudinidae, Chelidae.","resumen":"Se presenta el detalle de las especies de tortugas amenazadas de la República Argentina. Cada ficha individual reporta la categoría 2012, la categoría anterior en el país, la categoría UICN, la justificación para su actual recategorización, y sugerencias y acciones de conservación para cada taxón.&nbsp;","palabras_clave":"TORTUGAS|CONSERVACION|ESPECIES AMENAZADAS|LISTA ROJA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82758,"idioma_id":4,"titulo":"Searching Simkania negevensis in environmental waters","resumen":"Simkania negevensis is an obligate intracellular bacterium grouped into the order Chlamydiales. This new amoeba-resistant bacterium represents a novel aetiologic agent of bronchiolitis and community-acquired pneumonia in both adults and children. It has been suggested that Simkania could be an ubiquitous microorganism presented in water environments. In the natural history of infections with amoeba-related bacteria encountered in aquatic habitats, the transmissions by environmental aerosols or contaminated water\/air systems have been extensively recognized. Therefore, understanding the feasibility of Simkania infection by these or similar routes is relevant.In the present work, we investigated the prevalence of this novel disease-associated microorganism in water samples from different sources by real-time PCR (qPCR). Our results show Simkania detection in 5 of 185 water analyzed samples (2.7%: 2 of 88 cooling towers and 3 of 8 waste water samples). However, no Simkania was detected in a drinking water.","palabras_clave":"Simkania negevensis|cooling towers|environmental water samples|real time PCR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82762,"idioma_id":4,"titulo":"Amoeba-related health risk in drinking water systems: could amoebae monitoring be a complementary approach to current quality control strategies?","resumen":"Culture-based methods for fecal indicator microorganisms are the standardprotocol to assess potential health risk from drinking water systems. However, these traditional fecal indicators are inappropriate surrogates for disinfection-resistant fecal pathogens and the indigenous pathogens that grow in drinking water systems. There is now a range of molecular-based methods, such as quantitative PCR, which allow detection of a variety of pathogens and alternative indicators. Hence, in addition to targeting total Escherichia coli (i.e., dead and alive) for the detection of fecal pollution, various amoebae may be suitable to indicate the potential presence of pathogenic amoeba-resisting microorganisms, such as Legionellae. Therefore, monitoring amoeba levels by quantitative PCR could be a useful tool for directly and indirectly evaluating health risk and could also be a complementary approach to current microbial quality control strategies for drinking water systems.","palabras_clave":"amoeba|bacterial pathogen|contaminant candidate list|drinking water systems|quantitative PCR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82793,"idioma_id":5,"titulo":"La vida social de las cosas y los artefactos-documentos del Museo de Carmen de Patagones","resumen":"Esta nota da apertura a la nueva sección de la revista Corpus, Archivos virtuales de la alteridad americana, denominada Espacio Archivos y Museos. Se presenta también la institución con la cual se inaugura la sección, el Museo Histórico Regional Emma Nozzi (MHREN) de Carmen de Patagones, provincia de Buenos Aires. Se describen las características de dicho museo y se justifica su elección para iniciar este canal de comunicación y difusión entre archivos, bibliotecas y museos. Por último, se introduce al lector en la riqueza de las colecciones del MHREN mediante el comentario sobre dos de sus artefactos-documentos, el toki o clava de mando del cacique Foyel y el acuerdo que éste firmó con el comandante Liborio Bernal en representación del gobierno argentino en 1873.","palabras_clave":"ARCHIVO|MUSEO|DOCUMENTO|HISTORIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82797,"idioma_id":6,"titulo":"Sur les traces du Géant Patagon.  L histoire de la collection Henry de La Vaulx du musée du quai Branly (1896-1897)","resumen":"Nota: la autoría de este artículo es en estricto orden alfabético, indicativo del protagonismo equilibrado entre ambos coautores.  L article synthétise les résultats d une recherche entreprise par les   auteurs en 2006. Elle avait pour objectif de restituer la cohérence   historique d une expérience anthropologique particulière: celle de la   mission d Henry de La Vaulx en Patagonie (1896-1897), menée quinze ans   après l expansion argentine vers les régions du sud, contrôlées   jusqu alors par les Mapuche et Tehuelche ou Patagons. Le corpus   matériel et documentaire qui résulta de cette mission fut, après son arrivée en France, dispersé entre plusieurs institutions parisiennes. Aussi a-t-on tenté d en reconstruire l intégralité par l analyse combinée des artéfacts affectés au musée du quai Branly en 2004, la lecture du récit de voyage, ainsi que l interprétation des photographies et du corpus documentaire produit par l explorateur français. Après une discussion sur les antécédents historiographiques qui explicite la   méthodologie adoptée, l article, à la croisée entre l ethnologie, l histoire et l histoire des collections, présente les dimensions coloniale, anthropologique et ethnographique du travail de collecte et soulève le problème de l historicité des récits et des objets produits et conservés dans un contexte de crise pour les populations de Patagonie.","palabras_clave":"Patagonie|Mapuche-Tehuelche|exploration scientifique|musée|collections"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82880,"idioma_id":4,"titulo":"Rheological properties of aqueous alumina-alumina-doped Y-PSZ suspensions","resumen":"The effect of the substitution of alumina (Al2O3) by 0.3 wt% Al2O3-doped 3 mol% yttria-partially stabilized zirconia (Y-PSZ) on therheological properties of concentrated aqueous slips was studied. Al2O3?Al2O3-doped Y-PSZ aqueous suspensions with different Al2O3-doped YPSZcontents: 0, 22 and 50 vol% were prepared using ammonium polyacrylate (NH4PA) as dispersant. The particle size distributions of Al2O3 andAl2O3-doped Y-PSZ powders were similar; however, the particle shape and the surface coating of alumina conferred a markedly higher specificsurface area to the Al2O3-doped Y-PSZ powder. The substitution of Al2O3 by Al2O3-doped Y-PSZ in the mixtures decreased the negative surfacecharge of the powders at pH 9, thereby increasing the amount of NH4PA adsorbed and consequently the electrosteric repulsion between particles.However, the viscosity and yield stress values increased with increasing Al2O3-doped Y-PSZ content for all the solid loading studied. This could be explained by a larger interaction size of the Al2O3-doped Y-PSZ particles which resulted in a higher effective volume solid fraction and a lower amount of free-liquid available for flow.","palabras_clave":"Al2O3Al2O3-DOPED Y-PSZ SUSPENSIONS|DISPERSION|RHEOLOGICAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":82899,"idioma_id":4,"titulo":"Pure Pairing Modes in Trapped Fermion Systems","resumen":"We present numerical predictions for the shape of the pairing fluctuations in harmonically trapped atomic 6Li   with two spin projections, based on the fluiddynamical description of   cold fermions with pairing interactions. In previous works it has been   shown that when the equilibrium of a symmetric mixture is perturbed, the   linearized fluiddynamic equations decouple into two sets, one   containing the sound mode of fermion superfluids and the other the   pairing mode. The latter corresponds to oscillations of the modulus of   the complex gap and is driven by the kinetic energy densities of the   particles and of the pairs. Assuming proportionality between the heat   flux and the energy gradient, the particle kinetic energy undergoes a   diffusive behavior and the diffusion parameter is the key parameter for   the relaxation time scale. We examine a possible range of values for   this parameter and find that the shape of the pairing oscillation is   rather insensitive to the precise value of the transport coefficient.   Moreover, the pairing fluctuation is largely confined to the center of   the trap, and the energy of the pairing mode is consistent with the   magnitude of the equilibrium gap.","palabras_clave":"Fermion superfluid|Harmonic confinement|Pairing fluctuations|Massive mode"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83020,"idioma_id":5,"titulo":"Partituras críticas. Sobre Caligrafía Tonal, de Ana Porrúa","resumen":"Si la poesía tiene fama de discurso arduo, espinoso, entonces la poesía contemporánea marcaría un plus de dificultad que podemos adjudicar a la proximidad histórica en la relación entre la mirada y su objeto, cercanía temporal que parece activar cierta desfocalización, cierta distorsión frecuente. Por otro lado, se suma una cuestión casi fenomenológica: me refiero a una especie de resistencia analítica, como si hubiera algo del orden de lo refractario en la textura crítica de las poéticas del presente. Los físicos suelen dar dos ejemplos clásicos de refracción: uno es el modelo del lápiz sumergido en un vaso con agua, que el observador percibe como quebrado; el otro, los espejismos en el desierto, en las rutas. La lectura, entonces, como espejismo del texto poético, como falsa duplicación, quiebre simulado, pura illusio, es decir, puro artificio, una retórica que termina por clausurar -aunque nunca anula completamente- la experiencia del texto: trabajo -del cuerpo- que deviene práctica de escritura. En este orden de la crítica argentina de poesía contemporánea, Caligrafía tonal, el libro de Ana Porrúa que acaba de publicar la editorial Entropía, constituye una apuesta novedosa y singular. Recién hablaba de una relación refractaria entre crítica y poética, donde la crítica, muchas veces, aparece como sustraída ya no de su capacidad de mirar (se puede ver incluso con los ojos cerrados), sino de su capacidad de mirar al Otro (al objeto) y cuando pretende leer, en realidad lo leído es su propia textualidad especular, duplicada, espejada: vacía. En Caligrafía tonal asistimos, por el contrario, a una relación que podríamos llamar, más bien, proyectiva: para poder escribir, el crítico debe construir, en simultáneo, su objeto de lectura y sus modos de leer, ambos entendidos como proyecciones: imágenes diseñadas y amplificadas a partir de los textos poéticos. Es decir: no hay espejismo, duplicación, sino pura creación, que a la vez se propone como reinvención de los materiales. En otras palabras: éste es un libro que habla de una serie ecléctica de textos poéticos, no un libro que habla de teorías y conceptos que sirven para explicar algo (ecléctico) de la poesía que finalmente (felizmente) queda sin explicar. ","palabras_clave":"Poesía argentina contemporánea|Crítica literaria argentina contemporánea"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83023,"idioma_id":5,"titulo":"Un pellizco sobre la tela del relato. Sobre cuatro títulos de la editorial El broche","resumen":"Reseña sobre tres títulos de la editorial El Broche.","palabras_clave":"Literatura argentina contemporánea|Editoriales independientes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83027,"idioma_id":5,"titulo":"Operaciones de traducción en la revista 18 whiskys","resumen":"La revista de poesía 18 whiskys  (1990-1991) es un   espacio de escritura construido a partir de un modo de  traducir por   medio del cual establece sus coordenadas en el campo poético  argentino   de la época. A lo largo del trabajo observaremos, por un lado, cómo  las   operatorias de traducción activan ciertas relaciones entre palabra e    imagen; y por otro, cómo las mismas ordenan uno de los tópicos más   importantes  de la revista: las figuraciones de Padres e Hijos que   aparecen diseminadas en  poemas, textos críticos y entrevistas.   Finalmente, analizaremos el modo en que  estas operatorias discursivas   desembocan en la instalación de una poética  emergente que se presenta a   sí misma como \u201Cnovedad\u201D, ya que por medio de las  traducciones se   construye, como veremos, una especie de grado cero de la  enunciación:   una instancia discursiva donde el pasado aparece como una huella  que ha   perdido su lugar de origen y el presente se impone como el único punto    de partida posible.","palabras_clave":"Poesía argentina contemporánea|Revistas literarias|Dispositivo de edición independiente"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83031,"idioma_id":5,"titulo":"Todo lo sólido se desvanece en el aire. Sobre La tendencia Materialista. Antología crítica de la poesía de los noventa, de Mazzoni, Selci y Kesselman","resumen":"La tendencia materialista. Antología crítica de la poesía de los noventa (Paradiso, 2012), compilada por Violeta Kesselman, Ana Mazzoni y Damián Selci, reúne selecciones de la obra de siete poetas argentinos: Fabián Casas, Washington Cucurto, Martín Gambarotta, Alejandro Rubio, Sergio Raimondi, Fernanda Laguna y Juan Desiderio. Otras antologías ya habían hecho foco en los noventa: entre ellas, Poesía en la fisura (Del Dock, 1995), de Daniel Freidemberg, y Monstruos. Antología de la joven poesía argentina (FCE, 2001), de Arturo Carrera, están entre las más importantes. En los últimos años, las ediciones de distintas antologías de poesía argentina se multiplicaron enfáticamente: tenemos, entonces, la Antología de la nueva poesía argentina (Perceval Press, 2009), de Gustavo López; Otro río que pasa. Un siglo de poesía argentina contemporánea (Bajo la luna, 2010), de Jorge Fondebrider; 200 años de poesía argentina (Alfaguara, 2010), de Jorge Monteleone; y Si Hamlet duda le daremos muerte. Antología de poesía salvaje (Libros de la talita dorada, 2010), de Julián Axat. La tendencia materialista se inscribe, necesariamente, en este contexto, a la vez que se diferencia de él: mientras en las antologías mencionadas predomina, de manera invariable, un gesto panorámico de muestreo, la antología de Kesselman, Mazzoni y Selci se instala en el polo opuesto al hacer hincapié, en cambio, en la radicalidad del recorte: 'el sentido panorámico-informativo que motivó los trabajos de Freidemberg y Carrera pierde pertinencia. Pasado el tiempo, parece ser más útil aventurar la función selectiva de la antología.' Pero no hay que entender selección por exclusión: porque, en este caso, el recorte no pretende, desde el vamos, ser representativo: 'El objetivo, en síntesis, fue menos armar una antología que un recorrido antológico por diversos complejos problemáticos. En cierto modo, este libro selecciona problemas, más que poetas.' No sería productivo, entonces, abordar la antología por lo que deja afuera, porque eso implicaría reclamar una pretensión que no tiene. Habría que leerla, luego, en su propia singularidad. ","palabras_clave":"Poesía argentina de los noventa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83180,"idioma_id":5,"titulo":"Cambios y continuidades en la Política de Vivienda Argentina (2003-2007)","resumen":"El gobierno argentino que asumió en el año 2003 abandonó los lineamientos del modelo neoliberal de los años noventa y adoptó una línea diferente de intervención del Estado en la economía y la sociedad. En ese marco propuso como uno de sus ejes de acciones importantes, realizar una fuerte inversión en obras públicas como estrategia de reactivación económica y generación de empleos. Con esta finalidad reestructuró la organización del Poder Ejecutivo, creando el Ministerio de Planificación Federal, Inversión Pública y Servicios, como organismo centralizado responsable de estas acciones. En este marco incorporó como uno de los temas centrales de gobierno, modificaciones a la política de vivienda, orientándola simultáneamente al mejoramiento del hábitat y a la reactivación productiva. Este trabajo caracteriza los cambios y las continuidades generales que introdujo esta política de vivienda, respecto a la implementada en los años noventa del siglo pasado, a partir de una metodología de análisis comparativa.","palabras_clave":"POLÍTICA DE VIVIENDA|MODELOS DE DESARROLLO|POLÍTICA FEDERAL DE VIVIENDA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83276,"idioma_id":2,"titulo":"BEWERTUNG MIKROSTRUKTURELLER BARRIEREN WÄHREND DER ERMÜDUNGSSCHÄDIGUNG VON DUPLEX-STÄHLEN BEI SEHR HOHEN ZYKLENZAHLEN","resumen":"By means of cyclic deformation experiments, using rotating bending, resonance and servohydraulic testing machines as well as ultrasonic fatigue devices, in combination with SEM surface analysis, it was shown that the fatigue damage behaviour of duplex  steels is governed by the presence of grain and phase boundaries. Depending on the spatial arrangement of the respective slip systems, the local formation of shear bands as well as their propagation across the boundaries can be explained. Later in the fatigue life, the shear bands act as nuclei for crack initiation, propagation and, eventually, fracture.","palabras_clave":"FATIGUE DAMAGE|DUPLEX STAINLESS STEELS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83359,"idioma_id":5,"titulo":"Aportes para una genealogía del ambiente desde una lectura biopolítica","resumen":"EL CONTEXTO RESULTA UN ELEMENTO A CONCEBIR EN LA BIOPOLITICA. LA POBLACION NO PUEDE CONSIDERARSE EN SENTIDO EXTRA SOCIAL, CULTURAL, HISTORICO.","palabras_clave":"OIKOS-ESTETICA|BIOPOLITICA|FOUCAULT|AGAMBEN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83437,"idioma_id":5,"titulo":"Consulta, participación y desarrollo","resumen":"Consulta, participación y desarrollo                                                                                                                                 María Pía Pacheco y Omar Jerez                                                                 (UNJu-CONICET, MTEySS)                                                                 Resumen                                                                                                                                 Analizar la realidad de los pueblos originarios, es un tema de gran controversia en los estudios socioculturales. Diferentes estudios han abordado las cuestiones étnicas poniendo el énfasis en los procesos arqueológicos, históricos, económicos, sociales, educativos, entre otros ejes. En la provincia de Jujuy, son escasos, o al menos fragmentariamente difundidos los trabajos que analizan la participación de los pueblos originarios en procesos de participación social y desarrollo.                                                                 En la presente ponencia intentaremos avanzar en algunas líneas de análisis a partir de responder los siguientes interrogantes:                                                                 ¿Son convocados los referentes de los pueblos originarios a participar en el diseño o formulación de políticas públicas? ¿Qué sector institucional convoca? ¿qué comunidades indígenas son convocadas en la participación? ¿Cómo son los mecanismos de convocatoria? ¿qué comunidades participan o tienen mayor visibilidad en la convocatoria y en la participación? ¿los planes y\/o proyectos generados desde el Estado, tienen en cuenta la diversidad cultural ?como expresión de la cultura nativa- al momento de planificar o diseñar sus estrategias de intervención? ¿cuál es la información que manejan las oficinas públicas sobre el tema? ¿Cuántas comunidades indígenas hay en Jujuy? ¿Cuántos son los indígenas en Jujuy? ¿Cómo se organizan?                                                                 La presente ponencia se nutre de dos vertientes de producción de datos primarios, a saber. Por un lado, forma parte de las actividades que venimos realizando en el marco del Proyecto de Investigación ?La situación de los pueblos originarios en las tierras bajas de Jujuy?, (SeCTER-UNJu). &nbsp;Por otro lado, parte de la ponencia es el resultado de la ?Evaluación Social de los Pueblos Indígenas de Jujuy? (MTEySS) que realizamos en el marco de un trabajo realizado para la Secretaria de Empleo del Ministerio de Trabajo de la Nación, durante el primer semestre del año 2009. Este trabajo ha combinado diferentes abordajes metodológicos, y aplicación de técnicas de recolección de datos, de base cualitativa y cuantitativa.                                                           ","palabras_clave":"DESARROLLO|CULTURA LOCAL|POLITICAS PÚBLICAS|PUEBLOS ORIGINARIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83525,"idioma_id":5,"titulo":"-\t?Al sur del río Cuarto: Chaján (1861-1876)?.","resumen":"Chaján fue un paraje habitado por euroamericanos durante la existencia de la Frontera Sur de Córdoba. Su ubicación geográfica, en los confines de la Sierra de Comechingones, hizo que entre 1861 y 1876 se constituyese en un lugar estratégico del espacio fronterizo. Desde 1861 y hasta el avance de la línea fortinera al río Quinto en 1869, Chaján estuvo localizado a la vera de rastrilladas vinculadas a los pasos sobre este río, frecuentemente utilizadas por indios y montoneras. Posteriormente se emplazó allí una posta militar destinada a servir de nexo entre el Detall de la Villa de la Concepción del Río Cuarto y la Comandancia de la Frontera Sur con sede en Villa Mercedes. Este rol estratégico de la posta de Chaján se acrecentó con la instalación del telégrafo en Río Cuarto, contribuyendo a la transmisión de las comunicaciones entre ambos centros neurálgicos de la Frontera.","palabras_clave":"POBLAMIENTO|AVANZADO|FRONTERA|SUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83533,"idioma_id":5,"titulo":"La concepción de espacio en el arte moderno brasileño. Aportes desde una lectura epistemológica","resumen":"A partir del análisis de obras de Lygia Pape, intentaremos demostrar la ausencia de una ruptura total en la concepción espacial del movimiento neoconcreto brasileño respecto de su predecesor, el movimiento concreto.   A su vez, recurriremos a las bases teóricas adoptadas por cada uno de los grupos artísticos en sus manifiestos fundacionales, de forma tal de poder comprender el universo epistemológico en el que concebían sus obras.   La hipótesis versará sobre la idea de que existió una exacerbación de la lectura fenomenológica por parte del Grupo Frente que confundió a la crítica en su postura de que el movimiento neoconcreto se oponía a la concepción espacial racionalista (propia del concretismo).  El seguimiento de la obra de Pape, a través de dos representativos trabajos pertenecientes a los distintos momentos mencionados del arte brasileño, servirá como excusa para ilustrar la convivencia de ideas supuestamente antagónicas.","palabras_clave":"ARTE MODERNO|ESPACIO|EPISTEMOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83537,"idioma_id":5,"titulo":"Tensiones entre miradas estéticas anti-idealistas y prácticas contemporáneas de arte-ciencia","resumen":"John Dewey y Ludwig Wittgenstein son dos autores claves de la discusión histórica por una nueva estética, opuesta a la tradición idealista. Su enfoque transgresor apuesta por la reunificación de la experiencia estética con el mundo, en el primer caso, y la comprensión del rol de la estética en función del juego de lenguaje en el que se inscriba culturalmente, de acuerdo al segundo caso. Aún siendo diferentes las contribuciones que ambos autores realizan sobre la definición de estética, persiste en ellos una necesidad de establecerla en función de una caracterización enfrentada a la idea de ciencia. La herencia moderna está presente en sus modos de pensar, articulados en base a distinciones binarias, que dificultan la tarea de comprensión del arte contemporáneo, sobre todo en lo que respecta a los desarrollo del sci-art, donde la transdisciplina de las obras borra los límites tradicionales de la separación arte-ciencia. Ejemplos claves serán citados en este trabajo con vistas a contribuir a la revisión de los debates que han hecho avanzar la discusión sobre el rol de la estética en el siglo XX pero que, sin embargo, resultan insuficientes como marco teórico para comprender las posibilidades cognitivas del arte.","palabras_clave":"EXPERIENCIA |LENGUAJE|CONOCIMIENTO|TRANSDISCIPLINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83541,"idioma_id":5,"titulo":"Mercado y resistencia: análisis de un género artístico contemporáneo inaprensible y su repercusión local en Argentina","resumen":"El objetivo del trabajo será retomar la hipótesis benjaminiana de destrucción del aura en el arte tradicional, a partir de la   aparición de los medios técnicos de reproducción, y enfrentarla con las manifestaciones conceptuales del siglo XX,   específicamente con las instalaciones artísticas.   La particularidad de este tipo de obras reside en su naturaleza efímera e interactiva que plantea una nueva relación   respecto del espectador. Son obras que no tienen una materialidad original y que tampoco son pensadas para la reproducción masiva. En este sentido se las podría considerar una excepción al mercado del arte por no tener original y, al   mismo tiempo, a la teoría estética, por no poseer aura.   Ante este escenario, considero necesario, por un lado, discutir la posibilidad de pensar a la instalación como una respuesta artística superadora frente al avance de la técnica y del mercado en el arte tradicional; y, por otro lado, problematizar el rol del coleccionismo en la supervivencia de este tipo de manifestaciones efímeras en Argentina, y sus similitudes y diferencias en relación con sus inicios modernos encarnados en la figura de Eduard Fuchs.","palabras_clave":"arte|mercado|aura"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83564,"idioma_id":5,"titulo":"EL CICLO BIOGEOQUÍMICO DEL OXÍGENO Y SUS POSIBLES ALTERACIONES: UN NUCLEO GENERADOR DE PROBLEMÁTICAS INTEGRADORAS PARA UN ABORDAJE INTERDISCIPLINAR ENTRE QUÍMICA, FÍSICA, BIOLOGÍA Y ECOLOGÍA","resumen":"Según Morín (2001) la interdisciplinariedad persigue como objetivo epistemológico la reunificación del saber y el logro de un cuadro conceptual global, mientras que como objetivo metodológico pretende investigar multilateralmente la realidad, por el propio carácter variado, multifacético y complejo de la misma y la necesidad de obtener un saber rápidamente aplicable, en consonancia con la creciente interrelación entre ciencia, tecnología y sociedad (Álvarez Pérez, 2004). Para esto se deben plantear ?nodos interdisciplinarios? que se deban estudiar desde el punto de vista de diferentes disciplinas, de acuerdo con las diversas capacidades de los alumnos, ya sea en un espacio extracurricular ó dentro de la currícula de la carrera.","palabras_clave":"DIDÁCTICA INTERDISCIPLINAR|ENSEÑANZA DE LAS CIENCIAS NATURALES|REALIDAD COMPLEJA|INVESTIGACIÓN ASISTIDA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83765,"idioma_id":5,"titulo":"SUSTANCIAS BIOACTIVAS EN ALIMENTOS REGIONALES: CUANTIFICACION Y USO EN FORMULACIONES ALIMENTICIAS","resumen":"El proyecto es una continuación eintegración de estudios que el equipo de investigación viene realizando desdeel año 2000 sobre diferentes formulaciones de alimentos, y cuyos resultados hansido presentados en distintos eventos científicos y publicaciones internacionales.Las líneas de investigación propuestas se centran en evaluar la composición demacro y micronutrientes, y determinar el contenido de sustancias bioactivas ofarmacobotánicas de alimentos producidos en la región. Con ello se lograráasociarle a estos alimentos y a las nuevas formulaciones alimenticiaselaboradas con ellos, un ?valor funcional?, debido a principios bioactivostales como: antioxidantes, polifenoles, pigmentos carotenoides, clorofílicos yantociánicos que deben estar en concentraciones recomendadas para ejercer elefecto benéfico sobre la salud, estado físico y mental. Otra sustancia como lainulina ha demostrado efecto benéfico y está presente en alimentos tales comoachicoria, tupinambur y alchofas.Para el logro de los objetivos, secomplementará la evaluación de sustancias bioactivas,&nbsp; con determinación de elementos contaminantesque hacen a la inocuidad alimentaria y el análisis de macro y micronutrientesque aporten valor nutricional.Además de la Facultad de CienciasAgrarias UNCuyo participan en el estudio el&nbsp;Centro de Frutas y Hortalizas Mendoza (Instituto Nacional de TecnologíaIndustrial) y la Facultad de Ciencias de la Nutrición y de Farmacia yBioquímica (Universidad Juan Agustín Maza) y la de Facultad de Farmacia y Bioquímicade la Universidad de Buenos Aires (UBA).El objetivo general es cuantificarsustancias bioactivas en alimentos regionales y utilizarlas en nuevasformulaciones alimenticias con principios funcionales y en forma específica seestá trabajando sobre la evaluación de: aceites vegetales, aceitunas, tomate,frutas y hortalizas frescas, frutos secos, frutos desecados y tupinambur (Helianthus tuberosus), determinando elcontenido de polifenoles, tocoferoles, flavonoides, antocianos, clorofilas ycarotenoides, macronutrientes y micronutrientes y los elementos contaminantespotencialmente presentes tales como aluminio, plomo y cadmio.La elaboración de las diferentesformulaciones alimenticias se está llevando a cabo en la planta experimental dela Facultad de Ciencias Agrarias de la UNCuyo.La metodología de análisis incluye eluso de instrumental específico como cromatografía de fase gaseosa y líquida,espectrofotometría: UV-visible, de absorción atómica y de emisión por plasmaacoplado inductivamente como así también la realización de análisis físicos,químicos, microbiológicos y sensoriales. Los datos se validaránestadísticamente con software específico.El proyecto contempla el compromisode la formación de Recursos Humanos con dos Tesis Doctorales, dos Tesis deMaestría y seis Tesis de Especialización en Formulación y Gestión de la Calidadde Alimentos Dietéticos y cuatro tesinas de Licenciatura en Bromatología.La transferencia de resultados estásiendo comunicada en eventos científicos pertinentes, cursos de capacitación ypor medio de redacción de manuales de extensión&nbsp;a las diferentes industrias relacionadas con la temática a estudiar.","palabras_clave":"SUSTANCIAS BIOACTIVAS|ALIMENTOS REGIONALES|CUANTIFICACION|FORMULACIONES ALIMENTICIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83772,"idioma_id":5,"titulo":"Caracterización de la probabilidad de disociación multifotónica IR de CDCl3 en presencia de Ar","resumen":"Se presenta el estudio del efecto de las colisiones con Ar y de la fluencia de irradiación en la disociación multifotónica infrarroja de CDCl3 con un láser de CO2 TEA mediante la técnica de Fluorescencia Inducida por Láser (FIL). La disociación de CDCl3 ocurre vía el canal CDCl3 + nhn 6 CCl2 + DCl. La configuración del sistema de detección posibilitó la determinación directa de la probabilidad de disociación por pulso en función de la fluencia para las distintas presiones de Ar. Por otra parte, por espectrometría FTIR se determinó la fracción  global de moléculas disociadas por pulso. La deconvolución de los valores obtenidos, suponiendo una distribución del tipo log-normal acumulada para la probabilidad de disociación por pulso, permitió la validación  de los resultados obtenidos por medio de la técnica FIL. Como resultado de la aplicación de ambas técnicas puede concluirse que las colisiones con Ar son poco eficientes para desexcitar los estados vibracionales del  CDCl3.","palabras_clave":"DISOCIACIÓN MULTIFOTÓNICA IR|FLUORESCENCIA INDUCIDA POR LÁSER|CDCl3"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":83920,"idioma_id":5,"titulo":"El tiempo como la mirada absuelta. Excurso a partir de la exposición fotográfica ?Esa belleza sin nombre? del grupo Una Muñeca Rusa","resumen":"La presente composición trata de ensayar una escritura acerca la absolución del tiempo en la fotografía, a partir de la muestra ?Esa Belleza sin Nombre? presentada por las cuatro artistas[1] residentes en la ciudad de La Plata (Argentina) que componen el colectivo Una Muñeca Rusa. El nombre del grupo remite a las Muñecas Rusas o muñecas anidadas, matryoshka, matrioshka, babushka o ?muñecas rusas? simplemente (Matryoshka Doll, 2000). Importa comprender que No miramos solo una cosa, siempre miramos la reciprocidad entre las cosas y nosotros mismos. Nuestra visión está en continua actividad, en continuo movimiento. Nosotros aprendiendo continuamente las cosas que se encuentran en una circularidad cuyo centro es ella misma, nuestra visión y el tiempo que no se parcela en la fotografía, sino que corre. Se desliza y nos deslizamos en la actualidad de la imagen que nos viene a decir cuáles son esas vinculaciones.  Cuerpos  estilizados y considerablemente fibrosos escapan de la materialidad, se purifican, devienen esculturas, a la vez que desmesuradamente estrechos y hasta sublimes o inspiradores de placer permiten reconocerlo en el dolor ajeno como experiencia de la naturaleza. La fotografía nos permite entrar en ella y comprender que estamos temporalmente dentro de algo que a su vez está dentro de algo más, como una muñeca rusa.","palabras_clave":"MUÑECAS RUSAS|ARTE|FILOSOFIA|FOTOGRAFIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84054,"idioma_id":4,"titulo":"Determination of sildenafil by preconcentration on  surfactant coated polymeric resin followed by  spectrofluorimetry","resumen":"The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XADTM resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micelar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng\/mL with linear range of 0.0003-7.0 &#956;g\/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.","palabras_clave":"SILDENAFIL|HERBAL MEDICINE|SPECTROFLUORIMETRIC ANALYSIS|SURFACTANT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84135,"idioma_id":5,"titulo":"Relación entre el estilo de vida y el estado nutricional en pacientes con Diabetes Mellitus Tipo 2 de la ciudad de Santa Fe, Argentina","resumen":"Introducción: La Diabetes Mellitus tipo 2 (DM2) es una de las patologías crónicas con mayor prevalencia en la sociedad actual. El estilo de vida cada vez más inadecuado de la población condiciona el estado nutricional favoreciendoel desarrollo de sobrepeso y obesidad. A su vez, el exceso de peso cumple un papel importante en la fisiopatología de la DM2.Objetivo: Establecer la relación entre el estilo de vida y el estado nutricional en pacientes con DM2.Materiales y métodos: Se estudiaron 50 pacientes adultos con DM2. Se determinó el estado nutricional según Índice de Masa Corporal (IMC, Organización Mundial de la Salud). El estilo de vida se evaluó mediante un cuestionario específico autoadministrado validado.Resultados: Se observó una elevada prevalencia de exceso de peso (30% sobrepeso, 56% obesidad) y un estilo de vida inadecuado (74%) caracterizado por hábitos alimentarios poco saludables, inactividad física, insuficiente conocimiento sobre la diabetes y emociones negativas respeto a la enfermedad. La probabilidad de presentar exceso de peso fue cinco veces superior en personas con un estilo de vida inadecuado.Conclusión: Los resultados sugieren que el estilo de vida inadecuado característico de la sociedad moderna, influye en el desarrollo de exceso de peso corporal y, por ende, puede incidir en el control de la DM2, complicandoaún más el pronóstico y el tratamiento de la enfermedad.","palabras_clave":"DIABETES MELLITUS TIPO 2|ESTILO DE VIDA|ESTADO NUTRICIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84395,"idioma_id":5,"titulo":"Mujer, Política y Generaciones:  Emar Acosta y Rosalía Garro","resumen":"La historia que permitirá conocer el mundo actual es la historia de procesos,  que dará cuenta de los cambios y movimientos que caracterizan la vida de los hombres, pero a través de los procesos y los distintos problemas que en ellos se plantean.Vincular el rol de la mujer en la política y en la generación en qué le tocó vivir no escapa al planteo realizado en párrafos anteriores. Teniendo en cuenta estas características, en este trabajo se analizarán los procesos históricos sanjuaninos del Siglo XX en su vinculación con la participación activa de la mujer en la política y su relación con la generación a la que perteneció, entendiendo que, una generación es una zona de quince años durante la cual una cierta forma de vida estuvo vigente. Para ello se estudian dos mujeres sanjuaninas Emar Acosta y Rosalía Garro recurriendo al aporte de la Historia Oral y al  análisis a la Teoría de las Generaciones planteada por José Ortega y Gasset (1883 ? 1955)","palabras_clave":"MUJER|POLÍTICA| GENERACIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84418,"idioma_id":5,"titulo":"Extracto de semillas de vid (Vitis vinífera L.) con actividad antioxidante: concentración, deshidratación   y comparación con antioxidantes de uso comercial.","resumen":"Los objetivos de este trabajo fueron: 1) Evaluar un proceso de concentración y deshidratación de un extracto polifenólico de semillas de vid (Vitis vinifera L.). El proceso debía conservar el poder reductor del extracto. 2) Valorar la eficiencia del antioxidante obtenido por comparación con antioxidantes de uso habitual en un producto vegetal susceptible de ser oxidado, tal como el jugo de manzanas. El extracto de semillas de vid fue concentrado a 60°C en un concentrador rotativo al vacío de laboratorio. La concentración de los compuestos fenólicos fue determinada por el método de Folin-Ciocalteu modificado. La actividad antioxidante se determinó midiendo el poder reductor, por el método de Oyaizu. La oxidación del jugo de manzanas se determinó por el método de Özoglu. El extracto concentrado obtenido fue deshidratado por dos métodos: liofilización y secado en lecho de espuma. A igual concentración fenólica, el extracto concentrado mostró mayor capacidad antioxidante que el extracto simple. El extracto secado en lecho de espuma conservó la misma capacidad antioxidante que el extracto concentrado. El extracto liofilizado experimentó una pérdida significativa de la actividad antioxidante. El extracto concentrado de semillas de vid inhibió la oxidación del jugo de manzanas en un 31,51%, el ácido ascórbico en un 2,60% y el dióxido de azufre en un 97,40%.","palabras_clave":"POLIFENOLES      | EXTRACTOS DE SEMILLAS |CONCENTRACIÓN|SECADO|JUGO DE FRUTAS|LIOFILIZACIÓN|ANTIOXIDANTES|DESHIDRATACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84430,"idioma_id":5,"titulo":"Mateo (1923) de Armando Discépolo y el yugo apremiante del progreso","resumen":"El 14 de marzo de 1923 encontramos el estreno del primer grotesco ?Mateo? en el Teatro Nacional, regenteado por Pascual E. Carcavallo. Hubo tres factores principales que influyeron para que el público no pudiera indagar el conflicto que planteó Discépolo en el nuevo microsistema: por un lado, los elementos residuales del sainete tragicómico presentes en esta obra dramática actualizados mediante los procedimientos de una poética popular de actuación que quitaron densidad dramática al planteamiento generacional del texto; por otro, la dificultad para deslindar el lugar donde se llevó a cabo la protopuesta en escena ?la denominada ?catedral del género chico?? de la nueva propuesta estética del grotesco que difería del género saineteril que usualmente se llevaba a escena; y, por último, la dimensión del conflicto plantead no cobró en el primer grotesco la gravedad que adquirió en los posteriores, donde se exacerbó la incomprensión, la discrepancia y el enfrentamiento entre padres e hijos. A pesar de estas características que cooperaron en la confusión en la recepción del nuevo género, la intervención de Discépolo en la nominación de su obra ??Mateo, grotesco en tres cuadros?? no pudo imprimir una mirada reflexiva a la crítica sobre la nueva textualidad.","palabras_clave":"Grotesco|Teatro|Modernidad|Subjetivismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84488,"idioma_id":5,"titulo":"Las condiciones de la fuerza de trabajo  en el Gran Buenos Aires. 1991-2006","resumen":"Las transformaciones del capitalismo a escala mundial, caracterizado por la reorganización de sus formas de dominación de la sociedad, que tiene específicamente en el ámbito de la producción una creciente imbricación entre trabajo productivo e improductivo, la disminución del peso relativo del proletariado industrial y el incremento de una masa de trabajadores asalariados relacionados al sector de servicios, hace necesario comprender las determinaciones de clase en un sentido amplio, de tal forma que contemple al conjunto de aquellos que para subsistir se ven obligados a vender su fuerza de trabajo. El marcado proceso de salarización que se constata en la Argentina nos lleva a considerar que la noción de clase, lejos de perder relevancia para el análisis de la sociedad actual, cobra, renovada, una centralidad ineludible. Hay que señalar que la categoría de trabajo no solamente sigue siendo relevante en tanto eje articulador de la sociedad, sino que el trabajo asalariado, el trabajo plenamente capitalista, la venta de fuerza de trabajo es la figura predominante y cada vez crece más en todos los ámbitos de la producción social.Ahora bien, constatar que el trabajo no ha perdido centralidad y mucho menos ha desaparecido, no significa afirmar que no se hayan producido grandes cambios en el mundo del trabajo. En principio, es posible señalar un doble movimiento en términos de composición de la clase obrera y en relación al mercado de trabajo.En el plano más estructural, de composición de la clase obrera, hay una tendencia a la homogeneización, un cierto acercamiento de la posición de los asalariados por el empobrecimiento de todas las capas de los trabajadores, por la precarización de todas las capas de trabajadores y la continua rotación entre ramas de actividad.Pero en el plano del mercado de trabajo existe una importante fragmentación. Porque en cualquier lugar de trabajo uno puede encontrar efectivos, contratados, pasantes, monotributistas, hay empresas tercerizadas. Es decir que por más que las situaciones sean semejantes en lo más básico, en lo inmediato se encuentra una diversidad de situaciones bastante marcadas (cuánto es el salario, a qué convenio responden, cuál es la patronal formal) y que atentan contra las posibilidades de unificación de la lucha y de unificación política de la clase. Lo cierto es que, cada vez con mayor notoriedad, las personas se ven obligadas para su subsistencia a vender lo único de que disponen: su fuerza de trabajo. Pero eso sí, en condiciones de extraordinaria inestabilidad e infame precarización. La prédica del fin del trabajo y la defunción de la sociedad salarial se contraponen al sostenido incremento de la productividad laboral y los crecientes índices de salarización.Esta investigación busca aportar algunos elementos acerca de los cambios producidos en la clase trabajadora en el período de consolidación de una nueva etapa de acumulación del capital en nuestro país. Si en 1975-76, con la dictadura militar genocida comienza a prefigurarse un nuevo modelo societal, es a partir de fines de la década del 80 ?que culmina con la crisis hiperinflacionaria que adquiría forma de un verdadero ?golpe de mercado?? cuando se crean las condiciones para la consolidación de un nuevo orden neoliberal. Nos interesa particularmente el período que abarca los últimos quince años y que se inicia con la privatización de las empresas estatales y la ?reestructuración? del Estado.","palabras_clave":"MERCADO DE TRABAJO|CLASE TRABAJADORA|ESTRUCTURA SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84516,"idioma_id":5,"titulo":"LAS TEORÍAS ETIOLÓGICAS DE LA ENFERMEDAD EN SOCIEDADES OTRAS Y LOS TAXA VERNÁCULOS OCCIDENTALES","resumen":"Este artículo discute las posibilidades  de que algunas creencias sobre el mal de ojo  en Ibero-América sean de raigambre indígena.  Enfatizamos que las creencias tomadas por  indígenas o por sincretismo de tradiciones  españolas e indígenas, en rigor revelan la síntesis  cultural entre antiguas concepciones académicas  popularizadas en América y el folklore aportado  por los inmigrantes del Viejo Mundo. En  virtud del objetivo propuesto, en primer lugar,  enfocamos las creencias sobre el mal de ojo en la  España del tiempo de la conquista, distinguiendo  los saberes de elite y los conocimientos médicos  sobre el mal de ojo, de aquellas otras tradiciones  y prácticas propias de los sectores populares,  las que para las elites eran supersticiones.  En el análisis del mal de ojo como un morbo  reconocido por la medicina oficial se destacan  diversos contenidos religiosos incorporados en  las concepciones sobre la salud. En segundo  término, exponemos las creencias sobre el mal  de ojo en Argentina, mostrando que aparecen  aquellas nociones que supuestamente revelarían  la influencia indígena, siendo imposible pensar  en la influencia de América Central o Méxicoen la Argentina. Luego se analizan creencias  sobre el mal de ojo de Bolivia, Paraguay, Perú,  Guatemala y México, enfatizando la síntesis  cultural mencionada. La discusión sobre los  posibles orígenes indígenas de las creencias en  el mal de ojo son enmarcados en una perspectiva  más amplia, que trae la comprobación que hiciera  Foster sobre el origen español de la clasificación  de las enfermedades, los remedios y los alimentos  en cálidos y fríos. Posteriormente, nos centramos  en la descripción del mal ojo en Ecuador realizada  por Estrella, para avalar los supuestos contenidos  quechuas. Y, finalmente, en los datos ofrecidos  por López Austin para probar el origen nahua de  la creencia en México. Nuestro análisis concluye  demostrando que cada uno de los aspectos que  fueron considerados de raigambre indígena son  ocurrencias del mal de ojo que se reiteran desde  Argentina a México, que están también presentes  en España y otros países del Viejo Mundo y que  en la mayoría de los casos eran saberes de elite","palabras_clave":"teorias etiológicas|taxas vernáculos|enfermedad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84547,"idioma_id":5,"titulo":"LAS TRAYECTORIAS ACADÉMICAS: DIMENSIONES PERSONALES  DE  UNA TRAYECTORIA ESTUDIANTIL. TESTIMONIO DE UN ACTOR?.","resumen":"Los estudios cuantitativos de la matrícula universitaria dan cuenta del rendimiento, ingreso y \/o egreso, deserción, éxito o fracaso de los estudiantes. La información que se obtiene de estas lógicas cuantitativas es global y no expresa las condiciones reales de evolución de la matrícula ni de la compleja situación de los estudiantes. Por cierto, la importancia de los valores que arrojan estos estudios hace necesario que se investigue acerca de cuáles son los factores que propician esas tendencias. En ese marco,  el proyecto de investigación ?Que sí que no, este camino elijo yo??un estudio de las trayectorias estudiantiles universitarias, se plantea entre sus objetivos identificar componentes, rasgos, en los modos de transitar el recorrido académico, indagando sobre intereses, dificultades y facilidades vivenciados en las experiencias universitarias, así como reconocer ritmos, discontinuidades, regularidades en el rendimiento académico del alumno.  Este trabajo propuesto toma como insumo resultados alcanzados en estudios anteriores realizados en  el ámbito de la Universidad Nacional de San Juan acerca de las prácticas docentes y la formación de grado de estudiantes. Esta ponencia procura centrarse en un análisis cualitativo de las trayectorias, se opta por ubicar al alumno en un momento de su trayectoria universitaria en nuestro estudio, el año 2011 y observar restrospectivamente cuál ha sido su recorrido en relación al currículo prescripto por la carrera y el tiempo de realización del mismo. Nos ocupamos de la lectura comprensiva de su trayectoria,  de la dimensión simbólica e ilustramos con el análisis e interpretación de un caso.","palabras_clave":"Trayectoria académica|Rendimiento|Tiempo|Espacio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84655,"idioma_id":5,"titulo":"Aporte y Descomposición de hojas y re absorción de N, P y K en un bosque primario de Schinopsis Balansae Engler con y sin manejo silvopastoril en el Parque Chaqueño Humedo","resumen":"RESUMEN: El objetivo del trabajo fue estudiar: i) el aporte al suelo de la hojarasca proveniente de árbo-les de Schinopsis balansae Engler, la tasa de descomposición de sus hojas en un bosque primario y con manejo silvopastoril y iii) la relación entre la composición de N, P y K en hojas verdes y secas de esta especie forestal en ambos ecosistemas forestales. Se seleccionaron dos sitios, uno en un monte na-tivo de S. balansae Engler sin intervención humana (MN); y el otro sitio, en un bosque similar sujeto a un manejo silvopastoril (SP). Las hojas senescentes se recolectaron mensualmente en canastos y simul-táneamente se muestreaban las hojas verdes de cada árbol. Posteriormente se lavaban, secaban a 70 °C y se realizaron los análisis de N, P y K foliares. Se detectó que los diferentes tratamientos no impacta-ron negativamente en el aporte de hojarasca al suelo. Las constantes de descomposición (k) fueron 0,10 año-1 en MN y 0,12 año´ en SP, no detectándose diferencias entre los sitios. Se obtuvieron menores concentraciones de N, P, y K en las hojas senescentes con respecto a las hojas verdes, indicando una re-absorción de los mismos. Las mayores concentraciones foliares registradas, siguen el orden P > N > K. ABSTRACT: The aim of this work was to study: i) the leaf-litter production and decomposition of a for-est dominated by Schinopsis balansae Engler trees in the Parque Chaqueño Húmedo; and ii) nitrogen, phosphorns, and potassium concentration relationships between fresh and abscised leaves in two forest stands managed differently. The studied sites were located in primary forest (MN) and the other under silvopastoral management (SP) of S. balansae Engler. Leaf litter produced was monthly collected in traps and at the same time, samples of green leaves of each trees were taken. The N, P, K foliar anal-yses were carried out, Different treatments not impacted negatively in the contribution of litterfall to the soil. Constants of decomposition (k) were 0,10 yeafi in MN and 0,12 year´ in SP. No differences between the sites were detected. Lower concentrations of N, P, and K in senescent leaves with respect to green leaves were registered, indicating a reabsorption of them were obtained. The high foliar con-centrations recorded, follow the orden P > N > K. Palabras claves: Aporte, descomposición, hojarasca, bioelementos, Schinopsis balansae Engler. Key words: Contribution, decomposition, leaf litter, bioelements, Schinopsis balansae Engler.","palabras_clave":"Aporte |descomposicion|hojarasca|bioelementos, Schinopsis balansae Engler"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84663,"idioma_id":4,"titulo":"ANTIOXIDANT CAPACITY OF STRAWBERRY POLYPHENOLS FROM TUCUMAN","resumen":"Free radicáis are generated in the body by normal metabolic activity as well as by lifestyle factors such as smoking, exercise and diet and have been associated in the causation and progression of several chronic diseases. The aim of this work was to investígate the antioxidant capacity of two varieties of strawberry juices and their relationship with phenolic compound contení. Total phenolics concentration was determined by the procedure of Singleton and Rossi while flavonoid and phenolic acids concentration was determined by the method of Zoecklein (1990). Antioxidant activity was determined by FRAP, DPPH and ABTS methods in juices and puré phenolic compounds. Total phenolic concentrations in Albion and Camarosa juices were 1188.4 and 1257.7 mg GAE\/1, respectively. The clarification process was effective to remove approximately 80% of the phenolic compounds. In both juices, the flavonoid fraction was about 75% higher than the phenolic acid fraction. The juice of boths strawberry varieties showed high ferric reducing power as well as ABTS and DPPH radical scavenging activity. Gallie acid showed the highest antioxidant activity among individual compounds. Our results indícate that phenolic compounds are the major contributors of these capacities and suggest that these juices could be proposed as new sources of safe natural antioxidants.","palabras_clave":"ANTIOXIDANT CAPACITY|STRAWBERRY|POLYPHENOLS |TUCUMAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":84947,"idioma_id":5,"titulo":"La novela no-ve-la realidad salvo que sea Rulfo quien la escriba?. Novela y humor en América Latina.?","resumen":"Comicidad,  humorismo y conciencia irónica pertenecen a órdenes heterogéneos pero  implicados. Lo que imbrica a estas nociones, sin embargo, es la capacidad para  violentar las reglas que conforman lo real, intuyendo así una armonía  diferente. El humor ha logrado mediante la suspensión de la ?realidad  predominante? crear otros mundos verbales que amortiguan la dureza de la  realidad injusta, asimismo ha sido un factor dominante en la revisión de la  historia americana, ya que mediante el recurso de la parodia, la sátira, la  carnavalización ha desmitificado el panteón heroico de nuestra historia.","palabras_clave":"humor| conciencia irónica|narrativa latinoamericana"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85169,"idioma_id":5,"titulo":"Competitividad universitaria y coordinación inter-MERCOSUR","resumen":"La competitividad ha sido profusamente abordada, con hincapié en causas complejas y múltiples que explican el grado alcanzado por organizaciones y países. Esto generó definiciones, como: paradigmas, cadenas de valor o ventajas competitivas, con difusión literaria, interpretación de contextos y elaboración de políticas, especialmente para fundamentar incentivos y\/o controles al comercio internacional.  Ante la vastedad del término de competitividad, resulta útil orientarlo hacia sistemas de educación superior, bajo la hipótesis de que mejoraría el desempeño de entes educativos, optimizaría sus recursos, procesos y  resultados, además de permitir comparaciones internacionales más objetivas. Al efecto, se requiere una  definición cualitativo-cuantitativa de la competitividad  universitaria, complementando la  necesaria armonización de políticas en el MERCOSUR.  Para precisar los componentes de dicha competitividad  se procedió a: definir las grandes variables y sus  enfoques explicativos, desagregar sus determinantes y obtener indicadores preliminares. Luego de esto, correspondería interpretar indicadores, extraer  conclusiones y - eventualmente - plantear modelos de simulación con análisis de sensibilidad.  Se aspira al aporte a diagnósticos en los sistemas de educación superior del MERCOSUR, a la calidad en sus procesos y resultados y a una fructífera competitividad universitaria que acompañe la coordinación de estrategias y políticas regionales.","palabras_clave":"MERCOSUR|UNIVERSIDADES|COMPETITIVIDAD|INDICADORES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85236,"idioma_id":10,"titulo":"Effect of yeast cell wall on the performance of broiler chickens intoxicated with aflatoxin B1","resumen":"Micotoxinas são metabólitos secundários produzidos por diversos fungos filamentosos, tóxicos à animais e ao homem por contato, inalação e principalmente ingestão. Aflatoxinas são micotoxinas hepatotóxicas e carcinogênicas, produzidas principalmente pelos fungos Aspergillus flavus e A. parasiticus, e sua presença constitui grande preocupação para a avicultura mundial por problemas como diminuição da produtividade das aves e lesões de carcaça. Adsorventes à base de parede celular da levedura Saccharomyces cerevisiae, possuem glucomananos esterificadas, e são capazes de ligar-se eficientemente a diversas micotoxinas, como aflatoxinas, fumonisinas e zearalenona.   O objetivo do presente estudo foi o de avaliar o desempenho de um aditivo anti-micotoxinas (AAM) à base de parede de leveduras (PCL), em condição de intoxicação experimental por aflatoxina B1 (AFB1) em frangos de corte até os 21 dias de idade.  A adição de 1,012 mg kg-1 (ppm) de AFB1 na dieta dos frangos de corte no presente estudo foi capaz de alterar negativamente o peso vivo, ganho de peso e conversão alimentar a partir dos 14 dias de idade, e nas mesmas condições experimentais a adição do AAM (0,2%) à base de PCL reverteu tais efeitos. Mais estudos devem ser realizados acerca do assunto para melhor esclarecer o mecanismo de ação destes aditivos na produção animal.","palabras_clave":"chickens |aflatoxin B1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85273,"idioma_id":5,"titulo":"Nuevas Evidencias del papel del Péptido Natriurético Tipo C en la funcionalidad vascular.  Impacto en el conocimiento de los mecanismos fisiopatológicos de la hipertensión arterial.","resumen":"Es ampliamente conocido que la función cardiovascular y la homeostasis hidrosalina son controladas por complejos mecanismos que incluyen diferentes factores estructurales y funcionales. Existen evidencias de que tanto el péptido natriurético tipo C (CNP) como el sistema del óxido   nítrico (NO) se encuentran estrechamente relacionados con  la regulación del tono vascular (Moncada S y Higgs A, 1993; Simon A y col, 2009).   El NO es liberado por el endotelio vascular en respuesta a factores humorales y al aumento en las fuerzas de rozamiento, mientras que el CNP se encuentra marcadamente expresado en células endoteliales y es liberado en respuesta a factores de crecimiento y aumento de fuerzas de rozamiento. En vasos de resistencia coronarios y mesentéricos, el CNP   actúa como el factor hiperpolarizante derivado de endotelio induciendo relajación a través de la interacción con el receptor natriurético tipo C (NPR-C) (Chauhan SD y col, 2003). Brunner y col demostraron además que en la relajación inducida por el CNP sobre los vasos coronarios participa la vía NO-cGMP (Brunner F y col, 2001) promoviendo la activación de protein-kinasas dependientes de cGMP y la fosforilación de proteínas implicadas en la defosforilación de cadenas livianas de la miosina, que es una condición previa para la relajación del músculo liso.   Los efectos celulares del CNP son mediados principalmente por una guanilil-ciclasa (GC) particulada o de membrana acoplada a los receptores natriuréticos tipo B (NPR-B) y por la activación de una adenilil-ciclasa o de una fosfolipasa C (PLC) a través del NPR-C (Arejian M y col, 2009; Anand-Srivastava MB, 2005; Murthy KS y col, 2000).   El NO, en cambio, se une al grupo hemo de una GC soluble o citosólica, con un efecto modulador alostérico sobre la actividad de la enzima, que resulta en un aumento de los niveles de cGMP. Este aumento de la producción de cGMP, similar al producido por el CNP a través de la GC de membrana, lleva a una disminución de los niveles intracelulares de Ca2+ a través de una cascada de múltiples reacciones (Moncada S y col, 1991).","palabras_clave":"Péptido natriurético tipo C|Endotelio|Hipertensión arterial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85303,"idioma_id":4,"titulo":"Somatic cell nuclear transfer: history, future and potential applications in the bubaline species","resumen":"Buffalos, an important domestic species mostly found in tropical and subtropical regions, are a valuable source of meat, milk, hide and work power. The application of cloning technology could provide a tool in the preservation of selected buffalo genetic, and potentially in the production of transgenic animals with improved milk or meat characteristics, development of buffalo genotypes with disease resistance or even produce human pharmaceuticals in buffalo milk. Although there was some controversy over the claim of the world\u2019s first cloned buffalo, the first scientific report was produced by Shi et al. in 2007. Researchers at the Animal Reproduction Institute of the Guangxi University of China reported the world first live births of water buffaloes. In their study, cell cycle synchronization of buffalo fetal fibroblasts and granulosa cells using aphidicholine resulted in forty-two blastocysts transferred into 21 synchronized swamp buffalo recipients. These transfers resulted in 4 recipients confirmed pregnant, one aborted on day 300 of gestation and the remaining recipients delivered three cloned calves after 338-349 days of gestation. These embryos were produced by the traditional, micromanipulator-based nuclear transfer protocol. In a later report (Shah et al., 2008), researchers at the Embryo Biotechnology Laboratory, Animal Biotechnology Center of109 the National Dairy Research Institute of India used the hand made cloning approach (zona-free, without micromanipulators) to produce blastocysts from ear-derived adult fibroblasts. This study reported an impressive 40% blastocyst production for nuclear transfer and 70% for parthenogenic activation when using RVCL embryo culture medium (Research Vitro Cleave medium, Cook®, Australia) and well of well (WoW) culture system. In 2009, Shah et al. also reported establishment of cloned water buffalo pregnancies using the hand made cloning approach. Although no scientific report has been made, the same group made a press release in 2009 (Science News) claiming the birth of India\u2019s first cloned Murrah buffalo calves.","palabras_clave":"Nuclear transfer|Water Buffalo|Intespecies|Biotechnology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85310,"idioma_id":4,"titulo":"Effect of processing on the detectability of pecan proteins assessed by immunological and proteomic tools.","resumen":"The present study evaluates the effect of food processing on the antigenicity of pecan proteins as measured by Enzyme-Linked Immunosorbent Assay (ELISA). In addition, proteomic tools were used to identify potential pecan markers suitable for confirming the presence of pecan proteins in food, and validating new methods developed to detect traces of the commodity. To assess the effects of processing on protein stability and antigenicity, pecan nuts were submitted to heat treatments and extracts were analysed by ELISA, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot. The ELISA method was able to detect pecan traces even after submitting the commodity to rigorous treatments, though these treatments affected the detectability to varying degrees. Proteomic assessment showed that the majority of pecan proteins were matched by homology to walnut proteins, which are more abundantly populated in the protein sequence databases. However, there were a few important exceptions: 7S vicilin, 11S legumin, and putative allergen I1, unambiguously identified as pecan in origin. Interestingly, putative allergen I1 offered unique analytical advantages to be used as a pecan marker for validation and confirmation purposes.","palabras_clave":"Allergens|ELISA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85314,"idioma_id":4,"titulo":"Combination of 1-methylcyclopropene treatment and controlled atmosphere storage retains overall fruit quality and bioactive compounds in mango","resumen":"BACKGROUND: Postharvest application of fungicide prochloraz and hot-water dip are commercially practiced to control postharvest diseases in mangoes. Owing to the increasing consumer demand for organically produced fruit, the search for natural environmentally friendly alternative products and processes has become important for the fruit industry. This study evaluated the combined effect of 1-methylcyclopropene (1-MCP) (500 nL L&#8722;1) and controlled atmosphere storage conditions (CA-1, 5% O2 + 5% CO2 or CA-2, 3% O2 + 8% CO2) on the maintenance of fruit quality and bioactive compounds on hot-water treated mangoes (cv. Kent) during postharvest storage.  RESULTS: In comparison to the1-MCP+CA-1 treatment,1-MCP+CA-2 reduced the incidence of anthracnose, weightandfirmness  loss; delayed the skin and flesh colour development; prevented the increase of soluble solids concentration\/titratable acidity  ratio, ethanol and acetaldehyde content; and maintained the ascorbic acid, carotenoid, total phenolic and flavonoid contents, and antioxidant scavenging activity in hot-water treated mangoes. The untrained panel preferred 1-MCP+CA-2 treated fruit to the fruit subjected to other postharvest treatments adopted in this investigation.  CONCLUSION: Our investigation suggests that the combined effect of 1-MCP and CA-2 storage can be recommended as an alternative treatment to replace prochloraz application for hot-water treated mangoes and can be adopted commercially for organic exportmarkets.","palabras_clave":"Mango"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85388,"idioma_id":4,"titulo":"Chemical study and anti-inflammatory activity of Capsicum chacoense and C. baccatum","resumen":"Capsicum species, Solanaceae, have been used for centuries as food  additives by populations of different regions of the world. Capsaicin (trans-methyl-N-vainillyl-nonenamide) is the main pungent compound extracted from the red hot pepper fruit (Capsicum spp.). The capsaicin content was determined by means of a HPLC method. The results showed that Capsicum chacoense Hunz., contains similar amounts of capsaicin (13.9 mg\/100 g of dry fruit) in comparison with Capsicum baccatum L. (12.6 mg\/100 g) and Capsicum annum L. (10.1 mg\/100 g). Dichloromethane (CH2Cl2) and ethanol (EtOH) extracts of C. chacoense elicited a 46% and 38 % of inhibition on the arachidonic acid (AA) pathway in ear edema respectively while the CH2Cl2 and EtOH extracts of C. baccatum inhibited 52% and 35% the arachidonic acid response respectively.","palabras_clave":"antiinflammatory effect|capsaicin content|Capsicum baccatum|Capsicum chacoense"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85391,"idioma_id":4,"titulo":"SITE-SPECIFIC DIFFERENCES OF TIBIA STRUCTURE IN RUNNERS AND SEDENTARY MEN AND WOMEN","resumen":"Purpose. Study the relationship between mechanical environment and bone structure  by comparing the tibia in people with different physical activity.  Material & Methods. Indicators of bone mass (bone mineral content, BMC), bone tissue 'quality' (cortical volumetric mineral density, vBMD) and diaphyseal design (endocortical and periosteal perimeters, EcPm; PoPm; cortical thickness, CtTh; circularity, Circ; bending and torsion cross-sectional moments of inertia, CSMIs) were determined in serial pQCT scans taken at 5%-steps of the tibia in 40 voluntary men and women aged 25-40 yr who were either following a sedentary life-style or experienced distance runners (n=10\/group). Results. Bone mass and design indicators were higher in runner than in sedentary men, with variable effect size along the tibia. In the distal tibia, runners had enhanced BMC and CtTh (resistance to compression), but EcPm, PoPm, Circ, or CSMI were unaffected. In the midshaft, CSMIs (resistance to bending\/torsion) were enhanced in runners, whilst bone mass was unaffected. In the proximal third, effects were observed for CtTh, EoPm and PoPm. In female runners, these benefits were restricted to CSMIs only. Cortical vBMD, naturally lower in men than in women, was reduced in runners of either sex.  Discussion. Results are coherent with previous findings in sedentarians and with Frost´s Mechanostat Theory. The observed group differences in cortical vBMD could reflect an increase in intra-cortical porosity (enhanced remodeling for damage repair), eventually compensated biomechanically by CSMIs improvements. The sex-specificity Powered by Editorial Manager® and Preprint Manager® from Aries Systems Corporation  of exercise effects may suggest the interference by the endocrine environment. Results confirm that the mechanical environment is a strong determinant of regional tibia structure, and suggest that the endocrine environment may reduce the effects of physical interventions on bone health in fertile women.","palabras_clave":"Exercise and bone|Osteoporosis,|Bone biomechanics|Bone structure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85493,"idioma_id":5,"titulo":"Las razones de la amplia procedencia de la prisión preventiva a fines del siglo XIX: Una mirada a través del análisis de la administración judicial en la provincia de Buenos Aires (1877-1906)","resumen":"A fines del siglo XIX se codificó el derecho penal en la Argentina con el propósito de brindar mayor seguridad jurídica, a su vez, se reguló de manera amplia la procedencia de la prisión preventiva del imputado durante el proceso.  A pesar de lo lesiva que era esta medida cautelar no se dictaron políticas tendientes a restringir su uso. Este artículo se detiene en el análisis de la administración judicial en la provincia de Buenos Aires y en los debates de la legislatura provincial a fin de ilustrar las dificultades de las autoridades políticas para encontrar un equilibrio entre la protección de la libertad individual y la preservación de la seguridad pública. Precisamente, el objetivo del trabajo se centra en  identificar las razones que explican la amplia legitimidad que gozó la prisión preventiva en las elites políticas.","palabras_clave":"prisión preventiva|praxis judicial|provincia de Buenos Aires|siglo XIX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85509,"idioma_id":5,"titulo":"De los Andes al mar","resumen":"La cultura, lo simbólico, ese poder de hacer cosas con palabras (con imágenes, sonidos, formas) no existe por fuera de la materialidad de la historia. No puede pensarse por separado. Cultura y política: un amasado que sólo desde una miopía intencionada puede ser diseccionado en partes que nunca son, además, equivalentes.   Maíz es una revista desde la hechura de las palabras y las cosas, con la alegría oceánica de haber sido parida en unos días de extraña felicidad para los compromisos. De las convicciones. De la apuesta común a correr en el río de  los que han sido acallados, olvidados, condenados. Para abrir otra historia. Otras historias en un solo mundo de muchas voces.","palabras_clave":"CULTURA|POLÍTICA|PALABRAS|COMPROMISO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85533,"idioma_id":5,"titulo":"Otra vuelta de leva a la noción de operaciones","resumen":"El recorrido que propongo tiene el objetivo de explorar una aproximación que concilia la capacidad empírica para el abordaje de materiales concretos y la capacidad formal para describirlos a partir de un modelo que, a diferencia de los derivados de lógica y la lingüística tradicionales (consagrados gracias a la implantación de  métodos descriptivos y clasificatorios) se ocupa de las condiciones de empleo del lenguaje.      El propósito de este trabajo es, entonces, tratar de hilvanar algunos puntos de una teoría notablemente original y que asombrosamente no ha tenido la merecida difusión en Argentina, considerando que Antoine Culioli es uno de los nombres más importantes de la lingüística del siglo XX e inspirador de una generación de reconocidos lingüistas, semiólogos, lógicos, psicólogos, antropólogos e investigadores de múltiples campos.","palabras_clave":"OPERACIONES|ENUNCIACIÒN|REFERENCIACIÒN|REPRESENTACIÒN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85567,"idioma_id":5,"titulo":"El sistema de solución de controversias de la Convención de Naciones Unidas sobre el Derecho del Mar ante el caso de la Fragata A.R.A. Libertad","resumen":"A 200 años del Schooner Exchange , la inmunidad de los buques vuelve a estar en la tapa del debate especializado, tanto es así, que la situación jurídica de la Fragata ARA Libertad en los tribunales ghaneses y en el ámbito internacional ha adquirido también una gran repercusión en los medios de prensa, especialmente a partir de la segunda semana de noviembre del corriente año, debido a la solicitud de medidas provisionales que ha presentado la República Argentina en el Tribunal Internacional de Derecho del Mar (o Tribunal de Hamburgo, indistintamente) , una alternativa especializada de solución de controversias instituida por la Convención de Naciones Unidas sobre Derecho del Mar (en adelante ?la Convención?) la que, asimismo, regula 25 temas y cuestiones que abarcan distintos aspectos de los usos y recursos del mar, destacándose su Parte XV, referida precisamente a los mecanismos de solución obligatoria de controversias, que crea y dispone el modo de acceder al Tribunal de Hamburgo  en su art. 287, junto al Anexo VI de la misma Convención.  El objetivo del presente trabajo es presentar las principales características que posee éste tribunal internacional e identificar algunas cuestiones relevantes que podrían llegar a considerarse en relación a la solicitud de medidas provisionales presentada por Argentina y adelantar un posible escenario respecto de una cuestión de fondo que, como veremos más adelante, se va a resolver mediante una solución arbitral conforme el Anexo VII de la Convención.","palabras_clave":"Derecho del Mar|Solución de Controversias|Tribunal de Hamburgo|Fragata Libertad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85757,"idioma_id":5,"titulo":"Tratamiento de un Herbicida Comercial por el Proceso Foto-Fenton","resumen":"xx","palabras_clave":"Foto-Fenton|Energía solar"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85758,"idioma_id":5,"titulo":"Mineralización del Herbicida Comercial 2,4-D Amina en Laboratorio y en Reactor Solar a Escala Piloto","resumen":"xx","palabras_clave":"Foto-fenton |Energía solar"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85760,"idioma_id":5,"titulo":"Reducción del Consumo Energético y de la Emisión de Gases en Instalaciones para el Calentamiento Solar de Agua","resumen":"xx","palabras_clave":"Energía solar|Colectores solares"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85909,"idioma_id":4,"titulo":"Quantum Dot Based Heterostructures for Unassisted  Photoelectrochemical Hydrogen Generation","resumen":"TiO  2  hollow nanowires (HNWs) and nanoparticles (NPs) constitute prom-  ising architectures for QDs sensitized photoanodes for H  2  generation. We   sensitize these structures with CdS\/CdSe quantum dots by two different   methods (chemical bath deposition, CBD and succesive ionic layer adsorp-  tion and reaction, SILAR) and evaluate the performance of these photoelec-  trodes. Remarkable photocurrents of 4 mA · cm and 8 mA · cm     &#8722; 2  and hydrogen   generation rates of 40 ml · cm     &#8722; 2  · day     &#8722; 1  and 80 ml · cm     &#8722; 2  · day     &#8722; 1  have been   obtained in a three electrode con&#64257;  guration with sacri&#64257;  cial hole scavengers   (Na  2 S and Na  2 SO  3 ), for HNWs and NPs respectively, which is con&#64257;  rmed   through gas analysis. More importantly, autonomous generation of H  2    (20 ml · cm     &#8722; 2  · day     &#8722; 1  corresponding to 2 mA · cm     &#8722; 2  photocurrent) is obtained in   a two electrode con&#64257;  guration at short circuit under 100 mW · cm     &#8722; 2  illumina-  tion, clearly showing that these photoanodes can produce hydrogen without   the assistance of any external bias. To the best of the authors? knowledge,   this is the highest unbiased solar H  2  generation rate reported for these of   QDs based heterostructures. Impedance spectroscopy measurements show   similar electron density of trap states below the TiO  2  conduction band while   the recombination resistance was higher for HNWs, consistently with the   much lower surface area compared to NPs. However, the conductivity of   both structures is similar, in spite of the one dimensional character of HNWs,   which leaves some room for improvement of these nanowired structures. The   effect of the QDs deposition method is also evaluated. Both structures show   remarkable stability without any appreciable photocurrent loss after 0.5 hour   of operation. The &#64257;  ndings of this study constitute a relevant step towards   the feasibility of hydrogen generation with wide bandgap semiconductors\/  quantum dots based heterostructures.","palabras_clave":"TiO2  hollow nanowires|QDs sensitized photoanodes|H2  generation|CdS\/CdSe quantum dots"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85981,"idioma_id":5,"titulo":"La práctica del futuro abogado en la Facultad de Derecho de la Universidad Nacional Autónoma de México (UNAM)","resumen":"En la UNAM , la Práctica Profesional forma parte de las materias que integran el Plan de Estudios a nivel Licenciatura en la Facultad de Derecho, a través de su 'Laboratorio de Enseñanza Práctica de Derecho' (LEPDER). Las actividades se enfocan básica y enunciativamente en lo siguiente:   -Clases en el salón a través de un miembro del Tribunal Superior de Justicia del D.F. y un Maestro titular de la cátedra.-  -Prácticas profesionales presenciales en alguno de los Juzgados que forman parte del Tribunal Superior de Justicia del D.F.-  -Un ciclo permanente de conferencias sabatinas intituladas 'Temas Selectos de Derecho Procesal'.-  -Intercambios académicos con Universidades Nacionales y del Extranjero.-     A su vez, la Facultad de Derecho de la (UNAM), a través del Laboratorio de Enseñanza Práctica de Derecho (LEPDER), participa en la serie televisiva intitulada 'Mirador Universitario' que organiza la Coordinación de Universidad Abierta y Educación a Distancia (CUAED),","palabras_clave":"PRACTICA|ELDIAL|VALLET|UNAM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":85985,"idioma_id":5,"titulo":"Interesante caso sobre delito de usurpación, llevado por el Patrocinio Jurídico Gratuito de la Facultad de Derecho de la UBA","resumen":"Dentro del trabajo de nuestro Centro de formación Profesional ?popularmente conocido como 'el Práctico...'-, presentamos hoy a los lectores el caso planteado por la Sra. Martha Ofelia Suárez, el cual fuera llevado adelante por la Comisión nro. 1169 de la Dra. Patricia Parasporo, conjuntamente con sus alumnos y ayudantes. La Sra. Suárez había sido denunciada en orden a lo dispuesto por el artículo 181 inciso 1ero. CP ?usurpación-.     La estrategia de defensa se centró en argumentar que la conducta de Suárez resultó ser atípica en orden al delito imputado. Tal conducta transitó no respecto del ingreso y despojo de la finca, sino que se desarrolló respecto de la permanencia en el sitio, más allá del término acordado verbalmente por las partes.-","palabras_clave":"CASO|USURPACION|PATROCINIO |VALLET"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86004,"idioma_id":5,"titulo":"Precipitación y bordes de grano en aleaciones CuAlBe","resumen":"Se estudian transformaciones de fase en aleaciones CuAlBe mono y policristalinas, poniendo especial énfasis en el efecto de los bordes de grano.","palabras_clave":"transformaciones de fase|aleaciones CuAlBe|borde de grano"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86006,"idioma_id":5,"titulo":"LA MICROSCOPIA ÓPTICA COMO HERRAMIENTA PARA EL ESTUDIO DE LA SOLIDIFICACIÓN UNIDIRECCIONAL DE ALEACIONES ZnAl","resumen":"Para estudiar el proceso de solidificación del sistema Al Zn se crecieron unidireccionalmente muestras de composición hipo-eutéctica de Zn-0,5 %Al en peso, por debajo del límite de solubilidad y por encima Zn-2 y 4 %Al en peso, e hipereutecticas Zn - 8%Al en peso. Estas aleaciones presentan comportamientos totalmente diferentes, caracterizados por su distinto camino de solidificación. Esto resulta en microestructuras con distintas fases primarias y donde el líquido intercelular puede terminar la solidificación en composición eutéctica sólo en el caso de composición por encima del límite de solubilidad total de 1,25%Al en peso.","palabras_clave":"solidificacion unidireccional|aleaciones diluidas AlZn|microscopia optica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86016,"idioma_id":4,"titulo":"Stereo regions-of-interest selection for pedestrian protection: A survey","resumen":"Vision-based pedestrian detection for intelligent vehicles applications is a crucial andactive research area due to the essential benefits in terms of reducing the number of acci-dents involving pedestrians and vehicles. During the last decade a considerable amount ofresearch studies have been proposed, filling the gap between prototypes and commercialimplementations. Pedestrian detection systems can be roughly divided into three main dif-ferent sub-parts: Region Of Interest ? ROI ? selection, classification and tracking. Previous sur-veys have covered the literature in a holistic way. An example would be, analyzing all thesolutions proposed for all the stages and including higher level analysis, but in most casesthey give more emphasis to the classification stage. Due to the difficulty of this detectiontask, the variety of solutions, sensor configurations (monocular\/stereo; visible\/infrared)available in the literature, we propose to break down the variability of the problem by pro-viding exhaustive review of one specific stage: stereo-based ROI selection. ROI selection is akey component that has to be designed to provide generic obstacles at lowest false nega-tive rate and maintain a low number of false positives. The number of missed pedestrianshas to be approximately equal to 0 since a pedestrian missed by the ROI selection stagewould not be detected in further stages. In addition, the number of non-pedestrians obsta-cles should be as low as possible to reduce both the number of false alarms and the com-putational costs of further stages. In contrast to monocular approaches, stereo ROI selectiondetermines the relative distance between the pedestrian and the vehicle, assuring that thereported candidates are related with real physical objects. The stereo-based ROI selectionstep is also divided into different components that are independently analyzed, increasingvisibility for future proposals and developments. Discussion is finally presented highlight-ing the current problems for obtaining a global overview of the actual performance of thedifferent approaches and analyzing future trends.","palabras_clave":"PEDESTRIAN DETECTION|REGIONS OF INTEREST SELECTION|INTELLIGENT VEHICLES|INTELLIGENT TRANSPORTATION SYSTEMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86049,"idioma_id":5,"titulo":"Revisando la categoría de intelectual para el anarquismo posterior a 1930. Un estudio de caso a través de Juan Lazarte, 1918- 1963","resumen":"En el presente trabajO nos proponemos colaborar con la ampliación y diversificación de los estudios culturales a través de la indagación de la actividad intelectual de Juan Lazarte, médico anarquista que participó activamente en la vida política, cultural y médica de Argentina y España desde la Reforma Universitaria hasta comienzos de la década del ´60. Para ello, en primer lugar situaremos las diferentes categorías de intelectual que se han esbozado para los intelectuales anarquistas, así como las diversas conceptualizaciones del movimiento. A continuación, nos centraremos en la obra de Juan Lazarte y revisaremos su papel dentro del anarquismo y otros espacios, para  luego definir una categoría de intelectual para el anarquismo posterior a 1930.","palabras_clave":"ANARQUISMO|INTELECTUALES|GREMIALISMO MÉDICO|JUAN LAZARTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86051,"idioma_id":5,"titulo":"La eugenesia bajo la lupa de las investigaciones sociales argentinas","resumen":"Las investigaciones sociales en Argentina sobre el desarrollo de la eugenesia en el país, se han multiplicado en los últimos años. Esta producción ha originado un debate sobre los alcances y fines de la eugenesia según los diversos anclajes teóricos y metodológicos de los distintos estudios.  En este trabajo nos proponemos realizar un primer relevamiento sobre las diversas posturas, a fin de contextualizar y redimensionar nuestro análisis centrado en el discurso anarquista sobre maternidad consciente y voluntaria, obtenida a través de las herramientas anticoncepcionales.  Concentrados en el análisis de  la eugenesia ideada e implementada por los sectores de poder, las producciones locales, han visibilizado exiguamente la eugenesia en espacios contrahegemónicos. Nuestra hipótesis es que, al enfocar las lecturas realizadas por el anarquismo, la eugenesia se inscribe en una matriz distinta que la que propiciaron las posturas acendradas en lugares de poder, especialmente, el ámbito médico.","palabras_clave":"EUGENESIA|ARGENTINA|DEBATE|ANARQUISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86055,"idioma_id":5,"titulo":"Apuntes sobre la eugenesia y la libertad sexual en el discurso de dos médicos anarquistas. Argentina, 1930-1940","resumen":"En este trabajo nos interesa indagar dos cuestiones que han sido estudiadas en relación con los discursos hegemónicos, la eugenesia y su incumbencia en la construcción de un modelo de sexualidad femenina, pero que han sido exiguamente investigadas en otras locuciones. Por ello, aquí analizaremos el discurso eugénico y neomalthusiano anarquista con la intención de situarlo como una locución que, a diferencia de las hegemónicas, propició la libertad sexual de las mujeres.   Nos centraremos para ello en las producciones de dos médicos anarquistas que, con gran despliegue hasta la segunda mitad del siglo XX, actuaron dentro del movimiento anarquista nacional e internacional. Estos médicos, lejos de las ideas predominantes de la época, defendieron propuestas innovadoras sobre la educación sexual, el control de la natalidad, la maternidad consciente y voluntaria y la libertad sexual de las mujeres.","palabras_clave":"EUGENESIA|ANARQUISMO|LIBERTAD SEXUAL|DISCURSO MÉDICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86065,"idioma_id":5,"titulo":"INICIATIVA EMPRESARIAL Y PROCESO DE CRECIMIENTO: RETOS Y PERSPECTIVAS","resumen":"El trabajo profundiza en el estudio del proceso de crecimiento de las PYMEs, en particular las de base tecnológica, y capta desde el área cubierta de revisión de la literatura más reciente particularidades relacionadas a sus factores asociados, específicamente aquellos vinculados a los conocimientos y capacidades de aprendizajes, Los hallazgos destacan la naturaleza situada, compleja  e idiosincrásica del crecimiento de las empresas pequeñas y las tensiones entre esta experiencia y una visión prevaleciente en la investigación existente del conocimiento como un activo codificable y transferible. La necesidad de una heurística complementaria para pequeñas empresas, nuevas formas de entender el conocimiento -no solo como un activo- y nuevos enfoques de investigación se identifican para entender mejor la heterogeneidad que plantea el fenómeno.","palabras_clave":"INICIATIVA|EMPRESARIAL|CRECIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86123,"idioma_id":5,"titulo":"Aportes de la investigación musicológica a la creación de un cancionero escolar argentino","resumen":"La técnica  compositiva  del  repertorio  patrio  echa  sus  raíces  en  el  universo  discursivo  del estilo occidental del modelo europeizante sobre el que se construyó el proyecto nacional, reservándole un lugar destacado al repertorio folklórico en una amplia gama que va desdrecopilaciones  propiamente  folklóricas  a  formas  diversas  de  proyección,  muchas  de  las cuales echan raíces en la música académica.   ","palabras_clave":"Investigación musicologica|cancionero escolar|sistema educativo argentino"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86133,"idioma_id":5,"titulo":"El lugar del cancionero folklórico en el repertorio escolar  durante la primera mitad del siglo XX","resumen":"El folklore, en sus diversas manifestaciones, especialmente música y danzas, ha acompañado las clases  de  música  y  los  actos  patrios  durante  la  escolarización  de  los  argentinos,  siendo  parte importante   del   repertorio,   ya   sea   indicado   desde   el   Ministerio   de   Educación,   así   como seleccionado  por  los  docentes  de  música.    La  canción  es  un  resorte  muy  fuerte  dentro  de  la formación de la nacionalidad, ya que posee una doble acción  en la que el significado del discurso poético  se  potencia  por  el  significado  de  la  música,  de  aquí  el  valor  discursivo  del  cancionero folklórico en la  construcción de la identidad nacional.          Esta  investigación  se  propone  indagar  acerca  del  lugar  que  ha  ocupado  el  repertorio  folklórico           escolar  en  el  sistema  educativo  argentino  en  la  primera  mitad  del  siglo  XX  en  relación  a  la construcción de la identidad nacional.","palabras_clave":"Cancionero folklórico|repertorio escolar|sistema educativo argentino|politicas culturales|identidad nacional"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86263,"idioma_id":5,"titulo":"Desarrollo de la alfabetización académica en aulas de ingeniería. Un aporte desde la LSF","resumen":"El propósito de este trabajo es mostrar las conclusiones de una   experiencia de enseñanza de habilidades discursivas, en el marco de un   proyecto de investigación interdisciplinario que se ha llevado a cabo en   el seno de las cátedras Comunicación Oral y Escrita y Química   General de la Facultad de Ingeniería y Ciencias Hídricas (FICH) de la   Universidad Nacional del Litoral. El trabajo se basa en la teoría de   género y registro desarrollada por la Escuela de Sydney en el marco de   la Lingüística Sistémico Funcional (LSF) y sus aplicaciones   educacionales. Los resultados en términos del manejo de las herramientas   lingüísticas por parte de los estudiantes fueron medidos cualitativa y   cuantitativamente.","palabras_clave":"ALFABETIZACIÓN ACADÉMICA|DISCURSO |INGENIERÍA|LINGÜISTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86281,"idioma_id":5,"titulo":"De la prisión preventiva al campo del control del delito en la provincia de Buenos Aires: algunas reconfiguraciones","resumen":"Una primera línea de trabajos que presentaremos respecto  de la prisión preventiva  es aquella proveniente de la ciencia o  dogmática jurídica. Esta línea de indagación se preocupa por denunciar el  incumplimiento de aquello que debería suceder si el derecho legislado se  aplicara cabalmente. Precisemos frugalmente qué sostienen las normas legales respecto  a la PP. La segunda  propuesta es ciertamente sencilla: tratar de cruzar algunos aportes  provenientes de los estudios culturales (EC) británicos con la administración  de justicia. Y más específicamente, ligar un concepto, el de estructura de  sentimiento (ES), con una práctica judicial compleja, como lo es la PP; utilizar el primero para  lograr una comprensión más convincente de la segunda. Otra estrategia para  reflexionar acerca de la PP,  o al menos para no hacerlo simplemente desde la ingeniería abstracta del  sistema jurídico, es tomarla como una práctica a la que es posible escrutar a  partir de la administración de justicia penal, que es a su vez la que le da su  condición de posibilidad, considerando a sus operadores ni plenamente libres de  los condicionamientos de la organización en la que se desempeñan, ni autómatas  que carecen por completo de la facultad de elección. En síntesis, desmenuzar el  problema a partir de un criterio praxeológico.  Luego de lo dicho acerca de la PP,  ésta parece desperezarse en un nuevo dispositivo. Desde mediados de 2005 se está llevando  adelante en la Provincia  de Buenos Aires un proceso de fortalecimiento del sistema acusatorio  que tuvo como puntapié inicial el Plan piloto realizado en el Departamento  Judicial de Mar del Plata. Algunos de sus principales objetivos han sido  promover el vigor de las garantías constitucionales junto con las normas del  debido proceso, para así mejorar el modelo y la capacidad de servicio de  respuesta del sistema penal en torno a los distintos conflictos. Para  avanzar sobre esto es imprescindible pensar relacionalmente los elementos: PP,  proceso de flagrancia, velocidad, visibilidad, etc., deberían estimarse  producto ?y productores- de una configuración más amplia de vinculaciones en  torno a un campo concreto: el campo del control del delito.","palabras_clave":"PRISION |PREVENTIVA|CAMPO|CONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86456,"idioma_id":5,"titulo":"El bien común político en John Finnis","resumen":"John Finnis considera que la paz y la justicia son las únicas finalidades del bien común político. Más aún, el citado profesor australiano sostiene que el bien común político excluye de la «res publica» a toda forma de perfeccionamiento ético de los ciudadanos. Tal interpretación fue rechazada por autores como Sergio Castaño y Camilo Tale. En este orden de ideas, el presente trabajo se dirige a efectuar una contribución al debate Castaño-Finnis, mediante una respuesta a la siguiente pregunta: ¿cómo se vincula el bien común político con el perfeccionamiento ético de los ciudadanos en la teoría de J. M. Finnis? Se brindará una respuesta a tal interrogante al hilo de las siguientes cuestiones: 1) descripción de los principales textos de J. M. Finnis en que desarrolla su tesis sobre el bien común político; 2) balance crítico sobre la exclusión del perfeccionamiento ético del bien común político y, finalmente, 3) conclusiones.","palabras_clave":"Justicia|Perfeccionamiento ético|Gobierno|Paz|Derecho"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86465,"idioma_id":5,"titulo":"Redes intelectuales y recepción en la cultura jurídico penal de Córdoba (1900-1950)","resumen":"El propósito de este artículo es analizar los factores que contribuyeron al abandono de la doctrina científica del positivismo criminológico en el ámbito de la cultura jurídica de Córdoba a partir de 1926. Con ese objeto, y a partir de las categorías de la historia intelectual, se analizará la conformación de una élite intelectual, conformada por juristas europeos (Luis Jiménez de Asúa, Marcello Finzi y Roberto Goldschmidt), y su relación con juristas locales (Enrique Martínez Paz, Sebastián Soler y Ricardo Núñez). A partir de ese contacto, y en el ámbito del Instituto de Derecho Comparado de la Facultad de Derecho de la Universidad de Córdoba, comenzó un proceso de recepción de la dogmática analítica de la teoría del delito que vino a sustituir el modelo epistemológico del positivismo. En este proceso, se analiza, especialmente, la traducción de obras relevantes de la ciencia jurídica alemana y su difusión a través de empresas editoriales locales.","palabras_clave":"REDES INTELECTUALES|CULTURA JURIDICA|CORDOBA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86524,"idioma_id":4,"titulo":"Variable Population MOPSO applied to Medical Visits","resumen":"Multi-objective optimization techniques are the ideal support tools for the decision-making process. They provide a set of optimal solutions for each of the significant aspects of the problem, thus summarizing the alternatives to be considered. Having a limited number of alternatives makes it easier for decision makers to perform their tasks, since they can focus their efforts towards the analysis of the available options. In this paper, the main characteristics of multi-objective optimization are summarized, and a real experience is described regarding the optimization of mobile units assignment at a health care company in Argentina using a new method based on swarm intelligence called varMOPSO.","palabras_clave":"Evolutionary Computation|Swarm Intelligence|Multi-objective function optimization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86601,"idioma_id":5,"titulo":"Los cursos de ingreso: ¿barrera o trampolín? Una experiencia de lectura y escritura en el ingreso a la carrera de Historia","resumen":"El ingreso a la Universidad supone la incorporación de un amplio conjunto de habilidades que serán evaluadas y de las cuáles dependerá el éxito o no en la carrera. ¿Qué sucede con los estudiantes qué ingresan sin esas habilidades? ¿Deben fracasar o las pueden aprender? ¿Qué rol ocupan los docentes en esta experiencia? Existen un conjunto amplio de factores que se pueden tener en cuenta a la hora de trabajar esas habilidades en clase y en las devoluciones a sus escritos, que ayuden a un estudiante a superarse y empezar a encontrar un camino propio dentro de la Universidad. El objetivo de este ensayo es presentar la experiencia de un estudiante particular en la realización de sus primeros trabajos en la Universidad, en una comisión que me tuvo a mí como profesor.","palabras_clave":"Lectura|Escritura|Ingreso Universitario|Evaluación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86731,"idioma_id":5,"titulo":"ENFERMEDADES PARASITARIAS TRANSMITIDAS POR ALIMENTOS EPTA OCASIONADAS POR NEMATODES DE LA CLASE ENOPLEA","resumen":"Suelo y aguas resultan frecuentemente contaminados con heces conteniendoestadíos de diseminación parasitaria provenientes de distintas especiesde animales domésticos y del hombre. No debe menospreciarse la contaminaciónque producen las distintas especies de animales silvestres.Así, el suelo actúa como el principal reservorio de huevos y larvas de distintosnematodos parásitos capaces de afectar la salud del hombre y de los animales.En él permanecen viables como formas infectantes durante períodos prolongados.Desde allí contaminar alimentos y determinar EPTA, prevalentes, potencialmentezoonóticas, emergentes o raras. La presencia de invertebrados, hormigas,cucarachas, lombrices de tierra, caracoles, babosas y otros brinda la posibilidadde continuar el ciclo a nematodos heteroxenos.","palabras_clave":"EPTA|FOOD BORNE|DISEASES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86787,"idioma_id":5,"titulo":"Efecto Del Abonado Con Cáscara De Girasol (Helianthus annus L). Sobre Propiedades Del Suelo.","resumen":"Las cáscaras de girasol utilizadas como abono pueden mejorar las propiedades físicas y químicas del suelo. Se realizó un ensayo consistente en la incorporación de 0 (A0); 55 (A1) y 88 (A2) Mg ha-1 de cáscaras en la capa arable de un Haplustol Típico. Luego de 52 meses de incorporadas las cáscaras perduró un fuerte incremento del carbono orgánico (CO) en A1 (15,5) y A2: (16,6) g kg-1 respecto de A0 (11,6 g kg-1). El pH descendió de 7,5 en A0 a 7,3 en A1 y A2. El P continuó alto después de 52 meses en los tratamientos A1 (21 mg kg-1) y A2 (27 mg kg-1) respecto A0 (18 mg kg-1). La estabilidad estructural a los 40 y 52 meses alcanzó los mayores valores para A1 y A2 con respecto de A0. Al finalizar el ensayo los valores de agua retenida a 0,01 MPa fueron 30% superiores al testigo, y a 0,033 MPa fueron 23% más altos que A0; a la tensión de 1,5 MPa no hubo diferencia significativa entre tratamientos. El agua útil de A1 y A2 mostró diferencias significativas respecto de A0. En base a los resultados obtenidos con la incorporación de este residuo se considera recomendable su utilización","palabras_clave":"Residuos orgánicos|Enmiendas lignocelulósicas|Propiedades físicas y químicas del suelo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86843,"idioma_id":5,"titulo":"Estudio sobre actitudes de estudiantes de la carrera de grado de psicología hacia la ética profesional","resumen":"El presente trabajo se enmarca en el proyecto UBACyT 20020100200125 \u201CActitudes de estudiantes universitarios de grado y de posgrado de la Facultad de Psicología de la Universidad de Buenos Aires respecto de la ética profesional. Estudio exploratorio descriptivo en base a una investigación cuali-cuantitativa\u201D dirigida por la Phd. Elizabeth Ormart. El objetivo es profundizar en el conocimiento de las actitudes que presentan los estudiantes universitarios en materia de ética profesional. Para ello, nos servimos de la Escala de Actitudes Éticas de Hirsch et al, desarrollada originariamente en castellano y validada en población universitaria española. Esta escala, basada en el modelo de la teoría de la acción razonada de Fishbein y Ajzen (Escámez, 1988 y 1991), está compuesta por 55 proposiciones referidas a cuatro competencias relacionadas con el profesionalismo. Se presenta el análisis de los datos cuantitativos obtenidos a partir de las encuestas realizadas a 216 estudiantes de ambos sexos pertenecientes a la Facultad de Psicología de la UBA. La edad de los estudiantes oscila entre los 26 y los 53 años de edad.  En las conclusiones se destaca que los estudiantes de la carrera de psicología de la UBA valoran en primer lugar las competencias cognitivas y técnicas y en segundo lugar las competencias éticas.","palabras_clave":"COMPTENCIAS|ACTITUDES|ÉTICA|ESTUDIANTES UNIVERSITARIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":86951,"idioma_id":5,"titulo":"Evaluación cualitativa continua de un programa de intervención en Habilidades sociales","resumen":"Las Habilidades sociales forman parte de las Habilidades para la vida y se consideran estrategias eficaces para la promoción de salud y prevención de la drogodependencia, empleadas actualmente desde diferentes programas aplicados en países de Latinoamérica (OPS, 2001; Botvin, Griffin, Diaz y Ifill-Williams, 2001), como factores protectores ante múltiples situaciones de riesgo (Cardozo, Dubini, Ardiles y Fantino, 2009). Durante el 2009 hemos implementado un programa de intervención en habilidades sociales donde participaron 350 adolescentes escolarizados pertenecientes a escuelas públicas de nivel medio de la ciudad de Córdoba. La intervención surge a partir de la demanda de la Secretaría de Coordinación en la Prevención del Consumo de la Provincia de Córdoba para abordar la problemática del consumo de sustancias en los adolescentes escolarizados. &nbsp;Reconociendo los escasos estudios que llevan a cabo evaluaciones cualitativas en las intervenciones en habilidades psicosociales, en el presente trabajo exponemos los resultados finales de la evaluación cualitativa continua de la experiencia realizada. Realizamos un análisis cualitativo interpretativo de diferentes unidades de análisis. &nbsp;","palabras_clave":"Habilidades para la Vida|Consumo de Sustancias|Adolescentes escolarizados"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87160,"idioma_id":5,"titulo":"El arte del ladrón: las traducciones de poesía de María Negroni","resumen":"El arte del ladrón: las traducciones de poesía de María Negroni","palabras_clave":"POESIA|TRADUCCIÓN|NEGRONI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87191,"idioma_id":5,"titulo":"Dinámica histórica regional y el surgimiento de ámbitos jurídicos de referencia internacional. Manuel de Juano y el Derecho Tributario Interamericano","resumen":"Revista Indizada INTEGRA EL CATALOGO LATINDEX-RED DE CLASIFICACIÓN INTEGRADA DE REVISTAS CIENTÍFICAS- REBIUN Y DIALNET. Revista editada por el Núcleo de Derecho Civil. Grupo de Investigación de la Universidad de la República con Registro en el Pro Rectorado de Investigación y en  CSIC. La dinámica de las ciudades puertos regionales inciden en la identidad de sus universidades, en la trama de las redes académicas establecidas con otros centros, en el grado de transferencia del saber adquirido a la sociedad y en la concreción de propuestas superadoras. El surgimiento de las Facultades de Derecho en Rosario fue el  resultado de un secular proceso que involucró a la dirigencia local, el foro y una notable generación de intelectuales, y que pudo irrumpir en una 'revolución' contextual. La puja por áreas de influencia económica entre las tres ciudades puertos más importantes del litoral fluvial argentino: Buenos Aires, Rosario y Santa Fe, también se trasladó al terreno de la capacidad legal de otorgar títulos oficialmente reconocidos para el ejercicio profesional y dilataron los anhelos en tal sentido de la entonces segunda ciudad en importancia de la Argentina. Una modificación abrupta de la política nacional, impulsada también por factores económicos y políticos internacionales, facilitó el nacimiento, en 1959, de la Facultad Católica de Derecho de Rosario y la Escuela de Derecho de la Facultad de Ciencias Económicas, Comerciales y Políticas de la ciudad de Rosario (Argentina) dependiente de la Universidad Nacional del Litoral, (luego Facultad de Derecho de la Universidad Nacional de Rosario). La estrecha relación existente entre los juristas uruguayos y los integrantes del foro rosarino fue potenciada por la creación de la Escuela y luego Facultad de Derecho de la Universidad pública. A manera de ejemplo se señala en este artículo la relación entre los tributaristas de la Facultad de Derecho de la Universidad de la República, y el fundador de la Escuela de Derecho de Rosario, Manuel de de Juano, quién fue el primero en establecer una cátedra de Derecho Financiero y Tributario en una universidad argentina, y que convirtió a Rosario en un centro de referencia internacional en la materia, al punto de ser la sede de la Asociación Interamericana de la Tributación. Además se explica el porqué del auge de los estudios de Derecho Tributario Internacional en el marco del Tratado de Montevideo de 1960,  la Asociación Latinoamericana de Libre Comercio (Alalc) y los postulados de la Carta de Punta del Este.","palabras_clave":"HISTORIA|DERECHO|UNIVERSIDAD|DESARROLLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87199,"idioma_id":5,"titulo":". El retorno al estado peligroso. La psiquiatría en el engranaje del poder punitivo moderno.","resumen":"En los últimos años el debate sobre el derecho penal fundado en la peligrosidad del autor ha resurgido en nuestro medio. Desde antaño, el poder punitivo intenta disminuir el riesgo de reincidencia criminal. En general, las recetas que se presentan son siempre similares;medidas preventivas basadas en mayor control social de aquellos sujetos consideradospeligrosos. Sin embargo, al momento de realizar tal empresa, el jurista no se encuentra solo sino que recurre a los expertos en las ciencias de la mente, quienes entran en su auxilio para así formar parte esencial del engranaje de la maquinaria del poder punitivo.1El retorno al estado peligrosoLa psiquiatría en el engranaje del poder punitivo moderno1Ezequiel N. MercurioIntroducciónEn los últimos años el debate sobre el derecho penal fundado en la peligrosidad del autor haresurgido en nuestro medio. Desde antaño, el poder punitivo intenta disminuir el riesgo dereincidencia criminal. En general, las recetas que se presentan son siempre similares;medidas preventivas basadas en mayor control social de aquellos sujetos consideradospeligrosos. Sin embargo, al momento de realizar tal empresa, el jurista no se encuentra solosino que recurre a los expertos en las ciencias de la mente, quienes entran en su auxilio,para así formar parte esencial del engranaje de la maquinaria del poder punitivo.Así, de forma similar al estado peligroso de origen positivista, el poder penal moderno lesolicita a los expertos que clasifiquen y determinen qué sujetos, considerados imputables ypunibles, presentan indicadores que permitan inferir que podrían volver a cometer el delitopor el cual fueron penados. En tal sentido, una vez realizada dicha delimitación de laanormalidad, que no implica enfermedad ni patología mental, el poder punitivo yaamalgamado con el poder psiquiátrico y psicológico, se encuentra en condiciones deimponer una medida preventiva, de neutralización, como consecuencia de las condicionesde peligrosidad que emanan del sujeto. Se trata así, de detectar indicadores psíquicos quepermitan explicar el delito, empero no en términos ausencia o disminución de culpabilidad.No se trata de enfermedades que implican algún grado de disminución de responsabilidadcriminal, todo lo contrario se trata de sujetos punibles pero anormales y peligrosos.el discurso ?científico? que muestra a sujetos anormales peligrosos para lasociedad se presenta como el terreno fértil para medidas restrictivas de la libertad basadas en un peligro futuro indeterminado con el objetivo de la defensa social. Dichos discursos sirven de plataforma ?científica? para habilitar medidas de neutralización, inocuización deldelincuente, sistemas dualistas que contemplen no sólo pena sino también una medida de seguridad indeterminada hasta que se desaparezcan la peligrosidad. Estos discursos llevados al extremo podrían plantear la desaparición de la fuente del peligro, ya que si el peligro emana en forma directa del sujeto anormal, es decir este es per se la causa del peligro para la sociedad y no puede resocializarse, modificarse o tratarse, la pena de muerteo encierro indeterminado, se presentarían como soluciones posibles, en un discurso extremo.comienzan a vislumbrarse rasgos significativos que remedan no sólo conceptos del positivismo del criminológico, tales como temilibilidad, peligrosidad y estado peligroso, sino también a legislaciones como la alemana y la estadounidense conmedidas y disposiciones posteriores a la pena.","palabras_clave":"Peligrosidad|Estado peligrosidad|Psiquiatria Forense|Criminologia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87202,"idioma_id":5,"titulo":"Imputabilidad por razones psiquiátricas y drogas de abuso. Nuevas perspectivas.","resumen":"Imputabilidad por razones psiquiátricas y drogas de abuso. Nuevas perspectivas.","palabras_clave":"Inimputabilidad penal|Drogas de abuso|Derecho penal |Psiquiatria Forense"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87206,"idioma_id":5,"titulo":"Sobre l´ilussion des sosie y la comprensión de la criminalidad del acto","resumen":"Comprensíón de la criminalidad del acto, la valoración y la vivencia","palabras_clave":"Inimputabilidad penal|Comprensión de la criminalidad|Psiquiatría forense|Sindrome de Capgras"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87240,"idioma_id":5,"titulo":"El tratamiento de la violencia de genero por los medios de comunicación","resumen":"El tratamiento de la violencia de genero por los medios de comunicación","palabras_clave":"TRATAMIENTO|VIOLENCIA|GÉNERO|MEDIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87277,"idioma_id":4,"titulo":"Major lake level fluctuations and climate changes for the past 16,000 years as reflected by diatoms and chironomids preserved in the sediment of Laguna Potrok Aike, southern Patagonia.","resumen":"Laguna Potrok Aike is a maar lakelocated in southernmost Argentinaand is one of the few permanent lakes preserving a continuous climatic recordfrom the semiarid Patagonian steppe. Furthermore, its location close toAntarctica provides a unique opportunity to compare paleoclimate fromcontinental South America with the polarrecords. The analysis of subfossil chironomids and diatoms throughout a 16-msedimentary record retrieved from this lake, combined with a well-constrainedchronology of the last ca 16 ka BP, provided a high resolutionpaleoenvironmental reconstruction of the limnology of the lake and regionalclimate conditions. The combination of both bioproxies showed humid conditions duringthe Lateglacial, followed by drier conditions during the Holocene, resulting inlarge variations in lake level. Despite not showing a clear evidence of a coldreversal similar to the Antarctic Cold Reversal and\/or the Younger Dryas, bothrecords suggest high water levels and oligotrophic conditions between 16.4 and11.5 cal. ka BP. The lake level drop that occurred at ca 8.7 ka BP is welldocumented by both bioproxies.","palabras_clave":"DIATOMS|CHIRONOMIDS|PALEOCLIMATIC RECONSTRUCTION|LATEGLACIAL|HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87397,"idioma_id":4,"titulo":"Rhipicephalus microplus ticks can complete their life cycle on the water buffalo (Bubalus bubalis)","resumen":"Rhipicephalus (Boophilus) microplus is considered one of the most important ectoparasites ofcattle worldwide. Due to the increase in the number of water buffaloes (Bubalus bubalis) in R. microplus-infested areas, this studywas designed to determine whether these ruminants are able to sustain the complete tick life cycle. To this aim, a seven-month old water buffalo of the Mediterranean breed and a Holstein bovine of the same age, both tick-naïve, were infested with R. microplus tick larvae, and the parasitic and non-parasitic tick stages were analyzed and compared. The studied parameters include the number of recovered engorged females, the time points at which the first and last engorged females fell to the ground; the pre-oviposition duration, the percentage of hatching and the reproductive efficiency index. No statistically significant differences were found between the buffalo and the bovine in all parameters measured. It was concluded that the water buffalo can act as a suitablereservoir for R. microplus ticks. These results should be taken into account when implementing tick control and eradication campaignsin water buffalo grazing lands.","palabras_clave":"Water buffalo|cattle tick|life cycle|epidemiology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87457,"idioma_id":5,"titulo":"Procesos judiciales y administrativos de adopción de niños. Confrontación de sentidos en la configuración de un 'medio familiar adecuado'","resumen":"En este trabajo se analizan las tensiones suscitadas entre los agentes del campo de instituciones destinadas a la protección de la infancia cuando el objetivo es proveer a los niños 'un medio familiar adecuado' y para ello se recurre a la adopción. A partir del análisis de casos relevados en nuestro trabajo de campo en el área metropolitana de Buenos Aires (Argentina), analizamos las formas que adquiere el tránsito de los niños hacia la adopción y las interacciones producidas entre los agentes institucionales y las familias de origen de los niños, ya que focalizando en las zonas de negociación y\/o confrontación que se abren en ellas es posible identificar diferentes tácticas desplegadas por los familiares de los niños a fin de disputar los alcances de la intervención y construir para sí un lugar moralmente aceptable. Desde esta perspectiva, entendemos, es posible complejizar el análisis de las dinámicas de internvención estatal sobre la infancia y sus familias.","palabras_clave":"Adopción|Familia|Organismos judiciales y administrativos |Tácticas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87521,"idioma_id":5,"titulo":"Conectando Comunidades, Construyendo Saberes","resumen":"Conectando Comunidades Construyendo SaberesClaudia Marcela Lomagno, Diego Hernán Zanetti, Laura Inés LonardiResumenDesde el año 2008 la cátedra de Educación y Comunicación Alimentario Nutricional (ECAN), de la Licenciatura en Nutrición de la Facultad de Bromatología \u2013 UNER, viene realizando una experiencia de articulación docencia-investigación-extensión, que constituye un aporte innovador&nbsp; al paradigma de formación e intervención en la universidad pública. La misma se viene desarrollando con continuidad en el Barrio Hipólito Irigoyen de la ciudad de Gualeguaychú, caracterizado por un conjunto de viviendas sociales, construidas con el fin de ubicar a&nbsp; familias que vivían en las zonas bajas costeras y que fueron desplazadas por la inundación de abril de 1959. Por su origen es conocido como el \u201CBarrio de los inundados\u201D. Trabajamos identificando necesidades y demandas comunitarias en torno a la \u201CSalud\u201D en general, y a lo \u201CAlimentario Nutricional\u201D en particular, tratando de dar respuestas en los aspectos que ameriten intervenciones educativas y comunicacionales. Construimos con los estudiantes instancias que permitan la sensibilización y la formación, articulando teoría y práctica, desarrollando intervenciones destinada a jóvenes y adultos sobre las problemáticas detectadas. Nos orientamos a indagar las representaciones y prácticas alimentarias de los participantes de instituciones y organizaciones comunitarias del barrio para concretar acciones socio-comunitarias, en conjunto, desde la perspectiva de la educación y de la comunicación popular en salud. A partir de 2011, con la sistematización de la información, comenzamos a realizar producciones multimediales educativo-comunicacionales en el marco de la incorporación de TIC´s en el aula, articulando el trabajo con escuelas secundarias de la ciudad incorporadas en el Programa Conectar Igualdad, en el marco de un proyecto de voluntariado universitario. Trabajamos en conjunto con instituciones educativas y organizaciones sociales: Club La Vencedora, Escuela Secundaria Nº 2 \u201CProf. Pablo Haedo\u201D, Parroquia Ntra. Sra. de Lourdes con sus instituciones dependientes (Centro y Comedor comunitario Casa del Niño y la Familia \u201CSan Martín de Porres\u201D), y Jardín de Infantes \u201CSanta Bernardita\u201D. En el abordaje se han tenido presente la participación real de los jóvenes y adultos involucrados, y la construcción colectiva de conocimiento, tanto de las situaciones problemáticas de la realidad, como de sus estrategias de acción para superarlas. En relación con la extensión universitaria esta experiencia de trabajo con las instituciones y organizaciones barriales propicia la construcción de ciudadanía desde una visión del derecho a la salud, la soberanía y seguridad alimentaria.","palabras_clave":"EDUCACIÓN POPULAR|COMUNICACIÓN POPULAR|EDUCACIÓN ALIMENTARIO NUTRICIONAL|PARTICIPACIÓN SOCIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87522,"idioma_id":5,"titulo":"Exigibilidad y justiciabilidad  desde la Epidemiología Territorial. Una construcción inicial con actores\/as comunales","resumen":"La Epidemiología Territorial Participativa articula conocimientos y técnicas provenientes de las ciencias sociales y la salud comunitaria que potencian prácticas implicadas y transformadoras. Igualdad y no discriminación se conjugan con los imperativos éticos de exigibilidad y justiciabilidad del derecho a  la salud. El objetivo del  trabajo es transmitir un primer momento de mapeo de actores y análisis de necesidades, demandas, problemas y prioridades de salud de las comunas 3 y 4, de la CABA, desde las narrativas y sentidos de actores sociales. Desde una perspectiva del Análisis Crítico del Discurso y la Investigación Acción Participativa,  identificamos situaciones sanitarias locales con efectores de Centros de de Salud y Acción Comunitaria, organizaciones de la sociedad civil, equipos técnicos de defensorías de niñas\/os y adolescentes, y docentes de escuelas medias. Triangulamos entrevistas, observación participante y dialéctica con  fuentes de datos de registros locales. Visualizamos nudos críticos en la percepción de derechos de ciudadanía de sectores de vecinos, y  la  incorporación de prácticas y  lógicas de inclusión de la diversidad de género, social y cultural.","palabras_clave":"Exigibilidad|Justiciabilidad|Epidemiología territorial|Comunas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87523,"idioma_id":5,"titulo":"Cartografía de la construcción de demandas por condiciones habitacionales en el barrio de La Boca. Una experiencia de Educación de Adultos desde la perspectiva de la Educación Popular y la Animación Sociocultural.","resumen":"Resumen     Esta experiencia se desarrolla en el barrio de la Boca. En esta intervención educativa con adultos confluyen las perspectivas teórica- metodológica de educación y comunicación popular y de animación sociocultural, enmarcadas en una concepción de educación permanente.    Su génesis implicó un análisis de la realidad barrial por parte de trabajadores de programas sociales del Estado, entendiendo que las acciones que cada uno se proponía desde su ámbito resultaban fragmentadas. Se evaluó la necesidad de articular estrategias y acciones concretas en el territorio, conformándose la Red Solidaria de La Boca. En el devenir de la tarea se definió la necesidad de generar la participación de organizaciones sociales, a fin de definir en conjunto las problemáticas vividas, avanzar en estrategias comunes, articulando demandas.    Se focalizó en la realización de un diagnóstico participativo acerca de qué pasa, qué hicimos y qué podríamos hacer con respecto a las condiciones habitacionales en el barrio de La Boca, confluyendo con familias afectadas por la problemática y organizaciones que la abordan desde distintos aspectos.    El trabajo realizado ha impactado en el crecimiento de los participantes en su capacidad de reconocimiento y análisis de problemáticas de su realidad cotidiana, estimulando el pensamiento reflexivo. La construcción colectiva de conocimientos fundamentó la elaboración de acciones transformadoras y participativas.    Se presentan los avances en la generación de conocimientos referidos a la construcción de demanda social por las condiciones habitacionales; visiones de los actores intervinientes; elaboración de un plan de intervención colectivo, innovador y creativo para la superación de las problemáticas identificadas.  ","palabras_clave":"educación permanente,|educación y comunicación popular|animación socio-cultural|construcción de demanda social"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87549,"idioma_id":5,"titulo":"La Neutralidad Argentina en la Guerra del Chaco","resumen":"x","palabras_clave":"x"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87552,"idioma_id":5,"titulo":"Reseña crítica sobre el libro de Carlos Dellepiane Cálcena, Bibliografía de la Política Exterior Argentina. 1810 2010","resumen":"x","palabras_clave":"x"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87591,"idioma_id":4,"titulo":"Effect of dietary calcium (Ca) on body composition and Ca metabolism during growth in genetically obese (&#946;) male rats.","resumen":"INTRODUCTION:         Obese &#946; rats may be a suitable model to evaluate the association between calcium intake (CaI) and obesity during growth.        OBJECTIVE:         The   present study comparatively evaluated Ca absorption and retention, and   changes in body composition in spontaneously genetically obese (&#946;) male   rats fed three different dietary Ca levels: high 0.9% (HCa); normal:   0.5% (NCa); low: 0.2% (LCa).        METHODS:         Pregnant rats were   fed isocaloric diets which varied in Ca content only. Male pups   continued feeding the same maternal diet until postnatal day 60. The   percentage of Apparent Ca absorption (CaA %), Ca balance (CaB), body   composition, glucose, triglycerides (TGL), and insulin levels were   evaluated.        RESULTS:         Food consumption and body weight (BW)   were higher in Group LCa than in Groups NCa and HCa (p&nbsp;&lt;&nbsp;0.01); no   differences were observed between the latter two groups. Group LCa   presented the highest body fat, liver weight, perigonadal and   retroperitoneal fat (p&nbsp;&lt;&nbsp;0.05); conversely, body ashes and total   skeleton bone mineral content were significantly lower compared with   animals in both the NCa (p&nbsp;&lt;&nbsp;0.01) and HCa groups (p&nbsp;&lt;&nbsp;0.01). CaB   (mg\/day) reached a plateau at the highest CaI (mg\/day) value (r&nbsp;=&nbsp;0.985,   p&nbsp;&lt;&nbsp;0.001). CaA%, serum glucose, insulin, and TGL levels rose as CaI   decreased (p&nbsp;&lt;&nbsp;0.01).        CONCLUSIONS:         Although further   studies are required, low Ca consumption in this strain of rats could   modulate BW inducing changes in several lipid metabolism parameters,   which in turn lead to an increase in body fat.","palabras_clave":"DIETARY|CA.LCIUM|BODY COMPOSITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87594,"idioma_id":5,"titulo":"Resistencia, moralidad y clase. Elementos para pensar lo popular desde E. P. Thompson","resumen":"En el presente trabajo analizaremos algunas de las herramientas teórico-metodológicas aportadas por los desarrollos de E. P. Thompson para un programa de investigación sobre la cultura popular en términos de acciones cargadas de sentido, cultura y moralidad, ancladas al mismo tiempo en procesos materiales y culturales como intrínsecamente complejos y constituidos en la conflictividad.Una primera parte del trabajo se orientará a reconstruir las críticas y disputas entre algunas expresiones del denominado ?materialismo cultural? y los representantes del estructuralismo marxista althusseriano y sus exponentes en Inglaterra.En un segundo momento, plantearemos en líneas generales, el uso de la categoría de Clase Social que Thompson hace en sus textos históricos, fundamentalmente en lo referido a la introducción de la noción de experienciacomo herramienta conceptual para pensar las prácticas y las luchas de clase en el capitalismo en ciernes.Por último, terminaremos el escrito con algunas reflexiones en torno a los aportes de este autor para abordar la cultura popular en tanto conflicto con el simbolismo dominante, con el objeto de construir una mirada que se centre en la relación de tensión y de ambivalencia en los procesos de lucha y dominación de clase en el capitalismo.","palabras_clave":"cultura popular|clase|experiencia|procesos culturales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87596,"idioma_id":5,"titulo":"EDUCACIÓN SUPERIOR E INTERCULTURALIDAD EN MISIONES-ARGENTINA","resumen":"El presente artículo es parte de mi tesis de grado, en la cual se intenta describir y analizar las posibilidades y condiciones de acceso al sistema educativo superior por parte de estudiantes guaraníes (Mbya y Avá chiripa), captando las principales dificultades que deben enfrentar en su intento por ingresar y permanecer en la institución educativa de la sociedad dominante. Para tal fin se toma como población objeto a los estudiantes guaraníes que ingresaron a la Facultad de Humanidades y Ciencias Sociales (FHyCS) de la Universidad Nacional de Misiones (UNaM) desde el período 2008 a 2012.","palabras_clave":"Guaraníes|Educación|Universidad|Capital Cultural"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87613,"idioma_id":5,"titulo":"Reseña: Síntoma y semblante. La actualidad de la clínica analítica.","resumen":"Reseña del libro del Instituto Oscar Masotta de Río Gallegos que compila una serie de intervenciones y que lleva como título Síntoma y semblante.","palabras_clave":"Síntoma |Semblante|Psicoanálisis lacanianos|Geopolíticas del conocimiento"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87670,"idioma_id":5,"titulo":"Ensayo reseña Tiempos de homenajes\/tiempos descoloniales: Frantz Fanon. Alejandro De Oto (comp.)","resumen":"Tiempos de homenajes\/tiempos descoloniales: Frantz Fanon, de la serie de Ediciones del Signo, El desprendimiento del pensamiento descolonial, propone retomar los caminos del pensamiento crítico que Fanon dejó abiertos y a los cuales el prólogo de Walter Mignolo y los ensayos de Alejandro de Oto, María Eugenia Borsani, María Marta Quintana, Zulma Palermo e Inés Fernández Mouján rinden homenaje, transitándolos y mostrando las frecuentes intersecciones de los mismos con algunos lugares claves del pensamiento crítico latinoamericano. Este ensayo reseña transita algunas de las preguntas planteadas por el conjunto de ensayos compilados por De Oto, como por qué leer a Fanon en la América Latina actual? Cuáles son los cruces del pensamiento fanoniano con algunos de los principales referentes del latinoamericanismo? ¿qué es aquello en los escritos de Fanon que permite que sus textos, teorías, discursos sean hoy re-encendidos , vueltos a desplegar?para utilizar un término de Michel Foucault que realza el valor estratégico del discurso fanoniano?","palabras_clave":"FRANTZ FANON|LATINOAMERICANISMO|GIRO DESCOLONIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87736,"idioma_id":4,"titulo":"Habitat use of the wild boar, Sus scrofa Linnaeus 1758, in Los Alerces National Park, Argentina","resumen":"The aim of this work was to study the patterns of habitat use of the wild boar in Los Alerces National Park,Argentina. We surveyed 262 transects, totaling 26.2 km, searching for fresh signs of the species. The wild boarused low elevations more intensively (600 to 700 m asl) than higher elevations, and forests of Nothofagus dombeyiand N. antarctica with understory dominated by Chusquea culeou than other vegetation types. The occurrence ofsigns among elevation strips and vegetation types was different between summer and autumn. Our results mightbe helpful for park managers and park rangers in developing wild boar control plans.","palabras_clave":"Introduced species|Vegetation use|Elevation use|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87765,"idioma_id":4,"titulo":"Lifshitz scalar fields: One loop renormalization in curved backgrounds","resumen":"We consider an interacting Lifshitz field with z=3 in a curved spacetime. We analyze the renormalizability of the theory for interactions of the form &#955;&#981;n, with arbitrary even n. We compute the running of the coupling constants both in the ultraviolet and infrared regimes. We show that the Lorentz-violating terms generate couplings to the spacetime metric that are not invariant under general coordinate transformations. These couplings are not suppressed by the scale of Lorentz violation and therefore survive at low energies. We point out that in these theories, unless the effective mass of the field is many orders of magnitude below the scale of Lorentz violation, the coupling to the four-dimensional Ricci scalar &#958;(4)R&#981;2 does not receive large quantum corrections &#958;&#8811;1. We argue that quantum corrections involving spatial derivatives of the lapse function (which appear naturally in the so-called healthy extension of the Ho&#345;ava-Lifshitz theory of gravity) are not generated unless they are already present in the bare Lagrangian.","palabras_clave":"quantum fields|curved spacetime|modified gravity|renormalization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87766,"idioma_id":4,"titulo":"The presence of the seahorse Hippocampus patagonicus in the Argentine Sea based on the Cytochrome b sequence of mitochondrial DNA","resumen":"This study aimed at sequencing the mitochondrial cytochrome b gene (cyt b) of seahorses morphologically identified as Hippocampus patagonicus from the two known localities where the species occur in the Argentine Sea (San Antonio Oeste and Mar del Plata). Based on the lack of substitutions within cyt b found between the individuals of both localities, the geographical range of H. patagonicus was extended up to the Northern limit of the Argentine Sea. A phylogenetic analysis comparing the cyt b sequences of Hippocampus species revealed that H. patagonicus together with H. hippocampus and H. erectus belong to a monophyletic group of species. The comparison of the cyt b sequence of Hippocampus cf. erectus from Southern Brazil with that one of H. patagonicus resulted in scarce differences. This could suggest the presence of H. patagonicus in southern Brazil, although, further investigation is needed to resolve the taxonomic status of H. erectus in the South Western Atlantic","palabras_clave":"SYNGNATHIDAE|CYT-B|HIPPOCAMPUS ERECTUS|SOUTH WESTERN ATLANTIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87767,"idioma_id":4,"titulo":"The chemistry of the sulfur-gold interface: in search of a unified model","resumen":"        Over the last three decades, self-assembled  molecular films on solid surfaces have attracted widespread interest as an intellectual  and technological challenge to chemists, physicists, materials scientists, and  biologists. A variety of technological applications of nanotechnology rely on  the possibility of controlling topological, chemical, and functional features  at the molecular level. Self-assembled monolayers (SAMs) composed of  chemisorbed species represent fundamental building blocks for creating complex  structures by a bottom-up approach. These materials take advantage of the  flexibility of organic and supramolecular chemistry to generate synthetic  surfaces with well-defined chemical and physical properties. These films  already serve as structural or functional parts of sensors, biosensors,  drug-delivery systems, molecular electronic devices, protecting capping for nanostructures,  and coatings for corrosion protection and tribological applications. Thiol SAMs  on gold are the most popular molecular films because the resulting oxide-free,  clean, flat surfaces can be easily modified both in the gas phase and in liquid  media under ambient conditions. In particular, researchers have extensively  studied SAMs on Au(111) because they serve as model systems to understand the  basic aspects of the self-assembly of organic molecules on well defined metal  surfaces. Also, great interest has arisen in the surface structure of  thiol-capped gold nanoparticles (AuNPs) because of simple synthesis methods  that produce highly monodisperse particles with controllable size and a high  surface\/volume ratio. These features make AuNPs very attractive for  technological applications in fields ranging from medicine to heterogeneous  catalysis. In many applications, the structure and chemistry of the sulfurgold  interface become crucial since they control the system properties. Therefore,  many researchers have focused on understanding of the nature of this interface  on both planar and nanoparticle thiol-covered surfaces. However, despite the  considerable theoretical and experimental efforts made using various  sophisticated techniques, the structure and chemical composition of the sulfurgold  interface at the atomic level remains elusive. In particular, the search for a  unified model of the chemistry of the SAu interface illustrates the difficulty  of determining the surface chemistry at the nanoscale. This Account provides a  state-of-the-art analysis of this problem and raises some questions that  deserve further investigation.","palabras_clave":"Self-assembled monolayers|Gold|Sulfur|Nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87768,"idioma_id":4,"titulo":"Vascular accesses for haemodialysis in the upper arm cause greater reduction in the carotid-brachial stiffness than those in the forearm: study of gender differences","resumen":"Purpose. To evaluate in chronicallyhaemodialysed patients (CHPs), if: (1) the vascular access (VA) position (upperarmor forearm) is associated with differential changes in upper limb arterialstiffness; (2) differences in arterial stiffness exist between gendersassociated with the VA; (3) the vascular substitute (VS) of choice, inbiomechanical terms, depends on the previous VA locationand CHP gender. Methods.38 CHPs (18 males; VA in upper arm: 18) were studied. Left and rightcarotid-brachial pulse wave velocity (PWVc-b) was measured. In in vitrostudies, PWV was obtained in ePTFE prostheses and in several arterial andvenous homografts obtained from donors. The biomechanical mismatch (BM) betweenCHP native vessel (NV) and VS was calculated. Results\/Conclusions. PWVc-b inupper limbs with VA was lower than in the intact contralateral limbs (P &lt;0.05), and differences were higher (P &lt; 0.05) when the VA was performed inthe upper arm. Differences between PWVc-b in upper limbs with VA (in the upperarm) with respect to intact upper limbs were higher (P &lt; 0.05) in males. Independentlyof the region in which the VA was performed, the homograft that ensured theminimal BM was the brachial artery. The BMwas highly dependent on gender andthe location in the upper limb in which the VA was performed.","palabras_clave":"Aretrial Stiffnes|ePTFE|PWV"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87769,"idioma_id":4,"titulo":"Fluvial styles, palaeohydrology and modern analogues of an exhumed, Cretaceous fluvial system: Cerro Barcino Formation, Cañadón Asfalto Basin, Argentina","resumen":"Superb surface exposures of a fluvial palaeochannel-belt 2e5 km wide and 13 km long occur in Cretaceous sedimentary rocks of the Cerro Barcino Formation (Las Plumas Member), Chubut Group, Cañadón Asfalto Basin, Argentina. The exceptional plan-view exposures of fluvial sandbodies allowed identification of a large number of WNWeESE sinuous ridges that represent high-sinuosity, braided and lowsinuosity fluvial palaeochannels, crevasse and chute palaeochannels, and crevasse-splay deposits.Predominance of low-sinuosity palaeochannels and low values of the width\/thickness ratio of most them suggest high stability of their margins, probably controlled by the cohesiveness of tuffaceous floodplain deposits. Morphological and sedimentological observations provide evidence of abrupt lithofacies changes in palaeochannel fills, fine-grained intercalations in multi-storey palaeochannels and occurrence of different fluvial styles, implying temporal\/spatial variations in palaeodischarge and\/or slope conditions. Comparison of the near-identical plan view morphology of the Cretaceous palaeochannel belt with the nearby Chubut River, plus the comparison of palaeohydrological data of the exhumed palaeochannels with hydrological data from this modern analogue, gives evidence of a very similar fluvial behaviour. This provides an integrative tool to be employed in the study of other ancient fluvial successions, including the reconstruction of palaeofluvial hydrological parameters in planetary geology.","palabras_clave":"EXHUMED PALAEOCHANNELS|PALAEOHYDROLOGY|MODERN ANALOGUE|CERRO BARCINO FORMATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87770,"idioma_id":5,"titulo":"Elementos para una Ingeniería de Explotación de Información","resumen":"Los Proyectos de Explotación de Información difieren sustancialmente de los pertenecientes al Software tradicional. Las fases clásicas de desarrollo le son ajenas, al igual que las herramientas involucradas en los procesos de Ingeniería en Software. Un nuevo cuerpo de conocimientos atento a las necesidades de su aplicación industrial, deviene, pues, imprescindible para el avance del nuevo campo disciplinar. En este artículo proponemos: un modelo de negocio, un proceso de educción de requisitos, un método de estimación, una metodología de selección de herramientas, un proceso de transformación de datos y una serie de procesos basados en técnicas de minería de datos.","palabras_clave":"INGENIERÍA EN SOFTWARE|EXPLOTACIÓN DE INFORMACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87771,"idioma_id":4,"titulo":"About the cure kinetics in Natural Rubber\/Styrene Butadiene Rubber blends at 433 K","resumen":"Vulcanized blends of elastomers are employed in several goods mainly to improve physical properties and reduce costs. One of the most used blends of this kind is that composed by natural rubber (NR) and styrene butadiene rubber (SBR). The cure kinetic of these blends depends mainly on the compound formulation and the cure temperature and time. The preparation method of the blends can influence the mechanical properties of the vulcanized compounds.In this work the cure kinetic at 433 K of NR\/SBR blends vulcanized with the system sulfur\/TBBS (N-t-butyl-2-benzothiazole sulfenamide) is analyzed in samples prepared by mechanical mixing and solution blending.The two methods produce elastomer domains of NR and SBR, which present different microstructure due to the cure level attained during vulcanization.The cure kinetics is studied by means of rheometer tests and the model proposed by Kamal and Sourour. The analysis of the cure rate is presented and is related to the structure obtained during the vulcanization process.","palabras_clave":"Caucho natural|SBR|Cinetica de cura"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87772,"idioma_id":4,"titulo":"Neofusicoccum parvum, blueberry pathogen in Argentina","resumen":"Buenos Aires province constitutes one of the main blueberry (Vaccinium corymbosum) production areas in Argentina. During disease surveys in 2008\/2009, a new pathology was observed for this region. In Chascomús, twig and stem blight were observed on three-year old plants of Brighitta and Duke. Disease incidence reached 40%. Plants could occasionally die. Diseased samples were surface disinfected with 0.2% NaOCl and cultivated on 2% Potato Dextrose Agar (PDA) at 20 ºC. After 21 days under a 12-hour photoperiod, the initially white fungal colonies showed abundant gray to dark gray aerial mycelium, with no sporulation. Pycnidia only developed when the fungus was cultivated on sterilized pine needles placed on 2% water agar (WA), at 22 ºC. Conidia were fusiform to elliptic, with a subobtuse apex and truncate base, hyaline, non-septate. Afterwards conidia frequently became olivaceus and developed 1-2 septa with a darker middle cell. Mean conidial dimensions were 14.68 x 5.85 &#956;m. The teleomorph was not observed. To proof pathogenicity, one cm2 PDA plugs with fungal were placed on the stem base of previously injured one-year old blueberry plants of cv. Duke. Initial characteristic symptoms were observed after a week. At day 15th, some twigs showed blight up to 6 to 10 cm. After a month, blight reached 20 to 30 cm long. Uninoculated plants remained symptomless. The pathogen was identified as Neofusicoccum parvum. To our knowledge, this paper constitutes the first reference of N. parvum in Argentina as pathogen on blueberry plants.","palabras_clave":"PLANT FUNGI|HIGHBUSH BLUEBERRY|VACCINIUM CORYMBOSUM|PLANT PATHOGENS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87773,"idioma_id":4,"titulo":"First report of Amblyomma boeroi Nava, Mangold, Mastropaolo, Venzal, Oscherov and Guglielmone (Acari: Ixodidae) from the Chacoan peccary, Catagonus wagneri (Artiodactyla: Tayassuidae), in Paraguay","resumen":"All stages of the hard tick Amblyomma boeroi Nava, Mangold, Mastropaolo, Venzal, Oscherov and Guglielmone were found for the first time on two carcasses of the Chacoan peccary, Catagonus wagneri, in Paraguay, one from a site located 100 km west of Mariscal Estigarribia (S 21°29\u2019, W 61°22\u2019), and the other from Destacamento Teniente Martinez (S 20°55\u2019, W 59°50\u2019), Boquerón Department.","palabras_clave":"Amblyomma boeroi|Catagonus wagneri|16S rDNA|Paraguay"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87774,"idioma_id":4,"titulo":"Ornithodoros peruvianus Kohls, Clifford & Jones (Ixodoidea: Argasidae) in Chile: a tentative diagnosis","resumen":"Three argasid tick larvae were collected on April 2, 2010, from a common vampire bat, Desmodus rotundus, captured in the Parque Nacional Pan de Azúcar (26°09&#8242; S, 70°41&#8242; W), Region of Atacama, Chile. The larvae were diagnosed              as Ornithodoros, and further comparative analysis showed them to be Ornithodoros peruvianus Kohls, Clifford &amp; Jones or a species close to it. Phylogenetic analysis based on 16S mitochondrial rRNA gene sequences of              Ornithodoros species plus four Argas species was carried out to clarify the taxonomic position of the larvae. This is the first finding of ticks parasitizing              D. rotundus in Chile.","palabras_clave":"Ornithodoros peruvianus |Desmodus rotundus|16S sequence|Chile"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87775,"idioma_id":4,"titulo":"Reinstatement of Rhipicephalus (Boophilus) australis (Acari: Ixodidae) with redescription of the adult and larval stages","resumen":"Rhipicephalus australis Fuller, the Australian cattle tick, is reinstated and the adults and larvae redescribed from material collected in Australia. This long ignored boophilid was previouslyknown as R. microplus Canestrini for specimens reported in Australia and New Caledonia. The adults of R. australis are easily recognized by a combination of characters, such as the ventro-medial spurs in the palpal segments of the male, and the abundant, plumose, pale white setae on the dorsum of thefemale. Other details, such as coxal and adanal shields are more variable among different populations and may lead to incorrect determinations. Larvae of R. australis are clearly smaller than those of R. microplus. The use of principal components analysis on body measurements leads to a clear separation of larvae of both taxa. A phylogenetic analysis based on 12S- and 16S-rDNA gene sequences supports the conspeciÞcity of the neotype material on which the reinstatement of the species is proposed, and of the specimens used for previous interspeciÞc crosses. R. australis is now known to be present in Australia, New Caledonia, the island of Borneo, Philippines, Sumatra, Java, New Guinea, Cambodia, and Tahiti. Both R. microplus and R. australis coexist in some countries in southeastern Asia. Given the extreme importance of these ticks for the cattle industry, Þeld data on their distribution in the region are required to know the actual range of these species and to understand the evolution of the group.","palabras_clave":"Rhipicephalus (Boophilus) australis|Australian cattle tick|reinstatement|redescription"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87776,"idioma_id":5,"titulo":"A systemic vaccine based on Escherichia coli O157: H7 bacterial ghosts (BGs) reduces the excretion of E. coli O157: H7 in calves.","resumen":"Cattle are the main reservoir of enterohemorrhagic Escherichia coli O157:H7, a bacteriumthat, in humans, causes hemorrhagic colitis and hemolytic uremic syndrome (HUS), a lifethreateningdisease, especially in children and older people. Therefore, the developmentof vaccines preventing colonization of cattle by E. coli O157:H7 could be a main tool for anHUS control program. In the present study, we evaluated bacterial ghosts (BGs) of E. coliO157:H7 as an experimental vaccine against this pathogen. BGs are empty envelopes ofGram-negative bacteria, which retain the morphological surface make-up of their livingcounterparts and are produced by controlled expression of the cloned protein E, whichcauses loss of all the cytoplasm content. In this work, E. coli O157:H7 BGs were used forsubcutaneous immunization of calves. The vaccinated animals elicited significant levels ofBG-specific IgG but not IgA antibodies in serum. Low levels of IgA and IgG antibodies againstBGs were detected in saliva from vaccinated animals. Following oral challenge with E. coliO157:H7, a significant reduction in both the duration and total bacterial shedding wasobserved in vaccinated calves compared to the nonimmunized group. We demonstratedthat systemic vaccination with E. coli O157 BGs provides protection in a bovine experimentalmodel. Further research is needed to reach a higher mucosal immune response leading toan optimal vaccine.","palabras_clave":"STEC|Eschrichia coli|vaccine|bacterial ghsosts"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87777,"idioma_id":4,"titulo":"Two-Photon Photoluminescence from Hierarchical ZnO Nanostructures","resumen":"Hierarchical ZnO nanostructures (such as nanowires, nanocombs and nanohedgehogs) were grown by means of a vapor-phase transport technique in a tubular furnace. Silicon based substrates were used, over which Au nanoclusters were deposited as growth catalyzers. We study the two-photon absorption induced photoluminescence (TPPL) from the various ZnO nanoobjects grown using a micrometer sized polarised laser beam as the  excitation source. The UV region of the TPPL spectra contains various peaks whose different patterns depend on the type of nanostructure and its orientation with respect to the incident polarization. We identify the peaks in the TPPL spectra, which are found to be dominated by free exciton emission and their phonon replicas. For the nanocomb, however, Fabry-Perot modes originating from optical multiple reflections within the comb\u2019s teeth are demonstrated.","palabras_clave":"ZNO|NANOESTRUCTURAS|FOTOLUMINISCENCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87778,"idioma_id":5,"titulo":"Configuración y demandas de los movimientos sociales hacia la Asamblea Constituyente en Bolivia y Ecuador","resumen":"El presente trabajo propone un análisis comparativo entre la Confederación de Pueblos Indígenas del Oriente Boliviano (CIDOB) y la Confederación de Nacionalidades Indígenas de la Amazonía Ecuatoriana (CONFENIAE). Para ello tendremos en cuenta las características específicas de los territorios en los que se desenvuelven estas  organizaciones, su emergencia conjunta a partir de la década de los ochenta y las transformaciones políticoinstitucionales que tienen lugar en ambos países. Se analizan las acciones colectivas en torno a la disputa por el territorio y las demandas que de ellas emanan en materia de reordenamiento territorial. El recorte temporal contempla el período 1990-2007, donde se observa la confluencia de acciones colectivas que visibilizan a nivel nacional la demanda por el territorio. Este proceso alcanza su traducción institucional en los textos constitucionales, a partir de los cuales se abre un escenario político que habilita nuevas luchas por su interpretación e implementación.","palabras_clave":"Proceso Constituyente|Territorio |Organizaciones Indígenas|Ecuador y Bolivia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87779,"idioma_id":4,"titulo":"Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor","resumen":"The á9 and á10 cholinergic nicotinic receptor subunits assemble to form the receptor that mediates efferent inhibition of hair cell function within the auditory sensory organ, a mechanism thought to modulate the dynamic range of hearing. Contrary to all nicotinic receptors which serve excitatory neurotransmission, the activation of á9á10 produces hyperpolarization of hair cells. An evolutionary analysis has shown that the á10 subunit shows signatures of positive selection only along the mammalian lineage, strongly suggesting the acquisition of a novel function. To establish if mammalian á9á10 receptors have acquired novel functional properties, as a consequence of this evolutionary pressure, we have compared the properties of rat and chicken recombinant and native á9á10 receptors. The main finding of the present work is that, in contrast to the high (pCa2+\/pMonovalents ~ 10) Ca2+ permeability reported for rat á9á10 receptors, recombinant and native chicken á9á10 receptors have a much lower permeability (~ 2) to this cation, comparable to that of neuronal á4â2 receptors. Moreover, we show that, contrary to á10, á7 as well as á4 and â2 nicotinic subunits are under purifying selection in vertebrates, consistent with the conserved Ca2+ permeability reported across species. These results have important consequences for the activation of signaling cascades that lead to hyperpolarization of hair cells following á9á10 gating at the cholinergic-hair cell synapse. In addition, they suggest that high Ca2+ permeability of the á9á10 cholinergic nicotinic receptor might have evolved together with other features which have rendered a mammalian ear with an expanded high frequency sensitivity.","palabras_clave":"inner ear|nicotinic receptor|evolution|hair cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87780,"idioma_id":4,"titulo":"The efferent medial olivocochlear hair cell synapse","resumen":"Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of a9 and a10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.","palabras_clave":"cochlea|nicotinic receptors|hearing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87781,"idioma_id":4,"titulo":"Complete Reaction Mechanism of Indoleamine 2,3-Dioxygenase as Revealed by QM\/MM Simulations","resumen":"ABSTRACT: Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase&nbsp;(TDO) are two heme proteins that catalyze the oxidation reaction of tryptophan (Trp) to N-formylkynurenine (NFK). Human IDO (hIDO) has recently been recognized as a potent anticancer drug target, a fact that triggered intense research on the reaction and inhibitionmechanisms of hIDO.&nbsp; Our recent studies revealed that the dioxygenasereaction catalyzed by hIDO and TDO is initiated by addition of the ferric iron-bound superoxide to the C2dC3 bond of Trp to form a ferryl and Trp epoxide intermediate, via a 2-indolenylperoxo radical transition state. The data demonstrate that the two atoms ofdioxygen are inserted into the substrate in a stepwise fashion, challenging the paradigm of heme-based dioxygenase chemistry. In the current study, we used QM\/MM methods to decipher the mechanism by which the second ferryl oxygen is inserted into theTrp epoxide to formthe NFK product in hIDO. Our results show that the most energetically favored pathway involves proton transfer from Trp NH3+ to the epoxide oxygen, triggering epoxide ring opening and a concerted nucleophilic attack of the ferryl oxygen to the C2 of Trp that leads to a metastable reaction intermediate. This intermediate subsequently converts toNFK, followingC2&nbsp; C3 bond cleavageand the associated back proton transfer from the oxygen to the amino group of Trp. A comparative study with Xantomonas campestris TDO(xcTDO) indicates that the reaction follows a similar pathway, although subtle differences distinguishing the two enzyme reactionsare evident. The results underscore the importance of the NH3+ group of Trp in the two-step ferryl-based mechanism of hIDO and&nbsp; xcTDO, by acting as an acid catalyst to facilitate the epoxide ring-opening reaction and ferryl oxygen addition to the indole ring.","palabras_clave":"heme protein|indoleamine dioxygenase|computer simulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87782,"idioma_id":4,"titulo":"On fusion categories with few irreducible degrees","resumen":"We prove some results on the structure of certain classes of integral fusion  categories and semisimple Hopf algebras under restrictions on the set of its  irreducible degrees.","palabras_clave":"fusion category|semisimple Hopf algebra|irreducible degree"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87783,"idioma_id":5,"titulo":"Inteligencia cultural, valores y motivación para el aprendizaje en estudiantes militares argentinos","resumen":"El estudio tuvo como objetivo analizar si existen relaciones entre los niveles de inteligencia cultural desplegados por estudiantes militares argentinos, su motivación para el aprendizaje académico y los valores humanos vinculados al área laboral. Participaron 400 cadetes aspirantes a oficiales del Ejército Argentino (377 hombres y 23 mujeres) provenientes de diversas provincias argentinas. Se realizaron análisis de correlación bivariados a través del coeficiente r de Pearson, cuyos resultados indican que los estudiantes presentan valores vinculados al cuidado de las tradiciones nacionales, al tiempo que el valor \u201Cestimulación\u201D se asocia con la resolución creativa y original de experiencias nuevas o situaciones inciertas, equilibrando cierta auto-restricción que limitaría la apertura hacia la diversidad cultural.","palabras_clave":"INTELIGENCIA CULTURAL|MOTIVACION PARA EL APRENDIZAJE|VALORES HUMANOS|ESTUDIANTES MILITARES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87784,"idioma_id":4,"titulo":"Molecular basis of intramolecular electron transfer in proteins during radical mediated oxidations: Computer simulation studies in model tyrosine-cysteine peptides in solution","resumen":"Experimental studies in hemeproteins and model Tyr\/Cys-containing peptides exposed to oxidizing and nitrating species suggest that intramolecular electron transfer (IET) between tyrosyl radicals (Tyr-O) and Cys residues controls oxidative modification yields. The molecular basis of this IET process is not sufficiently understood with structural atomic detail. Herein, we analyzed using molecular dynamics and quantum mechanics-based computational calculations, mechanistic possibilities for the radical transfer reaction in Tyr\/Cys-containing peptides in solution and correlated them with existing experimental data.Our results support that Tyr-O to Cys radical transfer is mediated by an acid\/base equilibrium that involves deprotonation of Cys to form the thiolate, followed by a likely rate-limiting transfer process to yield cysteinyl radical and a Tyr phenolate; proton uptake by Tyr completes the reaction. Both, the pKa values of the Tyr phenol and Cys thiol groups and the energetic and kinetics of the reversible IET are revealed as key physico-chemical factors. The proposed mechanism constitutes a case of sequential,acid\/base equilibrium-dependent and solvent-mediated, proton-coupled electron transfer and explains the dependency of oxidative yields in Tyr\/Cys peptides as a function of the number of alanine spacers.These findings contribute to explain oxidative modifications in proteins that contain sequence and\/or spatially close Tyr?Cys residues.","palabras_clave":"Electron transfer|Peptides|Electron pathways|PCET"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87785,"idioma_id":5,"titulo":"Muestreo mixto online: Una aplicación en poblaciones ocultas","resumen":"- Objeto: El objetivo de este artículo es explorar las posibilidades que ofrecen las nuevas tecnologías de información y la aparición de las redes sociales virtuales, para el reclutamiento de unidades muestrales en poblaciones ocultas y como soporte del uso de métodos mixtos.  - Diseño\/metodología\/enfoque: El objetivo era identificar a los empresarios argentinos que iniciaron negocios en España. Esta unidad de observación, presenta características que la definen como población oculta: 1) elevada dispersión geográfica que dificulta su localización; 2) subestimación en el número de argentinos residentes en las estadísticas oficiales; 3) argentinos residentes en situación ilegal; y, 4) en muchos casos los factores que motivaron la emigración son negativos, por lo que genera reticencia a contestar.  En este contexto, se desarrolló (1) el muestreo virtual online y (2) el muestreo por bola de nieve tradicional. En el muestreo virtual online se utilizó la red social Facebook, mediante la cual se identificaron 52 grupos virtuales que nuclean a argentinos que viven en España. Posteriormente, se envío a cada miembro un mensaje personal explicando el propósito del estudio e invitándolos a participar en el mismo.  - Aportaciones y resultados: A través de la realización del estudio, se comprueba que mediante el uso de redes sociales es posible acceder a unidades de observación que no se hubieran detectado por vías institucionales (registros administrativos, censos, etc.). Este resultado demuestra que este tipo de herramientas, contribuyen a incrementar el alcance geográfico y el tamaño de la muestra, favorecen al diseño de la muestra cualitativa y la triangulación de resultados, aumentando la validez de los estudios de poblaciones ocultas.  - Originalidad \/ Valor añadido: El artículo presenta una experiencia de aplicación de muestreo virtual y métodos mixtos en el estudio de poblaciones ocultas, a partir del análisis del empresariado inmigrante argentino y utilizando como fuentes de información los grupos virtuales.","palabras_clave":"muestreo virtual|poblaciones ocultas|métodos mixtos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87786,"idioma_id":4,"titulo":"Bioinspired sparse spectro-temporal representation of speech for robust classification","resumen":"In this work, a first approach to a robust phoneme recognition task by means of a biologically-inspired feature extraction method is presented. The proposed technique provides an approximation to the speech signal representation at the auditory cortical level. It is based on an optimal dictionary of atoms, estimated from auditory spectrograms, and the Matching Pursuit algorithm to approximate the cortical activations. This provides a sparse coding with intrinsic noise robustness, which can be therefore exploited when using the system in adverse environments. The recognition task consisted in the classification of a set of 5 easily confused English phonemes, in both clean and noisy conditions. Multilayer perceptrons were trained as classifiers and the performance was compared to other classic and robust parameterizations: the auditory spectrogram, a probabilistic optimum filtering on mel frequency cepstral coefficients and the perceptual linear prediction coefficients. Results showed a significant improvement in the recognition rate of clean and noisy phonemes by the cortical representation over these other parameterizations.","palabras_clave":"Robust phoneme recognition|Auditory cortical representation|Sparse coding"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87787,"idioma_id":4,"titulo":"Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosis","resumen":"Arq Neuropsiquiatr. 2012 Jan;70(1):40-4.Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosis.Rodríguez GE, González DM, Monachelli GM, Costa JJ, Nicola AF, Sica RE.SourceNeurology Department, Hospital Ramos Mejía, Buenos Aires, Argentina. gerodrig@intramed.netAbstractOBJECTIVES: Mitochondrial dysfunction has been reported in the central nervous system, hepatocytes and peripheral blood lymphocytes from patients with sporadic amyotrophic lateral sclerosis (SALS). However, the status of skin mitochondria has not been reported, in spite of the fact that SALS patients present skin abnormalities. The objective of the present study was to compare mitochondrial ultrastructural parameters in keratinocytes from patients with SALS and healthy controls.METHODS: Our study was based on the analysis of 112 skin mitochondria from 5 SALS patients and 99 organelles from 4 control subjects by electron microscopy.RESULTS: Computerized image analysis showed that mitochondrial major axis length, area and perimeter of the organelle were significantly smaller in SALS respect of healthy control subjects. Morphologically, SALS mitochondria presented cristolysis and breakage of the outer membrane.CONCLUSIONS: Mitochondrial dysfunction in the skin may possibly reflect changes occurring in mitochondria of the central nervous system. The analysis of mitochondrial morphology in this tissue may be of value to follow disease progression and, eventually, the effectiveness of current therapies for SALS.","palabras_clave":"Amyotrophic lateral sclerosis|skeletal muscle|oxidative stress|mitochondria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87788,"idioma_id":4,"titulo":"Quasi-optimal convergence rate of an AFEM for quasi-linear problems of monotone type","resumen":"We prove the quasi-optimal convergence of a standard adaptive finite element method (AFEM) for a class of nonlinear elliptic second-order equations of monotone type. The adaptive algorithm is based on residual-type a posteriori error estimators and Dörfler´s strategy is assumed for marking. We first prove a contraction property for a suitable definition of total error, analogous to the one used by Diening and Kreuzer and equivalent to the total error defined by Cascón, Kreuzer, Nochetto and Siebert. This contraction implies linear convergence of the discrete solutions to the exact solution in the usual $H^1$ Sobolev norm. Secondly, we use this contraction to derive the optimal complexity of the AFEM. The results are based on ideas from the paper by Diening and Kreuzer and extend the theory from Cascón et. al. to a class of nonlinear problems which stem from strongly monotone and Lipschitz operators.","palabras_clave":"nonlinear elliptic equations|adaptive finite element methods|optimality"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87789,"idioma_id":4,"titulo":"Thompson type formulae","resumen":"Let X and Y be two n times n Hermitian matrices. In the article 'Proof of a conjectured exponential formula' (Linear Multilinear Algebra 19 (1986) (187?197) R.C. Thompson proved that there exist two n times n unitary matrices U and V such that exp(iX) exp(iY) = exp(iUX adj(U)+VY adj(V)),(where adj(.) denotes de adjoint operator). In this note we consider extensions of this result to compact operators as well as to operators in an embeddable II1 factor.","palabras_clave":"operator identity|unitary operator|compact operator|von Neumann finite algebra"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87790,"idioma_id":4,"titulo":"A characterization of minimal Hermitian matrices","resumen":"We describe properties of a n times n Hermitian matrix M having minimal quotient norm in the following sense:&nbsp; norm(M) less or equal to norm(M + D), for all real diagonal matrices D. Here norm( . ) denotes the operator norm. We show a constructive method to obtain all the minimal matrices of any size.","palabras_clave":"minimal matrix|hermitian matrix|positive matrix|conditional expectations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87791,"idioma_id":4,"titulo":"Finite element modelling of heat transfer in Shaped Metal Deposition and experimental validation","resumen":"Shaped Metal Deposition (SMD) is a novel technology for building near-netshaped components by successive layer deposition using a welding machine. TheSMD rig consists of a robot with a tungsten inert gas (TIG) welding torch andmanipulator, both of which are housed inside a sealed chamber. A series of wallswere made by SMD with a Ti-6Al-4V alloy and the heat transfer problem duringlayer deposition was analysed in all cases. The specimens were built for a widerange of process parameters (number of layers, layer height, wire feed rate, travelspeed, heat input, etc.) and wall dimensions. During the fabrication process, the SMD built part is subjected repeatedly to high temperature gradients and high heating and cooling rates, resulting in a unique morphology and microstructures usually not observed in conventional fabrication techniques. A finite element model for the thermal analysis of this deposition process was constructed. The aims of this study are, firstly, to correlate the predicted temperature field to experimental observations to validate the numerical model of such a complex process; and secondly, to explain on the basis of the computed temperature and temperature rate the appearance of characteristic microstructures in the top of the walls, the substrate and the intermediate region.","palabras_clave":"SHAPED METAL DEPOSITION|FINITE ELEMENTS|TEMPERATURE EVOLUTION|MICROSTRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87793,"idioma_id":4,"titulo":"Light-Activated Gating and Permselectivity in Interfacial Architectures Combining 'Caged' Polymer Brushes and Mesoporous Thin Films","resumen":"We demonstrate that ??caged?? macromolecular building blocks can endow mesoporous thin films with light responsiveness and lead to the creation of functional hybrid ensembles with phototriggered permselective properties.","palabras_clave":"Polymer brushes|Materiales mesoporosos|Química Supramolecular|Materiales Fotoactivos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87794,"idioma_id":10,"titulo":"Phototunable Response in Caged Polymer Brushes","resumen":"A light-responsive brush was obtained by surface-initiated ATRP of a methacrylate monomer containing ionizable &#8722;COOH side groups caged with the photoremovable group 4,5-dimethoxy-2-nitrobenzyl (NVOC). In the caged form, the polymer brush (PNVOCMA) is neutral and hydrophobic due to the presence of the aromatic chromophore. Upon irradiation the NVOC group is removed and a polyanion (polymethacrylic acid, PMAA) chain is generated. The charged brush can swell and collapse depending on the pH and the exposure dose (i.e., uncaging degree). The behavior and properties of the brush layer for different photoconversion degrees were studied. On the basis of quartz crystal microbalance measurements, a threshold of 50% uncaging was identified in order to achieve significant swelling and pH response of the brush. Between 50 and 80% the photoconversion the response of the brush could be light-modulated. For photoconversions &gt;80% only small changes in the response were detectable. X-ray reflectivity (XRR) and scanning force microscopy allowed us to measure thickness, roughness and swelling of the brushes at intermediate photoconversions. Combined XRR and grazing-incidence small-angle scattering experiments evidenced a change in the internal structure of the brush upon exposure and indicated the occurrence of domain segregation as a consequence of the coexistence of hydrophobic and charged groups in the brush structure.","palabras_clave":"Química macromolecular|Polymer brushes|Polymer thin films|Materiales fotoactivos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87795,"idioma_id":4,"titulo":"Molecular Transport in Thin Thermo-Responsive Poly(N-isopropylacrylamide) Brushes with Varying Grafting Density","resumen":"The effect of the grafting density on the molecular  transport through thermoresponsive brushes of poly(Nisopropylacrylamide)  (PNIPAM) grafted onto flat gold substrates  was investigated using voltammetry and impedance  spectroscopy. PNIPAM brush layers were synthesized at four  different grafting densities using surface-initiated atom transfer  radical polymerization (SI-ATRP) from mixed self-assembled  monolayers of omega-mercaptoundecyl bromoisobutyrate and undecanethiol  chemisorbed on gold surfaces. Tethered PNIPAM  layers with grafting densities resulting from initiator concentrations  lower than 25% in the thiol monolayer show the same  transport properties as the initial self-assembled monolayer  before brush synthesis. For higher grafting densities, the diffusion  coefficients, D, of the K3[Fe(CN)6]\/K4[Fe(CN)6] redox  probe is 7 orders of magnitude smaller than those typically measured in aqueous solutions and independent of whether the brush  is collapsed or swollen. The collapse of the PNIPAM brush drives a hydrophilic\/hydrophobic transition in addition to structural\/  conformational transformations of the grafted layers, resulting in still smaller values of D. However, these changes do not lead to  a blocking effect on the active area of the gold surface, which is only determined by pinholes or discontinuities in the thiol  initiator monolayer. These results are only observed for thin PNIPAM brush layers.","palabras_clave":"Polymer Brushes|Macromolecular assemblies|Electrochemical interfaces|Molecular transport"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87796,"idioma_id":4,"titulo":"In vitro evaluation of preabsorptive events of dispersed supramolecular aggregates by dynamic light scattering. Oral multivitamin formulations as a model case.","resumen":"In order to develop an approach to evaluate the preabsorptive behavior of supramolecular aggregate carriers, three commercial oral formulations of a mixture of lipophilic and hydrophilic vitamins dispersed in water-glycerin-polysorbate-80 (PS-80) vehicle were subjected to dynamic light scattering and electrokinetic determinations. They exhibited diffusion coefficients ranging from 4.46 .10-9 to 3.22 .10-8 cm2\/s. To mimic in vivo environment the formulations were progressively diluted with water and simulated gastric and intestinal fluids until a ratio 1:10. Hydrodynamic diameters (dH) at 37°C and electrokinetic potentials of each formulation remained almost unchanged in the three assayed conditions. However, the average dH were 1.00, 1.36 and 1.63 times higher than a reference dispersion of PS-80 revealing significant differences among formulations. Concentration of PS-80 in diluted samples is about 103 times above its critical micellar concentration. Therefore, loaded core\/shell micelles appears to be robust drug carriers that will interact with the gastrointestinal membranes upon administration. The observed differences in size and\/or shape would be related to the biopharmaceutical performance of multisource products. Besides, the developed approach could be used in developing and control stages of such pharmaceutical systems.","palabras_clave":"Dynaic ligth scattering |in vitro test|oral multivitamins |preabsortive events|supramolecular aggregates"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87797,"idioma_id":4,"titulo":"Equilibrium and Release Properties of Aqueous Dispersions of Non Steroidal Antiinflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100","resumen":"Equilibria and release properties of aqueous systems consisting of a set of five non-steroidal anti-inflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported in this study. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A&#8722; and Cl&#8722;) produces clear, stable aqueous dispersions in which a remarkably high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes toward a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behaved as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.","palabras_clave":"Eudragit E100®|NSAID|Complexes|Drug delivery"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87798,"idioma_id":4,"titulo":"Studies of  pilocarpine:carbomer intermolecular interactions","resumen":"The interactions between pilocarpine (PIL) and the anionic polyelectrolyte carbomer (CBR) were investigated. The effects of the chemical interactions on the chemical stability of the drug also were evaluated. The binary system was characterized by nuclear magnetic resonance techniques, fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy and thermal analysis. The experiments showed that the complex, prepared by freeze-drying, is a solid amorphous form different from its precursors, thereby offering an interesting alternative for the preparation of extended release matrices. The solution stability of PIL was studied at pH 7 and 8, at 70 ºC. The PIL solution stability was evaluated alone and in the presence of CBR. Results indicated that the drug in the presence of the polymer is 3.3 and 3.5 times more stable, at pH 7 and pH 8, respectively, than the drug without CBR. The activation energy and the frequency factor, according to Arrhenius plot, were estimated to be 13.9 ± 0.4 and 14.8 ± 0.5 kcal mol&#8722;1, and 6.1 ± 0.3 and 7.6 ± 0.3, with and without the polymer, respectively.","palabras_clave":"pilocarpine|carbomer|drug stability|NMR spectroscopy|thermal analysis|FTIR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87799,"idioma_id":4,"titulo":"Self-organized nanoparticles based on drug-interpolyelectrolyte complexes as potential drug carriers: Physicochemical and in vitro drug release evaluations","resumen":"Potential applications in drug delivery from nanostructures comprised of two oppositely charged polymethacrylates, eudragit® L100 (EL) and eudragit® EPO (EE), loaded with three model basic drugs (D), atenolol, propranolol and metroclopramide were evaluated. The self-organized nanoparticles based on drug-interpolyelectrolyte complexes (DIPEC), (EL-D50)-EEX, were obtained by mixing the aqueous dispersions of both polyelectrolytes at room temperature in an ultrasound bath. Dispersions of (EL-D50) neutralized with increasing proportions of EE exhibited a rise of turbidity, diffusion coefficients  in the range of 2 to 8.10-8 cm2\/s and high negative zeta potential . The sign of zeta potential was shifted from negative to positive by changes in composition of DIPEC. Freeze dried DIPEC were easily redispersed in water yielding almost the same parameters of fresh dispersions. Release experiments in Franz cells shown that DIPEC systems behave as a drug reservoir that slowly releases the drug in water. The release rate was raised by ionic exchange with counterions present in simulated physiological fluids placed in the receptor media.  Delivery of D from DIPEC exhibited a remarkable robustness towards biorrelevant media of different pH.","palabras_clave":"Drug-interpolyelectrolyte complexes|Eudragit L100 and EPO |drug carrier|self-organizing nanoparticles|controlled release"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87800,"idioma_id":4,"titulo":"Modelling drug release from a layered double hydroxide-ibuprofen complex","resumen":"Drug delivery by layered double hydroxides (LDHs) is extensively studied due to the capacity of these solids to preserve the active agent and to modify its release rate and bioavailability. In this work, an ibuprofen\u2013LDH complex was synthesized with high drug content (54% w\/w), incorporated both in the interlayer and on the surface. The mechanisms involved in the ibuprofen release process were studied as a function of the anion type (chloride, acetate, and phosphate) and concentration, and the pH of the releasemedia. The experimental conditions selected were based on the composition of pharmaceutically relevant fluids such as gastric, intestinal and lysosomal simulated media. Three release mechanisms accounted for the rate and extent of the drug release: ion exchange (highly dependent on the anions), desorption and weathering (dependent on the pH).   These mechanisms, together with the different solubility of the anionic and non-ionic ibuprofen species, also explained the release behavior for particulate solid and hydrogel formulations. Anion exchange determined ibuprofen release in intestinal medium (phosphate anions pH 6.8) whereas surface reactions mediated by solid weathering or drug solubility ruled the release in acid media (gastric fluid and lysosomal medium).","palabras_clave":"Layered double hydroxides|controlled release|Ibuprofen|mechanism|kinetic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87801,"idioma_id":4,"titulo":"Eudragit E100(®) potentiates the bactericidal action of ofloxacin against fluoroquinolone-resistant Pseudomonas aeruginosa.","resumen":"We report the enhanced bactericidal activity of ofloxacin in drug-containingEudragit E100® dispersions (EuCl-OFX) against Pseudomonas aeruginosa andthe effect of the cationic polymer on bacterial membrane. Organisms treatedwith EuCl-OFX showed changes in cell morphology, altered outer membrane(OM) and cytoplasm with low electrodensity areas. Zeta potential of bacterialsurface was shifted to positive. Sensitization to lytic agents was also observed.A profound effect on bacterial size, granularity and membrane depolarizationwas found by flow cytometry. Cultures exposed to drug-free polymer alsoshowed some damaged bacterial membranes, but there was no significant celldeath. Inhibition of P. aeruginosa by EuCl-OFX may involve surface effect and,to some extent, permeation effect. The cationic polymer act to mitigate theelectronegativity of cell surface in the process of disorganizing the OM, render-ing it more permeable to antibiotic. In addition, cytoplasmic membrane depo-larization turns bacterial cell more vulnerable. The effects on membranescombined with the mechanism of action of quinolone explain the improvedbactericidal action exhibited by EuCl-OFX. The behavior described for EudragitE100® against P. aeruginosa may be a useful tool to broaden the spectrum ofantibiotics whose clinical use is limited by the impermeability of the bacterialOM.","palabras_clave":"CATIONIC POLYMER|MEMBRANE DEPOLARIZATION|EUDRAGIT|ZETA POTENTIAL|FLOW CYTOMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87802,"idioma_id":4,"titulo":"SAR Analysis of New Dual Targeting Fluoroquinolones. Implications of the Benzenesulfonyl Group","resumen":"When a benzenesulfonyl moiety (BS) was bound to the N-piperazinyl ring of antibacterial fluoroquinolones (AMFQs) norfloxacin (NOR) or ciprofloxacin (CIP), the resulting benzenesulfonyl-fluoroquinolone (BSFQs) analogs showed an improved in vitro activity against Gram-positive strains. A bioisosterical replacement of the sulfonyl group for a carbonyl group led to the benzenecarboxamide-fluoroquinolones (BCFQs) that showed a similar trend in the antibacterial activity and spectrum. The BSFQs and BCFQs are considered members of the 'dual targeting' fluoroquinolones, targeting both DNA gyrase and topoisomerase IV. To disclose the real contribution of the BS\/BC moiety in antistaphylococcal activity, a 3D-QSAR analysis that included calculation of theoretical molecular descriptors and pharmacophore generation was performed. Previous and present QSAR results have confirmed the positive influence on activity of small electron donating p-substituent on the BS or BC moiety. The generated phamacophore model showed that both phenyl and SO 2\/CO groups are involved in the interaction with receptor. We postulate that the enhanced potency of BSFQs against Staphylococcus aureus compared to CIP and NOR could be caused by the presence of the BS moiety that resulted in enhanced binding to DNA gyrase of Sa. Additionally, their greater ability to enter bacterial cells by diffusion and a reduced susceptibility to FQ-specific efflux pumps could also make a contribution","palabras_clave":"Benzenesulfonyl group|conformational analysis|fluoroquinolones,|pharmacophore,|QSAR."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87803,"idioma_id":4,"titulo":"Self-Assembly of Thiolated Cyanine Aggregates on Au(111) and Au Nanoparticle Surfaces","resumen":"Heptamethinecyanine J-aggregates display sharp, intense fluorescence emission making them attractive candidates for developing a variety of chem-bio-sensing applications. They have been immobilized on planar thiol-covered Au surfaces and thiol-capped Au nanoparticles by weak molecular interactions. In this work the self-assembly of novel thiolated cyanine (CNN) on Au(111) and citrate-capped AuNPs from solutions containing monomers and J-aggregates has been studied by using STM, XPS, PM-IRRAS, electrochemical techniques and Raman spectroscopy. Data show that CNN species adsorb on the Au surfaces by forming thiolate-Au bonds. We found that the J-aggregates are preferentially adsorbed on the Au(111) surface directly from the solution while adsorbed CNN monomers can not organize into aggregates on the substrate surface. These results indicate that the CNN-Au interaction is not able to disorganize the large J-aggregates stabilized by &#960;-&#960; stacking to optimize the S-Au binding site but it is strong enough to hinder the &#960;-&#960; stacking when CNN are chemisorbed as monomers. The optical properties of the J-aggregates remain active after adsorption. The possibility of covalently bonding CNN J- aggregates to Au planar surfaces and Au nanoparticles controlling the J-aggregates\/Au distance opens a new path regarding their improved stability and the wide range of biological applications of both CNN and AuNP biocompatible systems.","palabras_clave":"Nanoparticulas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87804,"idioma_id":4,"titulo":"Diesel particulate matter combustion with CeO2 as catalyst. Part I: system characterization and reaction mechanism","resumen":"In this work, a reaction mechanism for the catalytic combustion of diesel soot on cerium oxide is proposed. Kinetic results and catalyst characterization by Fourier-transformed Infra-Red spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscopy (SEM), X-ray Diffraction Spectroscopy (XRD), and high frequency CO2 pulses are used to obtain such mechanism. Temperature-programmedoxidationexperiments carried out up to intermediate temperatures made it possible to detect a transient kinetic response, in which a maximum in reaction rate at constant temperature was observed. This behavior is explained taking into account the amount of peroxides formed on the ceria surface. As the calcination temperature increases (from 400 to 800 &#9702;C), the amount of cerium superoxide and peroxide increases, thus accelerating the soot combustion reaction. These compounds were detected by FTIR. Ahigher total oxygen concentration on the ceria surface was detected by XPS on the catalyst calcined at high temperature. Carbon dioxide is not adsorbed on this support. The proposed reaction mechanism involves the formation of superoxides and peroxides. The latter are the active species that react with soot. These steps are strongly affected by temperature, being it possible to explain the kinetic results with this mechanism.","palabras_clave":"diesel soot|oxidation kinetics|cerium oxide|reaction mechanism"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87805,"idioma_id":4,"titulo":"A finite element method for stiffened plates","resumen":"The aim of this paper is to analyze a low order finite element method for a stiffenedplate. The plate is modeled by Reissner-Mindlin equations and the stiffener by Timoshenko beamsequations. The resulting problem is shown to be well posed. In the case of concentric stiffeners itdecouples into two problems, one for the in-plane plate deformation and the other for the bendingof the plate. The analysis and discretization of the first one is straightforward. The second oneis shown to have a solution bounded above and below independently of the thickness of the plate. A discretization based on DL3 finite elements combined with ad-hoc elements for the stiffener is proposed. Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.ad-hoc elements for the stiffener is proposed. Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.ad-hoc elements for the stiffener is proposed. Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.ad-hoc elements for the stiffener is proposed. Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.ad-hoc elements for the stiffener is proposed. Optimal order error estimates are proved for displacements, rotations and shear stresses for the plateand the stiffener. Numerical tests are reported in order to assess the performance of the method.These numerical computations demonstrate that the error estimates are independent of the thickness,providing a numerical evidence that the method is locking-free.","palabras_clave":"STIFFENED PLATES|REISSNER-MINDLIN MODEL|TIMOSHENKO BEAM|FINITE ELEMENTS|ERROR ESTIMATES|LOCKING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87806,"idioma_id":4,"titulo":"The ubiquitin-activating enzyme (E1) of the early-branching eukaryote Giardia intestinalis shows unusual proteolytic modifications and play important roles during encystation","resumen":"Giardia intestinalis is considered an early-branching eukaryote and is therefore a valuable model for studying primordial cellular processes. This work reports the characterization of the ubiquitin-activating enzyme (E1) during growth and different stages of trophozoite differentiation into cysts. We found that in Giardia E1 expression (both at mRNA and protein levels) is regulated during encystation. The enzyme is proteolytically processed mainly into two fragments of 68 kDa (N-terminal) and 47 kDa (C-terminal). This phenomenon has not been described for any other E1. In trophozoites, this enzyme localized at spots within the cytoplasm as detected by using polyclonal antibodies against either E1 N- or C-terminal fragments. This pattern changed during encystation into a diffuse localization throughout the cytoplasm of encysting cells. E1 localizes in mature cysts at cytoplasmic spots and in the cyst wall. Our antisense silencing experiments suggested that E1 is an essential gene for parasite viability. On the other hand, E1 over-expression greatly increased the encystation rate, indicating a relationship between E1 and Giardia differentiation.","palabras_clave":"GIARDIA|ENCYSTATION|UBIQUITIN|PROTEOLYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87807,"idioma_id":4,"titulo":"The Effect of Different Interfaces and Confinement on the Structure of the Ionic Liquid 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide Entrapped in Cationic and Anionic Reverse Micelles","resumen":"The behavior of the ionic liquid (IL) 1-butyl-3-methylimidazolium bis (trifluoromethylsulfonyl) imide ([bmim][Tf2N]) entrapped in two reverse micelles (RMs) formed in an aromatic solvent as dispersant pseudophase: [bmim][Tf2N]\/benzyl-n-hexadecyldimethylammonium chloride (BHDC)\/chlorobenzene and [bmim][Tf2N]\/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)\/chlorobenzene, was investigated using dynamic light scattering (DLS), FT-IR and 1H NMR spectroscopies. DLS results reveal the formation of RMs containing [bmim][Tf2N] as a polar component since the droplet sizes values increase as the Ws (Ws = [[bmim][Tf2N]] \/ [surfactant]) increases. Furthermore, it shows that the RMs consist of discrete spherical and non-interacting droplets of [bmim][Tf2N] stabilized by the surfactants. Important differences in the structure of [bmim][Tf2N] entrapped inside BHDC RMs, in comparison with the neat IL, are observed from the FT-IR and 1H NMR measurements. The electrostatic interactions between anions and cations from [bmim][Tf2N] and BHDC determine the solvent structure encapsulated inside the nano-droplets. It seems that the IL structure is disrupted due to the electrostatic interaction between the [Tf2N]- and the cationic BHDC polar head (BHD+) giving a high ion pair degree between BHD+ and [Tf2N]- at low IL content. On the other hand, for the AOT RMs there are no evidences of strong IL ? surfactant interaction. The electrostatic interaction between the SO3- group and Na+ counterion in AOT seems to be stronger than the possible [bmim]+ - SO3- interaction at the interface. Thus, the structure of [bmim][Tf2N] encapsulated is not particularly disrupted by the anionic surfactant at all Ws studied, in contrast to the BHDC RMs results. Nevertheless, there are evidences of confinement in the AOT RMs because the [bmim]+ - [Tf2N]- interaction is stronger than in bulk solution. Thus, the IL is more associated upon confinement. Our results reveal that the [bmim][Tf2N] structure can be modified in different manner inside RMs by varying the kind of surfactant used to create the RMs and the IL content (Ws). These facts can be very important if these media are used as nanoreactors because unique microenvironments can be easily created simply changing the RMs components and Ws. ","palabras_clave":"IONIC LIQUIDS|REVERSE MICELLES|NANOSCIENCES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87808,"idioma_id":4,"titulo":"C343 behavior in benzene\/AOT reverse micelles. The role of the dye solubilization in the non-polar organic pseudophase","resumen":"The behavior of coumarin 343 (C343), a common molecular probe utilized in solvation dynamics experiments, was studied in water\/sodium 1,4-bis-2-ethylhexylsulfosuccinate (AOT)\/benzene reverse micelles (RMs). In all the studies performed until now, C343 was not soluble in the organic solvent used to create the RMs systems (namely different alkanes such as n-heptane, cyclohexane or isooctane). In this work we have chosen benzene as the organic solvent because C343 is completely soluble at the work concentration used (~10-6 M). Thus, a well known AOT RMs system: benzene\/AOT\/water has been used in order to gain insights, for the first time, on how the RMs formation can affect the C343 spectroscopic behavior. Dissolved in pure benzene C343 exists as a dimer since the intermolecular H-bond interactions are very strong in this solvent. When introduced to the AOT RMs, C343 resides in the RMs interface and, at low occupation number the probability of finding more than one C343 molecule is reduced and only C343 monomer species is detected. From the spectral changes it was possible to determine the critical micelle concentration at W0 = 0 and 10 and the C343 partition constants between two pseudophases. In summary, in this work we have shown how the spectroscopic behavior of C343 is dramatically altered because the partition of the dye to the AOT RMs interfaces.","palabras_clave":"AOT|C343|NANOSCIENCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87809,"idioma_id":4,"titulo":"Nonaqueous Polar Solvents in Reverse Micelle Systems","resumen":"Water?s ability to interact with itself and other molecules through a number of intermolecular interactions includinghydrogen bonding leads to interesting and useful assemblies ofmolecules in a wide range of naturally occurring systems fromthe precise folding of proteins to the winding of DNA on achromatin core to the organization of millions of lipids intosheets that delineate the inside and outside of a cell. In nature,water plays a key role for self-assembly; in the laboratoryresearchers seek motifs that arise in nonaqueous solutions toprovide new media for chemistry. The self-assembly ofamphiphiles in the absence of water forms the focus of thisreview. In particular, we discuss the assembly of amphiphilesinto microemulsions and reverse micelles in nonpolar solventswhile sequestering a polar nonaqueous core.through a number of intermolecular interactions includinghydrogen bonding leads to interesting and useful assemblies ofmolecules in a wide range of naturally occurring systems fromthe precise folding of proteins to the winding of DNA on achromatin core to the organization of millions of lipids intosheets that delineate the inside and outside of a cell. In nature,water plays a key role for self-assembly; in the laboratoryresearchers seek motifs that arise in nonaqueous solutions toprovide new media for chemistry. The self-assembly ofamphiphiles in the absence of water forms the focus of thisreview. In particular, we discuss the assembly of amphiphilesinto microemulsions and reverse micelles in nonpolar solventswhile sequestering a polar nonaqueous core.?s ability to interact with itself and other molecules through a number of intermolecular interactions includinghydrogen bonding leads to interesting and useful assemblies ofmolecules in a wide range of naturally occurring systems fromthe precise folding of proteins to the winding of DNA on achromatin core to the organization of millions of lipids intosheets that delineate the inside and outside of a cell. In nature,water plays a key role for self-assembly; in the laboratoryresearchers seek motifs that arise in nonaqueous solutions toprovide new media for chemistry. The self-assembly ofamphiphiles in the absence of water forms the focus of thisreview. In particular, we discuss the assembly of amphiphilesinto microemulsions and reverse micelles in nonpolar solventswhile sequestering a polar nonaqueous core.","palabras_clave":"REVIEW|NONAQUEOUS|REVERSE MICELLES|AOT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87810,"idioma_id":4,"titulo":"Organized thiol functional groups in mesoporous core shell colloids","resumen":"The co-condensation in situ of tetraethoxysilane (TEOS) and mercaptopropyltrimethoxysilane (MPTMS) using cetyltrimethylammonium bromide (CTAB) as a template results in the synthesis of multilayered mesoporous structured SiO2 colloids with \u201Conion-like\u201D chemical environments. Thiol groups were anchored to an inner selected SiO2 porous layer in a bilayered core shell particle producing different chemical regions inside the colloidal layered structure. X-Ray Photoelectron Spectroscopy (XPS) shows a preferential anchoring of the \u2013SH groups in the double layer shell system, while porosimetry and simple chemical modifications confirm that pores are accessible. We can envision the synthesis of interesting colloidal objects with defined chemical environments with highly controlled properties.","palabras_clave":"core shell|colloids|mesoporous materials"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87811,"idioma_id":4,"titulo":"Some Evidence for the Formation of an Azo Bond during the Electroreduction of Diazonium Salts on Au Substrates","resumen":"Molecular films obtained by electrochemical reduction of diazoniuimtetrafluoroborate salts [4-carboxybenzene (PhCOOH)and 4-amino-(2,3,5,6-tetrafluoro)-carboxybenzene (PhF4COOH)]on Au substrates and post-functionalization with an osmiumpyridil-bipyridine complex are studied by a combination of Xrayphotoelectron (XPS) and polarization-modulation infraredreflection absorption spectroscopy (PM-IRRAS). The spectroscopicevidence suggests the formation of N=N bonds tetheringthe complexes to Au. The surface coverage of the azobondedosmium complexes strongly depends on the electrodepotential. The resulting tethered osmium redox centres werecharacterized by cyclic voltammetry and impedance spectroscopy.Similar electron transfer-rate constants were measuredfor both fluorinated and non fluorinated benzene-linked Oscomplexes.4COOH)]on Au substrates and post-functionalization with an osmiumpyridil-bipyridine complex are studied by a combination of Xrayphotoelectron (XPS) and polarization-modulation infraredreflection absorption spectroscopy (PM-IRRAS). The spectroscopicevidence suggests the formation of N=N bonds tetheringthe complexes to Au. The surface coverage of the azobondedosmium complexes strongly depends on the electrodepotential. The resulting tethered osmium redox centres werecharacterized by cyclic voltammetry and impedance spectroscopy.Similar electron transfer-rate constants were measuredfor both fluorinated and non fluorinated benzene-linked Oscomplexes.=N bonds tetheringthe complexes to Au. The surface coverage of the azobondedosmium complexes strongly depends on the electrodepotential. The resulting tethered osmium redox centres werecharacterized by cyclic voltammetry and impedance spectroscopy.Similar electron transfer-rate constants were measuredfor both fluorinated and non fluorinated benzene-linked Oscomplexes.","palabras_clave":"diazonium|electroreduccion|PM-IRRAS|XPS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87812,"idioma_id":4,"titulo":"Recognition between a short unstructured peptide and a partially folded fragment leads to the thioredoxin fold sharing native-like dynamics","resumen":"Thioredoxins (TRXs) constitute attractive &#945;\/&#946; scaffolds for investigating molecular recognition. The interaction between the recombinant fragment spanning the sequence 1-93 of full-length TRX (TRX1-93) and the synthetic peptide comprising residues 94-108 (TRX94-108), plus a C-terminal tyrosine tag (the numbering scheme used in entry pdb 2TRX is used throughout the article, two complementary moieties of E. coli TRX, brings about the consolidation of a native-like complex. Despite its reduced thermodynamic stability, this complex is able to acquire fine structural features remarkably similar to those characteristic of full-length TRX, namely, hydrodynamic behavior, assessed by diffusion-ordered spectroscopy (DOSY)-NMR; the pattern of secondary structure, as revealed by three-bond HNH&#945; coupling constants and secondary shifts for H&#945;\/CO\/C&#945;\/C&#946;; native-like tertiary structural signatures revealed by near-UV circular dichroism (CD) spectroscopy. The complex exhibits a relaxation behavior compatible with that expected for a native-like structure. However, heteronuclear nuclear Overhauser effect (NOE)s reveal an enhanced dynamics for the complex by comparison with full-length TRX. Furthermore, higher R(2) values for residues 43-50 and 74-89 would likely result from an exchange process modulated by the peptide at the interface region. The slow kinetics of the consolidation reaction was followed by CD and real-time NMR. Equilibrium titration experiments by NMR yield a K(D) value of 1.4 ± 1.0 &#956;M and a second low-affinity (>150 &#956;M) binding event in the vicinity of the active site. Molecular dynamics simulations of both the isolated fragment TRX1-93 and the complex suggest the destabilization of &#945;2 and &#945;3 helical elements and the persistence of &#946;-structure in the absence of TRX94-108. Altogether, structural and dynamic evidence presented herein points to the key role played by the C-terminal helix in establishing the overall fold. This critical switch module endows reduced TRX with the ability to act as a cooperative folding unit","palabras_clave":"THIOREDOXIN|PROTEIN FOLDING|NMR|MOLECULAR DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87813,"idioma_id":4,"titulo":"Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease","resumen":"Alpha-synuclein (AS) aggregation is associated with neurodegeneration in   Parkinson´s disease (PD). At the same time, alterations in metal ion   homeostasis may play a pivotal role in the progression of AS amyloid   assembly and the onset of PD. Elucidation of the structural basis   directing AS-metal interactions and their effect on AS aggregation   constitutes a key step toward understanding the role of metal ions in AS   amyloid formation and neurodegeneration. This work provides a   comprehensive review of recent advances attained in the bioinorganic   chemistry of AS amyloid diseases. A hierarchy in AS-metal ion   interactions has been established: while the physiologically relevant   divalent metal ions iron and manganese interact at a non-specific,   low-affinity binding interface in the C-terminus of AS, copper binds   with high affinity at the N-terminal region and it is the most effective   metal ion in accelerating AS filament assembly. The strong link between   metal binding specificity and its impact on aggregation is discussed   here on a mechanistic basis. A detailed description of the structural   features and coordination environments of copper to AS is presented and   discussed in the context of oxidative cellular events that might lead to   the development of PD. Overall, the research observations presented   here support the notion that perturbations in copper metabolism may be a   common upstream event in the pathogenesis of neurodegenerative   processes.","palabras_clave":"STRUCTURAL BIOLOGY|BIOINORGANIC CHEMISTRY|AMYLOID|PARKINSON´S DISEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87814,"idioma_id":4,"titulo":"Sex-related difference in left ventricular mass in non-hypertensive young adults: role of arterial pressure.","resumen":"Abstract      BACKGROUND:       Blood pressure (BP) is higher   in men than in women at similar ages through adult life. Interestingly, a   similar pattern is detected in left ventricular mass (LVM), classically   attributed to differences in body size. However, the existing   difference in BP between sexes might be relevant in determining LVM and   it has been not fully investigated. Therefore, we set out to determine   the impact of nonhypertensive levels of BP on the sex-associated LVM   difference.      METHODS:       We conducted population-based study   including 283 young students (52% male; age 20.62 ± 1.31 years). BP was   determined twice using standard mercury sphygmomanometers in 2   occasions. LVM was determined with M-mode echocardiography. To dissect   the relative contribution of BP, volume load, and body size to the   sex-related difference in LVM, an analysis of covariance was performed.      RESULTS:       Mean   systolic and diastolic BP were 10.00 ± 0.96 and 4.59 ± 0.78 mm Hg   higher and LVM was 34.87 ± 3.12 g larger in men than in women,   respectively (P &lt; 0.01, t test). When LVM was adjusted to mean BP,   the sex difference was reduced by 16%. When LVM was adjusted to body   size and hemodynamic load, this difference was reduced by 68.5%.      CONCLUSIONS:       We   report in a sample of young nonhypertensive students a difference in   LVM between women and men that is partially explained (16%) by sex   differences in BP, supporting an early effect of BP on cardiac mass even   in the absence of hypertension. A more relevant effect could be   expected as the population ages.","palabras_clave":"left ventricular mass|young|non-hypertensive|sex-related differences"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87815,"idioma_id":4,"titulo":"Trypanosoma cruzi trans-Sialidase in Complex with a Neutralizing Antibody: Structure\/Function Studies Towards the Rational Design of Inhibitors","resumen":"Trans-sialidase (TS), a virulence factor from Trypanosoma cruzi,   is an enzyme playing key roles in the biology of this protozoan   parasite. Absent from the mammalian host, it constitutes a potential   target for the development of novel chemotherapeutic drugs, an urgent   need to combat Chagas´ disease. TS is involved in host cell invasion and   parasite survival in the bloodstream. However, TS is also actively shed   by the parasite to the bloodstream, inducing systemic effects readily   detected during the acute phase of the disease, in particular,   hematological alterations and triggering of immune cells apoptosis,   until specific neutralizing antibodies are elicited. These antibodies   constitute the only known submicromolar inhibitor of TS´s catalytic   activity. We now report the identification and detailed characterization   of a neutralizing mouse monoclonal antibody (mAb 13G9), recognizing T. cruzi TS with high specificity and subnanomolar affinity. This mAb displays undetectable association with the T. cruzi superfamily of TS-like proteins or yet with the TS-related enzymes from Trypanosoma brucei or Trypanosoma rangeli.   In immunofluorescence assays, mAb 13G9 labeled 100% of the parasites   from the infective trypomastigote stage. This mAb also reduces parasite   invasion of cultured cells and strongly inhibits parasite surface   sialylation. The crystal structure of the mAb 13G9 antigen-binding   fragment in complex with the globular region of T. cruzi TS was   determined, revealing detailed molecular insights of the inhibition   mechanism. Not occluding the enzyme´s catalytic site, the antibody   performs a subtle action by inhibiting the movement of an assisting   tyrosine (Y119), whose mobility is known to play a key role in the trans-glycosidase   mechanism. As an example of enzymatic inhibition involving   non-catalytic residues that occupy sites distal from the   substrate-binding pocket, this first near atomic characterization of a   high affinity inhibitory molecule for TS provides a rational framework   for novel strategies in the design of chemotherapeutic compounds.","palabras_clave":"VIRULENCE FACTORS|CHAGAS DISEASE|TRYPANSOMA CRUZI|SIALIDASES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87816,"idioma_id":4,"titulo":"Redundant and antagonistic functions of galectin-1, -3 and -8 in the elicitation of T cell responses","resumen":"Galectins, a family of mammalian lectins, have emerged as key regulators of the immune response. We previously demonstrated that galectin (Gal)-8, from the tandem-repeat subgroup, exerts two well-defined effects on mouse naive peripheral CD4 T cells: Ag-specific costimulation and Ag-independent proliferation. These stimulatory signals on naive T cells have not been described for any other Gal. Therefore, we investigated whether Gal-1 and Gal-3, two prominent members of the Gal family, share the stimulatory effects exerted by Gal-8 on naive T cells. We found that Gal-1 costimulated Ag-specific T cell responses similarly to Gal-8, as evaluated in the DO11.10 TCROVA-transgenic mouse model, by acting simultaneously on APCs and target CD4 T cells. In contrast, Gal-3 failed to costimulate Ag-specific T cell responses; moreover, it antagonized both Gal-1 and Gal-8 signals. We observed that both Gal-1 and Gal-3 were unable to induce Ag-independent proliferation; however, when two Gal-1 molecules were covalently fused, the resulting chimeric protein efficiently promoted proliferation. This finding indicates that Gal-1 might even- tually induce proliferation and, moreover, stresses the requirement of a tandem-repeat structure. Remarkably, a single dose of recombinant Gal-1 or Gal-8 administered together with a suboptimal Ag dose to DO11.10 mice strengthened weak responses in vivo. Taken together, these findings argue for the participation of Gals in the initiation of the immune response and allow the postulation of these lectins as enhancers of borderline Ag responses, thus representing potential adjuvants for vaccine for- mulations.","palabras_clave":"GALECTINS|CROSS TALK|IMMUNE RESPONSE-ENHANCERS|ANTAGONIC SIGNALLING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87817,"idioma_id":4,"titulo":"Analytical characterization of wine and its precursors by capillary electrophoresis","resumen":"The accurate determination of marker chemical species in grape, musts, and winespresents a unique analytical challenge with high impact on diverse areas of knowledgesuch as health, plant physiology, and economy. Capillary electromigration techniqueshave emerged as a powerful tool, allowing the separation and identification of highly polarcompounds that cannot be easily separated by traditional HPLC methods, providingcomplementary information and permitting the simultaneous analysis of analytes withdifferent nature in a single run. The main advantage of capillary electrophoresis overtraditional methods for wine analysis is that in most cases samples require no treatmentother than filtration. The purpose of this article is to present a revision on capillary electromigrationmethods applied to the analysis of wine and its precursors over the last decade.The current state of the art of the topic is evaluated, with special emphasis on the naturalcompounds that have allowed wine to be considered as a functional food. The most representativerevised compounds are phenolic compounds, amino acids, proteins, elementalspecies, mycotoxins, and organic acids. Finally, a discussion on future trends of the roleof capillary electrophoresis in the field of analytical characterization of wines for routineanalysis, wine classification, as well as multidisciplinary aspects of the so-called ?from soilto glass? chain is presented","palabras_clave":"AMINO ACIDS|CAPILLARY ELECTROMIGRATION METHODS|ELEMENTAL SPECIES|MYCOTOXINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87818,"idioma_id":4,"titulo":"Exploiting the Campylobacter jejuni protein  glycosylation system for glycoengineering  vaccines and diagnostic tools directed against  brucellosis","resumen":"BackgroundImmune responses directed towards surface polysaccharides conjugated to proteins are effective in preventing colonization and infection of bacterial pathogens. Presently, the production of these conjugate vaccines requires intricate synthetic chemistry for obtaining, activating, and attaching the polysaccharides to protein carriers. Glycoproteins generated by engineering bacterial glycosylation machineries have been proposed to be a viable alternative to traditional conjugation methods.ResultsIn this work we expressed the C. jejuni oligosaccharyltansferase (OTase) PglB, responsible for N-linked protein glycosylation together with a suitable acceptor protein (AcrA) in Yersinia enterocolitica O9 cells. MS analysis of the acceptor protein demonstrated the transfer of a polymer of N-formylperosamine to AcrA in vivo. Because Y. enterocolitica O9 and Brucella abortus share an identical O polysaccharide structure, we explored the application of the resulting glycoprotein in vaccinology and diagnostics of brucellosis, one of the most common zoonotic diseases with over half a million new cases annually. Injection of the glycoprotein into mice generated an IgG response that recognized the O antigen of Brucella, although this response was not protective against a challenge with a virulent B. abortus strain. The recombinant glycoprotein coated onto magnetic beads was efficient in differentiating between naïve and infected bovine sera.ConclusionBacterial engineered glycoproteins show promising applications for the development on an array of diagnostics and immunoprotective opportunities in the future.","palabras_clave":"Brucellosis diagnostics|glycoengineering| Yersinia enterocolitica O9| N-linked protein glycosylation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87819,"idioma_id":4,"titulo":"Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease.","resumen":"Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson's disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson's disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~&nbsp;1&nbsp;Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5&nbsp;Hz cortical oscillations falls to negligible levels and oscillations at 10?20&nbsp;Hz are markedly attenuated, whereas beta synchronization (with a peak at ~&nbsp;26&nbsp;Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson's disease symptoms by showing that they are related to each other.","palabras_clave":"striatum|NMDA receptor|Parkinson's disease|Globus pallidus|Neuronal synchronization|Neuronal phase locking"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87820,"idioma_id":4,"titulo":"Overexpression, purification, and biochemical and spectroscopic characterization of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper center with nitrite and NO","resumen":"                Title: Overexpression, purification, and biochemical and spectroscopic characterization   of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the   interaction of the catalytic copper center with nitrite and NO  Journal of Inorganic Biochemistry  Dear Dr. Alberto Rizzi,  I am pleased to inform you that your manuscript 'Overexpression, purification, and   biochemical and spectroscopic characterization of copper-containing nitrite reductase   from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper   center with nitrite and NO' has been accepted for publication in Journal of Inorganic   Biochemistry. I look forward to including your paper in a future Issue of the Journal.  If there are any final comments from the Editor and\/or the Reviewers, they can be found   below.  Thank you for submitting your work to this journal.  With kind regards,  John Dawson  Editor  Journal of Inorganic Biochemistry","palabras_clave":"Nitrite  |Sinorhizobium meliloti 2011|Reductase|Spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87821,"idioma_id":4,"titulo":"On the debate around immanence and transcendence: multitude or the people","resumen":"There has been a profound debate about new ways of looking on emancipatorypolitics among progressive political theoreticians. One of the most important consequences of this contemporary debate has been the emergence of three related controversies: transcendence versus immanence, the people versus the multitude and negative ontology versus positive ontology. Our argumentative strategy will be to present these controversies first, hrough Hardt and Negri?s point of view, and then through a Lacanian lecture of Laclau?s perspective, author who places the psychoanalysis where philosophy traditionally located ontology.","palabras_clave":"IMMANENCE|TRANSCENDENCE|MULTITUDE|THE PEOPLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87822,"idioma_id":4,"titulo":"Oviposition strategies of temporary pool mosquitoes in relation to weather, tidal regime and land use in a temperate wetland","resumen":"Wetlands have traditionally been associated with harbouring mosquitoes, a well-known nuisance and vectors of diseases. Within mosquito life cycle, oviposition is a determinant event by shaping their individual fitness and vectorial capacity. The study was conducted in one of the main temperate wetlands in South America. We used Generalized Linear Models to study the relation between temperature, precipitation, tidal regime, land use, microenvironment, and the occurrence of floodwater (Ochlerotatus and Psorophora spp.) and raft-laying (Culex and Uranotaenia spp.) mosquitoes using temporary pools as larval habitats. Pool occurrence was negatively associated with temperature, and positively related to precipitation and high tides. As regards the land use, it was lowest in domestic areas and plantations, intermediate in secondary forests, and highest in marshes. Each oviposition strategy was best modelled as a function of different environmental factors. The occurrence of floodwater mosquitoes was positively associated with high cumulative precipitation and low tide records. Raft-laying mosquitoes were related to low temperature records, while the effect of flooding varied with the land use. In view of these results, physical (water inputs and movement), chemical, and biological (egg and larval flushing, and predatory interactions) considerations are given to provide insight in the oviposition patterns of mosquitoes occurring in this complex wetland. We finally propose the generation of a tidal flow as a control measure against floodwater mosquitoes, which are the most anthropophilic in the study area.                 ","palabras_clave":"FLOODWATER|RAFT-LAYING|PARANA LOWER DELTA|CULEX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87823,"idioma_id":4,"titulo":"Is temperature the main cause of dengue rise in non endemic countries? The case of Argentina.","resumen":"BackgroundDengue cases have increased during the last decades, particularly in non-endemic areas,and Argentina was no exception in the southern transmission fringe. Althoughtemperature rise has been blamed for this, human population growth, increased traveland inefficient vector control may also be implicated. The relative contribution ofgeographic, demographic and climatic of variables on the occurrence of dengue caseswas evaluated.MethodsAccording to dengue history in the country, the study was divided in two decades, a firstdecade corresponding to the reemergence of the disease and the second includingseveral epidemics. Annual dengue risk was modeled by a temperature-basedmechanistic model as annual days of possible transmission. The spatial distribution ofdengue occurrence was modeled as a function of the output of the mechanistic model,climatic, geographic and demographic variables for both decades.ResultsAccording to the temperature-based model dengue risk increased between the twodecades, and epidemics of the last decade coincided with high annual risk. Denguespatial occurrence was best modeled by a combination of climatic, demographic andgeographic variables and province as a grouping factor. It was positively associatedwith days of possible transmission, human population number, population fall anddistance to water bodies. When considered separately, the classification performance ofdemographic variables was higher than that of climatic and geographic variables.ConclusionsTemperature, though useful to estimate annual transmission risk, does not fully describethe distribution of dengue occurrence at the country scale. Indeed, when takenseparately, climatic variables performed worse than geographic or demographicvariables. A combination of the three types was best for this task.","palabras_clave":"DENGUE|RIESGO|CLIMA|DEMOGRAFIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87824,"idioma_id":4,"titulo":"Immature mosquitoes from ground-water habitats in a temperate wetland of Argentina: environmental associations and seasonal variation of community attributes","resumen":"We studied the seasonal patterns of three community attributes (breeding site index, richness, and diversity) of ground-water mosquito immatures and their associations with meso- and microhabitat factors in the Paraná Lower Delta, Argentina from December 2009 to November 2010.Monthly collections at four sites captured 2,313 mosquito immatures, belonging to 19 species assigned to 6 genera. Immatures developed in a wide range of microenvironmental conditions (water temperature 4.0 - 30.2 ºC, pH 5.4 - 9.1, electric conductivity 0.02 - 6.33 mS\/cm, and dissolved oxygen 0 - 235.6%), and their occurrence was significantly associated with lower water temperature and dissolved oxygen values. Most frequently captured species were Culex dolosuss.l. (58.6% of the samples), Ochlerotatus crinifer (22.9%), and Cx. intrincatus (19.0%). Breeding site index was highest in winter (0.76) and lowest in spring (0.54). Species richness and diversity varied significantly among seasons (peaking in summer), land uses, and habitat types.","palabras_clave":"COMUNITY STRUCTURE|SEASONALITY|LAND USE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87825,"idioma_id":4,"titulo":"A Specific Subpopulation of Mesenchymal Stromal cell carriers overrides melanoma resistance to an oncolytic adenovirus","resumen":"The homing properties of mesenchymal stromal cells (MSCs) toward tumors turn them into attractive tools for combining cell and gene therapy. The aim of this study was to select in a feasible way a human bone marrow-derived MSC subpopulation that might exhibit a selective ability to target the tumor mass. Using differential in vitro adhesive capacities during cells isolation, we selected a specific MSC subpopulation (termed MO-MSCs) that exhibited enhanced multipotent capacity and increased cell surface expression of specific integrins (integrins alpha2, alpha3, and alpha5), which correlated with an enhanced MO-MSCs adhesiveness toward their specific ligands. Moreover, MO-MSCs exhibited a higher migration toward conditioned media from different cancer cell lines and fresh human breast cancer samples in the presence or not of a human microendothelium monolayer. Further in vivo studies demonstrated increased tumor homing of MO-MSCs toward established 578T and MD-MBA-231 breast cancer and A375N melanoma tumor xenografts. Tumor penetration by MO-MSCs was highly dependent on metallopeptidases production as it was inhibited by the specific inhibitor 1,10 phenantroline. Finally, systemically administered MO-MSCs preloaded with an oncolytic adenovirus significantly inhibited tumor growth in mice harboring established A375N melanomas, overcoming the natural resistance of the tumor to in situ administration of the oncolytic adenovirus. In summary, this work characterizes a novel MSC subpopulation with increased tumor homing capacity that can be used to transport therapeutic compounds.","palabras_clave":"MESENCHIMAL STROMAL CELLS|MELANOMA|GENE THERAPY|CRADS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87826,"idioma_id":4,"titulo":"Ionic liquid aqueous solutions undernanoconfinement","resumen":"We extend our previous molecular dynamics analysis of confined aqueouselectrolytes within cylindrical hydrophobic pores of nanometric dimensions [Videla et al. J.Chem. Phys. 2011, 135, 104503] to the case of room temperature ionic liquid (RTIL)solutions, with concentrations close to c &#8764; 1 M. Equilibrium and dynamical characteristicsof two imidazolium-based RTILs, differing in the hydrophobicity of the correspondinganionic species, were considered. The solutions within the pore were modeled in contactwith \u201Cbulk-like\u201D reservoirs, which served as reference systems to gauge the magnitude of themodifications observed in the global densities and in the transport coefficients. The densityfields associated to the ionic species present a marked enhancement near the pore walls; thisleads to increments of the global RTIL concentration within the pores, which areintermediate between 2 and 3 times the ones observed in the bulk reservoirs. Thesemodifications are more marked in solutions containing more hydrophobic anionic species.In both cases, selective adsorption of imidazolium groups at the pore walls prevails; thesewall-solvation states are characterized by a parallel orientation of the imidazolium ring, with respect to the pore surface. Mass andcharge transport were also investigated. The segregation of the ionic species towards the pore wall promotes a sharp drop in theindividual ionic diffusion coefficients. Nonuniform trends in the modifications of the ionic conductivity were found. Our resultsshow that charge transport is the result of a complex interplay between competing effects involving modifications in the localconcentrations, retardations in the ionic mobility, and dynamical cross-correlations, as well. A physical interpretation of the lattereffects is provided in terms of the differences in the spatial correlations of the ionic species within the interior of the pore.","palabras_clave":"Confinement|Molecular Dynamics|Ionic Liquids"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87827,"idioma_id":5,"titulo":"Enfoque de derechos y prácticas profesionales: conocimiento de la legislación vigente y su utilización por profesionales de salud mental de la Ciudad de Buenos Aires","resumen":"El presente trabajo se enmarca en el proyecto ?Avances y desafíos en la construcción de un sistema de protección integral de los derechos de las niñas, niños y adolescentes: el derecho a la salud de la infancia en situación de vulnerabilidad social en ciudad de Buenos Aires? (Secretaria de Ciencia y Técnica de la UBA, programación Científica 2008-2010). Este proyecto estudió las características de las políticas públicas de infancia, en su articulación con el campo de la salud y con las respuestas institucionales estatales a la luz de la legitimidad cobrada por la noción de protección integral de derechos. En este encuadre, abordó el proceso de construcción del ?Sistema de protección integral de los derechos de las niñas, niños y adolescentes? en la Ciudad de Buenos Aires, impulsado por la Ley Nacional 26.061 sancionada en el año 2005. En el marco de la nueva legislación, las respuestas institucionales destinadas a la niñez se encuentran en un profundo proceso de reformulación que requiere ser analizado. Para profundizar en el conocimiento de este proceso -haciendo énfasis en el campo de la salud mental-, se establecieron para los profesionales que trabajan en los servicios de salud mental del subsector público?estatal de la Ciudad Autónoma de Buenos Aires (en adelante CABA) dimensiones que incluían el conocimiento y la valoración de los principios fundamentales de las leyes de Protección integral de los derechos de niños, niñas y adolescentes y Salud Mental,  y  su impacto en  las prácticas y en la organización de los servicios de salud.El análisis de los discursos de los actores respecto al marco jurídico legal existente en la CABA permitió comprender la participación de los mismos en la construcción de un campo configurado en torno de la distinción entre dos matrices discursivas respecto de la niñez: el discurso de la tutela y el de los derechos, situando las tensiones discursivas emergentes que luego se manifiestan en las prácticas profesionales que materializan o vulneran los derechos en cuestión","palabras_clave":"NIÑEZ|SALUD|DERECHOS|PRACTICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87828,"idioma_id":4,"titulo":"Collisions of Porous Clusters: : A Granular-mechanics Study of Compaction and Fragmentation","resumen":"The collision of granular clusters can result in a number of complex outcomes from sticking to partial or full destruction of the clusters. These outcomes will contribute to the size distribution of dust aggregates, changing their optical properties and their capability to contribute to solid-state astrochemistry. We study the collision of two clusters of equal size, formed by approximately 7000 sub-ìm grains each, with a mass and velocity range that is difficult to sample in experiments. We obtain the outcome of the collision: compaction, fragmentation, and size distribution of ejecta, and type of outcome, as a function of velocity and impact parameter. We compare our results to other models and simulations, at both atomistic and continuum scales, and find some agreement together with some discrepancies. We also study collision-induced compaction as a function of cluster size, up to sizes of N = 250, 000, and find that for large clusters considerably higher compactions result at higher velocities.","palabras_clave":"METHODS: STATISTICAL|PLANETS AND SATELLITES: FORMATION|PROTOPLANETARY DISKS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87829,"idioma_id":4,"titulo":"Identification of new microRNA-regulated genes by conserved targeting in plant species","resumen":"    MicroRNAs (miRNAs) are major regulators  of gene expression in multicellular organisms. They recognize their targets by  sequence complementarity and guide them to cleavage or translational arrest. It  is generally accepted that plant miRNAs have extensive complementarity to their  targets and their prediction usually relies on the use of empirical parameters  deduced from known miRNA?target interactions. Here, we developed a strategy to  identify miRNA targets which is mainly based on the conservation of the  potential regulation in different species. We applied the approach to expressed  sequence tags datasets from angiosperms. Using this strategy, we predicted many  new interactions and experimentally validated previously unknown miRNA targets  in Arabidopsis  thaliana. Newly  identified targets that are broadly conserved include auxin regulators,  transcription factors and transporters. Some of them might participate in the  same pathways as the targets known before, suggesting that some miRNAs might  control different aspects of a biological process. Furthermore, this approach  can be used to identify targets present in a specific group of species, and, as  a proof of principle, we analyzed Solanaceae specific targets. The presented strategy can be used  alone or in combination with other approaches to find miRNA targets in plants.  ","palabras_clave":"MicroRNA|TARGET|VALIDATION STRATEGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87830,"idioma_id":4,"titulo":"Flavodoxin displays dose-dependent positive and negative effects on photosynthesis and stress tolerance when expressed in transgenic tobacco plants","resumen":"Ferredoxins are-iron sulfur proteins involved in various one-electron transfer pathways. Ferredoxin levels decrease under adverse environmental conditions in photosynthetic organisms. In cyanobacteria, this decline is  compensated by induction of flavodoxin, an isofunctional  flavoprotein. Flavodoxin is not present in higher plants, but  transgenic Nicotiana tabacum lines accumulating Anabaena  flavodoxin in plastids display increased tolerance to  different sources of environmental stress. As the degree of  tolerance correlated with flavodoxin dosage in plastids of  nuclear transformed transgenic tobacco, we prepared  plants expressing even higher levels of flavodoxin by direct  plastid transformation. A suite of nuclear- and chloroplasttransformed  lines expressing a wide range of flavodoxin  levels, from 0.3 to 10.8 lmol m-2, did not exhibit any  detectable growth phenotype relative to the wild type. In  the absence of stress, the contents of both chlorophyll a and  carotenoids, as well as the photosynthetic performance  (photosystem II maximum efficiency, photosystem II  operating efficiency, electron transport rates and carbon  assimilation rates), displayed a moderate increase with  flavodoxin concentrations up to 1.3 - 2.6 lmol flavodoxin  m-2, and then declined to wild-type levels. Stress tolerance,  as estimated by the damage inflicted on exposure to  the pro-oxidant methyl viologen, also exhibited a bellshaped  response, with a significant, dose-dependent  increase in tolerance followed by a drop in the highexpressing  lines. The results indicate that optimal photosynthetic  performance and stress tolerance were observed  at flavodoxin levels comparable to those of endogenous  ferredoxin. Further increases in flavodoxin content become  detrimental to plant fitness.","palabras_clave":"Flavodoxin |Ferredoxin |Oxidative stress |Transplastomic transformation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87831,"idioma_id":4,"titulo":"The importance of flavodoxin for environmental stress tolerance in photosynthetic microorganisms and transgenic plants. Mechanism, evolution and biotechnological potential","resumen":"Ferredoxins are electron shuttles harboring iron-sulfur clusters which participate in oxidoreductive  pathways in organisms displaying very different lifestyles. Ferredoxin levels decline in plants  and cyanobacteria exposed to environmental stress and iron starvation. Flavodoxin is an isofunctional  flavoprotein present in cyanobacteria and algae (not plants) which is induced and replaces ferredoxin  under stress. Expression of a chloroplast-targeted flavodoxin in plants confers tolerance to multiple  stresses and iron deficit. We discuss herein the bases for functional equivalence between the two  proteins, the reasons for ferredoxin conservation despite its susceptibility to aerobic stress and for the  loss of flavodoxin as an adaptive trait in higher eukaryotes. We also propose a mechanism to explain  the tolerance conferred by flavodoxin when expressed in plants.","palabras_clave":"flavodoxin|ferredoxin|stress physiology|photosynthesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87832,"idioma_id":4,"titulo":"Crater formation by nanoparticle impact: contributions of gas, melt and plastic flow","resumen":"The processes underlying crater formation by energetic nanoparticle   impact are investigated using molecular dynamics simulations. Both   metallic and van-der-Waals-bonded targets are studied. We find a   transition from crater formation by melt flow at small impact energies   to an evaporation (gas flow) mechanism at higher energies. The   transition occurs gradually at impact energies per atom of a few tens of   the cohesive energy of the target. van-der-Waals-bonded solids do not   exhibit the melt flow cratering regime, in agreement with the narrow   liquid zone in their phase diagram. We find that the size of the target   region heated above the critical temperature roughly corresponds to the   crater volume. The transition shows up most clearly in the increase of   the volume of ejected material relative to the crater volume. Finally,   we demonstrate the punching of dislocations below the crater for   high-velocity impact into ductile targets, leading to a contribution of   plastic flow to the crater volume.","palabras_clave":"Condensed matter: electrical, magnetic and optical |Condensed matter: structural, mechanical & thermal |Nanoscale science and low-D systems |Astrophysics and astroparticles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87833,"idioma_id":4,"titulo":"Analytical solution of the mean field Ising model for finite systems","resumen":"The Ising model for finite systems, e.g.&nbsp;for clusters of different sizes and crystal lattices, was solved analytically by the mean field approach. The magnetization was calculated from the number of accessible microstates, using the gamma function and its derivatives, unlike the usual solution in the microcanonical which uses the Stirling approximation. We determined a scaling exponent of ~1\/3, which shows how the Curie temperature decreases with decreasing nanoparticle size. Moreover, the model predicts the behaviour of surface and core regions and it explains in simple terms several effects previously observed in experiments and Monte Carlo simulations of small magnetic systems.","palabras_clave":"small systems|clusters|ferromagnetism|Ising model"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87834,"idioma_id":4,"titulo":"Orbital symmetry reconstruction and strong mass renormalization in the two-dimensional electron gas at the surface of KTaO3","resumen":"We study, using angle-resolved photoemission spectroscopy, the two-dimensional electron gas (2DEG) at thesurface of KTaO3 (KTO), a wide-gap insulator with strong spin-orbit coupling (SOC).We find that this 2DEG isa genuinely different physical state with respect to the bulk: the orbital symmetries of its subbands are entirelyreconstructed and their masses are renormalized. This occurs because the values of the SOC, the Fermi energy,and the subband splittings become comparable in the 2DEG. Additionally, we identify an F-center-like heavyband resulting from the polar nature of the KTO surface.","palabras_clave":"gas 2D (2DEG)|KTaO3|ARPES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87835,"idioma_id":5,"titulo":"La implementación local de la Atención Primaria en la Argentina: Estudio de caso en el Municipio de Lanús, Provincia de Buenos Aires","resumen":"  Se presentan resultados en Argentina de la segunda etapa de un estudio multicéntrico sobre Atención Primaria de la Salud, realizado por la Universidad Nacional de Lanús\/Red de Investigación en Sistemas y Servicios de Salud del Cono Sur, financiado por el IDRC\/CIID (Canadá). Se indagó sobre  la traducción en servicios, prácticas y procesos de los abordajes y modelos de la APS. Es un estudio de caso que aplicó el cuestionario de Evaluación Rápida de APS (Barbara Starfield; adaptación y validación Almeida\/Macinko) a usuarios y profesionales de centros de salud del Municipio de Lanús. Se entrevistó a gestores y se realizaron talleres participativos. Los resultados señalan que el índice global de desempeño de la AP en el municipio fue satisfactorio, con puntuaciones altas en las dimensiones ?vínculo con profesionales? y ?formación profesional?, bajas en ?acceso? y ?orientación a la comunidad?       ","palabras_clave":"Atención primaria|Primer nivel de atención|Diagnóstico|Desempeño"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87836,"idioma_id":4,"titulo":"Inhibition of Connexin 43 in cardiac muscle during intense physical exercise","resumen":"              Endurance  training is accompanied by important adaptations in both cardiovascular and  autonómic nervous systems. Previous works have shown that the main component of  gap-junctions in the ventricular myocardium (connexin 43-Cx43) can be regulated  by adrenergic stimulus. On the other hand, training raises vagal and decreases sympathetic tone, while  augmenting myocardial sensitivity to sympathetic stimulation during exercise.  We therefore evaluated the regulation of Cx43 expression by sympathetic tone  during exercise in trained and sedentary mice. Training induced an increase in  the protein level of Cx43 by 45-70% under resting conditions. The expression of  Cx43 was inhibited in trained but not in untrained mice in response to a 60 min  exercise bout. Normal basal expression was restored after 60 min of resting.  Cx43 reached a minimum that was not different from basal expression in  untrained mice. In accordance, ECG and action potential analysis did not reveal  major electrophysiological implications for the drop in Cx43 abundance in  trained-exercise mice. We prevented Cx43 inhibition using propranolol, and  observed increased basal mRNA levels of &#946;-adrenergic receptors without  significant changes in the ratio &#946;1 to &#946;2. In conclusion,  we showed that Cx43 expression is transiently inhibited by &#946;-adrenergic  stimulus in trained mice during acute exercise. ","palabras_clave":"Sistema Nerviosos Simpatico|Uniones Gap|Natacion|Entrenamiento de Resistencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87837,"idioma_id":4,"titulo":"Modelling the effect of phosphorylation on the circadian clock of Drosophila","resumen":"It is by now well known that, at the molecular level, the core of the circadian clock of most living species is a negative feedback loop where some proteins inhibit their own transcription. However, it has recently been shown that post-translational processes, such as phosphorylations, are essential for a correct timing of the clock. Depending on which sites of a circadian protein are phosphorylated, different properties such as degradation, nuclear localization and repressing power can be altered. Furthermore, phosphorylation domains can be related in a positive way, giving rise to consecutive phosphorylations, or in a negative way, hindering phosphorylation at other domains. Here we present a simple mathematical model of a circadian protein having two mutually exclusive domains of phosphorylation. We show that the system has limit cycles that arise from a unique fixed point through a Hopf bifurcation. We find a set of parameters, with realistic values, for which the limit cycle has the same period as the wild type circadian oscillations of the fruit fly. The domains act as a switch, in the sense that alterations in their phosphorylation can alter the period of circadian oscillation in opposite ways, increasing or decreasing the period of the wild type oscillations. In particular, we show that our model is able to reproduce some of the experimental results found for switch-like phosphorylations of the PER protein of the circadian clock of the fly Drosophila melanogaster.","palabras_clave":"Complex systems|Dynamical systems; |Systems biology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87838,"idioma_id":4,"titulo":"Toxoplasma gondii infection induces suppression in a mouse model of allergic airway inflammation","resumen":"Allergic asthma is an inflammatory disorder characterized by infiltration of the airway wall with inflammatory cells drivenmostly by activation of Th2-lymphocytes, eosinophils and mast cells. There is a link between increased allergy anda reduction of some infections in Western countries. Epidemiological data also show that respiratory allergy is less frequentin people exposed to orofecal and foodborne microbes such as Toxoplasma gondii. We previously showed that both acuteand chronic parasite T. gondii infection substantially blocked development of airway inflammation in adult BALB\/c mice.Based on the high levels of IFN-c along with the reduction of Th2 phenotype, we hypothesized that the protective effectmight be related to the strong Th1 immune response elicited against the parasite. However, other mechanisms could alsobe implicated. The possibility that regulatory T cells inhibit allergic diseases has received growing support from both animaland human studies. Here we investigated the cellular mechanisms involved in T. gondii induced protection against allergy.Our results show for the first time that thoracic lymph node cells from mice sensitized during chronic T. gondii infectionhave suppressor activity. Suppression was detected both in vitro, on allergen specific T cell proliferation and in vivo, onallergic lung inflammation after adoptive transference from infected\/sensitized mice to previously sensitized animals. Thisability was found to be contact- independent and correlated with high levels of TGF-b and CD4+FoxP3+ cells.","palabras_clave":"ALERGIA|TOXOPLASMA GONDII|SUPRESION|INFLAMACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87839,"idioma_id":4,"titulo":"Therapy of chagas disease: implications for levels of prevention","resumen":"This paper reviews the evidence supporting the use of etiological treatment for Chagas disease that has changed the standard of care for patients with Trypanosoma cruzi infection in the last decades. Implications of this evidence on different levels of prevention as well as gaps in current knowledge are also discussed. In this regard, etiological treatment has shown to be beneficial as an intervention for secondary prevention to successfully cure the infection or to delay, reduce, or prevent the progression to disease, and as primary disease prevention by breaking the chain of transmission. Timely diagnosis during initial stages would allow for the prescription of appropriate therapies mainly in the primary health care system thus improving chances for a better quality of life. Based on current evidence, etiological treatment has to be considered as an essential public health strategy useful to reduce disease burden and to eliminate Chagas disease altogether.","palabras_clave":"EVIDENCE SUPPORTING  ETIOLOGICAL TREATMENT FOR CHAGAS|SECONDARY PREVENTION TO SUCCESFULLY  CURE|TREATMENT HAS TO BE CONSIDERED AN ESSENTIAL PUBLIC HEALTH STRATEGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87840,"idioma_id":5,"titulo":"Del objeto al símbolo: Aspectos cognitivos y sociales del conocimiento infantil sobre las imágenes","resumen":"Desde temprano en sus vidas, los niños están expuestos a una variedad de representaciones figurativas en fotografías, libros, en la televisión y el video. Este artículo postula que a pesar de la similitud perceptual entre estas imágenes y sus referentes, su comprensión es un proceso complejo en el que participan mecanismos perceptuales, cognitivos y socio-cognitivos. La primera parte del artículo revisa investigaciones que han identificado los principales hitos evolutivos en la comprensión de las representaciones figurativas y los mecanismos perceptuales y cognitivos que subyacen a este proceso. Este análisis permite proponer tres fases en este desarrollo (pre-simbólica, simbólica y post-simbólica) desde el nacimiento hasta el comienzo de los años escolares. La segunda parte examina la influencia en la comprensión de factores relacionados con el contexto social, específicamente la experiencia simbólica y la intención del creador y\/o el usuario de una imagen. De esta manera, las habilidades para la cognición social y el aprendizaje cultural son también cruciales en el conocimiento y uso de representaciones figurativas. PUBLICACIÓN INDEXADA EN: PsychologicalAbstracts, PsycINFO, PsycLit, SciELO, RedALyC, IP &amp; Science de ThomsonReuters, Latindex Catálogo, EBSCO, Scopus, Dialnet, DOAJ, BVS, PEPSIC, LILACS, PSERINFO,PSICODOC &nbsp;","palabras_clave":"REPRESENTACIONES FIGURATIVAS|COMPRENSIÓN|REPRESENTACIÓN DUAL|INTENCIONALIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87841,"idioma_id":5,"titulo":"¿La inflamación del testículo contribuye a la infertilidad? Datos experimentales y de la patología humana","resumen":"La inflamación y las infecciones del tracto genital masculino pueden ser causas frecuentes o co-factores de infertilidad. Aproximadamente el 15% de los pacientes con infertilidad poseen un componente inflamatorio que involucra la presencia de infiltrados intersticiales del testículo (orquitis) o del testículo y epidídimo (orqui-epididimitis) generalmente asociados a un daño de los túbulos seminíferos. Los modelos experimentales de orquitis autoinmune (OAE) han contribuido a dilucidar los mecanismos patogénicos de la inflamación testicular. En el intersticio testicular de la rata con OAE hemos detectado un aumento en el número de macrófagos, células dendríticas y linfocitos T efectores con perfil Th1 y Th17. Las citocinas proinflamatorias producidas por dichas células alteran el microambiente inmunosupresor normal del testículo y esto se asocia a un daño de las células germinales que sufren apoptosis y descamación. Los linfocitos T regulatorios también aumentan numéricamente, aunque no logran contrarrestar la inflamación. Recientemente, se describió en biopsias testiculares de pacientes subfértiles e infértiles un aumento en el número de linfocitos T, macrófagos y mastocitos y en la expresión de IL-17, IL-21 e IL-22 en el testículo de pacientes con inflamación crónica. La comprensión de las interacciones entre células germinales y del sistema inmune facilitará la búsqueda de parámetros útiles para el diagnóstico, pronóstico y tratamiento de los procesos inflamatorios testiculares crónicos asociados a subfertilidad e infertilidad.","palabras_clave":"TESTICULO|INFLAMACION|ORQUITIS AUTOINMUNE|INFERTILIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87842,"idioma_id":4,"titulo":"Polycrystalline iron under compression: Plasticity and phase transitions","resumen":"Iron undergoes a bcc to close-packed structural phase transition under   pressure, at around 13 GPa, as shown by diamond anvil and shock   experiments. Atomistic simulations have been able to provide insights   into the transition, but without any plasticity occurring before the   phase change, in single crystals, defective single crystals, or   polycrystals. However, experiments in polycrystals do show clear   evidence for plasticity. Here we study homogeneous uniaxial compression   of polycrystalline Fe using several interatomic potentials: three   embedded-atom-model potentials and one modified embedded-atom-model   potential. We analyze grain-boundary rotation and dislocation activity,   and find that the amount of dislocation activity as a function of strain   depends greatly on the potential used. This variation can be explained   in terms of the dislocation properties, calculated in this work for each   of these potentials.","palabras_clave":"62 . 20 . F &#8722;|61 . 72 . Lk|61 . 50 . Ks|64 . 70 . Nd"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87843,"idioma_id":5,"titulo":"La calidad del agua del río Luján (Buenos Aires) y el potencial aporte del biofilm para su evaluación","resumen":"Luján River rises in the north-eastern part of Buenos Aires Province and flows through a lowland region where it joins the River Plate Estuary. The rivers upper basin comprises a rural area which is mainly used for extensive agriculture and livestock with industrial areas of minor influence. As moving downstream, densely populated urban regions develop and industrial activity increases. Samples were collected seasonally from August 2004 to August 2005 in 12 sampling sites located along the river basin, from its headwater tributaries (Los Leones y El Durazno streams) to the crossing of the national route 9, located in the rivers lower basin. In two out of the four sampling occassions, biofilm samples were taken with the aim of assesing to what extent the biofilm community fitted the degradation level indicated by the measured physical-chemical variables of the river water (particularly BOD; N; P and DO concentrations). The samples were taken with a 3 cm2 brush and piston from submerged surfaces of natural (tosca) or artificial substrates (piers; walls). Bacillariophyta generally dominates the biofilm, but there seems to be a relationship between the industrial and urban sewage discharges, the water quality and the relative abundance of the different biofilm groups. In the river reaches where a heavy load of effluents is discharged, an increment of Cyanophyceae is observed. In the reaches of intermediate degradation, associations of cyanophytes and euglenoids appear. Over the course of the river, the algae abundance diminishes along with the water quality degradation, but there are also reaches of recovery due to the river?s own processing capacity where no urban nor industrial wastewaters are discharged.","palabras_clave":"RIO LUJAN|BIOFILM|CALIDAD DEL AGUA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87844,"idioma_id":4,"titulo":"*. A Unique Ionic Liquid with Amphiphilic Properties That Can Form Reverse Micelles and Spontaneous Unilamellar Vesicles","resumen":"Reversed micelles (RMs) are spatially ordered macromolecular assembly of surfactants formed in a nonpolar solvent, in which the polar head groups of the surfactants point inward and the hydrocarbon chains point toward the nonpolar medium.","palabras_clave":"líquidos iónicos|micelas|vesículas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87845,"idioma_id":4,"titulo":"Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on sertoli cell tight junctions","resumen":"Inflammation of the male reproductive tract is accepted asbeing an important etiological factor of infertility. Experimentalautoimmune orchitis (EAO) is characterized by interstitiallymphomononuclear cell infiltration and severe damage ofseminiferous tubules with germ cells that undergo apoptosisand sloughing. Because the blood-testis barrier (BTB) is relevantfor the protection of haploid germ cells against immune attack,the aim of this study was to analyze BTB permeability and theexpression of tight junction proteins (occludin, claudin 11, andtight junction protein 1 [TJP1]) in rats during development ofautoimmune orchitis. The role of IL6 as modulator of tightjunction dynamics was also evaluated because intratesticularcontent of this cytokine is increased in EAO rats. Orchitis wasinduced in Sprague-Dawley adult rats by active immunizationwith testicular homogenate and adjuvants. Control rats (C) wereinjected with saline solution and adjuvants. Untreated (N) ratswere also studied. Concomitant with early signs of germ cellsloughing, a reduced expression of occludin and delocalizationof claudin 11 and TJP1 were detected in the testes of rats withEAO compared to C and N groups. The use of tracers showedincreased BTB permeability in EAO rats. Intratesticular injectionof IL6 induced focal testicular inflammation, which is associatedwith damaged seminiferous tubules. Rat Sertoli cells cultured inthe presence of IL6 exhibited a redistribution of tight junctionproteins and reduced transepithelial electrical resistance. Thesedata indicate the possibility that IL6 might be involved in thedownregulation of occludin expression and in the modulation ofBTB permeability that occur in rats undergoing autoimmuneorchitis","palabras_clave":"TIGHT JUNCTION PROTEINS|BLOOD TESTIS BARRIER|IL-6|AUTOIMMUNE ORCHITIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87846,"idioma_id":4,"titulo":"A Perspective of End-of-life Care Education in Undergraduate Medical and Nursing Students in Buenos Aires, Argentina","resumen":"Background: The goals of this study were to evaluate: #1# the experiences and attitudes after exposure to dyingpatients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^patients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^The goals of this study were to evaluate: #1# the experiences and attitudes after exposure to dyingpatients in undergraduate medicine and nursing students with lack of training in end-of-life care issues; #2#whether or not exposure to terminally ill patients #TIPs# influences attitudes in students who had no training inend-of-life care; #3# students wishes regarding their future care of TIPs; and #4# if medicine and nursing studentsare indeed interested in receiving training in end-of-life care^Materials and methods: A survey was administered to students in the first and last year in schools of medicineand nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^and nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^A survey was administered to students in the first and last year in schools of medicineand nursing, comprising seven universities in the city of Buenos Aires, Argentina, and surrounding areas^ Datawere collected during the 2005 to 2010 time period^ Data from 730 students were analyzed^Discussion and conclusion: We found that nursing and medical undergraduate students at nursing and medicineschools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^schools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it^ For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue^We found that nursing and medical undergraduate students at nursing and medicineschools in the city of Buenos Aires and surrounding areas: #a# come in direct contact with TIPs and perceivetheir suffering; and #b# have a highly positive attitude toward these patients, even though some of them referredto that relationship as arduous and in some cases they tended to avoid emotional involvement because they didnot feel well trained^ We also found that #c# this wish for avoidance was increased in final-year medical andnursing students who had been exposed to a higher number of TIPs; and #d# students unanimously manifestedthe opinion that the teaching about caring of TIPs should be included in the curricula and they would be welldisposed to receive it. For all these reasons, we consider that the teaching of caregiving to TIPs in the academicdegree programs of nursing and medicine should not be presented as a marginal issue.","palabras_clave":"Cuidados Paliativos|Educación médica enfermeria de grado|Cuidados de Final de Vida|Muerte"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87847,"idioma_id":4,"titulo":"Biodegradation of hydrocarbons and cultivable bacterial diversity in Rada Tilly coast line, Patagonia, Argentina","resumen":"Rada Tilly city is located between Comodoro Rivadavia and Caleta Olivia cities. Both cities have oil industry activity and oil tankers sail in front of the beach on their way to the loading buoy. The aim of the work was to study the bacterial communities and their capacity to use hydrocarbons. We took samples from three different points in every season of the year, both sediment and seawater samples. Oligotrophic and hydrocarbon degrading bacteria counts were done, and the mineralization of diesel, kerosene, gasoline, oil and lubricant oil were carried out during 50 days. Bacterial communities were grown for 10 days on oligotrophic liquid media and media containing phenanthrene and hexadecane as contaminants and analyzed by methyl fatty acids (FAMEs) profiling. In addition, bacterial isolates obtained were identified by FAMEs. The results showed that the cultivable bacterial communities were similar in spring, summer and autumn and this was made up of Pseudoalteromonas, Rhodobacter, Aeromonas, Ochrobactrum, Photobacterium, Brevundimonas and Vibrio. In winter season, the bacterial communities changed and were made up of Micrococcus, Staphylococcus, Bacillus, Arthrobacter and Paenibacillus. The hydrocarbon mineralization was higher in sediment samples than in seawater samples. The best results were observed in summer. The best values were obtained from oil, diesel oil, kerosene and lubricant oil.","palabras_clave":"HYDROCARBONS|BIODEGRADATION|SEAWATER|MARINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87848,"idioma_id":5,"titulo":"Seguridad para todos: territorios y policiamientos","resumen":"Gendarmería y Prefectura cambiaron sus funciones y territorios de operación en los últimos años, modificando la relación entre ciudadanos y fuerzas de seguridad, y compartiendo espacio con policías provinciales y Federal. Los desafíos de un proceso inédito en nuestro país.En nuestro país, en esta última década, las fuerzas policiales y de seguridad han sobrellevado diferentes transformaciones ?cambio de tareas, de espacios geográficos, creación de nuevas fuerzas? que implicaron desplazamientos y superposición de quehaceres. Nos interesa describir y reflexionar acerca de los alcances de estos cambios y preguntarnos específicamente acerca de las nuevas configuraciones espaciales en las cuales intervienen las fuerzas de seguridad.","palabras_clave":"POLICIAS|SEGURIDAD|TERRITORIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87850,"idioma_id":4,"titulo":"Anthropology and Childhood. From Research Teams to the Development of Teaching and Learning Spaces in the Buenos Aires Area (Argentina)","resumen":"In the last few decades in Argentina, childhood began to emerge as a legitimate field of anthropological research. Constant work by local researchers and the growth of research teams have given rise to educational activities in this field at universities all over the country. The focus of analysis in this paper are the different courses developed as part of undergraduate and graduate training programs in Anthropology at four public universities in the city and province of Buenos Aires. The study of the seminar\u2019s syllabuses shows, on the one hand, plenty and varied subject matters concerning childhood both directly and indirectly. On the other hand, we will examine the shared stress of such courses on the potential of anthropology to deconstruct childhood through historical and ethnographical approaches.","palabras_clave":"ANTHROPOLOGY AND CHILDHOOD|HIGHER EDUCATION|BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87851,"idioma_id":4,"titulo":"Unexpected skeletal histology of an ichthyosaur from the Middle Jurassic of Patagonia: implications for evolution of bone microstructure among secondary aquatic tetrapods","resumen":"During the Mesozoic, one of the most significant evolutionary processes was the secondary adaptation of tetrapods to life in water. Several non-related lineages invaded from terrestrial realms the oceans of the entire world. Among these lineages, ichthyosaurs were particularly successful. Advance parvipelvian ichthyosaurs were the first tetrapods to evolve a fish-shaped body profile. The deep skeletal modifications of their bodies, as well as their biology, depict advance ichthyosaurs as the paradigm of secondary adaptation of reptiles to marine life. Functional inferences point to them as off-shore cruising forms, similar to living tuna, and some of them were capable of deep diving. Bone histology of some genera such as Temnodontosaurus, Stenopterygius, Ichthyosaurus and Caypullisaurus, characterized by overall cancellous bone, is consistent with the idea of fish-shaped ichthyosaurs as fast and far cruisers. Here we provide histological examination of the ribs of the Middle Jurassic parvipelvian Mollesaurus. Contrasting with the bone histology of other parvipelvian, Mollesaurus ribs are characterized by a compact and thick cortex. Our data indicate that the rib cage was heavy and suggest that not all advanced ichthyosaurs were fast cruisers. The compact and dense ribs in these parvipelvian, shows that advance ichthyosaurs were ecologically more diverse than previously thought, and that the lightening of the skeleton reversed, as also occurred in the evolution of cetacean, at least once along the evolutionary history of ichthyosaurs. ","palabras_clave":"Ichthyosaurs|Mollesaurus|Middle Jurassic|Bone Histology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87852,"idioma_id":4,"titulo":"Protein palmitoylation inhibition by 2-bromopalmitate alters gliding, host cell invasion and parasite morphology in Toxoplasma gondii","resumen":"Protein palmitoylation is the reversible covalent attachment of palmitic acid onto proteins. This post-translational modification has been shown to play a part in diverse processes such as signal transduction, cellular localization and regulation of protein activity. Although many aspects of protein palmitoylation have been identified in mammalian and yeast cells, little is known of this modification in Toxoplasma gondii. In order to determine the functional role of protein palmitoylation in T. gondii, tachyzoites were treated with the palmitoylation inhibitor 2-bromopalmitate (2-BP). Parasites treated with 2-BP displayed a significant increase in non-circular trails which were longer than those trails left by non-treated parasites. Furthermore, 2-BP treatment reduced the invasion process to the host cells. Long-term treatment of intracellular tachyzoites resulted in major changes in parasite morphology and shape in a dose-dependent manner. These results suggest that palmitoylation could be modifying proteins that are key players in gliding, invasion and cytoskeletal proteins in T. gondii.","palabras_clave":"TOXOPLASMA|PALMITOYLATION|2-BROMOPALMITATE|INVASION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87853,"idioma_id":4,"titulo":"Protein Palmitoy l at ion a nd Pathogenesis in Apicomplexan Par asite s","resumen":"Apicomplexan parasites compr ise a broad variety of protozoan parasites, including. Toxoplasma gondii, Plasmodium, Eimeria, and  Cryptosporidium species. Being intracellular parasites, the success in establishing pathogenesis re lies in their abilit y to infect a host-ce ll and replicate w ithin it. Protein palmitoy lation is know n to affect m any asects of cell biology. Furthermore, palmitoylation has recently been shown to a ffect important processes in T. gondii such as replication, invasion, and gliding . Thus, this paper focuses  on the importance of protein palmitoylation in the pathogenesis of apicomplexan parasites","palabras_clave":"PALMITOYLATION|APICOMPLEXA|INVASION |GLIDING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87854,"idioma_id":5,"titulo":"Un estudio sobre la distribución regional de los préstamos en la Argentina por sector económico, 2000-2010. Una aplicación del análisis de cluster","resumen":"Analizaremos en este trabajo el tipo de actividades financiadas por los préstamos en la Argentina en el período 2000-2010. Estudiaremos además como fue la distribución de los préstamos en el país y en las provincias de acuerdo al sector productivo que financiaron, así también determinar si hay diferencias significativas entre las provincias en esta distribución. Para eso, utilizaremos la metodología de análisis de clúster de acuerdo al Método de Ward.  Como resultado de nuestra investigación, encontramos que existen considerables diferencias entre las distintas provincias en los rubros a los que se dirigen sus préstamos. Se puede observar además un fenómeno que podemos denominar la falta de un \u201CFederalismo Financiero\u201D, la elevada concentración del crédito en la Ciudad de Buenos Aires, lo que puede ser un factor que altere la posibilidad de aplicar políticas públicas de desarrollo a la actividad productiva. El elevado porcentaje de créditos otorgados a personas físicas explica que gran parte del crédito bancario tiene como destinatario fomentar el consumo, en perjuicio de la actividad productiva. Además esto puede explicarse por el escaso desarrollo de la banca privada en el interior del país, especialmente en las provincias que no tienen altos niveles de desarrollo o escasa población. La excepción a este es en algunas provincias con economías regionales desarrolladas como lo pueden ser Córdoba y Santa Fe, en las cuales se observa claramente como se canaliza el crédito de las entidades locales.","palabras_clave":"Estadistica|Economía Regional"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87855,"idioma_id":5,"titulo":"Dificultades lectoras en contextos de pobreza: ¿un caso de Efecto Mateo?","resumen":"El estudio exploró si las dificultades lectoras en contextos de pobreza pueden interpretarse en términos del Efecto Mateo, que postula una acumulación de las diferencias entre quienes ingresan a la escuela con altos y bajos conocimientos prelectores, como consecuencia de la interacción entre el perfil cognitivo de los niños y la intervención pedagógica. En base a las habilidades prelectoras (sensibilidad fonológica y correspondencias), entre 59 ingresantes a 1er año se identificó a niños en riesgo y sin riesgo. Se compararon sus habilidades de lectura y escritura durante tres años. En el primer año la distancia entre grupos se amplió, confirmando las predicciones del Efecto Mateo. A partir del segundo año la escuela proporcionó a los niños en riesgo un apoyo educativo adicional. La comparación posterior mostró que las diferencias entre grupos se fueron reduciendo (precisión y velocidad lectora, escritura fonológica) o se mantuvieron (escritura ortográfica) pero no se ampliaron.","palabras_clave":"Efecto Mateo en lectura|Niños en contextos de pobreza|Dificultades lectoras"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87856,"idioma_id":4,"titulo":"Electrobioremediation of Patagonian Soils Contaminated with Hydrocarbons","resumen":"The electrokinetic technique is used to remediate hydrocarbon-contaminated soil. The aim of this paper is to evaluate the feasibility of using this technology to remediate oilcontaminated soils in the Gulf of San Jorge. The soils used in this experiment were unsaturated soils contaminated by oil field operations being carried out in the area and previously remediated by landfarming. A potential difference of 0.5V cm-1 was applied to the electroremediation cells for 120 days; bridges of phosphate salt were used for the cells. Total hydrocarbons decreased from 4.22% to 3%, modifying the percentages of aliphatic, aromatic and polar hydrocarbons. The pH changed from 7.96 to 8.6 and 7.1 in the cathode and anode, respectively. The final pH values were compatible with the degrading bacterial community, whose colony-forming numbers did not present any alteration. On the cathode, there was an increase in the percentage of Gram-positive bacteria. Most of the species isolated were identified as Microbacterium luteus.","palabras_clave":"ELECTROKINECTIC|TPH|BACTERIA|UNSATURATED"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87857,"idioma_id":5,"titulo":"Análisis de Eficiencia de Algoritmos. Simulación como Recurso de Enseñanza-Aprendizaje","resumen":"La resolución de un problema usando una computadora puede ser modelada por diferentes algoritmos. De aquí la importancia de contar con herramientas que nos permitan seleccionar el algoritmo que sea más eficiente, es decir, el que insuma menos recursos del ordenador: tiempo y memoria necesarios para su ejecución. Existen dos formas de medir la complejidad de un algoritmo: análisis teórico y análisis empírico.En este trabajo se presenta la descripción del simulador, ?SIMULA-ALGO?, junto con la propuesta de uso y detalles del diseño de la interfaz. Se presenta además una fundamentación teórica sobre las ventajas del uso de la simulación como recurso pedagógico-didáctico.El simulador se propone como recurso para la enseñanza aprendizaje del análisis teórico de eficiencia de algoritmos. El mismo está destinado a alumnos de los primeros años de carreras universitarias de licenciatura en sistemas. Los contenidos considerados en el simulador, requieren, para su comprensión, del uso de procesos cognitivos analíticos. El simulador pretende optimizar estos procesos en el alumno que lo usa. Así, por ejemplo, el simulador podrá realizar procesos rutinarios en forma rápida y efectiva, permitiendo que el alumno se concentre en los procesos analíticos que requiere la tarea.","palabras_clave":"SIMULACIÓN|ALGORITMOS|ENSEÑANZA|UNIVERSIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87858,"idioma_id":4,"titulo":"Distribution, dispersal and spread of the invasive social wasp (Vespula germanica) in Argentina.","resumen":"We studied the distribution and spread of the invasive social wasp Vespula germanica in Argentina, focusing on the contribution of queen dispersal to territorial expansion. Vespula germanica is native to Eurasia and has invaded several regions of the world, including Southern Argentina. Flight potential of field-collected queens was measured using flight mills. Also, by means of an extensive survey we estimated the rate of spread by analysing the relationship between years since arrival and distance from the introduction locality. The mean distance flown by wasp queens in flight mills was 404.7  140.8 m (mean  SE, n = 59), while the rate of spread of V. germanica was estimated at 37.2  2.1 km year-1 (mean  SE, n = 67), although faster towards the south. The observedspread rate of V. germanica wasps in Argentina confirms the invasive potential shown by several Hymenoptera species worldwide. Still, a stratified geographical expansion pattern does not match observed queen dispersal abilities, suggesting that human-aided transport of hibernating queens is the central driver of the current distribution of these wasps.We suggest that despite several life-history traits known for social insects that contribute to successful invasion, wasp spread must still rely strongly on human mediated pathways.This observation sheds lighton those factors that are crucial for managing invasions of this and related pestiferous wasps.","palabras_clave":"flight mill|German wasps|insect invasion|yellowjackets"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87859,"idioma_id":4,"titulo":"Ecology of the woodwasp Sirex noctilio: Tackling the challenge of successful pest management.","resumen":"The invasive woodwasp Sirex noctilio has become one of the most significant pests of pine forests throughout the northern and southern hemispheres. In Patagonia (southern Argentina), S. noctilio was first detected in the early 1990s. However, in less than two decades, and despite intensive control efforts, populations have spread, and outbreaks have been observed. In this paper, we outline and define several key ecological and behavioral features of S. noctilio (namely, spatiotemporal population dynamics, phenology and dispersal) and briefly discuss their implications for the design, implementation and evaluation of local and regional management strategies. We argue that limited information on pest ecology and the extrapolation of control measures without local adaptation may together have affected management success. We conclude that efforts directed to understanding of pest ecology and life-history traits as expressed in specific invaded habitats may help us improve our competence in controlling invasive forest insects.Sirex noctilio has become one of the most significant pests of pine forests throughout the northern and southern hemispheres. In Patagonia (southern Argentina), S. noctilio was first detected in the early 1990s. However, in less than two decades, and despite intensive control efforts, populations have spread, and outbreaks have been observed. In this paper, we outline and define several key ecological and behavioral features of S. noctilio (namely, spatiotemporal population dynamics, phenology and dispersal) and briefly discuss their implications for the design, implementation and evaluation of local and regional management strategies. We argue that limited information on pest ecology and the extrapolation of control measures without local adaptation may together have affected management success. We conclude that efforts directed to understanding of pest ecology and life-history traits as expressed in specific invaded habitats may help us improve our competence in controlling invasive forest insects.","palabras_clave":"Forest pest|Integrated pest management|woodwasps|invasive insects"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87860,"idioma_id":4,"titulo":"Forest pest management: A global challenge","resumen":"No se incluye.","palabras_clave":"Forest insects"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87861,"idioma_id":6,"titulo":"La recherche qualitative en Argentine : des acquis et des questionnements.","resumen":"Les contributions, en exposant des problèmes liés à l\u2019interprétation, l\u2019analyse de données, la réflexivité dont on propose plusieurs conceptions. On fait attention ainsi à la manière dont ces questions vitales sont liées, d\u2019une part, avec la qualité de la recherche, et de l\u2019autre, avec les présupposés épistémologiques des chercheurs. Ces problèmes sont l\u2019axe principal sur lequel tournent les apports des chercheurs, résultant de leurs propres trajectoires de travail. C\u2019est pour cela que nous présenterons ici la portée, les particularités, la profondeur de ces problèmes, et leur traduction en forme d\u2019obstacles pendant le déroulement de la recherche. Après, nous n\u2019essaierons pas de résumer les contributions dans ce numéro, mais plutôt de mettre en évidence la signification de la nature des problèmes abordés, et en même temps, l\u2019hétérogénéité et la richesse des solutions et propositions trouvées par les auteurs pour les surmonter, collaborant ainsi avec la consolidation, le perfectionnement et l\u2019expansion de la recherche qualitative, caractérisée par la flexibilité dans sa conception et développement et par la rigueur dans chacune des étapes de la mise en place.","palabras_clave":"recherche qualitative|interpretation|analyse des données"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87862,"idioma_id":4,"titulo":"Structure of the Southern Patagonian Andes at 49ºS, Argentina","resumen":"This paper describes Late Paleozoic Gondwanan and Late Cretaceous to Early Cenozoic Andean structures in   the Southern Patagonian Andes and an associated Extra-Andean region between lakes San Martín and Viedma.   The study area encompasses a 200-km-long W-E section between the Patagonian icefield and the 72ºW longitude   meridian, in Argentine Patagonia. The oldest structures are of Late Paleozoic age and developed through at least   two deformation phases during the Gondwanan Orogeny. The first deformation phase (Dg1) includes isoclinal   and N-overturned WNW trending folds and associated thrusts, including duplexes. The second deformation   phase includes NNE trending open folds (Dg2). Deformation occurred in non-metamorphic to very low-grade   metamorphic conditions. A spaced rough cleavage is found near the first phase fold hinges. The Eocene and   Miocene Andean structural compression resulted in a N-S oriented fold and thrust belt. This belt is comprised of   three morphostructural zones from W to E, with distinctive topographic altitudes and structural styles: Andean;   Sub-Andean; and Extra-Andean zones. The first corresponds to the inner fold and thrust belt, while the last two   are part of the outer fold and thrust belt. The Andean zone (3400\u20132000m above sea level) is characterized by N-S   to NNE trending, E-vergent, Cenozoic reverse faults and associated minor thrusts. The northern part of the Sub-  Andean zone (2000\u20131500m above sea level) consists of W-vergent reverse faults and some NNE open folds. The   southern part of the Andean zone includes tight folds with box and kink geometries, related to thrusts at deeper   levels. In the Extra-Andean zone, with maximum heights of 1500m, the deformation is less intense, and gentle   folds deform the Upper Cretaceous sediments. An inherited Jurassic N-S extensional fault system imposed a   strong control on this morphostructural zonation. Also the variation of the Austral Basin sedimentary thickness in   the N-S direction seems to have influenced the structural styles of the outer fold and thrust belt. Those differences   in sedimentary thickness may be related to S-dipping transfer zones associated to W-E Jurassic extension. In turn,   the transfer zones may have been controlled by the N-vergent WNW, Dg1, Gondwanan structural fabric.","palabras_clave":"Andes Australes Patagónicos|Tectónica|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87863,"idioma_id":4,"titulo":"A Tumor-stroma Targeted Oncolytic Adenovirus Replicated in Human Ovary Cancer Samples and Inhibited Growth of Disseminated Solid Tumors in Mice","resumen":"Targeting the tumor stroma in addition to the malignant cell compartment is of paramount importance to achieve complete tumor regression. In this work, we modified a previously designed tumor stroma-targeted conditionally replicative adenovirus (CRAd) based on the SPARC promoter by introducing a mutated E1A unable to bind pRB and pseudotyped with a chimeric Ad5\/3 fiber (Ad F512v1), and assessed its replication\/lytic capacity in ovary cancer in vitro and in vivo. AdF512v1 was able to replicate in fresh samples obtained from patients: (i) with primary human ovary cancer; (ii) that underwent neoadjuvant treatment; (iii) with metastatic disease. In addition, we show that four intraperitoneal (i.p.) injections of 5 × 1010 v.p. eliminated 50% of xenografted human ovary tumors disseminated in nude mice. Moreover, AdF512v1 replication in tumor models was enhanced 15-40-fold when the tumor contained a mix of malignant and SPARC-expressing stromal cells (fibroblasts and endothelial cells). Contrary to the wild-type virus, AdF512v1 was unable to replicate in normal human ovary samples while the wild-type virus can replicate. This study provides evidence on the lytic capacity of this CRAd and highlights the importance of targeting the stromal tissue in addition to the malignant cell compartment to achieve tumor regre","palabras_clave":"Gene Therapy|Ovary Cancer|CRAd"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87864,"idioma_id":4,"titulo":"Studying playoff qualification in motorsports via mixed-integer programming techniques","resumen":"The present authors consider the widely popular Argentine Turismo Carretera car racing series, which consists of 11 regular phase races followed by five playoff races. After the regular phase, the first 12 racers in the standings qualify for the playoffs, which determine the champion. The present authors address the problem of determining, at any point within the regular phase, the minimum number of points that each racer must earn in the remainder of the regular phase in order to secure a playoff spot. Two mixed-integer programming models for this problem are presented, their properties and practical performance are analysed, and the obtained results are discussed.","palabras_clave":"mixed-integer programming|playoff qualification|motorsports"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87865,"idioma_id":4,"titulo":"Magnetism and electrode dependant resistive switching in Ca doped ceramic bismuth ferrite","resumen":"Here we report on the preparation and structural, magnetic and electrical characterization of BiFeO3 and Bi0.9Ca0.1FeO3 ceramic multiferroic samples. We suggest that Ca-doping creates oxygen vacancies and destabilizes the BiFeO3 spiral magnetic structure. We also study resistive switching effects in Bi0.9Ca0.1FeO3 with metallic electrodes, finding that the appearance of the effect is dependant on the fabrication procedure of the metallic electrode. On the basis of these observations, we critically revise some assumptions in currently available models of resistive switching of complex oxides. 3 and Bi0.9Ca0.1FeO3 ceramic multiferroic samples. We suggest that Ca-doping creates oxygen vacancies and destabilizes the BiFeO3 spiral magnetic structure. We also study resistive switching effects in Bi0.9Ca0.1FeO3 with metallic electrodes, finding that the appearance of the effect is dependant on the fabrication procedure of the metallic electrode. On the basis of these observations, we critically revise some assumptions in currently available models of resistive switching of complex oxides. © 2012 Elsevier B.V. All rights reserved.","palabras_clave":"BIFEO3|MULTIFERROICS|RESISTIVE SWITCHING|RRAM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87866,"idioma_id":4,"titulo":"Optimization of resistive switching performance of metal-manganite oxide interfaces by a multipulse                    protocol","resumen":"We explore different resistance states of La0:325Pr0:300Ca0:375MnO3  Ti interfaces as prototypes of  non-volatile memory devices at room temperature. In addition to high and low resistance states  accessible through bipolar pulsing with one pulse, higher resistance states can be obtained by  repeatedly pulsing with a single polarity. The accumulative action of successive pulsing drives the  resistance towards saturation, the time constant being a strong function of the pulsing amplitude.  The experiments reveal that the pulsing amplitude and the number of applied pulses necessary to  reach a target high resistance value appear to be in an exponential relationship, with a rate that  results independent of the resistance value. Model simulations confirm these results and provide the  oxygen vacancy profiles associated to the high resistance states obtained in the experiments.","palabras_clave":"resistive switching|non volatile memories|manganites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87867,"idioma_id":5,"titulo":"Estrategias inclusivas en nuevos escenarios: El sujeto de derecho a través de su particularidad y la inserción en la economía social","resumen":"Esta propuesta está  destinada a acercar la producción de conocimientos de la Universidad Nacional de San Luís a la comunidad a través de la extensión con un enfoque de trabajo multidisciplinar. Para ello se convocaron estudiantes y docentes de diferentes carreras; ya que el contexto provincial (en paralelo al escenario nacional) esta demandando una reformulación de contenidos y conceptos con estrategias inclusivas desde la economía social como espacio de intervención, asimismo nos proponemos realizar una reflexión en torno a la relación  de la formación epistemológica, intentando producir movimientos de transformaciones de las representaciones sociales, a través de un trabajo holístico, posados en el paradigma de los Derechos Humanos orientando la capacidad para reconocer las necesidades sociales y fundamentalmente ser un sujeto congnoscente de los derechos vulnerados. Este escenario tiene como principal protagonista a los sujetos de intervención, que se han comprometido con una multiplicidad de actividades que tienen como objetivo general ser reconocidos en su particularidad. Se intenta resolver situaciones contradictorias a partir del requerimiento de  distintos colectivos, es allí que nos propusimos fortalecer la orientación, capacitación y reformulación de estrategias de estos actores sociales de manera conjunta. A partir de un  diagnostico realizado se observó sectores de la población que intentan organizarse \u201Cen defensa de sus derechos\u201D o bien para \u201Cgenerar bienes y servicios en la economía  social\u201D; éstos se conforman con sujetos expulsados o desafiliados del sistema que requieren nuevas formas de organización, reconociendo  sus propios saberes, experiencias  y habilidades en el abordaje del objeto de intervención; si bien,  algunos presentan  problemáticas comunes,  requieren de una participación en donde el factor interdisciplinario de los integrantes del equipo facilitará espacios  de intercambio significativo y nuevos aprendizajes  que redundarán en beneficios de sus prácticas sociales.","palabras_clave":"INCLUSIÓN|DERECHOS|DESAFILIACIÓN|PARTICULARIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87868,"idioma_id":4,"titulo":"Influence of silver concentrations on structural and magnetic properties of Ag-Fe3O4 heterodimer nanoparticles","resumen":"In the present work, we have reported the effect of Ag NPs seeds on the growth and magnetic properties of Ag-Fe3O4 heterodimer nanoparticles prepared using a two step chemical approach. Three different Ag NPs concentrations have been tried and thoroughly characterized using small angle x-ray scattering (SAXS), transmission electron microscopy (TEM), x-ray diffraction (XRD), dc magnetization, and x-ray absorption near edge spectroscopy (XANES). It is observed that at low concentration, the 'flower' types of nanoparticles are more favorable whereas the higher concentration of Ag NPs seeds promotes the growth of dimer type of structures. Our dc magnetization results are well correlated to the structural ones. The sample with lower amount of starting Ag NPs seeds possesses highest blocking and irreversibility temperature. On the other hand, the sample with highest concentration of Ag NPs seeds, the blocking temperature is lowered.","palabras_clave":"Magnetic Nanoparticles|Magnetite|Hyperthermia|Nanomagnetism|Nanotecnology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87869,"idioma_id":4,"titulo":"Magnetic Hydrophobic Nanocomposites: Silica Aerogel\/Maghemite","resumen":"Magnetic Hydrophobic Aerogels (MHA) as nanocomposites of silica and maghemite were prepared by one step sol-gel procedure followed by supercritical solvent extraction. Silica alcogels were obtained from TEOS, MTMS, Methanol and H2O, and Fe(III) nitrate as magnetic precursor. The hydrophobic property was achieved using the methytrimethoxysilane (MTMS) as co-precursor for surface modification. The so-produced nanocomposite aerogels are monolithic, hydrophobic and magnetic. The interconnected porous structure hosts ~ 6 nm size &#947;-Fe2O3 particles and has a mean pore diameter of 5 nm, and specific surface area (SSA) of 698 m²\/g. Medium range structure of MHA is determined by SAXS which displays the typical fractal power law behaviors with primary particle radius of ~ 1 nm. Magnetic properties of the nanoparticle ensembles hosted in them are studied by means of dc-magnetometry.","palabras_clave":"NANOCOMPOSITES|AEROGELS|SAXS|MAGNETOMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87870,"idioma_id":4,"titulo":"Effect of the heat treatment conditions on the synthesis of Sr-hexaferrite","resumen":"The effect of the heat treatment conditions under oxygen atmosphere on the SrFe12O19 synthesis is analyzed. Effect of partial evacuation of decomposition gases of the organometallic precursor on the phase composition of different samples is studied. An accurate structural analysis of samples obtained between 250ºC and 600ºC is reported. From the structural analysis several secondary phases are identified. The amount of secondary phases can be manipulated through the control of the heat treatment conditions, and therefore, this constitutes a methodology to manipulate the composition and the magnetic properties of the obtained nanopowders. The quantitative determination of phases is performed by structural refinement of X-ray powder patterns, by using Rietveld analysis. Magnetic study is done by magnetization vs. applied magnetic field at room temperature.","palabras_clave":"Strontium hexaferrite|Heat treatment|Oxygen atmosphere"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87871,"idioma_id":4,"titulo":"THE USE OF ELECTROBIOREMEDIATION IN HYDROCARBON  RELEASE AND BIOREMEDIATION.","resumen":"Hydrocarbon bioavailability is a relevant parameter for bioremediation technologies, especially in old contaminated sites. The aim of this work was to apply electrobioremediation (EKB) of sediments with two types of contaminant; in one case, it was an old hydrocarbon contaminant adsorbed by the sediment particle and in the second case, it was a laboratory added contaminant, which included phenanthrene and hexadecane. The removal of the added contaminant was fast, about 30 days in the case of the hexadecane and 61 days in the case of phenanthrene; but on day 91, naphtalin, 1- methylnaphtalin and 2- methyl naphthlin appeared and were then degraded except in the cathode zone. The use of EKB removed and bioremediated the old contaminant contained in the sediment sample.","palabras_clave":"ELECTROBIOREMEDIATION|HYDROCARBON|RELEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87872,"idioma_id":4,"titulo":"Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription","resumen":"Chromosomal instability is a key feature in cancer progression. Recently we have reported that BRCA1 regulates the transcription of several genes in prostate cancer, including ATM (ataxia telangiectasia mutated). Although it is well accepted that ATM is a pivotal mediator in genotoxic stress, it is unknown whether ATM transcription is regulated during the molecular response to DNA damage. Here we investigate ATM transcription regulation in human prostate tumor PC3 cell line. We have found that doxorubicin and mitoxantrone repress ATM transcription in PC3 cells but etoposide and methotrexate do not affect ATM expression. We have demonstrated that BRCA1 binds to ATM promoter and after doxorubicin exposure, it is released. BRCA1 overexpression increases ATM transcription and this enhancement is abolished by BRCA1 depletion. Moreover, BRCA1-BRCT domain loss impairs the ability of BRCA1 to regulate ATM promoter activity, strongly suggesting that BRCT domain is essential for ATM regulation by BRCA1. BRCA1-overexpressing PC3 cells exposed to KU55933 ATM kinase inhibitor showed significant decreased ATM promoter activity compared to untreated cells, suggesting that ATM transcriptional regulation by BRCA1 is partially mediated by the ATM kinase activity. In addition, we have demonstrated E2F1 binding to ATM promoter before and after doxorubicin exposure. E2F1 overexpression diminishes ATM transcription after doxorubicin exposure which is impaired by E2F1 dominant negative mutants. Finally, the co-regulator of transcription CtIP increases ATM transcription. Altogether, BRCA1\/E2F1\/CtIP binding to ATM promoter activates ATM transcription. Doxorubicin exposure releases BRCA1 and CtIP from ATM promoter still keeping E2F1 recruited and, in turn, represses ATM expression.","palabras_clave":"ATM|BRCA1|TRANSCRIPTION|DNA DAMAGE|PROSTATE CANCER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87873,"idioma_id":4,"titulo":"New biostratigraphic data from the Callovian-Oxfordian La Manga Formation, Neuquén Basin, Argentina: evidence from an ammonite condensed level","resumen":"The La Manga Formation constitutes most of the sedimentary record of the Callovian-Oxfordian in the Neuquén Basin. This stratigraphic unit represents the middle part of the Lotena Mesosequence, which is dominated by carbonates with interbedded shales, marls, andoccasional sandstones. Based on detailed stratigraphic work in the stratotype section (La Manga Creek, Mendoza), the depositional environments and the sea-level history of the La Manga Formation have been interpreted. Petrographic and field observations led toidentification of nine facies distributed in two informal units. Unit 1 was deposited on a outer ramp setting, while deposition of unit 2 took place in the intertidal-supratidal environments. A condensed level close to the base of unit 1 has yielded Rehmannia sp., Rehmannia cf.paucicostata (Tornq.) and Homoeoplanulites sp., from the Lower Callovian Bodenbenderi-Proximum Zones, and Peltoceratoides sp.and Rursiceras sp. from the Upper Callovian and also in the Lower Oxfordian Peltoceratoides-Parawedekindia Zone. The condensedlevel is overlain by a Middle Oxfordian succession characterized by Perisphinctes (?Arisphinctes) sp., Perisphinctes (?Kranaosphinctes) sp., Mirosphinctes sp., Perisphinctes (?Antilloceras) cf. prophetae Gygi &amp; Hill., Perisphinctes (?Otosphinctes) sp., Perisphinctes(?Subdiscosphinctes) sp., and Perisphinctes (?Kranaosphinctes) cf. decurrens (Buck.) of the Perisphinctes-Araucanites Zone, which was correlated with the upper part of the Cordatum Standard Zone to the Transversarium Standard Zone, and probably to the lower partof the Bifurcatus Standard Zone. Unit 2 has yielded small Mirosphinctes sp., indicating an Oxfordian age. The sharp contact between the outer ramp facies of unit 1 and the overlying intertidal-supratidal facies of unit 2 can be interpreted as the result of an abrupt fall(forced regression) of the relative sea level during the end of Middle Oxfordian or Upper Oxfordian. These results could be used for comparison with other localities in the Neuquén Basin providing additional data for Lower Callovian-Middle Oxfordian deposits.","palabras_clave":"Carbonate ramp|forced regression|Jurassic ammonites|Neuquén Basin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87874,"idioma_id":4,"titulo":"?Spermatogenesis and changes in testicular structure during the reproductive cycle in Cichlasoma dimerus (Teleostei, Perciformes)?","resumen":"The present study aimed at analyzing spermatogenesis and the changes occurring  in the testis throughout the reproductive cycle in the South American perciform  fish Cichlasoma dimerus. Testes were studied using light and electron  microscopy techniques. This species has an unrestricted lobular testis composed  of two compartments: germinal, containing Sertoli and germ cells, exhibiting a  cystic mode of spermatogenesis; and interstitial, composed of Leydig cells and  connective tissue elements. Spermatozoa belong to the anacrosomal type I aquasperm  and possess two flagella, this being the first report of an externally fertilizing  cichlid exhibiting biflagellate sperm. Under laboratory conditions, C. dimerus  proved to be a multiple spawner throughout the year, with a season of higher  reproductive activity extending from September to March, during which fish  spawned on average every 29.4 days. Changes in the germinal epithelium and  the germ cell stages present allowed the description of five reproductive classes:  regressed, early, mid-, and late maturation, and regression. During the high  reproductive season, each cycle went through the first four classes. The regressed  class overlapped with the late maturation class, because sperm was being  released while spermatogonia were proliferating. The regression class occurred  solely in sexually inactive males during the period of low reproductive activity.","palabras_clave":"SPERMATOGENESIS|TESTICULAR STRUCTURE|CICHLIDAE|REPRODUCTIVE CYCLE|BIFLAGELLATE SPERMATOZOA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87875,"idioma_id":4,"titulo":"Oxidative stress due to aluminium exposure induces eryptosis which is prevented by erythropoietin","resumen":"The widespread use of aluminum (Al) provides easy exposure of humans to the metal and its accumulation remains a potential problem. In vivo and in vitro assays have associated Al overload with anemia. To better understand the mechanisms by which Al affects human erythrocytes, morphological and biochemical changes were analyzed after long-term treatment using an in vitro model. The appearance of erythrocytes with abnormal shapes suggested metal interaction with cell surface, supported by the fact that high amounts of Al attached to cell membrane. Long-term incubation of human erythrocytes with Al induced signs of premature erythrocyte death (eryptosis), such as phosphatidylserine externalization, increased intracellular calcium, and band 3 degradation. Signs of oxidative stress, such as significant increase in reactive oxygen species in parallel with decrease in the amount of reduced glutathione, were also observed. These oxidative effectswere completely prevented by the antioxidant N-acetylcysteine. Interestingly, erythrocytes were also protected from the prooxidative action of Al by the presence of erythropoietin (EPO). In conclusion, results provide evidence that chronic Al exposure may lead to biochemical andmorphological alterations similar to those shown in eryptosis induced by oxidant compounds in human erythrocytes. The antieryptotic effect of EPO may contribute to enhance the knowledge of its physiological role on erythroid cells. Irrespective of the antioxidant mechanism, thisproperty of EPO, shown in this model of Al exposure, let us suggest potential benefits by EPO treatment of patients with anemia associated to altered redox environment. J. Cell. Biochem. 9999: 1?9, 2012.  2011 Wiley Periodicals, Inc.","palabras_clave":"Aluminum|Erythrocytes|Oxidative Stress|Erythropoietin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87876,"idioma_id":4,"titulo":"Phloxine B as a probe for entrapment in microcrystalline cellulose","resumen":"The photophysical behaviour of phloxine B adsorbed onto microcrystalline cellulose was evaluated by reflectance spectroscopy and laser induced time-resolved luminescence in the picosecond-nanosecond and microsecond-millisecond ranges. Analysis of the absorption spectral changes with concentration points to a small tendency of the dye to aggregate in the range of concentrations under study. Prompt fluorescence, phosphorescence and delayed fluorescence spectral decays were measured at room temperature and 77 K, without the need of sample degassing because cellulose protects triplet states from oxygen quenching. In all cases, spectral changes with time and lifetime distribution analysis were consistent with the dye coexisting in two different environments: dyes tightly entrapped between polymer chains in crystalline regions of cellulose showed longer fluorescence and phosphorescence lifetimes and more energetic triplet states, while dyes adsorbed in more amorphous regions of the support showed shorter lifetimes and less energetic triplet states. This behaviour is discussed in terms of the different dye-support interactions in both kinds of adsorption sites.","palabras_clave":"PHLOXINE B|HETEROGENEOUS SYSTEMS|PHOSPHORESCENCE|MICROENVIRONMENTAL EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87877,"idioma_id":4,"titulo":"Eosin Y Triplet State as a Probe of Spatial Heterogeneity in Microcrystalline Cellulose","resumen":"The photophysical behavior of eosin Y adsorbed onto microcrystalline cellulose was evaluated by reflectance spectroscopy, steady-state fluorescence spectroscopy and laser induced timeresolved luminescence. On increasing the concentration of the dye, small changes in absorption spectra, fluorescence redshifts and fluorescence quenching are observed. Changes in absorption spectra point to the occurrence of weak exciton interactions among close-lying dye molecules, whereas fluorescence is affected by reabsorption and excitation energy trapping. Phosphorescence decays are concentration independent as a result of the negligible exciton interaction of dye pairs in the triplet state. Lifetime distribution and bilinear regression analyses of timeresolved phosphorescence and delayed fluorescence spectra reveal the existence of two different environments: long-lived, more energetic triplet states arise from dyes tightly entrapped within the cellulose chains, while short-lived, less-energetic states result from dyes in more flexible environments. Stronger hydrogen bond interactions between the dye and cellulose hydroxyl groups lead in the latter case to a lower triplet energy and faster radiationless decay. These effects, observed also at low temperatures, are similar to those encountered in several amorphous systems, but rather than being originated in changes in the environment during the triplet lifetime, they are ascribed in this case to spatial heterogeneity.","palabras_clave":"EOSIN Y|PHOSPHORESCENCE|MICROCRYSTALLINE CELLULOSE|SPATIAL HETEROGENEITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87878,"idioma_id":4,"titulo":"A Simplified Undergraduate Laboratory Experiment To Evaluate the Effect of the Ionic Strength on the Equilibrium Concentration Quotient of the Bromcresol Green Dye","resumen":"A modified laboratory experiment for undergraduate students is presented to evaluate the effects of the ionic strength, I, on the equilibrium concentration quotient, Kc, of the acid-base indicator bromcresol green (BCG). The two-step deprotonation of the acidic form of the dye (sultone form), as it is dissolved in water, yields suitable hydronium concentration in the solution to carry out the experiment successfully and avoids the use of any buffer solution to fix the hydronium concentration of the media. The 95% confidence interval for the slope parameter (-2.08&nbsp;+\/- 0.13), obtained from the linear fit of pKc versus I1\/2\/ (1 + 2.30*I1\/2) plot, contains the theoretical value of -2.04 predicted by the Debye-Hückel extended law. From the intercept, a value for the equilibrium dissociation constant of BCG, pK = (4.91&nbsp;+\/- 0.02), is obtained, showing a reasonable agreement with literature data. The simplification makes it possible for students to complete the experiment in the course of an ordinary 3-h laboratory session.","palabras_clave":"BROMCRESOL GREEN|EQUILIBRIUM CONCENTRATION QUOTIENT|IONIC STRENGTH|DEBYE-HUCKEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87879,"idioma_id":4,"titulo":"Physiological and morphological short term responses to light and temperature in two Nothofagus species of Patagonia, South-America","resumen":"The study of plant responses to environmental stress factors is   essential for management of plant systems and for anticipating              their response to climate change. The main goal of this   study was to determine morphological and physiological responses of              Nothofagus obliqua and N. nervosa seedlings to   light and temperature, two of the main stress factors acting in their   current natural distribution in NW Patagonia.              Responses to light were evaluated analyzing growth and   survival, as well as morphological and physiological traits related              to them, in seedlings subjected to three contrasting light   conditions (full-sun conditions, 50% of sunlight and 20% of sunlight)              during one growth season. Temperature photosynthetic   responses were evaluated in seedlings subjected to temperature   treatments              between &#8722;5 and 40°C for 2 and 4 h. Growth rate and biomass   partition were similar between light treatments in both species.              High apical meristem damage and decreased photosynthetic   capacity of preformed leaves were observed under full-sun conditions,              suggesting that high light levels have a deleterious effect   on plant yield. Both species produced neoformed leaves during              the growing season with better photosynthetic capacity than   preformed leaves under full sun conditions, contributing to plant              acclimation. Almost no plasticity was observed in   morphological traits in response to shade. Both species differed in   optimum              temperature for photosynthesis, with a wider temperature   range at which high photosynthesis is maintained in N. obliqua.   In both species the higher values of net photosynthetic rate were found   at higher temperatures than the mean annual temperature              of its current natural distribution range. Under no   water-stress conditions, future higher temperatures could increase   carbon              fixation of these species, with a little advantage of N. obliqua if temperature variance is high. Synergy effect of various environmental stress factors, particularly considering cultivation              of these species outside their current natural distribution sites require further studies.","palabras_clave":"acclimation|neoformation|photoinhibition|preformation|thermal stress"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87880,"idioma_id":4,"titulo":"Short- and long-term responses to seasonal drought in ponderosa pines growing at different plantation densities in Patagonia, South America","resumen":"Trees drought responses could be developed in the short- or in the long-term, aiming at sustaining carbon fixation and water use efficiency (WUE). The objective of this study was to examine short- and long-term adjustments occurring in different size Pinus ponderosa Dougl. ex P. &amp; C. Laws trees in response to seasonal drought when they are growing under different competition level. The following variables were studied: branch and stem hydraulic conductivity, canopy and stomatal conductance (gc, gs), transpiration (E), photosynthesis (Amax), wood d13C (as a proxy of intrinsic WUE), leaf to sapwood area ratio (AL:As) and growth in the biggest (B) and the smallest (S) trees of high (H) and low (L) density stands. AL:As was positively correlated with tree size and negatively correlated with competition level, increasing leaf hydraulic conductance in H trees. Accordingly, higher gc and E per unit AL were found in H than in L trees when soil water availability was high, but decreased abruptly during dry periods. BL trees maintained stable gc and E values even during the summer drought. The functional adjustments observed in H trees allow them to maintain their hydraulic integrity (no apparent ks losses), but their stem and leaf growth were severely affected by drought events. iWUE was similar between all tree groups in a wet season, whereas it significantly decreased in SH trees in a dry season suggesting that when radiation and water are co-limiting gas exchange, functional adjustments not only affect absolute growth, but also WUE.","palabras_clave":"Pinus ponderosa|water relations|canopy conductance|drought resistance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87881,"idioma_id":4,"titulo":"Performance of Planar and Cylindrical Carbon Electrodes at Sedimentary Microbial Fuel Cells","resumen":"This paper presents data obtained using an indigenous microbial community contained inanaerobic sediments (mud) collected from the shore of the Río de La Plata River (SouthAmerica). After the sedimentary microbial fuel cells were assembled the evolution ofcurrent and power vs. time was studied. Two types of commercially available graphitematerials were used as electrodes, which differ mainly in shape and size. In someexperiments, an external carbon source (acetate) increased the power generation rate. Themaximum power density observed in the aforementioned condition was 19.57 ± 0.35 and8.72 ± 1.39 mW\/m2 using rod and graphite disk electrodes, respectively. The betterperformance of the rod electrodes can be explained, at least in part, by an enhanced rate ofmass transport by radial diffusion. DGGE fingerprints were used to study the electrogeniccommunity growing over the electrodes. ","palabras_clave":"DGGE|ELECTROGENIC BACTERIA|MICROBIAL FUEL CELL|BIOFILM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87882,"idioma_id":4,"titulo":"A counterpoint between computer simulations and biological experiments to train new members of a laboratory of physiological sciences","resumen":"When new members join a working group dedicated to scientific research, several changes occur in the group´s dynamics. From a teaching point of view, a subsequent challenge is to develop innovative strategies to train new staff members in creative thinking, which is the most complex and abstract skill in the cognitive domain according to Bloom´s revised taxonomy. In this sense, current technological and digital advances offer new possibilities in the field of education. Computer simulation and biological experiments can be used together as a combined tool for teaching and learning sometimes complex physiological and biophysical concepts. Moreover, creativity can be thought of as a social process that relies on interactions among staff members. In this regard, the acquisition of cognitive abilities coexists with the attainment of other skills from psychomotor and affective domains. Such dynamism in teaching and learning stimulates teamwork and encourages the integration of members of the working group. A practical example, based on the teaching of biophysical subjects such as osmosis, solute transport, and membrane permeability, which are crucial in understanding the physiological concept of homeostasis, is presented.","palabras_clave":"Simulation|Experimental|Education|Physiology|Creativity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87883,"idioma_id":4,"titulo":"Shear viscosity from thermal fluctuations in relativistic conformal fluid dynamics","resumen":"Within the framework of relativistic fluctuating hydrodynamics we compute the contribution of thermal fluctuations to the effective infrared shear viscosity of a conformal fluid, focusing on quadratic (in fluctuations), second order (in velocity gradients) terms in the conservation equations. Our approach is based on the separation of hydrodynamic fields in soft and ultrasoft sectors, in which the effective shear viscosity arises due to the action of the soft modes on the evolution of the ultrasoft ones. We find that for a strongly coupled fluid with small shear viscosity?to?entropy ratio eta\/s the contribution of thermal fluctuations to the effective shear viscosity is small but significant. Using realistic estimates for the strongly coupled quark?gluon plasma created in heavy ion collisions, we find that for eta\/s close to the AdS\/CFT lower bound 1\/(4pi) the correctionis positive and at most amounts to 10% in the temperature range 200?300 MeV, whereas for larger values eta\/s &#8764; 2\/(4pi) the correction is negligible. For weakly coupled theories the correction is very small even for eta\/s = 0.08 and can be neglected.","palabras_clave":"SHEAR VISCOSITY|THERMAL FLUCTUATIONS|CONFORMAL FLUID DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87884,"idioma_id":4,"titulo":"Production of thermal photons in viscous fluid dynamics with temperature-dependent shear viscosity","resumen":"We compute the spectrum of thermal photons created in Au+Au collisions at $\\sqrt{s_{NN}}=200$ GeV, taking into account dissipative corrections in production processes corresponding to the quark--gluon plasma and hadronic phases. To describe the evolution of the fireball we use a viscous fluid dynamic model with different parametrizations for the temperature--dependence of $\\eta\/s$. We find that the spectrum significantly depends on the values of $\\eta\/s$ in the QGP phase, and is almost insensitive to the values in the hadronic phase. We also compare the influence of the&nbsp; temperature--dependence of $\\eta\/s$ on the spectrum of thermal photons to that of using different equations of state in the fluid dynamic simulations, finding that both effects are of the same order of magnitude.","palabras_clave":"RELATIVISTIC VISCOUS HYDRODYNAMICS|THERMAL PHOTONS|SHEAR VISCOSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87885,"idioma_id":4,"titulo":"Effective dynamics of a non-Abelian plasma out of equilibrium","resumen":"Starting from kinetic theory, we obtain a nonlinear dissipative formalism describing the nonequilibrium evolution of scalar colored particles coupled selfconsistently to nonabelian classical gauge fields. The link between the one-particle distribution function of the kinetic description and the variables of the effective theory is determined by extremizing the entropy production. This method does not rely on the usual gradient expansion in fluid dynamic variables, and therefore the resulting effective theory can handle situations where these gradients (and hence the&nbsp; momentum-space anisotropies) are expected to be large.&nbsp; The formalism presented here, being computationally less demanding than kinetic theory, may be useful as a simplified model of the dynamics of color fields during the early stages of heavy ion collisions and in phenomena related to parton energy loss.","palabras_clave":"NON-ABELIAN PLASMA|EFFECTIVE THEORY|NONEQUILIBRIUM|ENTROPY PRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87886,"idioma_id":4,"titulo":"Host use by botflies Philornis sp. in a passerine community in central Argentina","resumen":"We studied host use by parasitic botflies (Philornis sp.) in a passerine community in central Argentina and analyzed characteristics of nests and hosts associated with botfly parasitism. We conducted a four-year field study as well as a bibliographical survey where we determined: presence of botfly parasitism, type of nest, presence of green material and small sticks in the nest, average height of the nest, date of last nesting attempt during the breeding season and egg volume (as a surrogate of species body mass). Our field data study of three birds species showed that botflies parasitized Troglodytes aedon (25% of nests), but not Sicalis flaveola and Tachycineta leucorroha in spite of nesting in similar boxes, at the same place and during the same time of the year. However T. aedon built nests using dry material while S. flaveola and T. leucorroha used green material. The analysis of published data (35 species considered) showed a negative association between botfly parasitism and presence of green material in the nest, and a positive association between botfly parasitism and presence of small sticks in the nest and date of the last nesting attempt during the breeding season. Our results indicate that the materials used to build the nest and the extent of the breeding season are factors that influence host use by botflies in central Argentina.","palabras_clave":"Ectoparasites|Botflies|Host use|Birds"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87887,"idioma_id":4,"titulo":"Host-parasite coevolution beyond the nestling stage? Mimicry of host fledglings by the specialist screaming cowbird","resumen":"Egg mimicry by obligate avian brood parasites and host rejection of non-mimetic eggs are well-known textbook examples of host-parasite coevolution. In contrast, reciprocal adaptations and counteradaptations beyond the egg stage in brood parasites and their hosts have received less attention. The screaming cowbird (Molothrus rufoaxillaris) is a specialist obligate brood parasite whose fledglings look identical to those of its primary host, the baywing (Agelaioides badius). Such a resemblance has been proposed as an adaptation in response to host discrimination against odd-looking young, but evidence supporting this idea is scarce. Here we examined this hypothesis by comparing the survival rates of young screaming cowbird and non-mimetic shiny cowbirds (M. bonariensis) cross-fostered to baywing nests and quantifying the similarity in plumage colour and begging calls between host and cowbird fledglings. Shiny cowbirds suffered higher post-fledging mortality rates (83%) than screaming cowbirds (0%) due to host rejection. Visual modelling revealed that screaming cowbirds, but not shiny cowbirds, were indistinguishable from host young in plumage colour. Similarly, screaming cowbirds matched baywings? begging calls more closely than shiny cowbirds. Our results strongly support the occurrence of host fledgling mimicry in screaming cowbirds and suggest a role of visual and vocal cues in fledgling discrimination by baywings.","palabras_clave":"brood parasitism|mimicry|chick rejection|cowbird"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87888,"idioma_id":4,"titulo":"Survival to heat stress with and without heat-hardening in Drosophila melanogaster: interactions with larval density","resumen":"Survival to a potentially lethal stress of high temperature is a genetically variable trait of thermal adaptation in many organisms. Living organisms cope with heat stress by basal or induced thermo-resistance. Here, we tested quantitative trait loci (QTL) for heat-stress survival in Drosophila melanogaster, with and without a cyclic heat hardening pre-treatment, for flies that were reared at both low (LD) and high (HD) density. Mapping populations were two panels of recombinant inbred lines (RIL) which were previously constructed from heat-stress-selected stocks: RIL-D48 and RIL-SH2, derived from backcrosses to the stock of low and high heat resistance, respectively. Heat-stress survival increased with heat hardening in both LD and HD flies. Besides, heat-stress survival increased consistently with density in non-hardened flies. There was a significant interaction between heat-hardening and density effects in RIL-D48. Several QTL were significant at both density and hardening treatments. Many QTL overlapped with thermotolerance-QTL identified for other traits in previous studies based on low density cultures only. However, three new QTL were found in HD only (cytological ranges: 12E-16F6; 30A3-34C2; 49C-50C). Previously found thermotolerance QTL were also significant for flies from HD cultures.","palabras_clave":"HIGH TEMPERATURE STRESS|EPISTASIS|QUANTITATIVE TRAIT LOCI|THERMOTOLERANCE|CANDIDATE GENES|THERMAL RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87889,"idioma_id":4,"titulo":"The Rigths of Indigenous People to their Own Law","resumen":"The aim of this paper is to analyze an interesting case about the rights of the indigenous peoples to their own law. In this case, an Argentinean court had to solve a conflict originated in the hypothetical right of a member of the wichí community to have sexual intercourse with his concubine?s daughter, based on an alleged indigenous custom.  The paper tries to prove that the claim of the accused is unacceptable, because it affects the universality of some of the human rights present in the case.","palabras_clave":"Multiculturalism|Human Rights|Asimilacionism|Universalism"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87890,"idioma_id":4,"titulo":"Binary mixtures of azinphos-methyl oxon and chlorpyrifos oxon produce in vitro synergistic cholinesterase inhibition in Planorbarius corneus","resumen":"Abstract    In this study, the cholinesterase (ChE) and carboxylesterase (CES) activities present in whole organism homogenates from Planorbarius corneus and their in vitro sensitivity to OP pesticides were studied. Firstly, a characterization of ChE and CES activities using different substrates and selective inhibitors was performed. Secondly, the effects of azinphos-methyl oxon (AZM-oxon) and chlorpyrifos oxon (CPF-oxon), the potent oxygen analogs of the OP insecticides AZM and CPF, on ChE and CES activities were evaluated. Finally, it was analyzed whether binary mixtures of the pesticide oxons causes additive, antagonistic or synergistic ChE inhibition in P. corneus homogenates. The results showed that the extracts of P. corneus preferentially hydrolyzed acetylthiocholine (AcSCh) over propionylthiocholine (PrSCh) and butyrylthiocholine (BuSCh). Besides, AcSCh hydrolyzing activity was inhibited by low concentrations of BW284c51, a selective inhibitor of AChE activity, and by high concentrations of substrate. These facts indicate the presence of a typical AChE activity in this species. However, the different dose-response curves observed with BW284c51 when using PrSCh or BuSCh instead of AcSCh suggests the presence of at least another ChE activity. This would probably correspond to an atypical BuChE. Regarding CES activity, the highest specific activity was obtained when using 2-naphthyl acetate (2-NA), followed by 1-NA, p-nitrophenyl acetate (p-NPA) and p-nitrophenyl butyrate (p-NPB). The comparition of the IC50 values revealed that, regardless of the substrate used, CES activity was approximately one order of magnitud more sensitive to AZM-oxon than ChE activity. Although ChE activity was very sensitive to CPF-oxon, CES activity measured with 1-NA, 2-NA, and p-NPA was poorly inhibited by this pesticide. In contrast, CES activity measured with p-NPB was equally sensitive to CPF-oxon than ChE activity. Several especific binary combinations of AZM-oxon and CPF-oxon caused synergistic ChE inhibition in P. corneus homogenates. The degree of synergism tended to increase as the ratio of AZM-oxon to CPF-oxon decreased. These results suggest that synergism is likely to occur in P. corneus snails exposed in vivo to binary mixtures of the OPs AZM and CPF.","palabras_clave":"CARBOXYLESTERASE|CHOLINESTERASE|INVERTEBRATE|MIXTURE|PESTICIDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87891,"idioma_id":5,"titulo":"Diagnostico de Leptospirosis Humana: evaluación de la Aglutinación Macroscópica en diferentes etapas de la enfermedad.","resumen":"OBJETIVO: Evaluar la aglutinación macroscópica con antígeno termorresistente (TR) como tamiz diagnóstico de leptospirosis humana en diferentes etapas de la enfermedad. MATERIAL Y MÉTODOS:La definición de casos se basó en la microaglutinación (MAT), recuento de leucocitos y neutrofilia. Se incluyeron 218 casos confirmados y 242 no casos. Cada muestra del banco de sueros del laboratorio del Instituto Nacional de Enfermedades Respiratorias de Santa Fe, Argentina, de 2008 a 2010, se clasificó según días de evolución en tres etapas: primera (&lt;10 días), segunda (10- 25 días) y tercera (&gt;25 días). RESULTADOS: La sensibilidad hallada fue: 71.1, 93.4 y 95.6% para etapas 1, 2 y 3 respectivamente. La especificidad varió de 79.0 a 69.2%. La variabilidad intra e interoperador fue moderada. CONCLUSIÓN: La variabilidad del TR, su baja sensibilidad en la primera etapa y baja especificidad en todas las etapas de la enfermedad sugieren que sería indispensable la incorporación de nuevos métodos diagnósticos de tamiz para la detección precoz de casos en nuestro país, y países donde aún se apliquen este tipo de métodos. ","palabras_clave":"Leptospirosis|Diagnóstico|Pruebas serológicas|Pruebas de aglutinación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87892,"idioma_id":4,"titulo":"Effective detection of Mycobacterium bovis-infected dairy herds using PCR in bulk tank milk samples","resumen":"Bovine tuberculosis (bTB) is a chronic and zoonotic disease due to Mycobacterium bovis. The tuberculosis eradication campaign carried out in Argentina has considerably improved the health situation of the herds. Here we evaluated a strategy to detect M. bovis-infected herds by Touch-Down IS6110 polymerase chain reaction (PCR) in bulk tank raw milk from dairy farms. We evaluated 177 samples from herds with the official tuberculosis free certificate (TFC) and 80 from herds without the certificate, non-tuberculosis-free certificate (NTFC), from 10 departments of Santa Fe province, Argentina. To avoid the effect of Taq polymerase inhibitors, a dilution of DNA template was performed. Positive PCR results were obtained in 102 (40%) of the samples, whereas negative ones were obtained in 155 (60%) of the samples. Importantly, 44% of NTFC and 38% of TFC samples were positive. All samples were subjected to culture in Löwenstein Jensen and Stonebrink media with no positive isolation. The negative predictive value (NPV) of PCR in the TFC group was 95%, while the positive predictive value (PPV) of PCR in the NTFC group was 51%. Based on these results, this work proposes a method that should be applied regularly to detect M. bovis--infected dairy herds, complementary to the official test of tuberculin, or purifed protein derivative (PPD), to control dairy herds, especially those free of tuberculosis.","palabras_clave":"MYCOBACTERIUM BOVIS|PCR|BULK TANK"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87893,"idioma_id":4,"titulo":"Modulation of innate immunity in chickens induced by in vivo administration of baculovirus","resumen":"Baculoviruses stimulate cytokine production in mammalian cells. They induce a strong innate immune response in animals and have adjuvant properties. The purpose of this work was to study the in vivo effect of baculovirus on chicken innate immune response. SPF chickens were inoculated intravenously with Autographa californica nuclear polyhedrosis virus (BV). Three hours later, chickens were bled, euthanized and their spleen, duodenum and cecal tonsils were excised in order to take samples for RNA extraction and real time   PCR, and to isolate lymphocytes, which were stained and analyzed by flow cytometry.  The results obtained showed that baculovirus inoculation up-regulates the expression ofIFNg, IL-6 and LITAF in spleen cells. This result (IFNg) correlated with that obtained by ELISA  which showed a very strong increase of IFNg in chicken plasma. Flow cytometry analysis revealed that BV inoculation induced in spleen an increase in the percentage of monocyte\/macrophage population together with an increase in CD3+CD4+T lymphocytes.  On the other hand, BV inoculation decreased the percentage of CD3+CD4+T lymphocytes and increased the percentage of NK cells in cecal tonsils. However, intraepithelial lymphocytes of the gut did not show differences between BV and control treated animals. Even though further studies in order to understand the mechanisms by which BVs affect the avian immune    response are needed, results obtained in the present work demonstrate the ability of BVs to stimulate the innate immunity in chickens, modifying the expression pattern of related genes and the profile of the immune cells involved.","palabras_clave":"Avian innate immunity|Baculovirus|Flow cytometry|Real time PCR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87894,"idioma_id":4,"titulo":"Association between milking practices and psychrotrophic bacterial counts in bulk tank milk","resumen":"The objective of this work was to determine on-farm risk factors for psychrotrophic bacterial counts in bulk tank milk from dairy farms in Argentina. Raw milk samples from bulk tanks of 27 dairy farms were examined for total psychrotrophic counts (TPC), proteolytic psychrotrophic counts (PPC) and lipolytic psychrotrophic counts (LPC) (dependent or outcome variables). A survey recording infrastructure conditions, milking equipment and milking management (independent variables) was performed. Bivariate association proofs and logistic regression analyses were used to determine association between independent variables and psychrotrophic bacterial counts. Milk cooled in plate heat exchangers or barrel tanks were 16.39 and 10.52 times more likely to yield TPC and PPC above the standard established for high quality milk compared with milk cooled in bulk tanks, respectively. Periodic cleaning of cooling tanks (3 times a week or daily) was associated with lower TPC (approximately 1.5 log CFU\/ml) than weekly cleaning frequency and farms where milkers did not wash their hands during milking time were 7.81 times more likely to have higher PPC. No association was found between LPC and any of the independent variables. The only variable associated with TPC and PPC in a logistic regression model was the refrigeration system used on the farm. Dairy farms that possessed bulk milk cooling tanks yielded the lowest bacterial counts. Results of this study highlight the importance of both the type of cooling system used on the farm and its adequate hygienic maintenance for obtaining low pshychrotrophic counts at dairy farm.","palabras_clave":"psychrotrophic bacteria|bulk tank milk|risk factors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87895,"idioma_id":5,"titulo":"Evaluación de cultivares de soja transgénica. Resultado de las campañas 2010\/11 y 2011\/12.","resumen":"En las campañas 2010\/11 y 2011\/12 se instalaron en el predio de la E.E.A. Rafaela del INTA dos ensayos de sojas RG en siembra directa con 40 cultivares de los grupos de maduración III, IV, V, VI y VII.&nbsp; En cada campaña se sembraron en las siguientes fechas: el 05 de noviembre y el 03 de diciembre de 2010 para las siembras de 1ª y de 2ª respectivamente y el 03 de noviembre y 02 de diciembre para el año 2011 en surcos espaciados a 0,52 m para ambas épocas. En la campaña 2010-11, con una distribución de precipitaciones más cercana a la media histórica de la región, los cultivares sembrados en la 1ª época manifestaron un buen comportamiento general por lo que no justificaría el uso de ciclos tan largos, mientras que en la 2ª fecha los GM VI y VII fueron los que lograron los rendimientos más destacados.En la campaña 2011-12 sobre suelos de características similares pero en un ambiente productivo más limitado, los rendimientos más afectados fueron los de los cultivares más cortos (GM III y IV); en estas condiciones siempre se comportan como más estables, los materiales pertenecientes a GM intermedios-largos (GM VI y VII) tanto en siembras de 1ª como de 2ª. ","palabras_clave":"SOJA|CULTIVARES|CAMPAÑAS |GRUPOS DE MADURACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87896,"idioma_id":5,"titulo":"Fechas de siembra, grupos de maduración y espaciamientos entre surcos en soja. Campañas 2011\/12.","resumen":"Participaron los siguientes materiales: RA 338 (grupo III de Santa Rosa), SRM 4901 (grupo IV de Sursem), NA 5509 (grupo V de Nidera), DM 6.2 (grupo VI de Don Mario) y RA 732 (grupo VII de Santa Rosa). Cada cultivar se sembró en cuatro fechas ( 28 de octubre, 17 de noviembre y &nbsp;06 de diciembre de 2011 y 12 de enero de 2012) con dos espaciamientos de 0,35 y 0,52 m entre líneas. Las densidades utilizadas fueron de 23 y 28 semillas\/m lineal de surco para cada espaciamiento, respectivamente.Cuando la disponibilidad de agua a fines de primavera-comienzo de verano es escasa (diciembre), los más afectados son la primera fecha de siembra y los GM más cortos (III y IV). En años de precipitaciones escasas como el presente, los cultivares de ciclo más largo (GM VI y VII) se comportan como más estables. Si bien la siembra de noviembre continúa siendo muy adecuada para todos los cultivares y espaciamientos, en esta oportunidad siembras más tardías de GM largos han logrado un buen rendimiento por las lluvias ocurridas a fin del verano y comienzo del otoño. Además, en situaciones de estrés hídrico se plantea una clara preferencia hacia las siembras a menor espaciamiento sobre todo con los GM cortos. En años de precipitaciones escasas como el presente, los cultivares de ciclo más largo (GM VI y VII) se comportan como más estables. Si bien la siembra de noviembre continúa siendo muy adecuada para todos los cultivares y espaciamientos, en esta oportunidad siembras más tardías de GM largos han logrado un buen rendimiento por las lluvias ocurridas a fin del verano y comienzo del otoño. Además, en situaciones de estrés hídrico se plantea una clara preferencia hacia las siembras a menor espaciamiento sobre todo con los GM cortos. En años de precipitaciones escasas como el presente, los cultivares de ciclo más largo (GM VI y VII) se comportan como más estables. Si bien la siembra de noviembre continúa siendo muy adecuada para todos los cultivares y espaciamientos, en esta oportunidad siembras más tardías de GM largos han logrado un buen rendimiento por las lluvias ocurridas a fin del verano y comienzo del otoño. Además, en situaciones de estrés hídrico se plantea una clara preferencia hacia las siembras a menor espaciamiento sobre todo con los GM cortos. ","palabras_clave":"FECHAS DE SIEMBRA|GRUPOS DE MADURACIÓN|ESPACIAMIENTOS|SOJA TRANSGÉNICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87897,"idioma_id":4,"titulo":"Effect of heat treatment and spray drying on lactobacilli viability and resistance to simulated gastrointestinal digestion","resumen":"Commercial probiotic bacteria are delivered mainly as frozen or freeze-dried cultures. However, spray drying is a lower cost technology that could be used for the production of probiotic cultures. In this work we aimed at screening among lactobacilli strains for candidates able to survive to spray drying and to study the effects of a preliminary mild heat treatment and different food matrices on post-drying survival and simulated gastric acid resistance. Heat resistance (survival to exposure at 60 °C for 5 min) in MRS broth or in 10% (wt\/vol) skim milk was assessed in 22 strains of Lactobacillus casei, Lactobacillus paracasei, Lactobacillus acidophilus andLactobacillus casei, Lactobacillus paracasei, Lactobacillus acidophilus and Lactobacillus plantarum. Five strains (L. casei Nad, L. plantarum com, L. paracasei A13, L. plantarum 8329 and. Five strains (L. casei Nad, L. plantarum com, L. paracasei A13, L. plantarum 8329 and L. acidophilus A9) were selected for spray drying in 20% (wt\/vol) skim milk and storage at 5, 25 or 37 °C for 75 days. For L.p. A13, L.p. com and L.a. A9 no differences in cell viability were observed due to spray drying. However, for L.c. Nad and L.p. 8329 cell death due to spray drying was 0.16 and 0.49 log orders CFU ml&#8722;1A9) were selected for spray drying in 20% (wt\/vol) skim milk and storage at 5, 25 or 37 °C for 75 days. For L.p. A13, L.p. com and L.a. A9 no differences in cell viability were observed due to spray drying. However, for L.c. Nad and L.p. 8329 cell death due to spray drying was 0.16 and 0.49 log orders CFU ml&#8722;1L.p. A13, L.p. com and L.a. A9 no differences in cell viability were observed due to spray drying. However, for L.c. Nad and L.p. 8329 cell death due to spray drying was 0.16 and 0.49 log orders CFU ml&#8722;1L.c. Nad and L.p. 8329 cell death due to spray drying was 0.16 and 0.49 log orders CFU ml&#8722;1 when a mild heat treatment (52 °C for 15 min) was applied and 0.85 and 0.95 log cycles, respectively, without preliminary mild heat treatment, showing that heat treatment enhanced survival to spray drying. The application of a heat treatment was effective for enhancing survival during storage of L.p. 8329, irrespective of the storage temperature and period. No significant cell loss at 5 and 25 °C was observed for L.c. Nad. For this strain, at 37 °C no cell counts of lactobacilli were observed after 30 days of storage. For L.a. A9, L.p. com and L.p. A13 a reduction in cell viability was observed along storage as temperature increased. Resistance to simulated gastrointestinal digestion was enhanced by spray drying. The application of a mild heat treatment before spray drying may enhance cell survival during storage and the resistance to gastrointestinal digestion. Spray drying might be used for enhancing cell functionality in a strain-dependant way.L.p. 8329, irrespective of the storage temperature and period. No significant cell loss at 5 and 25 °C was observed for L.c. Nad. For this strain, at 37 °C no cell counts of lactobacilli were observed after 30 days of storage. For L.a. A9, L.p. com and L.p. A13 a reduction in cell viability was observed along storage as temperature increased. Resistance to simulated gastrointestinal digestion was enhanced by spray drying. The application of a mild heat treatment before spray drying may enhance cell survival during storage and the resistance to gastrointestinal digestion. Spray drying might be used for enhancing cell functionality in a strain-dependant way.ficant cell loss at 5 and 25 °C was observed for L.c. Nad. For this strain, at 37 °C no cell counts of lactobacilli were observed after 30 days of storage. For L.a. A9, L.p. com and L.p. A13 a reduction in cell viability was observed along storage as temperature increased. Resistance to simulated gastrointestinal digestion was enhanced by spray drying. The application of a mild heat treatment before spray drying may enhance cell survival during storage and the resistance to gastrointestinal digestion. Spray drying might be used for enhancing cell functionality in a strain-dependant way.L.c. Nad. For this strain, at 37 °C no cell counts of lactobacilli were observed after 30 days of storage. For L.a. A9, L.p. com and L.p. A13 a reduction in cell viability was observed along storage as temperature increased. Resistance to simulated gastrointestinal digestion was enhanced by spray drying. The application of a mild heat treatment before spray drying may enhance cell survival during storage and the resistance to gastrointestinal digestion. Spray drying might be used for enhancing cell functionality in a strain-dependant way.L.a. A9, L.p. com and L.p. A13 a reduction in cell viability was observed along storage as temperature increased. Resistance to simulated gastrointestinal digestion was enhanced by spray drying. The application of a mild heat treatment before spray drying may enhance cell survival during storage and the resistance to gastrointestinal digestion. Spray drying might be used for enhancing cell functionality in a strain-dependant way.","palabras_clave":"."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87898,"idioma_id":4,"titulo":"GENOTYPIC AND PHENOTYPIC DETECTION OF CAPSULAR POLYSACCHARIDES IN STAPHYLOCOCCUS  AUREUS ISOLATED FROM BOVINE INTRAMAMMARY INFECTIONS IN ARGENTINA","resumen":"Staphylococcus aureus (n=157) isolated from intramammary infections in Argentine dairy areas wereevaluated for presence of cap5 and cap8 loci. Isolates carrying cap5 and cap8 were serotyped using specific antisera. Sixty four percent of the isolates were genotyped as cap5 or cap8 and 50% of them expressed CP5 or 8.(n=157) isolated from intramammary infections in Argentine dairy areas wereevaluated for presence of cap5 and cap8 loci. Isolates carrying cap5 and cap8 were serotyped using specific antisera. Sixty four percent of the isolates were genotyped as cap5 or cap8 and 50% of them expressed CP5 or 8.","palabras_clave":"STAPHYLOCOCCUS AUREUS|CAPSULAR POLYSACCHARIDE|BOVINE MASTITIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87899,"idioma_id":4,"titulo":"Exposure assessment of mycotoxins in cow?s milk in Argentina","resumen":"A stochastic simulation model was developed to carry out the first quantitative risk exposure assessment of the mycotoxin level in cow\u2019s milk produced in Argentina. The prevalence and concentration of aflatoxin M1 (AFM1), deoxynivalenol (DON) and zearalenone (ZEA) were modeled at various stages through milk processes complying with Argentinean practices. Concentration of AFM1 (0.059 ppb), DON (0.338 ppb) and ZEA (0.125 ppb) in dairy milk were estimated. The proportion of feed samples that exceeded the maximum level accepted by European regulations for AFB1, DON and ZEA were estimated at 25.07%, 0.0% and 8.9%, respectively. The percentage of milk samples that exceeded the maximum level accepted for AFB1 by the MERCOSUR (0.5 ppb) and the European Union regulations (0.05 ppb) were 0.81 and 32.65, respectively. The probability distribution of AFM1 concentration in milk was affected by the carry-over rate equations applied in the model. Mycotoxin levels in corn silage and concentrated feeds were the factors most correlated with mycotoxin concentrations in milk. Therefore, agricultural practices, crop management and feed production require prompt attention regarding mycotoxin issues.","palabras_clave":"Mycotoxins|Milk|Exposure-assessment|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87900,"idioma_id":4,"titulo":"The Neospora caninum-Spain 7 isolate induces placental damage, fetal death and abortion in cattle when inoculated in early gestation","resumen":"Abstract  The Nc-Spain 7 isolate of Neospora caninum, which was newly obtained from an asymptomatic congenitally infected calf, demonstrated a similar virulence as Nc-1 strain in mouse models. The aim of this study was to characterize the pathogenesis of Nc-Spain 7 isolate in cattle after experimental infection at 65 days of gestation. For this purpose, thirteen pregnant heifers were divided into three groups as follows: group A: 7 heifers inoculated with 1 × 10(8) tachyzoites of Nc-Spain 7 isolate; group B: 4 heifers inoculated with 1 × 10(8) tachyzoites of Nc 1 strain; and group C: 2 heifers received PBS. Serum samples were collected weekly and heparinized blood samples were collected three times (0, 28 and 42 days after inoculation) by jugular venipuncture. Placenta and fetal tissue samples were collected at time of necropsy. Specific antibody response in the dams was tested by IFAT, indirect ELISA, and rNcGRA7 and rNcSAG4 based-ELISA. Specific antibody response in fetal fluids was tested by IFAT. IFN-&#947; production was measured after in vitro culture of PBMC and the supernatant was assessed using a commercial kit (BOVIGAM). A significant increase in N. caninum antibody responses was detected in groups A and B by IFAT and by i-ELISA from day 14 after inoculation onwards. Besides, antibody response against rNCGra7 protein was also detected in all inoculated heifers by rNcGra7-based ELISA. Four fetuses from group A and one from group B were aborted between 3 and 5 weeks after infection. In the recovered fetuses, only 3 out of 4 fetal fluids from fetuses of group A and 1 out of 3 of group B were seropositive by IFAT, but all of them were positive by PCR. Transplacental transmission could be determined in all fetuses from groups A and B by PCR and\/or IHC. Heifers of group C and their fetuses remained negative by all techniques. The results of this study demonstrate that the NC-Spain 7 isolate could be transmitted transplacentally, and produced fetal death and abortion in cattle.","palabras_clave":"Experimental inoculation    |bovine neosporosis|fetopathy|Neospora caninum|Nc-Spain 7"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87901,"idioma_id":5,"titulo":"Trayectoria reciente y perspectivas futuras de la industria naval pesada argentina: los astilleros estatales","resumen":"Con un marco regulatorio de tipo proteccionista que buscaba promover la construcción de barcos en el país, la industria naval argentina se consolidó y expandió hasta los años 80 gracias a una fuerte intervención estatal, iniciada durante el proceso de Industrialización por Sustitución de Importaciones (ISI).  El presente trabajo se propone describir la historia reciente de este sector industrial, desde 1950 hasta la actualidad, centrando la atención en dos aspectos fundamentales. Por un lado, el rol central jugado por el estado (y su política industrial) como regulador, productor, cliente y agente de financiación de la industria naval y, por otro, la activa participación de los actores sociales, especialmente los trabajadores organizados, en la supervivencia productiva del sector en la década del 90. Para llevar adelante estos propósitos nos centramos en el estudio de los dos astilleros estatales, de construcción y reparación naval, más importantes del país: Astilleros Río Santiago (ARS) y Talleres Dársena Norte (Tandanor).  A modo de conclusión, reflexionamos sobre los principales desafíos y perspectiva futura del sector así como también sobre las responsabilidades que en el mismo le caben a los actores sociales más relevantes.","palabras_clave":"astlilleros publicos|estado|territorio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87902,"idioma_id":4,"titulo":"Experimental inoculation of Neospora caninum in pregnant water buffalo","resumen":"The aim of this study was to characterize the pathogenesis of&nbsp;Neospora caninum&nbsp;in experimentally inoculated pregnant water buffalo (Bubalus bubalis). Twelve Mediterranean female water buffaloes ranging in age from 4 to 14 years old and seronegative to&nbsp;N. caninum&nbsp;by indirect fluorescent antibody test (IFAT) were involved. Ten females were intravenously inoculated with 108&nbsp;tachyzoites of NC-1 strain at 70 (n&nbsp;=&nbsp;3) or 90 (n&nbsp;=&nbsp;7) days of pregnancy (dp). Two control animals were inoculated with placebo at 70 and 90&nbsp;dp, respectively. Serum samples were obtained weekly following inoculation to the end of the experiment. Three animals inoculated at 70&nbsp;dp were slaughtered at 28&nbsp;days post inoculation (dpi), three animals inoculated at 90&nbsp;dp were slaughtered at 28&nbsp;dpi and the remaining four animals inoculated at 90&nbsp;dp were slaughtered at 42&nbsp;dpi. Fetal fluids from cavities and tissue samples were recovered for IFAT and histopathology, immunohistochemistry and PCR, respectively. Genomic DNA from fetal tissues was used for parasite DNA detection and microsatellite genotyping in order to confirm the NC-1 specific-infection. Dams developed specific antibodies one week after the inoculation and serological titers did not decrease significantly to the end of the experiment. No abortions were recorded during the experimental time; however, one fetus from a dam inoculated at 70&nbsp;dp was not viable at necropsy. Specific antibodies were detected in only two fetuses from dams inoculated at 90&nbsp;dp that were slaughtered at 42&nbsp;dpi. No macroscopic changes in the placentas and organs of viable fetuses were observed. Nonsuppurative placentitis was a common microscopic observation in&nbsp;Neospora-inoculated specimens. Microscopic fetal lesions included nonsuppurative peribronchiolar interstitial pneumonia, epicarditis and myocarditis, interstitial nephritis, myositis and periportal hepatitis. Positive IHC results were obtained in two fetuses from dams inoculated at 70&nbsp;dp and slaughtered at 28&nbsp;dpi.&nbsp;N. caninum&nbsp;DNA was detected in placentas and fetuses from all inoculated animals. The pattern of amplified microsatellites from placental and fetal tissues resembled the NC-1 strain. Water buffaloes, like cattle, are susceptible to experimental inoculation with&nbsp;N. caninum&nbsp;at early pregnancy.","palabras_clave":"Neospora caninum|Fetal pathology|Water buffalo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87903,"idioma_id":5,"titulo":"Producción de una secuencia agrícola de 12 años fertilizada con fósforo y azufre, evaluación de los factores y beneficios económicos.","resumen":"-","palabras_clave":"Producción|Fertilización"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87904,"idioma_id":5,"titulo":"Respuesta de cultivares de trigo en secano campaña 2011\/2012 San Fabián-Departamento San Jerónimo-Santa Fe","resumen":"-","palabras_clave":"Trigo|Rendimiento"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87905,"idioma_id":5,"titulo":"Respuesta residual en trigo luego de 10 años de fertilización (2000-2009).","resumen":"-","palabras_clave":"Residualidad|Trigo|Fertilización"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87906,"idioma_id":4,"titulo":"Babesia bovis biological clones and the inter-strain allelic diversity of the Bv80 gene support subpopulation selection as a mechanism involved in the attenuation of two virulent isolates","resumen":"The virulence phenotype of Babesia bovis subpopulations was evaluated using biological clones derived from the high-virulence BboS2P and the low-virulence BboR1A strain and two original virulent isolates, BboL15 and BboL17, multiplied extensively in vitro or attenuated by successive passages in splenectomized calves. The virulence phenotype was assessed both by inoculation of normal Holstein adult steers and by analyses of polymorphic fragments of the single-copy Bv80 gene as a subpopulation marker. BboS2P and its nine derived clones contained a single 750 bp fragment with identical nucleotide sequences and numbers of repeats. A single fragment of approximately 850 bp was observed in BboR1A and its derived clones (Ca3B1, Ca2B1). Ca3B1 and Ca2B1 were differentiated by a stable deletion of 15 contiguous nucleotides in the Bv80 allele of Ca3B1. Both alleles were identified in the parental strain. Original isolates BboL15 and BboL17 contained two Bv80 fragments of different sizes. Interestingly, the heavy and light fragments persisted in the in vivo-attenuated strains and the virulent in vitro-multiplied strains, respectively. Despite the inter-strain allelic diversity of the Bv80 gene, the fragments had identical nucleotide sequences and numbers of repeats compared to their respective parental Bv80 genes. The high-virulence and low-virulence phenotypes remained unchanged after they were multiplied in vitro. In conclusion, the polymorphic B. bovis Bv80 gene, was a useful marker for differentiating subpopulations with different phenotypes. The brevity of the procedure to isolate one parasite from the original isolate or strain before in vitro cloning and the fact that the continuous in vitro multiplication did not modify the virulence phenotype of B. bovis clones strongly suggest that the in vivo-attenuated subpopulations existed in the original isolates before they were selected by passages in splenectomized calves.","palabras_clave":"Babesia bovis|Biological clones|Virulence attenuation|Bv80"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87907,"idioma_id":5,"titulo":"PRODUCTIVIDAD DEL MAÍZ Y DEL SORGO EN DISTINTAS SECUENCIAS DE CULTIVOS ANUALES PARA EL CENTRO DE SANTA FE","resumen":"El objetivo del trabajo fue evaluar la productividad de algunas alternativas de doble-cultivo con maíz y sorgo, &nbsp;en comparación con su siembra como cultivo único anual y considerar las implicancias prácticas del mismo para el centro de Santa Fe.","palabras_clave":"MAIZ|SORGO|SECUENCIAS AGRÍCOLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87908,"idioma_id":5,"titulo":"Rotaciones agrícolo-ganaderas para el centro de Santa Fe: respuesta de algunos parámetros de fertilidad del suelo","resumen":"Rotaciones agrícolo-ganaderas para el centro de Santa Fe: respuesta de algunos parámetros de fertilidad del suelo","palabras_clave":"ROTACION |FERTILIDAD|SUELO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87909,"idioma_id":5,"titulo":"Respuesta del sorgo granífero a la población de plantas, según el ciclo de madurez en dos fechas de siembra en la región centro-oeste de Santa Fe","resumen":"La región central santafesina presenta una variabilidad climática y de suelos que permite la actividad agrícola, preferentemente integrada a los sistemas mixtos de producción basados fundamentalmente, en la ganadería lechera y\/o de invernada. En ese contexto, el sorgo granífero tiene un rol fundamental, debido a su capacidad de generar rendimientos con escasa oferta hídrica, a su adaptación a los suelos de menor aptitud agrícola y por constituir una fuente forrajera adecuada para los sistemas ganaderos de la región. Si bien el sorgo granífero puede compensar entre un amplio rango de densidades, el óptimo depende de la oferta ambiental, de la fecha de siembra y de la precocidad del material, entre otros (Villar, 1988). Cualquiera de los factores que reducen la longitud del ciclo de desarrollo y la capacidad de interceptar la radiación, como retrasos en la fecha de siembra o uso de cultivares precoces, exigen aumentar la población de plantas para compensar sus efectos negativos sobre el crecimiento y los rendimientos de grano (Villar, 1994).&nbsp;El objetivo del trabajo fue ajustar la densidad de plantas a lograr con cultivares de sorgo granífero contrastantes en ciclo para dos fechas de siembra en la región centro-oeste de Santa Fe.Se destaca el mayor potencial de las siembras tempranas con híbridos de ciclo completo. En siembras tardías de enero, es recomendable el uso de materiales más precoces. Adicionalmente, se observó una tendencia a mejorar los rendimientos con densidades de 22,5 plantas\/m2, independientemente del ciclo de madurez e incluso, con poblaciones superiores para los más precoces de bajo porte, aunque ello debe ser corroborado con experiencias complementarias.","palabras_clave":"SORGO GRANÍFERO|FECHA DE SIEMBRA|DENSIDAD|RENDIMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87910,"idioma_id":5,"titulo":"Análisis comparativo del crecimiento y productividad del trigo y de la colza en el centro-oeste santafesino","resumen":"El cultivo de colza (Brassica napus L.) está siendo incorporado en algunos de los esquemas de rotación en varias regiones del país, principalmente en la provincia de Bs. As. Se presenta como otra de las alternativas frente al tradicional cultivo de trigo, con algunas ventajas sobre éste. Al respecto, se han mencionado como una de las principales, la liberación más temprana del lote que permite una mejor fecha de siembra de la soja de segunda (Renison, 2005). Además, podrían hacerse períodos de barbecho mayores, no solo importante para las rotaciones con soja, sino que se adapta a una amplia gama de cultivos, si el manejo agronómico es el correcto (Villar, 2008).Con el objetivo de realizar un análisis comparativo entre ambos cultivos, evaluando el crecimiento, la productividad y la dinámica hídrica, y a fin de aportar información de interés para la región centro de Santa Fe, se realizó un experimento a campo en el INTA Rafaela (31°12\u2019 LS, 61°30\u2019 LO, 99 msnm), durante la campaña 2011\/12. La colza permitió anticipar la cosecha con respecto al trigo en 28 días para el híbrido Hyola 76 y en 11 días para la variedad Pachá. Cabe recordar que la cosecha de trigo se efectuó una vez alanzada la madurez fisiológica, por lo que es de esperar que, en situaciones normales de cosecha, las diferencias se incrementen en aproximadamente 15 días.La colza rindió en grano el 52% de lo que rindió el trigo, valor similar al 55% reportado por Iriarte y Valetti (2002), pero en términos energéticos los rendimientos fueron similares. Si se compara el precio del trigo a futuro en enero 2013, que ronda los 158 dólares la tonelada, mientras que el de la colza es de 450 dólares, y con los rendimientos obtenidos, se conseguiría un ingreso bruto por la venta del grano de 785 dólares\/ha para el trigo y 1172 dólares\/ha, para la colza, lo que adquiere particular relevancia porque los costos de producción son similares.La colza se presenta, entonces, como una muy buena opción al momento de decidir un cultivo alternativo al trigo, o bien para diversificar la producción y los riesgos.","palabras_clave":"COLZA|TRIGO|PRODUCTIVIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87911,"idioma_id":4,"titulo":"Histopathology of the resistance to Colletotrichum gloeosporioides of wild strawberries and species related to commercial strawberry","resumen":"Three species of wild strawberries, as well as three related species, were tested against virulent isolate of Colletotrichum gloeosporioides. The purpose of this study was to assess genetic resources exhibiting resistance to anthracnose. The results of inoculation experiments showed that the species Fragaria vesca, Fragaria virginiana and Fragaria chiloensis were susceptible to fungi; whereas species Duchesnea indica, Duchesnea chrysantha and Potentilla tucumanensis showed higher levels of resistance. A histopathological study revealed a different response between susceptible and tolerant species. A significant thickening of the cell wall in epidermal cells, changes of stomata and mesophyll cells, the presence of idioblastic cells with unknown content and the accumulation of large starch grains in atypical tissues, namely, stomata and parenchyma cells, were observed in species of the genus Duchesnea. However, no morphological alteration was observed in Fragaria species or in P. tucumanensis, which did not show any apparent interaction with the isolate of C. gloeosporioides. Oxidative burst was evaluated in leaf tissues with the fluorescent probe DCFH-DA (2\u2019,7\u2019-Dichlorofluorescein diacetate) in susceptible and tolerant genotypes. Results showed that tolerant species present a noticeable accumulation of H2O2 whereas susceptible species did not. These results have led us to the conclusion that the changes observed were correlated with the resistance to disease.","palabras_clave":"DUCHESNEA INDICA|POTENTILLA TUCUMANENSIS|FRAGARIA VESCA|ANTHRACNOSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87912,"idioma_id":5,"titulo":"Cultivares de frutilla adecuadas al uso de residuos de cosecha de caña de azúcar como acolchado alternativo al plástico","resumen":"Se evaluó la adaptabilidad de diferentes cultivares de frutilla (Fragaria ananassa Duch.) al uso de \u201Cmaloja\u201D de caña de azúcar (Saccharum officinarum L.) como alternativa al acolchado plástico, en EEA INTA Famaillá, Tucumán, Argentina, año 2008. El diseño experimental fue completamente aleatorizado con tres repeticiones y arreglo en parcela dividida, evaluándose cultivares de día corto (Camarosa y Sabrosa) y de día neutro (Aromas y Albion), sobre acolchados vegetal, de un 1 cm de espesor aproximadamente, y plástico negro de 25 mm de espesor. Al inicio del ciclo, el contenido de humedad del suelo se mantuvo dentro del rango de agua fácilmente utilizable en ambos tipos de acolchado, aunque fue mayor bajo el plástico. La entrada en producción en acolchado vegetal se retrasó con respecto al plástico, pero se extendió a fin de ciclo. Durante meses con temperatura promedio diaria menor a 20 °C, todas las cultivares tuvieron mayor rendimiento en acolchado plástico, siendo más evidentes las diferencias en cultivares de día corto. Durante meses con temperatura promedio diaria mayor a 20 °C, no se observaron diferencias significativas entre tipo de acolchado, con tendencias de mayor rendimiento en acolchado vegetal para cultivares de día neutro. Se destaca la importancia de la elección de la cultivar según el tipo de acolchado.","palabras_clave":"MULCH ORGÁNICO|MALOJA|FRAGARIA ANANASSA DUCH.|AGRICULTURA SUSTENTABLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87913,"idioma_id":4,"titulo":"Fruit yield of strawberry plants inoculated with Azospirillum brasilense RLC1 and REC3 under field conditions","resumen":"The beneficial effect of inoculating with Azospirillum brasilense on crop productivity has been widely described in different crops, but its extensive use in strawberry typical agricultural field environments is scarcely documented. The objective of this study was to quantify the fruit yield of strawberry plants (Fragaria ananassa Duch.) inoculated with A. brasilense (strains RLC1 and REC3) under typical dryland farming conditions. The study was performed during 2006-2009 growing seasons, evaluating root inoculated and non-inoculated strawberry plants cultivar 'Camarosa' in Tucumán, Argentina. The inoculated plants exhibited more vigorous vegetative growth and increased the total fruit yield by 8.5% and marketable yield by 7%, as compared with non-inoculated plants.","palabras_clave":"Azospirillum brasilense|Fragaria ananassa|plant growth-promoting bacteria|inoculation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87914,"idioma_id":5,"titulo":"Estudio del efecto promotor de Azospirillum brasilense en plantas de frutilla (Fragaria ananassa Duch.) cv. \u2018Camarosa\u2019 en condiciones de campo","resumen":"Las bacterias del género Azospirillum pertenecen al grupo de bacterias denominadas PGPB (del inglés \u201CPlant Growth Promoting Bacteria\u201D) capaces de promover el crecimiento de numerosos cultivos de interés agronómico, entre ellos la frutilla. Para verificar el efecto promotor de crecimiento ejercido por A. brasilense en un cultivo comercial de frutilla, con un bajo aporte de fertilización nitrogenada y sin la misma, se inocularon plantas del cv. \u201ECamarosa&#8223; con la cepa PEC 5. El ensayo tuvo lugar en la Estación Experimental de INTA Famaillá durante la campaña 2009. Se verificó lacolonización de A. brasilense en las raíces de plantas de frutilla determinándose el Número Más Probable (NMP) al inicio y final de campaña. Además, se pudo reaislar A. brasilense a partir de plantas inoculadas y no así de plantas controles. A lo largo del ensayo se realizó el estudio morfofisiológico de las plantas, obteniéndose principalmente en las extracciones de agosto un mayor peso y número de hojas, coronas e inflorescencias en plantas inoculadas con respecto a plantas no inoculadas (ambas sin fertilización nitrogenada). Observándose mayor área foliar en las plantas inoculadas con respecto a las plantas sin inocular. Si bien no se vio un mayor índice de verdor (IV) en hojas de plantas inoculadas se pudo observar, mayor contenido de nitrógeno en muestras de hojas y de raíces de las plantas inoculadas con respecto a las controles. Lográndose mayores rendimientos en frutos de calidad comercial durante la producción primicia en plantas inoculadas con respecto a las plantas controles (ambas sin fertilización nitrogenada). En cambio, en los lotes fertilizados con una baja dosis de nitrógeno, se obtuvieron mayores rendimientos en frutos de calidad comercial durante la etapa de producción temprana y de estación en plantas inoculadas con respecto a sus controles. De acuerdo a los resultados obtenidos, el manejo del cultivo de frutilla planteado con el uso de este tipo de bacterias promotoras del crecimiento vegetal, ya sea sustituyendo parcial o totalmente la fertilización nitrogenada, genera un aumento en el rendimiento de fruta comercial, disminución en el costo de producción de frutilla por la disminución en el uso de fertilizantes de síntesis química, mayor ingreso de dinero, y contribuye con el desarrollo de un sistema de producción sostenible de frutilla, haciéndola más amigable con la salud humana y el ambiente.","palabras_clave":"FRUTILLA|AZOSPIRILLUM|PGPB|INOCULANTE BACTERIANO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87915,"idioma_id":4,"titulo":"Foliar diseases on tea and maté in Argentina caused by Pseudocercospora species","resumen":"The leaf-spotting hyphomycete Pseudocercospora theae on tea (Camellia sinensis) is described from the Province Misiones in Argentina. This is the first record of this disease from Argentina. The taxonomy of Pseudocercospora species on Camellia spp. is briefly discussed, and the species concerned are keyed out. Pseudocercospora mate is an endemic cercosporoid hyphomycete on maté (yerba mate, Ilex paraguariensis) described from Argentina. This little known species is re-described on the base of new rich specimens recently collected in Misiones. The taxonomy of this species is discussed, above all the differentiation between P. mate and confused Asian collections that belong to P. naitoi. A key to Pseudocercospora species on Ilex spp. is provided.","palabras_clave":"Cercosporoid hyphomycetes|Misiones|Pseudocercospora mate|Pseudocercospora theae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87916,"idioma_id":5,"titulo":"3° Ciclo de Conferencias Técnicas en Avicultura 2012, Módulo Salud de las aves I","resumen":"Las disertaciones versaron sobre 'Salud intestinal en avicultura' y 'Enfermedades inmunosupresoras en las aves comerciales'.La eficiencia de asimilación de nutrientes tiene una alta correlación con la superficie funcional de la mucosa instestinal. La respuesta inflamatoria intestinal tiene un impacto directo en la asimilación de los alimentos.Las mayores demandas del mercado internacional y nacional de carne de ave hace que las aves comerciales actuales se encuentren bajo grandes exigencias productivas y sanitarias.","palabras_clave":"AVICULTURA|SALUD|AVES|ENFERMEDADES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87917,"idioma_id":4,"titulo":"Glacial paradoxes during the late Paleozoic ice age: Evaluating the equilibrium line altitude as a control on glaciation","resumen":"The late Paleozoic ice age (LPIA) consists of multiple glaciations that   waxed and waned across Gondwana during the Carboniferous and Permian.   Three key intervals are evaluated using the concept of the   equilibrium-line altitude (ELA) as a control on glaciation to provide   insight into two intervals of paradoxical ice distribution during and   following glaciation. The LPIA began in the mid-latitudes during the   Viséan in western Argentina with the growth of glaciers in the   Protoprecordillera. Glaciation was initiated by uplift of the range   above the ELA. In the Bashkirian, deglaciation occurred there while   glaciation was beginning at the same latitude in uplands associated with   the Paraná Basin in Brazil. Analysis suggests that deglaciation of the   Protoprecordillera occurred due to extensional collapse of the range   below the ELA during a westward shift in the location of plate   subduction. During Late Pennsylvanian\u2013Early Permian peak glaciation for   the LPIA, extensive glacimarine deposits indicate that glaciers reached   sea level, which corresponds to a major lowering of the ELA due to   global cooling. Finally, during the Early to early Late transition out   of the LPIA, polar Gondwana was unglaciated. However, three glacial   intervals occurred at mid- to high-latitudes in eastern Australia from   the Sakmarian to the Capitanian\/earliest Wuchiapingian. The magnitude of   global cooling during these events is debatable as evidence indicates   ice-free conditions and an elevated ELA at the South Pole in Antarctica.   This suggests that severe global cooling was not the cause of the final   three Australian glaciations, but rather that ELA-related conditions   specific to eastern Australia drove these late-phase events. Possible   causes for the Australian glaciations include: 1) anomalous cold   conditions produced by coastal upwelling, 2) the presence of uplands   allowing nucleation of glaciers, 3) fluctuations in pCO2 levels, and 4) increased precipitation due to the location of the area in the subpolar low pressure belt.","palabras_clave":"Late Paleozoic ice age|Gondwana glaciation|Equilibrium line altitude|Carboniferous|Permian|Paleoclimate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87918,"idioma_id":4,"titulo":"Beneficial effects of Neotyphodium tembladerae and Neotyphodium pampeanum on a wild forage grass","resumen":"Asexual, vertically transmitted fungal endophytes in  genus Neotyphodium are considered to enhance growth,  stress resistance and competitiveness of agronomic  grasses, but have been suggested to have neutral or  deleterious effects on wild grasses. We studied whether  the associations between Bromus auleticus and their  endophytes, Neotyphodiumpampeanum and Neotyphodium  tembladerae, are beneficial for this wild forage grass native  to South America. In a greenhouse experiment,  3-month-old endophyte-infected plants (E+) showed  enhanced growth relative to their endophyte-free counterparts  (E)). In a one-year-long experiment in the field,  E+ plants showed higher survival and regrowth rate, and  produced more biomass and seeds than E) plants. Only  with respect to the seed output did N. tembladerae seems  to be detrimental, whereas N. pampeanum did not affect  this parameter. No differences were observed with  respect to the germination of seeds produced by E+ or  E) plants. Loline alkaloids were detected in N. pampeanum-  infected plants. Our results show that, similar with  results on agronomic grasses, in wild grasses, the symbiosis  with Neotyphodium species could be mutualistic.","palabras_clave":"ENDOPHYTES|BROMUS-AULETICUS|GROWTH|BIOMASS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87919,"idioma_id":4,"titulo":"Bovine Leukemia Virus p24 antibodies reflect blood proviral load","resumen":"Abstract    Background  Bovine leukemia virus (BLV) is worldwide distributed and highly endemic in Argentina. Among the strategies to prevent BLV dissemination, a control plan based on the selective segregation of animals according to their proviral load (PVL) is promising for our dairy productive system. The objective of this work was to study the relationship between the blood PVL and the antibody level, in order to identify whether the individual humoral response, i.e. the anti-p24 or anti-whole-BLV particle, could be used as a marker of the blood level of infection and thus help to recruit animals that may pose a lower risk of dissemination under natural conditions.    Results  The prevalence of p24 antibodies on the 15 farms studied was over 66%. The prevalence of p24 and whole-BLV antibodies and PVL quantification were analyzed in all the samples (n&#8201;=&#8201;196) taken from herds T1 and 51. ROC analysis showed a higher AUC for p24 antibodies than whole-BLV antibodies (Zreactivity: 3.55, P&#8201;<&#8201;0.001; Ztiter: 2.88, P&#8201;<&#8201;0.01), and as consequence a better performance to predict the proviral load status in herd 51. No significant differences were found between the performance of p24 and whole-BLV antibodies in herd T1. A significant positive correlation was observed between PVL values and p24 antibody reactivity in both farms (r T1&#8201;=&#8201;0.7, P&#8201;<&#8201;0.001, r 51&#8201;=&#8201;0.71, P&#8201;<&#8201;0.0001). The analysis was extended to the whole number of weak p24 antibody reactors (n&#8201;=&#8201;311) of the other 13 farms. The mean of high PVL reactors within weak p24 reactors was 17.38% (SD&#8201;=&#8201;8.92). In 5\/15 farms, the number of weak p24 reactors with high PVL was lower than 10%. Conclusions  We found that the humoral response reflected the level of in vivo infection, and may therefore have useful epidemiological applications. Whereas the quantitative evaluation of blood proviral load using real-time PCR is expensive and technically demanding, the measurement of antibodies in blood by ELISA is relatively straightforward and could therefore constitute a cost-effective tool in a BLV control intervention strategy, especially in highly infected herds such as Argentinean dairy ones.","palabras_clave":"BLV|PROVIRAL LOAD|CONTROL MEASURES|SEROLOGICAL MARKER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87920,"idioma_id":5,"titulo":"Crecimiento de cuatro familias de Pinus taeda en respuesta a la fertilizacion con nitrógeno y fósforo en el establecimiento de la plantación","resumen":"Los individuos de Pinus taeda utilizados en plantaciones comerciales sobre suelos lateríticos de Argentina, presentan heterogeneidad en la respuesta a la fertilización con nitrógeno (N) y fósforo (P) durante el establecimiento. En general, las respuestas en crecimiento a la aplicación de P son positivas, mientras que la aplicación de N en forma de urea tiene un efecto perjudicial. El objetivo de este trabajo fue evaluar la respuesta a la fertilización con N y P de cuatro familias de P. taeda seleccionadas de un plan de mejoramiento genético, y determinar si la mejora genética permite obtener materiales con diferente respuesta a la adición de estos nutrientes. Los resultados demuestran que existe variabilidad entre las familias en el crecimiento en altura y diámetro del cuello, 8 y 16 meses luego de realizada la fertilización. Las familias de mayor tasa de crecimiento, respondieron positivamente a fertilización con P y no fueron afectadas por la fertilización con N. La familia que tuvo un crecimiento intermedio, no respondió a la adición de P y fue negativamente afectada por el N. La familia de menor crecimiento, respondió positivamente frente a la fertilización con P, pero fue negativamente afectada por el N. La mejora genética permite obtener genotipos con altas tasas de crecimiento que respondan en mayor magnitud a la fertilización con P y que no sean negativamente afectados por la adición de nitrógeno. Mediante el mejoramiento genético se puede evitar la penalidad en crecimiento que implica fertilizar con urea en el establecimiento, factor que facilitaría la utilización de esta práctica silvícola para recuperar o mantener la dotación de N de los sitios que están sujetos a repetidos ciclos de plantación y cosecha.","palabras_clave":"EFECTO DEPRESIVO|CRECIMIENTO INICIAL|UREA|SUPER FOSFATO TRIPLE|MEJORAMIENTO GENETICO|INTERACCION GENOTIPO FERTILIZACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87921,"idioma_id":4,"titulo":"Seasonal variation in sexual behavior, plasma testosterone and semen characteristics of Argentine Pampinta and Corriedale rams","resumen":"Five Argentine Pampinta (dairy breed) and six Corriedale (dual-purpose breed) adult rams were used to study the effect of season on sexual behavior, plasma testosterone (T) and semen characteristics for a period of 1 year. Scrotal circumference (SC) and T concentrations were determined at 2-week intervals. Each ram was exposed monthly to three ovariectomized ewes in one 20-min test and the total number of mounts and successful matings were recorded. Semen collection was attempted from each ram twice weekly for six consecutive weeks during each season. In both breeds, SC varied seasonally showing the lowest mean values during winter and spring and in the Corriedale rams (32.8 ± 0.3 cm) was smaller (p &lt; 0.05) than in Pampinta rams (34.4 ± 0.4 cm). No difference (p &gt; 0.05) was recorded in T concentra-tion between breeds and both breeds reached a peak in summer and autumn. Number of matings showed the maximal values in autumn in both breeds. Season had no significant effect on mass motility, sperm concentration and percentage of live sperm. Semen volume, percentage of progressive motility and total sperm per ejaculate were higher during summer and autumn than in other seasons of the year. Pampinta rams had the highest values (p &lt; 0.05) of sperm con-centration, total sperm per ejaculate and percentage of abnormal sperm. Results of this study show that sexual behav-ior, SC and T concentrations exhibit seasonal variation in Pampinta and Corriedale rams and that semen of superior quantity and quality is especially collected in both breeds during the summer and autumn.","palabras_clave":"hormone, rams; ; |semen quality|serving capacity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87922,"idioma_id":5,"titulo":"Efecto de triticale (x Triticosecale Wittmack) rolado como cultivo de cobertura en la supresión de malezas, rendimiento y margen bruto de soja","resumen":"NO TIENE","palabras_clave":"AGUA|RESIDUOS|SUSTENTABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87923,"idioma_id":5,"titulo":"EFECTO DE VICIA VILLOSA COMO CULTIVO ANTECESOR Y LA FERTILIZACION NITROGENADA SOBRE LA PRODUCCION DEL CULTIVO DE MAIZ","resumen":"El objetivo del trabajo fue evaluar el efecto de vicia villosa como antecesor de maíz con diferentes dosis de fertilizante posterior a la siembra.","palabras_clave":"AGUA UTIL|MINERALIZACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87924,"idioma_id":4,"titulo":"Species within the Bemisia tabaci (Hemiptera: Aleyrodidae) complex in soybean and bean crops in Argentina","resumen":"The whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is a cryptic species complex that contains some of the most damaging pests in tropical and subtropical regions. Recent studies suggested that this complex is composed of at least 24 distinct species. We use the approach from these studies to consider the identity of B. tabaci in Argentina. Previous studies have suggested the presence of a B. tabaci presumably indigenous to the Americas and referred to as the BR biotype in Argentina. We placed the entity referred to as the BR biotype within the B. tabaci cryptic species complex using whiteflies collected in soybean and bean crops in northern and central Argentina. The whiteflies were assigned using the mitochondrial cytochrome oxidase (mtCOI) gene. Four unknown haplotypes plus two Argentina sequences from GenBank formed a cluster that was basal to the rest of the New World sequences. These sequences diverged from the consensus sequence across the range of 3.6 to 4.3%. Applying the species assignment rules of recent studies suggests that the individuals from Argentina form a separate species. A fifth unknown haplotype fell within the New World putative species and formed a distinct cluster with haplotypes from Panama. These results suggest that Argentina has two indigenous species belonging to the B. tabaci cryptic species complex. Rather than using mtCOI sequencing for all B. tabaci collected, a simple random amplified polymorphic DNA-polymerase chain reaction diagnostic was used and tested along with previously published primers designed to work specifically with the BR biotype from Brazil. These primers were either unable to distinguish between the two indigenous members of the complex in Argentina or indicated a difference when none was evident on the basis of mtCOI sequence comparison.","palabras_clave":"WHITEFLY|MITOCHONDRIAL CYTOCHROME OXIDASE I|PHYLOGENETIC ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87925,"idioma_id":4,"titulo":"Incidence of begomoviruses and climatic characterisation of Bemisia tabaci-geminivirus complex in soybean and bean in Argentina","resumen":"Since the 1990s geminiviruses have emerged as devastating pathogens in tropical and subtropical regions as well as in temperate regions. Recent studies accomplished molecular hybridization-based detection of three begomoviruses infecting soybean and bean crops in Argentina, Bean golden mosaic virus (BGMV), Soybean blistering mosaic virus (SbBMV) and Tomato yellow spot virus (ToYSV). The aims of the present study were to determine incidence and prevalence of the three known geminiviruses in soybean and bean crops in Argentina following the same procedure and to characterize the sites where Bemisia tabaci-geminivirus complex was found based on climate data. The highest incidence values were observed in Salta province. BGMV exhibited the highest prevalence and incidence values in the bean crop, followed by SbBMV. In the soybean crop, SbBMV showed the highest prevalence and incidence values, followed by ToYSV. One hundred and three soybean and bean plots distributed in Argentina, where the Bemisia tabaci-geminivirus complex was detected, were characterized employing a Geographic Information System (GIS). The complex was found in warm and low rainfall areas; these climatic characteristics are consistent with those identified in a previously described model. A map with the probability of occurrence of B. tabaci-geminivirus, based on the climatic characteristics, was obtained.","palabras_clave":"begomoviruses|Bean golden mosaic virus|Geographic Information System (GIS)|Tomato yellow spot virus|Soybean blistering mosaic virus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87926,"idioma_id":5,"titulo":"Uso y creación de simulaciones en la formación del profesorado: unidad didáctica sobre el movimiento oscilatorio armónico","resumen":"En es este artículo se presenta una experiencia didáctica sobre el tema movimiento oscilatorio armónico llevada a cabo con un número reducido de estudiantes futuros profesores de física, donde se plantea una secuencia de enseñanza que articula: experimentos, simulaciones y simulaciones realizadas por los estudiantes. La secuencia de enseñanza se complementa con una propuesta de seguimiento y evaluación coherente al modelo de enseñanza - aprendizaje que se quiere hacer vivenciar a los alumnos futuros docentes. En ella se estimula la reflexión permanente sobre el propio aprendizaje. Se describen los resultados, fundamentalmente de carácter cualitativo y se comparten algunos de tipo cuantitativo a modo de referencia. Los resultados muestran una evolución positiva en aspectos conceptuales, procedimentales y actitudinales. Se destaca el desarrollo e identificación de procesos metacognitivos puestos en juego.","palabras_clave":"FORMACIÓN PROFESORES|SIMULACIONES|MOVIMIENTO OSCILATORIO|METACOGNICION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87927,"idioma_id":4,"titulo":"Highbush blueberry blight caused by a member of the Fusarium incarnatum-F. equiseti species complex in Buenos Aires province, Argentina","resumen":"Blueberry","palabras_clave":"PLANT DISEASES|FRUIT CROPS|PLANT PATHOGENS|VACCINIUM CORYMBOSUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87928,"idioma_id":-1,"titulo":"Remediation of feedlot effluents with a high organic load using aquatic plants","resumen":"Feedlots have increased in several regions of Argentina, particularly in the Pampas. The absence of adequate treatments of the effluents produced in these establishments creates serious problems to the society. Phytoremediation can be defined as inexpensive and environmentally sustainable strategy used to remove pollutants by plants. The aim of this study was to evaluate the remediation potential of two macrophyte species (Eichhornia crassipes and Hydrocotyle ranunculoides) on a feedlot effluent. This effluent was treated with these species for 31 days. Control and macrophyte treatments decreased dissolved inorganic nitrogen (DIN), Kjeldahl nitrogen (Kj N), biological oxygen demand (BOD), chemical oxygen demand (COD), total dissolved salts (TDS), total phosphorus (TP), Pb, Zn and Cr levels. At macrophyte treatments, relatively constant pH levels were kept and decreased EC and TDS values were obtained compared to control, mitigating the release of contaminants and potential greenhouse gases to the atmosphere. Moreover, significant increases in biomass were obtained, being higher in E. crassipes. The results allow concluding that the presence of aquatic plants increases the removal rates of nutrients, organic matter and heavy metals from wastewater in approximately 10-17 days for a feedlot effluent with high organic load.","palabras_clave":"intensive livestock systems  |pollution |effluent|phytoremediation macrophytes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87929,"idioma_id":5,"titulo":"INCLUSION DE VICIA VILLOSA PARA INCREMENTAR EL RENDIMIENTO DEL CULTIVO DE MAIZ","resumen":"El objetivo del trabajo fue evaluar el efecto de dos antecesores diferentes, barbecho y vicia como cultivo de cobertura en la dinámica del nitrógeno y el rendimiento del cultivo de maíz, con diferentes dosis de fertilización nitrogenada.","palabras_clave":"HAPLUSTOL|NITROGENO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87930,"idioma_id":5,"titulo":"Acerca de la extensión rural en contextos de emergencias ambientales","resumen":"El presente artículo sintetiza la experiencia llevada a cabo en el marco del Proyecto de Acción Inmediata, Universidad Nacional de Río Negro 2011: ?Asociativismo, crisis y emergencia: una estrategia colectiva.? El proyecto estuvo destinado a pequeños productores ganadero-ovinos de la zona rural de las localidades de Valcheta, Los Menucos, Ramos Mexía y Maquinchao, a las familias de los productores, organizaciones de productores y otras instituciones vinculadas al desarrollo rural de la Línea Sur. Fue llevado a cabo por profesionales y alumnos de la Carrera de Medicina Veterinaria de la U.N.R.N., sede Valle Medio, Choele Choel. El objetivo fue contribuir a generar y fortalecer estrategias colectivas asociadas entre los productores de las zonas rurales mencionadas, para enfrentar las consecuencias socioeconómicas y productivas originadas por la erupción del volcán Puyehue, el 4 de junio de 2011.  En el transcurso del trabajo se combinaron estrategias de recolección de datos cuantitativas (encuesta) y cualitativas (entrevista semiestructurada). Se entrevistaron referentes de tres organizaciones de carácter no reivindicativo, una de carácter reivindicativo y una en proceso de formación, y posteriormente, los datos fueron abordados desde una óptica interpretativa. En cuanto a los resultados del proyecto,, puede afirmarse que del diagnóstico realizado surgió la necesidad de contribuir a superar el grado de fragmentación de los pequeños productores y de responder a las problemáticas planteadas con equipos de trabajo interdisciplinarios, razón por la que se planificó un Programa de Jornadas para el período 2012-2013. Asimismo pudo concluirse que la erupción del Puyehue no actuó como ?disparador? del surgimiento de ninguna de las organizaciones abordadas, sino que acrecentaron las dificultades compartidas anteriores a este fenómeno, vinculadas con la escasez de agua y la comercialización de la lana. A pesar del grado de fragmentación que se observó entre los pequeños productores -no así entre los medianos-, hubo coincidencia con respecto a que el problema más acuciante y estructural de la región es la escasez de agua, agravada por la continua llegada de cenizas que han agudizado el debilitamiento y muerte del ganado; la baja en la calidad de la lana y el descenso del precio de venta; el envejecimiento prematuro de las majadas y el incremento de la pérdida de hembras y corderos.","palabras_clave":"extensionismo rural|productores ganaderos|asociativismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87931,"idioma_id":5,"titulo":"Aspectos diferenciales de la inteligencia cultural. Un abordaje en estudiantes militares argentinos","resumen":"Estudios actuales abordan el modo en que los militares desarrollan operaciones adaptándose a culturas diversas, desplegando contextual y situacionalmente un dominio multidimensional conocido como inteligencia cultural. Bajo estas premisas, se desarrolló un estudio cuantitativo con el objetivo de indagar el comportamiento de dicho constructo considerando variables tales como la región geográfica de procedencia, la presencia de lazos de parentesco multicultural, de estadías en diferentes naciones, y las diferencias dimensionales de la inteligencia cultural de acuerdo al año de cursada de estudiantes militares argentinos residentes en el Colegio Militar de la Nación (instituto universitario de formación de oficiales del Ejército Argentino).  Los resultados indican que la inteligencia cultural cognitiva diferencia significativamente a los estudiantes conforme a su lugar de procedencia, sobre todo a aquellos de origen extranjero, los que presentan un gran caudal de conocimientos culturales. Contrariamente, la posesión o ausencia de lazos de parentesco multiculturales no ha implicado diferencias en las puntuaciones generales y dimensionales de la inteligencia cultural.   Por otro lado, existen diferencias en los niveles de inteligencia cultural de los cadetes de acuerdo hayan vivido experiencias culturales turísticas a través de viajes; particularmente, existen diferencias muy significativas en su reflexión y motivación por vincularse con personas de culturas diferentes durante sus estancias.  Por último, las conductas y aspectos lingüísticos culturales muestran cierta precariedad durante el ciclo de formación académica de los estudiantes militares, lo que evidencia la necesidad de profundizar y sistematizar procesos de aprendizaje de idioma y comunicación junto al entrenamiento local y transcultural de tales dominios.","palabras_clave":"Inteligencia|Cultural|Estudiantes|Militares"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87932,"idioma_id":5,"titulo":"Talleres de Adultos Mayores: Un aporte para el envejecimiento activo","resumen":"En todo el mundo se asiste a una revolución silenciosa, en la cual el protagonista es el adulto mayor; el cambio poblacional apunta a considerarlo como un problema socioeconómico trascendente del siglo XXI. Y el envejecimiento activo se perfila como un arma estratégica para enfrentar la problemática planteada. El objetivo del presente trabajo es presentar los distintos talleres para adultos mayores que se dictan en la Universidad Nacional de Quilmes, su origen, su funcionamiento y los propósitos a los que se aspira en cada uno de ellos. Se intenta contribuir a que el adulto mayor mejore su calidad de vida, revalorizar a la persona mayor y aceptar positivamente el hecho de hacernos mayores, facilitarle el acceso a los recursos culturales de su entorno, reconocer el capital humano de la persona mayor y considerarlo como un agente socialmente activo. Envejecer es un éxito personal y colectivo, y más si se envejece activamente y participando plenamente en la sociedad.","palabras_clave":"Talleres para adultos mayores|envejecimiento|envejecimiento activo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87933,"idioma_id":5,"titulo":"Subjetividad, memoria y su relación con el cuidado","resumen":"Seespone la experiencia de trabajo en los Talleres de la Tercera Edad que funcionan en la Universidad de Quilmes, para  la contribución de un envejecimiento exitoso.","palabras_clave":"TALLERES|ADULTOS MAYORES|CUIDADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87934,"idioma_id":5,"titulo":"El empleo de videos y animaciones en la clase de ciencias","resumen":"En el marco de una investigación más amplia sobre elempleo de TIC en la enseñanza de las ciencias llevamos adelante una línea detrabajo consistente en estudiar cómo algunos profesores de tercer año deBiología utilizan una serie de videos y animaciones en sus clases sobre el temasistema circulatorio humano (SCH). En el seguimiento de este proceso realizamosobservaciones de clase y entrevistas a los docentes. En este artículodescribimos un caso que consideramos representativo, compartimos lasreflexiones que surgen del análisis del mismo y una serie de propuestasalternativas.","palabras_clave":"VIDEOS Y SIMULACIONES|TIC|FORMACION PROFESORES|SISTEMA CIRCULATORIO HUMANO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87935,"idioma_id":5,"titulo":"Complejidad de lo interdisciplinar en las prácticas técnico profesionales en el campo de la educación. Una mirada epistemológica?.","resumen":"Desde inicios del siglo XX existen registros sobre la conformación en el sistema educativo argentino de servicios que tienen la función de atender aquellas problemáticas presentes en el escenario escolar. Las políticas públicas argentinas, especialmente a partir de la apertura democrática (1983), orientaron a que la intervención de estos servicios adquiriera un carácter interdisciplinar, a través de equipos técnicoprofesionales. El estado del arte muestra que la pregunta acerca del alcance de la intervención interdisciplinar de estos equipos técnicos sigue vigente. Interesados por esta cuestión y ante la observancia de experiencias diversas respecto de la posibilidad de circulación de saberes entre profesionales y equipos técnicos en la provincia de Río Negro, hemos desarrollado desde la Universidad Nacional del Comahue un trabajo de investigación, tomando como estudio de caso los equipos técnicos del nivel medio del sistema educativo. Es nuestra intención dar a conocer algunas reflexiones epistemológicas sobre aquellos datos obtenidos en esa investigación vinculados a los sentidos que adquiere la noción de interdisciplina en las normativas educativas y en las prácticas de los equipos técnicos.","palabras_clave":"interdisciplina|epistemología|intervención técnico profesional|educación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87936,"idioma_id":5,"titulo":"La cultura como campo de batalla. Fútbol y violencia en la Argentina","resumen":"La violencia relacionada con el deporte es un fenómeno de vieja data en América Latina, pero ha sido muy poco estudiado por fuera de la cobertura periodística; e incluso, esa cobertura debe ser objeto de análisis, en tanto recae en todos los lugares comunes de la estigmatización y el etnocentrismo. Por el contrario, utilizando información etnográfica así como análisis de coberturas periodísticas, este trabajo propone comprender los significados que tienen para los miembros de una hinchada de fútbol las prácticas violentas: y en ese camino, comprender esos significados como parte de una lucha por los sentidos culturales de la violencia y la pertenencia social.","palabras_clave":"VIOLENCIA|FUTBOL|HINCHADAS|AGUANTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87937,"idioma_id":5,"titulo":"Geodesia Empresaria - Contexto emocional","resumen":"Cuando el contexto emocional es el adecuado, se activan mecanismos que  dejan gravado el mensaje en el cerebro con huellas profundas, por cuanto la  emoción juega un papel importante en la memoria. Daniel Goleman ha demostrado  sólidamente que ésta es más importante que el cociente intelectual a la hora de  evaluar el éxito en las relaciones personales y el rendimiento en el trabajo","palabras_clave":"Pensamiento|Emociones|Conciencia|Relaciones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87938,"idioma_id":4,"titulo":"Grain sorption equilibria of algarroba flour","resumen":"chsvcdwqhvcwkivxnc asnv .s  1.\tGrain sorption equilibria of algarroba flour","palabras_clave":"isotermas|propiedades|algarrobo|fruto"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87939,"idioma_id":5,"titulo":"Determinación de la capacidad  antioxidante total y el contenido de polifenoles en diversas frutas.","resumen":"El consumo de alimentos con alto contenido en polifenoles y otros antioxidantes -como son las frutas y hortalizas- se traduce en una dieta particularmente benéfica para la salud. Se usó la técnica del radical ABTS+ para determinar la actividad antioxidante total en pulpas de frutas que existen en el mercado argentino. Se obtuvieron valores que están entre 19 y 629 mg\/100 gramos VCEAC (actividad antioxidante equivalente a vitamina C). Los polifenoles totales oscilaron entre 320 y 4820 ppm de ácido gálico.","palabras_clave":"ANTIOXIDANTES|FRUTAS|POLIFENOLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87940,"idioma_id":4,"titulo":"EFFECT OF RISPERIDONE AND FLUOXETINE ON THE MOVEMENT AND NEUROCHEMICAL CHANGES OF ZEBRAFISH","resumen":"Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down?s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperi-done and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was ob-served in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of&nbsp; these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.","palabras_clave":"Zebrafish|Risperidone|Serotonin|Fluoxetine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87941,"idioma_id":5,"titulo":"De la mesa de laboratorio al celuloide: el cine en la enseñanza de las ciencias","resumen":"En este artículo presentamos algunos elementos conceptuales para repensar la utilidad del cine, en particular del cine de ciencia ficción, en la enseñanza de las ciencias. Ofrecemos una estrategia didáctica, fuertemente anclada en el desarrollo conceptual \u2013cuya principal fortaleza es la capacidad de insertar la enseñanza de la ciencia en contextos sociales, materiales y políticos\u2013 y en su metodología. En tal sentido, para el desarrollo de la estrategia utilizamos el concepto de «prototipo diegético».","palabras_clave":"CINE|PROTOTIPOS DIEGÉTICOS|CIENCIA FICCIÓN |ESCENARIOS ESPECULATIVOS|PRODUCCIÓN DE CONOCIMIENTOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87942,"idioma_id":4,"titulo":"Ultrasound-assisted synthesis of unsymmetrical biaryls by Stille cross-coupling reactions","resumen":"We describe herein an efficient method for the synthesis of unsymmetrically-substituted biphenyls using a sonochemical variation of the Stille coupling, whose results have also been compared with the conventional silent reaction. Ultrasound significantly enhances this useful organometallic transformation affording products in higher yields and in shorter reaction times than non-irradiated reactions. The scope has been explored with a selection of arylstannanes as precursors and, remarkably, no by-products resulting from homo-coupling could be detected.","palabras_clave":"ULTRASOUND|STILLE CROSS-COUPLING|ARYLSTANNANES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87943,"idioma_id":4,"titulo":"Potassium phosphite primes defense responses in potato against Phytophthora infestans","resumen":"Although phosphite is widely used to protect plants from pathogenic oomycetes on a wide range of horticultural crops, the molecular mechanisms behind phosphite induced resistance are poorly understood.  The aim of this work was to assess the effects of potassium phosphite (KPhi) on potato plant defense responses to infection with Phytophtora infestans (Pi). Pathogen development was severely restricted and  there was also an important decrease in lesion size in infected KPhi-treated leaves. We demonstrated that KPhi primed hydrogen peroxide and superoxide anion production in potato leaves at 12 h postinoculation  with Pi. Moreover, the KPhi-treated leaves showed an increased and earlier callose deposition as compared with water-treated plants, beginning 48 h after inoculation. In contrast, callose deposition  was not detected in water-treated leaves until 72 h after inoculation. In addition, we carried out RNA gel  blot analysis of genes implicated in the responses mediated by salicylic (SA) and jasmonic acid (JA). To this end, we examined the temporal expression pattern of StNPR1 and StWRKY1, two transcription factors related to SA pathway, and StPR1 and StIPII, marker genes related to SA and JA pathways, respectively.  The expression of StNPR1 and StWRKY1 was enhanced in response to KPhi treatment. In contrast, StIPII was down regulated in both KPhi- and water-treated leaves, until 48 h after infection with Pi, suggesting  that the regulation of this gene could be independent of the KPhi treatment. Our results indicate that KPhi primes the plant for an earlier and more intense response to infection and that SA would mediate  this response","palabras_clave":"Defense responses|Phosphites|Phytophthora infestans | Potato"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87944,"idioma_id":4,"titulo":"Effect of glutens of different quality on dough characteristics and breadmaking performance","resumen":"Glutens of different quality were extracted from commercial flours of distinct breadmaking performance and employed as improvers at a level of 1 g\/100 g. The same flours used as a source of gluten were employed for testing the gluten effect. Flours were characterized by farinographic and alveographic assays and their protein profile was determined by SDS-PAGE. Rheology of each dough without and with gluten addition was studied by empirical and fundamental assays. Breadmaking performance was evaluated by loaf volume measurements and crumb texture. Though protein content was similar for all flours (11 g\/100 g), dough exhibited different breadmaking characteristics which could be related to a different gliadin\/glutenin proportion and a different protein profile. The weakest flour lacked two glutenin subunits (83 and 64.5 kDa) and showed a lower number of bands of gliadins respect to the other ones. Adding any of the three types of gluten to the weakest flour resulted in an increase of farinographic stability. The medium and inferior quality flours showed an increase in dough elasticity when the strongest gluten was added. In breadmaking assays the medium quality flour and its mixtures with gluten showed the highest specific volumes.","palabras_clave":"wheat flour|gluten quality|dough|breadmaking|rhelogy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87945,"idioma_id":4,"titulo":"Ultradeformable archaeosomes as new topical adjuvants","resumen":"Ultradeformable archaeosomes (UDA) are vesicles made of soybean phosphatidylcholine (SPC),sodium cholate (NaChol) and polar lipids from Halorubrum tebenquichense (3:1:3 wt\/wt). Whileultradeformable liposomes (UDL, made of SPC and NaChol at 6:1 wt\/wt) and UDA were neithercaptured nor caused cytotoxicity on keratinocytes, UDA was avidly captured by macrophages, beingtheir viability reduced by 0.4-1.6mg\/ml phospholipids, to 60-25 %. Instead, UDL were poorly capturedand caused no toxicity. Balb\/C mice immunized by the topical route with four doses of ovalbumin(OVA)-loaded UDA, at 75 &#61549;g OVA\/600 &#61549;g phospholipids (125 nm mean size and -42 mV Z potential),induced IgG titers ten to one hundred folds higher than those immunized with OVA loaded-UDL at thesame dosage. Both matrices penetrate to the same skin depth (nearly 10 &#61549;m after 1h on excisedhuman skin), being the higher topical adjuvancy and higher phagocytic uptake of UDA related to itsglycolipid content.","palabras_clave":"VESICLES|SKIN|TOPICAL ADJUVANTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87946,"idioma_id":4,"titulo":"Effect of the Addition of Proteins and Hydrocolloids on the Water Mobility in Gluten-Free Pasta Formulations","resumen":"In a gluten free pasta formulation (suitable for celiac people), the influence of each constituent has a major importance on the final product quality, especially water and hydrocolloids contents used to replace the gluten matrix. The presence of hydrocolloids and proteins in dough may modify the availability of water to interact with starch in the gelatinization process.   The aim of the present work was to investigate the effect of proteins and hydrocolloids addition on the water-starch interaction using a triangular mixture design. Basic dough formula consisted in a mixture of corn starch and flour (4:1, 53.5%), 1%NaCl, and 3% sunflower oil, water (35.48-39.5%), gums (xanthan and locust bean gums, 2:1 ratio, 0.512-2.519%), and proteins (dry egg and ovoalbumin mixtures, 10:1 ratio, 0.683-6.704%) Combinations of gums, proteins, and water were used in a simplex-centroid design with constrains.  Modulated differential scanning calorimetry was used to study starch gelatinization and the amount of unfrozen water in the samples; thermograms were obtained between -50ºC and 140ºC (heating rate 5ºC\/min, modulated at &#61617;1ºC, period of 60s). Regarding the process of gelatinization, a biphasic endotherm was observed; when the free water content of the dough was progressively reduced (94 to 42g H2O\/ 100g dough), endotherms shifted to higher temperatures (onset from 56.7ºC to 63.1ºC, first peak from 75.1 to 77.6ºC) following a linear relationship. The response surface analysis of the unfrozen water content of the complex composite system as a function of the concentration of proteins, hydrocolloids, and water led to a ?saddle? type surface, involving interactions between components.","palabras_clave":"DIFFERENTIAL SCANNING CALORIMETRY|MIXTURE DESIGN|HYDROCOLLOIDS|GLUTEN-FREE PASTA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87947,"idioma_id":4,"titulo":"Morphology of the Eye of the Southern Right Whales  (Eubalaena australis)","resumen":"Recently, there has been a growing interest in the anatomy and optics of the visual system of cetaceans. However, much of the new information has been focused on odontocetes, and relatively little is known about the visual anatomy of baleen whales. The aim of this study was describe the eye anatomy of the southern right whale (Eubalaena australis). Eye samples were collected from 26 calves, four adults with known body length, as well as two specimens of unknown body length that had stranded near their nursery ground at Península Valdés, Argentina, over 6 years. We provide anatomical descriptions of the eyeball and extraocular structures, as well as quantitative data in the form of eyeball, corneal, scleral, and lens measurements. To explore the sensitivity of the eye to light, the f-number was estimated in one specimen. We found that the eyes of the calves differed from those of the adults in having less periorbital fat surrounding the eyeball. We also observed variations in the abundance of periorbital fat among the adult specimens. The regression analysis revealed a correlation between body length and eyeball size. By contrast, the dimensions of the cornea were only weakly correlated with body length. The estimated f-number suggests that the optical sensitivity of the Eubalaena australis eye is relatively low. However, caution had to be taken in interpreting f-number as a proxy of eye sensitivity because it depends on the lens size, which can be affected by the fixation methods used.","palabras_clave":"EUBALAENA AUSTRALIS|EYE MORPHOLOGY|PERIORBITAL FAT|OPTICAL SENSITIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87948,"idioma_id":4,"titulo":"?\tBiosorption of Cu(II), Zn(II), Cd(II) and Pb(II) by dead biomasses of green alga Ulva Lactuca and the development of a sustainable matrix for adsorption implementation","resumen":"Many industries have high heavy metals concentrations in their effluents that should be treated before disposal in drains or natural watercourses. When adsorption process is evaluated to generate and implement an efficient, economical and sustainable method suitable for heavy metals removal from contaminated effluents, it is necessary to develop an experimental setup that contains the adsorbent. Ulva lactuca, a marine green alga, was studied as a natural biosorbent for heavy metals at acid pH conditions. Adsorption experiments were carried out in glass columns and in batch where the alga was suspended or fixed in an agar matrix. Langmuir and Freundlich models were applied to the experimental results. Langmuir model best describes the adsorption isotherms in all analyzed cases. The adsorption capacity increases with pH. Kinetic studies demonstrate that, in most studied cases, the adsorption follows a pseudo second order kinetics model.Removal efficiencies of the biomaterial supported in agar or fixed in columns were: fixed in columns> suspended in batch mode> fixed in agar. Finally, the effect of the presence of two sorbates, Cd and Pb, in the solution was measured and results demonstrate that adsorption of both metals are diminished by co\/adsorption.","palabras_clave":"Biosorption|Adsorption matrix|Metal removal|Ulva lactuca"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87949,"idioma_id":4,"titulo":"Population Structure of the SW Atlantic Estuarine Crab Neohelice granulata Throughout Its Range: a Genetic and Morphometric Study","resumen":"Phylogeographic patterns of the SW Atlantic estuarine crab Neohelice granulata were examined using mitochondrial DNA cytochrome oxidase I sequences and analyzed together with morphometric data. Specimens were sampled during a 4-year period (2001?2004) from 11 localities encompassing the full distributional range of this species along the SW Atlantic (22°57&#8242; S to 42°25&#8242; S). DNA sequences were obtained from 69 individuals belonging to seven localities, and morphometric variation in 12 continuous characters was analyzed for 646 crabs from ten localities. Strong genetic differentiation, consistent with a pattern of isolation-by-distance, was detected among all localities indicating that gene flow occurs mainly between neighboring populations. Analyses of molecular variance showed genetic subdivision between the southern (Argentina) and the northern (Brazil) sites, suggesting restricted gene flow at a regional scale. The genetic structure of this species could be divided into two distinct groups due to a limited gene flow between southern and northern regions as a consequence of larval dispersal patterns. Coastal currents in the vicinity of the Rio de la Plata likely act as a barrier to dispersal within the species range. Moreover, genetic data indicate that populations of N. granulata might have undergone a northward demographic expansion since the late Pleistocene. The morphometric analysis showed no geographical pattern of morphological differentiation, although there were differences among sampling sites.","palabras_clave":"LARVAL DISPERSAL|CRAB POPULATIONS|MTDNA SEQUENCES|PHYLOGEOGRAPHY|MORPHOMETRICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87950,"idioma_id":4,"titulo":"Chromosomal Axis Formation and Meiotic Progression in Chicken Oocytes: A Quantitative Analysis","resumen":"The assembly and disassembly of the synaptonemal complexes (SCs) correlate with the progression of meiotic prophase I. Using immunostaining of the cohesin component SMC3, which is present in the axial elements of the SC, we characterized the synaptic process in chicken oocytes and quantified the frequency of the different prophase stages at hatching and at 3 different ages after hatching. The analysis provides detailed quantitative data regarding the meiotic stages in the chicken ovary showing that the maximum amount of pachytene oocytes is found around hatching and that oocytes reach the diplotene stage 5 days after entering into meiosis. We confirmed the asynchrony of the meiotic development in the female chicken gonad showing that the ovary has a composite population of cells at different stages from day 17 before hatching and for several days after hatching. The significance of these results is discussed in relationship to functional experimental procedures that involve avian oocytes.","palabras_clave":"CHICKEN|MEIOSIS|OOGENESIS|SYNAPTONEMAL COMPLEX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87951,"idioma_id":4,"titulo":"Prolactin Receptor  antagonism in mouse anterior pituitary: effects on cell turnover and prolactin receptor expression","resumen":"Cell turnover in the anterior pituitary (AP) of female rats is coordinated by circulating levels of gonadal steroids. During proestrus the rate of AP apoptosis is the highest and a peak in circulating levels of prolactin (PRL) occurs. Since we have previously demonstrated that PRL exerts autocrine\/paracrine actions on AP cells inducing apoptosis and decreasing proliferation, the aim of this study was to investigate the in vivo effect of PRL on female AP cell proliferation and apoptosis  rates. The administration of PRL and sulpiride-induced hyperprolactinemia  decreased proliferation and increased apoptosis in the AP gland of ovariectomized rats. Apoptosis in the AP gland of female mice was higher at proestrus than at diestrus. These variations were not observed in PRLR KO mice, suggesting that PRL is involved in the peak of AP cell apoptosis that occurs at proestrus. We  evaluated if PRL receptor (PRLR) expression varies along the estrous cycle and if  PRL regulates its own receptor expression in the AP gland, using female transgenic mice that systemically express PRLR antagonist 1-9-G129R-hPRL. PRLR expression, measured by real time PCR, was variable during the estrous cycle and PRLR antagonism modified the expression of PRLR in an isoform-specific manner. These results suggest that endogenous PRL regulates its AP actions by modifying the expression of PRLR isoforms. Our observations suggest that PRL is involved in the maintenance of cell renewal in the AP that occurs during each estrous cycle in females. Alterations in this physiological role of PRL could contribute to pituitary tumor development.","palabras_clave":"APOPTOSIS|PROLIFERATION|Delta 1-9-G129-hPRL|PROLACTIN|PITUITARY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87952,"idioma_id":4,"titulo":"Precipitation patterns dissolved organic matter and changes in the plankton assemblage in Lake Escondido (Patagonia, Argentina).","resumen":"            Global warming affects the hydrological cycle by increasing the  frequency and intensity of extreme rainfall events and dry spells. These events  affect the dissolved organic matter (DOM) input into lakes. In the current study,  we investigated if changes in precipitation over a three-year period correspond  to changes in DOM that in turn affect light attenuation and plankton community  composition.&nbsp; We carried out field studies  in a shallow, oligotrophic Andean lake, analyzing coloured DOM and plankton  community composition. During the study period, we observed that variations in  the precipitation regime correlated with DOM parameters (water colour and  molecular weight), and this, in turn, affected the plankton composition. We  observed differences in the Bacteria:Archaea ratio suggesting that Archaea  were favoured under high DOM molecular weight, water colour, and TDP.&nbsp; Chlorophyll a concentrations of both  phytoplanktonic fractions (&lt; and &gt; 2 µm) were also related to water  colour and TDP.&nbsp; We observed in the small  fraction (&lt; 2 µm) an increase in phycocyanin-rich cells during periods of  low transparency. Larger phytoplanktonic cells (&gt; 2 µm) presented two  biomass peaks corresponding to increases of the cyanophyte Chroococcus  planctonicus and of the haptophyte Chrysochromulina parva. As  precipitation decreased, the lake became more transparent, favouring C.  planctonicum and mixotrophic oligotrich ciliates with endosymbiotic Chlorella.  In the context of global climate change, our results highlight the impact of  changes in precipitation patterns and, consequently, in DOM quality on the  plankton community of shallow oligotrophic lakes. ","palabras_clave":"Precipitation|Dissolved organic matter|Plankton community|Shallow oligotrophic Andean lake"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87953,"idioma_id":4,"titulo":"Are Smartphones Really Useful for Scientific Computing?","resumen":"Smartphones are a new kind of mobile devices that allow users to take their office anywhere and anytime with them. The number of smartphones is rapidly growing. Most of the time their capabilities are underused, therefore several authors have studied how to exploit smartphones for assisting scientific computing. Yet, as far as we know, there is no study aimed at determining whether smartphones can do a significant contribution to this area as resource providers. This paper shows that smartphones are not that slow when compared to standard mobile devices, such as notebooks. Furthermore, a notebook running on battery only performed 8 times more work than a low-end smartphone before their batteries run out. However, the low-end smartphone is 145 times slower than the notebook, and the smartphone battery has less capacity than the notebook battery. Since smartphones can execute large amount of work running on battery, we think that smartphones can have a major role in building the next-generation HPC infrastructures.","palabras_clave":"SMARTPHONES|ANDROID|SCIENTIFIC COMPUTING|BENCHMARK|LINPACK|SCIMARK"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87954,"idioma_id":4,"titulo":"Agglutinating activity and structural characterization of scalarin, the major egg protein of the snail Pomacea scalaris (d'Orbigny, 1832)","resumen":"Apple snail perivitellins are emerging as ecologically important reproductive proteins. To elucidate if the protective functions of the egg proteins of Pomacea canaliculata (Caenogastropoda, Ampullariidae), involved in embryo defenses, are present in other Pomacea species we studied scalarin (PsSC), the major perivitellin of Pomacea scalaris. Using small angle X-ray scattering, fluorescence and absorption spectroscopy and biochemical methods, we analyzed PsSC structural stability, agglutinating activity, sugar specificity and protease resistance. PsSC aggluttinated rabbit, and, to a lesser extent, human B and A erythrocytes independently of divalent metals Ca2+ and Mg2+; being strongly inhibited by galactosamine and glucosamine. The protein was structurally stable between pH 2.0 to 10.0, though agglutination occurred only between pH 4.0 to 8.0 (maximum activity at pH 7.0). The agglutinating activity was conserved up to 60°C and completely lost above 80°C, in agreement with the structural thermal stability of the protein (up to 60 °C). PsSC was able to withstand in vitro gastrointestinal digestion, and showed no trypsin inhibition activity.   The presence of lectin activity has been reported in eggs of other Pomacea snails, but here we link for the first time, this activity to an apple snail multifunctional perivitellin. This novel role for a snail egg storage protein is different from close related P.canaliculata defensive protein.","palabras_clave":"APPLE SNAIL|PERIVITELLIN|CAROTENOPROTEIN|PsSC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87955,"idioma_id":4,"titulo":"Constraints on the origin of cosmic rays above 1018 eV from large scale anisotropy searches in data of the Pierre Auger Observatory","resumen":"A thorough search for large scale anisotropies in the distribution of arrivaldirections of cosmic rays detected above $10^{18}$ eV at the Pierre AugerObservatory is reported. For the first time, these large scale anisotropysearches are performed as a function of both the right ascension and thedeclination and expressed in terms of dipole and quadrupole moments. Within thesystematic uncertainties, no significant deviation from isotropy is revealed.Upper limits on dipole and quadrupole amplitudes are derived under thehypothesis that any cosmic ray anisotropy is dominated by such moments in thisenergy range. These upper limits provide constraints on the production ofcosmic rays above $10^{18}$ eV, since they allow us to challenge an origin fromstationary galactic sources densely distributed in the galactic disk andemitting predominantly light particles in all directions.","palabras_clave":"astroparticle physics| cosmic rays"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87956,"idioma_id":4,"titulo":"Results of a self-triggered prototype system for radio-detection of extensive air showers at the Pierre Auger Observatory","resumen":"We describe the experimental setup and the results of RAuger, a small radio-antennaarray, consisting of three fully autonomous and self-triggered radio-detection stations, installed close to the center of the Surface Detector (SD) of the Pierre Auger Observatory in Argentina. The setup has been designed for the detection of the electric field strength of air showers initiated by ultra-high energy cosmic rays, without using an auxiliary trigger from another detection system.Installed in December 2006, RAuger was terminated in May 2010 after 65 registered&nbsp; coincidences with the SD. The sky map in local angular coordinates (i.e., zenith and azimuth angles) of these events reveals a strong azimuthal asymmetry which is in agreement with a mechanism dominated by a geomagnetic emission process. The correlation between the electric field and the energy of the primary cosmic ray is presented for the first time, in an energy range covering two orders of magnitude between 0.1 EeV and 10 EeV. It is demonstrated that this setup is relatively more sensitive to inclined showers, with respect to the SD. In addition to these results, which underline the potential of the radio-detection technique, important information about the general behavior of self-triggering radio-detection systems has been obtained. In particular, we will discuss radio self-triggering under varying local electric-field conditions.","palabras_clave":"Antennas|Large detector systems for particle and astroparticle physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87957,"idioma_id":4,"titulo":"Asymmetric forest transition driven by the interaction of socioeconomic development and environmental heterogeneity in Central America","resumen":"Forest transitions (FT) have been observed in many developed  countries and more recently in the developing world. However,  our knowledge of FT from tropical regions is mostly derived from  case studies from within a particular country, making it difficult to  generalize findings across larger regions. Here we overcome these  difficulties by conducting a recent (2001\u20132010) satellite-based analysis  of trends in forest cover across Central America, stratified by biomes,  which we related to socioeconomic variables associated with  human development. Results show a net decrease of woody vegetation  resulting from 12,201 km2 of deforestation of moist forests  and 6,825 km2 of regrowth of conifer and dry forests. The Human  Development Index was the socioeconomic variable best associated  with forest cover change. The least-developed countries, Nicaragua  and Guatemala, experienced both rapid deforestation of moist forests  and significant recovery of conifer and dry forests. In contrast,  the most developed countries, Panama and Costa Rica, had net  woody vegetation gain and amore stable forest cover configuration.  These results imply a good agreement with FT predictions of forest  change in relation to socioeconomic development, but strong asymmetry  in rates and directions of change largely dependent upon the  biomewhere change is occurring. The FT model should be refined by  incorporating ecological and socioeconomic heterogeneity, particularly  inmulticountry and regional studies. These asymmetric patterns  of forest change should be evaluatedwhen developing strategies for  conserving biodiversity and environmental services.","palabras_clave":"Forest Transition|Development|Land Use Change|Central America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87958,"idioma_id":4,"titulo":"A Search for Point Sources of EeV Neutrons","resumen":"A thorough search of the sky exposed at the Pierre Auger Cosmic Ray Observatory reveals no statistically significant excess of events in any small solid angle that would be indicative of a flux of neutral particles from a discrete source.The search covers from -0° to +15° in declination using four different energy ranges above 1 EeV (1018 eV). The method used in this search is more sensitive to neutrons than to photons. The upper limit on a neutron flux is derived for a dense grid of directions for each of the four energy ranges. These results constrain scenarios for the production of ultrahigh energy cosmic rays in the Galaxy. &nbsp;","palabras_clave":"UHECR Cosmic Rays|Pierre Auger Observatory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87959,"idioma_id":4,"titulo":"Large scale distribution of arrival directions of cosmic rays detected above $10^{18}$ eV at the Pierre Auger Observatory","resumen":"A thorough search for large-scale anisotropies in the distribution of arrival directions of cosmic rays detected above 1018 eV at the Pierre Auger Observatory is presented. This search is performed as a function of both declinationand right ascension in several energy ranges above 1018 eV, and reported in terms of dipolar and quadrupolar coefficients. Within the systematic uncertainties, no significant deviation from isotropy is revealed. Assuming that any cosmic-ray anisotropy is dominated by dipole and quadrupole moments in this energy range, upper limits on their amplitudes are derived. These upper limits allow us to test the origin of cosmic rays above 1018 eV fromstationary Galactic sources densely distributed in the Galactic disk and predominantly emitting light particles in alldirections.&nbsp;","palabras_clave":"Ultra-High Energy Cosmic Rays|Pierre Auger Observatory|Large Scale Anisotropies"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87960,"idioma_id":4,"titulo":"Antennas for the Detection of Radio Emission Pulses from Cosmic-Ray","resumen":"Antennas...","palabras_clave":"UHECRs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87961,"idioma_id":4,"titulo":"Search for point-like sources of ultra-high energy neutrinos at the  Pierre Auger Observatory and improved limit on the diffuse flux of tau neutrinos","resumen":"The Surface Detector array of the Pierre Auger Observatory can detect  neutrinos with energy between 10^17 eV and 10^20 eV from point-like sources  across the sky south of +55 deg and north of -65 deg declinations. A search has  been performed for highly inclined extensive air showers produced by the  interaction of neutrinos of all flavours in the atmosphere (downward-going  neutrinos), and by the decay of tau leptons originating from tau neutrinos  interactions in the Earth´s crust (Earth-skimming neutrinos). No candidate  neutrinos have been found in data up to 2010 May 31. This corresponds to an  equivalent exposure of ~3.5 years of a full surface detector array for the  Earth-skimming channel and ~2 years for the downward-going channel. An improved  upper limit on the diffuse flux of tau neutrinos has been derived. Upper limits  on the neutrino flux from point-like sources have been derived as a function of  the source declination. Assuming a differential neutrino flux k_PS E^-2 from a  point-like source, 90% C.L. upper limits for k_PS at the level of ~5 x 10^-7  and 2.5 x 10^-6 GeV cm^-2 s^-1 have been obtained over a broad range of  declinations from the searches of Earth-skimming and downward-going neutrinos,  respectively.","palabras_clave":"astroparticle physics|cosmic rays|neutrinos|telescopes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87962,"idioma_id":4,"titulo":"The Rapid Atmospheric Monitoring System of the Pierre Auger  Observatory.","resumen":"The Pierre Auger Observatory is a facility built to detect air showers produced by cosmic rays above 1017 eV. During clear nights with a low illuminated moon fraction, the UV fluorescence light produced by air showers is recorded by optical telescopes at the Observatory. To correct the observations for variations in atmospheric conditions, atmospheric monitoring is performed at regular intervals ranging from several minutes (for cloud identification) to several hours (for aerosol conditions) to several days (for vertical profiles of temperature, pressure, and humidity). In 2009, the monitoring program was upgraded to allow for additional targeted measurements of atmospheric conditions shortly after the detection of air showers of special interest, e. g., showers produced by very high-energy cosmic rays or showers with atypical longitudinal profiles. The former events are of particular importance for the determination of the energy scale of the Observatory, and the latter are characteristic of unusual air shower physics or exotic primary particle types. The purpose of targeted (or 'rapid') monitoring is to improve the resolution of the atmospheric measurements for such events. In this paper, we report on the implementation of the rapid monitoring program and its current status. The rapid monitoring data have been analyzed and applied to the reconstruction of air showers of high interest, and indicate that the air fluorescence measurements affected by clouds and aerosols are effectively corrected using measurements from the regular atmospheric monitoring program. We find that the rapid monitoring program has potential for supporting dedicated physics analyses beyond the standard event reconstruction","palabras_clave":"Real-time monitoring|Control and monitor systems online"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87963,"idioma_id":4,"titulo":"Measurement of the cosmic ray energy spectrum using hybrid events of the Pierre Auger Observatory","resumen":"The European Physical Journal Plus 127, 87 (2012)  \/\/\/  The energy spectrum of ultra-high energy cosmic rays above 1018 eV is measured using the hybrid events collected by the Pierre Auger Observatory between November 2005 and September 2010. The large exposure of the Observatory allows the measurement of the main features of the energy spectrum with high statistics. Full Monte Carlo simulations of the extensive air showers (based  on the CORSIKA code) and of the hybrid detector response are adopted here as an independent cross check of the standard analysis (Phys. Lett. B 685, 239 (2010)). The dependence on mass composition and other systematic uncertainties are discussed in detail and, in the full Monte Carlo approach, a region of confidence for flux measurements is defined when all the uncertainties are taken into account. An update is also reported of the energy spectrum obtained by combining the hybrid spectrum and that measured using the surface detector array.","palabras_clave":"Cosmic rays|Energy spectrum|Pierre Auger Observatory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87964,"idioma_id":4,"titulo":"A search for anisotropy in the arrival directions of ultra high energy  cosmic rays recorded at the Pierre Auger Observatory","resumen":"Observations of cosmic ray arrival directions made with the Pierre Auger Observatory have previously provided evidence of anisotropy at the 99% CL using the correlation of ultra high energy cosmic rays (UHECRs) with objects drawn from the Véron-Cetty Véron catalog. In this paper we report on the use of three catalog independent methods to search for anisotropy. The 2pt?L, 2pt+ and 3pt methods, each giving a different measure of self-clustering in arrival directions, were tested on mock cosmic ray data sets to study the impacts of sample size and magnetic smearing on their results, accounting for both angular and energy resolutions. If the sources of UHECRs follow the same large scale structure as ordinary galaxies in the local Universe and if UHECRs are deflected no more than a few degrees, a study of mock maps suggests that these three methods can efficiently respond to the resulting anisotropy with a P-value = 1.0% or smaller with data sets as few as 100 events. Using data taken from January 1, 2004 to July 31, 2010 we examined the 20,30,...,110 highest energy events with a corresponding minimum energy threshold of about 49.3 EeV. The minimum P-values found were 13.5% using the 2pt-L method, 1.0% using the 2pt+ method and 1.1% using the 3pt method for the highest 100 energy events. In view of the multiple (correlated) scans performed on the data set, these catalog-independent methods do not yield strong evidence of anisotropy in the highest energy cosmic rays.","palabras_clave":"UHECR Cosmic Rays |Pierre Auger Observatory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87965,"idioma_id":5,"titulo":"Determinación del punto de impacto del eje de EAS inclinadas y su efecto en la  composición primaria.","resumen":"El Observatorio Pierre Auger ha sido dise~nado como un detector hbrido combinando detectoresde partculas Cherenkov cubriendo una supercie de 3000 km2 y 24 telescopios de&nbsp;uorescencia en laperiferia del arreglo de supercie. En este trabajo presentamos el efecto de la determinacion del puntode impacto de lluvias inclinadas en el analisis de un observable que permite estudiar la composicionprimaria de los rayos cosmicos de ultra alta energa por encima de los 3;16  1018 eV.","palabras_clave":"rayos Cosmiocs|composición primaria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87966,"idioma_id":4,"titulo":"Meandering tidal-fluvial channels and lag concentration of terrestrial vertebrates in the fluvial-tidal transition of an ancient estuary in Patagonia","resumen":"The La Pastosa beds constitute a nice example of sediments deposited in the  highly meandering reach of the fluvial-tidal transition within an estuary, developed  at the top of the ?Rionegrense? stage, a marine-estuarine sequence of late Miocene  age from Patagonia. Sedimentary facies include channel lags rich in mud intraclasts;  cross-bedded sandstones with mud drapes and ?set-climber? ripples; heterolithic  and herringbone bedding; and inclined heterolithic stratification (IHS), and suggest  a strong tidal influence. Tidal facies together with paucity of bioturbation and  marine fossils indicate that sedimentation took place mainly in brackish tidal-fluvial channels, bounded by deposits formed in transgressive conditions at the base and at the top of the succession. Channel lag intraformational conglomerates are product of collapse of the cutbank due to erosion in the active margin of lateral migrating meandering channels that eroded adjacent muddy tidal flats and salt marshes. Crossbedded sandstones were accumulated above the conglomerates, forming subtidal sand dunes in the deeper parts of the channels and IHS was formed in point bars.  Discontinuities at the base of the channels are the result of the entire channel-system lateral migration, whereas discontinuities capped by small mud pebbles at the base of large IHS sets are the result of seasonally increased run-off and widening of the channels. Alternation of sandy and muddy IHS suggests periodical changes in the position of the turbidity maximum due to seasonal variation of fluvial discharge, in good agreement with the seasonal climate in Patagonia during the late Miocene. IHS sets dipping alternatively to the north and south indicate lateral migration of the east-west running, high-sinuosity channels in the tightly meandering reach of the tidal-fluvial transition. The well preserved vertebrate fauna of Huayquerian mammal age is dominated by the hydrocherid Cardiatherium patagonicum together with whistling ducks and loricariid fishes. This fauna inhabited out-of-channel, freshwater, low-energy restricted environments, like marshes and ponds where the carcasses accumulated and underwent diagenetic fossilization. Repeated lateral migration of meandering channels caused erosion of these deposits and the bones were exhumed and incorporated into the channels, and finally concentrated in channel lags after short transport. Combination of fossilization in a low-energy environment and concentration after short transport in meandering channels make the fluvial-tidal transition ?first class? deposits for prospecting vertebrate fossils.  In spite of exhumation and transport, vertebrate fossil association closely reflects the environments adjacent to the channels. Excellent preservation is more related to  rapid burial than to the energy level of the environment of final accumulation.","palabras_clave":"Fluvial-tidal transition|Miocene|Sedimentology|Taphonomy|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87967,"idioma_id":4,"titulo":"Identification of a unique gene cluster of Brucella spp. that mediates adhesion to host cells","resumen":"Brucella, the causative agent of brucellosis, a major zoonotic disease affecting a broad range of mammals, is a gram-negative bacterium whose virulence is dependent on the capacity to attach and invade different cells of the host. The bacterium is able to infect through a diverse repertoire of epitheliums: skin, airways or gastric. Although much has been studied on the mechanisms Brucella uses to establish an intracellular replication niche, almost none is known on how the bacterium adheres and invades host cells. We report here the identification of a pathogenicity island that harbors a gene homologous to proteins with bacterial immunoglobulin-like domains present in other pathogens that play a role in attachment and invasion. Deletion of the entire island results in a mutant with a reduced attachment capacity measured by intracellular replication and adhesion assays. Intraperitoneal and oral experimental infection of mice strongly suggests that this island plays a role during the oral infection probably mediating attachment and trespassing of the gastric epithelium to establish a systemic infection.","palabras_clave":"BRUCELLA ABORTUS|ADHESION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87968,"idioma_id":4,"titulo":"Aromatic Radical Perfluoroalkylation Reactions","resumen":"Canadian Journal of Chemistry, Published on the web 9 May 2012, 10.1139\/v2012-026   http:\/\/dx.doi.org\/10.1139\/v2012-026  This account intends to cover recent literature on radical perfluoroalkylation reactions of aromatic nuclei in organic and aqueous media. The radical reactions will not include those mediated by metals, as these have been the subject of recent review articles. Emphasis will be made on radical aromatic perfluoroalkylation reactions in water and or aqueous media, with the aim at exploring aromatic radical reactivity in a benign environment","palabras_clave":"radical perfluoroalkylation|radicals in aqueous media|aromatic radical perfluoroalkylation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87969,"idioma_id":4,"titulo":"Gas flow in a channel semiobstructed by a porous media","resumen":"An experimental study of a gas &#64258;ow in a narrow channel partially obstructed by a regular array of wires is presented. The velocity pro&#64257;le along the channel was measured by means of a hot-wire anemometer, inside and outside the obstructed region. Flow instabilities were found in the free zone adjacent to the porous region, which were&nbsp; characterized by the standard deviation and the power spectrum of the signal of the anemometer. The experimental pro&#64257;les were comparedwith numerical simulations using a two-dimensional Lattice Boltzmann model.","palabras_clave":"Porous media|Gas flow|Instabilities|Lattice Boltzmann"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87970,"idioma_id":4,"titulo":"Variable structural controls through time in the Southern Central Andes (~36ºS)","resumen":"The Southern Central Andes at 36ºS have been recognized as an orogenic belt where contraction, accommodated  mainly by basement structures, is associated with the inversion of a Late Triassic-Early Jurassic extensional  detachment. Based on a structural cross-section, constrained by field data, 2D seismic and bore-hole information, and  the processing of Bouger anomalies, we propose a polyphasic tectonic evolution. In the westernmost sector, along the  axis of the Cordillera, NW to NNW basement structures were inverted, being a first order control in the generation of  frontal narrow N-trending thin-skinned belts. This slip transfer is controlled by the Late Jurassic main detachment. These  structures have low gravity anomalies that cross obliquely the main Andean trend. East of this inversion domain, beneath  the frontal thin-skinned belts, seismic information reveals that Late Triassic wedge-like depocenters did not experience  substantial inversion. To the east double-vergent basement blocks define the Andean emergent orogenic front at these  latitudes. These contractional structures truncate gravity anomalies defined by basement discontinuities, indicating that  they are not related to tectonic inversion, in contraposition to the westernmost domain. Two contractional phases were  distinguished. The oldest is Late Cretaceous in age, as inferred from onlap relations in Upper Cretaceous strata identified  in seismic lines. These successions have a maximum age of 97 Ma as inferred by U-Pb in detrital zircons published  in previous studies in the area. Contrastingly, the easternmost sector was mainly deformed in Late Miocene times as  inferred from less than 18 Ma old synorogenic deposits. Moreover, contractional mechanisms varied through time for  each specific sector. While Late Cretaceous contractional tectonics was generated by tectonic inversion and subordinate  thin-skinned deformation, it is proposed that Late Miocene deformation was controlled mainly by brittle-ductile transitions  at the upper crust with no major influence of previous structures. This fact can be explained by a higher thermal  flux achieved in the retroarc area in the last 17 Ma due to the eastward arc expansion during a shallow subduction regime.","palabras_clave":"Central Andes|Malargüe fold and thrust belt|Tectonic inversion|Brittle-ductile transitions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87971,"idioma_id":4,"titulo":"GOCE satellite derived gravity and gravity gradient corrected for topographic effect in the South Central Andes region","resumen":"  Global gravity field models, derived from satellite measurements integrated with terrestrial  observations, provide a model of the Earth?s gravity field with high spatial resolution and accuracy.  The Earth Gravity Model EGM08, a spherical harmonic expansion of the geopotential  up to degree and order 2159, has been used to calculate two functionals of the geopotential:  the gravity anomaly and the vertical gravity gradient applied to the South Central Andes area.  The satellite-only field of the highest resolution has been developed with the observations of  satellite GOCE, up to degree and order 250. The topographic effect, a fundamental quantity for  the downward continuation and validation of satellite gravity gradiometry data, was calculated  from a digital elevation model which was converted into a set of tesseroids. This data is used to  calculate the anomalous potential and vertical gravity gradient. In the Southern Central Andes  region the geological structures are very complex, but not well resolved. The processing and  interpreting of the gravity anomaly and vertical gradients allow the comparison with geological  maps and known tectonic structures. Using this as a basis, a few features can be clearly  depicted as the contact between Pacific oceanic crust and the Andean fold and thrust belt,  the seamount chains over the Oceanic Nazca Plate, and the Famatinian and Pampean Ranges.  Moreover the contact between the Rio de la Plata craton and the Pampia Terrain is of great  interest, since it represents a boundary that has not been clearly defined until now. Another  great lineament, the Valle Fertil-Desaguadero mega-lineament, an expression of the contact  between Cuyania and Pampia terranes, can also be clearly depicted. The authors attempt to  demonstrate that the new gravity fields can be used for identifying geological features, and  therefore serve as useful innovative tools in geophysical exploration.","palabras_clave":"Satellite gravity|Gravity anomalies and Earth structure|Ultra-high pressure metamorphism|Cratons|Continental margins: convergent|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87972,"idioma_id":4,"titulo":"Arbuscular mycorrhizal fungal species in saline environments of Central Argentina: seasonal variation and distribution of spores at different soil depths","resumen":"Natural saline soils of Central Argentina have rarely been the focus of arbuscularmycorrhizal fungi (AMF) which are Glomeromycota. We explored the vertical distributionof spores of different AMF species in the rhizosphere of Atriplex lampa in two saline environments(Salinas Grandes and Salinas de Ambargasta) during wet and dry seasons.18 AMF species were identified. Spore numbers were highest at Salinas Grandes during thewet season. Soil depth showed an influence on spore abundance of some specific species.Our results highlight the effect of soil depth, seasons and soil characteristics on sporulationof AMF species under saline conditions.","palabras_clave":"SALINE SOILS|SOIL PROFILE|ATRIPLEX LAMPA|GLOMEROMYCOTA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87973,"idioma_id":4,"titulo":"Research on plants for the understanding of diseases of nuclear and mitochondrial origin","resumen":"Different model organisms, such as Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse, cultured human cell lines, among others, were used to study the mechanisms of several human diseases. Since human genes and proteins have been structurally and functionally conserved in plant organisms, the use of plants, especially Arabidopsis thaliana, as a model system to relate molecular defects to clinical disorders has recently increased. Here, we briefly review our current knowledge of human diseases of nuclear and mitochondrial origin and summarize the experimental findings of plant homologs implicated in each process","palabras_clave":"DNA Repair Genetic Disorders|Mitochondrial Disorders"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87974,"idioma_id":4,"titulo":"Contribution of yeast and plant research for improving human health","resumen":"In the last years there was an increase in the use of several organisms such as plants and yeast for medical and biotechnological purposes. Both organisms are very useful when research in humans is nonpossible or unfeasible due to ethical issues. There are several advantages of using model organisms such as the availability of genomic information, the possibility to easily make genetic manipulation and screenings, and availability of mutants in desired genes. In addition, these organisms are generally easy to grow.","palabras_clave":"Saccharomyces cerevisiae|Arabidopsis thaliana|biotechnological and biomedical purposes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87975,"idioma_id":4,"titulo":"CORROSION RESISTANCE OF STEEL\/ZINC WITH SILICATE NANOPARTICLES\/ POLYURETHANE PAINT SYSTEMS IN NaCl SOLUTION","resumen":"Surface characteristics and corrosion behaviour of bare electrogalvanized steel coated with polymer\/nano-silicate particles added to the electrogalvanizing bath were studied by scanning electron microscopy (SEM), energy dispersive spectrometer (EDXS) and electrochemical impedance spectroscopy (EIS). After applying a barrier polyurethane paint, the paint hardness, porosity, flexibility, colour, gloss, blistering and rusting degrees, and anticorrosive protective properties in 0.05 mol·L-1 NaCl solution were also evaluated. The results correlated well and, being demonstrative of the very slow deterioration rate of the immersed coated electrogalvanized steel, they enabled to assume that if a chemically analogous but thicker coating system was applied; it could be an acceptable alternative in real service conditions.","palabras_clave":"ELECTROGALVANIZED STEEL|CONVERSION TREATMENT|EIS|CORROSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87976,"idioma_id":4,"titulo":"BEHAVIOR OF ELECTROGALVANIZED STEEL PRE-TREATED WITH Cr (III)-BASED BATHS AND EXPOSED TO 0.5M Na2SO4 SOLUTION","resumen":"As Cr (VI) compounds used to formulate conversion layers provide enhanced anticorrosive protection to zinc coatings, but they are produced using hazardous chemicals, the development of \u201Cgreen\u201D technologies is a paramount purpose. Consequently, the corrosion behavior of zinc coatings subjected to a Cr3+ based passivating treatment, with and without sealing, was studied through EIS measurements in 0.5 M Na2SO4 solution. The analyses of the experimental data allowed inferring that the Cr3+-based conversion treatment with an adequate sealer provides good corrosionresistance and, coupled to an adequate painting system, could be a suitable alternative totraditional chromate coatings.","palabras_clave":"CORROSION |TRIVALENT CHROMIUM|CONVERSION LAYER|SEALING TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87977,"idioma_id":5,"titulo":"TRATAMIENTOS DE CONVERSIÓN ATÓXICOS Y ECO-COMPATIBLES PARA LA PROTECCIÓN DE ACERO ELECTROCINCADO","resumen":"The corrosion resistance of pure zinc coatings can beimproved through the application of suitable chemical passivationtreatments. Hexavalent chromium compounds have widely been usedto formulate conversion layers providing better anticorrosive protectionas well as anchorage properties to painting systems. However, takinginto account that they are produced using hazardous chemical ingredients,the development of alternative and \u201Cgreen\u201D technologies withequivalent protective performance is a paramount purpose of manyR&amp;D laboratories working around the world. In the present paper, thecorrosion behavior of zinc coatings obtained from free-cyanide alkalinebaths and latterly subjected to a Cr3+ based passivation treatment, with and without a sealing treatment, was studied. The experimental work involved electrochemical impedance spectroscopy measurements in 0.5 M Na2SO4 solution, surface microstructural and morphological characterization by electronic microscopy as well as chemical analysis by EDXS. The analysis and interpretation of all the data coming from these battery of tests allowed inferring that both the Cr3+ based conversion treatment + adequate sealer presented a good corrosion resistance and, therefore, they could be used as a none polluting nor toxic alternative to the traditional chromate coatings.","palabras_clave":"ZINC|CONVERSION TREATMENT|ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY|CORROSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87978,"idioma_id":4,"titulo":"Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions","resumen":"The feline immunodeficiency virus (FIV) envelope glycoprotein (Env) possesses a short cytoplasmic domain of 53 amino acids containing four highly conserved cysteines at Env positions 804, 811, 815 and 848. Since palmitoylation of transmembrane proteins occurs at or near the membrane anchor, we investigated whether cysteines 804, 811 and 815 are acylated and analyzed the relevance of these residues for Env functions. Replacement of cysteines 804, 811 and 815 individually or in combination by serine residues resulted in Env glycoproteins that were efficiently expressed and processed. However, mutations C804S and C811S reduced Env fusogenicity by 93% and 84%, respectively, compared with wild-type Env. By contrast, mutant C815S exhibited a fusogenic capacity representing 50% of the wild-type value. Remarkably, the double mutation C804S\/C811S abrogated both Env fusion activity and Env incorporation into virions. Finally, by means of Click chemistry assays we demonstrated that the four FIV Env cytoplasmic cysteines are palmitoylated.","palabras_clave":"FELINE IMMUNODEFICIENCY VIRUS|ENVELOPE GLYCOPROTEIN|FUSOGENIC ACTIVITY|PROTEIN PALMITOYLATION|CLICK CHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87979,"idioma_id":4,"titulo":"Trade-off between seed number and weight: influence of a grass-endophyte symbiosis","resumen":"Plant fitness is enhanced by resource allocation to seed number (offspring number) or weight (offspring survival). Besides,there is a well known trade-off in resource allocation between both traits. Symbiotic interactions can influence plant resourceallocation to reproduction, yet little research has been performed in this direction.We studied the consequences of a grass\u2013fungussymbiosis on the trade-off between seed number and weight, using Lolium multiflorum and the endophyte Neotyphodiumoccultans as our study system. In ecological terms, we experimentally removed N. occultans from L. multiflorum plants, andcompared reproductive allocation to seed number and weight in endophyte-symbiotic vs. non-symbiotic plants at differentlevels of nutrient availability (small pots vs. large pots). In evolutionary terms, we compared reproductive allocation betweensymbiotic vs. non-symbiotic plants for different host genotypes. All plants showed a negative association between seed numberand weight, once standardized for total reproductive biomass. Under high nutrient availability, endophyte-symbiotic plantsshowed higher seed weight than non-symbiotic plants for any seed number. However, no differences were observed under lownutrient availability. Endophyte influence also varied according to L. multiflorum genotype; specifically, endophyte-symbioticplants showed a lower slope in the relationship between seed number and weight than non-symbiotic plants for the \u2018Marshall\u2019genotype but no endophyte influence was found for the \u201CPampean\u201D genotype. The results implied a higher plasticity in seedweight and lower plasticity in seed number for symbiotic plants. Indeed, endophyte-symbiotic plants showed an overall lowerslope in the association between seed number and total reproductive biomass than non-symbiotic plants. Our results suggestthat N. occultans induces heavier seeds in L. multiflorum plants under environmental conditions favorable to plant growth orfor certain plant genotypes. We propose that symbiotic interactions may influence the evolution of seed number and weighttrade-off.","palabras_clave":"simbiosis|endofitos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87980,"idioma_id":4,"titulo":"Threshold modelling Lolium multiflorum seed germination: effects of Neotyphodium endophyte infection and storage environment","resumen":"Several forage species establish mutualistic associations with vertically-transmitted endophytic fungi thatimprove their fitness. However, the endophyte may be related to livestock toxicosis and hence ageing seedshas been used to remove the fungus since it loses viability before the seeds. The effect of endophyte on seedquality has rarely been studied. We conducted an experiment to study the relationship between the endophyteNeotyphodium occultans and seed germination characteristics in Lolium multiflorum. Infected and non-infectedseeds were stored under six different conditions and seed germination rate and viability were monitored over twoyears. Seed water content was evaluated and the ageing-time model was used to describe the dynamics of seed germination in relation to storage period. The model provided a good description of the seed germination, and parameters appear to work better when seed viability is affected. The endophyte not only affected negatively the seed viability but also the germination rate. Although the endophyte modified the water content, this effect was not associated with the negative effect on viability. Since non-toxic endophytes are being selected to improve forage grasses, further research should incorporate the endophyte viability dynamics in the population-based model to better predict both seed quality decay and endophyte losses.","palabras_clave":"endophyte|seed|storage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87981,"idioma_id":4,"titulo":"Mutualism effectiveness and vertical transmission of symbiotic fungal endophytes in response to host genetic background","resumen":"Certain species of the Pooideae subfamily develop stress tolerance and herbivory resistance through symbiosis with vertically transmitted, asexual fungi. This symbiosis is specific, and genetic factors modulate the compatibility between partners. Although gene flow is clearly a fitness trait in allogamous grasses, because it injects hybrid vigor and raw material for evolution, it could reduce compatibility and thus mutualism effectiveness. To explore the importance of host genetic background in modulating the performance of symbiosis, Lolium multiflorum plants, infected and noninfected with Neotyphodium occultans, were crossed with genetically distant plants of isolines (susceptible and resistant to diclofop-methyl herbicide) bred from two cultivars and exposed to stress. The endophyte improved seedling survival in genotypes susceptible to herbicide, while it had a negative effect on one of the genetically resistant crosses. Mutualism provided resistance to herbivory independently of the host genotype, but this effect vanished under stress. While no endophyte effect was observed on host reproductive success, it was increased by interpopulation plant crosses. Neither gene flow nor herbicide had an important impact on endophyte transmission. Host fitness improvements attributable to gene flow do not appear to result in direct conflict with mutualism while this seems to be an important mechanism for the ecological and contemporary evolution of the symbiotum.&nbsp;","palabras_clave":"environmental stress|genetic specificity|grassendophyte interaction|hybrid vigor"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87982,"idioma_id":4,"titulo":"Antioxidants in Festuca rubra L. seeds affected by the fungal symbiont Epichloë festucae","resumen":"Vertically transmitted fungal endophytes can be beneficial for host grasses.While the alkaloid-mediated mechanism for herbivore resistance has been widely studied, underlying physiological mechanisms for increased tolerance to abiotic stress remain scarcely explored. In this study we used three maternal lines of perennial grass Festuca rubra to examine the role of antioxidants in endophyte-mediated effects on seed viability over long-term storage. Uncolonized plants (E&#8722;) were generated by removing the endophyte from ramets of naturally endophyte-colonized (E+) plants. The E+ and E&#8722; ramets were planted in a common garden in Salamanca, Spain. Seeds produced in 2009, 2010 and 2011 were harvested at maturity, dried and stored at 10 °C until 2011 when we tested seed and endophyte viability, and measured antioxidants. Seed viability and &#945;-tocopherol antioxidant were negatively affected by the endophyte in two maternal lines. In these same lines, the endophyte viability was lowest at the longest storage time. In the maternal line that showed the highest negative effect of endophyte on seed viability, the pattern of glutathione was opposite to that observed for tocopherols since it was higher for E+ than for E&#8722; seeds. In all maternal lines, the glutathione half-cell reduction potential (EGSSG\/2GSH) and % glutathione disulphide (GSSG) increased with storage time but there was no clear pattern associated with endophyte symbiosis. Whether these parameters are good predictors of seed and endophyte longevity in storage and natural conditions should be further explored. &nbsp;","palabras_clave":"Symbiosis|Systemic endophytes|Red fescue|Cellular redox environment"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87983,"idioma_id":4,"titulo":"B cell response during protozoan parasite infections","resumen":"In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and\/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines\/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections.","palabras_clave":"B-cell|humoral response|Trypanosoma cruzi|polyclonal activation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87984,"idioma_id":4,"titulo":"FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival.","resumen":"B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbialinfection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that controlperipheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcgRIIb exhibit a massive expansionin peritoneal B1 cells, implicating this receptor in B1 cell homeostasis. In this study, we show that peritoneal B1 cells express thehighest levels of FcgRIIb among B cell subsets and are highly susceptible to FcgRIIb-mediated apoptosis. B1 cells upregulateFcgRIIb in response to innate signals, including CpG, and the B cell homeostatic cytokine BAFF efficiently protects activated B1cells from FcgRIIb-mediated apoptosis via receptor downregulation. BAFF-transgenic mice manifest an expansion of peritonealB1 cells that express lower levels of FcgRIIb and exhibit reduced susceptibility to apoptosis. Whereas both peritoneal B1 cellsfrom wild-type and BAFF-transgenic mice immunized with CpG exhibit an increase in FcgRIIb levels, this change is blunted inBAFF-transgenic animals. Our combined results demonstrate that FcgRIIb controls peritoneal B1 cell survival and this programcan be modulated by the BAFF signaling axis.","palabras_clave":"B1 cell|peritoneum|apoptosis|Fc receptor"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87985,"idioma_id":4,"titulo":"A GIS-BASED ASSESSMENT OF GROUNDWATER SUITABILITY FOR IRRIGATION PURPOSES IN FLAT AREAS OF THE WET PAMPA PLAIN, ARGENTINA","resumen":"The Pampa in Argentina is a large plain with a quite obvious dependence on agriculture,water availability and its quality. It is a sensitive environment due to weather changes and slope variations. Supplementary irrigation is a useful practice for compensating the production in the  zone. However, potential negative impacts of this type of irrigation in salinization and sodification of soils are evident. Most conventional methodologies for assessing water irrigation quality have difficulties in their application in the region because they do not adjust to the defined assumptions for them. Consequently, a new GIS-based methodology integrating multiparametric data was proposed for evaluating and delineating groundwater suitability zones for irrigation purposes in   flat areas. Hydrogeological surveys including water level measurements, groundwater samples for chemical analysis and electrical conductivity (EC) measurements were performed. The combination of EC, sodium adsorption ratio, residual sodium carbonate, slopes and hydraulic   gradient parameters generated an Irrigation Water Index (IWI). With the integration of the IWI 1 to 3 classes (categories of suitable waters for irrigation) and the aquifer thickness the Restricted Irrigation Water Index (RIWI) was obtained. The IWI´s index application showed that 61.3 % in the area has \u201CVery high\u201D to \u201CModerate\u201D potential for irrigation, while the 31.4% of it has unsuitable waters. Approximately, 46% of the tested area has high suitability for irrigation and moderate groundwater availability. This proposed methodology has advantages over traditional methods because it allows for better discrimination in homogeneous areas.","palabras_clave":"GIS|Groundwater|Hydrogeological information|Irrigation water suitability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87986,"idioma_id":5,"titulo":"Modelación geoespacial exploratoria en cuencas de llanura: caso de aplicación en la cuenca del Arroyo Dulce, Buenos Aires, Argentina","resumen":"Este trabajo presenta una evaluación de las técnicas y los procesos que pueden emplearse en la tarea de levantamiento y ajuste de geodatos y procesos de geomodelación asociados a la construcción de modelos espaciales con propósitos hidrológicos e hidrogeológicos. Igualmente se hace un análisis de la información y técnicas disponibles y su influencia en los resultados obtenidos. Se utilizó como información antecedente los modelos de elevación digital obtenidos del sensor SRTM y los elaborados a partir de las curvas de nivel obtenidas de las cartas topográficas del Instituto Geográfico Nacional, escala 1:50.000, a través de las técnicas TIN to Raster con corrección con la herramienta Arc Hydro y Topo to  Raster. Los resultados obtenidos fueron modelos geoespaciales tanto de superficie como de subsuelo de la cuenca del Arroyo Dulce. El uso de estas herramientas de modelación en conjunto con algoritmos modificados muestra su potencial para la obtención de modelos hidrológicos e hidrogeológicos.","palabras_clave":"modelación geoespacial|modelos de elevación digital|sistemas de información geográfica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87987,"idioma_id":4,"titulo":"Entamoeba histolytica Thioredoxin Reductase: Molecular and functional characterization of its atypical properties","resumen":"BackgroundEntamoeba histolytica, an intestinal protozoan that is the causative agent of amoebiasis, is exposed to elevated amounts of highly toxic reactive oxygen and nitrogen species during tissue invasion.  Thioredoxin reductase catalyzes the reversible transfer of reducing equivalents between NADPH and thioredoxin, a small protein that plays key metabolic functions in maintaining the intracellular redox balance.Methods  The present work deals with in vitro steady state kinetic studies aimed to reach a better understanding of the kinetic and structural properties of thioredoxin reductase from E. histolytica (EhTRXR). ResultsOur results support that native EhTRXR is a homodimeric covalent protein that is able to catalyze the NAD(P)H-dependent reduction of amoebic thioredoxins and S-nitrosothiols. In addition, the enzyme exhibited NAD(P)H dependent oxidase activity, which generates hydrogen peroxide from molecular oxygen. The enzyme can reduce compounds like methylene blue, quinones, ferricyanide or nitroderivatives; all alternative substrates displaying a relative high capacity to inhibit disulfide reductase activity of EhTRXR.Conclusions and General SignificanceInterestingly, EhTRXR exhibited kinetic and structural properties that differ from other low molecular weight TRXR. In vitro studies sustain the potentiality of EhTRXR as a molecular target for the rational design of new antiparasitic drugs. This idea is based on the versatile operability of the TRX system, which could play an important role in the parasite defense against reactive species. The latter should be critical during the extra intestinal phase of the amoebic infection. So far we know, this is the first in depth characterization of EhTRXR activity and functionality.","palabras_clave":"Entamoeba|Thioredoxin|S-nitrosothiol|Antioxidant|Reducing power"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87988,"idioma_id":4,"titulo":"Overview of plant-made vaccine antigens against malaria","resumen":"This paper is an overview of vaccine antigens against malaria produced in plants. Plant-based expression systems represent an interesting production platform due to their reduced manufacturing costs and high scalability. At present, different Plasmodium antigens and expression strategies have been optimized in plants. Furthermore, malaria antigens are one of the few examples of eukaryotic proteins with vaccine value expressed in plants, making plant-derived malaria antigens an interesting model to analyze. Up to now, malaria antigen expression in plants has allowed the complete synthesis of these vaccine antigens, which have been able to induce an active immune response in mice. Therefore, plant production platforms offer wonderful prospects for improving the access to malaria vaccines.                                ","palabras_clave":"Malaria|Plasmodium|plant-made antigen|plant expression systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87989,"idioma_id":4,"titulo":"A chloroplast-derived Toxoplasma gondii GRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice","resumen":"The parasitic protozoan Toxoplasma gondii, the causal agent of toxoplasmosis, can infect most mammals and birds. In human medicine, T. gondii can cause complications in pregnant women and immunodeficient individuals, while, in veterinary medicine, T. gondii infection has economic importance due to abortion and neonatal loss in livestock. Thus, the development of an effective anti-Toxoplasma vaccine would be of great value. In the present study, we analyzed the expression of T. gondii GRA4 antigen by chloroplast transformation (chlGRA4) in tobacco plants and evaluated the humoral and cellular responses and the grade of protection after oral administration of chlGRA4 in a murine model. The western blot analysis revealed a specific 34-kDa band mainly present in the insoluble fractions. The chlGRA4 accumulation levels were approximately 6 µg per gram of fresh weight (equivalent to 0.2% of total protein). Oral immunization with chlGRA4 resulted in a decrease of 59% in the brain cyst load of mice compared to control mice. ChlGRA4 immunization elicited both a mucosal immune response characterized by the production of specific IgA, and IFN-g, IL-4 and IL-10 secretion by mesenteric lymph node cells, and a systemic response in terms of GRA4-specific serum antibodies and secretion of IFN-g, IL-4 and IL-10 by splenocytes. Our results indicate that oral administration of chlGRA4 promotes the elicitation of both mucosal and systemic balanced Th1\/Th2 responses that control Toxoplasma infection, reducing parasite loads. ","palabras_clave":"Toxoplasma gondii|GRA4|chloroplast transformation|plant vaccine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87990,"idioma_id":4,"titulo":"Pink fairy armadillo meniscate burrows and ichnofabrics from Miocene and Holocene interdune deposits of Argentina: Palaeoenvironmental and palaeoecological significance","resumen":"The possible producer and environmental setting of large meniscate burrows (Nagtuichnus meuleni igen. and isp. nov.) occurring in late Miocene and Holocene aeolian deposits from Argentina are discussed. These are unbranched burrows with an uniform meniscate filling that range in width from 46 to 78 mm. N. meuleni distinguishing features are a filling composed of a discontinuous, outer massive layer between a central meniscate core and the excavation boundary, sets of parallel ridges in the external wall, and a particular outline plus the presence of paired pits in the concave surface of menisci (or hollows in the convex surface). The late Miocene lower member of the Río Negro Formation at La Lobería (Río Negro province) is interpreted as aeolian dune, damp interdune and dry interdune deposits. The Holocene sediments from Gran Salitral (southwestern La Pampa province) represent aeolian dune, wet interdune and dry interdune deposits. N. meuleni occurs only in damp and dry interdune deposits. The composite ichnofabric produced by N. meuleni in the Holocene of the Gran Salitral is composed of two suites of trace fossils. A former Skolithos suite includes Skolithos linearis, Taenidium barretti, Polykladichnus aragonensis and root traces developed in lacustrine calcareous mudstone deposits (wet interdune). This suite is overprinted by N. meuleni, with subordinate participation of S. linearis and root traces, composing the Nagtuichnus suite. The later suite is developed in brown silt and sand of dry interdune areas. The Nagtuichnus ichnofabric is considered indicative of damp to dry interdune facies of late Miocene to Holocene age. The burrow systems of the likely producers of the Holocene N. meuleni structures were studied in the field and in the laboratory. The candidates were selected from the extant local fauna of the Gran Salitral, including southern cavies (Microcavia australis, Rodentia), tuco-tucos (Ctenomys azarae, Rodentia), and pink fairy armadillos or pichiciegos (Chlamyphorus truncatus, Xenarthra). The most likely producer of N. meuleni are pichiciegos because they have fully subterranean habits and insectivorous diet involving the production of long, unbranched, horizontal burrows excavated in sand, which are mostly backfilled. In contrast to this, tuco-tucos and southern cavies, which are herbivores that forage aboveground, use their more permanent burrows for dwelling and reproduction. As observed in a live, captive-kept C. truncatus, the meniscate structure of the fill can be explained by the animal packing the excavated sand with its rump plate. This mechanism also results in a massive layer of sediment in the burrow fill. Other significant bioglyphs that are a sort of fingerprint of pichiciegos are the outline of menisci in cross-section (mimicking their rump plate) and pairs of rounded pits in the concave surface of menisci (probably tail traces).","palabras_clave":"NAGTUICHNUS MEULENI IGEN. AND ISP. NOV.|VERTEBRATE BURROWS|PINK FAIRY ARMADILLO|BIOGLYPHS|NEOICHNOLOGY|AEOLIAN FACIES|INTERDUNE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87991,"idioma_id":4,"titulo":"Detecting allocyclic signals in volcaniclastic fluvial successions: facies, architecture and stacking pattern from the Cretaceous of central Patagonia, Argentina","resumen":"The Castillo Formation and the overlying lower member of the Bajo Barreal Formation (Cretaceous) are the principal hydrocarbon-producing units of the San Jorge Basin, Patagonia, Argentina. They are mainly composed of sandstone lenses interbedded with finer-grained, tuffaceous, sheet-like strata. Both units record fluvial systems influenced by voluminous pyroclastic influx via ash-falls mainly from a western source. These fluvial systems drained from the west toward a non-marine depocenter located in the eastern part of the basin. The units were studied in the Sierra de San Bernardo, a NNW-SSE oriented fold and thrust belt located in the western sector of the basin. The objectives of this study were: (i) to assess the influence of allocyclic factors on fluvial dynamics and sedimentation, and (ii) to determine the possible link between changes in tephra reworking and configuration of channel belts. The methodology  included facies and architectural analyses, as well as determination of the stacking pattern of the channel deposits. The Castillo Formation represents permanent single-channel rivers with channel-margin bars.  Floodplains were commonly constructed from aqueous reworking of pyroclastic substrates (sheet-floods, debris-flows and shallow lacustrine sedimentation) and, to a lesser extent, by preservation of ash-fall  deposits. The lower member of the Bajo Barreal Formation generally records braided fluvial channel belts with a more variable water discharge and, in one locality, single-channeled rivers. Constructive  processes of the floodplains were similar to the underlying Castillo Formation, although other types of deposits were detected in lower proportions including hyperconcentrated flows and crevasse-splays. The  different pyroclastic sediment supply between both units explains the general evolution of the fluvial systems. The stacking patterns, which are a response to base-level changes, are probably associated with  the common tectonic activity recorded in the eastern part of the basin. Significant climatic changes are not detected during deposition of both units, although indicators of variability in water discharge  recognized in some paleochannels of the lower member of the Bajo Barreal Formation could be linked to seasonality in the catchments.","palabras_clave":"VOLCANICLASTIC FLUVIAL ENVIRONMENT|ALLOCYCLIC SIGNALS|CRETACEOUS|SAN JORGE BASIN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87992,"idioma_id":4,"titulo":"Chromium and titanium\/chromium-containing MCM-41 mesoporous silicates as promising catalysts for the photobleaching of azo dyes in aqueous suspensions. A multitechnique investigation","resumen":"Cr\/MCM-41 and TiO2\/Cr\/MCM-41 mesoporous silica were synthesized by the wet impregnation method. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS) and Electron Spin Resonance (ESR) techniques were employed for the nanocatalysts characterization and a comparison with previously reported results of UV - Vis diffuse reflectance spectroscopy (UV-vis DR), X-ray Diffraction (XRD) and N2 adsorption\/desorption analysis was carried out. It could be confirmed that the lower Cr loadings in the samples result in the increased presence of highly dispersed oxidized Cr species, which allows the desired heterojunction effect after the Ti loading and thehigh catalytic activity in the Acid Orange 7 (AO7) degradation. In this work, the analysis of the AO7 degradation progress by UV-vis and FT-IR spectroscopy has been made using the TiO2\/Cr\/MCM-41(3.5) as photocatalyst, under visible and UV-vis radiation. Short irradiation times resulted in a high degradation of the azo and naphthalene groups present in the AO7 dye. At longer irradiation times, when total discoloration of AO7 solution is obtained (&gt;97%), the biodegradability index (BOD5\/COD) reaches values greater than 0.40. This photocatalytic process could be used as a pre-treatment step before conventional biological treatment.","palabras_clave":"AZO-DYES|METALLIC SPECIES|PHOTOBLEACHING|BIODEGRADABILITY|MCM-41"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87993,"idioma_id":4,"titulo":"Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters","resumen":"&#947;-aminobutyric acid (GABA) transport and catabolism in Saccharomyces cerevisiae are subject to a complex transcriptional control that depends on the nutritional status of the cells. The expression of the genes that form the UGA regulon is inducible by GABA and sensitive to Nitrogen Catabolite Repression (NCR). GABA induction of these genes is mediated by Uga3 and Uga35\/Dal81 transcription factors whereas GATA factors are responsible for NCR. Here we show that all members of the UGA regulon share the activation mechanism. Our results show that both Uga3 and Uga35\/Dal81 interact with UGA genes in a GABA-dependent manner, and that they depend on each other for the interaction with their target promoters and the transcriptional activation. The typical DNA-binding domain Zn(II)2-Cys6 of Uga35\/Dal81 is unnecessary for its activity and Uga3 acts as a bridge between Uga35\/Dal81 and DNA. The trans-activation activity of the GATA factor Gln3 is exerted by its interaction with UGA promoters in response to GABA, indicating that Uga3, Uga35\/Dal81 and Gln3 all act in concert inducing the expression of UGA genes. So, some interplay between the factors responsible for GABA induction and those responsible for NCR in the regulation of the three UGA genes is here proposed.","palabras_clave":"TRANSCRIPTION FACTORS|UGA GENES|SACCHAROMYCES CEREVISIAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87994,"idioma_id":4,"titulo":"GABA induction of the Saccharomyces cerevisiae UGA4 gene depends on the quality of the carbon source: Role of the key transcription factors acting in this process","resumen":"Yeast cells are able to adapt their metabolism according to the quality of both carbon and nitrogen sources available in the environment. UGA4 gene encodes a permease capable of transporting &#947;-aminobutyric acid into the cells. Yeast uses this amino acid as a nitrogen source or as a carbon skeleton that enters the tricarboxylic acid cycle.  The quality of the carbon source modulates UGA4 expression through two parallel pathways, each one acting on different regulatory elements, the UASGATA and the UASGABA elements. In the presence of a fermentable carbon source, UGA4 expression is induced by GABA while in the presence of a non-fermentable carbon source this expression is GABA-independent.  The aim of this work was to study the mechanisms responsible for the differences in the profiles of UGA4 expression in both growth conditions.   We found that although the subcellular localization of Gln3 depends on the carbon source and UGA4 expression depends on Tor1 and Snf1, Gln3 localization does not depend on these kinases. We also found that the phosphorylation of Gln3 is mediated by two systems activated by a non-fermentable carbon source, involving the Snf1 kinase and an unidentified TORC1-regulated kinase. The activity of these kinases yields to different activities of this GATA factor being the activity of Gln3 phosphorylated by Snf1 higher than that of Gln3 phosphorylated by the unidentified kinase.  We also found that the activity of the main transcription factors responsible for UGA4 induction by GABA varies depending on the quality of the carbon source. In glucose, the negative GATA factor Dal80 binds to UGA4 promoter; only after the addition of the inducer, the positive factors Uga3, Dal81 and Gln3 interact with the promoter removing Dal80 leading to gene induction. In contrast, in acetate the negative GATA factor remains bound to UGA4 promoter under all the conditions assayed, the positive factors are not detected bound in any of these conditions and in consequence, UGA4 is not induced.","palabras_clave":"UGA4|CARBON REGULATION|GATA FACTORS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87995,"idioma_id":4,"titulo":"Using Continuum Level Density in the Pairing Hamiltonian: BCS and Exact Solutions","resumen":"Pairing plays a central role in nuclear systems. The simplest model for the pairing is the constant-pairing Hamiltonian. The aim&nbsp; of the present paper is to include the continuum single particle level density in the constant pairing Hamiltonian and tomake a comparison between the approximate BCS and the exact Richardson solutions.The continuum is introduced by using the continuum single particle level density. It is shown that the continuum makes an important contribution to the pairing parameter even in those case when the continuum is weakly populated.It is shown that while the approximate BCS solution depends on the model space the exact Richardson solution does not.","palabras_clave":"Pairing in the continuum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87996,"idioma_id":5,"titulo":"Catolicismo y sensibilidad antiburguesa. La Iglesia Católica en una era de desarrollo, 1955-1965","resumen":"Desde una perspectiva de historia social y cultural, el artículo revisa latransición hacia la década de 1960. Se concentra en el modo en que eldesarrollismo ejerció su influencia en el catolicismo a través de las nuevasprácticas sociales y culturales que trajo consigo, así como también através de la nueva sensibilidad antiburguesa a la que dio lugar","palabras_clave":"desarrollismo |catolicismo|cultura"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87997,"idioma_id":4,"titulo":"A fuzzy logic method to assess the relationship between landscape patterns and bird richenss of the Rolling Pampas","resumen":"The loss of biodiversity in productiveecosystems is a global concern of the last decades. TheRolling Pampas of Argentina is an intensively croppedregion that underwent important land use and landscapechange, with different impacts on biodiversity ofboth plants and animals. Land use type and habitatcomplexity are hypothesized to be the most importantfactors determining species richness in agro-ecosystems.But it is not easy to define these attributes in anunambiguous fashion, or determine their interactionsat different spatial scales. A fuzzy logic approachallows overcoming some of these problems by usinglinguistic variables and logic rules to relate them andformulate hypothesis. We constructed fuzzy logicmodels to study how bird species richness in theRolling Pampas is related to land use and habitatcomplexity, and how these variables interact at twospatial scales. Results showed that at the local scale,landscape complexity is the most important factordetermining species numbers; trees and bodies ofwater are the most influential complexities. The effectof local scale landscape attributes was modifieddepending on the context at broader scales, so thatagricultural sites were enriched when surrounded bymore favorable landscapes. There was a high dispersionin the predicted\/observed value relationship,indicating that landscape factors interact in morecomplex ways than those captured by the models weused. We suggest that the fuzzy logic approach issuitable for working with biological systems, and wediscuss the advantages and disadvantages of its use.","palabras_clave":"fuzzy logic|agroecosystems|bird richness"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87998,"idioma_id":4,"titulo":"Study of Canine Parvovirus evolution: Comparative analysis of full length VP2 gene sequences from Argentina and international field strains","resumen":"  The continuous emergence of new strains of  canine parvovirus (CPV), poorly protected by current vaccination,  is a concern among breeders, veterinarians, and  dog owners around the world. Therefore, the understanding  of the genetic variation in emerging CPV strains is crucial  for the design of disease control strategies, including vaccines.  In this paper, we obtained the sequences of the fulllength  gene encoding for the main capsid protein (VP2) of  11 canine parvovirus type 2 (CPV-2) Argentine representative  field strains, selected from a total of 75 positive  samples studied in our laboratory in the last 9 years. A  comparative sequence analysis was performed on 9 CPV-2c,  one CPV-2a, and one CPV-2b Argentine strains with respect  to international strains reported in the GenBank database. In  agreement with previous reports, a high degree of identity  was found among CPV-2c Argentine strains (99.6?100%  and 99.7?100% at nucleotide and amino acid levels,  respectively). However, the appearance of a new substitution  in the 440 position (T440A) in four CPV-2c Argentine  strains obtained after the year 2009 gives support to the  variability observed for this position located within the VP2,  three-fold spike. This is the first report on the genetic characterization  of the full-length VP2 gene of emerging CPV  strains in South America and shows that all the Argentine  CPV-2c isolates cluster together with European and North  American CPV-2c strains.","palabras_clave":"Canine parvovirus|VP2 full-length gene|CPV-2c variants|Sequence analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":87999,"idioma_id":4,"titulo":"Improved immune response to recombinant influenza nucleoprotein formulated with ISCOMATRIX","resumen":"Current   influenza vaccines elicit antibodies effective against homologous   strains, but new strategies are urgently needed for protection against   emerging epidemic or pandemic strains.&nbsp; Although influenza vaccine candidates based on the viral nucleoprotein (NP) or matrix protein   do not elicit sterilizing immunity, they have the advantage of inducing   immunity that may cover a larger number of viral strains. In this   study, recombinant NP produced in Escherichia coli, was purified and formulated in combination with the adjuvant ISCOMATRIX®.&nbsp; This   formulation increased a NP-specific immunity in mice, with a Th1   profile, and may constitute a promising low cost influenza vaccine   candidate, with ability to stimulate humoral and cellular immune   responses.   ","palabras_clave":"INFLUENZA|NUCLEOPROTEINA|ISCOMATRIX|ADJUVANTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88000,"idioma_id":4,"titulo":"Phylogeography of mitochondrial haplogroup D1: an early spread of subhaplogroup D1j from Central Argentina","resumen":"In the present study we analized the patterns of variation of haplogroup D1 in the central region of Argentina including new data and information published from other native populations of South America. We observed that the recently described subhaplogroup D1j, defined by the presence of additional transitions at np T152C\u2013C16242T\u2013T16311C, is present in high frequency in all the sampling places accross the provinces ofCórdoba, Santiago, and San Luis, a wide territory with marked geographic-ecological differences and different historical events. Almost 28% (107\/387) of the individuals sampled in the region belong to haplogroup D1, whereas more than 52% of them (56\/107) correspond to the subhaplogroup D1j. On the other hand, 12 individuals of this region present the mutation C16187T, that defines the recently named subhaplogroup D1g, and has been previously described in several populations of Patagonia and Tierra del Fuego.  Based on our results and additional data published by Motti et al. (2010), who also found high incidence of this lineage in several populations of northwestern Argentina, we postulate that the most likely origin and dispersal of the haplogroup D1j corresponds to the Sierras Pampeanas, a geographic region that occupies the center and part of the northwestern portion of Argentina. The extensive yet restricted geographical distribution, the relatively large internal diversity, and the absence or extremely low incidence of the subhaplogroup D1j in other regions of South America, suggest the existence of an ancient metapopulation covering the region of the Sierras Pampeanas, being this lineage its genetic signature.","palabras_clave":"MTDNA HVS-I|NATIVE AMERICANS|SIERRAS CENTRALES|SOUTHERN CONE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88001,"idioma_id":4,"titulo":"Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy","resumen":"Chagas disease, which is caused   by Trypanosoma cruzi (T. cruzi), remains a substantial public health   concern and an important cause of morbidity and mortality in Latin   America. T. cruzi infection causes an intense inflammatory response in   diverse tissues by triggering local expression of inflammatory   mediators, which results in the upregulation of the levels of cytokines   and chemokines, and important cardiac alterations in the host, being one   of the most characteristic damages of Chagas disease. Therefore,   controlling the inflammatory reaction becomes critical for the control   of the proliferation of the parasite and of the evolution of Chagas   disease. The nuclear receptors known as peroxisome   proliferator-activated receptors (PPARs) have emerged as key regulators   of lipid metabolism and inflammation. The precise role of PPAR ligands   in T. cruzi infection or in Chagas disease is poorly understood. This   review summarizes our knowledge about T. cruzi infection as well as   about the activation of PPARs and the potential role of their ligands in   the resolution of inflammation, with the aim to address a new   pharmacological approach to improve the host health.","palabras_clave":"TRYPANOSOMA CRUZI|PPAR|INFLAMMATION|HEART"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88002,"idioma_id":4,"titulo":"Laser fabrication of micropores and their integration to microfluidic platforms for DNA electrophoresis","resumen":"The work presents an alternative method for the manufacture of micropores by using the combination oflaser ablation and wet etching. The process of laser ablation was done on silicon (Si) wafers with siliconnitride (Si3N4) used as a sacrificial layer. The size of the pores was carefully controlled by following an optical technique. The method exhibits a series of advantages in relation micromachining techniques previously used. The fabricated pores were then integrated to polydimethylsiloxane (PDMS) microchannels, which constitutes a novel setup to be considered for microfluidic applications.Furthermore, as the system is addressed to study the electrically-driven transport of macromolecules, deoxyribonucleic acid (DNA) electrophoresis was performed in the fabricated microsystems to prove the principle. Also for these purposes, the electric field throughout the microchannel and pore region was studied in details by using numerical simulations.","palabras_clave":"LASER ABLATION|MICROPORE FABRICATION|PDMS MICROCHANNELS|ELECTROPHORESIS ON A CHIP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88003,"idioma_id":4,"titulo":"Observation of leaf-cutting ants foraging on wild mushrooms","resumen":"&nbsp;This study reports on the observation of an unusualbehavior in leaf-cutting ants: foraging on wild mushrooms.Acolonyof Acromyrmex lundi in Buenos Aires (Argentina)was observed intensively harvesting basidiomes (mushroom fructi&#64257;cations) of wild Agrocybe fungus developing on a treebark. Another colony maintained for a month in laboratoryconditions also accepted Agrocybe mushroom and incorpo-rated the cut bits into the fungus garden in the sameway as theydo with leaves. We recorded these events con&#64257;dent that theyopen a new perspective on the study of the feeding habits ofleaf-cutting ants as well as on the relationship between theirfungus garden and other organisms.","palabras_clave":"LEAF-CUTTING ANTS|FORAGING|FUNGI|ACROMYRMEX|WILD MUSHROOMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88004,"idioma_id":4,"titulo":"Characterization of a monolithic mesoporous carbon as diffusion layer for micro fuel cells application","resumen":"The preparation and characterization of a monolithic mesoporous carbon structure, which could be used as diffusion layer in PEM and DMPEM micro fuel cells, is described. Several characteristics of the monolithic carbon were studied, such as specific surface area, pore size distribution, bulk electrical resistivity, contact resistance with graphite plates, along with the wettability, imbibition and permeability of methanol aqueous solution. These properties were compared to those reported for commercial carbon paper and carbon cloth materials commonly used as diffusion layers in PEM fuel cells. The electrical properties of the mesoporous carbon meet the requirements to be employed as diffusion layers in PEM stacks assembled at pressures above 15 bar. The rapid spreading and imbibition of concentrated methanol solutions in the mesoporous carbon, as well as the permeability of the aqueous methanol through it, also make this mesostructured carbon a possible candidate for diffusion layer and catalyst support in passive direct methanol micro fuel cells.","palabras_clave":"Mesoporous carbon|Micro fuel cells|Diffusion layer"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88005,"idioma_id":4,"titulo":"Electrochemical characterization of PtRu nanoparticles supported on mesoporous carbon for methanol electrooxidation","resumen":"Nanoparticles of PtRu supported on mesoporous carbon were obtained by the impregnation and reduction method with NaBH 4. The high-surface-area mesoporous carbon was obtained by carbonization of a resorcinol-formaldehyde polymer with a cationic polyelectrolyte as a soft template. Surface characterization performed by transmission electron microscopy and powder X-ray diffraction showed a homogeneous distribution and high dispersion of metal particles. The PtRu catalyst shows an electrochemical active surface area, determined by CO stripping, 45% higher than PtRu catalyst synthesized by the same method on Vulcan. This translated in a 25% increase in the methanol oxidation current as well as a lower poisoning rate and higher turnover frequency, as was assessed by cyclic voltammetry and chronoamperometry. Differential electrochemical mass spectroscopy indicated an 8% higher conversion efficiency of methanol to CO 2, demonstrating the benefits of using a mesoporous carbon as catalyst support.","palabras_clave":"Pt-Ru nanoparticles|Methanol electrooxidation|Mesoporous carbon|fferential electrochemical mass spectrometry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88006,"idioma_id":4,"titulo":"Mesoporous Pt electrocatalyst for methanol tolerant cathodes of DMFC","resumen":"High activity mesoporous Pt electrocatalyst, having 2D-hexagonal mesostructure, was synthesized using a triblock poly(ethylene oxide)-b?poly(propylene oxide)-b?poly(ethylene oxide) copolymer (Pluronic F127®) template. The catalyst was characterized for the oxygen reduction reaction (ORR) in a rotating ring disk electrode (RRDE) configuration, obtaining a high efficiency of conversion to H2O. The formation of H2O2 during the ORR was low and a change in Tafel slope analysis indicated a change in the reaction mechanism with temperature. It was found, through differential electrochemical mass spectrometry (DEMS) analysis, that the mesoporous Pt catalysts exhibit a high methanol to CO2 conversion efficiency and high tolerance to CO poisoning. The procedure described in this work for preparing mesoporous Pt catalyst by electrodeposition provides a simple method for the generation of high-performance cathodes for direct methanol PEM fuel cells.®) template. The catalyst was characterized for the oxygen reduction reaction (ORR) in a rotating ring disk electrode (RRDE) configuration, obtaining a high efficiency of conversion to H2O. The formation of H2O2 during the ORR was low and a change in Tafel slope analysis indicated a change in the reaction mechanism with temperature. It was found, through differential electrochemical mass spectrometry (DEMS) analysis, that the mesoporous Pt catalysts exhibit a high methanol to CO2 conversion efficiency and high tolerance to CO poisoning. The procedure described in this work for preparing mesoporous Pt catalyst by electrodeposition provides a simple method for the generation of high-performance cathodes for direct methanol PEM fuel cells.","palabras_clave":"fuel cells|mesoporous Pt|electroreduction|methanol"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88007,"idioma_id":5,"titulo":"Advances in the development of vaccines for bovine neosporosis","resumen":"La neosporosis es una enfermedad que ocasiona abortos en bovinos y está causada por un protozoo intracelular obligado denominado Neospora caninum. Las graves pérdidas económicas que provoca en los sistemas de producción de bovinos justifica la necesidad de avanzar en el desarrollo de vacunas. La resistencia a parásitos Apicomplexa está asociada a una respuesta inmune T helper 1 mediada por linfocitos T CD4 citotóxicos y a la producción de interferón-gamma, interleuquina-12, factor de necrosis tumoral e inmunoglobulina G2. La disminuciónde la transmisión vertical en las sucesivas preñeces y el bajo nivel de repetición de abortos en animales infectados sugieren la existencia de mecanismos inmunitarios de protección. Hasta el momento se conoce que la inoculación pre-servicio con taquizoítos vivos protege contra la infección y el aborto. Los antecedentes de desarrollo de vacunas vivas contra otros protozoos estimulan a los investigadores a continuar en la búsqueda de una vacuna de este tipo contra N. caninum de buena eficacia. Por otra parte, una vacuna inactivada, aun con una baja eficacia, es útil en la prevención del aborto en aquellos establecimientos donde la enfermedad es epizoótica.Una vacuna contra la neosporosis debería evitar el aborto, la transmisión transplacental y la persistencia de la infección. Este trabajo menciona los diversos tipos de vacunas que han sido evaluados hasta el momento, incluyendo inmunógenos inactivos, taquizoítos vivos, antígenos recombinantes y vacunas en vectores.&nbsp;","palabras_clave":"Neospora caninum|bovines|abortion|vaccine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88008,"idioma_id":4,"titulo":"Clinical and reproductive consequences of using BVDV contaminated semen in artificial insemination in a beef herd in Argentina","resumen":"The current report was prompted by an atypical outbreak of mucosal disease that occurred in a beef herd in the southwestern part of Buenos Aires Province, Argentina, where a total of 9\/41 (21.9%) yearling bulls died. Blood samples from 73 bulls and 189 heifers were tested for evidence of persistent BVDV infection with Bovine Viral Diarrhea Virus (BVDV). Non-cytopathic BVDV was isolated from 7 (9.6%) 24- to 36-month-old bulls, and 3 (1.6%) 36-month-old heifers. Non-cytopathic BVDV was also detected in the seminal plasma of three of six persistently infected (PI) bulls. Furthermore, a 171 bp genomic fragment of BVDV was consistently detected by nested RT-PCR in one of the two samples of the commercial semen used for artificial insemination, indicating that this semen could be a possible source of infection for the whole herd. To evaluate the possible reproductive consequences of PI heifers and bulls, ovaries and semen were obtained from PI cattle for in vitro assays. The in vitro fertilization of oocytes with semen from PI bulls was associated with decreased cleavage and embryo development rates. Additionally, non-cytopathic BVDV was isolated from the follicular fluid of PI heifers. Genetic typing revealed that all isolates BVDV from the present study had a high percentage of homology and that all of the fragments from the RT-PCR clearly fit with the BVDV 1b cluster. These findings confirm the negative impact that BVDV can have on the reproductive performance of cattle and the importance of applying the proper sanitary controls to minimize the risk of BVDV infection.","palabras_clave":"BVDV|Mucosal disease|Persistent infection|Bovine semen"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88009,"idioma_id":4,"titulo":"Genomic analysis of bovine herpesvirus type 4 (BoHV-4) from Argentina: high genetic variability and novel phylogenetic groups","resumen":"Bovine herpesvirus 4 (BoHV-4) is a g-herpesvirus that has been isolated both from apparently healthy animals and from cattle with a variety of clinical signs, including post- partum endometritis and abortion. BoHV-4 causes either a persistent or a latent infection in cells of the monocyte\/macrophage lineage. Two groups of BoVH-4 strains have been defined based on their restriction patterns: the Movar-like strains (European prototype) and the DN 599-like strains (American prototype). The purpose of the present study was to genetically characterize wild type BoHV-4 strains isolated from vaginal discharges of aborted cows in Argentina. The virus was identified by isolation and nested PCR in all vaginal discharge samples from aborted cows, either as a sole agent or in association with other pathogens. Restriction enzyme profiling and phylogenetic analysis demonstrated that there is a high genetic variability among the studied field isolates. The existence of three groups of strains, which were designated as genotypes 1, 2 and 3, is described. Genotypes 1 and 2 possibly correspond to the Movar-like and DN 599-like groups, respectively, whereas Genotype 3 corresponds to a novel group. Two viral strains did not cluster into any of these three groups, indicating that other genotypes could be circulating in Argentina. These results suggest a complex epidemiological background for the Argentinean BoHV-4 strains, probably influenced by independent events of genetic drift. This hypothesis cannot be rejected based on the available data. However, there is no direct evidence supporting this possibility. Thus, it seems speculative to suggest that interspecific jumps are responsible for the observed phylogenetic grouping. On the other hand, our analyses suggest a geographical structure for the observed viral genotypes, since genotypes 1 and 2 included the European (Movar-like) and American (DN599-like) reference strains, respectively. Geographic dispersion is known to be a driver of herpes viruses diversification, and independent evolution in geographical isolated places ensures the emergence of particular mutations in each location due to genetic drift (Compans, 2007; Zong et al., 1999). Therefore, at this point, the genetic drift hypothesis is the one that requires less ad-hoc considerations and thus, to our understanding, is the one that fits to the findings from this study. The involvement of this genetic variability in the detection and pathogenesis of BoHV-4 remains to be investigated. g-herpesvirus that has been isolated both from apparently healthy animals and from cattle with a variety of clinical signs, including post- partum endometritis and abortion. BoHV-4 causes either a persistent or a latent infection in cells of the monocyte\/macrophage lineage. Two groups of BoVH-4 strains have been defined based on their restriction patterns: the Movar-like strains (European prototype) and the DN 599-like strains (American prototype). The purpose of the present study was to genetically characterize wild type BoHV-4 strains isolated from vaginal discharges of aborted cows in Argentina. The virus was identified by isolation and nested PCR in all vaginal discharge samples from aborted cows, either as a sole agent or in association with other pathogens. Restriction enzyme profiling and phylogenetic analysis demonstrated that there is a high genetic variability among the studied field isolates. The existence of three groups of strains, which were designated as genotypes 1, 2 and 3, is described. Genotypes 1 and 2 possibly correspond to the Movar-like and DN 599-like groups, respectively, whereas Genotype 3 corresponds to a novel group. Two viral strains did not cluster into any of these three groups, indicating that other genotypes could be circulating in Argentina. These results suggest a complex epidemiological background for the Argentinean BoHV-4 strains, probably influenced by independent events of genetic drift. This hypothesis cannot be rejected based on the available data. However, there is no direct evidence supporting this possibility. Thus, it seems speculative to suggest that interspecific jumps are responsible for the observed phylogenetic grouping. On the other hand, our analyses suggest a geographical structure for the observed viral genotypes, since genotypes 1 and 2 included the European (Movar-like) and American (DN599-like) reference strains, respectively. Geographic dispersion is known to be a driver of herpes viruses diversification, and independent evolution in geographical isolated places ensures the emergence of particular mutations in each location due to genetic drift (Compans, 2007; Zong et al., 1999). Therefore, at this point, the genetic drift hypothesis is the one that requires less ad-hoc considerations and thus, to our understanding, is the one that fits to the findings from this study. The involvement of this genetic variability in the detection and pathogenesis of BoHV-4 remains to be investigated. ","palabras_clave":"Bovine herpesvirus type 4|Aborted cows|Phylogenetic analysis|Restriction endonucleases"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88010,"idioma_id":4,"titulo":"Safety and efficacy of an E2 glycoprotein subunit vaccine produced in mammalian cells to prevent experimental infection with bovine viral diarrhoea virus in cattle","resumen":"AbstractBovine viral diarrhea (BVD) infection caused by bovine viral diarrhea virus (BVDV), a Pestivirus of the Flaviviridae family, is an important cause of morbidity, mortality and economical losses in cattle worldwide. E2 protein is the major glycoprotein of BVDV envelope and the main target for neutralising antibodies (NAbs). Different studies on protection against BVDV infection have focused on E2, supporting its putative use in subunit vaccines. A truncated version of type 1a BVDV E2 (tE2) expressed in mammalian cells was used to formulate an experimental oleous monovalent vaccine. Immunogenicity was studied through immunisation of guinea pigs and followed by trials in cattle. Calves of 8-12&nbsp;months were vaccinated, twice with a 4&nbsp;week interval, with either a tE2 subunit vaccine (n&#8201;=&#8201;8), a whole virus inactivated vaccine (n&#8201;=&#8201;8) or left untreated as negative control group (n&#8201;=&#8201;8). Four weeks after the last immunisation the animals were experimentally challenged intranasally with a non-cythopathic BVDV strain. Following challenge, BVDV was isolated from all unvaccinated animals, while 6 out of 8 animals vaccinated with tE2 showed complete virological protection indicating that the tE2 vaccine presented a similar performance to a satisfactory whole virus inactivated vaccine.","palabras_clave":"VDVB|Vaccine|mamalian cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88011,"idioma_id":4,"titulo":"Bovine rotavirus strains circulating in beef and dairy herds in Argentina from 2004 to 2010","resumen":"Bovine Group A Rotavirus (RVA) is one of the main causes of neonatal calf diarrhea worldwide. The present study reports the genotyping of bovine RVA strains circulating in Argentinean cattle from 2004 to 2010. Additionally, a new set of typing primers was designed and tested to differentiate between G8 and G6 (lineage III and IV) RVA strains.    Bovine RVA was detected in 30% (435\/1462) of the tested samples, corresponding to 49% (207\/423) of the studied outbreaks with a similar detection rates in beef (53%; 67\/127) and dairy herds (52%; 65\/126). The RVA strains circulating in Argentinean cattle belonged to the common bovine genotypes G6 (lineages III and IV), G8, G10, P[5] and P[11]. A different RVA G\/P-genotype distribution was found between the exploitation types, with the combination G6(IV)P[5] being by fare the most prevalent RVA strain in beef herds (58%), whereas a more even distribution of G6(III)P[11] (15%), G10P[11] (17%), G6(IV)P[5] (14%), and G6(IV)P[11] (6%) RVA strains was detected in dairy herds. G8 RVA strains were found in two dairy farms in calves co-infected with G8+G6(III)P[11]. A high percentage of co-infections and co-circulation of RVA strains with different genotypes during the same outbreak were registered in both exploitation types (20% of the outbreaks from beef herds and 23% from dairy herds), indicating a potential environment for reassortment. This finding is significant because G10P[11] and G6(III)P[11] strains may possess zoonotic potential. Continuous surveillance of the RVA strains circulating in livestock provides valuable information for a better understanding of rotavirus ecology and epidemiology.","palabras_clave":"Rotavirus|Bovine|Diarrhea|Dairy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88012,"idioma_id":4,"titulo":"In vitro replication of bovine herpesvirus types 1 and 5","resumen":"The aim of this work was to study the in vitro replication of bovine herpesvirus types 1 and 5 (BoHV-1 and 5) at the beginning and end of the logarithmic growth phase of Madin-Darby Bovine Kidney (MDBK) cells. The replication kinetics and size of lysis and infection plaques of the field isolates 09\/210 (BoHV-1) and 97\/613 (BoHV-5) and the reference strains BoHV-1.1 Los Angeles 38 (LA38), BoHV-1.1 Cooper, BoHV-5a N569 and BoHV-5b A663 were evaluated. The highest mean virus titre was recorded for N569, followed by LA38 and 97\/613. For most of the viruses, the virus titre values increased from 24h post-infection (hpi) up to 48hpi and then, they remained unchanged up to 72hpi. However, the virus titre for 09\/210 was significantly lower and a slight, steady increase was observed from 24 to 72hpi. Furthermore, the largest lysis and infection plaques were recorded for 97\/613 and LA38, respectively. According to this work, it is evident that there is a relationship between the replication of BoHV and the multiplication stage of MDBK cells. The results of this study contribute to the understanding of the replication behaviour in cell cultures of several strains of BoHV, which is critical for the rational design of in vitro experiments and vaccine production.","palabras_clave":"MOI multiplicity of infection|Herpesvirus|Cell culture|Viral replication| In vitro kinetics|Argentinean field strains|Cattle| BoHV bovine herpesvirus|hpi|hours post-infection|LA38; Los Angeles 38|MDBK; Madin-Darby Bovine Kidney cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88013,"idioma_id":5,"titulo":"Efectos de los productos de glicación avanzada (ages) y alendronato sobre el desarrollo osteoclástico: posibles mecanismos de acción","resumen":"Introducción: En la Diabetes Mellitus se ha descripto un incremento en el riesgo de fracturas, las cuales podrían asociarse a la acumulación de productos de glicación avanzada (AGEs) que alteran la función de los osteoclastos (Oc), células gigantes multinucleadas encargadas de resorber el hueso. Los bifosfonatos (BP), drogas ampliamente usadas en enfermedades óseas, inhiben la actividad resortiva de los Oc, aunque su uso en pacientes diabéticos es controversial.Objetivo: Estudiar el efecto de AGEs y alendronato sobre el desarrollo de Oc en cultivo, así como los posibles mecanismos involucrados en la acción de estos agentes.Materiales y Métodos: Se cocultivaron macrófagos Raw264.7 y osteoblastos UMR-106 durante 8 días, con BSA o AGE (50-200 &#956;g\/ml), con o sin alendronato (10-8\u201310-4M). Se evaluó el efecto de estas condiciones de cultivo sobre la formación de Oc (número de los mismos, y actividad de fosfatasa ácida tartrato-resistente [TRAP]), la expresión de RAGE (Receptor de AGEs) en los Oc, y la expresión del ligando de RANK (RANKL) en los osteoblastos por inmunofluorescencia indirecta.Resultados: Los AGEs (50-200 &#956;g\/ml) inhibieron en forma dosis-dependiente la TRAP (10-30 %) y el número de osteoclastos generados (55 %), similarmente a lo inducido por bajas dosis de alendronato (10-8M\u201310-6M). La coincubación de bajas dosis de alendronato con 100 &#956;g\/ml de AGEs no indujo una inhibición adicional a la de los AGEs sobre la actividad de TRAP o el número de Oc. Altos niveles de alendronato (10-5M\u201310-4M) inhibieron la actividad TRAP (20-25 % respecto a BSA y 17 % respecto de AGEs), así como el número de Oc desarrollados en presencia de AGEs (16 % con respecto a AGEs).Los Oc incubados en presencia de 100 &#956;g\/ml AGEs mostraron un incremento significativo en la expresión de RAGE (152 % respecto de BSA), situación similar a la observada postincubación con alendronato 10-8M (130 % respecto de BSA). Por el contrario, altas dosis de alendronato (10-5M) no modificaron la expresión del RAGE en los cocultivos incubados con BSA (95 % respecto de BSA). Por otro lado, bajas dosis de alendronato en presencia de AGEs no alteraron la \u201Cup-regulation\u201D del RAGE inducida por los AGEs (145 % respecto de BSA). Sin embargo, cuando los Oc se incubaron con AGEs y Ale 10-5M, esta dosis del bifosfonato bloqueó el efecto estimulante de los AGEs sobre la expresión de RAGE (105 % respecto de BSA).La incubación con 100 &#956;g\/ml AGE produjo una inhibición (50 % respecto de BSA), en la expresión del RANKL en los osteoblastos. El alendronato (10-8M\u201310-5M) indujo también una inhibición del RANKL en forma dosis dependiente (65-47 % respecto de BSA). Por otro lado en presencia de AGEs, el alendronato (10-8M\u201310-5M) no modificó la inhibición de la expresión del RANKL inducida por los AGEs (59-45 % del BSA).Conclusiones: Los AGEs y el alendronato inhiben el número y diferenciación de Oc en cultivo, con un efecto aditivo entre ambos a altas concentraciones de alendronato. También reducen la expresión de RANKL en osteoblastos, lo cual podría explicar parcialmente sus efectos sobre el reclutamiento y la maduración de Oc. Los AGEs y bajas dosis de alendronato aumentan la expresión de RAGE en Oc","palabras_clave":"Diabetes Mellitus|Productos de Glicación Avanzada|Bisfosfonatos, |Osteoclastos."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88014,"idioma_id":5,"titulo":"MONITOREO DEL GLACIAR HORCONES INFERIOR Y SUS TERMOKARST, ANTES Y DURANTE EL SURGE DE 2003-2006. ANDES CENTRALES ARGENTINOS","resumen":"This work analyses the temporal evolution of thermokarst and their relationship to the surges in a reconstituted debris covered glacier. The glacier Horcones Inferior is located at Lat 32º 41 S and Long 69º 57 W in the Provincial Park Aconcagua, Mendoza, Argentina, on the foot of the Aconcagua massif. The study and monitoring of the thermokarst was carried out applying indirect methods using Landsat and Aster images from 1997-2006. Detected percentages of thermokarst, in relation to the total glacial area, showed that they varied between 4.3% to 0% at the end of the surge event. The registered speeds of the glacier -on the glacial surface- reached averages of between 0.4 and 12 m\/d. This methodology, with historical images from archives, represents a fundamental tool to separate catastrophic and non-catastrophic glacial flow periods","palabras_clave":"SURGING GLACIER|TERMOKARST|IMAGENES SATELITALES|ANDES CENTRALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88015,"idioma_id":4,"titulo":"Effects of X-rays on Tuta absoluta for use in inherited sterility programmes","resumen":"Tuta absoluta is a key pest of tomato crops originating from South America. The consequences of X-radiation on this species were studied under laboratory controlled conditions. The effect of radiation on adult  emergence was evaluated exposing male and female pupae to increasing X-rays. Adult emergence decreased as doses of X-radiation increased, with the appearance of deformities such as malformed wings and bent legs at doses C350 Gy. Besides, males and females obtained from irradiated pupae were out crossed with untreated counterparts to explore the effects of X-radiation on inherited sterility. (a) Irradiated male 9 untreated female crosses. Both fecundity and fertility of the untreated females were reduced by radiation, and the effect was stronger as the doses increased.  Neither the longevity of parental males and F1 adults nor the sex ratios of the F1 and F2 generations were affected by X-radiation (F1 and F2: first and second generation of descendants of irradiated adults). Inherited sterility effects were manifested by a significant reduction in the F1 fecundity,F1 fertility, and the amount of larvae and pupae Produced. Doses of 200-250 Gy could be used to induce inherited sterility  in T. absoluta males. (b) Untreated male 9 irradiated female crosses. The minimum dose at which irradiated females were completely sterile was 200 Gy. The present study is the first study in T. absoluta that provides the starting point for implementing the inherited sterility in this species.","palabras_clave":"SOUT AMERICAN TOMATO PINWORM|X-RADIATION|INHERITED STERILITY|SUBLETHAL EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88016,"idioma_id":4,"titulo":"Rearing of the fruit fly parasitoid Diachasmimorpha longicaudata (Hymenoptera: Braconidae) on X-ray irradiated larvae of Ceratitis capitata (Diptera: Tephritidae)","resumen":"We evaluated the effects of X-ray irradiation on larvae of Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), with the aim of finding a treatment that prevented adult fly emergence, yet did not adversely affect larval quality as rearing hosts for the parasitoid Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Ichneumonidae). Two experiments were carried out. In the first experiment, small numbers of larvae were held in Petri dishes with and without small amounts of rearing media and then irradiated with doses of X-rays ranging from 0 to 8333.6 R (equivalent to 80 Gy). In the second experiment, higher numbers of larvae were held in a manner resembling mass-rearing conditions, and were then irradiated with X-rays ranging from 0 to 10,417 R (equivalent to 100 Gy). In both experiments, the only factor that significantly affected fly emergence was irradiation of larvae. Fly emergence decreased markedly as the irradiation dose increased, and complete suppression of fly emergence was achieved at 6250.2 R (equivalent to 60 Gy) when larvae were irradiated in small batches with or without rearing media. Irradiation also affected the fertility of those flies that did emerge following treatment. In the second experiment, we found the parasitoids reared from irradiated larvae produced a higher parasitism rate and a higher number of female offspring than did parasitoids reared from control (non-irradiated) larvae. Mean fecundity of F1 parasitoids reared from irradiated larvae were affected positively by irradiation only at the 8333.6 R (80 Gy) dose. Our results show that X-ray irradiation can be used to inhibit fruit fly adult emergence and that irradiated larvae are at least as good a rearing substrate as non-irradiated larvae. Future studies should focus on the adjustment of our findings to a mass-rearing scale.","palabras_clave":"DIACHASMIMORPHA LONGICAUDATA|CERATITIS CAPITATA|X-RAY|PARASITOIDS REARING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88017,"idioma_id":4,"titulo":"Analysis of soluble proteins\/aggregates derived from gluten-emulsifiers systems","resumen":"According to their amphiphilic nature, emulsifiers as Sodium Stearoyl Lactylate (SSL) and Diacetyl Tartaric Acid Esters of Monoglycerides (DATEM) favor interactions between dough components, although the mechanisms of action are not fully elucidated. There is quite information about the nature of emulsifier\u2013gluten protein interaction and its consequence in breadmaking quality, but no reports were found about structural changes in gluten proteins produced by SSL and DATEM and their influence in aggregation\u2013disaggregation gluten protein phenomena. For this reason the aim of this work was to investigate changes on gluten protein structure induced by SSL and DATEM; through the analysis of the nature of soluble aggregates by different SDS-PAGE techniques, and gliadins and glutenins extracted from gluten samples by RP-HPLC. At 1% level, SSL allowed the solubilization of a large proportion of high molecular mass aggregates, suggesting that at this high level, this emulsifier cause changes in native gluten protein network. Nevertheless, no significant differences in the protein quantity extracted of the distinct gliadins and glutenins were observed. On the other hand, the emulsifier SSL at 0.5% (w\/w) level also allowed the extraction of a high percentage of &#947;- gliadins and low molecular weight glutenins in comparison with gluten and gluten-DATEM samples. In conclusion distinct quantity and quality of gliadins and glutenins were extracted from gluten samples, depending on the level and the chemical structure of each emulsifier","palabras_clave":"Gluten proteins|Gliadins|Glutenins|Emulsifiers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88018,"idioma_id":4,"titulo":"USE OF ENZYMES TO MINIMIZE DOUGH FREEZING DAMAGE","resumen":"The purpose of this investigation was to study the effect pentosanase (Pn), glucose oxidase (Gox) and transglutaminase (TG) on frozen dough (-18 °C) and their influence on minimizing the damage caused by frozen storage. Bread characteristics were analyzed day 0, and after 3 and 9 weeks of frozen storage for specific loaf volume, crust color, crumb texture and structure. Dough expansion capacity and dough stickiness, extensibility and viscoelasticity were determined. Frozen dough with high level of Gox developed greater bread volume regarding control dough (without enzyme). Damage percentage caused by frozen storage in Gox samples was lower than control samples indicating that Gox increased the dough strength and counteracted the depolymerization effect of gluten as consequence of ice crystal formation and the release of reducing substances by yeast cells dead during freezing. Samples with Pn developed high bread volume after 9 weeks of frozen storage, explained by the formation of smaller pentosans, as a result of Pn enzyme action, which locate in protein-starch-CO2 matrix interfaces, increasing their expansion capacity without gas loss and thus allowing a higher expansion during proofing. Only the intermediate level of TG presented higher bread volume from frozen dough than control. The new isopeptidic bonds introduced by TG in the gluten proteins helped to mitigate the damage caused by dough freezing.","palabras_clave":"frozen dough|transglutaminase|pentosanase|glucose oxidase"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88019,"idioma_id":4,"titulo":"In vitro effect of methyl farnesoate on the vitellogenin content of ovary and hepatopancreas, in the crayfish Cherax quadricarinatus","resumen":"Vitellogenin levels were determined in pieces of either ovary or hepatopancreas taken for females of the crayfish Cherax quadricarinatus during both early pre-reproductive and reproductive periods, and exposed in vitro to 0.15, 1.5, or 15 uM of the juvenoid methyl farnesoate (MF). A significant accumulation of vitellogenin was seen in ovaries treated with 15 uM of MF during the early pre-reproductive period. Besides, protein synthesis, measured post-reproductive periods and exposed to 15 uM of MF. On the other hand, no stimulating effect of MF on the vitellogenin content of the hepatopancreas was seen in any periods. These results, taken together, support the hypothesis of the endogenous vitellogenin synthesis stimulated by MF during the early ovarian maturation. However, this hormone was not able to stimulate vitellogenin synthesis in the ovary during the reproductive period.","palabras_clave":"JUVENOIDS|CRUSTACEANS|REPRODUCTION|INDUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88020,"idioma_id":4,"titulo":"Paleoseismicity and seismic hazard in southern Patagonia (Argentina-Chile; 50º-55ºS); the role of the Magallanes-Fagnano transform fault","resumen":"Tierra del Fuego is an island in southernmost South America shared by Chile and Argentina. Three major cities add to a permanent population of 300,000, rapidly growing through immigration, and a touristic influx in the order of 200,000 annually. Tierra del Fuego is a seismic region. Instrumental records exist of four earthquakes of magnitude between 7.0 (two events) and 7.8 (two events) since 1949, and low intensity events are felt by the population every couple of years. The Magallanes-Fagnano (MF) transform fault, which crosses the island with an east-west trend, is recognized as a seismogenic source. Widely published calculations for the two M = 7.8 seismic events appear to indicate, however, that there might be another source in northern Tierra del Fuego island. This paper argues that the MF fault is the only significant source of earthquakes in this region, accounting for all the high-magnitude (instrumental and preinstrumental) seismic events. In addition it presents evidence for coseismic deformation in strandplains located at more than 300 km from the trace of the MF fault, in support for high-magnitude seismicity affecting Tierra del Fuego throughout the Holocene.","palabras_clave":"PALEOSISMOLOGY|SEISMIC HAZARD|CRUSTAL SEISMICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88021,"idioma_id":4,"titulo":"Heavy metals concentration in soft tissues of the burrowing crab, Neohelice granulata, in the Bahía Blanca estuary, Argentina","resumen":"Copper (Cu), cadmium(Cd), and chromium (Cr)in soft tissues of male and female burrowing crab Neohelice granulate, as well as their eggs, were measured in two different locations in the Bah&#305;´a Blanca estuary, a moderately polluted ecosystem, from October 2008 to August 2009.Differences between sexes, sites, and seasonality were assessed. Furthermore, metal levels in eggs were compared with metal levels in female crabs. The results showed no significant differences for Cu and Cd between sexes (Student t test p[0.25 for both sites) and sites (two-way analysis of variance: Cu p = 0.82 and Cd p = 0.29). Nevertheless,seasonality was found, with winter having significantly lower concentrations for both metals. The range of Cu concentrations was between 96.92 and 152.18 lg g-1 dry weight (dw), and the range of Cd concentrations was between 6.09 and 10.41 lg g-1 dw. Cr concentrations could not be assessed because most of the values were lower than the detection limit. Although heavy metals in sediments were not measured in this study, a bioaccumulation process may be occurring for Cd because levels found during the entire sampling period were greater than levels in sediment from previous years. For Cu, a regulation process may beoccurring considering that this is an essential metal and levels of Cu in N. granulata found in this study were between 1 and 2 orders of magnitude greater than levels in sediments.Finally, Cu and Cd levels in eggs were detectable, but they were lower than levels in female crabs. The importance of these findings is linked to the fact that metal accumulation seems to be occurring before hatch. The presence of heavy metals in soft tissues as well as in eggs of N. granulata is of great importance considering that this is a key species within the Bah&#305;´a Blanca estuary; therefore, it plays a major role inthe transference of pollutants to greater trophic levels.","palabras_clave":"NEOHELICE GRANULATA|DECAPOD CRUSTACEAN|HEAVY METALS|SOFT TISSUE AND EGGS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88022,"idioma_id":4,"titulo":"Inhibitory effect of 10 natural phenolic compounds on Fusarium verticillioides.  A structure property activity relationship study","resumen":"Fusarium is a ubiquitous hyalohyphomycete fungus usually isolated from food, which is widespread in different environments (plant, grain, soil) and present at all latitudes. This genus has been widely studied due to its ability to infect, cause tissue destruction and produce mycotoxins on important crops such as corn, wheat and other small grains. Over recent years, much effort has been directed at the search for new antifungal materials from natural sources, and many antimicrobial compounds coming from plants have been identified. Although the essential oils and their components have been recommended as fumigants for preservation of food commodities, little is known about the molecular properties related to the antifungal activity. In the present study, we performed a QSAR study for the inhibition of&nbsp;Fusarium verticillioides&nbsp;growth by ten natural phenolic compounds, which could serve as a guide for the rational design of further inhibitors. The results of the experimental determinations demonstrated that in terms of the antifungal activity of natural phenolic compounds on&nbsp;F. verticillioides, the following order was found: carvacrol&nbsp;&gt;&nbsp;thymol&nbsp;&gt;&nbsp;isoeugenol&nbsp;&gt;&nbsp;eugenol&nbsp;&gt;&nbsp;vanillin&nbsp;&gt;&nbsp;creosol&nbsp;&gt;&nbsp;m-cresol&nbsp;&gt;&nbsp;o-cresol, p-cresol, and guaiacol. Mathematical models based on molecular properties, Lipophilicity, Molar refractivity and Saturated area were found to be the descriptors that best explained the antifungal activity of these compounds. These models could be used in future to predict the activity of new compounds and to guide the search for the synthesis of phenolic compounds with the capacity to alter&nbsp;F.&nbsp;verticillioides&nbsp;growth.","palabras_clave":"Fusarium verticilloides|Natural compounds|Structure property activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88023,"idioma_id":4,"titulo":"Fumonisins: Probable role as effectors in the complex interaction of susceptible and resistant maize hybrids and Fusarium verticillioides","resumen":"Fusarium verticillioides is best known for its worldwide occurrence on maize resulting in highly variable disease symptoms, ranging from asymptomatic to severe rotting and wilting and fumonisin production. The aim of this study was to investigate the influence of hybrid genotypes in the early stages of F. verticillioides infection, and the role of fumonisins as effectors in the outcome of this complex interaction. Disease symptoms, growth parameters, root morphology and fungal colonization were evaluated at 7, 14 and 21 days after planting in seedlings from maize seeds of resistant (RH) and susceptible (SH) hybrids inoculated with F. verticillioides or watered with solutions of fumonisins. F. verticillioides induced growth enhancement or retardation depending on the plant genetic background and the fungal colonization rate, while fumonisins caused severe reduction in biomass and fitness. Seedlings watered with high fumonisin concentrations, displayed lesions similar to those seen in F. verticillioides maize seedling disease, and also elicited inhibitory effects on root growth and morphology and on functional properties. In summary, these data strongly suggest a dual role for fumonisins in the F. verticillioides-maize interaction, acting as pathogenic factors at high concentrations, or triggering the plant detoxification mechanisms at low levels.","palabras_clave":"FUSARIUM VEERTICILLIOIDES|FUMONISINS|ZEA MAYS L|EFFECTORS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88024,"idioma_id":4,"titulo":"Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells","resumen":"Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) are mycotoxins widely found as cereal contaminants. Their immunotoxicities predispose to infectious diseases and may alter the tumor immunosurveillance of human and animals, but the mechanisms underlying have not been fully elucidated, and the induction of oxidative stress has been proposed as a probable mechanism. This work was aimed at evaluating in spleen mononuclear cells (SMC) from  Wistar rats the effects of the exposure, in vitro for up to 48 h, to 20 uM AFB1, 10 uM FB1 and AFB1- FB1 mixture (MIX), over cellular oxidative status, as well as at elucidating the contribution of different reactive oxygen species (ROS) to biomolecular oxidative damage, the biochemical pathways involved, and the probable interaction of both toxins to induce  oxidative stress. All the treatments increased total ROS and oxidation of biomolecules, with MIX having the greatest effects. However, only MIX increased superoxide anion radical. The main ROS involved in oxidation of proteins, lipids and DNA appear to be hydrogen peroxide and hydroxyl radical. The mitochondrial Complex I and CYP450 were involved in the ROS  generation induced by all treatments. The NADPH oxidase was ROS sources of exposure to FB1 and MIX. The arachidonic acid metabolism contributed to the ROS formation induced by AFB1 and MIX. These results demonstrate that an interaction between AFB1 and FB1 occur in the oxidative stress induction, and show the biochemical pathways involved in ROS generation in SMC. The oxidative stress could mediate the AFB1 and FB1 individual and combined immunotoxicities.","palabras_clave":"AFLATOXIN B1|FUMONISIN B1|ROS SOURCES|BIOMOLECULAR OXIDATIVE DAMAGE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88025,"idioma_id":4,"titulo":"Random mating and reproductive compatibility among Argentinean and southern Brazilian populations of Anastrepha fraterculus (Diptera: Tephritidae)","resumen":"As a prerequisite for area-wide application of the sterile insect technique in an area encompassing northern Argentina and southern Brazil, prezygotic and postzygotic reproductive compatibility among three geographically distant populations in the area was tested. In field cages, sexually mature adults of each population were found to be sexually compatible, mating duration was not affected by fly origin and there was no clear evidence of spatial partition of mating location. In the laboratory, homotypic and heterotypic crosses for all possible combinations displayed similar levels of fertility and yielded F1 adults without distortion of the sex ratio. Finally, F1 hybrid and parental adults produced equally viable F2 eggs. Put together, our resultsand those from earlier studies suggest that a large area, ranging from Buenos Aires to the surroundings of São Paulo, could be managed using a single A. fraterculus massreared strain. At the northern margin of this area, two A. fraterculus morphotypes appear to coexist in sympatry. We delineate future research to further delimit the distribution of the aff1 morphotype (Argentina-southern Brazil) and to gain insight into evolutionary patterns producing divergence and radiation of tropical fruit fly species.","palabras_clave":"ANASTREPHA FRATERCULUS|CRYPTIC SPECIES|REPRODUCTIVE COMPATIBILITY|STERILE INSECT TECHNIQUE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88026,"idioma_id":4,"titulo":"First record of Atlantic mud piddock, Barnea (Anchomasa) truncata (Bivalvia, Pholadidae) in Argentina","resumen":"The present work reports the finding of an exotic bivalve, Barnea (Anchomasa) truncata, in the intertidal zone of the Bahía Blanca Estuary Argentina (38º Lat S), more than 2000 km south from the edge of its native range in South America (21º Lat S, Brazil). Lines of evidence suggest that larval transport by shipping is the probable entry route of this species. The most apparent modification created by the introduction of this species is the generation of greater complexity and habitat heterogeneity in the mud tidal plain of the estuary; the consequent effects on the local biota should therefore be evaluated.","palabras_clave":"PHOLADIDAE|NON-INDIGENOUS BIVALVE|BAHIA BLANCA ESTUARY|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88027,"idioma_id":4,"titulo":"Changes in actin and E-cadherin expression induced by 5-aminolevulinic acid photodynamic therapy in normal and Ras-transfected human mammary cell lines","resumen":"Photodynamic therapy (PDT) is an anticancer treatment based on light-induced destruction of photosensitised malignant cells. It has been reported that PDT strongly affects cell?cell and cell-substrate adhesion through the reorganization of some cytoskeletal and adhesion proteins.    The aim of the present work was to study the changes induced by PDT employing aminolevulinic acid (ALA), on the cytoskeleton actin network and E-cadherin expression. We employed the normal mammary HB4a cell line and its tumor counterpart transfected with the oncogene H-Ras, which has been shown to be resistant to PDT.    Ras insertion induces per se disorganization of both F-actin and E-cadherin distribution. ALA-PDT induces on HB4a cells a dramatic disorganization of actin stress fibers, resembling normal Ras-transfected cells. After 48 h some features of disorganization remain present. In HB4a-Ras cells, F-actin exhibits signals of photodamage, but distribution is recovered 24 h after treatment. On the other hand, PDT did not impact on E-cadherin distribution, other than a transient disorganization, which was recovered at 24 h. Moreover, E-cadherin disorganization did not favoured cell?cell detachment after PDT of HB4a-Ras cells.    Actin but not E-cadherin constitutes in this model an important target of PDT. The fact that some features of microfilament disorganization remain present in HB4a surviving cells but not in Ras-transfected cells, suggests that cytoskeletal structures such as F-actin may be involved in the mechanisms of resistance to PDT.","palabras_clave":"PHOTOYNAMIC THERAPY|CANCER|ACTIN|RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88028,"idioma_id":4,"titulo":"Antigen vehiculization particles based on the Z protein of Junin Virus","resumen":"Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins. In these VLPs, Z protein is associated to the plasma membrane inner surface by its myristoyl residue. Budding induction and vesicle formation properties can be exploited to generate enveloped VLPs platform. These structures can be designed to carry specific antigen in the inner side or on the surface of VLPs.Vaccines based on VLPs are a highly effective type of subunit vaccines that mimic the overall structure of virus particles in absence of viral nucleic acid, being noninfectious.In this work we assayed the capacity of Junin Z protein to produce VLPs carrying the green fluorescent protein (eGFP), as a model antigen.","palabras_clave":"Virus_like_particles|Antigen_delivery|Arenavirus|Z_protein"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88029,"idioma_id":4,"titulo":"Grazing rates of protists in wetlands under contrasting light conditions due to floating plants","resumen":"ABSTRACT: We examined the effect of light attenuation, due to floating plants, on the community structure of the main phagotrophic protists and their grazing rates in a wetland in the Lower Paraná Basin. Ingestion experiments (winter and summer) were conducted at 2 sites in the same shallow lake that had contrasting light scenarios: open waters (light) and under profuse macrophyte coverage (dark: light attenuation ~97%). We compared the rates at which protists ingested 3 types of tracer prey: fluorescently labelled heterotrophic bacteria (FLB), picocyanobacteria (FLC) and picoeukaryotic algae (FLA). Light influenced both the structure of the microbial communities and the protistan grazing rates. Heterotrophic flagellates (HF) were more abundant under the macrophytes, whereas mixotrophic algae (cryptophytes) and autotrophic and heterotrophic picoplankton populations attained higher abundances in open waters. Specific grazing rates (SGRs) of mixotrophs on heterotrophic bacteria (HB) were higher in the light (7.9 to 15.5 prey cells grazer&#8722;1 h&#8722;1), than in darkness (0.1 to 5.1 prey cells grazer&#8722;1 h&#8722;1); the same trend was observed on picocyanobacteria (Pcy) (1.1 and 0.2 prey cells grazer&#8722;1 h&#8722;1, light and dark). SGRs of HF were 1.0 to 7.3 cells grazer&#8722;1 h&#8722;1 (on HB) and 0.01 to 1.8 prey cells grazer&#8722;1 h&#8722;1 (on Pcy), with highest values in summer and no pattern in relation to light. SGRs of ciliates were higher in summer and in darkness. Clearance rates (CR) on Pcy were higher than on HB, for both HF and mixotrophic algae. In winter, cryptophytes contributed up to 93% of the microbial grazing in the light, whereas HF were more important in darkness; in summer, bacterivory was dominated by heterotrophs in both light scenarios. Our experimental results highlight the importance of light conditions in structuring bacterial grazing by protists.","palabras_clave":"PHAGOTROPHY|PROTISTS|MIXOTROPHIC ALGAE|GRAZING RATES|WETLAND|LIGHT ATTENUATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88030,"idioma_id":4,"titulo":"Direct and indirect effects of the glyphosate formulation Glifosato  Atanor ® on freshwater microbial communities","resumen":"Glyphosate-based formulations are among the most widely used herbicides in the world. The effect of the formulation Glifosato Atanor on freshwater microbial communities (phytoplankton, bacterioplankton, periphyton and zooplankton) was assessed through a manipulative experiment using six small outdoor microcosms of small volume. Three of the microcosms were added with 3.5 mg l-1 of glyphosate whereas the other three were left as controls without the herbicide. The treated microcosms showed a significant increase in total phosphorus, not fully explained by the glyphosate present in the Glifosato Atanor ®. Therefore, part of the phosphorus should have come from the surfactants of the formulation. The results showed significant direct and indirect effects of Glifosato Atanor on the microbial communities. A single application of the herbicide caused a fast increase both in the abundance of bacterioplankton and planktonic picocyanobacteria and in chlorophyll a concentration in the water column. Although metabolic alterations related to oxidative stress were induced in the periphyton community, the herbicide favored its development, with a large contribution of filamentous algae typical of nutrient-rich systems, with shallow and calm waters. An indirect effect of the herbicide on the zooplankton was observed due to the increase in the abundance of the rotifer Lecane spp. as a consequence of the improved food availability given by picocyanobacteria and bacteria. The formulation affected directly a fraction of copepods as a target. It was concluded that the Glifosato Atanor® accelerates the deterioration of the water quality, especially when considering small-volume water systems. © Springer Science+Business Media, LLC 2012.","palabras_clave":"Glyphosate formulation|Microcosms|Microbial communities|Water quality"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88031,"idioma_id":5,"titulo":"Morfodinámica de un campo de dunas submarinas en una entrada de marea: San Blas, Argentina","resumen":"Se estudió la morfología de un campo de dunas submarinas desarrollado en una entrada de marea que conecta la plataforma continental argentina con bahía Anegada (sur de la provincia de Buenos Aires). Se infiere la circulación sedimentaria a partir del desplazamiento diferencial de las geoformas medido en relevamientos consecutivos. Como parte de la metodología se utilizó un ecosonda y un sistema batimétrico por medición de fase (SBMF) denominado GeoSwath que permitieron obtener la morfología submarina en detalle. Se observaron dunas grandes sobre el límite sur del campo de dunas con altura entre 4,5 y 5,0 m y espaciamiento entre 100 y 120 m, a profundidades de 24 m, que se desplazan hacia el exterior del canal a una rapidez entre 18 y 75 m año-1. Hacia el límite norte del campo, a 21 m de profundidad las dunas eran de menor magnitud, entre 2,0 y 2,5 m de altura y espaciamiento entre 40 y 80 m, y se desplazaron a una rapidez entre 18 y 36 m año-1 hacia el interior de bahía Anegada. Se obtuvo la distribución del flujo de agua en toda la columna, en un perfil perpendicular al canal relevado, mediante ADCP. Los valores máximos de rapidez de corriente fueron durante la marea creciente, alcanzando 2,0 m s-1. Los resultados obtenidos permiten definir un modelo circulatorio de transporte de sedimentos arenosos, con la formación de un delta de marea de flujo en la cabecera de la entrada de marea y un delta de reflujo en el límite del dominio oceánico, unidos por una garganta de marea profunda, exenta de sedimentos inconsolidados.","palabras_clave":"CAMPO DE DUNAS|VELOCIDAD DE MIGRACIÓN|TRANSPORTE DE SEDIMENTOS|GEOSWATH|ADCP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88032,"idioma_id":4,"titulo":"Non-inclusion complexes between riboflavin and cyclodextrins","resumen":"Objectives To investigate the molecular interaction between   b-cyclodextrin (bCD)  or hydroxypropyl-b-cyclodextrin (HPbCD) and   riboflavin (RF), and to test the  anticancer potential of these   formulations.  Methods The physicochemical characterization of the   association between RF and  CDs was performed by UV-vis absorption,   fluorescence, differential scanning calorimetry  and NMR techniques.   Molecular dynamics simulation was used to shed  light on the mechanism   of interaction of RF and CDs. Additionally, in-vitro cell  culture tests   were performed to evaluate the cytotoxicity of the RF?CD complexes    against prostate cancer cells.  Key findings Neither bCD nor HPbCD led   to substantial changes in the physicochemical  properties of RF (with   the exception of solubility).Additionally, rotating  frame Overhauser   effect spectroscopy experiments detected no spatial correlations    between hydrogens from the internal cavity of CDs and RF, while   molecular  dynamics simulations revealed ?out-of-ring? RF?CD   interactions.Notwithstanding,  both RF?bCD and RF?HPbCD complexes were   cytotoxic to PC3 prostate cancer  cells.  Conclusions The interaction   between RF and either bCD or HPbCD, at low concentrations,  seems to be   made through hydrogen bonding between the flavonoid  and the external   rim of both CDs. Regardless of the mechanism of complexation,  our   findings indicate that RF?CD complexes significantly increase RF   solubility and  potentiate its antitumour effect.","palabras_clave":"CYCLODEXTRIN|NMR|NON-INCLUTION COMPLEX|RIBOFLAVIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88033,"idioma_id":4,"titulo":"Enthalpy change in the magnetocaloric effect","resumen":"We report a study of the magnetocaloric effect in magnetic systems by   extracting the temperature change from the enthalpy difference between   the high and the low magnetic field phases. To evaluate this alternative   approach, we compare the results extracted from the proposed model with   direct measurements of the adiabatic temperature change. Results   obtained in the manganite compound Pr0.5Sr0.41Ca0.09MnO3   are used to show that this method is valid and useful to evaluate the   magnetocaloric effect in different solid state systems, and to follow   the heat dynamic of the system while a magnetic first order phase   transition takes place","palabras_clave":"magnetocaloric|magnetic refrigertation|phase transitions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88034,"idioma_id":4,"titulo":"Land-use planning based on ecosystem service assessment: A case study in the Southeast Pampas of Argentina","resumen":"A methodological protocol of strategic environmental assessment was developed to incorporate the valuation of ecosystem services in land use plans. The protocol was applied in rural land planning at Balcarce, a  department representative of the Southeast Pampas Region (Argentina). The ecosystem services approach was used as valuation criteria of the 14 principal ecosystems classified in the studied area, where agricultural  is the predominant economic activity. The provision of seven principal ecosystem services related to regulation functions or food production was estimated for each ecosystem using a set of indicators integrating  climatic, vegetation and terrain variables. The assessment of land use changes showed a significant increase in agriculture in the past 20 years, which affected mainly natural grasslands. The environmental impact of this replacement varied according to the ecosystem and the area. Hills and riparian zones were identified as key areas for grassland conservation in order to provide regulation ecosystem services in  agricultural landscapes. On the basis of this analysis, a preliminary zoning was proposed, aimed to retain critical support and regulation ecosystem services without significantly sacrificing food production for  humans. Strategic environmental assessment based on ecosystem services appears as a powerful tool to prevent negative environmental costs of land use plans which can remain unnoticed under traditional  environmental impact assessment techniques.","palabras_clave":"Strategic environmental assessment|Ecosystem services|Land use planning"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88035,"idioma_id":4,"titulo":"Gold catalysis on immobilized substrates: a heteroannulation approach to the solid-supported synthesis of indoles","resumen":"  A gold-catalyzed cyclization of immobilized 2-alkynylanilines was developed as the key step in the synthetic sequence for the preparation of 2-substituted indoles. These results demonstrate the potential of the unexplored combination of gold catalysis and solid-phase organic synthesis.  ","palabras_clave":"Gold catalysis|solid-phase synthesis|heterocycles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88036,"idioma_id":4,"titulo":"Penicillium chrysogenum: Phenol Degradation Abilities and Kinetic Model","resumen":"Phenol is a typical contaminant of the environment generated by many industries. Several fungi had been reported to degrade phenol as the only source of carbon and energy, but many of them are not useful to apply in soil bioremediation process. In this work, we study the dynamics of phenol degradation by a Penicillium chrysogenum, isolated from soil. Degradation of phenol was studied at room temperature and resting mycelium conditions. High specific degradation rates were obtained. Inhibition was observed on the specific growth rate (30 mg l1) and the degradation rate (200 mg l&#8722;1). Experimental results were fitted to several models during exponential phase, with the Andrews-Haldane model given the best fit. Dynamic mass balance equations for biomass and phenol during the exponential and stationary growth phases were solved and compared very satisfactorily to experimental outcomes. P. chrysogenum degrades phenol completely during the exponential and stationary growth phases. The results obtained are relevant for its practical applications in soil decontamination processes. Model predictions were satisfactory. This is the first work which describes a kinetic model for phenol biodegradation using a filamentous fungus considering both, exponential and stationary phases, and the first one in which a Penicillium isolate is used.","palabras_clave":"Penicillium chrysogenum|phenol degradation|kinetic modelling|penicillium degradation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88037,"idioma_id":4,"titulo":"Improving the MVA Vaccine Potential by Deleting the Viral Gene Coding for the IL-18 Binding Protein","resumen":"Background: Modified Vaccinia Ankara (MVA) is an attenuated strain of Vaccinia virus (VACV) currently employed in many  clinical trials against HIV\/AIDS and other diseases. MVA still retains genes involved in host immune response evasion,  enabling its optimization by removing some of them. The aim of this study was to evaluate cellular immune responses (CIR)  induced by an IL-18 binding protein gene (C12L) deleted vector (MVADC12L).  Methodology\/Principal Findings: BALB\/c and C57BL\/6 mice were immunized with different doses of MVADC12L or MVA  wild type (MVAwt), then CIR to VACV epitopes in immunogenic proteins were evaluated in spleen and draining lymph  nodes at acute and memory phases (7 and 40 days post-immunization respectively). Compared with parental MVAwt,  MVADC12L immunization induced a significant increase of two to three-fold in CD8+ and CD4+ T-cell responses to different  VACV epitopes, with increased percentage of anti-VACV cytotoxic CD8+ T-cells (CD107a\/b+) during the acute phase of the  response. Importantly, the immunogenicity enhancement was also observed after MVADC12L inoculation with different  viral doses and by distinct routes (systemic and mucosal). Potentiation of MVA?s CIR was also observed during the memory  phase, in correlation with a higher protection against an intranasal challenge with VACV WR. Of note, we could also show a  significant increase in the CIR against HIV antigens such as Env, Gag, Pol and Nef from different subtypes expressed from  two recombinants of MVADC12L during heterologous DNA prime\/MVA boost vaccination regimens.  Conclusions\/Significance: This study demonstrates the relevance of IL-18 bp contribution in the immune response evasion  during MVA infection. Our findings clearly show that the deletion of the viral IL-18 bp gene is an effective approach to  increase MVA vaccine efficacy, as immunogenicity improvements were observed against vector antigens and more  importantly to HIV antigens.","palabras_clave":"Vaccines|MVA|immune evasion|IL-18"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88038,"idioma_id":4,"titulo":"A New Phymaturus (Iguania: Liolaemidae) from the Southern Extreme of the Argentine Puna","resumen":"We describe a new species of Phymaturus from the Sierra La Invernada of San Juan Province, Argentina. The new species shares the apomorphies of the P. palluma group including a fragmented subocular, square nonimbricate superciliaries, rugose and strongly mucronate dorsal caudals, and a midvertebral band of enlarged scales. Within the P. palluma group, the new species can be assigned to the Puna clade, with which it shares a dorsal pattern of small, dispersed brown spots and lack of black reticulations. The new species differs from other members of the Puna clade in several aspects of squamation and body pattern and color. Most notably, the new Phymaturus has a conspicuous yellow scapular spot, lacks a vertebral stripe, and has incomplete dark pigmentation over the dorsal neck. The new species is known only from the region of the type locality, the southernmost (and geographically isolated) extent of the Puna phytogeographic province, where it occurs at high elevations (>3100 m). We provide information on aspects of the natural history, diet, thermal biology, and apparent parental care exhibited by females of the new species.","palabras_clave":"Nueva especie|Phymaturus sp|Liolaemidae|Puna"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88039,"idioma_id":4,"titulo":"The tadpole of Pleurodema nebulosum Burmeister (Anura: Leiuperidae)","resumen":"Se re-describe la larva de P. nebulosum, la cual fue descrita de forma sencilla por Cei (1980) y otros autores. El objetivo del presente trabajo fue brindar información detallada a cerca de la morfología larval.","palabras_clave":"Pleurodema nebulosum|Larvas|Re-descripción"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88040,"idioma_id":4,"titulo":"A Luminescent Steroid-based Organogel: ON-OFF Photoswitching by Dopant Interplay and Templated Synthesis of Fluorescent Nanoparticles","resumen":"The modulation of the fluorescence emission of a perylene dye between ON and OFF states was achieved with high efficiency by&nbsp;means of a diarylethene photochromic compound in an organogel medium. Fluorescent gels were prepared from a steroidal low molecular weight organogelator doped with the perylene fluorophore. The compatibility of the photochromic compound in this medium and the non-destructive readout capability were demonstrated. The dye doped organogel was further used as a template and an innovative method was employed to grow fluorescent silica spherical nanoparticles with physically and chemically admixed perylene dye.","palabras_clave":"Fluorescence|Perylene|Organogel|Nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88041,"idioma_id":4,"titulo":"Evaluation of indigenous bacterial strains for biocontrol of the frogeye leaf spot of soya bean caused by Cercospora sojina","resumen":"Abstract  AIMS:  Assessment of biological control of Cercospora sojina, causal agent of frogeye leaf spot (FLS) of soya bean, using three indigenous bacterial strains, BNM297 (Pseudomonas fluorescens), BNM340 and BNM122 (Bacillus amyloliquefaciens).  METHODS AND RESULTS:  From cultures of each bacterial strain, cell suspensions and cell-free supernatants were obtained and assayed to determine their antifungal activity against C. sojina. Both mycelial growth and spore germination in vitro were more strongly inhibited by bacterial cell suspensions than by cell-free supernatants. The Bacillus strains BNM122 and BNM340 inhibited the fungal growth to a similar degree (I &#8776; 52-53%), while cells from P. fluorescens BNM297 caused a lesser reduction (I &#8776; 32-34%) in the fungus colony diameter. The foliar application of the two Bacillus strains on soya bean seedlings, under greenhouse conditions, significantly reduced the disease severity with respect to control soya bean seedlings and those sprayed with BNM297. This last bacterial strain was not effective in controlling FLS in vivo.  CONCLUSIONS:  Our data demonstrate that the application of antagonistic bacteria may be a promising and environmentally friendly alternative to control the FLS of soya bean. Significance and Impact of the Study:&#8194; To our knowledge, this is the first report of biological control of C. sojina by using native Bacillus strains","palabras_clave":"BIOLOGICAL CONTROL |CERCOSPORA SOJINA|FROGEYE LEAF SPOT |PSEUDOMONAS FLUORESCENS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88042,"idioma_id":4,"titulo":"Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells","resumen":"Serum prolactin (PRL) variations play a crucial role in the photoperiodic-induced testicular regression-recrudescence transition in hamsters. We have previously shown that cyclooxygenase 2 (COX2), a key enzyme in the biosynthesis of prostaglandins (PGs), is expressed mostly in Leydig cells of reproductively active hamsters with considerable circulating and pituitary levels of PRL. In this study, we describe a stimulatory effect of PRL on COX2\/PGs in hamster Leydig cells, which is mediated by IL-1&#946; and prevented by P38-MAPK and JAK2 inhibitors. Furthermore, by preparative isoelectric focusing (IEF), we isolated PRL charge analogues from pituitaries of active [isoelectric points (pI): 5.16, 4.61, and 4.34] and regressed (pI: 5.44) hamsters. More acidic PRL charge analogues strongly induced COX2 expression, while less acidic ones had no effect. Our studies suggest that PRL induces COX2\/PGs in hamster Leydig cells through IL-1&#946; and activation of P38-MAPK and JAK2. PRL microheterogeneity detected in active\/inactive hamsters may be responsible for the photoperiodic variations of COX2 expression in Leydig cells.","palabras_clave":"Prolactin  |Cyclooxygenase 2| Prostaglandins|Leydig cells|Hamsters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88043,"idioma_id":4,"titulo":"Development, Characterization, and In Vitro Evaluation of Tamoxifen Microemulsions","resumen":"Microemulsions (MEs) were designed by an innovative rational development, characterized, and used to load up to 20mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of administration. Some of their properties, such as nanometric mean size and long stability shelf life, make them interesting drug delivery systems. The results obtained after the in vitro inhibition of estradiol-induced proliferation in MCF-7 breast cancer cells demonstrated a significant effect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20mM of TMX. Besides, two compositions which loaded 10mMof drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for estrogen receptor (ER) positive tumors, but also for ER negative.ffect in cell growth. A decreasing of at least 90% in viable cells was shown after the incubation with MEs containing 20mM of TMX. Besides, two compositions which loaded 10mMof drug showed a cytotoxic effect higher than 70%. These results encourage the evaluation of alternative protocols for this drug administration, not only for estrogen receptor (ER) positive tumors, but also for ER negative.","palabras_clave":"tamoxifen|microemulsions|breast cancer"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88044,"idioma_id":4,"titulo":"Formulation Strategies, Characterization, and In Vitro Evaluation of Lecithin-Based Nanoparticles for siRNA Delivery","resumen":"The aim of the present work was to take advantage of lecithin?s biocompatibility along with its physicochemical properties for thepreparation of lecithin-based nanocarriers for small interfering RNA (siRNA) delivery. Water lecithin dispersions were preparedin different conditions, loaded with siRNA at different N\/P ratios, and evaluated for loading capacity. The most appropriate ones were then assayed for cytotoxicity and characterized in terms of particle size distribution, zeta potential, and morphology. Resultsdemonstrated that formulations prepared at pH 5.0 and 7.0 were able to load siRNA at broad N\/P ratios, and cellular uptake assaysshowed an efficient delivery of oligos in MCF-7 human breast cancer cells; fluorescent-labeled dsRNA mainly located next to its target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.were then assayed for cytotoxicity and characterized in terms of particle size distribution, zeta potential, and morphology. Resultsdemonstrated that formulations prepared at pH 5.0 and 7.0 were able to load siRNA at broad N\/P ratios, and cellular uptake assaysshowed an efficient delivery of oligos in MCF-7 human breast cancer cells; fluorescent-labeled dsRNA mainly located next to its target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.fferent conditions, loaded with siRNA at different N\/P ratios, and evaluated for loading capacity. The most appropriate ones were then assayed for cytotoxicity and characterized in terms of particle size distribution, zeta potential, and morphology. Resultsdemonstrated that formulations prepared at pH 5.0 and 7.0 were able to load siRNA at broad N\/P ratios, and cellular uptake assaysshowed an efficient delivery of oligos in MCF-7 human breast cancer cells; fluorescent-labeled dsRNA mainly located next to its target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.fficient delivery of oligos in MCF-7 human breast cancer cells; fluorescent-labeled dsRNA mainly located next to its target, near the nucleus of the cells. No signs of toxicity were observed for broad compositions of lecithin. The physicochemicalcharacterization of the siRNA-loaded dispersions exhibited particles of nanometric sizes and pH-dependant shapes, which makethem suitable for ex vivo and in vivo further evaluation.ex vivo and in vivo further evaluation.","palabras_clave":"SIRNA|DELIVERY|FORMULATION|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88045,"idioma_id":4,"titulo":"Size fractionated phytoplankton production in two humic shallow lakes with contrasting coverage of free floating plants","resumen":"We conducted a 1-year survey in twohumic shallow lakes from the floodplain of the LowerParaná River, Laguna Grande Lake (LGL) and arelictual oxbow lake (ROL). We aimed to test twohypotheses: (1) the efficiency in light use of picoplankton(0.2-3 um) is greater as light restrictionincreases and (2) the contribution of picoplankton tothe total productivity is higher when the total photosyntheticbiomass is lower.We performed P-E curvesfor picoplankton and nano- and microplankton(&gt;3 um) using the 14C assimilation technique. Thelight environments of the water bodies differed mainlyowing to the development of free floating plants on thesurface of the ROL and the dominance of phytoplanktonin LGL. Primary productivity patterns in LGLwere seasonality driven whilst in the ROL they wererelated to the coverage of floating macrophytes, whichpromoted light limitation and a lower productivity. InLGL, nano- and microplankton were in general moreproductive and the relative contribution of picoplanktonto the total phytoplankton production decreasedwith the increase in total photosynthetic biomass.Hence, our study extends previously observed patternsto subtropical shallow lakes, where seasonality andfree floating plants may influence the dynamics ofphytoplankton production.","palabras_clave":"PICO-, NANO- AND MICROPHYTOPLANKTON|PRODUCTIVITY|HUMIC SHALLOW LAKES|SUBTROPICAL WETLAND|SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88046,"idioma_id":4,"titulo":"Further insights on the physico-chemical aspects of PdIn-Hmordenite catalysts for the NOx-SCR with CH4","resumen":"The addition of Pd  improves the catalytic performance of InHMordenite for the SCR of NO with  methane, but this effect depends on the In\/Al ratio. We studied two  PdInMordenite samples, one with In\/Al = 1\/3 (PdInHM(1\/3)) and the other with  In\/Al = 1\/6 (PdInHM(1\/6)). While in the former the presence of Pd in the  InHM(1\/3) catalyst increased the activity, in the sample with lower In content  this effect is not observed. In order to explain these observations, the  catalysts were characterized with several techniques. TPR results showed that  the presence of palladium shifted the reduction peak of the solid PdInHM(1\/3)  towards higher temperatures, while on the solid PdInHM(1\/6) the shift was negligible.  This effect could be ascribed to a higher Pd-In interaction in the PdInHM(1\/3)  catalyst. FTIR of CO adsorbed showed the presence of Pd2+, Pd+  and Pd0 adsorption sites in the calcined PdInHM(1\/3). However, in  the case of the PdInHM(1\/6) there was no evidence of Pd2+ species. The  TEM images of used PdInHM(1\/3) catalysts suggested the mobilization of indium  to inner positions into the matrix, thus increasing the interactions with Pd. In  the fresh PdInHM(1\/6) the indium particles could not be detected but after  reaction some agglomeration of particles could be observed, which is in  agreement with CO-FTIR and XPS results. In brief, the results indicate that in the  PdInHM(1\/3) catalyst Pd and In closely interact giving place to a promotional  effect of Pd, which prevents the agglomeration of In species.","palabras_clave":"In,Pd,H-mordenite|CO-FTIR|SCR-NOx|In-Pd interaction|TEM-EDX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88047,"idioma_id":4,"titulo":"Genome Sequence of Rhizobium grahamii CCGE502, a Broad-Host-Range Symbiont with Low Nodulation Competitiveness in Phaseolus vulgaris","resumen":"Here we present the genome sequence of Rhizobium grahamii CCGE502. R. grahamii groups with other newly described broad-host-range species, which are not very efficient Phaseolus vulgaris symbionts, with a wide geographic distribution and which constitutes a novel Rhizobium clade.","palabras_clave":"rhizobia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88048,"idioma_id":4,"titulo":"Ground-state energy and entropy of the two-dimensional Edwards-Anderson spin-glass model with different bond distributions","resumen":"We study the two-dimensional Edwards\u2013Anderson spin-glass model using a parallel temperingMonte Carlo algorithm. The ground-state energy and entropy are calculated fordifferent bond distributions. In particular, the entropy is obtained by using a thermodynamicintegration technique and an appropriate reference state, which is determined withthe method of high-temperature expansion. This strategy provides accurate values of thisquantity for finite-size lattices. By extrapolating to the thermodynamic limit, the groundstateenergy and entropy of the different versions of the spin-glass model are determined.","palabras_clave":"SPIN-GLASSES|SIMULATIONS|ENTROPY|GROUND-STATE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88049,"idioma_id":4,"titulo":"Dynamical heterogeneities as fingerprints of a backbone structure in Potts models","resumen":"We investigate slow nonequilibrium dynamical processes in a two-dimensional q-state Potts model with both ferromagnetic and +\/-J couplings. Dynamical properties are characterized by means of the mean-flipping time distribution. This quantity is known for clearly unveiling dynamical heterogeneities. Using a two-times protocolwe characterize the different time scales observed and relate them to growth processes occurring in the system. In particular we target the possible relation between the different time scales and the spatial heterogeneities originated in the ground-state topology, which are associated to the presence of a backbone structure. We performnumerical simulations using an approach based on graphis processing units (GPUs) which permits us to reach large system sizes. We present evidence supporting both the idea of a growing process in the preasymptotic regime of the glassy phases and the existence of a backbone structure behind this process.","palabras_clave":"SPIN-GLASSES|SIMULATION|HETEROGENEITIES|BACKBONE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88050,"idioma_id":4,"titulo":"Genetic and functional characterization of a yet-unclassified rhizobial Dtr (DNA-transfer-and-replication) region from a ubiquitous plasmid conjugal system present in Sinorhizobium meliloti, in Sinorhizobium medicae, and in other nonrhizobial Gram-negativ","resumen":"Rhizobia are Gram-negative bacteria that live in soils and associate with leguminous plants to establish nitrogen-fixing symbioses. The ability of these bacteria to undergo horizontal gene transfer (HGT) is thought to be one of the main features to explain both the origin of their symbiotic life-style and the plasticity and dynamics of their genomes. In our laboratory we have previously characterized at the species level the non-pSym plasmid mobilome in Sinorhizobium meliloti, the symbiont of Medicago spp., and have found a high incidence of conjugal activity in many plasmids (Pistorio et al., 2008). In this work we characterized the Dtr (DNA-transfer-and-replication) region of one of those plasmids, pSmeLPU88b. This mobilization region was found to represent a previously unclassified Dtr type in rhizobia (hereafter type-IV), highly ubiquitous in S. meliloti and found in other genera of Gram-negative bacteria as well; including Agrobacterium, Ochrobactrum, and Chelativorans. The oriT of the type-IV Dtr described here could be located by function within a DNA fragment of 278 bp, between the divergent genes parA and mobC. The phylogenetic analysis of the cognate relaxase MobZ indicated that this protein groups close to the previously defined MOB(P3) and MOB(P4) type of enzymes, but is located in a separate and novel cluster that we have designated MOB(P0). Noteworthy, MOB(P0) and MOB(P4) relaxases were frequently associated with plasmids present in rhizospheric soil bacteria. A comparison of the nod-gene locations with the phylogenetic topology of the rhizobial relaxases revealed that the symbiotic genes are found on diverse plasmids bearing any of the four Dtr types, thus indicating that pSym plasmids are not specifically associated with any particular mobilization system. Finally, we demonstrated that the type-IV Dtr promoted the mobilization of plasmids from S. meliloti to Sinorhizobium medicae as well as from these rhizobia to other bacteria by means of their own helper functions. The results present an as-yet-unclassified and seemingly ubiquitous conjugal system that provides a mechanistic support for the HGT between sympatric rhizobia of Medicago roots, and between other soil and rhizospheric bacteria.","palabras_clave":"Relaxase|Cryptic plasmid|Conjugation machine|Rhizobia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88051,"idioma_id":4,"titulo":"Synthesis, structure and magnetic properties of La 3Co 2SbO 9: A double perovskite with competing antiferromagnetic and ferromagnetic interactions","resumen":"The synthesis, structural characterization, and magnetic properties of La3Co2SbO9 double perovskite are reported. The crystal structure has been refined by X-ray and neutron powder diffraction data in the monoclinic space group P21\/n. Co2+ and Sb5+ have the maximum order allowed for the La3Co2SbO9 stoichiometry. Rietveld refinements of powder neutron diffraction data show that at room temperature the cell parameters are a=5.6274(2) A, b=5.6842(2) A, c=7.9748(2) A and b=89.999(3)1. Magnetization measurements indicate the presence of ferromagnetic correlations with TC=55 K attributed to the exchange interactions for non-linear Co2+?O?Sb5+?O?Co2+ paths. The effective magnetic moment obtained experimentally is mexp=4.38 mB (per mol Co2+), between the theoretical one for spin only (3.87 mB) and spin-orbit value (6.63 mB), indicating partially unquenched contribution. The low magnetization value at high magnetic field and low temperature (1 mB\/f.u., 5 T and 5 K) and the difference between ZFC and FC magnetization curves (at 5 kOe) indicate that the ferromagnetism do not reach a long range order and that the material has an important magnetic frustration.","palabras_clave":"Magnetic frustrations|Magnetization measurements| Powder neutron diffraction|Double perovskites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88052,"idioma_id":4,"titulo":"Synthesis, structural characterization and Mössbauer study of LnV 0.5Fe 0.5O 3 perovskites (Ln = Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho and Er)","resumen":"Perovskites LnV0.5Fe0.5O3 (Ln = Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho and Er) were synthesized by rapid solidification from arc-melted samples and characterized by the study of their crystal structure and hyperfine properties. These metastable solid solutions crystallized in the Pbnm symmetry, with the iron and vanadium cations randomly distributed in the transition metal octahedral sites. Depending on the lanthanide present at the A site of the perovskite, iron is present with two valences (i.e., Fe3+ and Fe2+). The volume of the unit cell for these perovskites increases linearly with the lanthanide ionic radius, as the perovskite approaches its ideal structure. At room temperature, the quadrupolar splitting of the trivalent paramagnetic Mössbauer component works as an indirect measurement for the Goldshmidt tolerance factor. Close to or below 100 K, these perovskites undergo a crystallographic phase transformation, probably due to orbital ordering of the V3+ cations, originating two different magnetic iron sites. ","palabras_clave":"INORGANIC COMPOUNDS|OXIDES|MÖSSBAUER SPECTROSCOPY|X-RAY DIFFRACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88053,"idioma_id":4,"titulo":"The peptidases of Trypanosoma cruzi:  Digestive enzymes, virulence factors, and mediators of autophagy and programmed cell death.","resumen":"Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among these enzymes is cruzipain, a cysteine proteinase expressed as a mixture of isoforms, some of them membrane-bound. The enzyme is an immunodominant antigen in human chronic Chagas disease and seems to be important in the host\/parasite relationship. Inhibitors of cruzipain kill the parasite and cure infected mice, thus validating the enzyme as a very promising target for the development of new drugs against the disease. In addition, a 30 kDa cathepsin B-like enzyme, two metacaspases and two autophagins have been described. Serine peptidases described in the parasite include oligopeptidase B, a member of the prolyl oligopeptidase family involved in Ca2+-signaling during mammalian cell invasion; a prolyl endopeptidase (Tc80), against which inhibitors are being developed, and a lysosomal serine carboxypeptidase. Metallopeptidases homologous to the gp63 of Leishmania spp. are present, as well as two metallocarboxypeptidases belonging to the M32 family, previously found only in prokaryotes. The proteasome has properties similar to those of other eukaryotes, and its inhibition by lactacystin blocks some differentiation steps in the life cycle of the parasite. ","palabras_clave":"Trypanosoma cruzi|Peptidasas|Cruzipaína|Autofagia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88054,"idioma_id":4,"titulo":"Enzymatic maceration of albedo layer from sour orange (Citrus aurantium L.) with protopectinase-se and measurement of antioxidant activity of the obtained products","resumen":"    Protopectinase-SE was used to macerate  the albedo layer from sour orange (Citrus  aurantium). The effect of agitation on the process was evaluated and then,  antioxidant activity of the resulting preparation was determined by mean of the  methodologies DPPH, ABTS, and ferric reducing antioxidant power. The following  parameters were assayed:  the levels of  total phenols, reducing sugars, vitamin C, total flavonones, naringin, and  galacturonic acid as well as the preparation´s total acidity. It was found that  the use of either a reciprocal or orbital system of agitation, the latter  feature achieved with flasks having internal deflectors, yielded similar  maceration levels (33 g  \/ 100g). Moreover, the antioxidant activity, as well as the concentrations of  vitamin C and total flavonones  was the  highest with the greatest degree of tissue maceration. These results confirm  the effectiveness of the method of maceration for obtaining a form of cellular  disruption that result in a maximum conservation of the nutritional  characteristics of the processed tissue.","palabras_clave":"Protopectinase-SE |Sour orange (Citrus aurantium)|Antioxidant activity  |Agitation systems|Vitamin C |Conservation of nutrition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88055,"idioma_id":4,"titulo":"Biodegradation of a keratin waste and the concomitant production of detergent stable serine proteases from Paecilomyces lilacinus","resumen":"Paecilomyces lilacinus (LPS 876) efficiently degraded keratin in chicken featherduring submerged cultivation producing extracellular proteases. Characterization of crudeprotease activity was done including its compatibility in commercial detergents. OptimumpH and temperature were 10.0 and 60 °C, respectively. Protease activity was enhanced byCa2+ but was strongly inhibited by PMSF and by Hg2+ suggesting the presence of thioldependentserine proteases. The crude protease showed extreme stability toward non-ionic(Tween 20, Tween 85, and Triton X-100) and anionic (SDS) surfactants, and relativestability toward oxidizing agent (H2O2 and sodium perborate). In addition, it showedexcellent stability and compatibility with various solid and liquid commercial detergentsfrom 30 to 50 °C. The enzyme preparation retained more than 95% of its initial activity withsolid detergents (Ariel? and Drive?) and 97% of its original activity with a liquiddetergent (Ace?) after pre-incubation at 40 °C. The protective effect of polyols (propyleneglycol, PEG 4000, and glycerol) on the heat inactivation was also examined and thebest results were obtained with glycerol from 50 to 60 °C. Considering its promisingproperties, P. lilacinus enzymatic preparation may be considered as a candidate foruse in biotechnological processes (i.e., as detergent additive) and in the processing ofkeratinous wastes.","palabras_clave":"Paecilomyces lilacinus|Chicken feather| Keratinolytic activity| Detergent stable|Alkaline serine proteases"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88056,"idioma_id":4,"titulo":"Bioprocessing of 'Hair Waste' by Paecilomyces lilacinus as a Source of a Bleach-Stable, Alkaline, and Thermostable Keratinase with Potential Application as a Laundry Detergent Additive: Characterization and Wash Performance Analysis","resumen":"Paecilomyces lilacinus (Thom) Samson LPS&nbsp; 876, a locally isolated fungal strain, was grown on minimal mineral medium containing ?hair waste,? a residue from the hair-saving unhairing process, and produced a protease with keratinolytic activity. This enzyme was biochemically characterized. The optimum reaction conditions, determined with a response surface methodology, were 60°C and pH 6.0. It was remarkably stable in a wide range of pHs and temperatures. Addition of Ca2+, Mg2+, or sorbitol was found to be effective in increasing thermal stability of the protease. PMSF and Hg2+ inhibited the proteolytic activity indicating the presence of a thiol-dependent serine protease. It showed high stability toward surfactants, bleaching agents, and solvents. It was also compatible with commercial detergents (7&#8201;mg\/mL) such as Ariel, Skip, Drive, and Ace, retaining more than 70% of its proteolytic activity in all detergents after 1&#8201;h of incubation at 40°C. Wash performance analysis revealed that this protease could effectively remove blood stains. From these properties, this enzyme may be considered as a potential candidate for future use in biotechnological processes, as well as in the formulation of laundry detergents.","palabras_clave":"Serine proteases|Hair waste|Detergent stable|Thermostability|Keratinolytic activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88057,"idioma_id":4,"titulo":"Opposite actions of dopamine on aversive and appetitive memories in the crab","resumen":"The understanding of how the  reinforcement is represented in the central nervous system during memory  formation is a current issue in neurobiology. Several studies in insects  provide evidence of the instructive role of biogenic amines during learning and  memory process. In insects, it was widely accepted that dopamine (DA) mediates  aversive reinforcements. However, the idea of DA being exclusively involved in  aversive memory has been challenged in recent studies. Here we study the  involvement of DA during aversive and appetitive memories in the crab Chasmagnathus. We found that DA-receptor  antagonists impair aversive memory consolidation, in agreement with previous  reports in insects, while administration of DA facilitates memory formation after  a weak training protocol. By contrast, DA treatment during appetitive training  was found to impair formation of long-term appetitive memory. In addition, as a  first step to elucidate the neuroanatomical correlates of DA action on memory,  we mapped dopaminergic neurons in the central nervous system of the crab.  Results of the current study together with those obtained in a previous work  about the role of octopamine (OA) suggest that both amines (DA and OA) play a  dual action on memory processes. On the one hand, DA and OA mediate the aversive  and the appetitive signals respectively throughout training, while on the  other, they interfere with the formation of memory of the opposite sign (DA in  appetitive and OA in aversive). Our results support a new understanding about  the way appetitive and aversive stimuli are processed during memory formation  to ensure adaptive behavior.","palabras_clave":"dopamine|aversive memory|appetitive memory|unconditioned stimulus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88058,"idioma_id":5,"titulo":"Búsqueda de variaciones de las abundancias químicas con la edad en las estrellas CP de Hg-Mn","resumen":"The purpose of these project is to verify if some relation exist between chemical abundances of some critical elements and the age of the stars. We selected HgMn stars in different clusters and field stars with data in the Hip- parcos catalog to provide the correct position in the HR diagram. In these report we show some results obtained analizing the possible trends observed in the chemical abundance vs age relation for 4 sample stars: HD 129174, HD 186122, HD 78316 and HD 53244. The observations were done with the CASLEO EBASIM spectrograph between the years 2007 and 2010. ","palabras_clave":"Estrellas|Estrellas CP|abundancias"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88059,"idioma_id":4,"titulo":"Changes in vertebral laminae across the cervico-dorsal transition of a well-preserved rebbachisaurid (Dinosauria: Sauropoda) from the Cenomanian of Patagonia, Argentina","resumen":"This research present new materials assignable to Rebbachisauridae, recovered from the Huincul Formation, Neuquén Group, near Villa El Chocón, Neuquén Province. The rebbachisaurid remains correspond to a  single, partially articulated, and exceptionally-preserved skeleton, which includes cervical and dorsal vertebrae, thoracic ribs, scapula, and a humerus. The importance of studying complete serial elements of the skeleton (e.g., vertebral series) lies on the ability to track specific elements (i.e., landmarks), which are useful to unambiguously recognize homologous structures. In this regard, the preserved cervico-dorsal series described herein gives remarkable anatomical and systematic information, allowing the recognition of the transitional morphology, topology, and extent of the vertebral laminae. The well-preserved remains of Rebbachisauridae presented herein provided new information of the morphological changes in the cervicodorsal transition above the  zygodiapophyseal plane, specifically those occurred in the sprl and the eprl. A close relationship between MMCH-Pv 49 and Cathartesaura anaerobica is possible, but comparisons are limited to a single vertebra at the moment. The affinities of MMCH-Pv 49 will be resolved with further  discoveries.","palabras_clave":"Rebbachisauridae|Pectoral series|Vertebral laminae|Vertebral fossae|Patagonia|Cretaceous"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88060,"idioma_id":4,"titulo":"Influence of precipitation, landscape and hydrogeomorphic lake features on pelagic allochthonous indicators in two connected ultraoligotrophic lakes of North Patagonia","resumen":"We investigated the terrestrial influence on two chained deep ultraoligotrophic lakes of North Patagonia (Argentina) through the seasonal analysis of two pelagic allochthonous indicators: i) water color, as a proxy of allochthonous dissolved organic matter in lakes; and ii) the color to chlorophyll a ratio (Color:Chla), as an indicator of the relationship between allochthonous and autochthonous carbon pools.We also evaluated the potential transfer pathways of the allochthonous dissolved organic matter into the pelagic food webs of these deep lakes, including the natural zooplankton &#948;13C in the analysis. The dynamics of the allochthonous indicators were related to the precipitation regime,water level fluctuations, and hydrogeomorphic and catchment features of lakes Moreno East and Moreno West. The water color (absorbance at 440 nm) was extremely low (","palabras_clave":"Water color|Allochthony|Zooplankton isotopic carbon signatures|Hydrogeomorphic features"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88061,"idioma_id":4,"titulo":"Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin-induced diabetes","resumen":"Diabetes Metab Res Rev. 2011 Sep 15. doi: 10.1002\/dmrr.1296. [Epub ahead of print]Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin-induced diabetes.Bianchi MS, Calvo V, Chasseing NA, Lago N, Libertun C, Montaner AD, Lux-Lantos VA.SourceInstituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.AbstractBACKGROUND: We have shown that oligodeoxynucleotide IMT504 improved blood glucose and islet beta-cell content in streptozotocin (STZ) induced diabetic rats, inducing early expression of progenitor markers. Here we determined the effect of IMT504 on islet infiltration and on immunomodulatory proteins indoleamine 2,3-dioxygenase (IDO) and TNF-&#945;&#8201;-&#8201;stimulated gene\/protein 6 (TSG-6) in islets of STZ-diabetic rats, at the time of progenitor markers expression.METHODS: Male rats were i.p. injected with STZ (60&#8201;mg\/kg body weight (BW)) or citrate buffer (Control) (day 1). Starting on day 4, STZ animals were daily-treated with saline (STZ-Saline) or IMT504 (20&#8201;mg\/kg BW\/day sc, STZ-IMT504) and killed after two consecutive decreases in blood glucose. Islet area and insulin expression, CD3 (T lymphocytes), CD68 (macrophages), IDO and TSG-6 immunostainings were determined. Islet infiltration was also evaluated by haematoxylin staining.RESULTS: STZ induced diabetes in rats, with an important decrease in islet area, which was reversed by IMT504. Diabetes development did not involve islet infiltration, determined by haematoxylin and by the absence of significant T lymphocyte and macrophage presence. IMT504 did not induce changes in these parameters. IDO was not expressed in Controls; the percentages of IDO-positive islets were very low and similar in STZ-Saline and STZ-IMT504. Scarce TSG-6 was expressed in all groups, without significant differences.CONCLUSIONS: IMT504 improved insulin content but did not alter IDO or TSG-6 staining in islets of STZ-diabetic rats, suggesting that they do not participate in the IMT504-induced repair process. IMT504 did not per se modify leukocyte presence in islets of diabetic rats. Copyright © 2011 John Wiley &amp; Sons, Ltd","palabras_clave":"Oligodeoxynucleotide |IMT504|Diabetes|Islet"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88062,"idioma_id":4,"titulo":"Effects of Orexins A and B on Expression of Orexin Receptors and Progesterone Release in Luteal and Granulosa Ovarian Cells","resumen":"&nbsp;Orexin-A and orexin-B are neuropeptides controlling sleep-wakefulness, feeding and neuroendocrine functions via their G protein-coupled receptors, orexin-1R and orexin-2R. They are synthesized in the lateral&nbsp; via their G protein-coupled receptors, orexin-1R and orexin-2R. They are synthesized in the lateral hypothalamus and project throughout the brain. Orexins and orexin receptors have also been described outside the brain. Previously we demonstrated the presence of both receptors in the ovary, their increased expression during proestrous afternoon and the dependence on the gonadotropins. Here we studied the effects of orexins on the mRNA expression of both receptors, by quantitative real-time PCR, on luteal cells from superovulated rat ovaries and granulosa cells from diethylstilbestrol-treated rat ovaries. Effects on progesterone secretion were also measured.&nbsp;In luteal cells, 1 nM of either orexin-A or orexin-B decreased progesterone secretion. Orexin-A treatment&nbsp;increased expression of both orexin-1R and orexin-2R mRNA. The effect on orexin-1R mRNA expression was abolished by an orexin-1R selective receptor antagonist SB-334867 and the effect on orexin-2RmRNA expression was abolished by a selective orexin-2R antagonist JNJ-10397049. Orexin-B did not modify orexin-1R mRNA expression, but increased orexin-2R mRNA expression. The effect of orexin-B on orexin-2R was abolished by a selective orexin-2R antagonist. Neither the expression of orexin receptors nor progesterone secretions by&nbsp;granulosa cells were affected by orexins. FSH, as positive control, increased both steroid hormones secretion, but did not induce the expression of OX receptors in granulosa cells isolated from late preantral\/early antral follicles. Finally in ovaries obtained immediately after sacrifice, the expression of orexin-1R and orexin-2R was 39fice, the expression of orexin-1R and orexin-2R was higher in superovulated rat ovaries compared to control or diethylstilbestrol treated rat ovaries. A selective presence and function of both orexinergic receptors in luteal and granulosa cells is described, suggesting that the orexinergic system may have a functional role in the ovary. © 2012 Published by Elsevier B.V.","palabras_clave":"orexinas|ovario|receptores|progesterona"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88063,"idioma_id":4,"titulo":"Bisphenol-A imprinting of Growth hormone-dependent sexually dimorphic liver      \t proteins and genes in female rats.","resumen":"The hypothalamic-growth hormone (GH)-liver axis represents a new concept in endocrine regulation of drug toxicity. Preponderant sex differences are found in liver gene expression, mostly dependent on the sexually dimorphic pattern of GH secretion which is set during the neonatal period by gonadal steroids. We tested if imprinting of GH-dependent sexually dimorphic liver enzymes and proteins was perturbed by neonatal Bisphenol A (BPA) treatment in female rats. Female rats were sc injected with BPA (50 or 500 ìg\/50 ìL) or castor oil vehicle from postnatal day 1 to 10. At five months rats serum prolactin, pituitary GH and serum and liver insulin growth factor-I (IGF-I) were measured by RIA. Major urine proteins were determined by electrophoresis. Liver Cyp2c11, Cyp2c12, Adh1, Hnf6, and Prlr mRNA levels were determined by real time PCR. Pituitary GH content and liver IGF-I concentration were increased by neonatal BPA treatment, indicating partial masculinization of the GH axis in treated females. GH-dependent female predominant liver enzyme genes (Cyp2c12 and Adh1) and a transcription factor (Hnf6) were dowregulated, while there were no changes in a male predominant gene (Cyp2c11) or protein (MUP). Our findings indicate that perinatal exposure to BPA may alter the sexually dimorphic capacity of the liver to metabolize drugs and steroids. ","palabras_clave":"Bisphenol-A|Growth hormone|Proteins|Genes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88064,"idioma_id":4,"titulo":"EFFECTS OF GABA B AGONISTS AND ANTAGONISTS ON GLYCEMIA REGULATION IN MICE","resumen":"ABSTRACT g-Aminobutyric acid (GABA) inhibits insulin secretion through GABA B receptors in pancreatic b-cells. We investigated whether GABA B receptors participated in the regulation of glucose homeostasis in vivo. BALB\/c mice acutely pre-injected with the GABA B agonist baclofen (7.5 mg\/kg, ip) presented glucose intolerance and diminished insulin secretion during a glucose tolerance test (GTT, 2 g\/kg body weight, ip). The GABA B antagonist 2-hydroxysaclofen (15 mg\/kg, ip) improved the GTT and reversed the baclofen effect. Also a slight increase in insulin secretion was observed with 2-hydroxysaclofen. In incubated islets 1.10-5M baclofen inhibited 20 mM glucose-induced insulin secretion and this effect was reversed by coincubation with 1.10-5M 2-hydroxysaclofen. In chronically-treated animals (18 days) both the agonist (5 mg\/kg\/day ip) and the antagonist (10 mg\/kg\/day ip) induced impaired GTTs; the antagonist, but not the agonist, also induced a decrease in insulin secretion. No alterations in insulin tolerance tests, body weight and food intake were observed with the treatments. In addition glucagon, insulin-like growth factor I, prolactin, corticosterone and growth hormone, other hormones involved in glucose metabolism regulation, were not affected by chronic baclofen or 2-hydroxysaclofen. In islets obtained from chronically injected animals with baclofen, 2-hydroxysaclofen or saline (as above), GABA B2 mRNA expression was not altered. Results demonstrate that GABA B receptors are involved in the regulation of glucose homeostasis in vivo. Treatment with agonists or antagonists, given acutely or chronically, altered glucose homeostasis and insulin secretion alerting to the need to evaluate glucose metabolism during the clinical use of these drugs. ","palabras_clave":"GABA B|AGONISTS|ANTAGONISTS|GLYCEMIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88065,"idioma_id":5,"titulo":"Deforestación, expansión agropecuaria y dinámica demográfica en el Chaco Seco Argentino durante la década de los noventa","resumen":"El Gran Chaco Argentino constituye la mayor extensión forestal y el más grande reservorio de biomasa del hemisferio sur extratropical. El sector situado al oeste de la isohieta de 700 mm, constituye el ambiente del Chaco Semiárido o Seco, ocupando sectores de las provincias de Salta, Chaco, Formosa, Santiago del Estero y Tucumán. Esta área del Chaco tiene una gran diversidad biológica y se caracteriza por un acelerado proceso de deforestación, en especial para la implantación del cultivo de soja.                                                                   Concebido como un territorio vacío en términos demográficos, prevalece sobre el Chaco la idea de pobreza y marginalidad. Los cambios que están ocurriendo en los márgenes de este ambiente en relación con la expansión de la frontera agropecuaria, afecta a las poblaciones locales, transformando su dinámica demográfica. Este trabajo, por ello, trata de mostrar la magnitud de la deforestación y el impacto del avance de la frontera agropecuaria (especialmente del cultivo de soja) sobre la dinámica demográfica del área.                                                                 ","palabras_clave":"Deforestación|Expansión agrícola|Dinámica demográfica|Chaco Seco"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88066,"idioma_id":4,"titulo":"Agriculture and Cattle Frontier Advance and Variation of Poverty in the North of the 'Gran Chaco Argentino' during the 1990s","resumen":"El Gran Chaco Argentino GCA es la mayor extensión forestal y el mayor reservorio de biomasa del país y del hemisferio sur extratropical (Gasparri, Grau y Manghi 2008). Durante la década de los ?90, buena parte de esta región ha estado sometida a un intenso cambio en el uso del suelo. Junto a un rápido proceso de deforestación se ha producido una paulatina sustitución de los cultivos tradicionales y un avance sin precedentes de la frontera agropecuaria. El algodón, la caña de azúcar y el poroto cedieron parte de sus superficies al avance del cultivo de granos, especialmente de soja, cuya implantación fue también la que motorizó el avance de la frontera agropecuaria (Paolasso; Krapovickas y Gasparri, en prensa).Sin embargo, en 2001, las áreas más pobres del GCA coincidían en buena medida con el área de expansión agropecuaria.Este contraste entre el dinamismo del sector agropecuario en la región, que se supone debería generar prosperidad entre la población, contrasta con las condiciones de pobreza de buena parte de la población regional. Por ello, en este trabajo se busca responder uno de los interrogantes asociados con este contraste: ¿Existe alguna relación entre el avance de la frontera agropecuaria y las condiciones de pobreza de la población? Puede conjeturarse que el dinamismo del sector agropecuario en buena parte del Chaco durante los noventa no ha implicado una mejora en las condiciones de vida de la población.Se utilizan para el análisis del avance de la frontera agropecuaria datos provenientes de los censos agropecuarios nacionales 1988 y 2002 referidos a superficie implantada según cultivos y cabezas de ganado según departamentos. La superficie implantada se ha agrupado según grandes masas de cultivos, distinguiéndose en forma individual la superficie implantada con soja. Para evaluar la evolución de la pobreza se ha utilizado el Índice de Privación de Medios de Vida (IPMV) (Meichtry, Paolasso, Mignone, Ortíz de D?Arterio, Fantin y Bolsi, 2005) a partir de datos obtenidos de los censos nacionales de población, hogares y viviendas 1991 y 2001.Los resultados muestran que junto a un crecimiento generalizado del área cultivada, sobre todo con soja, especie que ha pasado a ser dominante en la región, y de los planteles ganaderos, ha habido un aumento generalizado de las condiciones de pobreza de la población del Chaco Argentino. Sin embargo, existen fuertes diferencias espaciales en los niveles de pobreza.De esta manera, los cambios en el sector agropecuario no han implicado una mejora en las condiciones de vida de la población local. Habrían sido las características del proceso de avance de la frontera agropecuaria las que posibilitaron esta situación: una fuerte presencia de empresarios foráneos, grandes explotaciones, la mecanización de los procesos y débil reinversión de las ganancias en la región.","palabras_clave":"Agricultura|Frontera Agropecuaria|Chaco Argentino|Pobreza"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88067,"idioma_id":4,"titulo":"Floral scents learned inside the honey bee hive have a long-lasting effect on recruitment","resumen":"Floral scents learned during the waggle dance, a signal through which honeybees provide nestmateswith spatial information on foraging sites, are an important component of recruitment. Forager bees canbe reactivated to go to previously exploited food sources by perceiving scents they learned at the flowerswithin the dance context. Here, we tested whether floral scents experienced not at the foraging site, butvia scented nectar inside the nest, can influence subsequent recruitment. We determined that bees thatwere exposed to scented food while in the hive tended to follow dances in which the recruiting beepresented the same odour experienced 8 days earlier. Moreover, a higher proportion of bees with in-hiveexperience were successfully recruited to the feeding sites scented with the experienced odours than tothe feeding sites scented with novel odours. This bias in recruitment was independent of the time thatthe bees spent following dances. These findings suggest that associative memories acquired even as earlyas the first week of adult life were responsible for a variation in recruitment. We discuss our results interms of the adaptive value of the long-term olfactory memories acquired inside the nest as a facilitatorto decode the spatial information transmitted in the honeybee dance.","palabras_clave":"COMMUNICATION|HONEYBEE|OLFACTORY LEARNING|WAGGLE DANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88068,"idioma_id":4,"titulo":"Estradiol, progesterone and prolactin modulate mammary gland morphogenesis in adult female plains vizcacha (Lagostomus maximus)","resumen":"We studied for the first time the mammary  gland morphogenesis and its hormonal modulation by immunolocalizing  estradiol, progesterone and prolactin  receptors (ER, PR and PRLR) in adult females of Lagostomus  maximus, a caviomorph rodent which shows a  pseudo-ovulatory process at mid-gestation. Mammary  ductal system of non-pregnant females lacks expression of  both ERa and ERb. Yet throughout pregnancy, ERa and  ERb levels increase as well as the expression of PR. These  increments are concomitant with ductal branching and  alveolar differentiation. Even though mammary gland  morphology is quite similar to that described for other  rodents, alveolar proliferation and differentiation are  accelerated towards the second half of pregnancy, once  pseudo-ovulation had occurred. Moreover, this exponential  growth correlates with an increment of both progesterone  and estradiol serum-induced pseudo-ovulation. As expected,  PR and PRLR are strongly expressed in the alveolar  epithelium during pregnancy and lactation. Strikingly,  PRLR is also present in ductal epithelia of cycling glands  suggesting that prolactin function may not be restricted to  its trophic effect on mammary glands of pregnant and  lactating females, but it also regulates other physiological processes in mammary glands of non-pregnant animals. In  conclusion, this report suggests that pseudo-ovulation at  mid-gestation may be associated to L. maximus mammary  gland growth and differentiation. The rise in progesteroneand  estradiol-induced pseudo-ovulation as well as the  increased expression of their receptors, all events that  correlate with the development of a more elaborated and  differentiated ductal network, pinpoint a possible relation  between this peculiar physiological event and mammary  gland morphogenesis.","palabras_clave":"ESTRADIOL|PROGESTERONA|PROLACTINA|DESARROLLO DE LA GLÁNDULA MAMARIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88069,"idioma_id":4,"titulo":"Influence of period-doubling bifurcations in the appearance of border collisions for a ZAD-strategy controlled buck converter","resumen":"The first period-doubling bifurcation of a dc\u2013dc buck converter controlled by a zero-average dynamic strategy is studied in detail. Owing to the saturation of the duty cycle, this bifurcation is followed by a border-collision bifurcation, which is the main mechanism to introduce instability and chaos in the circuit. The multiparameter analysis presented here leads to a complete knowledge of the relationship between these two bifurcations. The results are obtained by using a frequency-domain approach for the study of period-two oscillations in maps.","palabras_clave":"buck converters|ZAD-strategy|bifurcations|maps"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88070,"idioma_id":4,"titulo":"On the study of bifurcations in delay-differential equations: A frequency-domain approach","resumen":"An improved version of a frequency-domain approach to study bifurcations in delay-dfferential equations is presented. The proposed methodology provides information about the frequency, amplitude, and stability of the orbit emerging from Hopf bifurcation. We apply this method to different schemes of the delayed van der Pol oscillator. The time-delay dependence can appear intrinsically because of the system dynamics or can be intentionally introduced in a feedback loop. Also, a discussion about system controllability and observability is given for a proper and rigorous application of the frequency domain technique. Collateral findings involving some types of static bifurcations are included for completeness.","palabras_clave":"van der Pol|bifurcación de Hopf|sistemas con retardo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88071,"idioma_id":4,"titulo":"Generalized Hopf bifurcation in a frequency domain formulation","resumen":"The multiplicity problem of limit cycles arising from a weak focus is addressed. The proposed methodology is a combination of the frequency domain method to handle some degenerate Hopf bifurcations with the powerful tools of the singularity theory. The frequency domain approach uses the harmonic balance method to study the existence of periodic solutions. On the other hand, the singularity theory provides the conditions and formulas for the classification problem of the unfolding of the singularity in terms of the distinguished and auxiliary parameters. A classical example introduced by Bautin is shown in which the multiplicity of limit cycles is recovered by using this type of hybrid methodology and standard software in the continuation of periodic solutions (LOCBIF and XPPAUT). For small amplitude limit cycles, the proposed methodology gives accurate results.","palabras_clave":"BIFURCACION|MULTIPLICIDAD|OSCILACIONES|CONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88072,"idioma_id":5,"titulo":"Las TIC como problemática de la teoría sociológica. Una problematización teórica de la comunicación digitalizada desde la teoría general de sistemas sociales autorreferenciales y autopoiéticos","resumen":"Este trabajo presenta una discusión teórica sobre las Tecnologías de la Información y la Comunicación (TIC) desde los intereses de la teoría sociológica general y bajo los supuestos de la Teoría General de Sistemas Sociales Autorreferenciales y Autopoiéticos (TGSSAA), que acentúa la centralidad sociológica de la comunicación y establece una teoría de la sociedad moderna y mundial. Este enfoque sitúa a las TIC más allá de las reflexiones sobre la relación tecnología y sociedad, y las trata dentro del problema general del orden social. El trabajo propone entonces: 1) relevar tres obstáculos epistemológicos (tecnologicismo, sociologicismo, sobrecarga diacrónica) que bloquean el trabajo teórico general sobre este fenómeno, 2) conceptualizar las transformaciones estructurales generadas por la digitalización de las TIC, Internet y la convergencia tecnológica en el campo de la propagación de la comunicación, y 3) encuadrarlas dentro de una teoría de la sociedad. Los supuestos de los cuales partimos afirman que del robustecimiento y mundialización de la digitalización, la convergencia tecnológica e Internet ha emergido un medio de comunicación. Este medio digital, interconectado y nodulado transformó las estructuras de propagación de la sociedad y posibilitó tanto el agenciamiento comunicativo de nodos informáticos como la síntesis comunicativa entre emisiones y recepciones remotas.","palabras_clave":"TGSS|TIC|comunicación|digital"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88073,"idioma_id":4,"titulo":"Protein stability and dynamics modulation: the case of human frataxin","resumen":"Frataxin (FXN) is an &#945;\/&#946; protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative formation of crucial interactions between helix &#945;1, helix &#945;2, and the C-terminal region (CTR) of the protein.   In this work we quantitatively explore these relationships using a purified recombinant fragment hFXN90-195. This variant shows the hydrodynamic behavior expected for a monomeric globular domain. Circular dichroism, fluorescence, and NMR spectroscopies show that hFXN90-195 presents native-like secondary and tertiary structure. However, chemical and temperature induced denaturation show that CTR truncation significantly destabilizes the overall hFXN fold. Accordingly, limited proteolysis experiments suggest that the native-state dynamics of hFXN90-195 and hFXN90-210 are indeed different, being the former form much more sensitive to the protease at specific sites.   The overall folding dynamics of hFXN fold was further explored with structure-based protein folding simulations. These suggest that the native ensemble of hFXN can be decomposed in at least two substates, one with consolidation of the CTR and the other without consolidation of the CTR. Explicit-solvent all atom simulations identify some of the proteolytic target sites as flexible regions of the protein.   We propose that the local unfolding of CTR may be a critical step for the global unfolding of hFXN, and that modulation of the CTR interactions may strongly affect hFXN physiological function.","palabras_clave":"Frataxina humana|Modulación de la dinámica|Estabilidad proteíca"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88074,"idioma_id":4,"titulo":"Chia (Salvia Hispanica l.) Oil extraction: study of processing parameters","resumen":"The processing parameters related with chia oil extraction employing screw press have not been studied yet. A BoxeBehnken experimental design was used to study the optimization process by response surface analysis. The independent variables considered were seed moisture content, restriction die, screw press speed and barrel temperature, while the response variables measured were oil yield, fines content in oil and oil quality (acidity, peroxide index, K232, K270, values, antioxidant activity and total tocopherol content). Since chemical quality data of chia seeds oil pressed at different conditions was not affected, the response was optimize to maximize oil yield. The results suggested that 0.113 g\/g dry solids (0.101 g\/g seed), 6 mm restriction die, 20 rpm screw press speed and 30 °C barrel temperature were the best processing combination to maximize oil yield.","palabras_clave":"CHIA|OIL QUALITY|OIL YIELD|SCREW PRESS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88075,"idioma_id":4,"titulo":"Incorporation of several additives into gluten free breads: Effect on dough properties and bread quality","resumen":"The objective of this work was to assess the effect of emulsifiers, hydrocolloids and enzymes on glutenfreedough rheology and thermal properties and bread quality, while relating dough properties parametersto bread technological quality. Breads were based on rice flour, cassava starch and full-fat active soyflour, with 65% or 75% (flour-starch basis) of water incorporation. Additives used were emulsifiers(diacetyl tartaric acid ester of monoglycerides ? DATEM and sodium stearoyl lactylate ? SSL), enzymes(glucose oxidase and a-amylase) and hydrocolloids (xanthan gum, carboxymethylcellulose, alginateand carrageenan). Results showed that additive incorporation modified dough behavior, evidenced bydifferent calorimetric and rheological properties. Besides, the electrophoretic pattern of dough extractedproteins changed with glucose oxidase addition. These modifications resulted in breads with differentcharacteristics, such as specific volume, firmness and firming rate, and crumb structure. Nonetheless,they did not necessarily show better quality parameters than the control bread. The control dough displayedgood performance for obtaining gluten-free breads of acceptable volume, crumb structure and,principally, with lower hardening rate during storage. Contrary to widespread opinion, this work showsthat the presence of additives is not essential for gluten-free bread production. This fact provides newperspectives to the gluten free market at the moment of selecting raw materials and technologicalparameters, reducing production costs and facilitating gluten free products development.","palabras_clave":"gluten free|bread"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88076,"idioma_id":4,"titulo":"Partial-baking process on gluten-free bread: Impact of hydrocolloid addition","resumen":"The objectives of this work were to assess the impact of partial-baking process on gluten-free breads, and to study the effect of carboxymethylcellulose and xanthan gum on this process. Part-baking process consisted in an initial baking-step (25 min), storage (7 days, 4º C), and final baking-step (15 min). Conventional baking consisted in one baking-step (40 min). Carboxymethylcellulose (CMC) and xanthan gum (XG) were added. Bread specific volume (SV), crumb hardness and image analysis were assessed on final products of both processes and intermediate products. Breads were stored at room temperature for 72 h and crumb firming and amylopectin retrogradation were monitored. Freezable water (FW) fraction was determined on fresh and stored samples by using DSC. Part-baked breads had lower SV and higher crumb hardness. No SV diminution was observed during cold storage. Hydrocolloids -especially CMC- had a positive effect on these parameters. During bread storage at 25º C crumb hardness increased but this trend was counteracted by hydrocolloid addition. Crumb structure was more homogeneous for CMC-breads, and part-baked breads showed smaller cell area. FW showed no significant differences among processes, formulations or storage time. Amylopectin cristallization was higher for part-baking breads. Interrupted baking process diminished final bread quality, but negative effects can be counteracted by hydrocolloid addition. Part-baking process is suitable for obtaining gluten-free breads, stored for a week at 4°C, so they are appropriated for home consumption.","palabras_clave":"partial baked bread|hydrocolloid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88077,"idioma_id":4,"titulo":"Influence of enzyme active and inactive soy flours on cassava and corn starch properties","resumen":"The aim of this work was to study the influence of enzyme active and inactive soy flours on the properties of cassava and corn starches. Four starch\/soy flour composites were evaluated: cassava\/active soy flour (Cas\/AS), cassava\/inactive soy flour (Cas\/IS), corn\/active soy flour (Corn\/AS) and corn\/inactive soy flour (Corn\/IS). Starch gelatinization occurred at 58.67 ºC for Cas and at 64.19 ºC for corn; gelatinization occurred at higher temperatures when soy flours were present, while &#916;H diminished. The presence of AS reduced 80% the retrogradation enthalpy of Cas and 40% that of corn. Cas presented lower pasting temperature than corn starch (67.8 ºC and 76.8 ºC, respectively) and higher peak viscosity (427.9 and 232.8 BU, respectively). The pasting properties of both starches were drastically reduced by soy flours, and this effect was more noticeable in Cas; AS had higher effect than IS. X-ray diffractometry of retrograded samples showed that both starches retrogradation (mainly that of Cas) was reduced when AS was added. Tan &#948; values decreased with AS addition to corn, but they increased when added to Cas. The images obtained using confocal laser scanning microscopy (CLSM) showed that IS was distributed as large aggregates, whereas AS distribution was more homogeneous, especially when incorporated to Cas. These results show that cassava starch interacts specifically with active soy flour (mainly in native state). The delaying effect of AS on cassava starch retrogradation was clearly shown. This finding could be useful in obtaining gluten-free breads of high quality and low retrogradation rate.","palabras_clave":"CASSAVA STARCH|CORN STARCH|PROTEINS|SOY FLOURS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88078,"idioma_id":4,"titulo":"Enzymes Action on Wheat-Soy Dough Properties and Bread Quality","resumen":"High levels of soy flour added to wheat bread produce negative effects on gluten network formation, dough properties, and on bread final quality. The objective of this study was to assess the influence of three enzymes, transglutaminase (TG), glucose oxidase (GOX), and endoxylanase (XYL), on dough properties and final quality of high-protein breads. The addition of TG and GOX increased the mixing stability and maximum resistance of dough, decreased its extensibility, and produced stronger and more consistent dough samples. XYL incorporation produced opposite results. XYL addition and the lowest GOX dose increased bread volume significantly and decreased initial crumb firmness, while high doses of TG (0.3%) produced detrimental effects on bread volume and crumb firmness. In conclusion, XYL and GOX 0.001% addition improved the final quality of soy-fortified breads, but XYL was the best additive to improve dough properties, bread volume, and quality.","palabras_clave":"dough|bread|wheat |soy|enzymes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88079,"idioma_id":5,"titulo":"Efectos de diferentes fracciones de harinas de trigo pan obtenidas con molino industrial sobre la calidad de galletitas dulces","resumen":"Se evaluaron las propiedades físico-químicas y calidad galletitera de distintas fracciones de harina de trigo pan obtenidas por molienda industrial, y se compararon con una harina de trigo pan obtenida por molienda experimental. Se determinó que los procedimientos de molienda incidieron sobre el contenido de almidón dañado y el porcentaje de cenizas en las harinas. Se observó un incremento en el contenido de almidón dañado y una disminución en el contenido de cenizas. Se registraron variaciones significativas en el perfil de capacidad de retención de solventes (SRC) e Índice de sedimentación en dodecil sulfato de sodio (IS-SDS). El factor galletita (FG), la dureza, la rugosidad superficial y la fracción de área de agrietamiento de las galletitas mostraron cambios significativos según la fracción de harina utilizada. El proceso de molienda afectó significativamente la capacidad de las harinas para la elaboración de galletitas. El análisis de componentes principales permitió discriminar entre las diferentes fracciones de harinas a partir de las evaluaciones fisicoquímicas y reológicas, lo que indica que la combinación de ambos tipos de determinaciones permite predecir el comportamiento tecnológico de una harina para la elaboración de galletitas","palabras_clave":"Trigo|fracciones|galletitas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88080,"idioma_id":5,"titulo":"Indicadores de calidad de las harinas de trigo: índice de calidad industrial y su relación con ensayos predictivos","resumen":"El objetivo de este trabajo fue estudiar y evaluar la capacidad de diferentes parámetros para predecir la calidad de las harinas de trigo, analizando las relaciones existentes entre éstos y el índice de calidad industrial (ICI). Se utilizaron siete muestras de harina de trigo provistas por la CEI Barrow. Se determinaron parámetros relacionados con la calidad del grano de trigo, la molienda y la composición de las harinas. Además, se llevaron a cabo ensayos relacionados con el comportamiento de las masas (ensayo farinográfico y alveográfico) y se elaboró pan. Se calculó el ICI para cada una de las muestras y se estudió su relación con pruebas de predicción y ensayos de calidad. El ICI mostró correlaciones significativas y positivas con el contenido de macropolímero de glutenina, la extensibilidad alveográfica y el tiempo de desarrollo de la masa. Estas relaciones podrían resultar beneficiosas en la evaluación de la aptitud de las harinas para la elaboración de diferentes productos panificados, ya que constituyen determinaciones más sencillas y no requieren de equipamiento de alta tecnología ni grandes cantidades de muestra","palabras_clave":"trigo|calidad industrial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88081,"idioma_id":4,"titulo":"Enzymatic modifications of pea protein and its application in protein-cassava and corn starch gels","resumen":"The interactions between starch and proteins during processing influence pasting and rheological  properties of starch and produce modifications on starch gel structure. Enzymatic modifications have  been proposed for overcoming the limitations of using proteins as food ingredients. This work aimed to  study the impact of native and enzymatically modified pea proteins on the properties of proteinestarch  (from cassava or corn) gels. Pea protein isolate (PPI) was incubated with endopeptidase (AL) or microbial  transglutaminase (TG). Pasting profile, rheological behaviour and water retention capacity of proteine  starch gels were analyzed. Protein (native and enzymatically modified) incorporation increased the  viscosity of both corn and cassava starches during gel preparation. However, the hydrolyzed protein  reduced drastically the increment of viscosity of proteinestarch gels. The addition of PPI led to corn  starch network that shifted from an elastic-like nature to a more viscous-like, whereas the opposite  effect was observed in cassava gel network. TG- and AL-treated proteins led to a decrease of both G0 and  G00 moduli of proteinestarch gels, and AL-treated proteins showed the highest decrease on these  parameters. Hydrolyzed proteins also favoured the syneresis of the proteinecorn starch gel, whereas  crosslinked proteins tended to reduce it. Enzymatic modifications of pea proteins affected significantly  pasting and rheological properties of proteine starch gels.","palabras_clave":"Pea|cassava|corn|gels"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88082,"idioma_id":4,"titulo":"COLOUR ASSESSMENT ON BREAD WHEAT AND TRITICALE FRESH PASTA","resumen":"Although durum wheat is the cereal of choice for pasta production, in many areas ofArgentina pasta is made from bread wheat, since durum wheat is cultivated only in a small region of the country. The purpose of this work was to determine the influence of different bread flours on the colour of laminated fresh pasta. Triticale flour was also studied. In addition, ash, protein, and protein fractions of each flour were measured. Also, the formulation was modified using different gluten, starch, and water concentrations. Pasta lightness and redness were affected mainly by the ash content, while yellowness was affected by the protein content of different flours. A similar effect was found when the formulation was substituted for starch and gluten, due to protein dilution and concentration, respectively. Albumins and globulins correlated with a&#8727; component, while gliadins, soluble and insoluble glutenins correlated with b&#8727; component; however, only glutenins presented correlation with colour score(CS = [L&#8727; + (b&#8727; × 2)]\/20). The greatest amount of water added to the dough produced decrease of lightness and an increase of redness and yellowness of pasta samples. The overall ANOVA revealed that the greatest sources of variation for pasta colour were the different flours used, in comparison with the effect of starch and gluten substitution, and with the addition of different amounts of water.","palabras_clave":"pasta|bread wheat"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88083,"idioma_id":4,"titulo":"Comparing galaxy populations in compact and loose groups of galaxies","resumen":"Aims. We perform a comparison of the properties of galaxies in compact groups, loose groups and in the field  to deepen our understanding of the physical mechanisms acting upon galaxy evolution in different environments.  Methods. We select samples of galaxies in compact groups identified by McConnachie et al., loose groups identified  by Zandivarez & Martinez, and field galaxies from the Sloan Digital Sky Survey. We compare properties of the galaxy populations in these different environments: absolute magnitude, colour,   size, surface brightness, stellar mass and concentration. We also study the fraction of red and  early type galaxies, the luminosity function, the colour-luminosity and luminosity-size relations.  Results. The population of galaxies in compact groups differ from that of loose groups and the field.  The fraction of read and early type galaxies is higher in compact groups.  On average, galaxies in compact groups are systematically smaller, more concentrated and  have higher surface brightness than galaxies in the field and in loose groups.   For fixed absolute magnitude, or fixed surface brightness, galaxies in compact groups are smaller.  Conclusions. The physical mechanisms that transform galaxies into earlier types could be more effective  within compact groups given the high densities and low velocity dispersion that characterise  that particular environment, this could explain the large fraction of red and early type   galaxies we found in compact groups. Galaxies inhabiting compact groups have undergone a major  transformation compared to galaxies that inhabit loose groups.","palabras_clave":"GALAXIES|FUNDAMENTAL PARAMETERS|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88084,"idioma_id":5,"titulo":"ILUMINACION NATURAL DE SALAS DE PROPAGACIÓN AGÁMICA","resumen":"Se presentan los resultados lumínicos obtenidos  gracias a la aplicación de un Sistema Pasivo de Iluminación Natural en una Sala  de propagación agámica de plantas. Se evaluaron, por una parte, la distribución  de iluminancias dentro de la sala, para tres diferentes alturas y tres  distintos momentos del día, y por otra parte, el aporte lumínico en flujo del  sistema Anidólico instalado. Finalmente, se calculó cuál es el posible ahorro  energético que el sistema generaría a partir de su uso para la complementación  de iluminación artificial. Los resultados mostraron la utilización de un  Sistema Anidólico puede redundar en un importante ahorro de la energía eléctrica utilizada  diariamente por los sistemas de iluminación artificial","palabras_clave":"ILUMINACIÓN NATURAL|PRODUCCIÓN DE PLANTAS|AHORRO ENERGÉTICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88085,"idioma_id":4,"titulo":"Effect of preparation method on the properties of nanostructured gadolinia-doped ceria materials for IT-SOFCs","resumen":"            In order to obtain different  morphologies, nanostructured Gd0.1Ce0.9O1.95  (GDC10) and Gd0.2Ce0.8O1.90 (GDC20) were  synthesized using three different chemical methods: reverse microemulsion (RM),  cation complexation (CC) and template-filling (TF). The resulting materials  were characterized by synchrotron radiation X-ray diffraction (SR-XRD), by  X-ray absorption near-edge spectroscopy (XANES) and by scanning and high  resolution transmission electron microscopy (SEM and HRTEM). All nanostructured  mixed oxides were found to have a cubic crystal phase (Fm3m space group) with an average crystallite sizes ranging from  9.6 to 13.2 nm. Tubular nanostructured GDC10 obtained using a template-filling  method exhibited the largest specific surface area (97 m2g-1)  while the lowest values were obtained using the cation complexation method (23  m2g-1). XANES results indicated that the extent of  reduction of these materials was small. Nevertheless, the Ce3+ ion  was detected. Preliminary catalytic studies showed that the tubular  nanostructured (TF) GDC10 samples exhibited better catalytic activity for CH4  oxidation than the CC and RM nanopowders of the same chemical composition.","palabras_clave":"Gadolinia |Ceria|XANES|TEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88086,"idioma_id":4,"titulo":"Avidity and subtyping of specific antibodies applied to the indirect assessment of heterologous protection against Foot and Mouth Disease Virus in cattle","resumen":"Serological&nbsp;&nbsp; assessment&nbsp;&nbsp; of&nbsp;&nbsp; the&nbsp;&nbsp; heterologous&nbsp;&nbsp; response&nbsp;&nbsp; among&nbsp;&nbsp; Foot-and-Mouth&nbsp;&nbsp; Disease&nbsp;&nbsp; Virus&nbsp;&nbsp; (FMDV) strains&nbsp;&nbsp; is&nbsp;&nbsp; mainly&nbsp;&nbsp; performed&nbsp;&nbsp; by&nbsp;&nbsp; virus&nbsp;&nbsp; neutralization&nbsp;&nbsp; test&nbsp;&nbsp; (VNT),&nbsp;&nbsp; liquid&nbsp;&nbsp; phase&nbsp;&nbsp; blocking&nbsp;&nbsp; ELISA&nbsp;&nbsp; and&nbsp;&nbsp; com-plement&nbsp;&nbsp; &#64257;xation&nbsp;&nbsp; assay.&nbsp;&nbsp; In&nbsp;&nbsp; this&nbsp;&nbsp; study&nbsp;&nbsp; two&nbsp;&nbsp; high-throughput&nbsp;&nbsp; ELISA&nbsp;&nbsp; techniques,&nbsp;&nbsp; avidity&nbsp;&nbsp; and&nbsp;&nbsp; IgG&nbsp; subtype ELISA,&nbsp;&nbsp; were&nbsp;&nbsp; developed&nbsp;&nbsp; and&nbsp;&nbsp; used&nbsp;&nbsp; to&nbsp;&nbsp; further&nbsp;&nbsp; characterize&nbsp;&nbsp; heterologous&nbsp;&nbsp; antibody&nbsp;&nbsp; responses&nbsp;&nbsp; in&nbsp;&nbsp; cattle&nbsp;&nbsp; dur-ing&nbsp; vaccination&nbsp;&nbsp; and&nbsp;&nbsp; challenge.&nbsp;&nbsp; Both&nbsp;&nbsp; assays&nbsp;&nbsp; were&nbsp;&nbsp; applied&nbsp;&nbsp; to&nbsp;&nbsp; a&nbsp;&nbsp; set&nbsp;&nbsp; of&nbsp;&nbsp; previously&nbsp;&nbsp; characterized&nbsp;&nbsp; sera&nbsp;&nbsp; from animals&nbsp;&nbsp; immunized&nbsp;&nbsp; with&nbsp;&nbsp; an&nbsp;&nbsp; inactivated&nbsp;&nbsp; A24&nbsp;&nbsp; Cruzeiro\/Brazil\/55&nbsp;&nbsp; (A24&nbsp;&nbsp; Cruzeiro)&nbsp;&nbsp; strain&nbsp;&nbsp; monovalent&nbsp;&nbsp; FMDV vaccine&nbsp;&nbsp; and&nbsp;&nbsp; challenged&nbsp;&nbsp; with&nbsp;&nbsp; the&nbsp;&nbsp; heterologous&nbsp;&nbsp; A\/Argentina\/2001&nbsp;&nbsp; (A\/Arg\/01)&nbsp;&nbsp; strain.&nbsp;&nbsp; Single&nbsp;&nbsp; dilution&nbsp;&nbsp; avid-ity&nbsp; ELISA&nbsp;&nbsp; assessment&nbsp;&nbsp; showed&nbsp;&nbsp; that&nbsp;&nbsp; animals&nbsp;&nbsp; that&nbsp;&nbsp; were&nbsp;&nbsp; protected&nbsp;&nbsp; against&nbsp;&nbsp; A\/Arg\/01&nbsp;&nbsp; challenge&nbsp;&nbsp; had&nbsp;&nbsp; higher avidity&nbsp;&nbsp; antibodies&nbsp;&nbsp; to&nbsp; this&nbsp;&nbsp; heterologous&nbsp;&nbsp; strain&nbsp;&nbsp; than&nbsp;&nbsp; non-protected&nbsp;&nbsp; cattle.&nbsp;&nbsp; Animals&nbsp;&nbsp; with&nbsp;&nbsp; low&nbsp;&nbsp; or&nbsp;&nbsp; even&nbsp; unde-tectable&nbsp;&nbsp; anti-A\/Arg\/01&nbsp;&nbsp; serum-neutralizing&nbsp;&nbsp; titers&nbsp;&nbsp; that&nbsp;&nbsp; passed&nbsp;&nbsp; the&nbsp;&nbsp; heterologous&nbsp;&nbsp; challenge&nbsp;&nbsp; presented&nbsp;&nbsp; higher IgG1\/IgG2&nbsp; ratio&nbsp;&nbsp; than&nbsp;&nbsp; non-protected&nbsp;&nbsp; animals.&nbsp;&nbsp; In&nbsp; this&nbsp;&nbsp; study,&nbsp;&nbsp; the&nbsp; three&nbsp;&nbsp; assessments&nbsp;&nbsp; (VNT&nbsp;&nbsp; and&nbsp;&nbsp; both&nbsp;&nbsp; ELISAs)discriminated&nbsp;&nbsp; between&nbsp;&nbsp; protected&nbsp;&nbsp; and&nbsp;&nbsp; not&nbsp;&nbsp; protected&nbsp;&nbsp; animals&nbsp;&nbsp; against&nbsp;&nbsp; a&nbsp;&nbsp; heterologous&nbsp;&nbsp; challenge.&nbsp;&nbsp; The&nbsp;&nbsp; combi-nation&nbsp; of&nbsp;&nbsp; these&nbsp;&nbsp; techniques&nbsp;&nbsp; may&nbsp;&nbsp; be&nbsp;&nbsp; applied&nbsp;&nbsp; to&nbsp; complement&nbsp;&nbsp; current&nbsp;&nbsp; indirect&nbsp;&nbsp; serological&nbsp;&nbsp; vaccine-matching assessments.&nbsp;&nbsp; The&nbsp;&nbsp; measurement&nbsp;&nbsp; of&nbsp;&nbsp; these&nbsp;&nbsp; qualitative&nbsp;&nbsp; parameters&nbsp;&nbsp; may&nbsp;&nbsp; provide&nbsp;&nbsp; additional&nbsp;&nbsp; information to&nbsp;&nbsp; understand&nbsp;&nbsp; the&nbsp;&nbsp; mechanisms&nbsp;&nbsp; underlying&nbsp;&nbsp; FMD&nbsp;&nbsp; heterologous&nbsp;&nbsp; responses&nbsp;&nbsp; and&nbsp;&nbsp; the&nbsp;&nbsp; induction&nbsp;&nbsp; of&nbsp; cross-protection&nbsp;&nbsp; in&nbsp; cattle.","palabras_clave":"FOOT AND MOUTH DISEASE VIRUS|CROSS PROTECTION|AVIDITY|SUBTYPES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88087,"idioma_id":4,"titulo":"A genome-wide regulatory framework identifies maize pericarp color1 controlled genes","resumen":"Pericarp Color1 (P1) encodes an R2R3-MYB transcription factor responsible for the accumulation of insecticidal flavones in maize (Zea mays) silks and red phlobaphene pigments in pericarps and other floral tissues, which makes P1 an important visual marker. Using genome-wide expression analyses (RNA sequencing) in pericarps and silks of plants with contrasting P1 alleles combined with chromatin immunoprecipitation coupled with high-throughput sequencing, we show here that the regulatory functions of P1 are much broader than the activation of genes corresponding to enzymes in a branch of flavonoid  biosynthesis. P1 modulates the expression of several thousand genes, and ;1500 of them were identified as putative direct targets of P1. Among them, we identified F2H1, corresponding to a P450 enzyme that converts naringenin into  2-hydroxynaringenin, a key branch point in the P1-controlled pathway and the first step in the formation of insecticidal C-glycosyl flavones. Unexpectedly, the binding of P1 to gene regulatory regions can result in both gene activation and repression. Our results indicate that P1 is the major regulator for a set of genes involved in flavonoid biosynthesis and a minor modulator of the expression of a much larger gene set that includes genes involved in primary metabolism and production of other specialized compounds.","palabras_clave":"Maize|Flavonoid|P1 transcription factor"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88088,"idioma_id":4,"titulo":"Effects of thymol and isoeugenol feed supplementation on quail adult performance, egg characteristics and hatchling success","resumen":"1. A study was conducted to evaluate whether the feed supplementation with thymol or isoeugenolcan alter Japanese quail growth rate and final body weight, the female onset of puberty, hen-day egg production and the physical and chemical characteristics of the egg, as well as its potentialalteration of their offspring hatchability.2. From 4 to 16 weeks of age, birds from each cage (1 male: 3 females) were assigned to 1 of 3treatments that differed in the supplement added to the feed: control, thymol or isoeugenol (400mg\/kg). The average ages (days) at first egg lay (FIRST), at 25% egg production (A25% EP), at50% egg production (A50% EP) and weekly and cumulative hen-day egg production (HDEP) were calculated. In addition, physical and chemical characteristics of the eggs, their fertility andhatchability were also evaluated for each group.3. Feed supplementation did not significantly affect growth rate, final body weight, egg productionparameters, fertility and physical characteristics of egg or most of the fatty acid components of theegg´s yolk.4. The group treated with isoeugenol showed an increase in the percentage of palmitoleic fatty acidcompared to the control, with thymol group showing intermediates values.5. Both thymol and isoeugenol supplemented groups reached an increased number of hatchlings of18.8 % and 11.8 %, respectively compared to their control counterparts.6. The improvement in the hatchling success of the eggs from the thymol and isoeugenolsupplemented groups without a negative impact on their performance may have important economicimplications for future breeding programs, particularly if these effects generalize from quail to other more commercially important poultry species, like chickens or turkeys.","palabras_clave":"Dietary supplementation|Japanese quail|thymol isoeugenol|hatchability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88089,"idioma_id":4,"titulo":"Silica-based hybrid coatings for corrosion protection of carbon steel. Part I: Effect of pretreatment with phosphoric acid","resumen":"  This work studies the synthesis and characterization of hybrid organic-inorganic coatings based on silica to improve the corrosion resistance of carbon steel. Hybrid organicinorganic silica sol-gel coatings were obtained by dipping in an organically modified silica sol synthesized through hydrolysis and condensation of 3-glicidoxipropyl-trimetoxisilano (GPTMS) and tetraethoxysilane (TEOS) in acidic catalysis. The coatings were doped with a cerium salt (Ce(NO3)3·6H2O) and loaded with silica nanoparticles in order to improve both barrier effect and the anticorrosive behavior of the coatings by the inhibitory effect of cerium. Prior to the application of the coating, some samples were treated with a phosphoric acid 2 % v\/v in order to improve coating adherence. A two layered coating was applied onto AISI 1010 carbon steel, the outer containing a cerium salt and the inner one with silica nanoparticles without the cerium salt, producing homogeneous and cracks-free films. Raman spectroscopy was used to characterize the compounds present in the surface of steel after pretreatment with phosphoric acid. Microstructural characterization of coatings was performed by means of Scanning Electron Microscopy (SEM). The evolution with time of the protective properties of films was studied by electrochemical impedance spectroscopy (EIS), providing quantitative information of the role of the pre-treatment. Electrochemical behavior in each stage of the corrosion processes was modeled by equivalent circuits. Additionally, films adhesion was evaluated by nanoscratch demonstrating that the phosphate treatment improves adhesion of the hybrid coating.3)3·6H2O) and loaded with silica nanoparticles in order to improve both barrier effect and the anticorrosive behavior of the coatings by the inhibitory effect of cerium. Prior to the application of the coating, some samples were treated with a phosphoric acid 2 % v\/v in order to improve coating adherence. A two layered coating was applied onto AISI 1010 carbon steel, the outer containing a cerium salt and the inner one with silica nanoparticles without the cerium salt, producing homogeneous and cracks-free films. Raman spectroscopy was used to characterize the compounds present in the surface of steel after pretreatment with phosphoric acid. Microstructural characterization of coatings was performed by means of Scanning Electron Microscopy (SEM). The evolution with time of the protective properties of films was studied by electrochemical impedance spectroscopy (EIS), providing quantitative information of the role of the pre-treatment. Electrochemical behavior in each stage of the corrosion processes was modeled by equivalent circuits. Additionally, films adhesion was evaluated by nanoscratch demonstrating that the phosphate treatment improves adhesion of the hybrid coating.","palabras_clave":"AISI 1010|PHOSPHORIC ACID TREATMENT|EIS|CORROSION|HYBRID COATING|SOL-GEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88090,"idioma_id":4,"titulo":"Detrital zircon U-Pb ages of metasedimentary rocks from Sierra de Valle Fértil: Entrapment of Middle and Late Cambrian marine successions in the deep roots of the Early Ordovician Famatinian arc","resumen":"We obtained detrital zircon ages from three metasedimentary rocks with siliciclastic protoliths that were buried to paleodepths of 20e27 km during Early Ordovician Famatinian arc magmatism. In all three samples, UePb zircon age distributions are polymodal but the dominant peaks make well-defined clusters, matching the ages of orogenic systems that characterize West Gondwana. The most prominent peaks of constituent age populations at 520 Ma, 600 Ma, and 1050 Ma reflect derivation from sources that are characteristic of the West Gondwana margin. Moreover, grains with Meso- and Paleo-Proterozoic ages appear as small fractions (sedimentary units in the nearby Cuyania Terrane.","palabras_clave":"DETRITAL ZIRCONS|GEOCHRONOLOGY|METASEDIMENTARY ROCKS|FAMATINIAN ARC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88091,"idioma_id":4,"titulo":"Effects of tour boats on dolphin activity examined with sensitivity analysis of Markov chains","resumen":"                                  In Patagonia, Argentina, watching dolphins, especially dusky dolphins (Lagenorhynchus obscurus),  is a new tourist activity. Feeding time decreases and time to return to feeding after feeding is abandoned and  time it takes a group of dolphins to feed increase in the presence of boats. Such effects on feeding behavior  may exert energetic costs on dolphins and thus reduce an individual?s survival and reproductive capacity  or maybe associated with shifts in distribution. We sought to predict which behavioral changes modify the  activity pattern of dolphins the most. We modeled behavioral sequences of dusky dolphins with Markov chains.  We calculated transition probabilities from one activity to another and arranged them in a stochastic matrix  model. The proportion of time dolphins dedicated to a given activity (activity budget) and the time it took a  dolphin to resume that activity after it had been abandoned (recurrence time) were calculated. We used a  sensitivity analysis of Markov chains to calculate the sensitivity of the time budget and the activity-resumption  time to changes in behavioral transition probabilities. Feeding-time budget was most sensitive to changes in  the probability of dolphins switching from traveling to feeding behavior and of maintaining feeding behavior.  Thus, an increase in these probabilities would be associated with the largest reduction in the time dedicated  to feeding. A reduction in the probability of changing from traveling to feeding would also be associated with  the largest increases in the time it takes dolphins to resume feeding. To approach dolphins when they are  traveling would not affect behavior less because presence of the boat may keep dolphins from returning to  feeding. Our results may help operators of dolphin-watching vessels minimize negative effects on dolphins.(Lagenorhynchus obscurus),  is a new tourist activity. Feeding time decreases and time to return to feeding after feeding is abandoned and  time it takes a group of dolphins to feed increase in the presence of boats. Such effects on feeding behavior  may exert energetic costs on dolphins and thus reduce an individual?s survival and reproductive capacity  or maybe associated with shifts in distribution. We sought to predict which behavioral changes modify the  activity pattern of dolphins the most. We modeled behavioral sequences of dusky dolphins with Markov chains.  We calculated transition probabilities from one activity to another and arranged them in a stochastic matrix  model. The proportion of time dolphins dedicated to a given activity (activity budget) and the time it took a  dolphin to resume that activity after it had been abandoned (recurrence time) were calculated. We used a  sensitivity analysis of Markov chains to calculate the sensitivity of the time budget and the activity-resumption  time to changes in behavioral transition probabilities. Feeding-time budget was most sensitive to changes in  the probability of dolphins switching from traveling to feeding behavior and of maintaining feeding behavior.  Thus, an increase in these probabilities would be associated with the largest reduction in the time dedicated  to feeding. A reduction in the probability of changing from traveling to feeding would also be associated with  the largest increases in the time it takes dolphins to resume feeding. To approach dolphins when they are  traveling would not affect behavior less because presence of the boat may keep dolphins from returning to  feeding. Our results may help operators of dolphin-watching vessels minimize negative effects on dolphins.","palabras_clave":"activity budget|dusky dolphins|sensitivity analysis|stochastic matrix models"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88092,"idioma_id":4,"titulo":"Diving for food: a switch of foraging strategy of dusky dolphins in Argentina","resumen":"During winter, dusky dolphins were observed in coordinated diving apparently in a feeding activity, contrasting with the surface feeding observed during summer.  The aim of this work consisted in analyzing the diving activity as an alternative foraging strategy in Argentine dusky dolphins, based on sequential analysis. The study area was Golfo Nuevo, located in Northern Patagonia, Argentina. Random transects were surveyed by a research boat from 2001 to 2007. During behavioral sampling, group members were observed continuously and the predominant activity was recorded at 2-min intervals. Six predominant activities were identified. Each 2-min interval was classified according to the activity at the previous interval (preceding activity), the activity at the interval (following activity), and the season (cold or warm). Z-score were calculated and then used to construct sequence diagrams. An association between diving and milling behavior was observed. This could be another foraging tactics different to the surface foraging sequences and this could be related with the distribution or abundance of preys. ","palabras_clave":"DIVING|FORAGING STRATEGY|BEHAVIORAL SEQUENCES|DUSKY DOLPHINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88093,"idioma_id":4,"titulo":"Bottlenose dolphins at the southern extreme of the south-western Atlantic: local population decline?","resumen":"The management scheme of Marine Protected Areas (MPAs) includes monitoring protocols but such activities are not always carried out. This is the case for Golfo San Jose´, a MPA in northern Patagonia, Argentina. It was created in 1975 for the protection of the southern right whale (Eubalaena australis) breeding grounds. Other components of the system, such as dolphin populations have received little attention. This study is the first attempt to estimate sighting rates, group size and overall abundance of a bottlenose dolphin (Tursiops truncatus) population in Golfo San Jose´ and adjacent areas after 30 years. An analysis of the seasonal sighting rates indicates that bottlenose dolphins were present in the study area throughout the year but a decline in group size and abundance and major shift in distribution was detected when compared with previous published reports. The settlement of the MPA failed to secure the persistence of the bottlenose dolphin population within its boundaries.  Possible explanations for the detected decline are addressed including increased natural mortality, human induced mortality  and disturbance, resources depletion and environmental shift.","palabras_clave":"bottlenose dolphins|local population decline|Marine Protected Areas|Tursiops truncatus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88094,"idioma_id":4,"titulo":"High-Performance Control of a DC-DC Z-Source Converter used for an Excitation Field Driver","resumen":"The electromechanical interface is a Synchronous  Machine because its field winding permits direct management of the magnetization during speed variations. For systems with  a common dc-link for the drive and excitation converters, the efficiency is increased if the excitation drive has boosting  capability. It is shown that with the proposed control strategy the Z-source converter is suitable for this application, becoming a better alternative than the typically usedbuckconverter. The Z-source converter in combination with the proposed multi-loop  control law can achieve the desired voltage reference swing and high-performance tracking. An analytical comparison between the dominant losses of the buck topology, typically used in FESS, and the Z-source converter shows that the latter has higher efficiency for this application. The parameters of the  converter prototype were experimentally identified and used to implement the proposed controller. The control strategy uses the two duty cycles as manipulated variables, one to allow tracking fast changes in the reference signal and the other to adapt the system to the slow changes. The combined action on both inputs contribute to the compensation of the non-minimum  phase response of the Z-converter. Experimental results show the potential of the controller for tracking typical FESS application waveforms.Será publicado en el número de Junio de 2012.","palabras_clave":"DC-DC POWER CONVERSION|Z-SOURCE CONVERTER|FLYWHEELS|AC GENERATOR EXCITATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88095,"idioma_id":4,"titulo":"Real-time Low-Distortion Digital PWM Modulator for Switching Converters","resumen":"A compensation scheme to reduce the inherent baseband distortion in   \t\tuniform PWM modulators (UPWM) is presented in this paper. The method is   \t\tbased on real-time mapping of the switching times of UPWM to those of   \t\tnatural PWM that, as it is well-known, exhibits far less in-band   \t\tdistortion. Two alternatives are presented: one based on an exact,   \t\tanalytic algorithm recently reported in the literature, and another one   \t\tthat uses an artificial neural network (ANN). Both methods are designed   \t\tfor arbitrary, band-limited modulating signals and they are not   \t\trestricted to single-frequency sinusoids, as other techniques presented   \t\tin the literature. Simulation results and experimental measurements of a   \t\tFPGA implementation demonstrate a significant reduction of the   \t\tdistortion in real-time applications. The performance of both   \t\talternatives is compared for several modulating signals, and the results   \t\tof industry-standard distortion tests are also reported. Finally, some   \t\tguidelines for choosing the best alternative for ASIC or FPGA   \t\timplementations are provided","palabras_clave":"FIELD PROGRAMMABLE GATE ARRAYS|HARMONIC DISTORTION|PULSE WIDTH MODULATION|SWITCHING CONVERTERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88096,"idioma_id":5,"titulo":"Bacterias probióticas como suplemento dietario promisorio para la salud","resumen":"El ecosistema intestinal constituye un microambiente complejo donde las células inmunes eintestinales están en constante interacción con la microbiota normal.La maduración y la modulación del sistema inmune intestinal se encuentran influenciadas por el establecimiento de la microbiota comensal, cuyo equilibrio puede ser afectado (benéficamente o no) por microorganismos que ingresan a través de la alimentación.Entre estos microorganismos se encuentran los probióticos que se caracterizan por conferir un efecto beneficioso en la salud del hospedador. Entre las propiedades atribuidas a estosmicroorganismos, podemos mencionar la capacidad de reforzar la barrera intestinal y la demejorar la respuesta inmune. Utilizando modelos experimentales en ratón, se demostró que los microorganismos probióticos y\/o las leches fermentadas que los contienen pueden modular el sistema inmune sistémico y de mucosa, proporcionando protección contra bacterias enteropatógenas y actuando como adyuvantes de la respuesta inmune sistémica frente a una vacunación en hospedadores inmunodeprimidos por malnutrición","palabras_clave":"PROBIOTICOS|LECHE FERMENTADA PROBIOTICA|SISTEMA INMUNE|MALNUTRICION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88097,"idioma_id":4,"titulo":"Evaluation of the Anti-Inflammatory effect of milk fermented by a strain of IL-10 producing Lactococcus lactis using a murine model of Crohn's disease","resumen":"Background\/Aims: Interleukin-10 (IL-10) is the most important anti-inflammatory cytokine involved in inflammatory bowel diseases. However, oral treatment with IL-10 is difficult because of&nbsp; its low half-life in the gastrointestinal tract, and systemic treatments have been associated with undesirable side effects. The aim of this paper was to evaluate the antiinflammatory effect of the administration of milk fermented by Lactococcus lactis strains that produce IL-10 using a murine model of Crohn's disease. Methods: Milk fermented by IL-10-producing strains of L. lactis strains were given to mice treated with trinitrobenzenesulfonic acid to induce colitis and different physiological and immune parameters were evaluated. Results: Mice that received milk fermented by L. lactis strains producing IL-10 in the cytoplasm or secreted to the product showed lower damage scores in their large intestines, decreased IFN-y levels in their intestinal fluids and lower translocation to liver, compared to mice receiving milk fermented by the wild-type strain or those not receiving any treatment. Conclusions: The administration of milk fermented with IL-10-producing L. lactis was effective in preventing chemically induced colitis in mice and could lead to the development of novel therapeutical foods.","palabras_clave":"INTERLEUKIN-10|LACTOCOCCUS LACTIS|TNBS|INFLAMMATORY BOWEL DISEASES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88098,"idioma_id":4,"titulo":"Outer membrane vesicles from Brucella abortus promote bacterial internalization by human monocytes and modulate their innate immune response","resumen":"Outer membrane vesicles (OMVs) released by some gram-negative bacteria have been shown to exert immunomodulatory effects that favor the establishment of the infection. The aim of the present study was to assess the interaction of OMVs from Brucella abortus with human epithelial cells (HeLa) and monocytes (THP-1), and the potential immunomodulatory effects they may exert. Using confocal microscopy and flow cytometry, FITC-labeled OMVs were shown to be internalized by both cell types. Internalization was shown to be partially mediated by clathrin-mediated endocytosis. Pretreatment of THP-1 cells with Brucella OMVs inhibited some cytokine responses (TNF-alpha and IL-8) to E. coli LPS, Pam3Cys or flagellin (TLR4, TLR2 and TLR5 agonists, respectively). Similarly, pretreatment with Brucella OMVs inhibited the cytokine response of THP-1 cells to B. abortus infection. Treatment of THP-1 cells with OMVs during IFN-gamma stimulation reduced significantly the inducing effect of this cytokine on MHC-II expression. OMVs induced a dose-dependent increase of ICAM-1 expression on THP-1 cells and an increased adhesion of these cells to human endothelial cells. The addition of OMVs to THP-1 cultures before the incubation with live B. abortus resulted in increased numbers of adhered and internalized bacteria as compared to cells not treated with OMVs. Overall, these results suggest that OMVs from B. abortus exert cellular effects that promote the internalization of these bacteria by human monocytes, but also downregulate the innate immune response of these cells to Brucella infection. These effects may favor the persistence of Brucella within host cells.","palabras_clave":"BRUCELLA|OUTER MEMBRANE VESICLES|IMMUNOMODULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88099,"idioma_id":4,"titulo":"A review on second- and third-order multivariate calibration applied to chromatographic data","resumen":"Quantitative analytical works developed by processing second- and third-order chromatographic data are reviewed. The various modes in which data of complex structure can be measured are discussed, with chromatographic separation providing either one or two of the data dimensions. This produces second order data (matrices from uni-dimensional chromatography with multivariate detection or from twodimensionalchromatography) or third-order data (three-dimensional data arrays from two-dimensionalchromatography with multivariate detection). The available algorithms for processing these data are classified and discussed, regarding their ability to cope with the ubiquitous phenomenon of retention time shifts from run to run. A summary of relevant works applying this combination of techniques is presented, with focus on quantitative analytical results. Special attention is paid to works achieving the full potentiality of the multidimensional data, i.e., the second-order advantage.","palabras_clave":"SECOND- AND THIRD-ORDER CHROMATOGRAPHIC DATA|MULTIVARIATE CALIBRATION|SECOND-ORDER ADVANTAGE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88100,"idioma_id":4,"titulo":"A novel nylon membrane-rhodamine 6G spirocyclic phenylthiosemicarbazide derivative system as a fluorimetric probe for mercury (II) ion","resumen":"A highly sensitive and selective probe for the fluorimetric determination of mercury ion traces in aqueous solution is proposed. The probe is based on the mercury-promoted ring opening of the spirolactam moiety of a rhodamine 6G spirocyclic phenylthiosemicarbazide derivative (FC1) retained in nylon membranes. It is demonstrated that the chemodosimeter preserves its sensor ability, displaying intense fluorescence in the presence of Hg(II) after being immobilized on the nylon surface and reacting with the mercury ion solution via a simple syringe procedure. The advantages of this proposal are: (1) the use of an easily affordable solid support which is able to immobilize the FC1 molecular probe without involving a covalent bond, (2) the consumption of a very small volume of organic reagent,dramatically reducing the environmental impact, and (3) the development of a solid phase system potentially useful as a main component for designing chemical sensors capable of providing continuous real-time information. In order to obtain higher and stable fluorescence signals, both experimental and instrumental variables were optimized. Thus, a simple and sensitive fluorescence method for the determination of mercury ion was established. The limit of detection calculated according to 1995 IUPAC Recommendations was 0.4 ng\/mL (lower than the toxic levels in drinking water for human consumption, established by several regulatory agencies), the relative standard deviation was 2.3% (n =6) at a level of 3.5 ng mL1, and the sampling rate was about 15 samples per hour. The study of the potential interference from common cations demonstrated a remarkable selectivity for the investigated metal ion. The viability of determining Hg(II) ion residues in real water samples was successfully evaluated through the recovery study of several spiked environmental water samples from different locations.","palabras_clave":"SPECTROFLUORIMETRY|CHEMICAL PROBE|MERCURY ION|NYLON MEMBRANE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88101,"idioma_id":4,"titulo":"A different interpretation of the annual and semiannual anomalies on the magnetic activity over the Earth","resumen":"The H component of the magnetic field measured at the terrestrial surface presents several periodic signals caused by changes in the ring current that flows within the terrestrial magnetosphere. One of the most important of them is associated to the phenomenon known as the Semiannual Anomaly which produces two significant minima during the equinoxes. This phenomenon is global, i.e., every observatory registers a similar effect independently of the hemisphere where it is located. A second important signal is due to the phenomenon known as the Annual Anomaly that produces significant different values for solstices, with a particular feature: the effect depends on the hemisphere where the observatory is located, with maximum during local summer. In spite of the time since their discoveries (more than a hundred years ago) the physical processes  behind them are still open to discussion. In this work we present a new physical interpretation for the combined effects of both anomalies. The main concept developed is that along the year the shape of the magnetospheric cavities within which the ring current flows is deformed according to the geometric configuration between the solar wind and the magnetosphere.","palabras_clave":"geomagnetic semi-annual anomaly|geomagnetic annual anomaly|solar wind-magnetosphere interaction|ring current"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88102,"idioma_id":4,"titulo":"The geomagnetic semiannual anomaly on the four Dst-fundamental observatories - Dependences with Sun-Earth physical parameters","resumen":"The semiannual anomaly (also known as semiannual variation) on the magnetic  activity is a phenomenon that produces clear minima during March and September and  maxima in June and December on the horizontal components of the geomagnetic field.  This phenomenon has been known since the middle of the nineteenth century, but in spite  of the accumulation of measurements and the development of three theoretical models,  a conclusive physical explanation for it has not been developed. The usual approach to  study the semiannual anomaly is by means of geomagnetic indices like the disturbance storm time, Dst, which is based on combining measurements registered on four magnetic observatories. This work follows a different approach based on the raw horizontal components registered at the four observatories. The analyses performed aimed to study and assess the impact of several external parameters, characteristics of the Sun-Earth  environment, on the semiannual anomaly. The influence of the global geomagnetic activity level, the solar activity level, the solar magnetic polarity, and the rising\/declining phase of the solar radiation cycle is analyzed in detail. The most important finding is that the semiannual anomaly is always present and that none of the previously mentioned  parameters significantly favor the development of it. A second result is the presence of a 27 day signal superposed to the semiannual anomaly which is significantly affected by the solar activity level.","palabras_clave":"geomagnetic anomaly|Dst index|sun-earth magnetosphere interaction|ring current"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88103,"idioma_id":4,"titulo":"Sexually dimorphic expression of receptor-alpha in the cerebral cortex of neonatal Caiman latirostris (Crocodylia: Alligatoridae)","resumen":"In mammals, estrogens have been described as endocrine and paracrine modulators of neuronal differentiation and synapse formation. However, the functional role of circulating estrogens and the distribution of estrogen receptors (ERs) in the cerebral cortex of reptiles have not been clearly established. Caiman latirostris (C. latirostris) is a South American species that presents temperature-dependent sex determination (TSD). By using immunohistochemistry, we have studied the distribution of ER&#945; in the cerebral cortex of neonatal caimans. We studied brain samples from ten-day-old TSD-females and TSD-males and from female caimans that were administered estradiol during embryonic development (hormone-dependent sex determination, HSD-females). ER&#945; was detected in the medial (MC), dorsal (DC) and lateral (LC) cortices. ER&#945; expression in the MC showed sex-associated differences, being significantly greater in TSD-females compared to TSD-males. Interestingly, the highest ER&#945; expression in the MC was exhibited by HSD-females. In addition, the circulating levels of estradiol were significantly higher in females (both TSD and HSD) than in TSD-males. Double immunostaining showed that ER&#945; is expressed by neural precursor cells (as detected by ER&#945;\/doublecortin or ER&#945;\/glial fibrillary acidic protein) and mature neurons (ER&#945;\/neuron-specific nuclear protein). Our results demonstrate that the expression of ER&#945; in the neonatal caiman cortex is sexually dimorphic and is present in the early stages of neuronal differentiation.","palabras_clave":"CEREBRAL CORTEX|CAIMAN LATIROSTRIS|IMMUNOHISTOCHEMISTRY|ESTROGEN RECEPTOR-ALPHA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88104,"idioma_id":4,"titulo":"Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts","resumen":"Abstract  ABSTRACT:  BACKGROUND: Regulation of surface antigenic variation in Giardia lamblia is controlled post-transcriptionally by an RNA-interference (RNAi) pathway that includes a Dicer-like bidentate RNase III (gDicer). This enzyme, however, lacks the RNA helicase domain present in Dicer enzymes from higher eukaryotes. The participation of several RNA helicases in practically all organisms in which RNAi was studied suggests that RNA helicases are potentially involved in antigenic variation, as well as during Giardia differentiation into cysts.  RESULTS:  An extensive in silico analysis of the Giardia genome identified 32 putative Super Family 2 RNA helicases that contain almost all the conserved RNA helicase motifs. Phylogenetic studies and sequence analysis separated them into 22 DEAD-box, 6 DEAH-box and 4 Ski2p-box RNA helicases, some of which are homologs of well-characterized helicases from higher organisms. No Giardia putative helicase was found to have significant homology to the RNA helicase domain of Dicer enzymes. Additionally a series of up- and down-regulated putative RNA helicases were found during encystation and antigenic variation by qPCR experiments. Finally, we were able to recognize 14 additional putative helicases from three different families (RecQ family, Swi2\/Snf2 and Rad3 family) that could be considered DNA helicases.  CONCLUSIONS:  This is the first comprehensive analysis of the Super Family 2 helicases from the human intestinal parasite G. lamblia. The relative and variable expression of particular RNA helicases during both antigenic variation and encystation agrees with the proposed participation of these enzymes during both adaptive processes. The putatives RNA and DNA helicases identified in this early-branching eukaryote provide initial information regarding the biological role of these enzymes in cell adaptation and differentiation.","palabras_clave":"RNA\/DNA helicases|Giardia lamblia|Encystation|Antigenic variation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88105,"idioma_id":4,"titulo":"In silico analysis of Trypanosomatids' helicases.","resumen":"Trypanosomatids are unicellular protozoan parasites that cause many diseases in animals, including humans, and plants. These early divergent eukaryotes have many singular structures and processes, including the hyper-modified ?base J?, a mitochondrial DNA network, RNA editing and trans-splicing; all of these unique features involve a wide variety of specific DNA\/RNA helicases. In this work, the genomes of trypanosomatids were analyzed by data mining, searching for genes coding for DNA\/RNA helicases. Specific motifs and full-length sequences from all families present in the helicase´s superfamilies (SFs) 1 and 2 were used as baits for genome analyses. A total of 328 putative helicases were identified; 204 genes were assigned to the SF2, 42 genes to the SF1 and 76 genes remain unclassified. Eight specie-specific SF2 helicases were also found; T. cruzi has three DEAD-box and one DEAH\/RHA specific helicases, while L. major has three Swi2\/Snf2 and T. brucei has only one RigI helicase. Finally, in order to identify helicases that could be used as future therapeutic targets, all obtained genes were compared with those present in the human genome. Forty-two helicases underrepresented in the human genome were identified; constituting 16 orthologs groups from L. major, T. brucei and T. cruzi.","palabras_clave":"TRYPANOSOMATIDS|HELICASES|DRUG TARGETS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88106,"idioma_id":4,"titulo":"Grass endophyte symbiosis: A neglected aboveground interaction with multiple belowground consequences","resumen":"          Most  terrestrial plants form symbiosis with a large variety of microorganisms that  can be major determinants of morphological and physiological host traits that,  ultimately, affect the structure and function of communities. Epichloae fungal  endophytes (Clavicipitaceae) are widespread symbionts of grasses that asymptomatically  inhabit aerial host tissues, and confer defense to herbivores and tolerance to  multiple stresses. Research on symbionts of plants has focused on soil  organisms such as nitrogen-fixing bacteria and mycorrhizal fungi, although  recent studies suggest that endophytes of great agronomic interest can also  generate major shifts in the belowground subsystem. We conducted a  meta-analysis to examine the available knowledge on the effects of endophytes  on the soil. Our objective was to provide a synthesis of existing data that,  comprehensively and quantitatively, evaluates the different pathways by which  the grass?endophyte symbiosis may affect belowground components and processes,  and highlights gaps in knowledge relevant to agroecosystem management. The presence  of endophyte was found to reduce root biomass and mycorrhizal colonization of  plants. In turn, a significant stimulation of root exudates by endophytes was  detected. Effects of endophytes on soil respiration and litter decomposition were  not significant. No pattern was found in the response of the soil fauna to  endophyte presence. Our review revealed that we still need to improve our  understanding about the impact of endophytes on other mutualistic symbionts.  The grass?endophyte symbiosis is a promising interaction that, like those involving  nitrogen-fixing bacteria and mycorrhizal fungi, may become an important tool  for sustainable agriculture. ","palabras_clave":"Neotyphodium endophytes|Mutualism|Soil biota |Soil processes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88107,"idioma_id":4,"titulo":"Germination requirements of two sheep-preferred grasses (Hordeum comosum and Koeleria vurilochensis var. patagonica) from semiarid Patagonian steppes","resumen":"Grazing by domestic exotic herbivores on native vegetation in Patagonian steppes has led to the deterioration of forage resources, where grasses are replaced by shrubs, and preferred grasses by nonpreferred ones. Therefore, attempts at breeding and regeneration should start by identifying species with potential forage capability. Two perennial high-preferred species are the focus of this paper: Hordeum comosum and Koeleria vurilochensis. For the first time, we studied their morphological traits, dormancy level, and their temperature and water germination requirements, through thermal- and hydrotime models. H. comosum seeds were solid, large and heavy, while K. vurilochensis seeds were soft, small and light. Neither light-quality nor alternating temperature affected the dormancy level in seeds of both species. Seeds of H. comosum and K. vurilochensis required, respectively, 768.74  Ch and 2217.89  Ch to germinate; alternatively, base temperature was higher for H. comosum than for K. vurilochensis. The hydrotime required by H. comosum was 26 MPah and 110 Mpah for K. vurilochensis but, base wáter potential was  0.99 MPa and  1.45 MPa, respectively. For all the conditions, H. comosum displayed a higher germination rate compared to K. vurilochensis seeds. Deeper knowledge on the morphological and germination traits of seeds is a key step toward breeding and restoration of forage potential species.","palabras_clave":"Hydrotime|Native forage species|Seed traits|Temperature requirement"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88108,"idioma_id":4,"titulo":"Kinetic study of canola oil and tocopherol extraction. Parameter comparison of nonlinear models","resumen":"In this work a statistical method of comparison was used in order to compare the parameters of a modified diffusion model representing the kinetics of canola oil and tocopherol extraction. The model takes into account an initial stage where solvent removes the oil from the surface of the ground seed by washing. Kinetic tests were carried out in a batch extractor at different temperatures (from 25 to 60°C) using hexane as solvent. Tocopherol concentration in the extracted oil was determined by HPLC.   The parameter comparison showed that the portion extracted during the washing stage was only temperature-dependent in the case of tocopherol extraction, whereas the effective diffusion coefficients were temperature-dependent in oil and tocopherol extraction. The diffusivities ranged from 1.3 10-12 to 3.0 10-12 m2s-1 and from 1.6 10-12 to 2.3 10-12 m2s-1 for oil and tocopherol extraction, respectively. The oil and tocopherol extraction activation energy was 19.1 kJ.mol-1 and 8.1 kJ.mol-1, respectively.","palabras_clave":"Canola oil extraction|tocopherol extraction|nonlinear model|diffusion coefficient|parameter comparison"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88109,"idioma_id":5,"titulo":"Estudio del efecto del pretratamiento hidrotérmico sobre el rendimiento y calidad de aceites de canola y girasol","resumen":"El objetivo del presente trabajo es evaluar el efecto de un pretratamientohidrotérmico sobre el rendimiento en la extracción deaceites de canola y de dos híbridos de girasol.Se realizó un pretratamiento hidrotérmico a semillas molidas decanola y de dos híbridos de girasol (uno de cáscara negra y otrode cáscara estriada) y se determinó el rendimiento en aceite ycaracterísticas de calidad del aceite (valor de acidez e índice deperóxidos). El contenido inicial de aceite de las especies fue de45,3%; 49,5% y 43,7% (base seca) para canola, girasol negroy girasol estriado, respectivamente. El pretratamiento hidrotérmicooriginó un aumento significativo en el rendimiento deaceite en ambos híbridos de girasol, mientras que en canola eseparámetro no sufrió modificaciones substanciales. Al mismotiempo, se observó un incremento en los valores de índice deperóxidos en girasol y en valor de acidez en todas las muestras.","palabras_clave":"Pretratamientos hidrotérmicos|canola|girasol|calidad del aceite"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88110,"idioma_id":4,"titulo":"Understanding the long-term spatial dynamics of a semiarid   grass-shrub steppe through inverse parameterization for simulation models","resumen":"Desertification threatens 70% of all dry lands worldwide by diminishing the provision of economic and ecosystem services. However, since long-term vegetation dynamics of semiarid ecosystems are difficult to study, the opportunities to evaluate desertification and degradation properly are limited. In this study, we tailored, calibrated and tested a spatially-explicit simulation model (DINVEG) to describe the long-term dynamics of dominant grass and shrub species in the semiarid Patagonian steppe. We used inverse techniques to identify parameterizations that yield model outputs in agreement with detailed field data, and we performed sensitivity analyses to reveal the main drivers of long-term vegetation dynamics. Whereas many parameterizations (10\u201345%) matched single field observations (e.g. grass and shrub cover, species-specific density, aboveground net primary production [ANPP]), only a few parameterizations (0.05%) yielded simultaneous match of all field observations. Sensitivity analysis pointed to demographic constraints for shrubs and grasses in the emergence and recruitment phase, respectively, which contributed to balanced shrub-grass abundances in the long run. Vegetation dynamics of simulations that matched all field observations were characterized by a stochastic equilibrium. The soil water content in the top layer (0\u201310 cm) during the emergence period was the strongest predictor of shrub densities and population growth rates and of growth rates of grasses. Grasses controlled the shrub demography because of the resource overlap of grasses with juvenile shrubs (i.e. water content in the top layer). In agreement with field observations, ecosystem function buffered the strong variability in precipitation (a simulated CV in ANPP of 16% vs CV in precipitation of 33%). Our results show that seedling emergence and recruitment are critical processes for long-term vegetation dynamics in this steppe. The methods presented here could be widely applied when data for direct parameterization of individual-based models are lacking, but data corresponding to model outputs are available. Our modeling methodology can reduce the need for long-term data sets when answering questions regarding community dynamics.","palabras_clave":"conservación de pastizales|modelos de simulación|mosaicos de vegetacion|patrones espaciales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88111,"idioma_id":4,"titulo":"Assessing the potential of wildfires as a sustainable bioenergy opportunity","resumen":"As the environmental and economic consequences of fossil-fuel use become clear, land is increasingly targeted as a source of bioenergy. We explore the potential for generating electricity from biomass vulnerable to fires as an ecologic and socioeconomic opportunity that can reduce the risk of greenhouse gas generation from wildfires and help to create incentives to preserve natural and seminatural vegetation and prevent its conversion to agriculture, including biofuel crops. On the basis of a global analysis of the energy generation and spatial distribution of fires, we show that between 2003 and 2010, global fires consumed ~8300 ± 592 PJ yr1 of energy, equivalent to ~36?44% of the global electricity consumption in 2008 and >100% national consumption in 57 countries. Forests\/woodlands, cultivated areas, shrublands, and grasslands contributed 53%, 19%, 16%, and 3.5% of the global energy released by fires. Although many agroecological, socioeconomic, and engineering challenges need to be overcome before diverting the energy lost in fires into more useable forms, done cautiously it could reconcile habitat preservation with economic yields in natural systems.","palabras_clave":"BIOELECTRICITY|BIOMASS BURNING|DRY FORESTS|FIRE RADIATIVE ENERGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88112,"idioma_id":4,"titulo":"Ecosystem functional changes associated with land clearing in NW Argentina","resumen":"We assessed the extension of natural habitat conversion into croplands and grazing lands in subtropical  NW Argentina and its impact on two key ecosystem functional attributes. We quantified changes  in remotely sensed surrogates of aboveground net primary production (ANPP) and seasonality of carbon  gains. Both functional attributes are associated with intermediate ecosystem services sensu Fisher  et al. (2009). Deforestation was estimated based on photointerpretation of Landsat imagery. The seasonal  dynamics of the MODIS satellite Enhanced Vegetation Index (EVI) was used to calculate the EVI annual  mean as a surrogate of ANPP, and the EVI seasonal coefficient of variation as an indicator of seasonal variability  of carbon gains. The 2000?2007 period showed a high rate of land clearing: 5.9% of NW Argentina  (1,757,600 ha) was cleared for agriculture and ranching, corresponding to an annual rate of 1.15%. Dry  forests experienced the highest rate and humid forests the lowest. Though land clearing for agriculture  and ranching had relatively small impacts on total annual ANPP, once deforested, parcels significantly  became more seasonal than the natural vegetation replaced. Such increase in seasonality is associated  with a reduction of photosynthetic activity during a portion of the year (fallow). Direct consequences of  this reduction can be expected on several ecosystem services such as erosion control and water regulation,  due to greater exposure of bare soil, and biodiversity, due to the loss or decline in habitat quality and the  decrease of green biomass availability for primary consumers during fallow. Land clearing also increased  the magnitude of inter-annual differences in C gains, suggesting a greater buffer capacity against climate  fluctuations of natural vegetation compared to croplands.","palabras_clave":"CARBON GAIN DYNAMICS|DEFORESTATION|INTER-ANNUAL VARIABILITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88113,"idioma_id":4,"titulo":"Patterns and controls of above-ground net primary production in meadows of Patagonia. A remote sensing approach","resumen":"Questions: (1) Can above-ground net primary production (ANPP) of Patagonianmeadows be estimated from remote sensing? (2) How does ANPP of Patagonianmeadows change in space and time?Location: Northwestern Patagonia, meadows embedded in a steppematrix (39?43°S, 70?72ºW; area: 85 000 km2).Methods: For the first question, we contrasted field ANPP measurements withMODIS high-spatial resolution (pixel size: 0.0625 km2) data and developed amodel that estimates radiation use efficiency. For the second question, weapplied the model to a 6-year MODIS record for 14 meadows whose physiognomicheterogeneity was known frompreviouswork.Results: Up to 77%of the field-based ANPP variation was accounted for by theabsorbed photosynthetic radiation, based on a linear transformation of the normalizeddifference vegetation index derived from MODIS data. Mean radiationuse efficiency was 0.54 g dry matter MJ1. ANPP ranged between 610 and1060 g m2 year1, which represents three to 5.3 times the ANPP of the surroundingarid and semi-arid steppes. The inter-annual coefficient of variation ofANPP was 10%, which is higher than other systems of similar productivity, butmuch lower than the surrounding steppes (33%). At the level of managementunits (paddock), ANPP spatial variations were mainly related to the proportionof Prairies, a proxy for low topographic position in the landscape, and longitude,a proxy for precipitation. ANPP inter-annual variation was most related to latitude,a proxy for temperature.Conclusion: The model developed and tested can be used to infer ANPP fromremote sensing data at a spatial resolution that allows one to detect variabilitywithin meadows and management units. Variations at both the physiognomicunit and paddock level were associated with geographic patterns and topography.Meadows were three to five times more productive and less fluctuatingthan nearby steppes. When compared with other ecosystems, their productivitywas high, butmore variable inter-annually, likely due to exceptionally high variabilityof precipitation in Patagonia.","palabras_clave":"RADIATION USE EFFICIENCY|NDVI|EVI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88114,"idioma_id":5,"titulo":"Caracterización regional de la estructura y de la productividad de la vegetación de la Puna mediante el uso de imágenes MODIS","resumen":"La Puna es una región semiárida ubicada por encima de los 3300 msnm. en el noroeste argentino. Si bien existen descripciones florísticas parciales de la vegetación en el área, no existen trabajos que describan su fisonomía y su funcionamiento, aspectos claves para el manejo de la vegetación de la región. El objetivo de este trabajo fue cartografiar los diferentes tipos fisonómicos presentes y caracterizar su funcionamiento a partir de la estimación de la productividad primaria neta aérea (PPNA) en un área de 69210 km2 en las provincias de Salta y Jujuy. La aproximación metodológica combinó la utilización de datos provistos por sensores remotos, modelos biofísicos para estimar la productividad y censos fisonómico - florísticos. De las clases vegetadas, las estepas arbustivas (Estepa arbustiva densa y Estepa arbustiva rala) fueron las que ocuparon mayor proporción del territorio analizado, cubriendo entre ambas el 45% aproximadamente, mientras que las Estepas graminosas densas fueron las menos representadas, cubriendo poco más del 1%. Entre las clases no vegetadas el Suelo desnudo fue la clase más extendida, cubriendo aproximadamente 30% del área, seguida por la clase Salar, que ocupó 8.15%. El tipo fisonómico más productivo fue la Estepa graminosa densa (PPNA = 3900 kg MS\/ha.año), mientras que la Estepa arbustiva rala presentó la menor productividad (PPNA = 472 kg MS\/ha.año). Los restantes tipos fisonómicos no superaron en promedio los 1000 kg MS\/ha.año.","palabras_clave":"Indices Espectrales|Sensores Remotos|RECURSOS FORRAJEROS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88115,"idioma_id":4,"titulo":"An exploration of direct and indirect drivers of herbivore reproductive performance in arid and semi arid rangelands by means of structural equation models","resumen":"Climate variability affects both animal and plant populations. Understanding how this variability is modulated by topography, vegetation and population densities and how this impact on ungulatedemography is an important step in order to forecast consequences of alternative management scenarios or the effects of climate change.Structural equation modeling (SEMs) is a tool particularly suited to this kind of situations, and allowed us to study the direct and indirect effects of climate, topography, structural and functional aspects of vegetation and population density upon reproductive performance of Patagonian sheep &#64258;ocks, measured at paddock scale. The application of SEMs in conjunction with information criteria and related techniques for model selection, model averaging and multi-model inference revealed that despite considerable model uncertainty, those paddocks towards the East, with a greater spatial variability in July temperatures and greater primary production during fall-winter (estimated by remote sensing) showed greater lambing rates. Paddocks with higher proportion of meadows and with more intense forage consumption, were also associated with a better reproductive performance. Our results not only provide quantitative hypothesis about the controls at the landscape level of herbivore performance but also provide the basis to devise better management alternatives.","palabras_clave":"Sheep|Reproductive performance|Patagonia|Structural equation modeling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88116,"idioma_id":4,"titulo":"The ecosystem functioning dimension in conservation: Insights from remote sensing","resumen":"An important goal of conservation biology is the maintenance of ecosystem processes. Incorporating quantitative measurements of ecosystem functions into conservation practice is important given that it provides not only proxies for biodiversity patterns, but also new tools and criteria for management. In the satellite era, the translation of spectral information into ecosystem functional variables expands and complements the more traditional use of satellite imagery in conservation biology. Remote sensing scientists have generated accurate techniques to cuantify ecosystem processes and properties of key importance for conservation planning such us primary production, ecosystem carbon gains, surface temperature, albedo, evapotranspiration and precipitation use efficiency; however, these techniques are still unfamiliar to conservation biologists. In this article, we identify specific fields where a remotely-sensed characterization of ecosystem functioning may aid conservation science and practice. Such fields include the management and monitoring of species and populations of conservation concern; the assesment of ecosystem representativeness and singularity; the use of protected areas as reference sites to asses global change effects; the implementation of monitoring and warning systems to guide adaptative management; the direct evaluation of supporting ecosystem services; and the planning and monitoring of ecological restorations. The approaches presented here illustrate feasible ways to incorporate the ecosystem functioning dimension into conservation through the use of satellite-derived information.","palabras_clave":"Conservation planning|Ecosystem functioning descriptors|Ecosystem monitoring|Environmental change|Protected areas|Restoration ecology|Species-environment relationships"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88117,"idioma_id":4,"titulo":"Effects of leaf-cutting ant refuse on native plant performance under two levels of grazing intensity in the Monte Desert of Argentina","resumen":"Question: Low quantities of soil nutrients often restrict plant establishment and growth in arid lands and have been partially attributed to the scarcity of organic matter in these ecosystems. Thus, increasing the amount of soil organic matter is a key issue in attempts to restore and manage a desired plant cover, especially in arid ecosystems. Refuse dumps from leaf-cutting ants are a natural source of organic matter. However, their effects on native plant performance have received limited attention to date. We experimentally determined whether refuse dumps from lea-cutting ants&nbsp; (Acromyrmex lobicornis) can be used to enhance the germination and growth of several native plant species and analyzed the potential influence of heavy grazing on this practice.Location: Monte Desert, Neuquén Province, Argentina. Methods: We collected fruits of five plant species and two types of substrates (ant refuse dump vs. control soil) from two known paddocks with different livestock densities (high vs. low). We sowed seeds, previously weighed, of each species in both substrates from both paddocks and monitored their development. We harvested emerged seedlings, documenting their age and measured their height, weight, number of leaves, root weight and root length.Results: Seed weight was lower in the highly grazed paddock for all the plant species studied. However, seed weight did not affect germination rate. Refuse dump material increased germination rate of all plant species, especially when this substrate came from the less grazed paddock (i. e., with more nutrient content). Also, germination improved when both seeds and substrates were from the less grazed paddock. Vigor variables showed more complex results, but seedlings growing in refuse dumps tended to be more vigorous. Particularly, refuse dumps from the less grazed paddock (i.e., with more nutrient content) enhanced more seedlings vigor of smaller seeds, those from the highly grazed paddock.Conclusions: Our results demonstrated that ant refuse dumps have the ability to increase germination rate in plants and improve the performance of the most representative vegetation in the Monte Desert. Given that external refuse dumps from leaf-cutting ants are a renewable resource, very abundant and easy to collect, this substrate can be used as a free natural fertilizer in arid regions to restore and manage vegetation cover, especially in heavily grazed sites.&nbsp;","palabras_clave":"Acromyrmex lobicornis| facilitation|germination;"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88118,"idioma_id":4,"titulo":"To be or not to be faithful: flexible fidelity to foraging trails in the leaf-cutting ant Acromyrmex lobicornis","resumen":"1. Ants using trails to forage have to select between two alternative routesat bifurcations, using two, potentially con&#64258;icting, sources of information to make theirdecision: individual experience to return to a previous successful foraging site (i.e.&#64257;delity)  and  ant  traf&#64257;c.  In  the  &#64257;eld,  we  investigated  which  of  these  two  types  ofinformation individuals of the leaf-cutting ant Acromyrmex lobicornis Emery use todecide which foraging route to take.2. We measured the proportion of foraging ants returning to each trail of bifurcationsthe following day, and for 4?7 consecutive days. We then experimentally increasedant traf&#64257;c on one trail of the bifurcation by adding additional food sources to examinethe effect of increased ant traf&#64257;c on the decision that ants make.3. Binomial tests showed that for 62% of the trails, ant &#64257;delity was relatively moreimportant  than  ant  traf&#64257;c  in  deciding  which  bifurcation  to  follow,  suggesting  theimportance of previous experience.4. When information con&#64258;ict was generated by experimentally increasing ant traf&#64257;calong the trail with less foraging activity, most ants relied on ant traf&#64257;c to decide.However, in 33% of these bifurcations, ants were still faithful to their trail. Thus,there is some degree of &#64258;exibility in the decisions that A. lobicornis make to accessfood resources.5. This &#64258;exible &#64257;delity results in individual variation in the response of workers todifferent levels of ant traf&#64257;c, and allows the colony to simultaneously exploit bothestablished and recently discovered food patches, aiding ef&#64257;cient food gathering","palabras_clave":"Ant   traf&#64257;c| bifurcation| decision-making"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88119,"idioma_id":4,"titulo":"Bottom-up effects may not reach the top: the influence of ant-aphid interactions on the spread of soil disturbances through trophic chains","resumen":"Soil disturbances that increase nutrient availability may trigger bottom-up cascading effects along trophicchains. However, the strength and sign of these effects may depend on attributes of the interactingspecies. Here, we studied the effects of nutrient-rich refuse dumps of the leaf-cutting ant, Acromyrmexlobicornis, on  the  food  chain  composed  of  thistles,  aphids,  tending ants  and  aphid  natural  enemies.Using  stable  isotopes  tracers,  we  show  that  the  nitrogen  accumulated  in  refuse  dumps  propagatesupward through the studied food chain. Thistles growing on refuse dumps had greater biomass andhigher aphid density than those growing in adjacent soil. These modi&#64257;cations did not affect the structureof the tending ant assemblage, but were associated with increased ant activity. In contrast to the expec-tations under the typical bottom-up cascade effect, the increase in aphid abundance did not positivelyimpact on aphid natural enemies. This pattern may be explained by both an increased activity of tendingants, which defend aphids against their natural enemies, and the low capacity of aphid natural enemies toshow numerical or functional responses to increased aphid density. Our results illustrate how biotic inter-actions  and  the  response  capacity  of  top  predators  could  disrupt  bottom-up  cascades  triggered  bydisturbances that increase resource availability.","palabras_clave":"Acromyrmex lobicornis| biotic interactions|bottom-up cascades"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88120,"idioma_id":4,"titulo":"Foliar herbivory and its effects on plant growth in native and exotic species in the Patagonian steppe","resumen":"Studies of herbivory and its consequences on  the growth of native and exotic plants could help elu-  cidate  some  processes  involved  in  plant  invasions.  Introduced species are likely to experience reduced her-  bivory in their new range due to the absence of specialist  enemies  and,  thus,  may  have  higher  bene&#64257;ts  if  they  reduce the investment in resistance and increase  their  compensatory capacity. In order to evaluate the role of  herbivory  in  disturbed  areas  within  the  Patagonian  steppe, we quanti&#64257;ed and compared the leaf levels of  herbivory  of  four  native  and  &#64257;ve  exotic  species  and  recorded the associated insect fauna. We also performed  greenhouse experiments in which we simulated herbiv-  ory in order to evaluate the compensatory capacity of  native and exotic species under di&#64256;erent herbivory levels  that  resembled  naturally  occurring  damage.  Natural  herbivory  levels  in  the  &#64257;eld  were  similar  between  the  studied  exotic  and  native  plants.  Field  observations  con&#64257;rmed that they both shared some herbivore insects,  most of which are generalists. In the greenhouse exper-  iments, both exotic and native plants fully compensated  for herbivory. Our results suggest that the studied exotic  plants are not released from herbivory in the Patagonian  steppe  but  are  able  to  fully  compensate  for  it.  The  capacity to recover from herbivory coupled with other  potential  adaptations,  such  as  a  better  performance  under disturbance and greater competitive ability than  that of the native species, may represent some of the  mechanisms responsible for the success of plant invasion  in the Patagonian steppe.","palabras_clave":"Herbivorous insect| Leaf herbivory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88121,"idioma_id":4,"titulo":"Trash to treasure: leaf-cutting ants repair nest-mound damage by recycling refuse dump materials","resumen":"Animals adjust their behaviors in response to changing environmental conditions because the costs and benefits of such behav-  iors change as conditions change. The reuse of materials from waste (i.e., recycling) rarely occurs in social insects because it   may imply significant health risks and behavioral difficulties. However, the benefit of reusing may exceed its costs under certain   circumstances. For the first time, we document that ants ?recycle? refuse materials to repair nest-mound damage. We conducted   a series of field measurements and experiments to test the hypotheses that fluctuations in this behavior in the leaf-cutting ant   Acromyrmex lobicornis depend on 1) seasonal changes in the tendency to reject refuse (a proxy of changes in their pathogen lev-  els), and\/or 2) seasonal foraging restrictions. We 1) measured the rejection of foraging ants toward experimental refuse piles   among seasons and 2) analyzed how mound condition, temperatures of fungus chamber and soil surface, and foraging activ-  ity explained this behavior using a classification tree, a powerful recursive partitioning method. Foraging ants showed similar   rejection levels toward refuse piles in different seasons. Colonies repaired mound damage with refuse materials only during the   hottest season and when they had low foraging rates, suggesting that ants recycle their refuse by a hierarchical set of decisions   dependent  on  the  risk  of  fungal  damage  and  foraging  restrictions.  Repairing  the  mounds  is  essential  during  summer,  when   temperatures inside damaged mounds are lethal to their fungus cultures. However, these high temperatures also restrict the for-  aging activity, reducing the collection of building materials. Thus, colonies with lower foraging rates apparently use their refuse   to repair mounds because this substrate requires less searching and carrying time. The use of refuse did not affect the colony   growth rate. This illustrates how ants integrate information about food, hygienic and nest conditions through a novel and plas-  tic behavior: recycling of their discarded materials","palabras_clave":"Acromyrmex lobicornis|ants"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88122,"idioma_id":4,"titulo":"Crossover from weak to strong disorder regime in the duration of epidemics","resumen":"considering that not all individuals in the population interact in the same way. Thisheterogeneity between contacts is modeled by a continuous disorder. In our model, thedisorder represents the contact time or the closeness between individuals. We find thatthe duration time of an epidemic has a crossover with the system size, from a power-lawregime to a logarithmic regime depending on the transmissibility related to the strength ofthe disorder. Using percolation theory, we find that the duration of the epidemic scales asthe average length of the branches of the infection. Our theoretical findings, supported bysimulations, explains the crossover between the two regimes.","palabras_clave":"EPIDEMIC SPREADING|DISORDER|PERCOLATION THEORY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88123,"idioma_id":4,"titulo":"Intermittent social distancing strategy for epidemic control","resumen":"We study the critical effect of an intermittent social distancing strategy on the propagation of epidemics in adaptive complex networks. We characterize the effect of our strategy in the framework of the susceptible-infected-recovered model. In our model, based on local information, a susceptible individual interrupts the contact with an infected individual with a probability &#963; and restores it after a fixed time tb.We find that, depending on thenetwork topology, in our social distancing strategy there exists a cutoff threshold &#963;c beyond which the epidemic phase disappears. Our results are supported by a theoretical framework and extensive simulations of the model. Furthermore we show that this strategy is very efficient because it leads to a ?susceptible herd behavior? that protects a large fraction of susceptible individuals. We explain our results using percolation arguments.","palabras_clave":"EPIDEMIC SPREADING|PERCOLATION THEORY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88124,"idioma_id":4,"titulo":"Uncertainties in pion and kaon fragmentation functions","resumen":"We present a detailed assessment of uncertainties in parton-to-pion and parton-to-kaon fragmentation functions obtained in recent global QCD analyses of single-inclusive hadron production data at next-to-leading order accuracy. We use the robust Lagrange multiplier approach for determining uncertainties to validate the applicability of the simpler but approximate Hessian method. Extensive comparisons of the results obtained within both methods are presented for the individual parton-to-pion and kaon fragmentation functions. We provide Hessian eigenvector sets of pion and kaon fragmentation functions that allow one to easily propagate their uncertainties to any observable. Various applications of these sets are presented for pion and kaon production in electron-positron annihilation, lepton-nucleon scattering, and proton-proton collisions.","palabras_clave":"QCD|FRAGMENTATION FUNCTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88125,"idioma_id":4,"titulo":"Global analysis of nuclear parton distributions","resumen":"We present a new global QCD analysis of nuclear parton distribution functions and their uncertainties. In addition to the most commonly analyzed data sets for the deep-inelastic scattering of charged leptons off nuclei and Drell-Yan dilepton production, we include also measurements for neutrino-nucleus scattering and inclusive pion production in deuteron-gold collisions. The analysis is performed at next-to-leading order accuracy in perturbative QCD in a general mass variable flavor number scheme, adopting a current set of free nucleon parton distribution functions, defined accordingly, as reference. The emerging picture is one of consistency, where universal nuclear modification factors for each parton flavor reproduce the main features of all data without any significant tension among the different sets. We use the Hessian method to estimate the uncertainties of the obtained nuclear modification factors and examine critically their range of validity in view of the sparse kinematic coverage of the present data. We briefly present several applications of our nuclear parton densities in hard nuclear reactions at BNL-RHIC, CERN-LHC, and a future electron-ion collider.","palabras_clave":"QCD|NUCLEAR EFFECTS|NUCLEAR PARTON DISTRIBUTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88126,"idioma_id":4,"titulo":"QCD spin physics: Partonic spin structure of the nucleon","resumen":"We discuss some recent developments concerning the nucleon?s helicity parton distribution functions: new preliminary data from jet production at RHIC suggest for the first time a non-vanishing polarization of gluons in the nucleon. SIDIS measurements at COMPASS provide better constraints on the strange and light sea quark helicity distributions. Single-longitudinal spin asymmetries in W-boson production have been observed at RHIC and will ultimately give new insights into the light quark and anti-quark helicity structure of the nucleon.","palabras_clave":"QCD|SPIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88127,"idioma_id":4,"titulo":"Phosphite applications induce molecular modifications in potato tuber periderm and cortex that enhance resistance to pathogens","resumen":"Phosphite (Phi) compounds are salts derived from phosphorous acid. These compounds have the abilityto protect plants against different pathogens. The aim of the present research was to assess the effect ofPhi compounds on components of potato tuber periderm and cortex and to assess their effects onpathogen resistance in the postharvest stage. In a series of field experiments, potassium phosphite (KPhi)was applied to seed potato tubers and foliage. After harvest, several variables were analyzed in tubersobtained from these plants. An increase in pectin content was observed in both periderm and cortextissue in tubers originating from KPhi-treated plants. After wounding and infection with Fusarium solani,a higher amount of pectin accumulation in cortical tissues was observed in tubers following treatmentwith KPhi. The content and\/or activity of polygalacturonase and proteinase inhibitor also increased intubers from KPhi-treated plants. A new isoform of chitinase was detected in the tuber periderm oftreated plants.These results suggest that KPhi applied to seed tuber and foliage induces defense responses in tuberperiderm and cortex and that these reactions are associated with structural and biochemical changes inthese tissues.","palabras_clave":"POTATO|TUBER PERIDEM|POTASIO PHOSPHITE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88128,"idioma_id":4,"titulo":"Recombinant vaccines and infectious bursal disease virus","resumen":"nfectious bursal disease virus (IBDV) is the aetiological agent of infectious bursal disease (IBD), animmunosuppressive and highly contagious disease that affects young birds causing importanteconomic losses in the poultry industry worldwide. Currently, vaccination programmes withinactivated and live-attenuated viruses have been used to prevent IBD. However, these vaccinespresent a number of disadvantages, mainly because of their viral nature. Consequently, in the lasttwo decades, many studies have been conducted in order to replace conventional virus-basedvaccines by new, rationally designed vaccines that are safer as well as effective. In this review, wewill present a background on the disease and its causative agent, and focus on the development ofnew generation vaccines against this signi&#64257;cant poultry disease.","palabras_clave":"Infectious Bursal Disease| chicken immune response|recombinant vaccines|VP2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88129,"idioma_id":4,"titulo":"'Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities'","resumen":"Syntheses of a new class of phenyl butyraldehyde-derivedamines with in vitro trypanocide activitiesMed. Chem. Commun., 2012, Advance ArticleDOI: 10.1039\/C1MD00237FA new series of secondary and tertiary amines were prepared by reductive amination of syntheticphenyl-butyraldehydes and evaluated for their in vitro activity against Trypanosoma cruzi.María Fernanda Plano, Raquel M. Cravero, Isabel Nocito,Esteban Serra, Sergio A. Guerrero and Diego G. AriasReceived 15 Sep 2011, Accepted 12 Oct 2011First published on the web 14 Nov 2011","palabras_clave":"Trypanothione reductase|Inhition|Trypanosoma|Redox"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88130,"idioma_id":4,"titulo":"Surface proteins from Lactobacillus kefir antagonize in vitro cytotoxic effect of Clostridium difficile toxins","resumen":"In this work, the ability of S-layer proteins from kefir-isolated Lactobacillus kefir strains to antagonize the cytophatic effects of toxins from C. difficile (TcdA and TcdB) on eukaryotic cells in vitro was tested by cell detachment assay. S-layer proteins from eight different L. kefir strains were able to inhibit the damage induced by C. difficile spent culture supernatant to Vero cells. Besides, same protective effect was observed by F-actin network staining. S-layer proteins from aggregating L. kefir strains (CIDCA 83115, 8321, 8345 and 8348) showed a higher inhibitory ability than those belonging to non-aggregating ones (CIDCA 83111, 83113, JCM 5818 and ATCC 8007), suggesting that differences in the structure could be related to the ability to antagonize the effect of clostridial toxins. Similar results were obtained using purified TcdA and TcdB. Protective effect was not affected by proteases inhibitors or heat treatment, thus indicating that proteolytic activity is not involved. Only pre-incubation with specific anti-S-layer antibodies significantly reduced the inhibitory effect of S-layer proteins, suggesting that this could be attributed to a direct interaction between clostridial toxins and L. kefir S-layer protein. Interestingly, the interaction of toxins with S-layer carrying bacteria was observed by dot blot and fluorescence microscopy with specific anti-TcdA or anti-TcdB antibodies, although L. kefir cells did not show protective effects. We hypothesize that the interaction between clostridial toxins and soluble S-layer molecules is different from the interaction with S-layer on the surface of the bacteria thus leading a different ability to antagonize cytotoxic effect.   This is the first report showing the ability of S-layer proteins from kefir lactobacilli to antagonize biological effects of bacterial toxins. These results encourage further research on the role of bacterial surface molecules to the probiotic properties of L. kefir and could contribute to strain selection with potential therapeutic or prophylactic benefits towards CDAD.","palabras_clave":"S-LAYER PROTEIN|LACTOBACILLUS KEFIR|CLOSTRIDIUM DIFFICILE|BACTRIAL TOXINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88131,"idioma_id":4,"titulo":"Effect of human defensins on lactobacilli and liposomes","resumen":"Aims: to study the effect of human defensins (HBD-1 and HBD-2) on lactobacilli membranes as well as on liposomes prepared from purified bacterial lipids. Methods and Results: Lactobacillus delbrueckii subsp. bulgaricus CIDCA 331 and Lactobacillus delbrueckii subsp. lactis CIDCA 133 were grown in MRS broth for 16 h at 37ºC. After being washed, microorganisms were treated with 0.1 to 10 mg\/mL of HBD-1 and HBD-2 (30 min, 37ºC). Bacterial damage was determined by flow cytometry after propidium iodide (PI) staining. In parallel experiments, release of carboxyfluoresceine from liposomes prepared from bacterial lipids was determined fluorometrically (excitation 485\/20 nm, emission 528\/20 nm) in the presence of HBD-1, HBD-2 or Nisin. Exposure of lactobacilli to HBD-2 resulted in a significant membrane permeabilization being Lactobacillus delbrueckii subsp. bulgaricus CIDCA 331 the most susceptible strain. Liposomes prepared with lipids from strain CIDCA 133 were destabilized neither by HBD-1 nor by HBD-2 whereas liposomes derived from strain CIDCA 331 were susceptible to HBD-2 but not to HBD-1. Effect of defensins was strongly inhibited in the presence of NaCl and the activity increased in water. Conclusions: Results reported in the presented work indicate that lipid composition of bacterial membranes lead to a different interaction with cationic peptides such as defensins. Significance and Impact of the study: The results represent an advance in the understanding of the differential effect of HBDs on microorganisms. Differences in susceptibility to antimicrobial peptides could modify the fate of microorganisms after the interaction with host´s cells. ","palabras_clave":"lactobacilli|defensins|liposomes|probiotics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88132,"idioma_id":4,"titulo":"Determination of enantiomeric composition of ibuprofen in pharmaceutical formulations by partial least-squares regression of strongly overlapped chromatographic profiles","resumen":"In this report, we demonstrate how chiral liquid chromatography combined with multivariate chemometric techniques, specifically unfolded-partial least-squares regression (U-PLS), provides a powerful analytical methodology. Using U-PLS, strongly overlapped enantiomer profiles in a sample could be successfully processed and enantiomeric purity could be accurately determined without requiring baseline enantioresolution between peaks. The samples were partially enantioseparated with a permethyl-cyclodextrin chiral column under reversed-phase conditions. Signals detected with a diode-array detector within a wavelength range from 198 to 241 nm were recorded, and the data were processed by a secondorder multivariate algorithm to decrease detection limits. The R-(&#8722;)-enantiomer of ibuprofen in tablet formulation samples could be determined at the level of 0.5 mg L&#8722;1 in the presence of 99.9% of the S-(+)-enantiomorph with relative prediction error within±3%.","palabras_clave":"Química Analítica|Quimiometría"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88134,"idioma_id":4,"titulo":"COMPARISON OF THE PREDICTIVE ABILITY OF SEVERAL SECOND ORDER MULTIVARIATE METHODS IN THE SIMULTANEOUS DETERMINATION OF TWO THERAPEUTIC DRUGS IN HUMAN URINE","resumen":"The aim of this paper is to study the applicability of second-order multivariate methods inthe simultaneous determination of two therapeutic drugs in human urine samples. Thestudied drugs, irinotecan and thalidomide, are used in the treatment of malignant tumours.Irinotecan (CPT-11) is used to treat colon cancer; recent studies have shown the benefits ofusing thalidomide in combination with CPT-11 in the treatment of this disease. CPT-11 ishighly fluorescent, but the native fluorescence of thalidomide is very weak. The second18order methods assayed were parallel factor analysis (PARAFAC), unfolded partial least19squares (U-PLS) and multidimensional partial least-squares (N-PLS), both combined withthe residual bilinearization procedure (RBL). The excitation-emission matrices (EEMs) ofthe samples were recorded as analytical signal. The accuracy and precision of thealgorithms were evaluated through the root mean square error of prediction (RMSEP) andthe elliptical joint confidence region test (EJCR), obtaining better results with PARAFAC,which was successfully applied to the determination of thalidomide and CPT-11 in humanurine samples, after a previous liquid-liquid extraction with chloroform.","palabras_clave":"Quimica Analitica|Quimiometria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88135,"idioma_id":4,"titulo":"Uncovering interactions in Plackett-Burman screening designs applied to analytical systems. A Monte Carlo ant colony optimization approach","resumen":"        Screening  of relevant factors using Plackett-Burman designs is usual in analytical  chemistry. It relies on the assumption  that factor interactions are negligible; however, failure of recognizing  such interactions may lead to incorrect results. Factor associations can be revealed  by feature selection techniques such as ant colony optimization. This method has  been combined with a Monte Carlo approach, developing a new algorithm for  assessing both main and interaction terms when analyzing the influence of  experimental factors through a Plackett-Burman design of experiments. The results  for both simulated and analytically relevant experimental systems show  excellent agreement with previous approaches, highlighting the importance of  considering potential interactions when conducting a screening search. ","palabras_clave":"Quimica Analitica|Quimiometria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88136,"idioma_id":4,"titulo":"Monte Carlo simulation of Hamaker nanospheres coated with dipolar particles","resumen":"Parallel tempering Monte Carlo simulation is carried out in systems of N attractive Hamaker spheres dressed with n dipolar particles,  able to move on the surface of the spheres. Different cluster  configurations emerge for given values of the control parameters.  Energy per sphere, pair distribution functions of spheres and dipoles  as function of temperature, density, external electric field, and\/or  the angular orientation of dipoles are used to analyse the state of  aggregation of the system. As a consequence of the non-central  interaction, the model predicts complex structures like self-assembly  of spheres by a double crown of dipoles. This interesting result could  be of help in understanding some recent experiments in colloidal  science and biology.","palabras_clave":"self-assembly|nanospheres|Monte Carlo|Complex Sistem"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88137,"idioma_id":4,"titulo":"Vegetation patterns in limited resource ecosystems: a statistical mechanics model and Monte Carlo simulations","resumen":"The model considers individuals (plants) forming the living biomass as particles having an excluded area and a facilitation\/competition pair interaction that is controlled by four parameters. Two are related to the plant morphology while the others to the plant?plant interaction strength. By using the principle of maximum entropy and Monte Carlo simulations in the grand canonical ensemble, vegetation patterns and clusters are obtained thatresemble those of stressed ecosystems. The shape and size of these clusters strongly depend on potential external resources or natural environmental resources. A non-linear relation between the biomass density and the activityof the environmental resources as well as a shift in the vegetation cover are predicted. The model seems to be a powerful tool for the description of systems with limited resources.","palabras_clave":"Vegetation patterns|Monte Carlo|Stressed ecosystems|Facilitation\/competition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88138,"idioma_id":4,"titulo":"Genotyping of C. psittaci in central area of Argentina","resumen":"chlamydophila","palabras_clave":"CHLAMYDOPHILA PSITTACI|GENOTYPES|ARGENTINA|OMPA|MOLECULAT DETECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88139,"idioma_id":4,"titulo":"Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression","resumen":"              Histone  deacetylase inhibitors (HDACi) are being used as novel therapeutic approach for  leukemias and other hematological malignancies. However, their effect on immune  cells remains ill-defined as HDACi may impair immune surveillance. In this  work, we demonstrate that Trichostatin A (TSA), sodium valproate (VPA) and  sodium butyrate (NaB) inhibited IFN-g production by CD56dim and CD56bright  NK cells and NK cell-mediated cytotoxicity against K562 target cells. HDACi  promoted minor NK cell apoptosis but inhibited nuclear mobilization of NF-&#954;B  p50, which was accompanied by a robust down-regulation of NKG2D and NKp46 on  resting NK cells and of NKG2D, NKp44, NKp46 and CD25 on cytokine-activated NK  cells. Decreased CD25 expression promoted a weakened IFN-g secretion upon re-stimulation of NK cells with IL-2,  while reduced expression of NKG2D and NKp46 was accompanied by an impaired  NKG2D- and NKp46-dependent cytotoxicity. Moreover,  NK cells from normal mice treated in vivo  with TSA displayed a diminished expression of NK1.1, NKG2D and NKp46 and  secreted reduced amounts of IFN-g upon ex vivo stimulation with cytokines.  Thus, our preclinical results indicate that HDACi exert deleterious effects on  NK cell function which may weaken immune surveillance and facilitate relapse of  the malignant disease in HDACi-treated patients.","palabras_clave":"histone deacetylases|NK cells|NKG2D|NKp46"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88140,"idioma_id":4,"titulo":"Human Natural Killer Cell Maturation Defect Supports In Vivo CD56(bright) to CD56(dim) Lineage Development","resumen":"Two populations of human natural killer (NK) cells can be identified in peripheral blood. The majority are CD3(-)CD56(dim) cells while the minority exhibits a CD3(-)CD56(bright) phenotype. In vitro evidence indicates that CD56(bright) cells are precursors of CD56(dim) cells, but in vivo evidence is lacking. Here, we studied NK cells from a patient that suffered from a melanoma and opportunistic fungal infection during childhood. The patient exhibited a stable phenotype characterized by a reduction in the frequency of peripheral blood CD3(-)CD56(dim) NK cells, accompanied by an overt increase in the frequency and absolute number of CD3(-)CD56(bright) cells. These NK cells exhibited similar expression of perforin, CD57 and CD158, the major activating receptors CD16, NKp46, NKG2D, DNAM-1, and 2B4, as well as the inhibitory receptor CD94\/NKG2A, on both CD56(bright) and CD56(dim) NK cells as healthy controls. Also, both NK cell subpopulations produced IFN-&#947; upon stimulation with cytokines, and CD3(-)CD56(dim) NK cells degranulated in response to cytokines or K562 cells. However, upon stimulation with cytokines, a substantial fraction of CD56(dim) cells failed to up-regulate CD57 and CD158, showed a reduction in the percentage of CD16(+) cells, and CD56(bright) cells did not down-regulate CD62L, suggesting that CD56(dim) cells could not acquire a terminally differentiated phenotype and that CD56(bright) cells exhibit a maturation defect that might result in a potential altered migration pattern. These observations, support the notion that NK cells of this patient display a maturation\/activation defect that precludes the generation of mature NK cells at a normal rate accompanied by CD56(dim) NK cells that cannot completely acquire a terminally differentiated phenotype. Thus, our results provide evidence that support the concept that in vivo CD56(bright) NK cells differentiate into CD56(dim) NK cells, and contribute to further understand human NK cell ontogeny.","palabras_clave":"NATURAL KILLER CELLS|CD56|MATURATION|ONTOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88141,"idioma_id":4,"titulo":"Ionic Self-Assembly of Electroactive Biorecognizable Units: Electrical Contacting of Redox Glycoenzymes Made Easy","resumen":"This work explores the synergistic combination of ionic self-assembly and recognition-directed assembly for the modification of electrode surfaces with redox glycoenzymes on the basis of electroactive glycopolyelectrolyte\u2013surfactant complexes.","palabras_clave":"IONIC SELF ASSEMBLING|BIORECOGNITION|SIGNAL TRANSDUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88142,"idioma_id":5,"titulo":"Seroprevalencia de Fasciolosis en Niños del Valle de Fiambalá, Tinogasta, Argentina","resumen":"Fasciolosis is an alimentary zoonotic caused by Fasciola hepatica (unca or uncaca), a parasite that causes hepatobiliary disease with relative absence of gastrointestinal symptoms. Humans can get sick by eating plants or contaminated water. It is difficult to diagnose in the invasive stage becausethere are not eggs in feces. The need for count on diagnostic techniques with greater sensitivity and specificity is needed both for the clinic to determine endemic areas. Serological methods are useful in acute cases or as a screening test. Although fasciolosis is acquired at all ages, those most affected are children and lower of 19 ages groups have the highest rates of infection. The aim of this study was to determine the seroprevalence of fasciolosis in children and adolescents from Fiambalá Valley. There were collected serum samples from 77 children during the month of December 2009, in the town of Taton. They all agreed with their parents´written consent for evaluation. Thirty three serums were male and 44 female. Serum samples from children tested by ELISA for the detection of circulating IgG antibodies, revealed 44\/77 (51,94 %) were positive. Twenty were females and 20 males. There was no significant difference by sex. The results show that the presence of fasciolosis should be considered as a disease of public health importance. Early detection should be a priority in control programs. The percentage of Fasciola hepatica infection found shows that Fiambalá valley is an endemic area for the different pathologies and requires strong educational intervention for prevention.","palabras_clave":"FASCIOLOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88143,"idioma_id":4,"titulo":"First case report of infection caused by Encephalitozoon intestinalis in a domestic cat and a patient with AIDS","resumen":"  Microsporidia are eukaryotic, intracellular obligate parasites that infect invertebrate and vertebrate animals, and have emerged as important opportunistic parasites in AIDS patients. We used light microscopy to detect microsporidial spores in stool samples of a domestic cat confirmed as Encephalitozoon intestinalis by PCR, owned by an AIDS patient with chronic diarrhea and E. intestinalis infection. Cats can be considered hosts of E. intestinalis.","palabras_clave":"ENCEPHALITOZOON INTESTINALIS|CAT|MICROSPORIDIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88144,"idioma_id":4,"titulo":"Molecular identification of protozoa causing AIDS-associated cholangiopathy in Buenos Aires, Argentina","resumen":"Several species of microsporidia and coccidia are protozoa parasites responsible for cholangiopathy disease in patients infected with human immunodeficiency virus. The goals of this work were to identify opportunistic protozoa by molecular methods and describe the clinical manifestations at the gastrointestinal tract and the biliary system in patients with AIDS- associated cholangiopathy from Buenos Aires, Argentina. This study included 11 adult HIV-infected individuals with diagnosis of AIDS- associated cholangiopathy. An upper gastrointestinal endoscopy with biopsy specimen collection and a stool analysis for parasites were performed on each patient. The ultrasound analysis revealed bile ducts compromise and endoscopic retrograde cholangiopancreatography and a magnetic resonance cholangiography were carried out. The identification to the species level was performed on biopsy specimens by molecular methods.Microorganisms were identified in 10\/11 cases. The diagnosis in patients with sclerosing cholangitis was cryptosporidiosis in 3 cases, cystoisosporosis in one case, and microsporidiosis in one case. In patients with sclerosing cholangitis and papillary stenosis the diagnosis was microsporidiosis in 2 cases, cryptosporidiosis in 2 cases and cryptosporidiosis associated with microsporidiosis in other case. In 3 cases with cryptosporidiosis the species was Cryptosporidium hominis; one case was associated with Enterocytozoon bieneusi, while the other two were coinfected with Cryptosporidium parvum. In the 4 cases with microsporidiosis the species was E. bieneusi. These results suggest that molecular methods may be useful tools to identify emerging protozoa in patients with AIDS- associated cholangiopathy. ","palabras_clave":"CRYPTOSPORIDIUM HOMINIS|CRYPTOSPORIDIUM PARVUM|ENTEROCYTOZOON BIENEUSI|SCLEROSING CHOLANGITIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88145,"idioma_id":4,"titulo":"Analysis of trace elements in multifloral Argentine honeys and their classification according to provenance","resumen":"The concentrations of 14 trace elements Br, Ce, Co, Cr, Cs, Eu, Fe, La, Rb, Sb, Sc, Sm, Th and Zn) have been determined in 120 samples of light-coloured honeys from the provinces San Luis and La Pampa, middle Argentina, using instrumental neutronic activation analysis. The elemental composition was used in multivariate statistical analysis to discriminate the honeys according to geographical origin. Results indicated that element analysis provides a good prospect for discriminating honeys by regions, even if the element composition is not dependent on the year of harvest. Eight key variables (Ce, Cr, Cs, Fe, La, Sb, Sc and Zn) were identified by LDA as providing the maximum discrimination between samples according to their provenance. It was concluded that the methodology in its current state can be used to provide reliable origin information.","palabras_clave":"PATTERN RECOGNITION|DISCRIMINANT ANALYSIS|FINGERPRINTS|HONEY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88146,"idioma_id":4,"titulo":"Chemometric Characterization of Sunflower Seeds","resumen":"The spectroscopic characterization of different varieties of sunflower seeds based on their oleic acid content is proposed. One hundred fifty samples of sunflower seeds from different places of Argentina were analyzed by near-infrared diffuse reflectance spectroscopy (NIRDRS). Seed samples were grounded and sieved without chemical treatment previous to the analysis. For the characterization, the multivariate methods used were: principal components analysis (PCA), cluster analysis (CA), linear discriminant analysis (LDA) and partial least squares discriminant analysis (PLS-DA). By using PCA, CA and LDA, and from the point of view of varieties of sunflower seeds, two groups were differentiated, based on the concentration of oleic acid: a low oleic group, which ranged from 15% to 25 % w\/w oleic acid; and the other one (mid-high oleic varieties) which ranged from 26 to 90 % w\/w oleic acid. However, by using the PLS-DA three groups were correctly differentiated based on the concentration of oleic acid: low oleic (from 15 to 25 % w\/w oleic acid); mid oleic (26 to 76 % w\/w oleic acid) and high oleic (more than 77 % w\/w oleic acid) demonstrating the high ability of this method. This multivariate characterization of sunflower seed varieties did not require chromatographic analysis to generate the matrix of concentrations, only direct measures of NIRDRS spectra were required. This characterization can be useful to quickly know the variety of sunflower seed in the grain market.","palabras_clave":"SUNFLOWER|SEEDS|OLEIC ACID|CHEMOMETRICS|INFRARED SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88147,"idioma_id":4,"titulo":"MULTIVARIATE ANALYSIS OF MAJOR, MINOR AND TOXIC ELEMENTS IN Sechium edule","resumen":"Multivariate data analysis was performed on Sechium edule, using as variables the concentration of the follow elements: Ag, Al, As, Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, K, La, Mg, Mn, Mo, Na, Nb, Ni, P, Pb, S, Sb, Se, Sn, Sr, Ta, Te, Ti, Tl, V, Zn and Zr, analyzed by inductively coupled plasma optical emission spectrometry (ICPOES) on a total of 15 replicates Sechium fruits, including whole fruit (Fr), pulp (Pu) and seed (Se). Principal Components Analysis (PCA) was carried out, in order to find an optimal model of classification and find the most relevant variables for the analysis of the fruit (which were the concentration of Ca, Cd, Fe, Mg, P y S); after that, the same variables were used for Clusters Analysis (CA) and Linear Discriminant Analysis (LDA). Thus, it was possible to make a proper classification of the three components of the fruit: Fr, Pu and Se by the three multivariate methods. As conclusion, multivariate methods were able to classify different parts of Sechium edule.","palabras_clave":"MULTIVARIATE ANALYSIS |LDA|TOXIC ELEMENTS|Sechium edule"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88148,"idioma_id":4,"titulo":"Synthesis of a Fluorescently Labeled Compound for the Detection of Arsenic-induced Apoptotic HL60 Cells","resumen":"            Arsenic compounds have shown medical usefulness since they  proved to be effective in causing complete remission of acute promyelocytic  leukemia. In this work we obtained a fluorescently labeled arsenic compound that  can be used with current fluorescence techniques for basic and applied research,  focused on arsenic-induced apoptosis studies. This compound is an arsanilic  acid bearing a covalently linked FITC that was chemically synthesized and  characterized by fluorescence, UV-Vis, mass and FTIR spectrometry. In addition,  we assessed its apoptotic activity as well as its fluorescent labeling properties  in HL60 cell line as a leukemia cell model through flow cytometry. We obtained  a compound with a 1:1 FITC:arsenic ratio and a 595 m\/z, confirming its  structure by FTIR. This compound proved to be useful at inducing apoptosis in  the leukemia cell model and labeling this apoptotic cell population, in such a  way that the highest FITC fluorescence correlated with the highest arsenic  amount. ","palabras_clave":"APOPTOSIS|ARSANILIC ACID|ARSENIC COMPOUNDS|FLUORESCEIN|FLUORESCENCE TECHNIQUES|LEUKEMIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88149,"idioma_id":4,"titulo":"Intratracheal Instillation of Lipopolymeric Vectors and the Effect on Mice Lung Physiology","resumen":"    Background\/Aims:  The current study comparedthe effects of intratracheal administration ofdifferent  lipopolymeric vectors on lung function andhistology in normal mice. Methods:  Forty-eightBALB\/c mice were randomly divided into 8 groups(6\/group). All  animals received intratrachealinstillation of the following suspensions:  polymerized[(A) 1,2-dimyristoyl-sn-glycero-3-phosphocholine(DMPC):1,2-bis-(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine  (DC8,9PC):1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), (B)DMPC:DC8,9PC:stearylamine  (SA), (C)DMPC:DC8,9PC:myristoylcholine chloride (MCl)];nonpolymerized [(D)  DMPC:DC8,9PC:DOTAP, (E)DMPC:DC8,9PC:SA, (F) DMPC:DC8,9PC:MCl]together with  plasmid DNA; vehicle (control), andpDsRed2-N1 plasmid DNA (DNA). At 24 h, the  survivalrate, lung mechanics (resistive and viscoelasticpressure, static  elastance) and morphometry wereanalyzed. Results: The survival rate was 50% in  D, 40% in E and F, and 100% in the CTRL, DNA, A, Band C groups. Animals from  groups D, E, and F thatdied presented diffuse pulmonary hemorrhagiccapillaritis.  Lung mechanics, the fraction of normaland collapsed alveoli, as well as the  number ofpolymorphonuclear and mononuclear cells in lungtissue were similar in  all surviving mice. Conclusion:Intratracheal instillation of polymerized  particles is safecompared with nonpolymerized formulations and maybe used for  future gene\/drug therapy.","palabras_clave":"LIPOPOLYMERS|MICE|LUNG|MECHANICS|GENE THERAPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88150,"idioma_id":4,"titulo":"Structural effect of cationic amphiphiles in diacetylenic photopolymerizable membranes","resumen":"      Liposomes have  been an excellent option as drug delivery systems, since they are able of incorporating  lipophobic and\/or lipophilic drugs, reduce drug side effects, increase drug targeting,and  control delivery. Also, in the last years, their use reached the field of gene therapy,  as non-viralvectors for DNA delivery. As a strategy to increase system stability,  the use of polymerizablephospholipids have been proposed in liposomal formulations.  In this work, through differentialscanning calorimetry (DSC) and electron spin resonance  (ESR) of spin labels incorporated into thebilayers, we structurally characterize  liposomes formed by a mixture of the polymerizable lipiddiacetylenic phosphatidylcholine  1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine(DC8,9PC) and the zwitterionic  lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), in a 1:1molar ratio. It  is shown here that the polymerization efficiency of the mixture (c.a. 60%) is muchhigher  than that of pure DC8,9PC bilayers (c.a. 20%). Cationic amphiphiles (CA) were added,  in afinal molar ratio of 1:1:0.2 (DC8,9PC:DMPC:CA), to make the liposomes possible  carriers forgenetic material, due to their electrostatic interaction with negatively  charged DNA. Threeamphiphiles were tested, 1,2-dioleoyl-3-trimetylammonium-propane  (DOTAP), stearylamine (SA)and trimetyl (2-miristoyloxietyl) ammonium chloride (MCL),  and the systems were studied beforeand after UV irradiation. Interestingly, the  presence of the cationic amphiphiles increased liposomespolymerization, MCL displaying  the strongest effect. Considering the different structural effects thethree cationic  amphiphiles cause in DC8,9PC bilayers, there seem to be a correlation between thedegree  of DC8,9PC polymerization and the packing of the membrane at the temperature it  isirradiated (gel phase). Moreover, at higher temperatures, in the bilayer fluid  phase, more polymerizedmembranes are significantly more rigid. Considering that  the structure and stability of liposomes atdifferent temperatures can be crucial  for DNA binding and delivery, we expect the study presentedhere contributes to the  production of new carrier systems with potential applications in gene therapy.","palabras_clave":"POLYMERIC LIPOSOME|ESR|SPIN LABEL|DIACETYLENIC LIPID|CATIONIC AMPHIPHILE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88151,"idioma_id":4,"titulo":"The alternative Epac \/cAMP pathway and the 1 MAPK pathway mediate hCG induction of leptin in placental cells","resumen":"Leptin is the product of the obese gene, originally considered as an adipocyte-derived   signaling molecule for the central control of metabolism. However, pleiotropic effects of   leptin have been identified in reproduction and pregnancy, particularly in the placenta,   where it may work as an autocrine hormone, mediating angiogenesis, growth and   immunomodulation. In the present work, we demonstrated that recombinant human   chorionic gonadotropin (hCG) added to JEG-3 choriocarcinoma cell line or to placental   explants induces endogenous leptin expression, when analyzed by quantitative RT-PCR.   On the other hand, we found that hCG increased cAMP intracellular levels in BeWo cells in   a dose-dependent manner and stimulated cAMP response element (CRE) activity, evaluated   by transient transfection. Moreover, cotransfection with an expression plasmid of a   dominant negative mutant of CREB caused a significant inhibition of hCG stimulation of   leptin promoter activity. These results demonstrate that hCG indeed activates cAMP\/PKA   pathway, and that this pathway is involved in leptin expression. Nevertheless, we found   leptin induction by hCG is dependent on cAMP levels. Treatment with (Bu)  cAMP in   combination with low and non stimulatory hCG concentrations led to an increase in leptin   expression, whereas stimulatory concentrations showed the opposite effect. The   involvement of PKA on leptin induction by hCG was investigated. We found that specific   PKA inhibition by H89 caused a significant increase of hCG leptin induction, suggesting   that probably high cAMP levels might inhibit hCG effect. It was found that hCG   enhancement of leptin mRNA expression involved the MAPK pathway. In this work, we   demonstrated that hCG leptin induction through the MAPK signaling pathway is inhibited   by PKA. In this sense, we observed that ERK1\/2 phosphorylation increased when hCG   treatment was combined with H89. In view of these results, the involvement of the   alternative cAMP\/Epac signaling pathway in hCG dependent leptin expression was studied.   We observed that a cAMP analogue that specifically activates Epac (CPT-OMe) stimulated   leptin placental expression by hCG. In addition, the overexpression of Epac and Rap1   proteins increased leptin promoter activity and enhanced hCG effect in transient   transfection assays.   In conclusion, we provide evidence suggesting that hCG induction of leptin gene   expression in placental cells is mediated not only by activation of the MAPK signaling   pathway but also by the alternative cAMP\/Epac signaling pathway. Moreover, we have   demonstrated that PKA activation interferes with this mechanism. These data provide novel   insights into the signaling molecules and mechanisms regulating leptin gene expression in   placenta by hCG. ","palabras_clave":"LEPTIN|HCG|CAMP|PLACENTA|GENE EXPRESSION|PKA|MAPK SIGNAL TRANSDUCTION PATHWAY|EPAC\/CAMP ALTERNATIVE PATHWAY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88152,"idioma_id":4,"titulo":"cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents","resumen":"The master circadian clock in mammals is located in the hypothalamic suprachiasmatic nuclei (SCN) and is synchronized by several environmental stimuli, mainly the light-dark (LD) cycle. Light pulses in the late subjective night induce phase advances in locomotor circadian rhythms and the expression of clock genes (such as Per1-2). The mechanism responsible for light-induced phase advances involves the activation of guanylyl cyclase (GC), cGMP and its related protein kinase (PKG). Pharmacological manipulation of cGMP by phosphodiesterase (PDE) inhibition (e.g., sildenafil) increases dim light-induced circadian responses, which could reflect the ability of the cGMP-dependent pathway to directly affect the photic sensitivity of the master circadian clock within the SCN. Indeed, sildenafil is also able to increase the phase-shifting effect of saturating (1200 lux) light pulses leading to phase advances of about 9 hours, as well as in C57 a mouse strain that shows reduced phase advances. In addition, sildenafil was effective in both male and female hamsters, as well as after oral administration. Other PDE inhibitors (such as vardenafil and tadalafil) also increased light-induced phase advances of locomotor activity rhythms and accelerated reentrainment after a phase advance in the LD cycle. Pharmacological inhibition of the main downstream target of cGMP, PKG, blocked light-induced expression of Per1. Our results indicate that the cGMP-dependent pathway can directly modulate the light-induced expression of clock-genes within the SCN and the magnitude of light-induced phase advances of overt rhythms, and provide promising tools to design treatments for human circadian disruptions.","palabras_clave":"Circadian system|Sildenafil|Synchronization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88153,"idioma_id":4,"titulo":"Extrahypophyseal expression of gonadotropin subunits in pejerrey Odontesthes bonariensis and effects of high water temperatures on their expression","resumen":"It has been traditionally accepted that the gonadotropins (GtHs), follicle stimulating hormone (FSH) and  luteinizing hormone (LH), are synthesized and secreted only by the pituitary. However, the presence of  theses hormones in extrapituitary tissues has been demonstrated in mammals, and more recently also  in fish. In this study, we cloned the cDNAs and characterized the expression of FSH-b, LH-b, and glycoprotein  hormone a (GPH-a) subunits from brain and gonads of male and female pejerrey Odontesthes bonariensis  at different stages of gonadal maturation. In situ hybridization revealed that, in addition to their  classical location in pituitary cells, the three GtH transcripts were also located in the gonads. FSH-b  and GPH-a subunits were found in the cytoplasm of oogonia, previtellogenic and vitellogenic oocytes  in ovaries. LH-b expression was detected in previtellogenic and vitellogenic oocytes but not in oogonia.  In males, the three subunits were expressed in spermatogonia and to a lesser extent in spermatocytes.  Exposure of fish to high water temperatures that impair pejerrey reproduction also induced a decrease  of extrahypophyseal expression of GtH subunits.","palabras_clave":"Pejerrey extrapituitary gonadotropin|High water temperature|Gene expression|In situ hybridization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88154,"idioma_id":5,"titulo":"Antropología del trabajo y memoria de los trabajadores.","resumen":"La Revista Theomai ha seleccionado y compilado distintos trabajos presentados en la IX Reunião de Antropología do MERCOSUR realizada en la ciudad de Curitiva, Brasil. Particularmente hemos elegido las ponencias del Grupo de Trabajo titulado \u201CAntropología del trabajo y memoria de los trabajadores\u201D coordinado por Carina Balladares (UBA), Juliana Cavilha (UFRGS) y Marta Regina Cioccari (Museu Nacional-UFRJ) y cuyos comentaristas fueron José Sergio Leite Lopes, Moacir Palmeira y Hernán M. Palermo     El nombre del dossier replica el título de dicho Grupo que por sus miradas y propuestas nos permiten pensar potencialidades para abordar las distintas problemáticas en torno al trabajo y los trabajadores, y al mismo tiempo realizar nuevas preguntas a viejas respuestas y viceversa. De tal modo los debates y discusiones ocurridos en este contexto fueron una continuidad de aquellos planteados en el Congreso de la Associação Brasileira de Antropologia (ABA) realizado en Belem en el año 2010, que fuera coordinado por José Sergio Leite Lopes y Rosângela Azevedo Correa. Este ámbito representó un punto de encuentro para investigadores, tesistas, docentes, etc. preocupados por las problemáticas teóricas y empíricas sobre el mundo de los trabajadores. Hemos de resaltar que dichos investigadores lograron conformar este espacio luego de diez años de ausencia respecto de aquel otro Grupo sobre \u201CCulturas Operárias\u201D realizado en 1980 en el ABA.     Por ello los diferentes textos seleccionados en este dossier recuperan la importancia de abordar desde un enfoque socio-antropológico investigaciones que problematizan  las vinculaciones que adquiere la consolidación del poder empresarial; las disputas de poder dentro y fuera de los espacios de trabajo; las estrategias y acciones de las organizaciones sindicales; las condiciones de precarización de los trabajadores, tanto en sus contextos urbanos como rurales; la construcción de la memoria social; los conflictos de género, etc. Las ponencias seleccionadas cruzan estas problemáticas central o lateralmente. Sin embargo, en todas ellas es posible analizar como se atraviesan las relaciones de poder. Tomando a Eric Wolf, es factible encontrar en los textos cómo el poder (en algunos casos patronal-empresarial) \u201C\u2026se manifiesta en las relaciones; no solo opera dentro de escenarios y campos, sino que también organiza y dirige esos mismos escenarios, además de especificar la dirección y la distribución de los flujos de energía\u201D (Wolf, 2001: 20)","palabras_clave":"trabajo|memoria|trabajadores"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88155,"idioma_id":5,"titulo":"Función ejecutiva y uso de estrategias semánticas en niños","resumen":"El objetivo de este trabajo es analizar la utilización&nbsp; de estrategias semánticas en población infantil y el efecto del funcionamiento ejecutivo sobre la frecuencia de uso de estas estrategias. Se trabajó con&nbsp;&nbsp; una muestra de 185 niños escolarizados de escuelas de gestión privada divididos en 4 grupos en función del curso. Los niños realizaron 4 ensayos de aprendizaje analizándose la cantidad de estrategias utilizadas a lo largo de los ensayos&nbsp; así como las diferencias de ensayo a ensayo. Además, se utilizaron diferentes tareas e índices de evaluación de la función ejecutiva. En primer lugar, los resultados muestran que, en la medida que se incrementa el nivel de escolaridad, los niños tienden a implementar un número mayor de estrategias semánticas en tareas de aprendizaje y recuerdo. En segundo lugar, se realizó un&nbsp; análisis discriminado por curso de las curvas de aprendizaje de las estrategias semánticas. Se encontró que, cuando se controlan las variables de funcionamiento ejecutivo, solo se obtiene un efecto significativo para el factor ensayos, y desaparece la significación estadística&nbsp; tanto en la adquisición y uso de estrategias entre los ensayos en los distintos cursos, como en las diferencias en el total de estrategias utilizadas entre los cursos. De este modo, los resultados indican que el funcionamiento ejecutivo puede jugar un rol de importancia en el uso de estrategias de codificación de información en niños.&nbsp;","palabras_clave":"ESTRATEGIAS SEMÁNTICAS|FUNCIONES EJECUTIVAS|INFANCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88156,"idioma_id":4,"titulo":"A Middle Jurassic abelisaurid from Patagonia and the early diversification of theropod dinosaurs","resumen":"Abelisaurids are a clade of large, bizarre predatory dinosaurs, most notable for their high, short skulls andextremely reduced forelimbs. They were common in Gondwana during the Cretaceous, but exceedinglyrare in the Northern Hemisphere. The oldest definitive abelisaurids so far come from the late EarlyCretaceous of South America and Africa, and the early evolutionary history of the clade is still poorlyknown. Here, we report a new abelisaurid from the Middle Jurassic of Patagonia, Eoabelisaurus mefigen. et sp. nov., which predates the so far oldest known secure member of this lineage by more than40 Myr. The almost complete skeleton reveals the earliest evolutionary stages of the distinctive featuresof abelisaurids, such as the modification of the forelimb, which started with a reduction of the distalelements. The find underlines the explosive radiation of theropod dinosaurs in the Middle Jurassic andindicates an unexpected diversity of ceratosaurs at that time. The apparent endemism of abelisauroidsto southern Gondwana during Pangean times might be due to the presence of a large, central Gondwanandesert. This indicates that, apart from continent-scale geography, aspects such as regional geography andclimate are important to reconstruct the biogeographical history of Mesozoic vertebrates.","palabras_clave":"Dinosauria|Ceratosauria|Abelisauridae|Jurassic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88157,"idioma_id":4,"titulo":"Histopathological features of osteonecrosis of the jaw associated to biphosphonates","resumen":"CORRESPONDENCE","palabras_clave":"OSTEONECROSIS|JAW|BISPHOSPHONATES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88158,"idioma_id":4,"titulo":"Oral mucosa tissue response to titanium cover screws","resumen":"Titanium is the most widely used metal in dental implantology. The release of particles from metal structures into the biologic milieu may be the result of electrochemical processes (corrosion) and\/or mechanical disruption during insertion, abutment connection, or removal of failing implants. The aim of the present study is to evaluate tissue response of human oral mucosa adjacent to titanium cover screws. Methods: One hundred fifty-three biopsies of the supra-implant oral mucosa adjacent to the cover screw of submerged dental implants were analyzed. Histologic studies were performed to analyze epithelial and connective tissue as well as the presence of metal particles, which were identified using microchemical analysis. Langerhans cells, macrophages, and T lymphocytes were studied using immunohistochemical techniques. The surface of the cover screws was evaluated by scanning electron microscopy (SEM). Results: Forty-one percent of mucosa biopsies exhibited metal particles in different layers of the section thickness. Particle number and size varied greatly among specimens. Immunohistochemical study confirmed the presence of macrophages and T lymphocytes associated with the metal particles. Microchemical analysis revealed the presence of titanium in the particles. On SEM analysis, the surface of the screws exhibited depressions and irregularities. Conclusions: The biologic effects seen in the mucosa in contact with the cover screws might be associated with the presence of titanium or other elements, such as aluminum or vanadium. The potential long-term biologic effects of particles on soft tissues adjacent to metallic devices should be further investigated because these effects might affect the clinical outcome of the implant.","palabras_clave":"TITANIUM|ORAL|MUCOSA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88159,"idioma_id":4,"titulo":"Elastic scattering in the 6,7Li + 80Se systems","resumen":"Elastic-scattering angular distributions for the 6,7Li + 80Se systems were measured at center-of-mass energies from below to above the Coulomb barrier, 13 &lt; Ec.m. &lt; 24 MeV. The experimental elastic-scattering crosssections were analyzed within the framework of the optical model to study the energy dependence of the real and imaginary parts of the nuclear-interaction potential. The main objective was to investigate the threshold anomalyin those weakly bound systems. The behavior of the calculated potentials as a function of energy indicates that our results are qualitatively consistent with the dispersion relation. The threshold anomaly was observed in the 7Li +80Se system and for the 6Li + 80Se system a breakup threshold anomaly is apparent. An analysis of the absorptive processes, involved in the discussion of the experimental results, was performed using the phenomenological optical potentials that best fit the experimental data","palabras_clave":"NUCLEAR REACTIONS|ELASTIC SCATTERING|ANGULAR DISTRIBUTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88160,"idioma_id":4,"titulo":"The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptor","resumen":"Free fatty acids (FFAs) are non-competitive antagonists of the nicotinic acetylcholine receptor (AChR). Their site of action is supposedly located at the lipid-AChR interface. To elucidate the mechanism involved in this antagonism, we studied the effect that FFAs with a single double-bond at different positions (&#969;6, &#969;9, &#969;11 and &#969;13 cis-18:1) have on different AChR properties. Electrophysiological studies showed that only two FFAs (&#969;6 and &#969;9) reduced the duration of the channel open-state. The briefest component of the closed-time distribution remained unaltered, suggesting that &#969;6 and &#969;9 behave as allosteric blockers. Fluorescence resonance energy transfer studies indicated that all FFAs locate at the lipid-AChR interface, &#969;6 being restricted to annular sites and all others occupying non-annular sites. The perturbation of the native membrane order by FFAs was evaluated by DPH (1,6-diphenyl-1,3,5-hexatriene) and Laurdan fluorescence polarization studies, with the greatest decrease observed for &#969;9 and &#969;11. AChR conformational changes produced by FFAs present at the lipid bilayer were evaluated by fluorescence quenching studies of pyrene-labeled AChR and also using the AChR conformational-sensitive probe crystal violet. All cis-FFAs produced AChR conformational changes at the transmembrane level, but only &#969;9, &#969;11 and &#969;13 perturbed the resting state. Thus, the position and isomerism of the torsion angle of unsaturated FFAs is probably a key factor in terms of AChR blockage, suggesting that FFAs with a unique cis double bond at a superficial position inside the membrane directly inhibit AChR function by perturbing a potential conserved core structure for AChR gating at that level.","palabras_clave":"NICOTINIC ACETYLCHOLINE RECEPTOR|LIPID-PROTEIN INTERACTION|FREE FATTY ACID|FLUORESCENCE SPECTROSCOPY|ELECTROPHYSIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88161,"idioma_id":4,"titulo":"A High (Z)\/(E) Ratio Obtained During the 3-Hexyne Hydrogenation with a Catalyst Based on a Rh(I) Complex Anchored on a Carbonaceous Support","resumen":"The (Z)\/(E) ratio was analyzed for the 3-hexynesemi-hydrogenation at 275, 290 and 303 K. [RhCl(NH2(CH2)12CH3)3] pure and supported on a carbonaceousmaterial were used as catalysts. The supported complexshowed high values of conversion and selectivity, and itsbehaviour was much better than the Lindlar catalyst used asa reference.","palabras_clave":"(Z)\/(E) RATIO|3-HEXYNE PARTIAL HYDROGENATION|RHODIUM COMPLEX|CARBONACEOUS SUPPORT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88162,"idioma_id":4,"titulo":"Partial Hydrogenation of 3-Hexyne over Low-loaded Palladium Mono and Bimetallic Catalysts","resumen":"Partial hydrogenation of alkynes has industrial and academic relevance on a large scale, especially thosewith high selectivities. To increase the activity, selectivity and lifetime of low-loaded Pd monometalliccatalyst, the development of bimetallic systems has been investigated. In this work Pd mono (Pd\/A) andbimetallic catalysts (PdNi\/A and WPd\/A) supported on -alumina with low metal content are preparedand evaluated during the partial hydrogenation of 3-hexyne at mild conditions. XPS, XRD, TPR and hydrogenchemisorption techniques are used for the characterization, suggesting different kind of Pd specieson the mono and bimetallic catalysts. Furthermore, XPS results indicate the presence of electron richand electron-deficient palladium species (Pd&#305;&#8722; and Pdn+, with &#305; close to 0 and 0 &lt; n &lt; 2, respectively),electron-deficient species of nickel (Nin+, with n close to 2) and of W+ (with  &lt; 6) on the surface ofthe bimetallic systems. The Lindlar commercial catalyst, commonly used in these types of reactions isused for comparative purposes. Bimetallic catalysts showed higher activities and very similar selectivities(&gt;93%) than the monometallic system and further than the Lindlar catalyst. The rank of activity order is:WPd\/A &gt; PdNi\/A &gt; Pd\/A &gt; Lindlar.","palabras_clave":"ALKYNE|SELECTIVE HYDROGENATION|BIMETALLIC CATALYSTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88163,"idioma_id":4,"titulo":"Long-term treatment with meth-anandamide attenuates LPS-induced periodontitis in rats","resumen":"  Objective Evidence exists of the anti-inflammatory and   immunological properties of endocannabinoids in various  tissues; the aim of the present study was therefore to assess  the effect of long-term treatment with the synthetic cannabinoid  methanandamide (Meth-AEA) on the progression  of periodontitis in rats.  immunological properties of endocannabinoids in various  tissues; the aim of the present study was therefore to assess  the effect of long-term treatment with the synthetic cannabinoid  methanandamide (Meth-AEA) on the progression  of periodontitis in rats.  Evidence exists of the anti-inflammatory and   immunological properties of endocannabinoids in various  tissues; the aim of the present study was therefore to assess  the effect of long-term treatment with the synthetic cannabinoid  methanandamide (Meth-AEA) on the progression  of periodontitis in rats.  Materials and methods Periodontitis was induced by   injecting LPS (1 mg\/ml) into the gingiva around the neck  of the first upper and lower molars, and into the inter-dental  space between the first and second molars. This protocol  was repeated for 6 weeks on days 1, 3, and 5 of each week.  injecting LPS (1 mg\/ml) into the gingiva around the neck  of the first upper and lower molars, and into the inter-dental  space between the first and second molars. This protocol  was repeated for 6 weeks on days 1, 3, and 5 of each week.  Periodontitis was induced by   injecting LPS (1 mg\/ml) into the gingiva around the neck  of the first upper and lower molars, and into the inter-dental  space between the first and second molars. This protocol  was repeated for 6 weeks on days 1, 3, and 5 of each week.  Results Long-term treatment with topical Meth-AEA   (500 ng\/ml), applied daily to gingival tissue of rats induced  with periodontitis, significantly diminished the alveolar  bone loss, measured as the distance between the cementoenamel  junction and the alveolar crest, in both maxillary  and mandibular first molars, compared to rats without  treatment (P0.05). The treatment also reduced the production   of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,  of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,    (500 ng\/ml), applied daily to gingival tissue of rats induced  with periodontitis, significantly diminished the alveolar  bone loss, measured as the distance between the cementoenamel  junction and the alveolar crest, in both maxillary  and mandibular first molars, compared to rats without  treatment (P0.05). The treatment also reduced the production   of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,  of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,    Long-term treatment with topical Meth-AEA   (500 ng\/ml), applied daily to gingival tissue of rats induced  with periodontitis, significantly diminished the alveolar  bone loss, measured as the distance between the cementoenamel  junction and the alveolar crest, in both maxillary  and mandibular first molars, compared to rats without  treatment (P0.05). The treatment also reduced the production   of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,  of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,  P0.05). The treatment also reduced the production   of some biological mediators of periodontal  disease augmented by LPS, such as tumor necrosis factor  alpha (from 119.4 ± 9.9 pg\/mg protein to 75.1 ± 10.8,± 9.9 pg\/mg protein to 75.1 ± 10.8,   P0.05) and nitric oxide produced by inducible nitric   oxide synthase (from 507.7 ± 107.1 pmol\/min\/mg protein   to 163.1 ± 53.9, P0.01).  to 163.1 ± 53.9, P0.01).    oxide synthase (from 507.7 ± 107.1 pmol\/min\/mg protein   to 163.1 ± 53.9, P0.01).  to 163.1 ± 53.9, P0.01).    0.05) and nitric oxide produced by inducible nitric   oxide synthase (from 507.7 ± 107.1 pmol\/min\/mg protein   to 163.1 ± 53.9, P0.01).  to 163.1 ± 53.9, P0.01).  ± 107.1 pmol\/min\/mg protein   to 163.1 ± 53.9, P0.01).± 53.9, P0.01).   Conclusion These results demonstrate the beneficial   effects of treatment with Meth-AEA on gingival tissue of  rats with periodontitis.  effects of treatment with Meth-AEA on gingival tissue of  rats with periodontitis.  These results demonstrate the beneficial   effects of treatment with Meth-AEA on gingival tissue of  rats with periodontitis.","palabras_clave":"OXYGEN RADICALS|LIPOPOLYSACCHARIDE|BONE INJURY|TUMOR NECROSIS FACTOR|PROSTAGLANDINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88164,"idioma_id":5,"titulo":"\u2022\t\u201CEl juego infantil contemporáneo: medios de comunicación, nuevas prácticas y clasificaciones\u201D","resumen":"Pensar el juego es una tarea compleja: la supuesta espontaneidad, en muchos casos, de las  formas y contenidos que adquiere parecieran relegarlo a un lugar secundario en lo que concierne  a su posible abordaje. De allí que, como primer paso, haya que situarlo en una intersección:  la cultura, sus condicionamientos y posibilidades; la trayectoria social y educativa de quienes  juegan; y la historia en la que esa práctica se desarrolla. El objetivo del presente trabajo es  realizar un recorrido por algunas de las aproximaciones teóricas y metodológicas relevantes  para pensar el juego para, en un segundo momento, proponer una clasificación de los juegos  infantiles contemporáneos que incluye como novedad a los medios de comunicación en tanto  variable interviniente en el marco de un aporte para la discusión y reflexión sobre el juego y los  nuevos escenarios comunicativos. Pensar hoy el juego infantil no puede ser una tarea aislada  de los medios de comunicación en general y de la televisión en particular por el impacto que  ésta tiene en la vida de los más chicos. Concluimos que jugar es, también, una manera de  poner en acción y palabras los discursos cotidianos.","palabras_clave":"Juego infantil|cultura|Clasificación|medios de comunicación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88165,"idioma_id":5,"titulo":"ESTUDIO DE BIOFILMS Y BIODETERIORO DE MATERIALES DE INTERÉS PATRIMONIAL MEDIANTE DIFERENTES TÉCNICAS MICROSCÓPICAS","resumen":"Existen numerosas técnicas para el estudio de los biofilms y el biodeterioro, entre ellas las técnicas microscópicas que permiten un análisis profundo de la formación de los biofilms (comunidades microbianas complejas rodeadas por una matriz de sustancias poliméricas extracelulares- SPE) y de los cambios indeseables que los mismos pueden ocasionar (biodeterioro) sobre diferentes materiales a los cuales se adhieren irreversiblemente y desarrollan. En este trabajo se analizan la formación de biofilms y el biodeterioro que los mismos ocasionan en diferentes materiales de interés patrimonial (roca, papel, metales, etc.) utilizando diferentes técnicas microscópicas: microscopía óptica (MO); microscopía electrónica de barrido (MEB), microscopía de fuerza atómica (MFA) y microscopía confocal láser (MCL).","palabras_clave":"BIODETERIORO|BIOFILMS|MICROORGANISMOS|PATRIMONIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88166,"idioma_id":4,"titulo":"Endogenous galectin-3 controls experimental malaria in a species-specific manner","resumen":"Galectins are evolutionarily conserved glycan-binding proteins with pleiotropic roles in innate and adaptive immune responses. Galectin-3, has been implicated in several immunological processes as well as in pathogen recognition through specific binding to glycosylated receptors on the surface of host cells or microorganisms. In spite of considerable evidence supporting a role for galectin-3 in host-pathogen interactions, the relevance of this lectin in the regulation of the host defense mechanisms in vivo is poorly understood. In this study, we analyzed the impact of galectin-3 deficiency during infection with three distinct species of rodent malaria parasites, P. yoelii 17XNL, P. berghei ANKA and P. chabaudi AS. We found that galectin-3 deficiency showed a marginal effect on the course of parasitaemia during P. chabaudi infection, but did not alter the course of parasitaemia during P. berghei infection. However, lack of galectin-3 significantly reduced P. yoelii parasitaemia. This reduced parasitaemia in Lgals3-\/- mice was consistent with higher titers of anti-P. yoelii MSP119 IgG2b isotype antibodies when compared with their wild type counterparts. Our results reflect the complexity and singularity of host-pathogen interactions, indicating a species-specific role of endogenous galectin-3 in the control of parasite infections and the modulation of antibody responses.","palabras_clave":"PARASITES|MALARIA|GALECTIN-3|IMMUNOGLOBULINS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88167,"idioma_id":4,"titulo":"Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss","resumen":"Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. In previous studies, we showed that galectin-1 (Gal1), an immunoregulatory glycan-binding protein, hierarchically triggers a cascade of tolerogenic events at the mouse fetomaternal interface. Here, we show that Gal1 confers immune privilege to human trophoblast cells through the modulation of a number of regulatory mechanisms. Gal1 was mainly expressed in invasive extravillous trophoblast cells of human first trimester and term placenta in direct contact with maternal tissue. Expression of Gal1 by the human trophoblast cell line JEG-3 was primarily controlled by progesterone and pro-inflammatory cytokines and impaired T-cell responses by limiting T cell viability, suppressing the secretion of Th1-type cytokines and favoring the expansion of CD4(+)CD25(+)FoxP3(+) regulatory T (T(reg)) cells. Targeted inhibition of Gal1 expression through antibody (Ab)-mediated blockade, addition of the specific disaccharide lactose or retroviral-mediated siRNA strategies prevented these immunoregulatory effects. Consistent with a homeostatic role of endogenous Gal1, patients with recurrent pregnancy loss showed considerably lower levels of circulating Gal1 and had higher frequency of anti-Gal1 auto-Abs in their sera compared with fertile women. Thus, endogenous Gal1 confers immune privilege to human trophoblast cells by triggering a broad tolerogenic program with potential implications in threatened pregnancies.","palabras_clave":"GALECTIN-1|FETAL TOLERANCE|PREGNANCY|FETAL LOSS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88168,"idioma_id":4,"titulo":"Nurse-like cells control the activity of chronic lymphocytic leukemia B cells via galectin-1","resumen":"Chronic lymphocytic leukemia (CLL) cells are preferentiallyactivated in so-called proliferation centers frequently found inlymph nodes and bone marrow from CLL patients.1 In these\u2018privileged\u2019 sites leukemic cells establish close contact with avariety of cell types that provide long-term support for theirsurvival and progression. In addition, CLL cells favor theestablishment of immunosuppressive microenvironments byaltering the cytokine milieu.2 Galectin 1 (Gal1), an endogenousb-galactoside-binding lectin found at sites of inflammation andtumor growth, displays pro-survival activity on malignant cells asdemonstrated for CD45RA(!) primary myeloma cells.3 Moreover,it controls tumor cell proliferation and invasiveness and has keyroles in tumor-immune escape by dampening T-cell-mediatedimmunity.4 In Hodgkin lymphoma, Gal1 is overexpressed in Reed\u2013Sternberg cells, which is a predictive biomarker of diseaseprogression and is responsible for creating the Th2\/regulatoryT-cell-skewed microenvironment typical of this lymphoproliferativedisease.5 These unique characteristics of Gal1 prompted us toinvestigate its potential role in CLL biology","palabras_clave":"chronic lymphocytic leukemia|galectin-1|Nurse-like cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88169,"idioma_id":4,"titulo":"DISRUPTING GALECTIN-1 INTERACTIONS WITH N-GLYCANS SUPPRESSES HYPOXIA-DRIVEN ANGIOGENESIS AND TUMORIGENESIS IN KAPOSI'S SARCOMA","resumen":"Kaposi?s sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8(HHV-8\/KS-associated herpesvirus [KSHV]) infection, is the most common AIDS-associatedmalignancy. Clinical management of KS has proven to be challenging because of its prevalencein immunosuppressed patients and its unique vascular and infl ammatory nature thatis sustained by viral and host-derived paracrine-acting factors primarily released underhypoxic conditions. We show that interactions between the regulatory lectin galectin-1(Gal-1) and specifi c target N-glycans link tumor hypoxia to neovascularization as part ofthe pathogenesis of KS. Expression of Gal-1 is found to be a hallmark of human KS but notother vascular pathologies and is directly induced by both KSHV and hypoxia. Interestingly,hypoxia induced Gal-1 through mechanisms that are independent of hypoxia-induciblefactor (HIF) 1  and HIF-2  but involved reactive oxygen species?dependent activation ofthe transcription factor nuclear factor  B. Targeted disruption of Gal-1?N-glycan interactionseliminated hypoxia-driven angiogenesis and suppressed tumorigenesis in vivo. Therapeuticadministration of a Gal-1?specifi c neutralizing mAb attenuated abnormalangiogenesis and promoted tumor regression in mice bearing established KS tumors. Giventhe active search for HIF-independent mechanisms that serve to couple tumor hypoxia topathological angiogenesis, our fi ndings provide novel opportunities not only for treating KSpatients but also for understanding and managing a variety of solid tumors.","palabras_clave":"Angiogenesis|N-glycan|Galectin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88170,"idioma_id":4,"titulo":"Atomistic modeling of ternary additions to NiTi and quaternary additions to Ni-Ti-   Pd, Ni-Ti-Pt and Ni-Ti-Hf shape memory alloys","resumen":"The behavior of ternary and quaternary additions to NiTi shape memory alloys is investigated using a quantumapproximate method for the energetics. Ternary additions X to NiTi and quaternary additions to Ni-Ti-Pd, Ni-Ti-Pt, and Ni-Ti-Hf alloys, for X = Au, Pt, Ir, Os, Re, W, Ta,Ag, Pd, Rh, Ru, Tc, Mo, Nb, Zr, Zn, Cu, Co, Fe,Mn, V, Sc, Si, Al and Mg are considered. Bulk properties such as lattice parameter, energy of formation, and bulkmodulus of the B2 alloys are studied for variations due to the presence of one or two simultaneous additives.","palabras_clave":"Atomistic simulation|Multicomponent alloys|BFS-Method|Shape memory alloys"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88171,"idioma_id":4,"titulo":"Modeling of high entropy alloys of refractory elements","resumen":"Reverting the traditional process of developing new alloys based on one or two single elements with minorityadditions, the study of high entropy alloys (HEA) (equimolar combinations of many elements) has become a relevantand interesting new field of research due to their tendency to form solid solutions with particular properties in theabsence of intermetallic phases. Theoretical or modeling studies at the atomic level on specific HEA, describing theformation, structure, and properties of these alloys are limited due to the large number of constituents involved.In this work we focus on HEA with refractory elements showing atomistic modeling results for W-Nb-Mo-Ta andW-Nb-Mo-Ta-V HEA, for which experimental background exists. An atomistic modeling approach is applied forthe determination of the role of each element and identification of the interactions and features responsible forthe transition to the high entropy regime. Results for equimolar alloys of 4 and 5 refractory elements, for whichexperimental results exist, are shown. A straightforward algorithm is introduced to interpret the transition to thehigh entropy regime.","palabras_clave":"Alloy design|Multicomponent alloys|High entropy alloys|BFS method"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88172,"idioma_id":4,"titulo":"New membranes obtained by grafted irradiated PVDF foils","resumen":"The present work describes a new method to produce membranes of poly(Acrylicacid-Xmonomer) using the grafting procedure. PVDF foils irradiated with Ar+ beamwith energies between 30 and 150 keV were employed as substratum. Differentcombinations of monomers in water solutions were used: acrylic acid (AAc); acrylicacid - glycidyl methacrylate (AAc-GMA); acrylic acid - styrene (AAc-S), acrylic acid-N-isopropyl acrylamide (AAc-NIPAAm) and acrylic acid - N-isopropyl acrylamide -glycidyl methacrylate (AAc-NIPAAm-GMA). A large percentage of grafting results forspecific values of: ion fluence and energy, AAc and sulfuric acid concentration, anddifferent substrata PVDF polymorphous (alpha or beta). At a particular time of thegrafting process, the Poly(AAc-Xmonomer) membranes detach from the substratum andcontinue their grafting in the solution. This method is useful to produce increasedreplicated membranes of the irradiated original surface.","palabras_clave":"radiation induce graft polymerization|peroxide method|swift heavy ions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88173,"idioma_id":4,"titulo":"Myrionema strangulans (Chordariales, Phaeophyceae) epiphyte on Ulva spp. (Ulvophyceae) from Patagonian Atlantic coasts","resumen":"Abstract Fronds of Ulva spp. from Patagonian Atlanticcoasts exhibited brown spots produced by the presence ofFronds of Ulva spp. from Patagonian Atlanticcoasts exhibited brown spots produced by the presence ofMyrionema strangulans (Chordariales, Phaeophyceae). Theoccurrence of M. strangulans on Ulva spp. is widely reportedfrom several regions of the world, but there were no detailedstudies about the subject. In the present study, we describe themorphology and interactions ofM. strangulans with Ulva spp.as observed under light and electron microscopes, and wereconstruct all stages of its life cycle based upon in vitro(Chordariales, Phaeophyceae). Theoccurrence of M. strangulans on Ulva spp. is widely reportedfrom several regions of the world, but there were no detailedstudies about the subject. In the present study, we describe themorphology and interactions ofM. strangulans with Ulva spp.as observed under light and electron microscopes, and wereconstruct all stages of its life cycle based upon in vitroM. strangulans on Ulva spp. is widely reportedfrom several regions of the world, but there were no detailedstudies about the subject. In the present study, we describe themorphology and interactions ofM. strangulans with Ulva spp.as observed under light and electron microscopes, and wereconstruct all stages of its life cycle based upon in vitroM. strangulans with Ulva spp.as observed under light and electron microscopes, and wereconstruct all stages of its life cycle based upon in vitroin vitroexperiments. The prevalence of infection by M. strangulansM. strangulanswas 100%. In case of the strongest epiphytism, the host cuticleexhibited perforations, massive depigmentation, cellular disorganization,and cuticle rupture. It was possible to demonstratea purely epiphytic life strategy of the organism bytransmission electron microscopy. M. strangulans formeddiscoid thalli constituted by vegetative filaments and radiatingfrom a central zone to a peripheral zone. Transversally, thediscs were formed by two strata: a basal monostromatic and afilamentous erect stratum. From the monostromatic stratum,hyaline hairs and reproductive structures were produced. Bothplurilocular and unilocular sporangia were present. Zoidsfrom both plurilocular and unilocular sporangia were able togerminate in culture. M. strangulans exhibited a haploid?M. strangulans formeddiscoid thalli constituted by vegetative filaments and radiatingfrom a central zone to a peripheral zone. Transversally, thediscs were formed by two strata: a basal monostromatic and afilamentous erect stratum. From the monostromatic stratum,hyaline hairs and reproductive structures were produced. Bothplurilocular and unilocular sporangia were present. Zoidsfrom both plurilocular and unilocular sporangia were able togerminate in culture. M. strangulans exhibited a haploid?M. strangulans exhibited a haploid?diploid, heteromorphic life cycle with thalli with three differentmorphologies. The haploid chromosome number was 12±2 chromosomes.Keywords Epiphyte . Life cycle . Myrionema strangulans .Patagonian Atlantic coast . Ulva spp.Epiphyte . Life cycle . Myrionema strangulans .Patagonian Atlantic coast . Ulva spp.Ulva spp.","palabras_clave":"LIFE CYCLE MYRIONEMA STRANGULANS|PATAGONIAN ATLANTIC COAST|ULVA SPP."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88174,"idioma_id":4,"titulo":"Analysis of suppressor and non-suppressor FOXP3+ T cells in HIV-1-infected patients","resumen":"Recently, it was shown that peripheral blood FOXP3+CD4+ T cells are composed of three phenotypic and functionally distinct subpopulations. Two of them having in vitro suppressive effects were characterized as resting Treg cells (rTregs) and activated Treg cells (aTregs). A third subset, identified as FOXP3+ non-Tregs, does not display any suppressor activity and produce high levels of Th1 and Th17 cytokines upon stimulation. In the present study we focus on the characteristics of these three subsets of FOXP3+CD4+ T cells in untreated HIV-1-infected patients. We found that the absolute counts of rTregs, aTregs and FOXP3+ non-Tregs were reduced in HIV-1 patients compared with healthy donors. The relative frequency of rTregs and aTregs was similar in HIV-1 patients and healthy donors, while the frequency of FOXP3+ non-Tregs was significantly higher in HIV-1 patients, reaching a maximum in those patients with the lower values of CD4 counts. Contrasting with the observations made in FOXP3- CD4+ T cells, we did not find a negative correlation between the number of rTregs, aTregs or FOXP3+ non-Tregs and virus load. Studies performed with either whole PBMCs or sorted aTregs and FOXP3+ non-Tregs cells showed that these two populations of FOXP3+ T cells were highly permissive to HIV-1 infection. Upon infection, FOXP3+ non-Tregs markedly down-regulates its capacity to produce Th1 and Th17 cytokines, however, they retain the ability to produce substantial amounts of Th2 cytokines. This suggests that FOXP3+ non-Tregs might contribute to the polarization of CD4+ T cells into a Th2 profile, predictive of a poor outcome of HIV-1-infected patients.","palabras_clave":"regulatory T cells|HIV|cytokines"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88175,"idioma_id":4,"titulo":"Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina","resumen":"St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) present ecological and antigenic similarities and are responsible for serious human diseases. In addition, WNV is a significant pathogen in terms of equine health. The purpose of our study was to analyse the seroprevalence of SLEV and WNV in equine sera collected in Santa Fe Province, Argentina. The seroprevalence determined using the plaque reduction neutralisation test was 12.2% for SLEV, 16.2% for WNV and 48.6% for a combination of both viruses. These results provide evidence of the co-circulation of SLEV and WNV in equines in Santa Fe.","palabras_clave":"ST. LOUIS ENCEPHALITIS VIRUS|WEST NILE VIRUS|HORSES|PLAQUE REDUCTION NEUTRALIZATION TEST"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88176,"idioma_id":4,"titulo":"Cost-effective solar cells containing copper indium chalcogenides prepared by SILAR method","resumen":"CuInSe2 (CISe) and CuIn(Se1-xSx)2 (CISeS) thin films have been prepared using successive ionic layer adsorption and reaction method (SILAR) to produce CuSe and In2Se3, which were subsequently heated in appropriated conditions. Glass, TCO, and TCO\/TiO2 were used as substrates. A duplex layer of TiO2 had been deposited by spraypyrolysis and doctor blade. The thermal treatment leading to the formation of the chalcogenide was carried out in two different atmospheres. The first treatment was an annealing step under argon atmosphere, where CISe is obtained. The second consisted of a sulfurization process, where sulfur powder is melted and the vapor mixed into the argon flux. The morphology and composition of the annealed films were characterized by GXRD, micro-Raman spectroscopy, and SEM\/EDS. Raman spectra and EDS showed an almost complete replacement of the Se atoms by S atoms, leading to the formation of CuIn(Se1-xSx)2, with x = 0.8. Etching the films in KCN solution was necessary to dissolve residual secondary phases. Preliminary solar cell prototypes prepared with CISe and CISeS show a clear photo-response, although the photocurrent and open circuit potential are still low. This is a promising first result, showing that CuInSe2 and CuIn(Se1-xSx)2 prepared by SILAR can be used in solar cells.","palabras_clave":"CHALCOGENIDES|OPTICAL MATERIALS |SEMICONDUCTORS|THIN FILMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88177,"idioma_id":4,"titulo":"Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase:  PEGylation of lactose analogs with multiarm polyethyleneglycol","resumen":"The trans-sialidase of Trypanosoma cruzi (TcTS) catalyzes the transfer of sialic acid from host glycoconjugates to terminal b-galactopyranosides in the mucins of the parasite. During infection, the enzyme is actively shed by the parasite to the bloodstream inducing hematological alterations. Lactitol prevents cell apoptosis caused by the TcTS, although it is rapidly eliminated from the circulatory system. Linear polyethyleneglycol (PEG) conjugates of lactose analogs were prepared but their clearance from blood was still quite fast. With the aim of improving their circulating half-lives in vivo, we now synthesized covalent conjugates of eight-arm PEG. The star-shape of these conjugates allows an increase in the molecular weight together with the loading of the active sugar. Two approaches were used for PEGylation of disaccharide derivatives containing b-D-Galp as the non-reducing unit. (1) Amide formation between benzyl b-D-galactopyranosyl-(1-6)-2-amino-2-deoxy-a-D-glucopyranoside and a succinimide-activated PEG. (2) Conjugation of lactobionolactone with amino end-functionalized PEG. Two 8-arm PEG derivatives (20 and 40 kDa) were used for each sugar. Substitution of all arms was proved by (1)H nuclear magnetic resonance (NMR) spectroscopy. The bioavailability of the conjugates in mice plasma was considerably improved with respect to the 5 kDa linear PEG conjugates retaining their inhibitory properties.","palabras_clave":"INHIBITORS|MULTIARM CONJUGATES|PEGYLATION|TRANS-SIALIDASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88178,"idioma_id":4,"titulo":"Synthesis of a derivative of a-D-Glcp (1-2)-D-Galf suitable for further glycosylation and of a-D-Glcp (1-2)-D-Gal, a disaccharide fragment obtained from varianose.","resumen":"The presence of galactofuranoyl units in infectious microorganisms has prompted the study of the metabolic pathways involved in their incorporation in glycans. Although much progress has been made with respect to the biosynthesis of &#946;-D-Galf-containing glycoconjugates, the mechanisms by which &#945;-D-Galf units are incorporated remain unclear. Penicillium varians is a non-pathogenic fungus that produces varianose, a polysaccharide containing both &#945;- and &#946;-D-Galf units, which can be used as a model for biosynthetic studies on &#945;-D-Galf incorporation. Synthetic oligosaccharide fragments related to varianose are useful as potential  substrates or standards for characterization of the &#945;-galactofuranosyl transferases. In this paper we report a straightforward procedure for the synthesis of &#945;-D-Glcp(1&#8594;2)-D-Gal (1) and the use of this compound to monitor the natural disaccharide released from varianose by mild acid degradation. The synthesis, performed by the glycosylaldonolactone approach, involved a glucosylgalactofuranose derivative, suitable for the synthesis of higher oligosaccharides with an internal D-Galf.","palabras_clave":"varianose|á-D-galactofuranose|á-D-galactofuranose;glucosylgalactofuranose"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88179,"idioma_id":4,"titulo":"Compound A, a Dissociated Glucocorticoid Receptor Modulator, Inhibits T-bet (Th1) and Induces GATA-3 (Th2) Activity in Immune Cells","resumen":"Background: Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has antiinflammatoryproperties exerted by down-modulating proinflammatory gene expression. By favouring GR monomerformation, CpdA does not enhance glucocorticoid (GC) response element-driven gene expression, resulting in a reducedside effect profile as compared to GCs. Considering the importance of Th1\/Th2 balance in the final outcome of immune andinflammatory responses, we analyzed how selective GR modulation differentially regulates the activity of T-bet and GATA-3,master drivers of Th1 and Th2 differentiation, respectively.Results: Using Western analysis and reporter gene assays, we show in murine T cells that, similar to GCs, CpdA inhibits T-betactivity via a transrepressive mechanism. Different from GCs, CpdA induces GATA-3 activity by p38 MAPK-induction ofGATA-3 phosphorylation and nuclear translocation. CpdA effects are reversed by the GR antagonist RU38486, proving theinvolvement of GR in these actions. ELISA assays demonstrate that modulation of T-bet and GATA-3 impacts on cytokineproduction shown by a decrease in IFN-c and an increase in IL-5 production, respectively.Conclusions: Taken together, through their effect favoring Th2 over Th1 responses, particular dissociated GR ligands, forwhich CpdA represents a paradigm, hold potential for the application in Th1-mediated immune disorders.","palabras_clave":"GLUCOCORTICOIDES|INMUNOMODULACION|DIFERENCIACION|LINFOCITOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88180,"idioma_id":4,"titulo":"Curcumin suppresses HIF-1A synthesis and VEGFA release in pituitary adenomas.","resumen":"Curcumin (diferuloylmethane), a polyphenolic compoundderived from the spice plant Curcuma longa, displays multipleactions on solid tumours including anti-angiogenic effects.Herewe have studied in rodent and human pituitary tumour cells theinfluence of curcumin on the production of hypoxia induciblefactor 1a (HIF1A) and vascular endothelial growth factor A(VEGFA), two key components involved in tumour neovascularisationthrough angiogenesis. Curcumin dose-dependentlyinhibited basal VEGFA secretion in corticotroph AtT20 mouseand lactosomatotroph GH3 rat pituitary tumour cells as well asin all human pituitary adenoma cell cultures (nZ32) studied.Under hypoxia-mimicking conditions (CoCl2 treatment) inAtT20 and GH3 cells as well as in all human pituitary adenomacell cultures (nZ8) studied, curcumin strongly suppressed theinduction of mRNA synthesis and protein production ofHIF1A, the regulated subunit of the hypoxia-inducedtranscription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesisand secretion ofVEGFAinGH3 cellsand in all human pituitary adenoma cell cultures investigated(nZ18). Thus, curcumin may inhibit pituitary adenomaprogression not only through previously demonstrated antiproliferativeand pro-apoptotic actions but also by its suppressiveeffects on pituitary tumour neovascularisation.","palabras_clave":"pituitary|adenoma|curcumin|angiogenesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88181,"idioma_id":5,"titulo":"Potencial uso de bacterias lácticas como vehículos vacunales","resumen":"Las bacterias lácticas (BL) pertenecen a un grupo muy heterogéneo de microorganismos que, además de sus importantes propiedades tecnológicas en la producción de alimentos, pueden ofrecer efectos beneficiosos en la salud de los consumidores.Además, diferentes grupos de investigación han demostrado que estas bacterias pueden ser convertidas en «factorías celulares» para la producción de moléculas de interés tanto médico, como biotecnológico.En este trabajo, se describen las herramientas genéticas desarrolladas para la expresión de proteínas heterólogas en BL, en especial usando Lactoccocus lactis y su gran potencial de uso como vehículos vacunales. En ensayos en animales y estudios clínicos en humanos se ha demostrado que pueden utilizarse diferentes sistemas de expresión para producir proteínas heterólogas capaces de inducir respuestas inmunes favorables, y así prevenir o tratar ciertas enfermedades.Una aplicación actual, y tal vez la más prometedora, es la utilización de las BL como vehículos vivos para la entrega de antígenos, proteínas terapéuticas y ácido desoxirribonucleico (ADN). En los últimos años se ha demostrado la gran eficiencia en la inducción de la respuesta inmunológica, tanto sistémica como a nivel de mucosas utilizando L. lactis recombinantes productores de diferentes tipos de antígenos, y en algunos casos la administración de estas cepas recombinantes a nivel de mucosa ha demostrado inducción, con éxito, de respuestas inmunes sistémicas y locales.Es por eso que actualmente las BL se utilizan con éxito como portadores genéticos en el campo de vacunación por ADN.","palabras_clave":"BACTERIAS LACTICAS|VACUNAS|PLASMIDOS|IL-10"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88182,"idioma_id":4,"titulo":"Production of Fibronectin Binding Protein A at the Surface of Lactococcus lactis Increases Plasmid Transfer In Vitro and In Vivo","resumen":"Lactococci are noninvasive lactic acid bacteria frequently used as protein delivery vectors and, more recently, as DNA delivery vehicles. We previously howed that Lactococcus lactis (LL) expressing the Fibronectin-Binding Protein A of Staphylococcus aureus (LL-FnBPA+) showed higher internalization rates in vitro in Caco-2 cells than the native (wt) lactococci and were able to deliver a eukaryotic Green Fluorescent Protein (GFP) expression plasmid in 1% of human Caco-2 cells. Here, using the bovine beta-lactoglobulin (BLG), one of the major cow?s milk allergen, and GFP we characterized the potential of LL-FnBPA+ as an in vivo DNA vaccine delivery vehicle. We first showed that the invasive strain LL-FnBPA+ carrying the plasmid pValac:BLG (LL-FnBPA+ BLG) was more invasive than LL-BLG and showed the same invasivity as LL-FnBPA+. Then we demonstrated that the Caco-2 cells, co-incubated with LL-FnBPA+ BLG produced up to 30 times more BLG than the Caco-2 cells co-incubated with the non invasive LL-BLG. Using two different gene reporters, BLG and GFP, and two different methods of detection, EIA and fluorescence microscopy, we showed in vivo that: i) in order to be effective, LL-FnBPA+ required a pre-coating with Fetal Calf Serum before oral administration; ii) plasmid transfer occurred in enterocytes without regard to the strains used (invasive or not); iii) the use of LL-FnBPA+ increased the number of mice producing BLG, but not the level of BLG produced. We thus confirmed the good potential of invasive recombinant lactic acid bacteria as DNA delivery vector in vivo. ","palabras_clave":"pValac|INVASIVE BATERIA|LACTOCOCCUS LACTIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88183,"idioma_id":4,"titulo":"The length of the Staphylococcus aureus protein A polymorphic region regulates inflammation: impact on acute and chronic infection","resumen":"Staphylococcus aureus protein A (SpA) plays a critical role in the induction of inflammation. This study was aimed to determine whether the number of short sequence repeats (SSRs) present in the polymorphic region modulates the inflammatory response induced by SpA. We demonstrated that there is a dose-response effect in the activation of interferon (IFN)-&#946; signaling in airway epithelial and immune cells, depending on the number of SSRs, which leads to differences in neutrophil recruitment. We also determined that a significant proportion of isolates from patients with chronic infections such as osteomyelitis and cystic fibrosis carry fewer SSRs than do isolates from patients with acute infections or healthy carriers and that there was an inverse correlation between the number of SSRs and the length of disease course. Given the importance of IFN signaling in eradication of S. aureus, loss of SSRs may represent an advantageous mechanism to adapt to and persist in the host.","palabras_clave":"STAPHYLOCOCCUS AUREUS|INFLAMMATION|PROTEIN A|CHRONIC INFECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88184,"idioma_id":4,"titulo":"Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells. Involvement of pregnane X-receptor","resumen":"Background      Benznidazole   (BZL) is the only antichagasic drug available in most endemic   countries. Its effect on the expression and activity of   drug-metabolizing and transporter proteins has not been studied yet.        Methodology\/Principal Findings      Expression   and activity of P-glycoprotein (P-gp), Multidrug resistance-associated   protein 2 (MRP2), Cytochrome P450 3A4 (CYP3A4), and Glutathione   S-transferase (GST) were evaluated in HepG2 cells after treatment with   BZL. Expression was estimated by immunoblotting and real time PCR. P-gp   and MRP2 activities were estimated using model substrates rhodamine 123   and dinitrophenyl-S-glutathione (DNP-SG), respectively. CYP3A4 and GST   activities were evaluated through their abilities to convert   proluciferin into luciferin and 1-chloro-2,4-dinitrobenzene into DNP-SG,   respectively. BZL (200 µM) increased the expression (protein and mRNA)   of P-gp, MRP2, CYP3A4, and GST&#960; class. A concomitant enhancement of   activity was observed for all these proteins, except for CYP3A4, which   exhibited a decreased activity. To elucidate if pregnane X receptor   (PXR) mediates BZL response, its expression was knocked down with a   specific siRNA. In this condition, the effect of BZL on P-gp, MRP2,   CYP3A4, and GST&#960; protein up-regulation was completely abolished.   Consistent with this, BZL was able to activate PXR, as detected by   reporter gene assay. Additional studies, using transporter inhibitors   and P-gp-knock down cells, demonstrated that P-gp is involved in BZL   extrusion. Pre-treatment of HepG2 cells with BZL increased its own   efflux, as a consequence of P-gp up-regulation.        Conclusions\/Significance      Modifications   in the activity of biotransformation and transport systems by BZL may   alter the pharmacokinetics and efficiency of drugs that are substrates   of these systems, including BZL itself.    ","palabras_clave":"beznidazol|HepG2|siRNA|PXR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88185,"idioma_id":4,"titulo":"A naturally occurring hypoallergenic variant of vespid Antigen 5 from Polybia scutellaris venom as a candidate for allergen-specific immunotherapy","resumen":"Stings by insects from the Hymenoptera order are known to cause life-threatening allergic reactions and impair life quality.Despite the effectiveness of conventional vespid venom immunotherapy, more standardized and safer allergy vaccines arerequired and recombinant hypoallergenic variants are important clinical tools. Antigen 5 is a major allergen of vespidvenoms and it was previously reported that Antigen 5 from Polybia scutellaris (Poly s 5) could be a hypoallergenic variant. Inthis work we assess the immunological behavior and allergenic activity of Poly s 5 in order to explore its suitability forspecific immunotherapy. With this aim, recombinant Poly s 5 was expressed in Pichia pastoris and the presence of crossreactiveepitopes with Pol a 5, a known allergenic Antigen 5, was investigated both at the IgG and IgE levels, by ELISA assaysand a basophil-mediator release assay respectively. A molecular model was also built to better understand the relationshipbetween immunological and structural aspects. In mice, Poly s 5 induced IgG antibodies which cross-reacted with Pol a 5.However, Poly s 5 induced only minimal amounts of IgE and was a poor inducer of basophil-mediator release, even whenthe cells were sensitized with Pol a 5-specific IgE. Moreover, Poly s 5-specific serum showed a specific protective activity andwas able to inhibit the Pol a 5-induced basophil degranulation. Structural analysis from the molecular model revealed that afew amino acid substitutions in the N-terminal region of Poly s 5 should lead to an alteration of the surface topography andelectrostatic potential of the epitopes which could be responsible for its hypoallergenic behavior. These findings, taken as awhole, show that Poly s 5 is likely a naturally occurring hypoallergenic Antigen 5 variant.","palabras_clave":"Vespid Antigen|Hypoallergenic Variant|Allergen-Specific Immunotherapy|Polybia scutellaris Venom"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88186,"idioma_id":4,"titulo":"Disentangling evolutionary signals: conservation, specificity determining positions and coevolution. Implication for catalytic residue prediction","resumen":"BackgroundA large panel of methods exists aiming at identifying residues with critical impact on proteinfunction based on evolutionary signals, sequence and structure information. However, it isnot clear to what extent the different methods overlap, and if any of the methods have higherpredictive potential compared to others when it comes to, in particular, the identification ofcatalytic residues (CR) in proteins.Using a large set of enzymatic protein families and measures based on different evolutionarysignals, we here sought to break up the different components of the information contentwithin a multiple sequence alignment to investigate their predictive potential and degree ofoverlap.ResultsOur results demonstrate that the different methods included in the benchmark in general canbe divided into three groups with a limited mutual overlap. One group containing real-valueEvolutionary Trace (rvET) methods and conservation, other containing mutual information(MI) methods, and the last containing methods designed explicitly for the identification ofspecificity determining positions (SDPs): integer-value Evolutionary Trace (ivET), SDPfox,and XDET. In terms of prediction of CR, we find using a proximity score integratingstructural information (as the sum of the scores of residues located within a given distance ofthe residue in question) that only the methods from the first two groups displayed a reliableperformance.Next, we investigated to what degree proximity scores for conservation, rvET and cumulativeMI (cMI) provide complementary information capable of improving the performance for CRidentification. We found that integrating conservation with proximity scores for rvET andcMI achieved the highest performance. The proximity conservation score contained nocomplementary information when integrated with proximity rvET. Moreover, the signal fromrvET provided only a limited gain in predictive performance when integrated with mutualinformation and conservation proximity scores. Combined, these observations demonstratethat the rvET and cMI scores add complementary information to the prediction system.ConclusionsThis work contributes to the understanding of the different signals of evolution and alsoshows that it is possible to improve the detection of catalytic residues by integrating structuraland higher order sequence evolutionary information with sequence conservation.","palabras_clave":"SPECIFICITY DETERMINING POSITIONS|COEVOLUTION|CATALYTIC RESIDUE|MUTUAL INFORMATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88187,"idioma_id":4,"titulo":"Sequence evolution of the intrinsically disordered and globular domains of a model viral oncoprotein","resumen":"In the present work, we have used the papillomavirus E7 oncoprotein to pursue structure-function and evolutionary studiesthat take into account intrinsic disorder and the conformational diversity of globular domains. The intrinsically disordered(E7N) and globular (E7C) domains of E7 show similar degrees of conservation and co-evolution. We found that E7N can bedescribed in terms of conserved and coevolving linear motifs separated by variable linkers, while sequence evolution of E7Cis compatible with the known homodimeric structure yet suggests other activities for the domain. Within E7N, inter-residuerelationships such as residue co-evolution and restricted intermotif distances map functional coupling and co-occurrence oflinear motifs that evolve in a coordinate manner. Within E7C, additional cysteine residues proximal to the zinc-binding sitemay allow redox regulation of E7 function. Moreover, we describe a conserved binding site for disordered domains on thesurface of E7C and suggest a putative target linear motif. Both homodimerization and peptide binding activities of E7C arealso present in the distantly related host PHD domains, showing that these two proteins share not only structural homologybut also functional similarities, and strengthening the view that they evolved from a common ancestor. Finally, we integratethe multiple activities and conformations of E7 into a hierarchy of structure-function relationships.","palabras_clave":"oncoprotein|sequence evolution|intrinsically desordered"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88188,"idioma_id":4,"titulo":"Angiotensin AT1 Receptor Inhibition- Induced Apoptosis by RhoA GTPase activation and pERK1\/2 signaling pathways in neonatal obstructive nephropathy.","resumen":"Intrarenal renin-angiotensin system (RAS) activity is increased during early development and is further enhanced by unilateral ureteral obstruction (UUO). We studied the involvement of mitogen-activated protein (MAP) kinase members, and the RhoA GTPase signaling pathways on the regulation of renal cell response after AT1 Angiotensin II receptor inhibition in obstruction Neonatal rats subjected to sham operation or complete UUO within the first 48 hours of life received saline vehicle, Losartan (AT1 inhibitor), or PD-123319 (AT2 inhibitor) during the first 14 days of life. Cortex tubular epithelial cell apoptotic response was shown by TUNEL and confirmed by electron microscopy associated with mitochondrial signaling pathway through the increased proapoptotic ratio Bax\/BcL-2 and, consequently increased caspase 3 expression and activity in obstructed kidney before and after Type 1 (AT1) receptor blockade. Non injury of contralatertal kidney was shown. The convergence of two independent signal pathways the RhoA GTPase and pERK and concurrent inhibition of JNK MAP kinase were required for the apoptotic response in 14 day kidney obstructed tubular cells either with and without losartan treatment Absence of increased AT2 protein expression after AT1 receptor inhibition on day 14 of obstruction was shown. Selective angiotensinAT2-receptor inhibition with PD-123319 had no protective effect on the renal response to complete 14 day UUO. We suggest a role of both , Rho A GTPase activation and the opposing actions of the ERK and JNK-p38 MAP kinase signaling pathways as events involved in tubular cell apoptosis regulation after AT1 receptor inhibition in neonatal UUO. ","palabras_clave":"Angiotensin AT1 receptor|APOPTOSIS|MAPKinase|RHOA|UUO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88189,"idioma_id":4,"titulo":"Caveolin-1?eNOS\/Hsp70 interactions mediate rosuvastatin antifibrotic effects 3 in neonatal obstructive nephropathy","resumen":"Evidence suggesting that statins may contribute to renoprotection has been provided in experimental and clinical studies. Statins restore endothelial nitric oxide (NO) levels by mechanisms including up-regulation of endothelial NO synthase (eNOS) expression. Caveolin-1\/eNOS interaction is essential preventing inadequate NO levels. Here, we evaluated whether caveolin-1 associated with eNOS\/Hsp70 expression may be involved in the mechanism by which rosuvastatin exerts tubulointerstitial fibrosis protection in neonatal unilateral ureteral obstruction (UUO). Neonatal rats subjected to UUO within two days of birth and controls were treated daily with vehicle or rosuvastatin (10 mg\/kg\/day) by oral gavage for 14 days. After UUO, morphometric evaluation of interstitial fibrosis&nbsp; showed increased interstitial volume (Vv) associated with reduced NO availability, increased mRNA and protein caveolin-1 expression as well as downregulation eNOS and heat shock protein 70 (Hsp70) expression. Conversely, rosuvastatin treatment attenuated the fibrotic response linked to high NO availability, decreased mRNA and protein caveolin-1 expression, and marked upregulation of eNOS and Hsp70 expression at transcriptional and posttranscriptional levels. Moreover, protein-protein interactions, determined by immunoprecipitation have shown decreased caveolin-1\/eNOS as well as increased Hsp70\/eNOS interaction, after rosuvastatin treatment. A dose dependent effect of rosuvastatin on decreased caveolin-1 expression was shown in control cortex. In conclusion, our data suggest that statins contribute to the protection against tubulointerstitial fibrosis injury in neonatal early kidney obstruction by increased NO availability, involving interaction of upregulated eNOS\/Hsp70 and downregulated caveolin-1. A role of caveolin-1 as a potential biomarker of renal fibrosis during neonatal obstructive nephropathy could be suggested. ","palabras_clave":"CAVEOLIN-1|FIBROSIS|ROSUVASTATIN|eNOS|Hsp70"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88190,"idioma_id":4,"titulo":"ROLE OF MITOCHONDRIA IN PARICALCITOL-MEDIATED CYTOPROTECTION DURING OBSTRUCTIVE NEPHROPATHY","resumen":"Vitamin D slows the progression of chronic kidney disease. Furthermore, activators of vitamin D receptors (VDR) have suppressant effects on the renin-angiotensin system, as well as anti-inflammatory and antifibrotic actions. This study aimed to evaluate the cytoprotective effects of paricalcitol, a VDR activator, at the mitochondrial level using an obstructive nephropathy model [unilateral ureteral obstruction (UUO)]. Rats subjected to UUO and controls were treated daily with vehicle or paricalcitol. The control group underwent a sham surgery. The treatment was done for 15 days (30 ng\/kg). The following were determined: biochemical parameters; fibrosis; apoptosis; mitochondrial morphology; VDR, AT(1) receptor, and NADPH oxidase 4 expression; and NADPH oxidase activity (in total and in mitochondrial fractions from the renal cortex). VDR activation prevented fibrosis (20 ± 5 vs. 60 ± 10%) and the number of TUNEL-positive apoptotic cells (10 ± 3 vs. 25 ± 4) in UUO. Biochemical, histological, and molecular studies suggest mitochondrial injury. Electron microscopy revealed in UUO electronically luminous material in the nucleus. Some mitochondria were increased in size and contained dilated crests and larger than normal spaces in their interiors. These changes were not present with paricalcitol treatment. Additionally, high AT(1)-receptor mRNA and NADPH activity was reverted in mitochondrial fractions from obstructed paricalcitol-treated animals (0.58 ± 0.06 vs. 0.95 ± 0.05 relative densitometry units and 9,000 ± 800 vs. 15,000 ± 1,000 relative fluorescence units·&#956;g protein(-1)·min(-1), respectively). These changes were consistent with an improvement in VDR expression (0.75 ± 0.05 vs. 0.35 ± 0.04 relative densitometry units). These results suggest that paricalcitol confers a protective effect and reveal, as well, a possible AT(1) receptor-dependent protective effect that occurs at the mitochondrial level.","palabras_clave":"OBSTRUCTIVE NEPHROPHATY|VITAMIN D RECEPTOR|PARICALCITOL|MITOCHONDRIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88191,"idioma_id":4,"titulo":"Apoptosis modulated by oxidative stress and inflammation during obstructive nephropathy","resumen":"Kidney apoptosis and fibrosis are an inevitable outcome of all kinds of progressive chronic kidney disease where congenital obstructive nephropathy is the primary cause of end-stage renal disease in children, and is also a major cause of renal failure in adults. The injured tubular cells linked to interstitial macrophages, and myofibroblasts produce cytokines and growth factors that promote an inflammatory state in the kidney, induce tubular cell apoptosis, and facilitate the accumulation of extracellular matrix. Angiotensin II plays a central role in the renal fibrogenesis at a very early stage leading to a rapid progression in chronic kidney disease. The increasing levels of angiotensin II induce pro-inflammatory cytokines, NF-êB activation, adhesion molecules, chemokines, growth factors, and oxidative stress. Furthermore, growing evidences report that angiotensin II (a pro-inflammatory hormone) increases mitochondrial oxidative stress regulating apoptosis induction. In addition, direct and indirect renin-angiotensin system blockade produce similar changes on these oxidative inflammatory disorders. Finally, this review summarizes our understanding about possible mechanisms that contribute with apoptosis modulated by inflammation and\/or oxidative stress during obstructive nephropathy. The new concept of anti-inflammatory tools regulating mitochondrial oxidative stress will directly affect the inflammatory process and apoptosis. This idea could have attractive consequences in the treatment of renal and other inflammatory pathologies.","palabras_clave":"OBSTRUCTIVE NEPHROPATHY|APOPTOSIS|ANGIOTENSIN II|OXIDATIVE STRESS|MITOCHONDRIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88192,"idioma_id":4,"titulo":"CLA prevents alterations in glycolytic metabolites induced by a high fat diet","resumen":"CLA has been reported to have beneficial and controversial effects on glucose and lipid metabolism. Besides, high fat (HF) diets induce alterations in liver and muscle lipid deposition, which could be associated with anomalous glucose utilization. Therefore, our aim was to evaluate whether the intake of CLA could prevent alterations in glycolytic intermediate metabolites and glycogen deposition induced by aHF diet. For this purpose, growing mice were fed a control diet (7% corn oil), aHF diet (20% corn oil), or a HF diet containing 17% corn oil þ 3% CLA for 30 days. Liver and muscle glucose intermediate metabolites and glycogen were assessed. Liver glycolysis was inhibited by HF, reflected by a decreased flow of substrates through phosphofructokinase-1a linked to elevated citrate. CLA at HF diet prevented these alterations while increasing the lactate and glycogen synthesis. In the muscle, the HF diet emphasized the reduction of the flux through phosphofructokinase-1a, without additional changes in total glycogen levels. In conclusion, dietary CLA partially prevented glycolytic pathway alterations in the liver but not in the muscle of mice fed a HF diet, associated with adverse effects as sustainedhyperglycemia and hepatic lactate accumulation.Practical applications: The present study evaluates the potential use of CLA and its consequences on several aspects of glucose metabolism. Considering that the FDA has recently approved CLA as a Generally Recognized as Safe (GRAS) category, a measure that will foster the commercial production of food and beverages with CLA supplementation, we believe it is relevant to study its potential functional properties on glucose metabolism in an experimental animal model characterized by alterations in liver and muscle lipid deposition.","palabras_clave":"CLA|GLUCOSE METABOLISM|GLYCOGEN|HIGH FAT DIET"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88193,"idioma_id":4,"titulo":"Photophysics of polyaniline: Sequence-length distribution dependence of photoluminescence quenching as studied by fluorescence measurements and Monte Carlo simulations","resumen":"The dependence  of the fluorescence quenching of electropolymerized poly(aniline-co-m-chloroaniline)    with polymer composition has been investigated. Fluorescence emission   in  polyaniline is quenched when the polymer is oxidized (brought to   emeraldine  state); the copolymers exhibit decreasing quenching as   chloroaniline contents  increases. Quenching shows a strong decrease in   the presence of 0.1 % m-chloroaniline  monomers in the feed. The   presence of dichloroaniline units in the copolymer  was confirmed by XPS   measurements and a terpolymerization reaction scheme was  developed,   obtaining the kinetic parameters. By Monte   Carlo simulation the   sequence length distributions for different  compositions were obtained   and compared; it was found that quenching, for low  aniline contents,   requires aniline sequences of at least three units. The  strong decrease   in quenching at low m-chloroaniline contents is  attributed to a   double effect: breaking of conjugation in the emeraldine form  by the   presence of the chlorinated unit, and a disruption of the close chain    packing in the crystalline domains, preventing state delocalization and   thus  efficient quenching. ","palabras_clave":"Conducting polymers|Terpolymerization|Microstructure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88194,"idioma_id":4,"titulo":"Micrometric periodic assembly of magnetotactic bacteria and magnetic nanoparticles using audio tapes","resumen":"We report micrometric periodic assembly of live and dead magnetotactic bacteria, Magnetospirillum  magneticum AMB-1, which synthesize chains of magnetic nanoparticles inside their bodies, and of  superparamagnetic Fe3O4 and ferromagnetic CoFe2O4 nanoparticles in aqueous suspensions using  periodically magnetized audio tapes. The distribution of the stray magnetic field at the surface of the  tapes was determined analytically and experimentally by magneto-optic imaging. Calculations  showed that the magnetic field close to the tape surface was of the order of 100mT, and the magnetic  field gradient was larger than 1 T mm1. Drops of aqueous solutions were deposited on the tapes,  and bacteria and particles were trapped at locations where magnetic energy is minimized, as  observed using conventional optical microscopy. Suspensions of M. magneticum AMB-1 treated  with formaldehyde and kanamycin were studied, and patterns of trapped dead bacteria indicated that  magnetic forces dominate over self-propelling forces in these experiments, in accordance with  calculated values. The behavior of the different types of samples is discussed","palabras_clave":"NANOPARTICLES|BACTERIAS|MAGNETOTACTICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88195,"idioma_id":4,"titulo":"Anisotropy and relaxation processes of uniaxially oriented CoFe2O4 nanoparticles dispersed in PDMS","resumen":"When a uniaxial magnetic field is applied to a non-magnetic dispersive medium filled with magnetic nanoparticles, they auto-assemble into thin needles parallel to the field direction, due to the strong dipolar interaction among them. We have prepared in this way magnetically oriented nanocomposites of nanometer-size CoFe2O4 particles in a polydimethylsiloxane polymer matrix, with 10% w\/w of magnetic particles. We present the characteristic magnetic relaxation curves measured after the application of a magnetic field forming an angle alpha with respect to the needle direction. We show that the magnetic viscosity (calculated from the logarithmic relaxation curves) as a function of alpha presents a minimum at alpha = 0, indicating slower relaxation processes associated with this configuration of fields. The results seems to point out that the local magnetic anisotropy of the nanoparticles is oriented along the needles, resulting in the macroscopic magnetic anisotropy observed in our measurements.","palabras_clave":"MAGNETIC ANISOTROPY|MAGNETOELASTOMERS|RELAXATION|MAGNETIC VISCOSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88196,"idioma_id":4,"titulo":"Anisotropic Magnetoresistance and Piezoresistivity in Structured Fe3O4 -Silver Particles in PDMS Elastomers at Room Temperature","resumen":"Magnetorheological elastomers, MREs, based on elastic organic matrices displaying anisotropic magnetoresistance and  piezoresistivity at room temperature were prepared and characterized. These materials are dispersions of superparamagnetic magnetite  forming cores of aggregated nanoparticles inside silver microparticles that are dispersed in an elastomeric polymer  (poly(dimethylsiloxane), PDMS), curing the polymer in the presence of a uniform magnetic field. In this way, the elastic material  becomes structured as the application of the field induces the formation of filaments of silver-covered inorganic material agglomerates  (needles) aligned in the direction of the field (parallel to the field). Because the magnetic particles are covered with silver, the MREs are  not only magnetic but also electrical conductors. The structuration induces elastic, magnetic, and electrical anisotropic properties. For  example, with a low concentration of particles in the elastic matrix (5% w\/w) it is possible to obtain resistances of a few ohms when  measured parallel to the needles or several megaohms in the perpendicular direction. Magnetite nanoparticles (Fe3O4 NP) were  synthesized by the coprecipitation method, and then agglomerations of these NPs were covered with Ag. The average size of the  obtained magnetite NPs was about 13 nm, and the magnetite-silver particles, referred to as Fe3O4@Ag, form micrometric aggregates  (1.3 &#956;m).Nanoparticles, microparticles, and theMREs were characterized by XRD, TEM, SEM, EDS, diffuse reflectance, voltammetry,  VSM, and SQUID. At room temperature, the synthesized magnetite and Fe3O4@Ag particles are in a superparamagnetic state (TB =  205 and 179 K at 0.01 T as determined by SQUID). The elastic properties and Young?s modulus of the MREs were measured as a  function of the orientation using a texture analysis device. The magnetic anisotropy in the MRE composite was investigated by FMR.  The electrical conductivity of the MRE (&#963;) increases exponentially when a pressure, P, is applied, and the magnitude of the change  strongly depends on what direction P is exerted (anisotropic piezoresistivity). In addition, at a fixed pressure, &#963; increases exponentially  in the presence of an external magnetic field (H) only when the field H is applied in the collinear direction with respect to the electrical  flux, J. Excellent fits of the experimental data &#963; versus H and P were achieved using a model that considers the intergrain electron  transport where an H-dependent barrier was considered in addition to the intrinsic intergrain resistance in a percolation process. The  H-dependent barrier decreases with the applied field, which is attributed to the increasing match of spin-polarization in the silver covers  between grains. The effect is anisotropic (i.e., the sensitivity of the magnetoresistive effect is dependent on the relative orientation  between H and the current flow J). In the case of Fe3O4@Ag, when H and J are parallel to the needles in the PDMS matrix, we obtain  changes in &#963; up to 50% for fields of 400 mT and with resistances on the order of 1&#8722;10 &#937;. Magnetoresistive and magnetoelastic  properties make these materials very interesting for applications in flexible electronics, electronic skins, anisotropic pressure, and  magnetic field sensors.","palabras_clave":"MAGNETORESISTANCE|MAGNETOELASTOMERS|PIEZORESISTIVITY|NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88197,"idioma_id":4,"titulo":"Avoidance of feeding opportunities by the whelk Buccinanops globulosum in the presence of damaged conspecifics","resumen":"Feeding decisions under predation risk can be  key in the life of scavenger organisms and tuned recognition of predation alarm  cues and flexibility in the response are fundamental. The effect of injured  conspecifics on the response behavior of the whelk Buccinanops globulosum to feeding opportunities was experimentally evaluated  in a Patagonian Bay (40° 45´ S, 64°56´ W, Argentina) in September 2010. The  effect of sex, size, body condition, or starvation on anti-predatory behavior  was assessed. The number of B. globulosum  feeding on carrion was reduced by half when damaged conspecifics were present. Smaller,  lighter, and starved individuals responded less to the presence of damaged  conspecifics. These results indicate that, under natural conditions, feeding  avoidance after detecting damaged conspecifics is a common and important anti-predatory  strategy of B. globulosum and show  that morphology and starvation are significant factors in the context of the  trade-off between feeding and avoiding predation risk.","palabras_clave":"ANTI-PREDATOR STRATEGIES|SCAVENGERS|STARVATION|NASSARIIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88198,"idioma_id":4,"titulo":"The effects of submergence on anatomical, morphological and biomass allocation responses of tropical grasses Chloris gayana and Panicum coloratum at seedling stage","resumen":"Submergence is a major factor affecting seedling recruitment in lowland grassland ecosystems. Our aim was to evaluate the tolerance to increasing flooding intensity of the seedlings of tropical grasses Chloris gayana K. and Panicum coloratum L., whose use as a forage species is increasing in humid grasslands. For this purpose, two-week old seedlings of C. gayana and P. coloratum were subjected to control, partial submergence (PS) and complete submergence (CS) in clear water for 14 days and allowed to grow for a subsequent 12 days period to assess their recovery. The following responses were assessed: generation of root aerenchyma, morphological changes and emergence from water, biomass allocation in relation to plant size, and biomass accumulation. Results showed that constitutive root aerenchyma was high in both species. Under PS and CS, root aerenchyma increased by up to 50-55% in C. gayana and up to 40-48% in P. coloratum. Under PS, the increase in seedling height for both species was the same as for controls. Under CS, C. gayana further increased its height and emerged more quickly from water; P. coloratum was not able to increase its height, and therefore the seedlings always remained underwater. The escape-from-water response of C. gayana was associated with preferential biomass allocation towards shoots and with a marked lengthening of leaf blades. By contrast, there was no change in allocation in P. coloratum, and its leaves were shorter under CS. The final biomass of C. gayana under CS was similar to that under PS, and equivalent to 54% of its controls. In P. coloratum, biomass under PS and CS were 64% and 21% of its controls (respectively), which indicates that injury caused by CS persisted during the post-submergence period. In conclusion, both species are tolerant to partial submergence at the seedling stage. However, when flood depth increases by submerging the seedlings, C. gayana is able to escape from water while P. coloratum is not, thus strongly affecting its recovery. Therefore, C. gayana appears to be a more promising species for cultivation in lowland grasslands prone to flooding of unpredictable intensity.","palabras_clave":"allometry|Chloris gayana|Panicum coloratum|submergence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88199,"idioma_id":4,"titulo":"Different strategies of Lotus japonicus, L. corniculatus and L. tenuis to deal with complete submergence at seedling stage","resumen":"Two main strategies allow plants to deal with submergence: (i) escape from under water by means of shoot elongation or (ii) remaining quiescent underwater until water subsides and then resume growth. We investigated these strategies in seedlings of Lotus japonicus, L. corniculatus and L. tenuis subjected to control and submergence for 12 days, and a subsequent 30-day recovery period. All three species survived submergence but exhibited different strategies. Submerged seedlings of L. japonicus exhibited an escape strategy (emerging from water) as a result of preferential carbon allocation towards shoot mass and lengthening, in detriment of root growth. In contrast, seedlings of L. corniculatus and L. tenuis became quiescent with no biomass accumulation, no new unfolding of leaves and no shoot elongation. Upon de-submergence, seedlings of L. japonicus had the lowest recovery growth (a biomass and shoot height 58% and 40% less than controls, respectively), L. corniculatus was intermediate, and L. tenuis showed the greatest recovery growth. Previously submerged seedlings of L. tenuis did not differ from their controls either in final shoot biomass or shoot height. Thus, for the studied species, quiescence appears to be an adequate strategy for tolerance of short-term (i.e. 12 days) complete submergence, being consistent with field observations of L. tenuis colonization of flood-prone environments.&nbsp;","palabras_clave":"Lotus spp.|quiescence|seedlings|submergence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88200,"idioma_id":4,"titulo":"Unvarying diet of a Neotropical desert marsupial inhabiting a variable environment: the case of Thylamys pallidior","resumen":"Studies on the diet and other aspects of the  natural history of Neotropical marsupials have focused  mainly on a few species from tropical and forest habitats.  Research on desert marsupials, on the other hand, is almost  absent outside Australia. The desert mouse opossum,  Thylamys pallidior, is a small marsupial which inhabits  the arid lands of Argentina, Chile, Bolivia, and Peru. In  Argentina, it occurs in the Monte desert, a highly seasonal  system with a heterogeneous landscape which affords a  good opportunity to perform comparisons among different  environmental situations. We analyzed fecal samples from  123 individuals and compared their diet among different  seasons, habitat types, sexes, and ages. The diet of T.  pallidior was composed of 68.7% of arthropods and 31.3%  of plant material, mainly leaves (24.6%). We found no  significant differences in the proportions of any main food  category consumed for any of the factors analyzed.  Consumption of both plant and animal material seems to  be important in the diet of T. pallidior which manages to  keep their proportions constant despite the strong variability  and seasonality of the habitat. Contrary to most didelphid  species, but similarly to most mammals of this area, leaves  seem to represent an important source of food possibly  because of their abundance and stability in the Monte  desert. This represents the first study to focus on the diet of  a Thylamys species inhabiting an arid environment.","palabras_clave":"aridlands|Didelphid marsupials|Diet  |Monte desert"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88201,"idioma_id":5,"titulo":"Historia  natural de un roedor raro del desierto argentino, Salinomys delicatus (Cricetidae, Sigmodontinae)","resumen":"El ratón delicado de los salares (Salinomys delicatus) es un pequeño roedor endémico de Argentina. Ha sido considerada como vulnerable a la extinción dada su distribución restringida y en parches, tamaño poblacional pequeño y especialización en hábitats salinos. A pesar de que el ratón delicado tiene adaptaciones morfológicas y fisiológicas para la supervivencia en ambientes áridos y salitrosos, poco es lo que se conoce de su historia natural. El presente trabajo tiene como objetivo estudiar la historia natural de S. delicatus, reportar nuevas localidades de ocurrencia, caracterizar el uso de hábitat, su dieta y el ensamble acompañante, y describir su biología reproductiva y morfología. Se registraron dos nuevos sitios de ocurrencia en ambientes de bosques en galería y bajos salinos en la región noreste de la provincia de Mendoza (Argentina), siendo las primeras citas para esta provincia. S. delicatus presenta una dieta omnívora, como es frecuente en otros roedores de desierto, y consume en igual medida semillas, artrópodos y plantas halófitas. El ensamble acompañante está compuesto por no más de tres especies de pequeños mamíferos que varían según la localidad, siendo esta riqueza similar a otros sitios del Monte. La proporción de sexos y el patrón de dimorfismo sexual mostraron un marcado desvío hacia las hembras (H:M = 3.6:1.1 y H:M = 1.151 respectivamente). La morfología externa y craneal presenta una importante variabilidad intra e interpoblacional, sugiriendo que el aislamiento juega un rol importante. Cuando se consideraron adultos y juveniles conjuntamente dos de las seis medidas externas (longitud total y longitud de cabeza y cuerpo) y siete de las 22 medidas craneales resultaron significativamente mayores en hembras que en machos. Cuando se compararon sólo los adultos, cuatro características externas (longitud total, longitud de cabeza y cuerpo, largo de la cola y peso) y seis medidas craneales fueron significativamente mayores en hembras que en machos. Este trabajo refuerza la importancia del desarrollo de nuevos estudios mas detallados sobre la historia de vida de S. delicatus y permite reafirmar la importancia de conservación de esta especie.  ","palabras_clave":"Conservación|Historia de vida|Ratón delicado|Salares|Zonas áridas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88202,"idioma_id":4,"titulo":"Landscape genetic structure of natural populations of Acacia caven in Argentina","resumen":"Acacia caven is a South American species whichshows remarkable climate tolerance and ecological adaptability;as such, this species is suitable for colonizinganthropogenically degraded sites. This species is widelydistributed, and six varieties have been described based onboth morphological traits and molecular markers. Moreover,Aronson (1992) suggests that, for this species, geographicalseparation could be associated with ecological differentiation.In this study, amplified fragment length polymorphismswere used to study genetic variation within andamong 15 populations of A. caven from five eco-regionsof Argentina and to investigate (1) whether the varieties aregenetically coherent, (2) whether the varieties correspondconsistently to a single eco-region, (3) the proportion of thespecies diversity explained within and among varieties andeco-regions. Eight of the 225 bands appear to be underpositive selection. The remaining 217 neutral loci showeda high percentage of polymorphism (99.1%). The estimatesof genetic diversity Hj were generally high. The FST (0.315)was highly significant, providing evidence for genetic structureamong populations. Hierarchical analysis of molecularvariance indicated that variation among eco-regions was8.2% and highly significant. The higher component ofvariance was found within populations (67.5%). STRUCTUREanalysis suggested that the optimal number of K011.The results showed that, in most cases, geographic separationis associated with ecological differentiation. Since differentiationof A. caven populations studied here in ecoregionswas highly significant, sampling should include alarge number of trees within populations as well as coveringthe wide ecological diversity of the species.","palabras_clave":"Genetic structure|AFLP|Acacia caven|Eco-regions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88203,"idioma_id":4,"titulo":"Strategies for conservation for disturbed Prosopis alba (Leguminosae, Mimosoidae) forests based on mating system and pollen dispersal parameters","resumen":"Prosopis species forests in Argentina are increasinglyfragmented in the last years mainly by the deforestationactivity without any reforestation strategy, theestablishment of different crop plantations, and naturalfires. The consequence of habitat fragmentation on thegenetic potential of Prosopis alba requires a fine-scaleanalysis of population structure, in particular mating systemand pollen dispersal. By means of short sequences repeats,we analyzed a fragmented population of this species inSantiago del Estero (Argentina). Most genetic variation wasobserved among families within zones (65.5%), whereasthe lowest proportion corresponded to the differentiationamong zones (2.8%). The fine analysis of structure atfamily level suggests that this population is completeoutcrosser and there is a low but significant biparentalinbreeding. Outcrossing rates differ among mother plantsand the proportion of full sibs within mother plants rangedfrom 64% for seeds proceeding from the same pod to 10%for seeds from different pods. The average pollen dispersaldistance was estimated to be among 5.36 and 30.92 m byusing the KinDist or TwoGener approach. About sevenpollen donors are siring each progeny array and the numberof seed trees necessary for seed collection aiming to retainan effective population size of 100 was estimated in 16?39individuals depending on the relatedness estimator used.Pollen and seed dispersal would be limited, what determinesthe need of conserving short distant patches to avoid theeffects of inbreeding and drift within populations as aconsequence of intensive use resource for agriculture.","palabras_clave":"Pollen dispersal|Microsatellites|Conservation|Native forest"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88204,"idioma_id":4,"titulo":"Feeding habits of two sympatric dolphin species off North Patagonia - Argentina.","resumen":"This paper provides an appraisal of the diet and feeding habits of common and dusky dolphins, two sympatric species inhabiting North Patagonia, in order to analyze how these species are using the available food resources.","palabras_clave":"Argentine Sea|Dolphins|Diet|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88205,"idioma_id":4,"titulo":"Tooth morphology of Echimyidae (Rodentia, Caviomorpha): homology assessments, fossils and evolution","resumen":"Echimyidae constitute the most important radiation of caviomorph rodents in the Neotropical region, represented by 20 extant genera and several extinct species. Both in extant and fossil forms, this diversity is reflected by a significant morphological variation found in crown structures of the cheek teeth. Different hypotheses of primary homology have been proposed for these structures, which, in turn, support diverse dental evolutionary hypotheses. In this contribution we inspect the main structures (cusps and lophids) of the lower deciduous teeth and molarsin extinct and extant Echimyidae, and establish their topological correspondences. Comparisons with cusps and lophids of Erethizontidae are emphasized. We explore the testing of alternative primary hypotheses of lophid correspondences in a cladistic context. Following a \u2018dynamic\u2019 approach, we select the hypothesis of primary homology, which produced the more parsimonious results, and evaluate the evolutionary transformations of the dental characters analysed. In this context, the phylogenetic relationships of living Myocastor coypus (Molina, 1782) with the extinct Tramyocastor and Paramyocastor are tested. Our results indicate that pentalophodonty is the derived condition for the lower molars in Echimyidae, that trilophodonty evolved independently at least three times during the evolutionary history of these rodents, and that tetralophodonty represents the plesiomorphic condition. This study shows that dental evolution in echimyids can be better understood when occlusal structures are expressed as reliably comparable characters, and when fossils are taken into account","palabras_clave":"ARGENTINA|TEETH|MYOCASTORINAE|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88206,"idioma_id":4,"titulo":"FIRST CONTINENTAL VERTEBRATES FROM THE MARINE PARANA FORMATION (LATE MIOCENE, MESOPOTAMIA, ARGENTINA): CHRONOLOGY, BIOGEOGRAPHY, AND PALAEONVIRONMENTS","resumen":"First records of continental vertebrates from the upper levels of the Paraná Formation (Late Miocene) at La Juanita locality, Entre Ríos Province (Mesopotamia, Argentina), are reported and evaluated from chronological, paleobiogeographical, and paleoenvironmental perspectives. Among caviomorph rodents, caviids, hydrochoerids, and the extinct octodontoid Plesiacarechimys are described. The pampatheriid Scirrotherium sp. and a phoenicoptherid bird are identified. A pre-Huayquerian age (older than 8.7 Ma) is proposed for the fossil bearing levels. The Paranense Sea, one of the most widespread Middle-Late Miocene Atlantic transgressions that covered southern South America, is interpreted as an important geographical barrier promoting vicariance of the Plesiacarechimys lineage. Cavioids recovered from the Parana´ Formation represent the first stages of the radiation of these rodents at the latitude of Entre Ríos Province in the context of the whole South American subcontinent. The genesis of the fossiliferous level corresponds to a storm deposit in a littoral marine environment. Capybaras and flamingos suggest the presence of water bodies, saline lagoons, mudflats, or shallow brackish coastal or inland lakes, in accordance with the geological data of the Paraná Formation.","palabras_clave":"PARANAENSE|VERTEBRATES|MIOCENE|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88207,"idioma_id":4,"titulo":"Dracolestes Goin, Candela, Abello and Oliveira 2009 is a nomen nudum","resumen":"Goin et al. (2009) described the oldest Paucituberculata marsupialsfrom the Las Flores and La Barda localities of Argentina(late Palaeocene, and early\u2013middle Eocene), as well as fromthe Itabora´&#305; Basin of Brazil (late Palaeocene). The new taxa,represented by very scarce, although well-preserved, dental remainswere named Riolestes capricornicus, Bardalestes hunco,Bardalestes sp., and Dracolestes sp. They identified the specimenMLP 90-II-5-300 as Dracolestes sp. (Goin et al., 2009:table 1,p. 871), and designated Dracolestes as a plesion of the OrderPaucituberculata (Goin et al., 2009:table 3, p. 879).","palabras_clave":"Nomenclature|Paucituberculata|Taxonomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88208,"idioma_id":4,"titulo":"Control of cell growth direction by direct fabrication of periodic micro and submicrometer arrays on polymers","resumen":"In this work we describe a laser-assisted microstructuring technique called Direct Laser Interference Patterning (DLIP) to produce topographical cues for tumor cells in a one-step process. Line-like patterns with spatial periods ranging from 500 nm to 10 µm are fabricated on polyimide films. The resulting structures exhibit a well defined shape and quality even for patterns with small periodic distances. Subsequently, the behavior of mouse mammary adenocarcinoma cells over those structures is evaluated. The results show that cell growth is well aligned to the direction of the patterns (over 60 % lying within 0° to 15° to either side of the surface lines) for all evaluated structure sizes. Moreover, cells grown on patterns with 500 nm spatial period are the most narrowly aligned (up to 80 % found between 0° and 15°), showing the potential of the technique. The fabrication process of the PI patterns is supported by a mathematical model of the underlying photo-chemical ablation process.","palabras_clave":"Cell guidance,| surface patterning,| Direct Laser Interference Patterning, polyimide films,| mouse mammary adenocarcinoma cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88209,"idioma_id":4,"titulo":"Low-frequency ultrasound induces oxygen vacancies formation and visible light absorption in TiO 2 P-25 nanoparticles","resumen":"Low-frequency ultrasound (LFUS) irradiation induces morphological, optical and surface changes in the commercial nano-TiO2-based photocatalyst, Evonik\u2013Degussa P-25. Low-temperature electron spin resonance (ESR) measurements performed on this material provided the first experimental evidence for the formation of oxygen vacancies (Vo), which were also found responsible for the visible-light absorption. The Vo surface defects might result from high-speed inter-particle collisions and shock waves generated by LFUS sonication impacting the TiO2 particles. This is in contrast to a number of well-established technologies, where the formation of oxygen vacancies on the TiO2 surface often requires harsh technological conditions and&nbsp; complicated procedures, such as annealing at high temperatures, radio-frequencyinduced plasma or ion sputtering. Thus, this study reports for the first time the preparation of visible-light responsive TiO2-based photocatalysts by using a simple LFUS-based approach to induce oxygen vacancies at the nano-TiO2 surface. These findings might open new avenues for synthesis of novel nano-TiO2-based photocatalysts capable of destroying water or airborne pollutants and microorganisms under visible light illumination.","palabras_clave":"Visible-light responsive TiO2|Low-frequency ultrasound|Oxygen vacancies|nano-TiO2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88210,"idioma_id":4,"titulo":"Early experience with diverse foods increases intake of non-familiar flavors and feeds in sheep","resumen":"This study determined whether early experiences by sheep with monotonous or diverse diets influence intake of unfamiliar flavors and feeds later in life. Thirty 2-mo-old lambs were randomly assigned to 3 treatment diets (n = 10): diverse (DIV), diverse with plant toxins (DIV+T), and monotonous (MON). Lambs in DIV received in 9 successive periods of exposure 4-way choice combinations of 2 foods high in energy and 2 foods high in protein from an array of 6 foods: 3 high in energy [beet pulp, oat grain, and a mix of milo:grape pomace (60:40)] and 3 high in digestible protein (DP) (soybean meal, alfalfa, corn gluten meal). Lambs in DIV+T received the same exposure as DIV, but 2 plant toxins, oxalic acid (1.5%) and quebracho tannins (10%), were randomly added to 2 of the feeds in each of the choice combinations. Lambs in MON received a monotonous balanced diet, made with a mixture of all 6 feeds detailed before. All treatments received their feed in 4 separate buckets. During exposure, treatments did not differ in total daily DMI (P = 0.31), but daily intake of ME was less (P  0.05). After exposure, lambs were offered a familiar feed (wheat bran) containing novel flavors (maple, garlic, or bitter) and 2-way choices of novel feeds (fescue hay vs. corn distillers grains, rice vs. calf manna, and green peas vs. rolled oats). Intake of maple-flavored wheat bran tended (P = 0.08) to be greater for lambs in DIV than for lambs in DIV+T and MON. Intake of bitter-flavored and garlic-flavored wheat bran were greater (P = 0.03 and P = 0.04, respectively) for lambs in DIV and DIV+T than for lambs in MON. During 2-way choice trials, lambs in DIV, but not in DIV+T, showed greater intakes of fescue hay (P = 0.05) and rice (P = 0.04) than lambs in MON. Intake of green peas was greater (P = 0.03) for lambs in DIV and DIV+T than for lambs in MON. At the end of testing, lambs in DIV but not in DIV+T showed greater ADG than lambs in MON (P = 0.05). Thus, early exposure to diverse foods enhanced acceptance of novel flavors relative to early exposure to a monotonous ration. Early experience with diverse feeds plus plant toxins led to a less diverse diet than early experience with diverse feeds. Early exposure to diverse feeds may be beneficial in production systems that require rapid acceptance and high intake of unfamiliar feeds. © 2012 American Society of Animal Science. All rights reserved.","palabras_clave":"DIETARY DIVERSITY|EARLY FOOD EXPERIENCE|NEOPHOBIA|SHEEP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88211,"idioma_id":4,"titulo":"Depression of rumen ammonia and blood urea by quebracho tannin containing supplements fed after high-nitrogen diets with no evidence of self-regulation of tannin intake by sheep","resumen":"The aim of this study was to assess whether sheep enhance nitrogen use in response to tannin supplementation, and if they increase preference for tannin-rich supplements when consuming diets high in rumen-degradable protein. In Experiment 1 twenty four Corriedale crossbred wethers (10 months of age; 41 ± 2.1. kg) were randomly divided into two groups (n= 12\/group). Group 1 received a high-protein basal diet of high rumen-degradable protein (' HP' ), whereas the other group received a low-protein basal diet of low rumen-degradable protein (' LP' ). During Period 1 (12 days) half of the animals from each group received a wheat bran supplement containing 11% quebracho tannins (T) and the other half had the same supplement but without tannins (NT). Wethers fed supplements T or NT during Period 1 received NT or T, respectively, during Period 2. Rumen fluid and jugular blood samples were collected on the last day of each period to determine ruminal ammonia nitrogen and blood urea nitrogen (BUN) concentration, respectively. Experiment 2 was similar to Experiment 1, except that a new set of wethers was used (11 months of age; 41 ± 2.4. kg), oat straw replaced wheat bran, and only BUN was determined. After Period 2 of Experiment 2, all animals had a simultaneous offer of T and NT and preference for T was estimated for 3 days. In Experiment 1, wethers in HP consumed greater (P< 0.05) amounts of basal diet than wethers in the LP during Period 1. Wethers exposed to HP displayed lower values of BUN and ruminal ammonia nitrogen when consuming T than when ingesting NT (Periods 1 and 2, respectively; P< 0.01). In Experiment 2, wethers under the HP diet and supplemented with T consumed the greatest amounts of basal diet (Period 1; P< 0.05). Intake of tannin was higher in LP than in HP (P< 0.05) and wethers exposed to HP displayed lower values of BUN when consuming T than when ingesting NT (Period 2; P< 0.05). Preference for and intake of the tannin-containing food tended (P= 0.11) to be greater for wethers exposed to HP than for wethers under LP during the last day of testing. Tannin supplements have the potential to reduce rumen ammonia nitrogen and BUN in sheep, even when fed after ingestion of high-N diets and in the form of low-quality supplements. © 2012 Elsevier B.V.","palabras_clave":"BLOOD UREA|PREFERENCE|RUMEN AMMONIA|SELF-MEDICATION|TANNIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88212,"idioma_id":4,"titulo":"Induction of low-nutritious food intake by subsequent nutrient supplementation in sheep (Ovis aries)","resumen":"Acceptance of and preference for a particular food depends not only on its intrinsic (e.g. nutritional) properties but also on expected or recent food experiences. An instance of this type of phenomenon has been called induction effect, which consists of an increased intake of a type of food when it precedes a hedonically preferred food in a sequence familiar to the animal, relative to controls that have access only to the less-preferred food. The purpose of our study was to assess intake induction of a low-nutritious food when followed by different high-nutritious supplements in sheep (Ovis aries). In this experiment, we ran a supplemented phase where animals fed oat hay (a low-nutritious food) in the first part of the daily feeding sessions followed by a supplement with either a high (soya bean meal; group GS) or a low (ground corn; group GC) protein\u2013energy ratio in the second part ate more oat hay than controls that were fed oat hay in both parts of sessions (group GH). In addition, supplemented animals presented a stronger preference for oat hay over alfalfa hay than controls in a subsequent choice. When all animals received no food in the second part of the sessions (Non-supplemented phase), intake of oat hay converged to the control\u2019s intake level in all the groups, suggesting that the presence of supplements after access to oat hay was responsible for intake induction. Lastly, we repeated the supplemented phase with a different control group where animals received oat hay in the first part of the sessions and no food in the second part (group NF), thus equalizing groups in terms of the time of access to oat hay in a session. Groups GS and GC still developed higher intake of oat hay than group NF. In both supplemented phases of the experiment, we estimated animals\u2019 daily metabolizable energy (ME) and crude protein (CP) intake. CP intake was higher in group GS than in groups GC, GH and NF, but there was no difference between group GC and the controls. In turn, groups did not differ in ME intake in the First supplemented phase, and only group GS presented higher ME intake than the rest of the groups in the Second supplemented phase. Therefore, a nutritional account of the present induction effect seems insufficient. We propose that a learned association between oat hay and the post-ingestive feedback from the subsequent high-nutritious supplements underlay sheep\u2019s intake induction and increased preference for oat hay. &nbsp;&nbsp;","palabras_clave":"intake induction|low-nutritious food|nutrient supplementation|sheep"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88213,"idioma_id":4,"titulo":"Mating system of the burrowing crab Neohelice granulata (Brachyura, Varunidae) in two contrasting environments: effect of burrow architecture.","resumen":"Few studies conducted in crustaceans have demonstrated how habitat eatures could shape the mating systems. Here, the burrow of Neohelice granulata was considered as a resource used for mating, and its architecture was characterized in two contrasting study sites: Mar Chiquita Lagoon (MCL), an estuary composed of muddy sediments, and San Antonio Oeste (SAO), a marine bay composed of gravel sediment. Burrow features diVered between study sites and occupant gender. Large males constructed burrows with a chamber in MCL and with a widened entrance in SAO, while small males constructed the same narrow burrows as females at both study sites. Field experiments demonstrated that burrows with chambers or widened entries are places used for copulation, although successful post-copulatory guarding was displayed only in those with chambers. The intensity of the agonistic encounters and the success of males in winning resources (burrows\/females) also depend on the habitat characteristics. N. granulata shows a resource defense mating system where males employ diVerent mating strategies according to the burrow architecture to ensure mating success.","palabras_clave":"Mating|Brachyura|Neohelice|burrow"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88214,"idioma_id":4,"titulo":"Effect of Surface Charge on the Interfacial Orientation and Conformation of FB1 in Model Membranes","resumen":"The toxicity of FB1 is usually explained through the enzymatic disruption of lipidic metabolism. However, it may lie in the thermodynamics of the membrane and its cooperative phase behavior rather than in the activity of individual proteins. Here, we investigate the effects FB1 at the molecular and mesoscopic levels in FB1-phospholipid mixed Langmuir films. Mean molecular area vs. FB1 molar fractions (xFB1) and phase diagram analysis allowed defining miscibility conditions and phase states at different xFB1. Surface potential measurements, evaluated as a function of the molecular packing and xFB1, revealed the FB1-induced change in the collective dipolar reorientation leaded to neutralization of charged films. Size, shape and distribution of 2D-domain analysis from epifluorescence data suggested the increase in the mixing entropy and film relaxation rate. Finally, PM-IRRAS revealed the orientation of FB1 with the amine-end (zwitterionic and negatively charged monolayers) or the tricarballylic acid-end (positively charged monolayers) pointing to the air. The globular-extended conformational equilibrium of FB1 is dynamically defined by the membrane charge becoming a toxicity enhancing factor. The specificity of the toxin-protein interaction might also be perturbed by the FB1-induced remodeling of the membrane topography by affecting the raft-like platforms where membrane enzymes are considered to be located.","palabras_clave":"MYCOTOXINS|LANGMUIR FILMS|EPIFLUORESCENCE MICROSCOPY|PM-IRRAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88215,"idioma_id":4,"titulo":"Modeling sequences of user actions for statistical goal recognition","resumen":"User goals are of major importance for an interface agent because they serve as a context to define what the user\u2019s focus of attention is at a givenmoment. The user\u2019s goals should be detected as soon as possible, after observing few user actions, in order to provide the userwith timely assistance. In this article,we describe an approach for modeling and recognizing user goals from observed sequences of user actions by using Variable Order Markov models combined with an exponential moving average (EMA) on the prediction probabilities. The validity of our approach has been tested using data collected from real users in the Unix domain. The results obtained show that an interface agent can achieve near 90% average accuracy and over 58% online accuracy in predicting the most probable user goal after each observed action, in a time linear to the number of goals being modeled. We also found that the use of an EMA allows a faster convergence in the actual user goal.","palabras_clave":"GOAL RECOGNITION|VARIABLE ORDER MARKOV MODELS |INTERFACE AGENTS|USER MODELING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88216,"idioma_id":4,"titulo":"Topology-based recommendation of users in micro-blogging communities","resumen":"Nowadays, more and more users share real-time news and information in micro-blogging communities such as Twitter, Tumblr or Plurk. In these sites, information is shared via a followers\/followees social network structure in which a follower will receive all the micro-blogs from the users he\/she follows, named followees. With the increasing number of registered users in this kind of sites, ¯nding relevant and reliable sources of information becomes essential. The reduced number of characters present in micro-posts along with the informal language commonly used in these sites make it dificult to apply standard content-based approaches to the problem of user recommendation. To address this problem, we propose an algorithm for recommending relevant users that explores the topology of the network considering di®erent factors that allow us to identify users that can be considered good information sources. Experimental evaluation conducted with a group of users is reported,&nbsp; demonstrating the potential of the approach. ","palabras_clave":"social networking|social technology|recommender system"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88217,"idioma_id":4,"titulo":"A deterministic crowding evolutionary algorithm to form learning teams in a collaborative learning context","resumen":"The aim of forming collaborative learning teams is that participating students acquire new knowledge and skills through the interaction with their peers. To reach this aim, teachers usually utilize a grouping criterion based on the students\u2019 roles and on forming&nbsp; well-balanced teams according to the roles of their members. However, the implementation of this criterion requires a considerable amount of time, effort and knowledge on the part of the teachers. In this paper, we propose a deterministic crowding evolutionary algorithm with the aim of assisting teachers when forming well-balanced collaborative learning teams. Considering a given number of students who must be divided into a given number of teams,the algorithm both designs different alternatives to divide students into teams and evaluates each alternative as regards the grouping criterion previously mentioned. This evaluation is carried out on the basis of knowledge of the students\u2019 roles. To analyze the performance of the proposed algorithm, we present the computational experiments developed on ten data sets with different levels of complexity. The obtained results are really promising since the algorithm has reached optimal solutions for the first four data sets and near-optimal solutions for the remaining six data sets.","palabras_clave":"COLLABORATIVE LEARNING|LEARNING TEAM FORMATION|ROLES|EVOLUTIONARY ALGORITHMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88218,"idioma_id":4,"titulo":"Sewage pollution effects on mesozooplankton structure in a shallow temperate estuary","resumen":"The effects of a sewage effluent with no treatment on the mesozooplankton structure and theenvironmental quality were evaluated in the Bahía Blanca Estuary, during June to November 1995. The highest values of particulate organic matter, nutrients and specially phosphate, were observed in the effluent discharge zone. In addition, taxa richness, mesozooplankton abundance and Shannon diversity values were lower in the sewage discharge area compared with the less polluted area. Eurytemora americana and Acartia tonsa as well as larvae of Balanus glandula, Neohelice granulata and Spionidae were found in the discharge area with lower densities.These results highlight the importance of sewage effluent effects on mesozooplankton community providing background data to use in other monitoring programmes.","palabras_clave":"Mesozooplankton|Diversity|Sewage effluent|Bahía Blanca estuary"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88219,"idioma_id":4,"titulo":"ELA-DRA polymorphisms are not associated to Equine Arteritis Virus infection in horses from Argentina","resumen":"Polymorphisms  at  Major  Histocompatibility  Complex  (MHC)  genes  have  been associated  with  resistance\/susceptibility  to  infectious  diseases  in  domestic  animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the  Equine  Lymphocyte  Antigen  is  associated  with  susceptibility  to  Equine  Arteritis Virus (EAV)  infection  in horses  in Argentina. The equine DRA gene was screened for polymorphisms  using  Pyrosequencing®  Technology  which  allowed  the  detection  of three ELA-DRA exon 2 alleles. Neither allele  frequencies nor genotypic differentiation exhibited any statistically  significant  (P-values=0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher\u2019s exact  test and OR calculations did not  show  any  significant  association.  As  a  consequence,  no  association  could  be established between the serological condition and ELA-DRA.","palabras_clave":"EQUINE LYMPHOCYTE|EQUINE VIRAL ARTERITIS|GENETIC SUSCEPTIBILITY|POLYMORPHISM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88220,"idioma_id":4,"titulo":"Spatial patterns of the Argentine hake Merluccius hubbsi and oceanographic processes in a semi-enclosed Patagonian ecosystem","resumen":"Time-series of fishing position, landings, satellite-derived sea surface temperature and chlorophyll a concentrations were used to relate the spatial-temporal distribution of the Argentine hake Merluccius hubbsi with seasonal oceanographic processes in San Matías Gulf. Also, the seasonal effect of fishing on the hake population structure was analysed. During summer the fleet was concentrated over the area of the frontal system, obtaining the best catch-per-unit-effort (CPUE) of hake in relatively deep waters. In autumn, the dispersion of the fleet due to a reduction in CPUE coincided with the dissipation of the front, suggesting that the distribution and shoaling of the Argentine hake is associated with seasonal thermal structures. In spring, the thermal structure of the waters and the Chlorophyll a blooms seem to modulate the timing of spawning of hake, which occurs mainly in October-November. In addition, the fleet captured a higher proportion of females in the gonadal recovery stage during warm months (November to April). While winter catches (May to October) consisted mainly of males, the intense summer fishing may result in a high impact on the female population. This information is relevant to design of spatial management tools intended to provide biological sustainability to the hake fishery.","palabras_clave":"NATURAL RESOURCES DISTRIBUTION|TIDAL FRONT|TRAWL FISHERY|SATELLITE-DERIVED DATA|SUSTAINABLE MANAGEMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88221,"idioma_id":5,"titulo":"Reseña sobre Otros escritos","resumen":"La literatura argentina ha sufrido la persistente influencia del lacanismo. La reciente traducción de los Otros escritos sirve de ocasión para revisar el problema de las relaciones de psicoanálisis y literatura. Hoy, cuando las ciencias sociales se han convertido en fuente privilegiada de teoría y metodología para los estudios literarios, son del mayor interés las consideraciones epistemológicas de Lacan en el momento de máximo imperialismo del psicoanálisis, precisamente porque contradicen el reflujo contrario que hoy reivindica generalizadamente la colonización por parte de las ciencias ´duras´ de campos hasta no hace mucho reservados a las sociales (con el ejemplo privilegiado de las neurociencias) e incluso tilda a Lacan de impostor (Sokal). ¿Hasta dónde es posible hacerse cargo hoy del impacto epistemológico del acontecimiento estructural desde los estudios literarios? ¿Cómo podría esto relacionarse con las influyentes lecturas de Lacan que se han venido llevando a cabo últimamente en los ámbitos de la filosofía, la teoría política y el análisis cultural? ¿Qué consecuencias se pueden extraer de la enseñanza de Lacan para pensar las condiciones institucionales de la investigación literaria? La consideración lacaniana de lo imaginario podría ser enormemente fértil para repensar hoy lo literario. En 'Lituratierra', Lacan propone una teoría de la escritura que discute con Derrida y sus versiones dominantes en la teoría literaria.","palabras_clave":"PSICOANÁLISIS|LACANISMO|CIENCIAS SOCIALES|IMAGINARIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88222,"idioma_id":4,"titulo":"Effects of plant species traits on ecosystem processes: Experiments in the Patagonian steppe","resumen":"Several experiments have shown that aboveground net primary productivity increases with plant species richness. The main mechanism proposed to explain this relationship is niche complementarity, which is determined by differences in plant traits that affect resource use. We combined field and laboratory experiments using the most abundant species of the Patagonian steppe to identify which are the traits that determine niche complementarity in this ecosystem. We estimated traits that affect carbon, water, microclimate, and nitrogen dynamics. The most important traits distinguishing among species, from the standpoint of their effects on ecosystem functioning, were potential soil nitrification, rooting depth, and soil thermal amplitude. Additionally, we explored the relationship between trait diversity and aboveground net primary production (ANPP) using a manipulative field experiment. ANPP and the fraction of ANPP accounted for by trait diversity increased with number of traits. The effect of trait diversity decreased as the number of traits increased. Here, the use of traits gave us a mechanistic understanding of niche complementarity in the Patagonian steppe.Read More: http:\/\/www.esajournals.org\/doi\/abs\/10.1890\/11-0722.1","palabras_clave":"aboveground net primary production (ANPP),|niche complementarity|rooting depth,|soil nitrification"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88223,"idioma_id":4,"titulo":"Retinal Changes in an Experimental Model of Early Type 2 Diabetes in Rats Characterized by Non-Fasting Hyperglycemia","resumen":"Diabetic retinopathy is a leading cause of acquired blindness in young, but also in elder adults, mostly affected by type 2 diabetes mellitus (T2DM). The aim of this work was to develop an experimental model of early human T2DM in adult rats, and to analyze retinal functional, morphological, and biochemical changes arising during the early stages of the moderate metabolic derangement. For this purpose, animals were divided in four groups: adult male Wistar rats receiving: tap water and citrate buffer i.p. (group 1), tap water with 30% sucrose and citrate buffer i.p. (group 2), tap water and 25mg\/kg i.p streptozotocin (STZ, group 3), or 30% sucrose and STZ (group 4). Fasting and postprandial glycemia, fructosamine and serum insulin levels were assessed. In addition, i.p. glucose and insulin tolerance tests were performed. Retinal function (electroretinogram, ERG) and morphology (optical microscopy), retinal nitric oxide synthase (NOS) activity (using (3)H-arginine), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and TNF&#945; levels (ELISA) were evaluated. At 6 and 12 weeks of treatment, animals which received a sucrose-enriched diet and STZ showed significant differences in most metabolic tests, as compared with the other groups. At 12 weeks of treatment, a significant decrease in the ERG a- and b- wave and oscillatory potential amplitudes, and a significant increase in retinal NOS activity, TBARS, TNF&#945;, glial fibrillary acidic protein in Müller cells, and vascular endothelial growth factor levels were observed. These results indicate that the combination of diet-induced insulin resistance and a slight secretory impairment resulting from a low-dose STZ treatment mimics some features of human T2DM at its initial stages, and provokes significant retinal alterations.","palabras_clave":"TYPE 2 DIABETES MELLITUS|EXPERIMENTAL MODEL|DIABETIC RETINOPHATY|ELECTRORETINOGRAM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88224,"idioma_id":5,"titulo":"Supporting Virtual Meetings in Distributed  Scrum Teams","resumen":"Scrum has gained surprising momentum as an agile project management approach. It provides effective social integration by building up social team capital, and it provides much needed control and coordination mechanisms. Especially, daily Scrum meetings ensure an open channel for communication. However, this channel has been threatened by distributed software development which has highly been adopted in software industries. To support virtual meetings regardless physical locations of team members, we developed a 3D tool based on Scrum life cycle. The tool provides a virtual world consisted in technology to hold meetings in a Scrum context. We used a questionnaire to evaluate the usability and effectiveness of the tool with undergraduate students.","palabras_clave":"Scrun|Agile Project Management|Virtual Meetings"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88225,"idioma_id":10,"titulo":"O processo de restabelecimento na perspectiva de pessoas com diagnóstico de transtornos do espectro esquizofrênico e de psiquiatras na rede pública de atenção psicossocial","resumen":"O tema do restabelecimento (recovery) na perspectiva das pessoas portadoras de transtornos mentais graves vem sendo cada vez mais investigado embora ainda careça de estudo no contexto dos serviços comunitários de saúde mental e da transformação da assistência psiquiátrica. Objetivo: analisar como o processo de restabelecimento (recovery) é percebido por usuários com diagnóstico de transtornos do espectro esquizofrênico e psiquiatras inseridos na rede de atenção psicossocial. Método: Pesquisa qualitativa multicêntrica, informada pelo quadro de referência da Análise Fenomenológica Interpretativa, no qual se utilizou as técnicas de observação participante, entrevistas semi-estruturadas e grupos focais para obtenção dos dados. Resultados: A partir do material analisado identificou-se as seguintes categorias temáticas: efeitos do adoecimento; contexto de tratamento no CAPS; diagnóstico; possibilidades e expectativas em relação ao futuro\/prognóstico e abertura para a experiência do outro (posição dialógica). Conclusão: Existem pontos de convergência e divergência entre as perspectivas de usuários e psiquiatras a respeito do processo de restabelecimento. Mesmo assim, é possível criar contextos em que a experiência dos usuários ilumine o conhecimento técnico\/experiência do psiquiatra e vice-versa.","palabras_clave":"Reestablecimento|Experiencia de la enfermedad|Narrativa|Esquizofrenia|Serviços comunitários de saúde mental"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88226,"idioma_id":4,"titulo":"Assisting Conformance Checks between Architectural Scenarios and Implementation","resumen":"Context: Conformance between architecture and implementation is a key aspect of architecture-centricdevelopment. Unfortunately, the architecture \u2018\u2018as documented\u2019\u2019 and the architecture \u2018\u2018as implemented\u2019\u2019tend to diverge from each other over time. As this gap gets wider, the architects\u2019 reliance on architecture-level analyses is compromised. Thus, conformance checks should be run periodically on the systemin order to detect and correct differences. In practice, tool support is very beneficial for these checks.Objective: Despite having a structural conformance analysis, assessing whether the main scenariosdescribing the architectural behavior are faithfully implemented in the code is still challenging. Checkingconformance to architectural scenarios is usually a time-consuming and error-prone activity. In this article,we describe a tool approach called ArchSync that helps architects to reconcile a scenario-based architecturaldescription with its source code, as changes are being made on the code.Method: The architecture is specified with Use-Case Maps (UCMs), a notation for modeling both highlevelstructure and behavior. ArchSync applies heuristics that incrementally detect code deviations withrespect to predetermined UCMs, based on the analysis of system execution traces for those UCMs. Also,ArchSync provides suggestions for re-synchronizing the UCMs with the code.Results: We have evaluated a prototype of ArchSync in three medium-size case-studies, involving developerswith moderate architecture experience. We compared time consumed, code browsed and suggestionsfor re-synchronizing the UCMs by these developers, with and without the support of ArchSync.Conclusion: The results from case-studies and lessons learned have shown that the ArchSync approach ispractical and reduces conformance checking efforts.","palabras_clave":"Software architecture|Conformance checking|Behavioral scenarios|Tool support|UCMs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88227,"idioma_id":4,"titulo":"Teaching Scrum to Software Engineering Students with Virtual Reality Support","resumen":"Scrum has received significant academic attention because of its widespread application in software development industries. Teaching agile software development can be illustrated by teaching with lecture-based classes. However, involving students in a real software environment is a trendy alternative which fosters their engagement. Software engineering graduates are not appropriately prepared for applying their skills in a real software project. Thus, we focus on teaching and integrating teamwork-oriented skills in a real software development environment based on Scrum. In this work, we present Virtual Scrum (VS), a virtual reality environment that assists students with the running of a software project following the Scrum framework. VS supports artifacts needed for carrying out Scrum meetings and media-based tools to achieve permanent communication among Scrum members. A survey of students, who used the tool in a Software Engineering (SE) course, showed that VS is helpful to exercise Scrum practices.","palabras_clave":"Virtual Reality|Software Engineering|Scrum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88228,"idioma_id":4,"titulo":"New binary solid dispersion of indomethacin and croscarmellose sodium: physical characterization and in vitro dissolution enhancement","resumen":"Solid  dispersions  (SD x )  containing  Indomethacin  (IND),  a  poorly  water-soluble  drug,  and  the  disintegrant excipient  sodium  croscarmellose  (SC)  were  prepared  by  a  co-drying  method  and  characterized  by  Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and scanning electron  microscopy  (SEM).  An  FT-IR  analysis  performed  on  IND-SC  solid  dispersion  and  their  physical  mixtures indicated that IND does not interact with SC in the solid state. An analysis of the information produced by DSC, XRD, and SEM confirmed that the crystalline &#945;-form of IND was homogeneously incorporated into SD x . IND release from SD x  was significantly greater than that from its corresponding physical mixtures with the  high  homogeneous  molecular  dispersion  and  the  crystalline  modification  of  IND  appearing  to  be  the cause. This behavior may have a beneficial effect on the biopharmaceutical performance of this drug.","palabras_clave":"Solid dispersions|croscarmellose sodium |indomethacin|co-processed material"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88229,"idioma_id":4,"titulo":"Functional characterization of TLR4 + 3725 G\/C polymorphism and association with protection against overweight","resumen":"Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. We studied two polymorphisms (+3725G\/C and 11350G\/C) in the 3´ untranslated region (3´UTR) of the TLR4 gene that may alter its expression and their association with metabolic disorders related to systemic inflammation. We cloned the 3´UTR into a luciferase reporter system and compared wild-type 3´UTR (WT) and +3725C variant (MUT) constructs luciferase activities. MUT construct reduced the reporter gene activity by 30% compared to WT (P&#8202;=&#8202;0.0001). To evaluate the association between these polymorphisms with biochemical and clinical overweight related variables, we conducted a population cross-sectional study in 966 men of Argentine general population. Considering smoking as a confounding variable that causes systemic inflammation, we studied these possible effects in both, smokers and nonsmokers. The 11350G\/C polymorphism was not detected in our sample whereas the CC genotype of +3725 polymorphism was associated with lean subjects (p&#8202;=&#8202;0.011) and higher Adiponectin levels (p&#8202;=&#8202;0.021). Subjects without any NCEP\/ATP III MS component were associated with this genotype as well (p&#8202;=&#8202;0.001). These results were strengthened in nonsmokers, in which CC genotype was associated with lean subjects (p&#8202;=&#8202;0.003) and compared with G carriers showed significantly lower BMI (25.53 vs. 28.60 kg\/m2; p&#8202;=&#8202;0.023) and waist circumference (89.27 vs. 97.51 cm; p&#8202;=&#8202;0.025). None of these associations were found in smokers. These results showed that +3725C variant has a functional effect down-regulating gene expression and it could be considered as a predictive factor against overweight, particularly in nonsmokers. Considering the role of TLR4 in inflammation, these findings would suggest that the presence of +3725C variant could predict a lower prevalence of chronic metabolic disorders.","palabras_clave":"TLR4|Insulino resistencia|Sindrome metabolico|3' UTR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88230,"idioma_id":4,"titulo":"Middle- to late-Holocene environmental changes in Bajo de la Quinta, NE Patagonia, inferred by palynological records and their relation to human occupation","resumen":"The north Patagonian region between 38° and 42°S extends along the proximity of two major atmospheric circulation features in South America: the northern border of the southern westerly circulation belt, and the northeast trade wind circulation associated with the subtropical South Atlantic Anticyclone. The influence of this westerly wind system determines the annual and seasonal precipitation regimen in north Patagonia, while the influence of the South Atlantic Anticyclone is more pronounced towards the east. The changing strength of either of these circulation systems has had a strong influence on Holocene environmental change in the region. Palaeoenvironmental changes are inferred from a 500 cm long core from Bajo de la Quinta, (40°55´42'S, 64°20´19'W) by means of pollen, sediment and geomorphological analyses. A dry phase with westerly winds during the middle Holocene, at around 7000?6600 cal. yr BP, is indicated by xerophytic\/psammophytic vegetation and Patagonian steppe components. Between 6600 and 5200 cal. yr BP the pollen record reflects shrub steppe vegetation and low values of long distance transported pollen indicates little influence of the westerly winds. Between 5200 and 2900 cal. yr BP very arid conditions are indicated by high pollen values of Ephedra sp. and Nassauvia sp. and westerlies influenced by long distance pollen types such as Nothofagus sp. In the late Holocene (2900 cal. yr BP) the pollen record shows an increase in typical shrub taxa of the Monte and Espinal vegetation and low influence of long distance taxa. This may suggest a change to semi-arid conditions that persisted until the present, where the shrub steppe is the dominant vegetation. The environmental and geomorphological changes that occurred during the middle and late Holocene had influenced the space and resources used by hunter-gatherers of the area.","palabras_clave":"Palaeoenvironmental reconstruction |pollen analysis|human occupations |northeast Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88231,"idioma_id":5,"titulo":"Comunidades vegetales de la costa norte del Golfo San Matías, Río Negro, Argentina","resumen":"RESUMEN. Los ambientes costeros de dunas son ecosistemas complejos con una variación interna elevada y una  extensa zonación de la vegetación a lo largo de la línea de costa. La costa norte del Golfo San Matías presenta  un sistema de dunas donde la vegetación se distribuye en un gradiente desde la costa. Dicha vegetación está  caracterizada por comunidades psammófitas hasta estepas arbustivas xerófitas. Los objetivos de este trabajo  fueron 1) describir las principales comunidades vegetales del sitio de estudio, y 2) analizar la asociación  entre las comunidades vegetales y las unidades geomorfológicas. Se realizaron 16 censos de vegetación con  cuatro réplicas en cada unidad geomorfológica. El análisis de la vegetación realizado permitió describir tres  comunidades vegetales. La asociación entre la heterogeneidad florística y las cuatro unidades geomorfológicas  de Bajo de la Quinta se vincula principalmente con las características del sustrato.","palabras_clave":"vegetación costera|ambiente costero de duna|características geomorfológicas|Monte"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88232,"idioma_id":4,"titulo":"Modern pollen and vegetation relationships in Northeastern Patagonia (Golfo San Matías, Río Negro)","resumen":"The understanding of modern pollen is a critical component of palaeocological research. The pollen assemblages reflect general patterns in vegetation distribution; however, pollen representation is biased by several factors such as differences in pollen production, dispersal and preservation. Therefore, this relationship cannot be applied directly in pollen records of the past. The aim is to study the relationship between modern pollen and vegetation and to apply this new information on the interpretation of Holocene pollen records. Classification of the vegetation into groups corresponding to different geomorphological units was carried out by cluster analysis. Discriminant Analysis was applied on the surface samples to test if different vegetation types could be distinguished by their pollen assemblages. To evaluate the relationship between pollen assemblages and vegetation types, association (A), under-representation (U) and over-representation (O) indexes were calculated for all present taxa in both plant and pollen dataset. The main vegetation types are reflected in pollen assemblages but with greater differences in the proportions of Poaceae, Hyalis argentea, Chenopodiaceae, Asteraceae subf. Asteroideae and Larrea divaricata. Association and representation indexes provided information related to the production rate and pollen dispersal. This study helps to interpret Holocene vegetation and environmental changes from fossil pollen records of the study area.","palabras_clave":"pollen-vegetation relationship|northeastern Patagonia.|palynological richness,| association\/representation indexes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88233,"idioma_id":4,"titulo":"Performance of a multi-RCM ensemble for South Eastern South America","resumen":"The ability of four regional climate models to reproduce the present-day South American climate is examined with emphasis on La Plata Basin. Models were integrated for the period 1991-2000 with initial and lateral boundary conditions from ERA-40 Reanalysis. The ensemble sea level pressure, maximum and minimum temperatures and precipitation are evaluated in terms of seasonal means and extreme indices based on a percentile approach. Dispersion among the individual models and uncertainties when comparing the ensemble mean with different climatologies are also discussed. The ensemble mean is warmer than the observations in South Eastern South America (SESA), especially for minimum winter temperatures with errors increasing in magnitude towards the tails of the distributions. The ensemble mean reproduces the broad spatial pattern of precipitation, but overestimates the convective precipitation in the tropics and the orographic precipitation along the Andes and over the Brazilian Highlands, and underestimates the precipitation near the monsoon core region. The models overestimate the number of wet days and underestimate the daily intensity of rainfall for both seasons suggesting a premature triggering of convection. The skill of models to simulate the intensity of convective precipitation in summer in SESA and the variability associated with heavy precipitation events (the upper quartile daily precipitation) is far from satisfactory. Owing to the sparseness of the observing network, ensemble and observations uncertainties in seasonal means are comparable for some regions and seasons.","palabras_clave":"MULTI-RCM ENSEMBLE VALIDATION|REGIONAL CLIMATE MODELS|SOUTH AMERICA|SOUTH EASTERN SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88234,"idioma_id":4,"titulo":"Assessment of a multi-RCM ensemble for South America","resumen":"The ability of four regional climate models to reproduce the present-day   South American climate is examined with emphasis on La Plata Basin.   Models were integrated for the period 1991?2000 with initial and lateral   boundary conditions from ERA-40 Reanalysis. The ensemble sea level   pressure, maximum and minimum temperatures and precipitation are   evaluated in terms of seasonal means and extreme indices based on a   percentile approach. Dispersion among the individual models and   uncertainties when comparing the ensemble mean with different   climatologies are also discussed. The ensemble mean is warmer than the   observations in South Eastern South America (SESA), especially for   minimum winter temperatures with errors increasing in magnitude towards   the tails of the distributions. The ensemble mean reproduces the broad   spatial pattern of precipitation, but overestimates the convective   precipitation in the tropics and the orographic precipitation along the   Andes and over the Brazilian Highlands, and underestimates the   precipitation near the monsoon core region. The models overestimate the   number of wet days and underestimate the daily intensity of rainfall for   both seasons suggesting a premature triggering of convection. The skill   of models to simulate the intensity of convective precipitation in   summer in SESA and the variability associated with heavy precipitation   events (the upper quartile daily precipitation) is far from   satisfactory. Owing to the sparseness of the observing network, ensemble   and observations uncertainties in seasonal means are comparable for   some regions and seasons.","palabras_clave":"Regional Climate Models|Multi-RCM ensemble validation|South Eastern South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88235,"idioma_id":4,"titulo":"ALAS-1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice","resumen":"Porphyrias are diseases caused by partial deficiencies of haembiosynthesis enzymes. Acute porphyrias are characterized bya neuropsychiatric syndrome with intermittent induction ofhepatic ALAS1 (&#948;-aminolaevulinate synthase 1), the first andrate-limiting enzyme of the haem pathway. Acute porphyriaattacks are usually treated by the administration of glucose; itseffect is apparently related to its ability to inhibit ALAS1 bymodulating insulin plasma levels. It has been shown that insulinblunts hepatocyte ALAS1 induction, by disrupting the interactionof FOXO1 (forkhead box O1) and PGC-1&#945; (peroxisomeproliferator-activated receptor &#947; co-activator 1&#945;). We evaluatedthe expression of ALAS1 in a murine model of diabetes anddetermined the effects of the insulinomimetic vanadate on theenzyme regulation to evaluate its potential for the treatmentof acute porphyria attacks. Both ALAS1 mRNA and proteincontent were induced in diabetic animals, accompanied bydecreased Akt phosphorylation and increased nuclear FOXO1,PGC-1&#945; and FOXO1\u2013PGC-1&#945; complex levels.Vanadate reversedALAS1 induction, with a concomitant PI3K (phosphoinositide3-kinase)\/Akt pathway activation and subsequent reduction ofnuclear FOXO1, PGC-1&#945; and FOXO1\u2013PGC-1&#945; complex levels.These findings support the notion that the FOXO1\u2013PGC-1&#945;complex is involved in the control of ALAS1 expression andsuggest further that a vanadate-based therapy could be beneficialfor the treatment of acute porphyria attacks.Key words: acute porphyria, Akt, &#948;-aminolaevulinate synthase1 (ALAS1), forkhead box O1 (FOXO1), insulin, streptozotocin,vanadate.","palabras_clave":"FOXO-1|AKT|ALAS1|INSULINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88236,"idioma_id":4,"titulo":"Iron and holotransferrin induce cAMP-dependent differentiation of Schwann cells","resumen":"The differentiation of myelin-forming Schwann cells (SC) is completed with the appearance of myelinproteins MBP and P0 and a concomitant downregulation of markers GFAP and p75NTR, which areexpressed by immature and adult non-myelin-forming SC. We have previously demonstrated that holotransferrin(hTf) can prevent SC dedifferentiation in culture (Salis et al., 2002), while apotransferrin (aTf)cannot. As a consequence, we used pure cultured SC and submitted them to serum deprivation in order topromote dedifferentiation and evaluate the prodifferentiating ability of ferric ammonium citrate (FAC)through the expression of MBP, P0, p75NTR and c-myc. The levels of cAMP, CREB and p-CREB were alsomeasured. Results show that Fe3+, either in its free form or as hTf, can prevent the dedifferentiation promotedby serum withdrawal.Both FAC and hTf were proven to promote differentiation, probably through the increase in cAMP levelsand CREB phosphorylation, as well as levels of reactive oxygen species. This effect was inhibited by deferroxamine(Dfx, an iron chelator), H9 (a cAMP-PKA antagonist) and N-acetylcysteine (NAC, a powerfulantioxidant).","palabras_clave":"Schwann cells|Holotransferrin|cAMP|CREB"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88237,"idioma_id":4,"titulo":"Semen promotes the differentiation of tolerogenic dendritic cells","resumen":"Seminal plasma is not just a carrier for spermatozoa. It contains high concentrations of cytokines, chemokines, and other biological compounds that are able to exert potent effects on the immune system of the receptive partner. Previous studies have shown that semen induces an acute inflammatory response at the female genital mucosa after coitus. Moreover, it induces regulatory mechanisms that allow the fetus (a semiallograft) to grow and develop in the uterus. The mechanisms underlying these regulatory mechanisms, however, are poorly understood. In this study, we show that seminal plasma redirects the differentiation of human dendritic cells (DCs) toward a regulatory profile. DCs differentiated from human monocytes in the presence of high dilutions of seminal plasma did not express CD1a but showed high levels of CD14. They were unable to develop a fully mature phenotype in response to LPS, TNF-&#945;, CD40L, Pam2CSK4 (TLR2\/6 agonist), or Pam3CSK4 (TLR1\/2 agonist). Upon activation, they produced low amounts of the inflammatory cytokines IL-12p70, IL-1&#946;, TNF-&#945;, and IL-6, but expressed a high ability to produce IL-10 and TGF-&#946;. Inhibition of the PG receptors E-prostanoid receptors 2 and 4 prevented the tolerogenic effect induced by seminal plasma on the phenotype and function of DCs, suggesting that E-series PGs play a major role. By promoting a tolerogenic profile in DCs, seminal plasma might favor fertility, but might also compromise the capacity of the receptive partner to mount an effective immune response against sexually transmitted pathogens.","palabras_clave":"SEMEN|DENDRITIC CELL|SPERM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88238,"idioma_id":4,"titulo":"PVD TiN and CrN Coated Austempered Ductile Iron: Analysis of Processing Parameters Influence on Coating Characteristics and Substrate Microstructure","resumen":"This work studies the influence of the PVD processing parameters on the characteristics of TiN and CrN coatings deposited on ADI substrates, austempered at 360ºC, with different nodule counts and surface roughnesses. Coatings were applied by arc ion plating using an industrial reactor and different sets of parameters, with BIAS voltages, arc currents, chamber pressures and substrate temperatures varying from -100 to -250 V, 60 to 65 A, 0.7 to 2.8 Pa and 280 to 450ºC, respectively. The effect of the different depositions conditions on the substrates microstructure was also analyzed. The existing phases, preferred orientation, surface topography, film thickness, hardness and adhesion of each coating were determined. The retained austenite content and hardness of each substrate were computed before and after coating deposition.The results obtained indicate that the different deposition conditions and coating materials evaluated do not generate significant changes neither in the resulting topography nor in the coating adhesion, which can be related to indices between HF1 and HF2. Coating adhesion was not affected by different substrate roughnesses. The combined reduction of BIAS voltage, arc current and chamber pressure leads to a decrease of TiN growth rate and hardness, while high substrate temperatures promotes an increase in TiN and CrN growth rates. Substrate temperatures around 300ºC with deposition times of up to 240 min do not promote noticeable changes on the ausferritic microstructure,while temperatures of 400ºC and above translate into a clear microstructural deterioration, even for short deposition times.","palabras_clave":"AUSTEMPERED DUCTILE IRON|TiN|CrN|PVD PROCESSING PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88239,"idioma_id":4,"titulo":"Kinetic studies on the anaerobic degradation of soluble and particulate matter in potato wastewater","resumen":"The anaerobic degradation of particulate-containing potato processing   wastewater using a mixed culture from an industrial anaerobic wastewater   treatment plant as inoculum was characterised and modelled. Anaerobic   digestion is being increasingly used for wastewater treatment,   particularly those which contain high levels of biodegradable matter   such as potato processing effluents. A major prerequisite for its proper   modelling is a reliable wastewater characterisation with a proper   discrimination of the chemical oxygen demand (COD) fractions. These   wastewaters contain both soluble (S) and particulate (X)   organic load that are assimilated by microorganisms at different rates.   Furthermore, these wastewaters generally contain both solid (XI) and soluble (SI)   inert to anaerobic degradation fractions. In this work, a procedure to   determine the COD fractions of potato wastewater is developed. For the   wastewater studied, the initial fraction of inert particulate organic   matter (xXI) was negligible, while the initial fraction of inert soluble organic matter (xSI)   was 20.94% ± 1.65. A model with first-order serial-parallel reactions   system was developed for biodegradable fractions. This model has   demonstrated its capability to predict the behaviour of the system and   can be used for further research work or more complex reactor design.","palabras_clave":"Anaerobic digestion|wastewater treatment|microbial biocatalysis|kinetic model|COD fraction|particulate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88240,"idioma_id":4,"titulo":"Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines","resumen":"AbstractMammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during theirtransit through the female genital tract in a process known as capacitation. The mammalian oviduct acts as a functionalsperm reservoir providing a suitable environment that allows the maintenance of sperm fertilization competence untilovulation occurs. After ovulation, spermatozoa are gradually released from the oviductal reservoir in the caudal isthmus andascend to the site of fertilization. Capacitating-related changes in sperm plasma membrane seem to be responsible forsperm release from oviductal epithelium. Anandamide is a lipid mediator that participates in the regulation of severalfemale and male reproductive functions. Previously we have demonstrated that anandamide was capable to releasespermatozoa from oviductal epithelia by induction of sperm capacitation in bovines. In the present work we studiedwhether anandamide might exert its effect by activating the nitric oxide (NO) pathway since this molecule has beendescribed as a capacitating agent in spermatozoa from different species. First, we demonstrated that 1 mM NOC-18, a NOdonor, and 10 mM L-Arginine, NO synthase substrate, induced the release of spermatozoa from the oviductal epithelia.Then, we observed that the anandamide effect on sperm oviduct interaction was reversed by the addition of 1 mM L-NAME,a NO synthase inhibitor, or 30 mg\/ml Hemoglobin, a NO scavenger. We also demonstrated that the induction of bull spermcapacitation by nanomolar concentrations of R(+)-methanandamide or anandamide was inhibited by adding L-NAME orHemoglobin. To study whether anandamide is able to produce NO, we measured this compound in both sperm andoviductal cells. We observed that anandamide increased the levels of NO in spermatozoa, but not in oviductal cells. Thesefindings suggest that anandamide regulates the sperm release from oviductal epithelia probably by activating the NOpathway during sperm capacitation","palabras_clave":"ANANDAMIDE|CAPACITATION|SPERM|BOVINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88241,"idioma_id":4,"titulo":"Interaction between Lysophosphatidic Acid, Prostaglandins and the       Endocannabinoid System during the Window of Implantation in the Rat Uterus","resumen":"Bioactive lipid molecules as lysophosphatidic acid (LPA), prostaglandins (PG) and endocannabinoids are importantmediators of embryo implantation. Based on previous published data we became interested in studying the interactionbetween these three groups of lipid derivatives in the rat uterus during the window of implantation. Thus, we adopteda pharmacological approach in vitro using LPA, DGPP (a selective antagonist of LPA3, an LPA receptor), endocannabinoids?receptor selective antagonists (AM251 and AM630) and non selective (indomethacin) and selective (NS-398) inhibitors ofcyclooxygenase-1 and 2 enzymes. Cyclooxygenase isoforms participate in prostaglandins? synthesis. The incubation of theuterus from rats pregnant on day 5 of gestation (implantation window) with LPA augmented the activity and the expressionof fatty acid amide hydrolase, the main enzyme involved in the degradation of endocannabinoids in the rodent uteri,suggesting that LPA decreased endocannabinoids? levels during embryo implantation. It has been reported that highendocannabinoids are deleterious for implantation. Also, LPA increased PGE2 production and cyclooxygenase-2 expression.The incubation of LPA with indomethacin or NS-398 reversed the increment in PGE2 production, suggesting thatcyclooxygenase-2 was the isoform involved in LPA effect. PGs are important mediators of decidualization andvascularization at the implantation sites. All these effects were mediated by LPA3, as the incubation with DGPP completelyreversed LPA stimulatory actions. Besides, we also observed that endocannabinoids mediated the stimulatory effect of LPAon cyclooxygenase-2 derived PGE2 production, as the incubation of LPA with AM251 or AM630 completely reversed LPAeffect. Also, LPA augmented via LPA3 decidualization and vascularization markers. Overall, the results presented heredemonstrate the participation of LPA3 in the process of implantation through the interaction with other groups of lipidmolecules, prostaglandins and endocannabinoids, which prepare the uterine milieu for embryo invasion during the windowof implantation.","palabras_clave":"LYSOFOSPHATIDIC ACID|ENDOCANNABINOID SYSTEM|IMPLANTATION|RAT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88242,"idioma_id":4,"titulo":"The functional interaction between acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target","resumen":"    The acyl-CoA synthetase 4  (ACSL4), which belongs to a five-member family of enzymes that esterifies  mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and  hepatocellular carcinoma. The transfection of MCF-7 cells with ACSL4 cDNA transforms  the cells into a highly aggressive phenotype and controls both lipooxygenase-5  (LOX-5) and cyclooxygenase-2 (COX-2) metabolism of AA, suggesting a causal role  of ACSL4 in tumorigenesis. We hypothesized that ACSL4, LOX-5 and COX-2 could  constitute potential therapeutic targets for the control of tumor growth.  Therefore, the aim of this study was to use a xenograft model of breast cancer  to confirm the effect of ACSL4 overexpression on tumor growth in vivo, and to determine whether a  combinatorial inhibition of the ACSL4-LOX-COX-2 pathway affects tumor growth in vivo. The first novel finding is that stable transfection of ACSL4 of MCF-7  cells resulted in development of tumors when injected into nude mice. The tumors presented marked nuclear  polymorphism, high mitotic index  and low expression of estrogen and progesterone receptor. Tumor xenograft development measured in animals that received doxycycline resulted  in tumor growth inhibition. These results demonstrated the transformational capacity of ACSL4 overexpression. We  subsequently examined the effect of a combination of inhibitors of ACSL4, LOX-5  and COX-2 on MDA-MB-231 tumor xenografts. This treatment markedly reduced tumor  growth in doses of these inhibitors that were otherwise ineffective when used  alone, indicating a synergistic effect of the compounds. Our results suggest  that these enzymes interact functionally and form an integrated system that  operates in a concerted manner to regulate tumor growth and consequently may be  potential therapeutic targets for the control of tumor growth as well as the  proliferation and metastatic potential of cancer cells.","palabras_clave":"TUMOR GROWTH|THERAPY|ACYL- COA SYNTHETASE|4, 5-LIPOOXYGENASE|CYCLOOXYGENASE-2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88243,"idioma_id":4,"titulo":"Lack of cytochrome c in Arabidopsis decreases stability of Complex IV and modifies redox metabolism without affecting Complexes I and III","resumen":"We studied the role of cytochrome c (CYTc), which mediates electrontransfer between Complexes III and IV, in cellular events related withmitochondrial respiration, plant development and redox homeostasis. We analyzedsingle and double homozygous mutants in both CYTc-encoding genes from Arabidopsis: CYTC-1 and CYTC-2. Whileindividual mutants were similar to wild-type, knock-out of both genes producedan arrest of embryo development, showing that CYTc function is essential atearly stages of plant development. Mutants in which CYTc levels were extremelyreduced respective to wild-type had smaller rosettes with a pronounced decreasein parenchymatic cell size and an overall delay in development. Mitochondriafrom these mutants had lower respiration rates and a relativeincrease in alternativerespiration. Furthermore, the decrease in CYTc severely affected the activityand the amount of Complex IV, without affecting Complexes I and III. Reactiveoxygen species levels were reduced in these mutants, which showed induction ofgenes encoding antioxidant enzymes. Ascorbic acid levels were not affected,suggesting that a small amount of CYTc is enough to support its normal synthesis.We postulate that, in addition to its role as an electron carrier betweenComplexes III and IV, CYTc influences Complex IV levels in plants, probablyreflecting a role of this protein in Complex IV stability. This double functionof CYTc most likely explains why it is essential for plant survival.","palabras_clave":"citocromo c|mitocondria|respiracion|Arabidopsis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88244,"idioma_id":4,"titulo":"Determinants of the DNA binding specificity of class I and class II TCP transcription factors","resumen":"      TCP proteins constitute a family of plant  transcription factors with more than 20 members in angiosperms. They can be divided  in two classes based on sequence homology and the presence of an insertion  within the basic region of the TCP DNA binding and dimerization domain. Here,  we describe binding site selection studies with the class I protein TCP16, showing  that its DNA binding preferences are similar to those of class II proteins.  Through sequence comparison and the analysis of mutants and chimeras of TCP16,  TCP20 (class I) and TCP4 (class II), we established that the identity of  residue 11 of the class I TCP domain or the equivalent residue 15 of the class  II domain, whether it is Gly or Asp, determines a preference for a class I or a  class II sequence, respectively. Footprinting analysis indicated that specific DNA  contacts related with these preferences are established with one of the strands  of DNA. The dimerization motif also influences the selectivity of the proteins  towards class I and class II sequences and determines a requirement of an  extended basic region in proteins with Asp15. We postulate that diferences in  orientation of base-contacting residues brought about by the presence of either  Gly or Asp are responsible for the binding site preferences of TCP proteins. Expression  of repressor forms of TCP16 with Asp11 or Gly11 differently affects leaf  development. TCP16-like proteins with Asp11 in the TCP domain arose in rosids  and may be related with developmental characteristics of this lineage of  eudicots.","palabras_clave":"TCP domain|Arabidopsis|development|transcription factor"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88245,"idioma_id":4,"titulo":"Delta subclass HD-Zip proteins and a B-3 AP2\/ERF transcription factor interact with promoter elements required for expression of the Arabidopsis cytochrome c oxidase 5b-1 gene","resumen":"We have identified transcription factors thatinteract with a promoter region involved in expression ofthe Arabidopsis thaliana COX5b-1 gene, which encodes anisoform of the cytochrome c oxidase zinc binding subunit.Elements with the core sequence ATCATT, involved ininduction by sugars, are recognized both in vitro and inone-hybrid assays in yeast by HD-Zip proteins fromthe delta subclass and, though less efficiently, by the trihelixtranscription factor GT-3b. DistalB-like elements(CCACTTG), required for induction by abscisic acid(ABA), interact with ESE1, a member of the B-3 subgroupof AP2\/ERF transcription factors. The HD-Zip proteinAthb-21 and ESE1 are able to interact in yeast two-hybridassays with the ABA responsive element binding factorAREB2\/ABF4, which binds to a G-box absolutely requiredfor expression of the COX5b-1 gene. Overexpression of theidentified transcription factors in plants produces anincrease in COX5b-1 transcript levels. Moreover, thesefactors are able to induce the expression of a reporter genelocated in plants under the control of the relevant COX5b-1promoter regions required for expression. Analysis ofpromoter regions of COX5b genes from different plantspecies suggests that the identified transcription factorswere recruited for the regulation of COX5b gene expressionat different stages during the evolution of dicot plants.","palabras_clave":"ARABIDOPSIS THALIANA|CYTOCHROME C OXIDASE|GENE EXPRESSION|HD-ZIP PROTEIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88246,"idioma_id":4,"titulo":"In vitro plant regeneration from cotyledonary nodes of Recombinant Inbred Lines of Lentil","resumen":"An efficient and reproducible in vitro regeneration protocol for lentil was developed. For shoot regeneration, cotyledonary node explants of ten elite genotypes were cultured in an inverted orientation on different shoot regeneration media that consisted of Murashige and Skoog (MS) medium supplemented with 1 mg L&#8722;1 6-benzylaminopurine (BAP) (M1), 1 mg L&#8722;1 BAP + 0.45 mg L&#8722;1 indole-3-acetic acid (IAA) (M2), and 2 mg L&#8722;1 BAP (M3). High percentages of shoot regeneration ranging from 80 to 100% on M1 and M3 media and from 50 to 100% on M2 medium were induced. M1 was the most efficient shoot regeneration medium for most genotypes tested. For rooting, in vitro and in vitro?in vivo methods were used. Low and variable rooting percentages ranging from 0 to 45% were recorded with in vitro?in vivo method. Efficiency of rooting on in vitro medium varied depending on the medium in which shoots had been previously regenerated and the genotype tested. When M1 medium was used, high rooting percentages (over 40%) for most genotypes except for microsperma genotypes were found. When the 10 genotypeswere screened for good regeneration performance using M1 medium, 2 main clusters and 3&nbsp; subgroups within one of the clusters were formed based on similarities respect of the number of regenerated shoots per explant and rooting percentages. Subgroup 1 composed by A1146 genotype produced the highest number of shoots per explant (6.17 shoots) and a high rooting percentage (60%) so was selected for further transformation and use as a potential commercial variety.","palabras_clave":"Cotyledonary node |In vitro e in vivo rooting|Lentil |Shoot regeneration"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88247,"idioma_id":4,"titulo":"Differential bone survivorship and ontogenetic development in guanaco (Lama guanicoe)","resumen":"                                This paper presents the results of a taphonomic research program conducted during  the  last  five  years.  The  main  objective  of  this  program  was  to  investigate differential survivorship in guanaco (Lama guanicoe) bones taking into account the ontogenetic development of this species and the densitometric characteristics of its skeletal parts. In the first place, density analysis was carried out from selected bones of modern individuals corresponding to different age classes. Secondly, two experimental designs were conducted to explore the responses of bones from animals of different ages to weathering and fluvial transport. The former is a long term experiment that intends to examine the deterioration of skeletal elements from a newborn, a juvenile and an adult modern guanaco exposed to sub-aerial weathering under controlled conditions. The second experiment examined the hydrodynamic sorting of dry and wet skeletal elements from a newborn, a juvenile and an adult modern guanaco in an artificial flume under controlled current velocities (15 cm\/s and 30 cm\/s). The main result of this research program indicates that immature bones have higher hydric transport potential and they weathered at a faster rate. We proposed that this differential bone behavior is partially related to their structural density as it evidenced by our density analysis. These results alert on the age-related biases in zooarchaeological assemblages affected by taphonomic processes. ","palabras_clave":"MORTALITY PROFILES|BONE MINERAL DENSITY|FLUVIAL TRANSPORT|WEATHERING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88248,"idioma_id":5,"titulo":"Estimación de la edad de muerte de guanacos juveniles a partir de las dimensiones de los huesos largos n o fusionados. Estructura de edad y estacionalidad en el Campo Volcánico de Pali Aike (sitio Orejas de Burro 1)","resumen":"Lama guanicoe (guanaco) is the best represented land mammal in continental archaeological hunter-gatherer sites during  the Holocene in Patagonia and the Pampas of South America. The main objective of this paper is to develop a model  to estimate the age of immature guanacos by the length of their long bones, which will help discriminate age in young  bone specimens of this species. The individuals studied belong to a comparative collection of modern guanaco specimens  from the Cinco Chañares locality, Rio Negro province, Northern Patagonia, Argentina. The correlation analyses  show that the association between greatest length (GL) and age was very high for all unfused long bones, with highly  significant probability levels (P < 0.01). This allowed us to develop four predictive models to estimate the age-at-death  for juvenile guanacos using a simple regression analysis. The use of new methodological tools that improve knowledge  of age structure in fossil assemblages of Lama guanicoe significantly contribute to the discussion and interpretation of  prey selection strategies and seasonality of guanaco exploitation by Patagonian and Pampean hunter-gatherer groups  during the Holocene.","palabras_clave":"GUANACOS JUVENILES|ESTIMACIÓN DE LA EDAD|OSTEOMETRÍA|ESTACIONALIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88249,"idioma_id":4,"titulo":"Effects of  Clostridium perfringens alpha and epsilon toxins in the bovine gut.","resumen":"Clostridium perfringens alpha and epsilon toxins produce enterotoxaemia in sheep and goats. However, the information regarding the pathophysiology of alpha and epsilon toxins in the bovine intestine is still scanty. In this study, intestinal loops were performed in the ileum and colon of three one-week-old Holstein and two four-week-old crossbreed calves. Laparotomy was performed in all calves under anaesthesia and four loops -three cm long- were performed in the small and large intestines. For both intestines, loops were inoculated with alpha or epsilon toxins. Tissue samples from all loops were obtained and processed for routine histology and for transmission electron microscopy. Congestion was observed in toxin treated loops. Fluid accumulation in the gut lumen was prominent in all treated loops, but in epsilon treated ones the mucous was also haemorrhagic. The histology revealed large amount of exfoliated epithelial cells in the lumen of alpha toxin treated loops and severe haemorrhage was observed in the lamina propria of epsilon toxin treated colonic loops. Despite some necrotic exfoliated enterocytes, no ultraestructural changes were observed in alpha toxin treated loops, though with epsilon toxin the loops exhibited dilation of the intercellular space in the mucosa of both, small and large intestines. These observations indicate that both, alpha and epsilon toxins can alter the intestinal barrier, in calves and are pathogenic for this species.","palabras_clave":"Clostridium perfringens|toxins|bovine|intestine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88250,"idioma_id":4,"titulo":"Detection of Shiga toxin producing Escherichia coli by sandwich enzyme linked immunosorbentassay using chicken egg yolk IgY antibodies","resumen":"&nbsp;Enterohemorrhagic Escherichia coli (EHEC), a subset of Shiga toxin producing E. coli (STEC) is associated with a spectrum of diseases that includes diarrhea, hemorrhagic colitis and a life-threatening hemolytic-uremic syndrome (HUS). Regardless of serotype, Shiga toxins (Stx1 and\/or Stx2) are uniformly expressed by all EHEC, and so exploitable targets for laboratory diagnosis of these pathogens. In this study, a sandwich ELISA for determination of Shiga toxin (Stx) was developed using anti-Stx2B subunit antibodies and its performance was compared with that of the Vero cell assay and a commercial immunoassay kit. Chicken IgY was used as capture antibody and a HRP-conjugated rabbit IgG as the detection antibody. The anti-Stx2B IgY was harvested from eggs laid by hens immunized with a recombinant protein fragment. Several parameters were tested in order to optimize the sandwich ELISA assay, including concentration of antibodies, type and concentration of blocking agent, and incubation temperatures. Supernatants from 42 STEC strains of different serotypes and stx variants, including stx2EDL933, stx2vha, stx2vhb, stx2g, stx1EDL933, and stx1d were tested. All Stx variants were detected by the sandwich ELISA, with a detection limit of 115 ng\/ml Stx2. Twenty three strains negative for stx genes, including different bacteria species, showed no activity in Vero cell assay and produced negative results in ELISA, except for two strains. Our results show that anti-Stx2B IgY sandwich ELISA could be used in routine diagnosis as a rapid, specific and economic method for detection of Shiga toxin-producing E. coli.","palabras_clave":"Escherichia coli | Shigatoxin|ELISA|IgY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88251,"idioma_id":4,"titulo":"Fresh biomass production and partitioning of aboveground growth in the three botanical varieties of Cynara cardunculus L","resumen":"Fourteen accessions of Cynara cardunculus were compared with the aim to evaluate the fresh biomass production  and its partition, aiming at its potential use for industrial purposes. At anthesis stage, when plants  have the maximum vegetative development, stalks, leaves and capitula were weighed separately.  The  percentage of dry matter per gram of fresh biomass was also calculated. The &#64257;rst capitulum components of each plant: bracts, &#64258;owers and remnant receptacle were also weighed separately. The total fresh  biomass ranged between 1188 and 3235 g\/plant, with variable values within each botanical variety, whereas the partition of the aboveground biomass was strongly affected by botanical variety. In both cardoons varieties, the percentage of dry matter   ranged between 30 and 35% for all components aboveground biomass, whereas in globe artichoke values ranged between 20% for capitula and 40% for leaves. Regarding  capitula components, receptacle weight was of greatest importance in globe artichoke and cultivated cardoon. In wild cardoon &#64258;owers weight was more important than the other components. Results suggest that  Cynara cardunculus var. scolymus and C. cardundulus var. cardunculus, might be considered as double purpose crops if after the capitula (in globe artichoke) or leaves (in cardoon) harvest, the fresh matter  remaining is arti&#64257;cially dried and cut. On the other hand, Cynara cardunculus var. sylvestris, might be incorporated into the culture system as an industry or energy crop due the low inputs management that it requires, its adaptability to the local conditions and its aboveground biomass production.","palabras_clave":"BIOMASS|DRY MATTER|FRESH MATTER|BIOMASS PARTITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88252,"idioma_id":4,"titulo":"A rapid method to increase F1 plants number in breeding pea programs (Pisum sativum L.)","resumen":"This study surveyed a rapid, efficient and reproducible protocol for in vitro shoot regeneration and rooting of seeds by different concentration of BA. Due to optimization of shoot regeneration, two media including of MS and modified MS (MS salts with B5 vitamins), and different concentration of BA (25, 50 and 75ìM) in five genotypes were used. The results showed that modified MS (B5 vitamins + 25 ìM of BA) is a suitable medium for in vitro shoot regeneration of pea. 38 of 76 hybrids combinations (19 accessions x 4 testers) produced fewer seeds than the rest. Seeds of these hybrids were transferred into selected medium to produce shoots that were used for root induction on MS medium supplemented with -naphthalene-acetic acid. In any case, it was possible to develop elongated shoots from all hybrids genotypes in different values. The procedure outlined here can be used in breeding programs in pea, and will allow working with a greater&nbsp; number of plants when the crosses are less efficient in seed production.","palabras_clave":"MICRO-PROPAGATION|GROWTH REGULATORS|SEEDS CULTURE|MULTIPLE SHOOTING|IN VITRO CULTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88253,"idioma_id":4,"titulo":"Isolation and characterization of an H9N2 influenza virus isolated in Argentina","resumen":"As part of our ongoing efforts on animal influenza surveillance in Argentina, an H9N2 virus was isolated from a wild aquatic bird (Netta peposaca), A\/rosy-billed pochard\/Argentina\/CIP051-559\/2007 (H9N2) \u2013 herein referred to as 559\/H9N2. Due to the important role that H9N2 viruses play in the ecology of influenza in nature, the 559\/H9N2 isolate was characterized molecularly and biologically. Phylogenetic analysis of the HA gene revealed that the 559\/H9N2 virus maintained an independent evolutionary pathway and shared a sister-group relationship with North American viruses, suggesting a common ancestor. The rest of the genome segments clustered with viruses from South America. Experimental inoculation of the 559\/H9N2 in chickens and quail revealed efficient replication and transmission only in quail. Our results add to the notion of the unique evolutionary trend of avian influenza viruses in South America. Our study increases our understanding of H9N2 viruses in nature and emphasizes the importance of expanding animal influenza surveillance efforts to better define the ecology of influenza viruses at a global scale.","palabras_clave":"Low pathogenic avian influenza|Ecology|H9N2|Transmission|South America|Argentina|Chicken|Quail|Wild bird|Rosy-billed pochard"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88254,"idioma_id":4,"titulo":"RIM, Munc13, and Rab3A interplay in acrosomal exocytosis","resumen":"Exocytosis is a highly regulated, multistage process consisting of multiple functionally definable stages, including recruitment, targeting, tethering, priming, and docking of secretory vesicles with the plasma membrane, followed by calcium-triggered membrane fusion. The acrosome reaction of spermatozoa is a complex, calcium-dependent regulated exocytosis. Fusion at multiple sites between the outer acrosomal membrane and the cell membrane causes the release of the acrosomal contents and the loss of the membranes surrounding the acrosome. Not much is known about the molecules that mediate membrane docking in this particular fusion model. In neurons, the formation of the ternary RIM\/Munc13\/Rab3A complex has been suggested as a critical component of synaptic vesicles docking. Previously, we demonstrated that Rab3A localizes to the acrosomal region in human sperm, stimulates acrosomal exocytosis, and participates in an early stage during membrane fusion. Here, we report that RIM and Munc13 are also present in human sperm and localize to the acrosomal region. Like Rab3A, RIM and Munc13 participate in a prefusion step before the efflux of intra-acrosomal calcium. By means of a functional assay using antibodies and recombinant proteins, we show that RIM, Munc13 and Rab3A interplay during acrosomal exocytosis. Finally, we report by electron transmission microscopy that sequestering RIM and Rab3A alters the docking of the acrosomal membrane to the plasma membrane during calcium-activated acrosomal exocytosis. Our results suggest that the RIM\/Munc13\/Rab3 A complex participates in acrosomal exocytosis and that RIM and Rab3A have central roles in membrane docking.    ","palabras_clave":"RIM|MUNC13|RAB3A|ACROSOME REACTION |MEMBRANE DOCKING  |HUMAN SPERM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88255,"idioma_id":4,"titulo":"Recording and sorting live human sperm undergoing acrosome reaction","resumen":"OBJECTIVE: To develop and evaluate a method to detect acrosome reaction in live human sperm  DESIGN: Prospective study  SETTING: Basic research laboratory  PATIENT(s): Human semen samples with normal parameters obtained from healthy donors  INTERVENTIONS: Acrosome reaction assays  MAIN OUTOME: Fluorescence assessment of acrosome reaction   RESULTS: Evaluating acrosomal exocytosis in live human sperm is challenging. In this study, we report that in reacting sperm, Pisum sativum agglutinin conjugated to fluorescein isothiocyanate rapidly permeates into the acrosome when fusion pores open and stabilizes the acrosomal matrix, preventing the dispersal of the granule contents.  CONCLUSIONS : Fluorescent Pisum sativum agglutinin can be used to visualize acrosome reaction in real time, to determine the percentage of sperm undergoing exocytosis upon stimulation, and to separate the population of reacting sperm by flow cytometry.","palabras_clave":"acrosome reaction|human sperm|Pisum sativum agglutinin|flow cytometry acrosomal matrix"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88256,"idioma_id":4,"titulo":"Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate","resumen":"Acrosomal exocytosis involves a massive fusion between the outer acrosomal and the plasma membranes of the spermatozoon triggered by stimuli that open calcium channels at the plasma membrane. Diacylglycerol has been implicated in the activation of these calcium channels. Here we report that this lipid promotes the efflux of intraacrosomal calcium and triggers exocytosis in permeabilized human sperm, implying that diacylglycerol activates events downstream of the opening of plasma membrane channels. Furthermore, we show that calcium and diacylglycerol converge in a signaling pathway leading to the production of phosphatidylinositol 4,5-bisphosphate (PIP(2)). Addition of diacylglycerol promotes the PKC-dependent activation of PLD1. Rescue experiments adding phosphatidic acid or PIP(2) and direct measurement of lipid production suggest that both PKC and PLD1 promote PIP(2) synthesis. Inhibition of different steps of the pathway was reverted by  adenophostin, an agonist of IP(3)-sensitive calcium channels, indicating that PIP(2) is necessary to keep these channels opened. However, phosphatidic acid, PIP(2), or adenophostin could not trigger exocytosis by themselves, indicating that diacylglycerol must also activate another factor. We found that diacylglycerol and phorbol ester stimulate the accumulation of the GTP-bound form of Rab3A. Together our results indicate that diacylglycerol promotes acrosomal exocytosis by i) maintaining high levels of IP(3) - an effect that depends on a  positive feedback loop leading to the production of PIP(2) - and ii) stimulating the activation of Rab3A, which in turn initiates a cascade of protein interactions leading to the assembly of SNARE complexes and membrane fusion.","palabras_clave":"acrosomal exocytosis|phosphatidylinositol 4,5-bisphosphate|diacylglycerol|phosphatidic acid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88257,"idioma_id":4,"titulo":"Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis","resumen":"                      Two  'secretory Rabs', Rab3 and Rab27, regulate late steps during  dense-core vesicle exocytosis in neuroendocrine cells. Sperm contain a single,  large dense-core granule that is released by regulated exocytosis (termed the  acrosome reaction) during fertilization or upon exposure to inducers in vitro.  Sperm exocytosis utilizes the same fusion machinery as neurons and  neuroendocrine cells with an additional requirement for active Rab3. Here, we  show that Rab27 is also required for the acrosome reaction, since inducers were  unable to elicit exocytosis when streptolysin O-permeabilized human sperm were  loaded with inhibitory anti-Rab27 antibodies or the Rab27-GTP binding domain of  the effector Slac2-b. The levels of GTP-bound Rab27 increased upon initiation  of exocytosis, as did the proportion of GTP-bound Rab3A. We have developed a  fluorescence microscopy-based method by which we can detect endogenous Rab3A-GTP  and Rab27-GTP in the acrosomal region of human sperm. Challenging with an  inducer increased the population of cells exhibiting GTP-bound Rabs in this  subcellular domain. Interestingly, introducing recombinant Rab27A loaded with  GTP-&#947;-S into sperm elicited a remarkable increase in the number of cells  evincing GTP-bound Rab3A. In the converse condition, recombinant Rab3A did not  modify the percentage of Rab27-GTP-containing cells. Furthermore, Rab27A-GTP  recruited a Rab3 GEF activity. Our findings suggest that Rab27\/Rab3A constitute  a novel Rab GEF cascade, the first ever described in dense-core vesicle  exocytosis.","palabras_clave":"RAB27|RAB3|SPERM|EXOCYTOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88258,"idioma_id":4,"titulo":"In vitro propagation of pink lapacho: response surface methodology and factorial analysis for optimisation of medium components","resumen":"Handroanthus impetiginosus, pink lapacho, is a timber, ornamental, and medicinal tree. Experiments on the in vitro propagation of H. impetiginosus were conducted using nodal segments cultivated in both Murashige and Skoog salts with Gamborg vitamins (MSG) and Woody Plant Medium (WPM) with different concentrations of 6-benzylaminopurine (BA) and indole butyric acid (IBA). Morphogenic responses were differentially affected by salt compositions and their interactions with plant growth regulators in each micropropagation stage. According to response surface analysis, the optimum multiplication rate with 1&#8201;&#956;M IBA ranged from 16.7 to 21.3&#8201;&#956;M BA in WPM, and the inhibitors of endogenous auxins could increase multiplication rates. A pulse with 50&#8201;&#956;M IBA in 1 \/ 2 MSG produced 83% rooting with 3.2 roots per shoots and higher fresh and dry weights of shoots and roots. In the acclimatisation stage, 50% of plants survived after 1 year. This methodology optimised the culture media for the in vitro propagation of the H. impetiginosus clonal pool and could be applied to related species, several of which are categorised as vulnerable on the International Union for the Conservation of Nature Red List.","palabras_clave":"NUTRIOTIONAL COMPONETS|PINK LAPACHO|RESPONSE SURFECE METHODOLOGY|TISSUE CULTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88259,"idioma_id":4,"titulo":"Response of the fruit fly parasitoid Diachasmimorpha longicaudata to host and host-habitat volatile cues","resumen":"Chemical information is crucial to insect parasitoids for successful host location. Here, we evaluated the innate response of Diachasmimorpha longicaudata (Ashmead) (Hymenoptera: Braconidae), a fruit fly larval parasitoid, to cues from host and host habitat (i.e., fruit infested with host larvae). We first assessed the preference of female parasitoids between oranges infested with Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) and non-infested fruit. Females were highly attracted towards infested oranges on the basis of volatile chemical cues. After this initial experiment, we aimed at revealing the potential sources of volatile cues present in an infested fruit. To this end, we considered five potential sources: (1) punctured fruit; (2) fly feeding, frass, or host-marking pheromone deposited on the orange surface; (3) larval activity inside the fruit; (4) the larvae themselves; and (5) fungi associated with infestation of oranges. Habitat cues associated with host activity and those produced by rotten oranges or oranges colonized by fungi were highly attractive for female wasps, whereas odours associated with the activity of the adults on the surface of the fruit, and those released by the fruit after being damaged (as happens during fruit fly egg-laying) were not used as cues by female parasitoids. Once the female had landed on the fruit, direct cues associated with larval activity became important although some indirect signals (e.g., products derived from larval activity inside the fruit) also increased host searching activity. Our findings indicate that naïve D. longicaudata uses chemical cues during host habitat searching and that these cues are produced both by the habitat and by the host larvae.","palabras_clave":"FORAGING BEHAVIOUR|SEMIOCHEMICALS|INFOCHEMICALS|TEPHRITIDAE|HOST HABITAT LOCATION|HYMENOPTERA|BRACONIDAE|DIPTERA|CERATITIS CAPITATA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88260,"idioma_id":4,"titulo":"Detoxification of Cr(VI) in Salvinia minima is related to seasonal-induced changes of thiols, phenolics and antioxidative enzymes","resumen":"In this study, protein- and non-protein-thiol-containing compounds (THCC), soluble phenolics (SP), proline (Pro), proteins and malondialdehyde (MDA) contents, and antioxidative enzyme activities were analyzed in floating and submerged leaves of Salvinia minima to establish their role against Cr-induced oxidative stress. We analyzed relationships among biochemical responses to different Cr(VI) concentrations to explore underlying mechanisms of Cr detoxification in plants growing under field conditions during summer and winter seasons. Significant increases in THCC were observed in submerged leaves from both seasons, while in floating leaves THCC increased only in summer being decreased in winter. Contrarily SP increased in floating leaves and decreased in submerged ones. MDA increased significantly in winter-leaves, but in summer-leaves remained unchanged. Antioxidative enzymes, i.e. guaiacol peroxidase (G-POD), superoxide dismutase (SOD) and catalase (CAT) showed different activity patterns. G-POD significantly increased in Cr-treated leaves from both seasons, while SOD increased in submerged leaves only, remaining practically unchanged in floating ones. CAT activity increased in floating leaves from both seasons, whereas in submerged ones was decreased or increased. Proteins increased in both leaf types during summer whereas decreased or remained unchanged in winter. Pro increased in wintersubmerged leaves only. Results show that seasonal-induced changes occur in all measured parameters.Salvinia minima to establish their role against Cr-induced oxidative stress. We analyzed relationships among biochemical responses to different Cr(VI) concentrations to explore underlying mechanisms of Cr detoxification in plants growing under field conditions during summer and winter seasons. Significant increases in THCC were observed in submerged leaves from both seasons, while in floating leaves THCC increased only in summer being decreased in winter. Contrarily SP increased in floating leaves and decreased in submerged ones. MDA increased significantly in winter-leaves, but in summer-leaves remained unchanged. Antioxidative enzymes, i.e. guaiacol peroxidase (G-POD), superoxide dismutase (SOD) and catalase (CAT) showed different activity patterns. G-POD significantly increased in Cr-treated leaves from both seasons, while SOD increased in submerged leaves only, remaining practically unchanged in floating ones. CAT activity increased in floating leaves from both seasons, whereas in submerged ones was decreased or increased. Proteins increased in both leaf types during summer whereas decreased or remained unchanged in winter. Pro increased in wintersubmerged leaves only. Results show that seasonal-induced changes occur in all measured parameters.","palabras_clave":"Salvinia minima|Chromium|Oxidative stress|Phenolics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88261,"idioma_id":5,"titulo":"Circuitos de granulación de urea: Análisis de diagramas de flujo alternativos","resumen":"En este trabajo se utiliza un simulador delcircuito de granulación de urea, previamentedesarrollado, para explorar diagramas de flujoalternativos al tradicional. La planta de granulaciónen estudio incluye un granulador de lecho fluidizado,una unidad de enfriamiento, zarandas vibratorias dedoble paño y molinos de rodillos. Con las nuevasconfiguraciones se busca disminuir la cantidad de finosque circulan en el sistema mediante la purga oderivación a disolución de fracciones o la totalidad dela corriente que abandona el molino de rodillos. Elanálisis de las distintas opciones permitió determinarque la incorporación de una zaranda a la salida dedicho equipo que separe las partículas menores a 1mm evitando o disminuyendo su ingreso al granulador,favorece la generación de producto dentro del rangode comercialización.","palabras_clave":"GRANULACION |CIRCUITOS|UREA|SIMULADOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88262,"idioma_id":4,"titulo":"Unique Processing During a Period of High Excitation\/Inhibition Balance in Adult-Born Neurons","resumen":"The adult dentate gyrus generates new granule cells (GCs) that develop over several weeks and integrate into the preexisting network. While adult hippocampal neurogenesis has been implicated in learning and memory, the specific role of new GCs remains unclear. We examined whether immature adult-born neurons contribute to information encoding. Combining calcium imaging and electrophysiology in acute slices we found that weak afferent activity recruits few mature GCs while activating a substantial proportion of the immature neurons. These different activation thresholds are dictated by an enhanced excitation\/inhibition balance transiently expressed in immature GCs. Immature GCs exhibit low input specificity that switches with time towards a highly specific responsiveness. Therefore, activity patterns entering the dentate gyrus can undergo differential decoding by a heterogeneous population of GCs originated at different times.","palabras_clave":"Neurogenesis|hippocampus|calcium imaging|electrophysiology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88263,"idioma_id":4,"titulo":"Requirement of adult-born neurons for hippocampus-dependent learning","resumen":"A fundamental question in the field of adult neurogenesis relies in addressing whether neurons generated in the adult dentate gyrus are needed for hippocampal function.  Increasing evidence is accumulating in support of the notion that hippocampus-dependent behaviors activate new neurons and that those neurons are highly relevant for information processing.  More specifically, immature new neurons under development that have unique functional characteristics begin to emerge as a highly relevant population in the dentate gyrus network. This review focuses on how hippocampus-dependent behaviors activate adult-born neurons and how modulation and ablation of adult hippocampal neurogenesis alter spatial and associative memory.  While several contradictory findings emerge when analyzing the literature, evidence in favor of a relevant role of young neurons in hippocampal function is compelling.                 ","palabras_clave":"ADULT NEUROGENESIS|BEHAVIOUR|LEARNING|SYNAPTIC PLASTICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88264,"idioma_id":4,"titulo":"The Composition of Mixed Micelles Formed by Dodecyl Trimethyl Ammonium Bromide and Benzethonium Chloride in Water","resumen":"&nbsp;&nbsp; The composition of the mixed micelles formed by hyamine (Hy) and dodecyltrimethylammonium bromide (DTAB) in water were experimentally determined by a combination of surfactant ion-selective electrodes and UV-vis spectroscopy measurements. Results were compared with the computed compositions from three theories on mixed micelles available in literature (Regular Solution, Motomura\u2019 and&nbsp; Georgiev\u2019s). Also the basis of Junquera and Aicart method and the determination of the micelle aggregation number (N) by pyrene fluorescence quenching,&nbsp; i.e., the constancy of N and the mixed micelle composition when the total concentration is changed, were not supported by our experimental results. Experimental micelle compositions were statistically equal to those computed by Regular Solution Theory. The mixed micelle composition and the amount of non-micellised surfactant molecules change&nbsp; with concentration above the critical micelle concentration, and then do not&nbsp; support the assumptions used in the Junquera and Aicart procedure and in the determination of the micelle aggregation number (N) by pyrene fluorescence quenching. The reason why the latter procedure gives N values similar to those obtained from other techniques is discussed.&nbsp;&nbsp; ","palabras_clave":"MIXED MICELLES COMPOSITION|RUBINGH|MOTOMURA MODEL|GEORGIEV MODEL|BENZETHONIUM|DODECYLTRIMETHYLAMMONIUM BROMIDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88265,"idioma_id":4,"titulo":"Bacterial  bio-resources for remediation of hexachlorocyclohexane","resumen":"In the last few decades, highly toxic organic compounds like the organochlorine pesticide (OP) hexachlorocyclohexane (HCH) have been released into the environment. All HCH isomers are acutely toxic to mammals. Although nowadays its use is restricted or completely banned in most countries, it continues posing serious environmental and health concerns. Since HCH toxicity is well known, it is imperative to develop methods to remove it from the environment. Bioremediation technologies, which use microorganisms and\/or plants to degrade toxic contaminants, have become the focus of interest. Microorganisms play a significant role in the transformation and degradation of xenobiotic compounds.Many Gram-negative bacteria have been reported to have metabolic abilities to attackHCH. For instance, several Sphingomonas strains have been reported to degrade thepesticide. On the other hand, among Gram-positive microorganisms, actinobacteria have a great potential for biodegradation of organic and inorganic toxic compounds. This review compiles and updates the information available on bacterial removal of HCH, particularly by Streptomyces strains, a prolific genus of actinobacteria. A brief account on the persistence and deleterious effects of these pollutant chemical is also given.","palabras_clave":"organochlorine pesticides|gamma-hexachlorocyclohexane|bioremediation|Streptomyces genus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88266,"idioma_id":5,"titulo":"La ciudad fragmentada y la producción del suelo residencial. Estudios de casos del aglomerado metropolitano Tucumán","resumen":"Se presentan avances de una línea de investigación orientada al estudio de las transformaciones territoriales, dinámicas, aspectos ambientales y escenarios prospectivos de planificación y gestión del Área Metropolita de Tucumán (AMeT), ciudad intermedia del sistema urbano de Argentina con cerca de 800.000 habitantes (INDEC 2010).    Las dinámicas de los últimos treinta años revelan la consolidación del proceso de metropolizacion. En el periodo se triplicó la cobertura de suelo urbano. Los datos analizados expresan un proceso explosivo de ?auge urbano?, en el que las urbanizaciones de baja densidad --promovidas tanto por los mecanismos de mercado formal e informal y asentamientos espontáneos, como por el estado provincial-- han generado un aglomerado que acusa notables desequilibrios ambientales, alto consumo de suelo de valor ecológico y productivo, e indicadores sociales que dan cuenta de un profundo proceso de diferenciación socio residencial y de desigual acceso a bienes y servicios urbanos.    Se analizan comparativamente casos a partir de la utilización de indicadores ambientales urbanos. Se utiliza la estructura metodológica de la matriz PEIR (presión, estado, impacto, respuesta) y SIG para el análisis espacial.     Las conclusiones aportan reflexiones sobre los interrogantes: i) ¿cuáles son los impactos territoriales y urbanos de estas intervenciones?; ii) ¿cómo repercute en términos sociales y ambientales la expansión urbana difusa?; iii) ¿cuál es el rol del estado y las políticas públicas?","palabras_clave":"transformaciones territoriales|segregación|indicadores|sustentabilidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88267,"idioma_id":4,"titulo":"Visual Control with Adaptive Dynamical Compensation for 3D Target Tracking by Mobile Manipulators","resumen":"In this paper an image-based dynamic visual feedback control for mobile manipulators is presented to solve the target tracking problem in the 3D-workspace. The design of the whole controller is based on two cascaded subsystems: a minimum norm visual kinematic controller which complies with the 3D target tracking objective, and an adaptive controller that compensates the dynamics of the mobile manipulator. Both the kinematic controller and the adaptive controller are designed to prevent from command saturation. Robot commands are defined in terms of reference velocities. Stability and robustness are proved by using Lyapunov\u2019s method. Finally, experimental results are presented to confirm the effectiveness of the proposed visual feedback controller.","palabras_clave":"Visual control|Mobile manipulator|Stability analysis|3D target tracking"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88268,"idioma_id":4,"titulo":"Passivity based visual servoing of mobile robots with dynamics compensation","resumen":"This paper presents an image-based dynamic visual servoing to make a mobile robot able to track a moving object on the workspace by using a calibrated on board vision system. The stability of the proposed system is proved based on its passivity properties. A robustness analysis and an L2-gain performance analysis are also presented. Experimental results are shown to illustrate the system performance.L2-gain performance analysis are also presented. Experimental results are shown to illustrate the system performance.","palabras_clave":"Visual servoing|Passivity|Mobile robots"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88269,"idioma_id":4,"titulo":"Adaptive Unified Motion Control of  Mobile Manipulators","resumen":"This paper presents a unified motion controller for mobile manipulators which not only solves the problems of point stabilization and trajectory tracking but also the path following problem. The control problem is solved based on the kinematic model of the robot. Then, a dynamic compensation is considered based on a dynamic model with inputs being the reference velocities to the mobile platform and the manipulator joints. An adaptive controller for on-line updating the robot dynamics is also proposed. Stability and robustness of the complete control system are proved through the Lyapunov method. The performance of the proposed controller is shown through real experiments. ","palabras_clave":"Mobile manipulator|Unified motion control|Nonlinear systems|Adaptive control"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88270,"idioma_id":4,"titulo":"Understanding the high neutralization yields in collisions of keV Li+ ions with copper surfaces","resumen":"Measurements of neutral atom fractions for Li+ scattered by Cu(111) and Cu(001) surfaces as a function of the exit ion energy and exit angle are reported. Large neutralization rates (between 20% and 60%) are found in all cases. A &#64257;rst-principles quantum-mechanical based theoretical formalism is applied to describethe time-dependent scattering process, where neutralization to the Li ground state is considered as the unique relevant charge transfer channel during the collision. The increase of the neutralization fraction as the exit energy decreases is well described by the model. The proximity of the projectile energy level to the solid Fermi level and the large extension of the ion-surface coupling interactions, affecting a large number of surface atoms, play a decisive role in explaining the experimental yields.","palabras_clave":"ION SCATTERING|COPPER SURFACES|NEUTRALIZATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88271,"idioma_id":4,"titulo":"Drainage and base level adjustments during evolution of a late Pleistocene piggy-back basin. Eastern Cordillera, Central Andes of NW Argentina","resumen":"In northwestern Argentina, mid-Pleistocene out-of-sequence thrusting further disrupted the Andean foreland, giving rise to the Lerma piggyback basin within the Eastern Cordillera. Emergent topography along the eastern edge of the basin, as well as in its interior, interfered with preexisting eastward-flowing river courses. In the northern part of the Lerma basin, rivers temporarily incised across the new topography, yielding wind and water gaps, and in places preserving straths with treads tilted upstream, revealing their tectonic origin. Application of Hack?s law shows correspondence between the active and the abandoned channel profiles. Bed profiles of wind gaps are distinct from those of nearby consequent streams. Defeated and deflected northern streams coalesced into a trunk stream, which maintained an open channel across the eastern bounding ranges. River defeat may have been related to rain shadowing by the growing topographic barrier and retention of easterly derived moisture outside the Lerma basin. In the southern Lerma basin, river courses were not generally capable of sustaining active water gaps. Instead, they were deflected southward, and their discharges fed ancient Lake Lerma. Lake expansion ensued until water level reached a structural low, through which lake waters outflowed from the basin and subsequently incised across the eastern bounding ranges. The relative success of northern rivers in incising across the rising topographic barrier is mainly attributed to their greater channel gradients at the point of incision, combined with high rainfall. Longitudinal channel profiles show that rivers in the northern Lerma basin had   34 approached their base level of erosion before uplift of the eastern bounding ranges. After this disturbance, the system continues to approach a new base level of erosion, modified by sediment aggradation within the basin. Speculatively, mid-Pleistocene out-of-sequence thrusting is  37 attributed to basement uplift in the distal foreland.aggradation within the basin. Speculatively, mid-Pleistocene out-of-sequence thrusting is attributed to basement uplift in the distal foreland.","palabras_clave":"ARGENTINA|GEOMORFOLOGIA|ANDES|FLUVIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88272,"idioma_id":5,"titulo":"Orogénesis y drenaje en la región del valle de Lerma (Cordillera Oriental, Salta, Argentina) durante el Pleistoceno tardío","resumen":"En el Pleistoceno tardío, luego de la incipiente elevación de las serranías subandinas, la contracción retornó al interior del orógeno.  En aquel tiempo un piedemonte conectaba los contrafuertes occidentales de la Cordillera Oriental (sierras de Lesser y  Obispo) con la llanura subandina, a través de la región que hoy ocupan el valle de Lerma y la serranía Mojotoro-Castillejo. La  contracción dio origen a las elevaciones interiores en la sierra de Vaqueros y los Cerrillos de San Miguel, y luego se propagó al  este con un falla inversa que derivó en el desarrollo de la serranía Mojotoro-Castillejo y el cierre del valle de Lerma. Algunos  ríos incidieron a través de las nacientes barreras topográficas mientras que otros fueron a una cuenca endorreica inundada por  un antiguo lago Lerma. La capacidad de incisión fue mayor en el valle de Lerma septentrional, donde los ríos llegaban con  gradientes de cauce elevados a los sitios de ascenso topográfico, y donde el río Mojotoro persistió como cauce antecedente.  En el sur, el lago Lerma colmató la cuenca hasta un punto de derrame por bajos estructurales en capas del Grupo Salta, y el  agua labró el cauce subsecuente del actual río Juramento a través de la sierra de Castillejo. Más de 800 m de sedimento (aquí  denominado Grupo Valle de Lerma) se acumularon en el valle de Lerma durante el Pleistoceno tardío. Información de subsuelo  permite hacer una revisión crítica de la estratigrafía de este relleno y proponer una subdivisión más detallada. En particular  se acota la extensión geográfica de la Formación Tajamar y se revisan las extrapolaciones que de ella se han hecho.","palabras_clave":"ARGENTINA|ANDES|GEOMORFOLOGIA|FLUVIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88273,"idioma_id":5,"titulo":"Efecto amplificador del suelo en la exposición al peligro sísmico de Tolhuin, Tierra del Fuego, Argentina","resumen":"La Isla Grande de Tierra del Fuego (Argentina-Chile) está situada en un entorno de intensa actividad sísmica merced a la interacción de las placas tectónicas Antártica, Scotia y Sudamericana. Dos zonas sismotectónicas en esta región: la fosa de subducción en el extremo austral de Chile Magallanes-Fagnano, que cruza la isla de este a oeste, representan una amenaza sísmica para la población local. únicamente el sector argentino de la Tierra del Fuego, sin embargo,la mayor amenaza proviene de la Fagnano, la cual ha generado eventos sísmicos de magnitud M=8 en tiempos históricos. Tolhuin, una 3000 habitantes en rápido crecimiento, está a 1 km de la traza de esta falla. Las construcciones parte no han tenido el control de sismorresistencia que requiere el INPRES (Instituto Nacional de Prevención otra parte, la urbanización de Tolhuin apoya sobre un espeso paquete de sedimentos glacigénicos del Cuaternario cuyas características geotécnicas sugieren que puede amplificar a más del doble una vibración sísmica, de acuerdo a una simulación con EERA (Equivalent-linear Earthquake Analyses). Aplicando la metodología Risk Assessment Tools for Diagnosis of Urban Areas against Seismic Disasters (RADIUS) propiciada por las Naciones Unidas, este estudio analiza la vulnerabilidad edilicia de Tolhuin ante un Terremoto Máximo Considerado de M=8,0. Los resultados muestran la importancia de tomar en cuenta la probable amplificación local por el efecto suelo. El presente trabajo constituye un primer esfuerzo concertado para dotar a la provincia argentina de Tierra del Fuego de herramientas cartográficas y conceptuales útiles para planificar el crecimiento urbano tomando en cuenta la prevención sísmica.","palabras_clave":"ARGENTINA|RIESGO SISMICO|TERREMOTOS|FALLA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88274,"idioma_id":4,"titulo":"Holocene paleoseismicity in southern Patagonia (Argentina-Chile; 52º-55ºS); the role of the Magallanes-Fagnano transform fault","resumen":"Patagonia, including the island of Tierra del Fuego, lies in southernmost South America at the junction of the South American, Antarctic, and Scotia tectonic plates. Historical and instrumental records have documented several local earthquakes of damaging magnitude, posing a threat to the rapidly growing population of 300,000 and the expanding industrial and service infrastructure. Short and inaccurate instrumental records of local seismic events and a diffuse epicenter distribution not clearly related to the recognized seismogenic structures have hindered an adequate evaluation of the seismic hazard for this region. To improve this situation, a paleoseismological study was carried out on two gravelly strandplains on the Atlantic coast of Patagonia. Surveying combined ground-probing radar, vertical electric sounding, and seismic refraction. Coseismic normal faults buried beneath the strandplain bodies were revealed and related to the morphology of the strandplains. The faults have probable ages between 0.9 and 6.4 kyr BP and a recurrence rate of about 1 kyr. The more likely source for these structures is the Magallanes-Fagnano fault, a continental transform fault that crosses Tierra del Fuego. The distance of more than 300 km from the buried coseismic structures to the trace of the Magallanes-Fagnano fault argues for high-magnitude earthquake activity on this fault throughout the Holocene. Urban development on soft glacial and alluvial substrates increases the hazard.","palabras_clave":"riesgo sismico|Argentina|Tierra del Fuego|falla"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88275,"idioma_id":4,"titulo":"Observational constraints for the circumstellar disk of the  B[e] star CPD-52 9243","resumen":"     Molecular emission has been detected in several Magellanic Cloud B[e] supergiants. In this Letter, we report on the detection of CO band head emission in the B[e] supergiant LHA 115-S 65, and present a K-band near-infrared spectrum obtained with the Spectrograph forINtegral Field Observation in the Near-Infrared (SINFONI; R=4500) on the ESO VLT UT4 telescope. The observed molecular band head emission in S 65 is quite surprising in light of a previous  non-detection by McGregor et al. (1989), as well as a high resolution (R=50000) Gemini\/Phoenix spectrum of this star taken nine months earlier showing no emission. Based on analysis of the optical spectrum by Kraus et al. (2010), we suspect that the sudden appear-ance of molecular emission could be due to density build up in an outflowing viscous disk, as seen for Be stars. This new discovery, combined with variability in two other similar evolved massive stars, indicates an evolutionary link between B[e] supergiants and LBVs.","palabras_clave":"STARS: SUPERGIANTS|STARS: WINDS, OUTFLOWS|STARS: MASS-LOSS|CIRCUMSTELLAR MATTER|STARS: INDIVIDUAL (CPD-52 9243)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88276,"idioma_id":4,"titulo":"The sudden appearance of CO emission in LHA 115-S 65","resumen":"Molecular emission has been detected in several Magellanic Cloud B[e]  supergiants. In this Letter, we report on the detection of CO band head  emission in the B[e] supergiant LHA 115-S 65, and present a K-band  near-infrared spectrum obtained with the Spectrograph for INtegral Field  Observation in the Near-Infrared (SINFONI; R=4500) on the ESO VLT UT4  telescope. The observed molecular band head emission in S 65 is quite  surprising in light of a previous non-detection by McGregor et al. 1989, as  well as a high resolution (R=50000) Gemini\/Phoenix spectrum of this star taken  nine months earlier showing no emission. Based on analysis of the optical  spectrum by Kraus et al. 2010, we suspect that the sudden appearance of  molecular emission could be due to density build up in an outflowing viscous  disk, as seen for Be stars. This new discovery, combined with variability in  two other similar evolved massive stars, indicates an evolutionary link between  B[e] supergiants and LBVs.","palabras_clave":"CIRCUMSTELLAR MATTER|STARS: EMISSION-LINE, BE|STARS: INDIVIDUAL: LHA 115-S 65|SUPERGIANTS|STARS: WINDS, OUTFLOWS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88277,"idioma_id":4,"titulo":"The spectroscopic orbits and physical parameters of GG Carinae","resumen":"Aims. GG Car is an eclipsing binary classified as a B[e] supergiant star. The aims of our study are to improve the orbital elements of  the binary system in order to obtain the actual orbital period of this system. We also compare the spectral energy distribution of the  observed fluxes over a wide wavelength range with a model of a circumstellar envelope composed of gas and dust. This fitting allows  us to derive the physical parameters of the system and its environment, as well as to obtain an estimation of the distance to GG Car.   Methods. We analyzed about 55 optical and near infrared spectrograms taken during 1996-2010. The spectroscopic orbits were  obtained by measuring the radial velocities of the blueshifted absorptions of the He I P-Cygni profiles, which are very representative  of the orbital motion of both stars. On the other hand, we modeled the spectral energy distribution of GG Car, proposing a simple  model of a spherical envelope consisting of a layer close to the central star composed of ionized gas and other outermost layers  composed of dust. Its effect on the spectral energy distribution considering a central B-type star is presented. Comparing the model with the observed continuum energy distribution of GG Car, we can derive fundamental parameters of the system, as well as global  physical properties of the gas and dust envelope. It is also possible to estimate the distance taking the spectral regions into account  where the theoretical data fit the observational data very well and using the set of parameters obtained and the value of the observed  flux for different wavelengths.  Results. For the first time, we have determined the orbits for both components of the binary through a detailed study of the He I lines,  at &#955;&#955;4471, 5875, 6678, and 7065 Å, thereby obtaining an orbital period of 31.033 days. An eccentric orbit with e = 0.28 and a mass  ratio q = 2.2 ± 0.9 were calculated. Comparing the model with the observed continuum energy distribution of GG Car, we obtain  T e f f = 23000K and log g = 3. The central star is surrounded by a spherical envelope consisting of a layer of 3.5 stellar radii composed  of ionized gas and other outermost dust layers with E B&#8722;V = 0.39. These calculations are not strongly modified if we consider two  similar B-type stars instead of a central star, provided our model suggests that the second star might contribute less than 10% of the  primary flux. The calculated effective temperature is consistent with an spectral type B0-B2 and a distance to the object of 5 ± 1 kpc  was determined.","palabras_clave":"TECHNIQUES: SPECTROSCOPIC|BINARIES: ECLIPSING|STARS: INDIVIDUAL: GG CAR|STARS: EMISSION-LINE, BE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88278,"idioma_id":5,"titulo":"La fauna de porte menor en sitios arqueológicos de la región pampeana, Argentina. Agente disturbador vs. recurso económico","resumen":"En este trabajo se discute la presencia de animales de porte mediano y pequeño, particularmente roedores, armadillos, aves y peces, en los conjuntos arqueofaunísticos de sitios ubicados en distintas áreas de la región pampeana (Argentina) y con cronologías que van desde el Holoceno temprano al Holoceno tardío. Se analiza su potencial como recurso económico explotado por los cazadores recolectores, así como su incidencia en los procesos de formación de sitios.  El objetivo es plantear el rol de los taxa pequeños en el entorno ambiental y cultural, realizando un análisis comparativo a nivel espacial y temporal; asimismo, se analiza la acción antrópica sobre estos taxones y se generan interpretaciones sobre las estrategias económicas que involucraron su incorporación a la dieta y el aprovechamiento de otros subproductos. Los conjuntos estudiados provienen de la localidad arqueológica Cañada Honda y el sitio Río Luján (Noreste de la provincia de Buenos Aires); los sitios La Guillerma 1, La Guillerma 5 y  San Ramón 7 (Depresión del Salado); Laguna Tres Reyes 1, Arroyo Seco 2 y El Guanaco (área Interserrana bonaerense) y Paso Mayor y Barrio Las Dunas (Sudoeste bonaerense).","palabras_clave":"FAUNA MENOR|CONTEXTO ARQUEOLÓGICO|RECURSOS ECONÓMICOS|AGENTES TAFONÓMICOS,"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88279,"idioma_id":4,"titulo":"Phase recovery improvement using analytic wavelet transform analysis of a noisy interferogram cepstrum","resumen":"We evaluate the extension of the exact nonlinear reconstruction technique developed for digital holography to the phase-recovery problems presented by other optical interferometric methods, which use carrier modulation. It is shown that the introduction of an analytic wavelet analysis in the ridge of the cepstrum transformation corresponding to the analyzed interferogram can be closely related to the well-known wavelet analysis of the interferometric intensity. Subsequently, the phase-recovery process is improved. The advantages and limitations of this framework are analyzed and discussed using numerical simulations in singular scalar light fields and in temporal speckle pattern interferometry.","palabras_clave":"Digital holography|Digital image processing|Phase retrieval |Speckle imaging"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88280,"idioma_id":4,"titulo":"Arabidopsis heterotrimeric G protein regulates cell wall  defense and  resistance to necrotrophic fungi","resumen":"The Arabidopsis heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi. The agb1 mutant impaired in the Gb subunit displays enhanced susceptibility to these pathogens. Gb\/AGB1 forms an obligate dimer with either one of the Arabidopsis Gg subunits (g1\/AGG1 and g2\/AGG2). Accordingly, we now demonstrate that the agg1 agg2 double mutant is as susceptible as agb1 plants to the necrotrophic fungus Plectosphaerella cucumerina. To elucidate the molecular basis of heterotrimeric G-protein-mediated resistance, we performed a comparative transcriptomic analysis of agb1-1 mutant and wild-type plants upon inoculation with P. cucumerina. This analysis, together with metabolomic studies, demonstrated that G-protein-mediated resistance was independent of defensive pathways required for resistance to necrotrophic fungi, such as the salicylic acid, jasmonic acid, ethylene, abscisic acid, and tryptophan-derived metabolites signaling, as these pathways were not impaired in agb1 and agg1 agg2 mutants. Notably, many mis-regulatedgenes in agb1 plants were related with cell wall functions, which was also the case in agg1 agg2 mutant. Biochemical analyses and Fourier Transform InfraRed (FTIR) spectroscopy of cell walls from G-protein mutants revealed that the xylose content was lower in agb1 and agg1 agg2 mutants than in wild-type plants, and that mutant walls had similar FTIR spectratypes, which differed from that of wild-type plants. The data presented here suggest a canonical functionality of the Gband Gg1\/g2 subunits in the control of Arabidopsis immune responses and the regulation of cell wall composition. ","palabras_clave":"G-protein|Cell wall|Pathogen resistance|arabidopsis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88281,"idioma_id":4,"titulo":"Early detection of toxigenic Fusarium graminearum in wheat","resumen":"Fusarium graminearum (Schwabe) contaminates agricultural crops   and commodities with trichothecenes, mostly deoxynivalenol and its   acetyl-derivatives. Current techniques available to detect final   mycotoxin contamination products usually require an extended time lag   between sampling and the corresponding report, and include different   clean-up steps and eventually derivatisation. This study was aimed to   develop a methodology to detect toxigenic F. graminearum prior to   mycotoxin production. Headspace solid-phase microextraction coupled to   capillary gas chromatography is shown to be useful to predict the   potential of trichothecene mycotoxin formation by detecting the presence   of F. graminearum at early stages of fungal growth in wheat   cultivars, based on the detection of trichodiene (TRI), the volatile   intermediate of trichothecenes. We showed that TRI is a useful marker to   detect toxigenic Fusarium in wheat spikes from live plants, regardless of the actual development of Fusarium   head blight (FHB). This is the first predictive methodology for FHB and   trichothecene occurrence in field-collected samples. It might be a   useful tool to help to prevent the risk of mycotoxin contamination.","palabras_clave":"FUSARIUM HEAD BLIGHT|TRICHODIENE|VOLATILE ORGANIC COMPOUNDS|SOLID PHASE MICROEXTRACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88282,"idioma_id":5,"titulo":"Sobre la presencia de un supuesto Haplodontheriinae (Mammalia, Toxodontidae)  en el Pleistoceno tardío de la provincia de Corrientes, Argentina.","resumen":"Sobre la presencia de un supuesto Haplodontheriinae (Mammalia, Toxodontidae) en el Pleistoceno tardío de la provincia de Corrientes (Argentina) Miño Boilini, A.R., Zurita, A.E., Bond, M., FRancia, A. y E. SoibelzonResumen: En el extremo sur de Sudamérica se han postulado varias áreas que   podrían haber actuado como reservorio de taxones supérstites,   especialmente en el lapso Mioceno-Pleistoceno tardío   ('Araucanense'-Lujanense). Así, en el Pleistoceno tardío (ca.   58-28 ka) de la provincia de Corrientes, Argentina, se ha reconocido la   persistencia de ciertos taxones ya desaparecidos en la región pampeana   de Argentina, particularmente entre los Xenarthra Glyptodontidae,   Artiodactyla Cervidae y Notoungulata 'Haplodontheriinae'. Aquí se   efectua una revisión con criterios taxonómicos modernos de los   materiales (3 restos dentarios) asignados a Toxodontidae   Haplodontheriinae, cuyos registros últimos en la región pampeana   provienen del Montehermosense (Plioceno). El estudio comparado indica   que los 2 'caniniformes' superiores derechos (CTES-PZ 1608, 1609)   corresponden en realidad a un Xenarthra Phyllophaga (Lestodon), en tanto que el tercero (CTES-PZ 1610) debe ser asignado a un Notoungulata (Toxodon),   ambos géneros típicos del Pleistoceno de América del Sur. Por último,   las revisiones sistemáticas que se llevan a cabo son claves para refinar   el registro paleontológico regional, y brindar un aporte fundamental al   esquema bioestratigráfico en áreas extra-pampeanas.","palabras_clave":"Taxonomía|Supérstites|América|Cuaternario"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88283,"idioma_id":5,"titulo":"Primer registro de Synbranchiformes (Teleostei) para el Holoceno temprano de Argentina","resumen":"En este trabajo se presentan y describen los restos óseos de peces Synbranchidae cf. Synbranchus recuperados en los niveles fosilíferos de la Formación Río Bermejo de la localidad de Mansilla, sudeste de la provincia de Formosa, Argentina. Estos materiales constituyen los únicos restos de peces recuperados en dicha localidad y fueron hallados asociados a mamíferos fósiles característicos de finales del Pleistoceno y comienzos del Holoceno. Hasta el presente solo se conocen escasos restos fósiles de sinbránquidos en América del Sur. Los restos más antiguos corresponden a la parte más baja del Pleistoceno Superior (\u201CBelgranense\u201D) de la región Pampeana de Buenos Aires. Los materiales de la Formación Río Bermejo representan el primer registro fósil conocido de unSynbranchidae cf. Synbranchus para el Holoceno temprano.","palabras_clave":"Synbranchidae|Synbranchus|Formacion Río Bermejo|Pleistoceno-Holoceno"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88284,"idioma_id":4,"titulo":"Robust MPC for tracking zone regions based on nominal predictions","resumen":"This paper deals with the problem of robust tracking of target sets   using a model predictive control (MPC) law. Real industries applications   often require a control strategy in which some system outputs are   controlled within specified ranges or zones (zone control), while some   others variables ? possibly including input variables ? are steered to   fixed target or setpoint. From a theoretical point of view, the control   objective of this kind of problem can be seen as a target set (in the   output space) instead of a target point, since inside the zones there   are no preferences between one point or another. This problem is   particularly interesting in case of additive disturbances which might   push the outputs out of the zones. In this work, a stable robust MPC   formulation for constrained linear systems, based on nominal predictions   is presented. The main features of this controller are the use of   nominal predictions, restricted constraints and the concept of distance   from a point to a set as offset cost function. The controller ensures   both recursive feasibility and local optimality. The properties of the   controller are shown in a simulation test, in which we consider a   subsystem of an industrial FCC system.","palabras_clave":"MODEL PREDICTIVE CONTROL|RESTRICTED CONSTRAINTS|ZONE CONTROL|TARGET SET TRACKING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88285,"idioma_id":4,"titulo":": Flexibility along the neck of the neogene terror bird Andalgalornis steulleti (Aves Phorusrhacidae)","resumen":"Background: Andalgalornis steulleti from the upper Miocene?lower Pliocene (&lt;6 million years ago) of Argentina is  a medium-sized patagornithine phorusrhacid. It was a member of the predominantly South American radiation of ?terror  birds? (Phorusrhacidae) that were apex predators throughout much of the Cenozoic. A previous biomechanical study  suggests that the skull would be prepared to make sudden movements in the sagittal plane to subdue prey.  Methodology\/Principal Findings: We analyze the flexion patterns of the neck of Andalgalornis based on the neck vertebrae  morphology and biometrics. The transitional cervical vertebrae 5th and 9th clearly separate regions 1?2 and 2?3  respectively. Bifurcate neural spines are developed in the cervical vertebrae 7th to 12th suggesting the presence of a very  intricate ligamentary system and of a very well developed epaxial musculature. The presence of the lig. elasticum  interespinale is inferred. High neural spines of R3 suggest that this region concentrates the major stresses during  downstrokes.  Conclusions\/Significance: The musculoskeletal system of Andalgalornis seems to be prepared (1) to support a particularly  big head during normal stance, and (2) to help the neck (and the head) rising after the maximum ventroflexion during  a strike. The study herein is the first interpretation of the potential performance of the neck of Andalgalornis in its entirety  and we considered this an important starting point to understand and reconstruct the flexion pattern of other  phorusrhacids from which the neck is unknown.","palabras_clave":"AVES|PHORUSRHACIDAE|NECK FLEXIBILITY|PALEOBIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88286,"idioma_id":5,"titulo":"Carácter científico y profesional de la psicopedagogía. Representaciones de estudiantes de la carrera de Psicopedagogía en Rosario, Argentina","resumen":"      La institucionalización académica de la psicopedagogía ha generado debates en relación a sus tradiciones conceptuales y abordajes profesionales, expresión de ello resultan ciertas dificultades para delimitar el campo de la misma en vinculación con la ?educación?, la ?psicología? y la ?psicopedagogía?. El objetivo principal de este trabajo fue explorar las representaciones de estudiantes universitarios de la carrera acerca del carácter científico y profesional de la psicopedagogía. Se aplicó un cuestionario construido ad hoc a 134 estudiantes (80,2% de la población) de los últimos tres años de la carrera en la Universidad Nacional de San Martín (Sede Rosario). El instrumento exploró dos dimensiones de análisis: campo científico y formación académico-profesional. El análisis realizado fue estadístico-descriptivo. En coherencia con la literatura académica revisada, los resultados muestran una tendencia a definir a la psicopedagogía como un quehacer profesional con un carácter fundamentalmente práctico que se destaca por una escasa producción científica. De acuerdo a lo expresado por los participantes, este campo de conocimiento se ocuparía de estudiar al sujeto en situación de aprendizaje. En la formación académica, sostuvieron que la disciplina predominante es la psicología, siendo sus vertientes principales, el psicoanálisis y la psicología genética. Acerca de la formación profesional, consideraron que el perfil del psicopedagogo se orienta hacia la detección de problemas de aprendizaje. Los resultados presentados demuestran la necesidad de impulsar espacios de discusión y participación colectiva en ámbitos académicos a los fines de que la psicopedagogía pueda consolidar su identidad y generar sus propias tradiciones conceptuales.  ","palabras_clave":"REPRESENTACIONES|PSICOPEDAGOGÍA|FORMACIÓN PROFESIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88287,"idioma_id":4,"titulo":"IL-17 and IFN-g expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease","resumen":"Th1 lymphocytes are crucial in the immune responseagainst Mycobacterium tuberculosis. Nevertheless,IFN- alone is not sufficient in the complete eradicationof the bacteria, suggesting that other cytokines mightbe required for pathogen removal. Th17 cells have beenassociated with M. tuberculosis infection, but the roleof IL-17-producing cells in human TB remains to be understood.Therefore, we investigated the induction andregulation of IFN- and IL-17 during the active disease.TB patients were classified as High and Low Responderindividuals according to their T cell responsesagainst the antigen, and cytokine expression upon M.tuberculosis stimulation was investigated in peripheralblood and pleural fluid. Afterwards, the potential correlationamong the proportions of cytokine-producingcells and clinical parameters was analyzed. In TB patients,M. tuberculosis induced IFN- and IL-17, but incomparison with BCG-vaccinated healthy donors, IFN-results were reduced significantly, and IL-17 was markedlyaugmented. Moreover, the main source of IL-17was represented by CD4IFN-IL-17 lymphocytes, aTh1\/Th17 subset regulated by IFN-. Interestingly, theratio of antigen-expanded CD4IFN-IL-17 lymphocytes,in peripheral blood and pleural fluid from TB patients,was correlated directly with clinical parametersassociated with disease severity. Indeed, the highestproportion of CD4IFN-IL-17 cells was detected inLow Responder TB patients, individuals displaying severepulmonary lesions, and longest length of diseaseevolution. Taken together, the present findings suggestthat analysis of the expansion of CD4IFN-IL-17 Tlymphocytes in peripheral blood of TB patients might beused as an indicator of the clinical outcome in activeTB.","palabras_clave":"tuberculosis|Th1\/Th17 cells|cytokines|costimulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88288,"idioma_id":4,"titulo":"Inflammatory Mediators in Exhaled Breath Condensate of Healthy Donors and Exacerbated COPD Patients","resumen":"Samples of exhaled breath condensate (EBC) provide a convenient and non-invasive method to study inflammation in lung diseases. The aim of the present study was to evaluate and compare the inflammatory protein mediator levels in EBC from healthy donors (HD) and from patients with exacerbation of chronic obstructive pulmonary disease (COPD) using an EBC collection device with and without a coating of albumin as a carrier. We studied 13 HD and 26 patients with exacerbation of COPD. The concentrations of myeloperoxidase (MPO), IFNã and secretory leukocyte protease inhibitor (SLPI) in EBC were measured by immunoassays. The EBC samples from HD and COPD patients showed higher concentrations of MPO when samples were recovered with an albumin-coated device. Furthermore, levels of MPO in COPD patients were significantly higher than in HD. An inverse correlation was observed between MPO and spirometric parameters (FVC and FEV1). Almost all samples collected with the albumin-coated device showed higher amounts of IFNã and SLPI than those collected with the uncoated device. The levels of SLPI in COPD patients were significantly higher than in HD. A direct correlation was observed between FVC% predicted and SLPI. We concluded that coating the collection device with albumin increased the sensitivity of the technique, at least for measurements of MPO, SLPI and IFNã. Furthermore, the higher levels of MPO and SLPI and lower levels of IFNã in EBC from COPD patients could reflect the immunological status and the response of lung parenchyma to treatment during the exacerbation of the illness.","palabras_clave":"COPD |INFLAMACION |CONDENSADO DE AIRE ESPIRADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88289,"idioma_id":4,"titulo":"Technological and probiotic role of adjunct cultures of non starter lactobacilli in soft cheeses","resumen":"The influence of two cheese-isolated Lactobacillus strains on cheese composition, acceptability and probiotic capacity was assessed. Soft cheeses with and without the addition of Lactobacillus plantarum I91 or Lactobacillus paracasei I90 were prepared. Gross composition was assessed and secondary proteolysis was described by soluble fractions and free amino acids profiles. Acceptability was determined by a panel of 98 non-trained consumers. Cheeses harboring added Lactobacillus strains were also studied in vivo to evaluate their probiotic capacity. Gross composition of the cheeses was similar for control and treated (Lactobacillus-added) cheeses. Peptidolysis increased in cheeses with added lactobacilli, which was evidenced by a higher free amino acid content. Overall, the acceptability of the cheeses was good: 65% e 80% of the consumers said that they liked very much or liked the cheeses. Cheeses with L. plantarum I91 showed the highest changes in composition and proteolysis and were the most accepted ones. On the contrary, composition of cheeses with L. paracasei I90 was similar to that of the controls, but these samples were less accepted than cheeses without lactobacilli. The oral administration of cheese containing L. plantarum I91 or L. paracasei I90 proved to be safe and able to enhance the number of IgA þ cells in the small intestine lamina propria of mice. The use of selected strains of NSLAB exerted a technological and probiotic role: it contributed to the standardization of cheese quality and induced benefic health effects at the gut mucosa in vivo.","palabras_clave":"Probiotics|NSLAB|Lactobacillus Plantarum|Lactobacillus Paracasei|Soft Cheese"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88290,"idioma_id":4,"titulo":"Preservation of functionality of Bifidobacterium animalis subsp. lactis INL1 after incorporation of freeze-dried cells into different food matrices","resumen":"The aim of this work was to investigate how production and freeze-drying conditions of Bifidobacterium animalis subsp. lactis INL1, a probiotic strain isolated from breast milk, affected its survival and resistance to simulated gastric digestion during storage in food matrices. The determination of the resistance of bifidobacteria to simulated gastric digestion was useful for unveiling differences in cell sensitivity to varying conditions during biomass production, freeze-drying and incorporation of the strain into food products. These findings show that bifidobacteria can become sensitive to technological variables (biomass production, freeze-drying and the food matrix) without this fact being evidenced by plate counts.","palabras_clave":"."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88291,"idioma_id":4,"titulo":"Cell viability and immunostimulating and protective capacities of B. longum 51A are differentially affected by technological variables in fermented milks","resumen":"    Aim: To investigate the cell viability of B. longum 51A in fermented milks and to study its immunostimulating  and protective capacity against Salmonella  infection in mice.    Methods and Results: B. longum 51A was added to milk fermented with different yoghurt starters,  before or after fermentation, and viability was monitored during storage (5ºC, 28 days). Resistance to  simulated gastric acid digestion was assessed. Fermented milks were orally  administered to mice for 10 days followed by oral infection with Salmonella Typhimurium. The number of  IgA+ cells in the small and large intestine was determined before infection.  Survival to infection was monitored for 20 days. B. longum 51A lost viability during storage, but the  product containing it was effective for the induction of IgA+ cells  proliferation in the gut and for the protection of mice against S. Typhimurium infection.     Conclusions:  cell viability of B. longum 51A in  fermented milks along storage did not condition the capacity of the strain to enhance  the number of IgA+ cells in the gut and to protect mice against Salmonella infection.    Significance and Impact of the Study: The uncoupling of cell  viability and functionality demonstrated that, in certain cases, non viable  cells can also exert positive effects.   ","palabras_clave":"BIFIDOBACTERIA|VIABILITY|FERMENTED MILKS|IMMUNOMODULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88292,"idioma_id":4,"titulo":"Effect of a non-lethal High Pressure Homogenization treatment on the in vivo response of probiotic lactobacilli","resumen":"Low levels of High Pressure of Homogenization (HPH) can be applied directly to lactic acid bacteria cells in order to enhance some functional properties. In a previous work we observed that a 50 MPa HPH treatment increased Lactobacillus paracasei A13 hydrophobicity and resistance to simulated gastric digestion. The aim of this work was to assess the in vivo effects of HPH treatment applied to probiotic lactobacilli on their interaction capacity with the gut and on their ability to induce IgA cell proliferation in mice intestine. BALB\/c mice received FITC-labelled cultures of strains, previously treated or not (control) at 50 MPa. Fluorescently labelled cells were studied in the intestine of animals sacrificed 10 and 30 min after intragastric intubation. HPH-treated and control cultures of each strain were orally administered to mice for 2, 5 or 7 consecutive days. The number of IgA-producing cells in the gut was studied by immunohistochemistry. HPH treated probiotic lactobacilli modified their interaction with the small intestine. HPH-treated cells induced a higher IgA response compared to untreated ones, in a strainand feeding period-dependent way. HPH treatment could increase some in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.Lactobacillus paracasei A13 hydrophobicity and resistance to simulated gastric digestion. The aim of this work was to assess the in vivo effects of HPH treatment applied to probiotic lactobacilli on their interaction capacity with the gut and on their ability to induce IgA cell proliferation in mice intestine. BALB\/c mice received FITC-labelled cultures of strains, previously treated or not (control) at 50 MPa. Fluorescently labelled cells were studied in the intestine of animals sacrificed 10 and 30 min after intragastric intubation. HPH-treated and control cultures of each strain were orally administered to mice for 2, 5 or 7 consecutive days. The number of IgA-producing cells in the gut was studied by immunohistochemistry. HPH treated probiotic lactobacilli modified their interaction with the small intestine. HPH-treated cells induced a higher IgA response compared to untreated ones, in a strainand feeding period-dependent way. HPH treatment could increase some in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.in vivo effects of HPH treatment applied to probiotic lactobacilli on their interaction capacity with the gut and on their ability to induce IgA cell proliferation in mice intestine. BALB\/c mice received FITC-labelled cultures of strains, previously treated or not (control) at 50 MPa. Fluorescently labelled cells were studied in the intestine of animals sacrificed 10 and 30 min after intragastric intubation. HPH-treated and control cultures of each strain were orally administered to mice for 2, 5 or 7 consecutive days. The number of IgA-producing cells in the gut was studied by immunohistochemistry. HPH treated probiotic lactobacilli modified their interaction with the small intestine. HPH-treated cells induced a higher IgA response compared to untreated ones, in a strainand feeding period-dependent way. HPH treatment could increase some in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.ficed 10 and 30 min after intragastric intubation. HPH-treated and control cultures of each strain were orally administered to mice for 2, 5 or 7 consecutive days. The number of IgA-producing cells in the gut was studied by immunohistochemistry. HPH treated probiotic lactobacilli modified their interaction with the small intestine. HPH-treated cells induced a higher IgA response compared to untreated ones, in a strainand feeding period-dependent way. HPH treatment could increase some in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.fied their interaction with the small intestine. HPH-treated cells induced a higher IgA response compared to untreated ones, in a strainand feeding period-dependent way. HPH treatment could increase some in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.in vivo functional characteristics of probiotic strains, highlighting the potential of this technique for the development of probiotic cultures.","palabras_clave":"."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88293,"idioma_id":4,"titulo":"Theoretical and experimental study on the reaction route for the FVP of 2-thioxohexahydroquinazolinones","resumen":"Structural and conformational analyses through the use of different spectrometric techniques as well as DFT calculations performed to analyze the results of FVP reactions on pure cis as well as pure trans 2-thioxo- hexahydroquinazolinones yielding isothiocyanates as main products have been carried out. With these, we could assess the specific tautomer\/isomer\/conformer that produces the products in each FVP reaction. It was confirmed that for both isomers, the reaction takes place from the thiol tautomer, and for the special case of the cis isomer, the conformer involved is the N(1)-in.","palabras_clave":"Flash Vacuum Pyrolysis|2-thioxohexahydroquinazolinones|Reactivity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88294,"idioma_id":4,"titulo":"Nitric oxide and flavonoids are systemically induced by UV-B in maize leaves","resumen":"Flavonoids are UV-B absorbing compounds whose concentration, increase in plant cells stimulated by UVB irradiation. In this work, we characterized the systemic accumulation of flavonoids in maize seedlings irradiated with 3.3 W m-2 UV-B. Results indicate that both nitric oxide (NO) and flavonoids are systemically induced in UV-B-irradiated maize seedlings. Maize leaves pre-treated with the specific NO scavenger cPTIO, do not accumulate NO and flavonoids in response to UV-B. Whereas NO and flavonoids are accumulated in the mesophyll cells near to the leaf side receiving the UV-B irradiation, they are distributed in all tissues displaying the systemic response. Flavonoids and NO co-localize in UV-B irradiated maize leaves analyzed by images from epifluorescence microscopy. Chalcone synthase (CHS) and chalcone isomerase (CHI) genes are involved in the flavonoid biosynthetic pathway and their expression is systemically induced by UV-B in a NO dependent pathway. Finally, a functional approach demonstrates that maize leaves expressing the systemic response to UV-B show low cellular damage measured as ion  leakage when they are challenged by a second round of irradiation.","palabras_clave":"flavonoids|nitric oxide|systemic response|UV-B"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88295,"idioma_id":4,"titulo":"Catalytic upgrading of levulinic acid to ethyl levulinate using re-usable silica-included Wells-Dawson heteropolyacid as catalyst","resumen":"In this paper we report, for the first time, the direct incorporation of   a heteropolyacid (HPA) with Wells-Dawson structure during the synthesis   of silica by the sol\u2013gel technique, in acidic media, using tetraethyl   orthosilicate. The catalyst characterization was carried out by 31P MAS-NMR, FT-IR, XRD, N2 adsorption\u2013desorption measurements, and the acidic properties were determined through potentiometric titration with n-butylamine.   The synthesized catalysts were used in the esterification of levulinic   acid with ethanol, at 78&nbsp;°C, to obtain ethyl levulinate. The synthesis   of silica-included HPAs was satisfactory, and the samples kept their HPA   structure intact after synthesis. The catalytic tests for the   esterification reaction between levulinic acid and ethanol to produce   ethyl levulinate have shown that the silica-included Wells-Dawson HPA is   an active and selective catalyst for this reaction. It must be noted   that silica-included HPAs also kept their structure and catalytic   activity after three consecutive reaction cycles. These results   indicated that these solid acids are promissory catalysts for the   esterification reaction of levulinic acid and ethanol to ethyl   levulinate.","palabras_clave":"Ethyl levulinate production  |Wells-Dawson heteropolyacid incorporated in silica|Heterogeneous catalysis|Upgrading of levulinic acid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88296,"idioma_id":4,"titulo":"Entomopathogenic fungi from Argentina for the control of Schistocerca cancellata (Orthoptera: Acrididae) nymphs: fungal pathogenicity and enzyme activity","resumen":"The South American locust Schistocerca cancellata (Serville) was the most seriousagricultural pest in Argentina during the first half of the last century and remainsas a threat when preventive control measures are relaxed in the outbreak area.In this study, we analysed in the laboratory, the effectiveness of 26 fungal strains(isolated from both insects and soil collected in Argentina) for S. cancellata controland determined the relationship between the chitinase, protease and lipase levels inthese fungi and their insecticidal activities. We observed that Beauveria bassianaSchistocerca cancellata (Serville) was the most seriousagricultural pest in Argentina during the first half of the last century and remainsas a threat when preventive control measures are relaxed in the outbreak area.In this study, we analysed in the laboratory, the effectiveness of 26 fungal strains(isolated from both insects and soil collected in Argentina) for S. cancellata controland determined the relationship between the chitinase, protease and lipase levels inthese fungi and their insecticidal activities. We observed that Beauveria bassianaS. cancellata controland determined the relationship between the chitinase, protease and lipase levels inthese fungi and their insecticidal activities. We observed that Beauveria bassianaBeauveria bassiana(isolate LPSC 1067) caused the highest mortality (9091.03%), the highest valuesof chitinolytic, proteolytic and lipolytic activity were 6.1390.05, 2.5690.11 and2.3390.47, respectively, and the lowest median lethal time was 5.96 days. This isthe first time that a wide variability in chitinase, protease and lipase activity aswell as in virulence has been reported in a representative sample of differententomopathogenic fungal strains from Argentina.91.03%), the highest valuesof chitinolytic, proteolytic and lipolytic activity were 6.1390.05, 2.5690.11 and2.3390.47, respectively, and the lowest median lethal time was 5.96 days. This isthe first time that a wide variability in chitinase, protease and lipase activity aswell as in virulence has been reported in a representative sample of differententomopathogenic fungal strains from Argentina.90.05, 2.5690.11 and2.3390.47, respectively, and the lowest median lethal time was 5.96 days. This isthe first time that a wide variability in chitinase, protease and lipase activity aswell as in virulence has been reported in a representative sample of differententomopathogenic fungal strains from Argentina.90.47, respectively, and the lowest median lethal time was 5.96 days. This isthe first time that a wide variability in chitinase, protease and lipase activity aswell as in virulence has been reported in a representative sample of differententomopathogenic fungal strains from Argentina.","palabras_clave":"Schistocerca cancellata|locust|entomopathogenic fungi|biocontrol|enzyme activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88297,"idioma_id":4,"titulo":"Pathogenic and enzyme activities of the entomopathogenic fungus Tolypocladium cylindrosporum (Ascomycota: Hypocreales) from Tierra del Fuego, Argentina","resumen":"Tolypocladium cylindrosporum is an entomopathogenic fungi that has been studied as a biologicalcontrol agent against insects of several orders. The fungus has been isolated from the soil as well as from insectsof the orders Coleoptera, Lepidoptera, Diptera and Hymenoptera. In this study, we analyzed the ability of astrain of T. cylindrosporum, isolated from soil samples taken in Tierra del Fuego, Argentina, to produce hydrolyticenzymes, and to study the relationship of those activities to the fungus pathogenicity against pest aphids.We have made the traditional and molecular characterization of this strain of T. cylindrosporum. The expressionof hydrolase activity in the fungal strain was estimated at three incubation temperatures (4ºC, 12ºC and 24ºC),on different agar media supplemented with the following specific substrates: chitin azure, Tweenis an entomopathogenic fungi that has been studied as a biologicalcontrol agent against insects of several orders. The fungus has been isolated from the soil as well as from insectsof the orders Coleoptera, Lepidoptera, Diptera and Hymenoptera. In this study, we analyzed the ability of astrain of T. cylindrosporum, isolated from soil samples taken in Tierra del Fuego, Argentina, to produce hydrolyticenzymes, and to study the relationship of those activities to the fungus pathogenicity against pest aphids.We have made the traditional and molecular characterization of this strain of T. cylindrosporum. The expressionof hydrolase activity in the fungal strain was estimated at three incubation temperatures (4ºC, 12ºC and 24ºC),on different agar media supplemented with the following specific substrates: chitin azure, TweenT. cylindrosporum, isolated from soil samples taken in Tierra del Fuego, Argentina, to produce hydrolyticenzymes, and to study the relationship of those activities to the fungus pathogenicity against pest aphids.We have made the traditional and molecular characterization of this strain of T. cylindrosporum. The expressionof hydrolase activity in the fungal strain was estimated at three incubation temperatures (4ºC, 12ºC and 24ºC),on different agar media supplemented with the following specific substrates: chitin azure, TweenT. cylindrosporum. The expressionof hydrolase activity in the fungal strain was estimated at three incubation temperatures (4ºC, 12ºC and 24ºC),on different agar media supplemented with the following specific substrates: chitin azure, Tween®20, casein,and urea for chitinase, lipase, protease, and urease activity, respectively. The hydrolytic-enzyme activity wasestimated qualitatively according to the presence of a halo of clarification through hydrolase action, besides wasexpressed semi-quantitatively as the ratio between the hydrolytic-halo and colony diameters. The pathogenicityof the fungus was tested on adults of the aphid Rhopalosiphum padi at three temperatures of incubation (4ºC,12ºC and 24ºC). The suspension was adjusted to a concentration of 1x10Rhopalosiphum padi at three temperatures of incubation (4ºC,12ºC and 24ºC). The suspension was adjusted to a concentration of 1x107conidia\/ml. In pathogenicity assaysat seven days post-inoculation, the fungus caused the mortality of adults of Ropalosiphum padi at differenttemperatures also showed a broad ability to grow on several agar-culture media, supplemented with differentcarbon sources at the three incubation temperatures tested. Although, the growth was greater with higher incubationtemperatures (with maximum levels at 24°C), the fungus reached similar colony diameters after 15 daysof incubation on the medium supplemented with Tween® 20 at the lower two incubation temperatures of 4°C or12°C. In accordance with the results on colony diameters, the fungus revealed an ability to degrade casein, chitinderivatives, Tween® 20, and urea as evidenced by the appearance of a halo around the fungal colony. Becauseof its origin and temperature tolerance, this Argentine strain has great potential for use as a biocontrol agent forinsect pest control in cold and temperate environmentsRopalosiphum padi at differenttemperatures also showed a broad ability to grow on several agar-culture media, supplemented with differentcarbon sources at the three incubation temperatures tested. Although, the growth was greater with higher incubationtemperatures (with maximum levels at 24°C), the fungus reached similar colony diameters after 15 daysof incubation on the medium supplemented with Tween® 20 at the lower two incubation temperatures of 4°C or12°C. In accordance with the results on colony diameters, the fungus revealed an ability to degrade casein, chitinderivatives, Tween® 20, and urea as evidenced by the appearance of a halo around the fungal colony. Becauseof its origin and temperature tolerance, this Argentine strain has great potential for use as a biocontrol agent forinsect pest control in cold and temperate environments® 20 at the lower two incubation temperatures of 4°C or12°C. In accordance with the results on colony diameters, the fungus revealed an ability to degrade casein, chitinderivatives, Tween® 20, and urea as evidenced by the appearance of a halo around the fungal colony. Becauseof its origin and temperature tolerance, this Argentine strain has great potential for use as a biocontrol agent forinsect pest control in cold and temperate environments® 20, and urea as evidenced by the appearance of a halo around the fungal colony. Becauseof its origin and temperature tolerance, this Argentine strain has great potential for use as a biocontrol agent forinsect pest control in cold and temperate environments","palabras_clave":"Biological control|chitinolytic activity|entomopathogenesis|hydrolases|soil microorganisms|Tolypocladium cylindrosporum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88298,"idioma_id":4,"titulo":"THE GARNET -PHOSPHATE BUFFER IN PERALUMINOUS GRANITIC MAGMAS: A CASE STUDY FROM PEGMATITES IN THE POCHO DISTRICT, CÓRDOBA, ARGENTINA","resumen":"Members of the beusite\u2013graftonite series [Mn\/(Mn+Fe) between 0.47 and 0.65] appear associated to P-bearing garnet (up to 1.10 wt.% P2O5 in the crystal cores) in two primitive pegmatites of the Pocho district, Córdoba, central Argentina. Elemental maps and electron-microprobe analyses show that garnet has an irregular P distribution, with depleted rims. Textural features of garnet (resorbed margins, isolated relics in beusite, truncated zoning) and similar Mn\/Fe values in garnet and beusite indicate that the phosphate formed by destabilization of garnet. The crystallization temperatures of the zones where garnet + beusite occur are 420°C (Tablada I) and 522°C (Cerro Moreno), and the P2O5 content in the melt of the middle intermediate zone at Tablada I is 0.82\u20130.91 wt.% (estimated using P in feldspars). One possible explanation involves the onset of garnet crystallization before the nucleation of beusite, while the P content of the magma was not buffered. As magmatic evolution progressed, P content increased and eventually reached levels high enough to stabilize mafic phosphates. For some time garnet co-crystallized with beusite; this is reflected by P-depleted zones in garnet. With P build-up, eventually mafic silicates became unstable and were replaced by phosphates. The low activities of F, Li and Na contributed to stabilize beusite. The modest degree of evolution of the pegmatites is indicated by very high Mg content of the phosphates. Beusite has primary inclusions of Mg-rich phosphates, one belonging to the alluaudite group and the other one possibly belonging to the triplite or wolfeite groups. Breakdown of beusite under oxidizing hydrothermal conditions produced, among others, mitridatite and jahnsite-(CaMnMg).","palabras_clave":"beusite-graftonite|garnet|phosphorus|alluaudite group"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88299,"idioma_id":4,"titulo":"Behavioral strategies of phorid parasitoids and responses of their hosts, the leaf-cutting ants","resumen":"Host-searching and oviposition behaviors of parasitoids, and defensive responses of the hosts, are fundamental in shaping the ecology of host-parasitoid interactions. In order to uncover key behavioral features for the little known interactions between phorid parasitoids (Diptera: Phoridae) and their leaf-cutting ant hosts (Formicidae: Attini), host-related behavioral strategies (i.e., host searching and oviposition) for 13 phorid species, and host defensive responses (i.e., hitchhikers and particular body postures) for 11 ant species, were studied. Data was collected at 14 localities, one of them characterized by its high species richness for this host-parasitoid system. Phorid species showed both great variation and specificity in attacking behaviors. Some chose their hosts using either an ambush or an actively searching strategy, while some species attacked ants on different body parts, and specialized on ants performing different tasks, such as when ants were foraging, removing wastes to refuse piles, or repairing the nest. Combining all the behaviors recorded, most phorid species differed in performance in at least one, making it possible to recognize species in the field through their behavior. Phorid species that attacked hosts with greater activity levels showed overall higher attack rates, although there was no significant correlation between attack rates by most phorid species and ant activity outside the nest while parasitoids were attacking. The presence of phorids was a significant determinant for the presence of defensive behaviors by the ants. Although ant species varied in the incidence levels of these defensive behaviors, most ant species reacted against different phorids by utilizing similar behaviors, in contrast to what parasitoids do. General features of the observed phorid-ant interactions were parasitoid specialization and corresponding high interspecific variation in their behaviors, while their hosts showed generalized responses to attacks with high intraspecific variation. Behavioral patterns as well as specific features of these ant-parasitoid interactions are described, and their ecological importance discussed.","palabras_clave":"ACROMYRMEX|ATTA|APOCEPHALUS|EIBESFELDTPHORA|MYRMOSICARIUS|NEODOHRNIPHORA|HITCHHIKERS|REFUSE PILES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88300,"idioma_id":5,"titulo":"La diabetes altera el potencial osteogénico de células  progenitoras de médula ósea. Efectos del tratamiento  con metformina","resumen":"En este trabajo, estudiamos el efecto de una Diabetes inducida por destrucción parcial de la masa de células beta pancreáticas, sobre el compromiso osteogénico de células progenitoras de médula ósea (CPMO), y su modulación por el tratamiento oral con Metformina. Para ello utilizamos ratas Sprague Dawley, divididas en cuatro grupos: controles [C], controles tratadas con Metformina [M], diabéticas [D], y diabéticas tratadas con Metformina [DM]. La inducción de Diabetes se realizó, por inyección intraperitoneal sucesiva de ácido nicotínico y streptozotocina. Sobre los cultivos de CPMO se evaluó la actividad específica de Fosfatasa Alcalina (FAL) y la producción de Colágeno tipo 1 (Col-1) en estado basal y en medio de diferenciación osteogénico luego de 15 días. A los 21 días, se evaluaron los depósitos de mineral extracelular. La FAL y el Col-1 de CPMO basales, no mostraron diferencias significativas entre los cuatro grupos experimentales. Al cabo de 15 días,las CPMO de ratas M mostraron un incremento en el Col-1 de 122 % respecto de C; D 30 % respecto de C   y DM 68 % respecto de C. La FAL expresó un 171 % para M, 34 % para D; y 125 % para DM todos respecto de C. Luego de 21 días, se observó una disminución en la mineralización de las CPMO de D (65 % respecto   del grupo C). El tratamiento con metformina incrementó la mineralización de las CPMO en todos los casos. En conclusión, en nuestro modelo experimental de Diabetes, ésta disminuye el potencial osteogénico de las   CPMO, un efecto que es parcialmente revertido por el tratamiento oral con Metformina. Estos hallazgos podrían explicar, al menos en parte, las alteraciones óseas descriptas en el hueso asociadas con la Diabetes","palabras_clave":"diabetes mellitus|células progenitoras de médula ósea|hueso| metformina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88301,"idioma_id":4,"titulo":"New determination of the adiabatic ionization potential of the BaOH radical from laser photoionization-molecular beam experiments and ab initio calculations","resumen":"&nbsp;The adiabatic ionization potential of the BaOH radical, as generated in a laser vaporization-  supersonic expansion source has been determined by laser photoionization experiments to be (4.55  ± 0.03) eV. This value supports the three lowest out of seven previous experimental estimates, the   former ranging from 4.35 to 4.62 eV. The present result is compared to ab initio calculations, as   performed using both quantum chemistry at different levels of theory and density functional theory,  and trying several effective core potentials and their accompanying basis sets for Ba. The most satisfactory  agreement is obtained for either the adiabatic or vertical ionization potentials that derive  from post-Hartree-Fock [MP2 and CCSD(T)] treatments of electron correlation, along with consideration  of relativistic effects and extensive basis sets for Ba, in both BaOH and BaOH+. Such conclusions   extend to the results of related calculations on the Ba&#8722;OH dissociation energies of BaOH   and BaOH+, which were performed to help in calibrating the present computational study. Bonding   in BaOH\/BaOH+, as well as possible sources of discrepancy with previous experimental determinations   of the BaOH adiabatic ionization potential are discussed.","palabras_clave":"Laser photoionization|Adiabatic ionization potential|Alkaline-earth containing radicals|Ab initio calculations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88302,"idioma_id":4,"titulo":"Photoionization and ab initio study of Ba(H2O)n (n = 1 - 4) clusters","resumen":"An experimental and theoretical study of the photoionization energies (IE?s) of Ba(H2O)n clusters containing up to n = 4 water molecules has been performed. The clusters were generated by a pick-up source combining laser vaporization with pulsed supersonic expansion, and then photoionized by radiation of 272.5?340 nm. The experimentally determined IEe?s for n = 1 to 4 are 4.56  0.05, 4.26  0.05, 3.90  0.05 and 3.71  0.05 eV. This cluster size dependence of IE is reproduced within 0.06 eV employing the mPW1PW91 density-functional and CCSD(T, Full) quantum-chemical methods combined with the 6-311++G(d,p) basis set for the H and O atoms and three different relativistic effective core potentials for Ba atoms. The calculations indicate that the lowest energy hydration structures represent the most relevant contributions to both the vertical and adiabatic ionization energies. Experimental and theoretical evidence correlates with the progressive surface-delocalization of the electron from the hydration cavity around the Ba atom and suggests that the intra-cluster electron transfer is possible even for small aggregates.","palabras_clave":"CLUSTERS|IONIZATION POTENTIAL|SOLVATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88303,"idioma_id":4,"titulo":"Effects of gene flow from IMI resistant sunflower crop to wild Helianthus annuus populations","resumen":"Wild sunflower, H. annuus ssp. annuus, is an invasive species widely distributed in several regions of the world, including central Argentina where it shares a large area with domesticated sunflower. The discovery of imidazolinone resistance in a wild sunflower population allowed the development of Clearfield®technology in cultivated sunflower. This technology was rapidly adopted in Argentina but the trait could possibly be transferred to the naturalized wild populations through natural hybridization. The aim of this study was to evaluate the transfer of IMI resistance to wild sunflower populations and its effect on wild plants\u2019 fitness. Plants of five wild populations and their progenies of crosses with an IMI-resistant hybrid were evaluated through a dormancy, herbicide resistance, and SSR markers study. Relative fitness was compared in the five populations, F1s and backcrosses with wild and crop parental plants. Hybridization with an IMI-resistant hybrid did not alter seed dormancy. F1 individuals were more resistant to imazapyr than their wild ancestors but less tolerant than the commercial variety. SSR markers confirmed the transfer of resistance&nbsp;and identified resistant plants within the wild populations. Fitness was reduced in the first generation after crossing but was recovered in the following generations. Thus, to ensure durability and efficiency of Clearfield® technology, management practices like crop rotation and herbicide usage with different modes of action should be considered.","palabras_clave":"imidazolinone herbicides|sunflower|transference|dormancy|fitness"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88304,"idioma_id":4,"titulo":"Seasonal variations in size, biomass and elemental composition (CHN) of Halicarcinus planatus (Brachyura, Hymenosomatidae) larvae from the Beagle Channel, southern South America.","resumen":"The crab Halicarcinus planatus is the only member of the familiy Hymenosomatidae thatinhabits the southern tip of South America, and it is the only decapod species that reproducestwice a year in the Beagle Channel. In this study, we analysed seasonal variations indevelopment duration, body size, biomass (dry weight), and elemental composition (CHN) oflarvae from a population living at the southernmost limit of the species geographic range.Compared to offspring produced in December (early summer), larvae released in August (latewinter) were on average larger and heavier, and they showed a higher carbon content(suggesting a larger lipid fraction). This pattern of intraspecific variation in larval size andbiomass corresponds with minimum primary productivity in Subantarctic regions duringwinter, suggesting that large winter eggs may represent a reproductive adaptation to a regularpattern of variation in nutritional conditions, including food limitation in winter. As anadditional or alternative explanation, also strong salinity fluctuations occurring in summermight reduce larval quality in the December cohort. In conclusion, seasonal variation inlarval size and biomass may be related to variations in nutritional and\/or physical factors.","palabras_clave":"reproductive strategies|multiple spawning|larval development|sub-Antarctic waters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88305,"idioma_id":4,"titulo":"Pelagic swarms and beach strandings of the squat lobster Munida gregaria (Anomura: Munididae) in the Beagle Channel, Tierra del Fuego","resumen":"The present article is the first formal record of pelagic swarms and beach strandings of the squat lobster Munida gregaria in the Beagle Channel, southern South America. To describe size composition and natural diet of beach strandings and swarms, samples from strandings were taken in April 2007, March 2008 and March 2010. Samples from swarms were taken in May 2007 and April 2010. Also, during November 2008 and January 2009, two acoustic surveys were carried out to describe both, horizontal distribution and school metrics of swarms. Pelagic swarms and beach strandings were composed of 100% individuals of the morph gregaria of M. gregaria. Mean size of males and females in both, beach strandings and swarms, were similar. The diet of pelagic M. gregaria was composed mainly of crustaceans, unicellular algae and small macroalgae, sediment and particulate organic matter. Swarms of pelagic Munida took the shape of extended layers of varying density and height. Their positions in the water column were also variable: swarms were found at different depths, from the subsurface layer to near the sea bottom. Occasionally, some large swarms occupied most of the water column. In the Beagle Channel, SW winds during spring tides could be a forcing factor for M. gregaria strandings. The absence of shoaling animals in the Beagle Channel between 1997 and 2002 and the recent occurrence of swarms are coincident with their appearance in other locations in Patagonia. In consequence, we hypothesize that the factor influencing the formation of swarms must be acting at a regional scale.","palabras_clave":"Krill|Shoals|Sub-Antarctic|Distribution|Hydroacoustic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88306,"idioma_id":4,"titulo":"Graft Copolymers for Blend Compatibilization. Mathematical Modeling of the Grafting Process","resumen":"In the present work, we study the process of grafting of polyethylene (PE) onto polystyrene (PS) through a Friedel-Crafts reaction, which results in a mixture of PE-g-PS copolymer, unmodified PE, and modified PS. The formed copolymer may be suitable for compatibilization of immiscible mixtures in the household plastic waste stream, where PE and PS are majority components. Since the compatibilization effect depends on the composition and block lengths in the graft copolymer we present a model for predicting the complete molecular weight distribution of the homopolymers, and the chemical composition distribution of the graft copolymer, using for this purpose probability generating functions. The resulting model has potential for its application in an optimization tool for the compatibilization process, as it is able to account for the opposing effects of competing reactions that characterize the studied graft reaction","palabras_clave":"MODELING|GRAFT COPOLYMER|MOLECULAR WEIGHT DISTRIBUTION|CHEMICAL COMPOSITION DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88307,"idioma_id":4,"titulo":"Lessons from multi-decadal oceanographic monitoring at an estuarine ecosystem in Argentina","resumen":"Both climate change and anthropogenic impact are creating a dynamic of continuous changes in  ecosystems. While the expected consequences of these changes are global, the occurrence of extreme events  and specific environmental problems are usually local or regional phenomenon. In particular, the coastal  ecosystems are among the first vulnerable areas to show those changes; in spite of this, are the least studied.  The Bahia Blanca estuary, Argentina, is located at 38º 40´ S and 62º 09´ W with an area of 2300 km2. Along the  northern shore of the estuary it is found the most important deepwater harbor of the country, where most of  the agricultural and industrial products are exported. For the first time, based on multi decadal oceanographic  monitoring and meteorological data of this ecosystem, a co-relational analysis approach was outlined considering  several documented changes at various trophic levels; namely, phytoplankton and zooplankton assemblages,  commercial crustaceans and fisheries. As results, several novel emerging hypotheses regarding cause-andeffect  relationships were formulated. These unprecedented findings represent substantial information for the  focus of the future ecosystem management and research, revealing gaps in the present knowledge of the coastal  ecosystem which can be extrapolated to other worldwide coastal systems.","palabras_clave":"Long-term oceanographic monitoring|temperature|salinity|phytoplankton"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88308,"idioma_id":4,"titulo":"Revision and phylogenetic analysis of the spider genus Philisca Simon (Araneae: Anyphaenidae, Amaurobioidinae)","resumen":"We review the spider genus Philisca Simon, an endemic of the southern forests in Chile and Argentina, and present a phylogenetic analysis including 15 species, of which five are newly described (P. atrata, P. robinson, P. viernes, P. pizarroi and P. robusta), together with other 98 representatives of the family Anyphaenidae. Four species names are considered nomina dubia (Clubiona gayi Nicolet, Drassus mirandus Nicolet, Clubiona altiformis Nicolet, P. obscura Simon). Cluilius chilensis Mello-Leitão is a newly synonymized with P. accentifera Simon. The phylogenetic analysis resulted in P. puconensis Ramírez branching off basally in the genus, because of its numerous leg spines and unmodified male chelicerae, all plesiomorphic for the group; the remaining species form two clear groups. The first one, formed by P. hahni Simon, P. tripunctata (Nicolet), P. amoena (Simon), P. hyadesi (Simon) and P. doilu (Ramírez), are grouped by the loss of spines on legs I and II. The second, formed by P. huapi Ramírez, P. ingens Berland, P. ornata Berland, P. accentifera Simon, P. atrata and four new species endemic to the Robinson Crusoe Island in the Juan Fernández Archipelago, have the male chelicerae, and in most cases also the endites, modified. In total, six species of Philisca are endemic to Juan Fernández, but our dataset is not conclusive for the distinction of alternative colonization scenarios. We analyze the evolution of leg macrosetae, and show two independent instances of reduction of spination, one on the continent and another on the Juan Fernández islands.","palabras_clave":"SOUTH AMERICA|ROBINSON CRUSOE|JUAN FERNANDEZ|ISLAND BIOGEOGRAPHY|SYSTEMATICS|CLADISTICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88309,"idioma_id":4,"titulo":"Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype","resumen":"Autoantibodies  to zinc transporter 8 (ZnT8A) constitute an additional marker of  autoimmune diabetes, complementing those already used in diagnosis  support.ZnT8A  could also  be found in latent autoimmune diabetes of adults (LADA). The aim of  this study was to evaluate the prevalence of ZnT8A in adult-onset  diabetic patients in Argentinian population. A total of 271 patients  with diagnosis of diabetes at mean  age 53.4&nbsp;±&nbsp;10.9, body mass index &#8804; 30, without  insulin treatment for the first year of disease, and initially  classified as type 2 diabetic patients, were tested for ZnT8A  using cDNA plasmids encoding the C-terminal domains (aa268-369)  carrying 325Arg, 325Trp and a dimeric cDNA construct carrying both  325Arg and 325Trp (ZnT8 Arg-Trp325). We also analyzed proinsulin  autoantibodies (PAA), glutamic  acid decarboxylase autoantibodies (GADA) and protein tyrosine  phosphatase IA-2 autoantibodies (IA-2A). A subset of 101 patients was  followed during 6 years in order to analyze insulin requirement. Out  of  the 271 patients,22.1%  presented at least one humoral marker, 2.6% were PAA+, 12.5% were  GADA+, 3.3% were IA&nbsp;2A+ and 10.7% were ZnT8A+. Among these  latter, 7.0% were ZnT8A&nbsp;Arg325, 51.7% were ZnT8A-Trp325 and  62.1% were ZnT8A-Arg-Trp325.  Furthermore, the prevalence of autoantibodies in the group of  patients treated with insulin (n=18) was 55.6%. These  results demonstrated that a significant proportion of autoimmune  adult-onset diabetic patients presented ZnT8A as the only humoral  marker. Between them, the higher prevalence was for ZnT8A-Trp325. We  suggest that screening for LADA patients, best performed with a  minimal set of marker determination, must include at least the  screening of GADA and ZnT8A-Arg-Trp325.","palabras_clave":"Zinc transporter 8|humoral immune response|adult-onset diabetes mellitus|Zn T8A prevalence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88310,"idioma_id":5,"titulo":"Estudios recientes en zooarqueología latinoamericana: selección de trabajos del IICNZA","resumen":"En las últimas décadas, la zooarqueología argentina ha mostrado un acelerado crecimiento que se aprecia no sólo en el número de profesionales dedicados a esta disciplina, sino también en la diversidad de tópicos abordados. El II Congreso Nacional de Zooarqueología Argentina (IICNZA), celebrado en Olavarría (provincia de Buenos Aires) entre el 9 y el 13 de Mayo de 2011, organizado por la Facultad de Ciencias Sociales (UNCPBA), constituyó un evento apropiado para dar a conocer los nuevos resultados relacionados con distintos temas zooarqueológicos propios de las diferentes regiones de nuestro país y Latinoamérica. Además, este encuentro permitió discutir la implementación de viejas y nuevas metodologías y generar un espacio de interacción interdisciplinaria en torno a la investigación de los materiales faunísticos. En el IICNZA se desarrollaron seis simposios, una sesión general y una mesa de pósters. En esta última fueron presentados 25 trabajos, los cuales abarcaron una gran diversidad de temas en diferentes regiones de la Argentina y otros países de América Latina.","palabras_clave":"Zooarqueología latinoamericana|II Congreso Nacional de Zooarqueología Argentina|Estudios recientes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88311,"idioma_id":4,"titulo":"Analytical models of soil and litter decomposition: Solutions for mass loss and time-dependent decay rates","resumen":"Combining decomposition data with process-based biogeochemical models is essential to quantify the  turnover of organic carbon (C) in surface litter and soil organic matter (SOM). Long-term decomposition  may be suitably analyzed by linear models (i.e., all &#64258;uxes de&#64257;ned by &#64257;rst-order kinetics), which allow the  derivation of analytical expressions to estimate the loss of C and the overall apparent decay rate (kapp)  through time. Here we compare eight linear models (four discrete-compartment models with one or two  C pools, two models with a single time-dependent decay rate, and two models based on a continuous  distribution of decay rates) and report their analytical solutions for two types of decomposition experiments: i) studies that evaluate the decomposition of a single input of fresh litter (i.e., a single cohort, as  in litterbag and C labeling experiments), and ii) studies that evaluate the decomposition of soil samples  with compounds of different ages (i.e., multiple cohorts, as in long-term incubations or isotope dilution  experiments). We &#64257;tted analytical mass loss functions to both types of datasets and evaluated the  performance of the models. For single-cohort data, continuous-decay models provide the best balance  between accuracy and parsimony (R  2  ¼ 0.99, lowest Akaike and Bayesian information criteria), while for  multiple-cohort data the two-pool models tend to perform better (R  2  ¼ 0.96), perhaps because of the  strong separation of time scales in the decomposition data considered. Differences among some models  are marginal, suggesting that decomposition data alone do not point to a single \u2018best\u2019 model. All models  resulted in apparent decay rates that decreased markedly through time, in contrast with the assumption  of constant k adopted in the single-pool exponential decay model. We also show how model parameters  estimated from single cohort samples can be used to model multiple cohort decomposition, unifying  both types of experimental data in one theory. Based on our results, it is possible to distinguish the  temporal changes in C loss that are attributable to initial chemical composition or abiotic factors, from  those associated with the presence of multiple ages in the substrate.","palabras_clave":"Soil organic matter|litter decomposition|Carbon model|Apparent decay rate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88312,"idioma_id":4,"titulo":"Shifts in soil organic carbon for plantation and pasture establishment in native forests and grasslands of South America","resumen":"The replacement of native vegetation by pastures or tree plantations is increasing worldwide. Contradictory effects ofthese land use transitions on the direction of changes in soil organic carbon (SOC) stocks, quality, and vertical distribution have been reported, which could be explained by the characteristics of the new or prior vegetation, time sincevegetation replacement, and environmental conditions. We used a series of paired-&#64257;eld experiments and a literaturesynthesis to evaluate how these factors affect SOC contents in transitions between tree- and grass-dominated (grazed)ecosystems in South America. Both our &#64257;eld and literature approaches showed that SOC changes (0\u201320 cm of depth)were independent of the initial native vegetation (forest, grassland, or savanna) but strongly dependent on the characteristics of the new vegetation (tree plantations or pastures), its age, and precipitation. Pasture establishmentincreased SOC contents across all our precipitation gradient and C gains were greater as pastures aged. In contrast,tree plantations increased SOC stocks in arid sites but decreased them in humid ones. However, SOC losses in humidsites were counterbalanced by the effect of plantation age, as plantations increased their SOC stocks as plantationsaged. A multiple regression model including age and precipitation explained more than 50% (p < 0.01) of SOCchanges observed after sowing pastures or planting trees. The only clear shift observed in the vertical distribution ofSOC occurred when pastures replaced native forests, with SOC gains in the surface soil but losses at greater depths.The changes in SOC stocks occurred mainly in the silt+clay soil size fraction (MAOM), while SOC stocks in labile(POM) fraction remained relatively constant. Our results can be considered in designing strategies to increase SOCstorage and soil fertility and highlight the importance of precipitation, soil depth, and age in determining SOCchanges across a range of environments and land-use transitions.","palabras_clave":"soil organic matter|rainforests|land use transitions|vegetation replacement|mean annual precipitation|plantation age"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88313,"idioma_id":4,"titulo":"Gestational restraint stress and the developing dopaminergic system: An overview","resumen":"Prenatal stress exerts a strong impact on fetal brain development in rats impairing adaptation to stressful conditions, subsequent vulnerability to anxiety, altered sexual function, and enhanced propensity to self-administer drugs. Most of these alterations have been attributed to changes in the neurotransmitter dopamine (DA). In humans; dysfunction of dopaminergic system is associated with development of several neurological disorders, such as Parkinson disease, schizophrenia, attention-deficit hyperactivity disorder, and depression. Evidences provided by animal research, as well as retrospective studies in humans, pointed out that exposure to adverse events in early life can alter adult behaviors and neurochemical indicators of midbrain DA activity, suggesting that the development of the DA system is sensitive to disruption by exposure to early stressors. The purpose of this article is to provide a general overview of published studies and our own study related to the effect of prenatal insults on the development of DA metabolism and biology, focusing mainly in articles involving prenatal-restraint stress protocols in rats. We will also attempt to make a correlation between theses alterations and DA-related pathological processes in humans.","palabras_clave":"STRESS PRENATAL|LIMBIC SYSTEM|RESTRAINT |DOPAMINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88314,"idioma_id":4,"titulo":"Calcareous chitin: A novel low-cost sorbent for cadmium (II)","resumen":"This research focuses on the study and proposal of a new low-cost porous sorbent named calcareous chitin (CaCh). The CaCh is prepared by alkaline treatment of crustacean exoskeleton to produce a porous matrix of chitin and calcium carbonate without original proteins. Characterization using SEM-EDX, X-ray, FT-IR and studies to reveal adsorptive characteristic like BET surface area measurements were made. Results demonstrated that the CaCh structure is more porous than chitin one because there are differences in the obtention method. Furthermore, adsorption studies demonstrated its capability to remove Cd(II). The adsorption isotherms could be well fitted by the Langmuir equation. The results show that due to its easy, rapid and low cost preparation added to the demonstrated adsorption characteristics calcareous chitin can be considered a low cost sorbent of heavy metals ions like Cadmium for wastewater treatment. ","palabras_clave":"CALCAREOUS CHITIN|CHITIN|SORPTION|CADMIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88315,"idioma_id":4,"titulo":"Analysis of thermal and structural parameters and microhardess variations in different Al-Cu alloys directionally solidified","resumen":"The columnar - to - equiaxed transition (CET) was investigated inAl-Cu alloys (Al-1wt%Cu, Al-4.5wt%Cu, Al-15wt%Cu and Al-33.2wt%Cu) solidified directionally from a chill face in a verticalsetup. The CET occurs when the temperature gradient in the meltahead of the columnar front reach critical values. Also, weinvestigate correlations between structural parameters (grain size)with Vickers microhardness measurements in the directionallysolidified samples. We observed that the Vickers microhardness isgreater in the equiaxed zone than in the columnar or columnar toequiaxed transition (CET) zone, additionally, is greater on theedges of the samples than in the centre. Also, we determined thatthe grain size increases from the columnar to equiaxed structure.","palabras_clave":"Solidificacion|Aeaciones Al-Cu"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88316,"idioma_id":4,"titulo":"Corrosion and Wear Resistance of Hypoeutectic Zn-Al Alloys as a Function of Structural Features","resumen":"Abstract: The aim of the present research was to investigate the role of the type of grainmacrostructure (columnar, columnar-to-equiaxed transition, CET, and equiaxed) and microstructure(secondary dendritic arm spacing) in the wear and electrochemical behavior of hypereutectic Zn-Alalloys (Zn-1wt%Al, Zn-2wt%Al, Zn-3wt%Al and Zn-4wt%Al) directionally solidified in a verticalupward directional solidification device. The results obtained in this alloy system indicate that thecorrosion resistance increases with the concentration of aluminum, but even at the highestconcentrations depends on the structure. The microstructure (smaller grain size and secondarydendritic arm spacing) for the columnar structure increases the susceptibility to corrosion. For thesame wear conditions, the wear rate of the equiaxed region is lower than the columnar and transitionregions. Independently of the type of structure the wear resistance increases with the aluminumconcentration. For each alloy concentration, the wear resistance increases from the columnar to theequiaxed structure. A clear inverse relation is observed between the wear resistance and thesecondary dendritic arm spacing, which may explain the increase in wear resistance in the equiaxedregion. At low spacings, the wear rate converges to a single value","palabras_clave":"Solidificación|Wear|Corrosión"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88317,"idioma_id":4,"titulo":"Modeling the interaction of convex solidifying interfaces with spherical particles","resumen":"The phenomenon of pushing during the solidification is modeled for the case of particles generating a convex interface. Thermal and fluid fields are calculated in a decoupled way determining in first place the shape of the interface and then, the two main forces acting during pushing; the drag and repulsion forces. The thermal and fluid flow fields were calculated using finite element methods.Both, the drag and repulsion forces are integrated at each step and compared until both are equal and the steady state of pushing is reached. The repulsion force is integrated using the Casimir-Lifshitz-Van der Waals interaction. It was found that the model predicts the equilibrium distance in a steady state of pushing for spherical particles and a convex solidifying interface. It is shown that the equilibrium separation distance for a convex interface results in a larger solidification velocity for trapping with respect to an ideal planar interface. The model results were in good agreement withexperimental results for the critical velocity reported in the literature&nbsp;","palabras_clave":"Solidification|Computer simulation|Fluid flows|Interfaces"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88318,"idioma_id":4,"titulo":"A numerical model study of the effect of interfac e shape on particle pushin g","resumen":"numerical model using an axi-symmetric approximation is developed to study particle pushing during solidification. The model is applied to determine the effect of different parameters on the predicted critical velocity for engulfing of the particle by the solidifying interface. The main parameters considered are particle radius, interface velocity and interface shape as obtained for different thermal conductivities between matrix and particle. The relative thermal conductivity is very important in the pushing\/capture process increasing or decreasing the critical velocity for pushing one order of magnitude, with respect to the critical velocity for a flat interface depending if the interface is concave or convex, respectively. Moreover, the predicted critical velocities cover the span of measured values in agreement with the tendency given by the thermal conductivities and particle radius.","palabras_clave":"Solidificacion|Modelización|Interacción Interfase-particula"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88319,"idioma_id":4,"titulo":"Use of Raman spectroscopy and chemometrics for the quantification of metal ions attached to Lactobacillus kefir","resumen":"Aims: To set-up an experimental and analytical methodology to evaluate the feasibility of developing simple, accurate and quantitative models based on Raman spectroscopy and multivariate analysis for the quantification of metal ions adsorbed to the bacterial surface of Lactobacillus kefir. Methods and Results: One millilitre cultures from two strains of Lact. kefir in the stationary phase were harvested and washed twice with ultra pure water. The bacterial pellets were resuspended into 1 ml solutions of Pb+2, Cd+2 or Ni+2 ranging from 0 to 0Æ9 mmol l)1. The suspensions were further incubated for 1 h at 30ºC at pH 5,5. After centrifugation, the pellets were kept to register the Raman spectra and the supernatants were used for the analytical determination of Pb+2, Cd+2 and Ni+2. Micro-organisms nontreated with metal ions were used as controls. Principal component analysis (PCA) was performed over the preprocessed Raman spectra to evaluate whether the clusters obtained could be correlated with the concentration of metal ions attached to the bacterial biomass. After that, partial least squares (PLS) models were calibrated with the aim of quantifying the metal ions adsorbed to the bacterial surface. According to the analytical determinations, the maximum binding capacity of all the metals (qmax) attained values that are comparable with those observed for other lactic acid bacteria (ca. 0,200 mmol g)1). The spectral analysis revealed that the main functional groups involved in the bacteria &#8260; metal interaction are carboxylates, phosphates and polysaccharides. In PCA, the first two principal components explain more than 72% variance of the spectral data set contained in the data structure, allowing a clear discrimination among samples of different concentrations. Based on this information and using as reference the results obtained by analytical methods, PLS prediction models were successfully defined for the quantification of Pb+2, Cd+2 and Ni+2 attached to the bacterial surface. Conclusions: The calibration and validation of methods based on multivariate analysis allowed the definition of models for the quantification of Pb+2, Cd+2 and Ni+2 attached to bacterial surfaces. The high percentages of explained variances in PCA gave a strong support to calibrate the prediction models, depicting very good correlations with the reference method (correlations 0,90 in all cases).Significance and Impact of the study: Lactobacillus kefir CIDCA 8348 and JCM 5818 bind Pb+2, Cd+2 and Ni+2 in an efficient way. This fact gives support for their potential use as sequestrants of traces of these metals in products addressed to human and animal consume. The prediction models developed would be useful for the determination of the investigated metal ions in unknown samples giving at the same time, structural information about this interaction. This is certainly the most important contribution of this work.","palabras_clave":"biosorption|metal ions|L. kefir|multivariate analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88320,"idioma_id":4,"titulo":"Lactation deficit in OFA hr\/hr rats may be caused by differential sensitivity to stress compared with Wistar and Sprague Dawley rats","resumen":"OFA hr\/hr (OFA) rats present lactation deficit. To explore whether abnormal stress responsiveness causes this deficit, we compared their hormonal (prolactin, progesterone and corticosterone) responses to stress (room change and 2 min. ether) with those of Wistar and Sprague Dawley (SD) rats during the cycle, pregnancy, lactation, after ovariectomy and ovarian steroid hormone priming and on suckling response. We also studied the hypothalamic expression of prolactin (PRLRlong) and the isoforms of progesterone (PR A and B) and estrogen (ER&#945; and &#946;) receptors in late pregnancy and the capacity of anxiolytic (diazepam) administration to improve lactation. Ether exposure increased circulating hormones in the three strains on cycling and ovariectomized rats, but was less effective in pregnancy and lactation. Elevated estrogen (estrus and estradiol-treated ovariectomized rats) potentiated prolactin response more in SD and OFA than in Wistar rats. Elevated progesterone (late pregnancy, lactation, ovariectomized-progesterone-treated rats) inhibited the response less in OFA than in SD or Wistar rats. Ether exposure inhibited the suckling response only in OFA rats. Diazepam treatment increased pup survival rate and suckling response. Hypothalamic total PR mRNA content, assayed by RT-PCR, was higher in pregnant OFA rats compared with SD and Wistar, but PRB\/PRA protein ratio, determined by Western blot was low in Wistar rats, intermediate in OFA and highest in SD rats. The heightened sensitivity to stress of lactating OFA rats may contribute to their lactational deficit and be caused by a combination of hypoprolactinemia and reduced inhibitory capacity of progesterone.","palabras_clave":"lactation|stress|prolactin|corticosterone|ovarian hormones|reproductive states"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88321,"idioma_id":4,"titulo":"TESTOSTERONE AND REPRODUCTIVE ACTIVITY IN THE MALE  TEGU LIZARD, TUPINAMBIS MERIANAE","resumen":"In this study, we examined plasma testosterone levels in male Tupinambis merianae lizards and their relation to the seasonal reproductive activities observed in this species.  We found that the highest androgen levels were associated with reproductive activity in spring, comprising sperm production, reproductive behaviors (territoriality, courtship, and matings), and secretory activities of femoral glands and kidney sexual segment.  This pattern, in which spermatogenesis and steroidogenesis is temporally coupled to reproductive behaviors, constitutes a typical associated reproductive cycle.  We observed an additional rise of testosterone in the fall that correlated with a secondary phase of testicular recrudescence, but which was not accompanied by reproductive behaviors or by secretory activities of the femoral glands and kidney sexual segment.  The absence of sperm in the seminiferous tubules and epididymis during the cold months indicates that spring matings of T. merianae, as in most lizards, are supported by prenuptial spermatogenesis.  Besides its association with high levels of circulating androgens, the spring breeding events coincide with an increase in environmental temperatures.  Both spermatogenic waves also coincide temporally with the equinoxes.  Further studies are necessary to establish the relative contributions of endocrine and environmental factors in triggering reproductive events in this species.  We believe that this second non-functional spermatogenic wave may be a remnant of an ancestral bimodal reproductive cycle in this species.","palabras_clave":"TUPINAMBIS MERIANAE|reproductive behavior|spermatogenesis|testosterone|renal sexual segment|femoral glands"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88322,"idioma_id":5,"titulo":"Recuperación estructural y funcional de los espacios entre arbustos al cabo de 10 años de exclusión del pastoreo en una estepa semiárida del noreste de la Patagonia","resumen":"En las estepas arbustivas del noreste de la Región Patagónica, el sobrepastoreo del ganado doméstico genera la formación de islas arbustivas distribuidas en una matriz degradada de suelo desnudo o con escasa cobertura vegetal. La recuperación estructural y funcional de los espacios entre arbustos mediante la remoción del ganado dependería de la magnitud de la degradación. Si el sistema ha atravesado un umbral crítico de degradación la sola remoción del disturbio no sería suficiente para revertir las alteraciones provocadas por el pastoreo. El objetivo del trabajo fue evaluar la recuperación de espacios entre arbustos en un sitio representativo del sistema en estudio luego de 10 años de exclusión del pastoreo, mediante la comparación de la cobertura y propiedades físicoquímicas del suelo entre áreas clausuradas y pastoreadas. Se realizaron mediciones en cuatro áreas clausuradas y en áreas aledañas a las mismas sometidas a pastoreo continuo. Se comparó el tamaño de los espacios entre arbustos y la cobertura (vegetación, costra biológica, broza, suelo desnudo y pavimento de erosión), textura, contenido de nutrientes y tasa de infiltración del suelo. El tamaño de los espacios entre arbustos fue mayor en las áreas pastoreadas que en las clausuradas. La cobertura aérea de gramíneas perennes y de costras biológicas fue mayor en las áreas clausuradas (27% y 45%, respectivamente) que en las pastoreadas (&lt;1% y 3%). Las propiedades físicoquímicas del suelo y la tasa de infiltración no difirieron entre las condiciones de clausura y pastoreo, excepto que la densidad aparente y el contenido de arena en la capa superficial del suelo fueron ligeramente mayores (7% y 3%, respectivamente) en las áreas pastoreadas. La sola exclusión del pastoreo por un periodo de 10 años resultó en el restablecimiento de gramíneas perennes y costras biológicas, sugiriendo que la alteración estructural y funcional de los espacios entre arbustos aún no ha superado un umbral crítico de degradación. &nbsp; ","palabras_clave":"DESERTIFICACIÓN|DEGRADACIÓN DE PASTIZALES|UMBRAL DE DEGRADACIÓN|iNFILTRACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88323,"idioma_id":4,"titulo":"Peritubular Myoid Cells from Rat Seminiferous Tubules Contain Actin and Myosin Filaments Distributed in Two Independent Layers","resumen":"In the mammalian testis, peritubular myoid cells (PM cells) surround the seminiferous tubules (STs), express cytoskeletal markers of true smooth muscle cells, and participate in the contraction of the ST. It has been claimed that PM cells contain bundles of actin filaments distributed orthogonally in an intermingled mesh. Our hypothesis is that these actin filaments are not forming a random intermingled mesh, but are actually arranged in contractile filaments in independent layers. The aim of this study is to describe the organization of the actin cytoskeleton in PM cells from adult rat testes and its changes during endothelin-1-induced ST contraction. For this purpose, we isolated segments of ST corresponding to the stages IX\u2013X of the spermatogenic cycle (ST segments), and analyzed the actin and myosin filament distribution by confocal and transmission electron microscopy. We found that PM cells have actin and myosin filaments interconnected in thick bundles (AF-MyF bundles). These AF-MyF bundles are distributed in two independent layers: an inner layer toward the seminiferous epithelium, and an outer layer toward the interstitium, with the bundles oriented perpendicularly and in parallel to the main ST axis, respectively. In endothelin-1 contracted ST segments, PM cells increased their thickness and reduced their length in both directions, parallel and perpendicular to the main ST axis. The AF-MyF bundles maintained the same organization in two layers, although both layers appeared significantly thicker. We believe that this is the first time this arrangement of AF-MyF bundles in two independent layers has been shown in smooth muscle cells, and that this organization would allow the cell to generate contractile force in two directions.","palabras_clave":"SEMINIFEROUS TUBULES|PERITUBULAR MYOID CELLS|CONTRACTION|ACTIN AND MYOSIN FILAMENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88324,"idioma_id":4,"titulo":"Non-substitutional Sn defects in Ge-(1-x)Sn_x  alloys  for opto-and nanoelectronics","resumen":"Important technological applications are envisaged for Ge1&#8722;x Snx alloys. They provide a route to obtain direct-gap group IV materials, tuneable by concentration. Therefore, these alloys are ideal candidates for optoelec-tronic devices, highly compatible with Si integrated circuits. Contrary to other binary alloys with group IV elements, homogeneous Ge1&#8722;x Snx alloys, as required for device applications, have proven difficult to form above a certain temperature-dependent critical Sn concentration. Through a detailed ab-initio local defect study, and the proposal of astatistical model for the formation of these alloys, we predicted that a new type of Sn defect (&#946;-Sn), consisting of a single Sn atom in the centre of a Ge divacancy, might be formed. The environment of this defect relaxes towards a cubic octahedral configuration, facilitating the nucleation of white tin and its segregation, as found in amorphoussamples. We confirmed that Sn would enter substitutionally in the Ge lattice, but above a temperature-dependent critical concentration, non-substitutional &#946;-Sn defects should be formed, consistent with experimental observations. In this paper we introduce a two-site substitutional equiv alent for the non-substitutional &#946;-Sn defect in Ge, as needed in order to be able to include &#946;-Sn in electronic structure calculations with effective-field electronic models for disorder, like the Virtual Crystal Approximation (VCA). The equivalent substitutional model is derived in order to takeinto account the different symmetries in the immediate environment of the substitutional &#945; and non-substitutional &#946; defect sites and their effect on the electronic structure.","palabras_clave":"OPTOELECTRONICS|ALLOYS|DEFECTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88325,"idioma_id":5,"titulo":"Primeros resultados de las investigaciones en el sitio Laguna de los Pampas (partido de Lincoln, provincia de Buenos Aires)","resumen":"En este trabajo se presentan los primeros resultados de las investigaciones efectuadas durante tareas de rescate arqueológico en la Laguna de los Pampas (Figura 1a), localizada en el sudeste del partido de Lincoln (provincia de Buenos Aires). Los restos fueron descubiertos en febrero de 2008 por el Sr. Ramón Coria, vecino de la localidad cercana de Coronel Martínez de Hoz, cuando visitó la laguna y en diciembre del mismo año, dos de los autores (GP y PM) constataron la importancia de los hallazgos y rescataron aquellos que estaban más comprometidos (e.g., los restos humanos). Posteriormente, entre febrero y marzo de 2009, se realizó una recolección superficial, se sondearon varios sectores próximos a la barranca de la laguna y se excavó un esqueleto, que fue denominado Entierro 1. La mayoría de los restos se encontraban en superficie, debido a la dinámica lagunar que provocó la erosión de las barrancas durante la crecida y la posterior reexposición cuando se redujo el cuerpo de agua.","palabras_clave":"NOROESTE DE BUENOS AIRES|LAGUNA DE LOS PAMPAS|RESTOS HUMANOS|HOLOCENO TEMPRANO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88326,"idioma_id":4,"titulo":"First isolation of Mycobacterium avium subsp Paratuberculosis from commercial pasteurized milk in Argentina.","resumen":"Mycobacterium aviumsubsp paratuberculosis was isolated from two out of seventy samples (2.86 %) of pasteurized and ultra-pasteurized milk. The isolates were positives to IS900PCR and showed a C17 RFLP pattern, the most prevalent in Argentina. The present study is the first report of Mycobacterium aviumsubsp paratuberculosisculture from pasteurized milk in Argentina. ","palabras_clave":"PARATUBERCULOSIS|MYCOBACTERIUM AVIUM SUBSP PARATUBERCULOSIS|PATEURIZED MILK|PCR IS900"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88327,"idioma_id":4,"titulo":"Growth of short cracks during low and high cycle fatigue in a duplex stainless steel","resumen":"Damage evolution during low- and high-cycle fatigue in an embrittled duplex stainless steel is characterized in this paper. Moreover, scanning electron microscopy observations (SEM) in combination with electron backscattered diffraction (EBSD) measurements and transmission electron microscopy (TEM) were employed in order to analyze microcracks formation and propagation. During low-cycle fatigue, microcracks initiate the ferrite phase either along slip planes with the highest Schmid factor (SF) inside the grains or at the alpha-alpha grain boundary. Then, microcracks propagation take place in ferrite or austenite grains with the highest SF. An analysis of the dislocation structure in the near-surface and in ferritic grains in the bulk of the specimen has shown that dislocation microbands are associated with microcrack initiation.In the high-cycle fatigue regime, damage generally initiates in the austenite by slip band formation followed by crack initiation either at an alpha-alpha boundary or at an alpha-gamma boundary in the intersection of slip bands in the austenite. The microstructure in the austenite consists of a low density of dislocation pile-ups while the ferrite is practically inactive or develops only micro-yielding at boundaries. Despite the differences in both fatigue regimes, phase boundaries are an effective barrier against crack propagation because they delay the advance of the crack tip.","palabras_clave":"LCF|DUPLEX STAINLESS STEELS|EMBRITTLEMENT|MICROSTRUCTURE|MICROCRACK NUCLEATION AND PROPAGATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88328,"idioma_id":4,"titulo":"Host Cell Factors as Antiviral Targets in Arenavirus Infection","resumen":"Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection.","palabras_clave":"ARENAVIRUS|VIRUS JUNIN|HEMORRHAGIC FEVER|ANTIVIRAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88329,"idioma_id":4,"titulo":"Signal transduction pathways in FSH regulation of rat Sertoli cell proliferation","resumen":"The final number of Sertoli cells reached during the proliferative periods determines sperm production capacity in adulthood. It is well known that FSH is the major Sertoli cell mitogen; however, little is known about the signal transduction pathways that regulate the proliferation of Sertoli cells. The hypothesis of this investigation was that FSH regulates proliferation through a PI3K\/Akt\/mTORC1 pathway, and additionally, AMPK-dependent mechanisms counteract FSH proliferative effects. The present study was performed in 8-day-old rat Sertoli cell cultures. The results presented herein show that FSH, in addition to increasing p-Akt, p-mTOR, and p-p70S6K levels, increases p-PRAS40 levels, probably contributing to improving mTORC1 signaling. Furthermore, the decrease in FSH-stimulated p-Akt, p-mTOR, p-p70S6K, and p-PRAS40 levels in the presence of wortmannin emphasizes the participation of PI3K in FSH signaling. Additionally, the inhibition of FSH-stimulated Sertoli cell proliferation by the effect of wortmannin and rapamycin point to the relevance of the PI3K\/Akt\/mTORC1 signaling pathway in the mitotic activity of FSH. On the other hand, by activating AMPK, several interesting observations were made. Activation of AMPK produced an increase in Raptor phosphorylation, a decrease in p70S6K phosphorylation, and a decrease in FSH-stimulated Sertoli cell proliferation. The decrease in FSH-stimulated cell proliferation was accompanied by an increased expression of the cyclin-dependent kinase inhibitors (CDKIs) p19INK4d, p21Cip1, and p27Kip1. In summary, it is concluded that FSH regulates Sertoli cell proliferation with the participation of a PI3K\/Akt\/mTORC1 pathway and that AMPK activation may be involved in the detention of proliferation by, at least in part, a decrease in mTORC1 signaling and an increase in CDKI expression.","palabras_clave":"FSH|PI3K\/AKT\/mTORC1|AMPK"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88330,"idioma_id":4,"titulo":"Surface Plasmon Resonance reveals a different pattern of Proinsulin Autoantibodies Concentration and Affinity in Diabetic patients","resumen":"Type 1 diabetes mellitus (DM) is characterized by autoimmune aggression against pancreatic beta cells resulting in absolute deficiency of insulin secretion. The first detectable sign of emerging autoimmunity during the preclinical asymptomatic period is the appearance of diabetes-related autoantibodies. In children at risk for type 1 DM, high-affinity Insulin autoantibodies reactive to proinsulin, are associated with diabetes risk. Autoantibodies are usually measured by radioligand binding assay (RBA) that provides quasi-quantitative values reflecting potency (product between concentration and affinity) of specific autoantibodies. Aiming to improve the characterization of the specific humoral immune response, we selected surface plasmon resonance (SPR) as an alternative method to measure proinsulin autoantibodies (PAA). This novel technology has allowed real time detection of antibodies interaction and kinetic analysis. Herein, we have employed SPR to characterize the PAA present in sera from 28 childhood-onset (mean age 8.31¡À4.20) and 23 adult-onset diabetic patients (¡Ý65 years old, BMI&lt;30) in terms of concentration and affinity. When evaluating comparatively samples from both groups, childhood-onset diabetic patients presented lower PAA concentrations and higher affinities (median 67.12¡Á10(-9) M and 3.50¡Á10(7) M(-1), respectively) than the adults (median 167.4¡Á10(-9) M and 0.84¡Á10(7) M(-1), respectively). These results are consistent with those from the reference method RBA (Standard Deviation score median 9.49 for childhood-onset group and 5.04 for adult-onset group) where the binding can be directly related to the intrinsic affinity of the antibody, suggesting that there is a different etiopathogenic pathway between both types of clinical presentation of the disease. This technology has shown to be a useful tool for the characterization of PAAs parameters as an alternative to radioimmunoassay, with high versatility and reproducibility associated to low occupational and environmental risk. However, this technology is not eligible for routine marker screening, but this is a powerful technique for a fine description of the thermodynamic parameters of antigen-antibody interaction.  ","palabras_clave":"PROINSULIN|AUTOANTIBODIES|CONCENTRATION|AFFINITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88331,"idioma_id":4,"titulo":"Synthesis and structural characterization of Co-doped lanthanum strontium titanates","resumen":"Lanthanum strontium titanates based oxides, materials with perovskite-type crystal structure, are good candidates for symmetrical fuel cell electrodes. They can become good mixed conductors (electronic and ionic) and reach adequate electrocatalytic activity for both oxygen reduction and fuel oxidation reactions if the right doping or structural modification of the (La,Sr)TiO3 compound is performed. However, the crystallographic information reported in the literature indicates a noticeable lack of reproducibility, since it is strongly dependent on synthesis conditions. In this work, La0.4Sr0.6Ti1&#8722;yCoyO3+&#948; (0.0 &#8804; y &#8804; 0.5) synthesis by a low-temperature chemical route and its structural characterization by X-ray powder diffraction and transmission electron microscopy are reported. From Rietveld refinements results, charge compensation mechanisms are studied and their correlation with synthesis parameters is discussed. We show that the creation of Sr vacancies at the A-site of the perovskite-type structure is the main compensation mechanism and their concentration decreases with the incorporation of Co in the crystal structure.","palabras_clave":"SYMMETRICAL FUEL CELL ELECTRODES|La0.4Sr0.6Ti1&#8722;yCoyO3+&#948;|CRYSTAL STRUCTURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88332,"idioma_id":4,"titulo":"Accumulation of aluminium and physiological status of tree foliage in the vicinity of a large aluminium smelter","resumen":"A pollution gradient was observed in tree foliage sampled in the vicinity of a large aluminium production facility in Patagonia (Argentina). Leaves of Eucalyptus rostrata, and Populus hybridus and different needle ages of Pinus spec. were collected and concentrations of aluminium (Al) and sulphur (S) as well as physiological parameters (chlorophyll and lipid oxidation products) were analyzed. Al and S concentrations indicate a steep pollution gradient in the study showing a relationship with the physiological parameters in particular membrane lipid oxidation products. The present study confirms that aluminium smelting results in high Al and sulphur deposition in the study area, and therefore further studies should be carried out taking into account potentially adverse effects of these compounds on human and ecosystem health.","palabras_clave":"Air pollution |Aluminium|Biomontoring|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88333,"idioma_id":4,"titulo":"Accumulation of polycyclic aromatic hydrocarbons and heavy metals in the tree foliage of Eucalyptus rostrata, Pinus radiata and Populus hybridus in the vicinity of a large aluminium smelter in Argentina","resumen":"A pollution gradient of polycyclic aromatic hydrocarbons (PAHs) was observed in tree foliage sampled in the vicinity of a large aluminium production facility in Patagonia (Argentina). Leaves of Eucalyptus rostrata, Populus hybridus and one-year-old needles of Pinus radiata were collected, and concentrations of 12 PAHs including the so-called EPA priority pollutants as well as heavy metals (Cd, Cu, Fe, Mn, Ni and Zn)were analysed. The PAH concentrations indicated a steep pollution gradient in the study area associated with the Al-industry, while the heavy metal content was unrelated to this activity. The present studyconfirms that aluminium smelting results in the deposition of PAH in the study area, and therefore further studies should be carried out taking into account the potentially adverse effects of these compounds on human and ecosystem health.","palabras_clave":"Persistent toxic pollutants|PAH deposition|Atmosphere-vegetation|Biomonitoring"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88334,"idioma_id":4,"titulo":"Virulence factors of the Mycobacterium tuberculosis complex","resumen":"The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes\/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world","palabras_clave":"Mycobacterium tuberculosis|virulence factors|virulence genes|pathogenes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88335,"idioma_id":4,"titulo":"Preserved fertility in a patient with a 46,XY disorder of sex development due to  a new heterozygous mutation in the NR5A1\/SF-1 gene: evidence of 46,XY and 46,XX gonadal dysgenesis phenotype variability in multiple members of an affected kindred.","resumen":"In humans, steroidogenic factor 1 (NR5A1\/SF-1) mutations have been reported tocause gonadal dysgenesis, with or without adrenal failure, in both 46,XY and46,XX individuals. We have previously reported extreme within-family variability in affected 46,XY patients. Even though low ovarian reserve with preservedfertility has been reported in females harboring NR5A1 gene mutations, fertility has only been observed in one reported case in affected 46,XY individuals. Akindred with multiple affected members presenting gonadal dysgenesis was studied.Four 46,XY individuals presented severe hypospadias at birth, one of themassociated with micropenis and cryptorchidism. The other 3 developed spontaneous male puberty, and 1 has fathered 5 children. Four 46,XX patients presentedpremature ovarian failure (one of them was not available for the study) or highfollicle-stimulating hormone levels. Mutational analysis of the NR5A1 generevealed a novel heterozygous mutation, c.938G?¨A, predicted to cause ap.Arg313Hys amino acid change. A highly conserved amino acid of theligand-binding domain of the mature protein is affected, predicting abnormalprotein function. We confirm that preserved fertility can be observed in patientswith a 46,XY disorder of sex development due to heterozygous mutations in theNR5A1 gene.","palabras_clave":"SF-1\/NR5A1 mutations|Disorders of sex development|Male fertility"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88336,"idioma_id":4,"titulo":"Atmospheric corrosion of painted galvanized and 55%Al-Zn steel sheets: results of 12 years of exposure","resumen":"Zinc or 55%Al-Zn alloy-coated steel sheets, either bare or covered by different painting systems, have been exposed for 12 years to the action of the urban atmosphere at the CIDEPINT station located in La Plata (34&#9702; 50_ South, 57&#9702; 53_,West), province of Buenos Aires, Argentina. The samples exposed surface was evaluated through periodical visual inspections, standardized adhesion tests, and electrochemical impedance measurements. The ambient variables monitored were average annual rains and temperatures, time of wetness, sulphur and chloride concentration, relative humidity, and speed and direction of the winds. It was found that in this atmosphere, the corrosion resistance of the bare 55% Al-Zn\/steel sheets was higher than of the galvanized steel, and the polyurethane painting system was more protective than the alkyd and epoxy ones, which degraded after 6-7 years of exposure. ","palabras_clave":"coatings|paint|galvanized steel|cincalum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88337,"idioma_id":4,"titulo":"HSV-1 amplicon vectors launch the production of heterologous rotavirus-like particles and induce rotavirus-specific immune responses in mice","resumen":"Virus-like particles (VLPs) are promising vaccine candidates  because they represent viral antigens in the authentic  conformation of the virion and are therefore readily recognized  by the immune system. As VLPs do not contain  genetic material they are safer than attenuated virus vaccines.  In this study, herpes simplex virus type 1 (HSV-1)  amplicon vectors were constructed to coexpress the  rotavirus (RV) structural genes VP2, VP6, and VP7 and  were used as platforms to launch the production of RVlike  particles (RVLPs) in vector-infected mammalian cells.  Despite the observed splicing of VP6 RNA, full-length  VP6 protein and RVLPs were efficiently produced. Intramuscular  injection of mice with the amplicon vectors as  a two-dose regimen without adjuvants resulted in RVspecific  humoral immune responses and, most importantly,  immunized mice were partially protected at the  mucosal level from challenge with live wild-type (wt)  RV. This work provides proof of principle for the application  of HSV-1 amplicon vectors that mediate the efficient  production of heterologous VLPs as genetic vaccines","palabras_clave":"HSV-1 amplicon vectors|rotavirus|VLPs|immune response"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88338,"idioma_id":4,"titulo":"Dry season diet composition of Eligmodontia moreni (Rodentia, Cricetidae, Sigmodontinae) in a hyper-arid region of the Monte desert (Mendoza, Argentina)","resumen":"We report the diet of Eligmodontia moreni during a dry season in a hyper-arid region of the Monte desert. Most eaten items were plant leaves, arthropods and seeds. Besides the high consumption of leaves, it should be considered as omnivorous with tendency to herbivory due to the high variability in consumption. The high consumption of arthropods was not recorded for other species of the genus. E. moreni shows a high flexibility in the diet, and this may be advantageous in these unpredictable environments.","palabras_clave":"DESERT RODENT|MICROHISTOLOGICAL TECHNIQUE|ONMIVORY|TELTECA RESERVE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88339,"idioma_id":4,"titulo":"Students familiarity and initial contact with species in the Monte desert (Mendoza, Argentina)","resumen":"This study investigates how familiarity and initial contact with species can be explained by social-demographic variables in an arid environment of Argentina. Our main objectives were to investigate which species children are familiar with, and analyse the effect of place of residence, sex and age on students\u2019 knowledge and initial contact with species. In total, 1746 students between 7 and 18 years old participated in the study, from 25 urban and 19 rural schools. Students were asked to write down ten animals and ten plants, and to indicate where they had seen them for the first time. Children were able to name an important number of species but they were mostly acquainted with exotic ones. Familiarity  with species and the use of different sources of information can be explained by interactions between the studied factors, while place of residence was not as significant as we expected. Sex was an important   explanatory variable, likely influenced by differences in roles and children activities\u2019 preferences. It is Necessary to improve the knowledge on native species, particularly those with conservation problems by using information sources close to nature, without neglecting the knowledge of the exotic species that Children showed more familiarity from everyday life.","palabras_clave":"AGE|BIODIVERSITY|KNOWLEDGE|RURAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88340,"idioma_id":4,"titulo":"Forage enrichment with copper and zinc in beef grazing Systems in Argentina","resumen":"The presence of trace elements in water and soils, their absorption by plants, and their transfer to the food chain, is a phenomenon that has been studied in different regions around the world. In Argentina, few studies exist regarding trace element content in soils, and the studies on forages are furthermore scarce. The interest to quantify the levels of trace elements in cattle forage lies in the intrinsic connection between the quality of forage and the nutritional (i.e. Cu and Zn) aspects of cattle health and products for human consumption. Feed lots use feed, which incorporates core minerals whose basic components are Fe, Se, I, Mn, Co, Cu, and Zn. The excess of these trace elements are eliminated through the feces into the environment, therefore, the use of manure from these systems, as a source of organic fertilizer, could reduce environmental contamination, and supplement soils, in areas which are naturally deficient in these micronutrients, for forage growthintended for livestock consumption. Soils from different areas in Argentina were characterized, mainly for their Cu and Zn content. Soil?plant transfer of these trace elements to natural forage was analyzed for agricultural soils with higher content of micronutrients. On the other hand, pot experiments were performed for the enrichment of the forage species, Lolium perenne (ryegrass), with Cu and Zn through fertilization with bovine feces spiked with known concentrations of these trace elements. Soils from copper&#8208;deficient areas used for livestock breeding were used in these experiments. Differences in Cu and Zn concentrations were observed between the fertilized and non-fertilized reactors, while there were no differences found in the Cu and Zn concentrations considering the method of fertilization (homogenization or superficial). These results show that manure from feed lots may be used for forage enrichment with micronutrients.","palabras_clave":"cattle grazing systems|copper|zinc|forage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88341,"idioma_id":4,"titulo":"Modularity of the Consani-Scholten Quintic","resumen":"We prove that the Consani-Scholten quintic, a Calabi-Yau threefold over Q, is Hilbert modular. For this, we refine several techniques known from the context of modular forms. Most notably, we extend the Faltings-Serre-Livn &#769;&nbsp;e method to induced four-dimensional Galois representations over Q. We also need a Sturm bound for Hilbert modular forms; this is developed in an appendix by Jose Burgos Gil and the second author.","palabras_clave":"Consani-Scholten quintic|Hilbert modular form|Sturm bound"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88342,"idioma_id":4,"titulo":"Neural stem cells in the diabetic brain","resumen":"Experimental diabetes in rodents rapidly affects the neurogenic niches of the adult brain. Moreover, behavioral disorders suggest that a similar dysfunction of the neurogenic niches most likely affects diabetic and prediabetic patients. Here, we review our present knowledge about adult neural stem cells, the methods used for their study in diabetic models, and the effects of experimental diabetes. Variations in diet and even a short hyperglycemia profoundly change the structure and the proliferative dynamics of the neurogenic niches. Moreover, alterations of diabetic neurogenic niches appear to be associated with diabetic cognitive disorders. Available evidence supports the hypothesis that, in the adult, early changes of the neurogenic niches might enhance development of the diabetic disease.","palabras_clave":"DIABETES|NEURAL STEM CELLS|SUBVENTRICULAR ZONE|NEUROGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88343,"idioma_id":5,"titulo":"Líquidos iónicos: una alternativa eficaz para la extracción y preconcentración de elementos traza","resumen":"Los líquidos iónicos (ILs, del inglés \u201CIonic Liquids\u201D) se consideran solventes más amigables con el ambiente que los solventes orgánicos convencionales. Presentan características únicas, por ejemplo baja presión de vapor, bajo punto de fusión y elevado poder solvente. También se consideran fases de extracción altamente eficientes para mejorar la selectividad por distintos analitos, convirtiéndolos en herramientas importantes para el análisis elemental. En este trabajo se da una visión global sobre los ILs y el estado del arte en cuanto a su aplicación en química analítica, particularmente en la determinación de metales. Se discuten técnicas modernas basadas en microextracción líquido-líquido (LLME) empleando ILs, incluyendo, microextracción dispersiva líquido-líquido (DLLME), microextracción en gota única (SDME), LLME en línea, etc. Se describen parámetros fundamentales y consideraciones prácticas en la optimización de las metodologías. Se evalúan las distintas estrategias experimentales y los posibles mecanismos implicados en la extracción de metales con ILs. Por último, se mencionan los desarrollos futuros y potenciales campos de aplicación de los ILs para la determinación de metales.","palabras_clave":"LIQUIDOS IONICOS|METALES|EXTRACCION|PRECONCENTRACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88344,"idioma_id":4,"titulo":"Recent advances on the post-translational modifications of EXTs and their roles in plant cell walls","resumen":"The genetic set up and the enzymes that define the O-glycosylation sites and transfer the activated sugars to cell wall glycoprotein Extensins (EXTs) have remained unknown for a long time. We are now beginning to see the emerging components of the molecular machinery that assembles these complex O-glycoproteins on the plant cell wall. Genes conferring the posttranslational modifications, i.e., proline hydroxylation and subsequent O-glycosylation, of the EXTs have been recently identified. In this review we summarize the enzymes that define the O-glycosylation sites on the O-glycoproteins, i.e., the prolyl 4-hydroxylases (P4Hs), the glycosyltransferases that transfer arabinose units (named arabinosyltransferases, AraTs), and the one responsible for transferring a single galactose (galactosyltransferase, GalT) on the protein EXT backbones. We discuss the effects of posttranslational modifications on the structure and function of extensins in plant cell walls.","palabras_clave":"O-glycosylation|cell wall proteins|prolyl-4-hydroxilases"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88345,"idioma_id":4,"titulo":"Laser-induced effects on the electronic features of graphene nanoribbons","resumen":"We study the interplay between lateral confinement and photon-induced   processes on the electronic properties of illuminated graphene   nanoribbons. We find that by tuning the device setup (edges geometries,   ribbon width, and polarization direction), a laser with frequency &#937; may either not affect the electronic structure, or induce bandgaps or depletions at ±&#8463;&#937;\/2,   and\/or at other energies not commensurate with half the photon energy.   Similar features are also observed in the dc conductance, suggesting the   use of the polarization direction to switch on and off the graphene   device. Our results could guide the design of novel types of   optoelectronic nano-devices.","palabras_clave":"GRAPHENE|QUANTUM|TRANSPORT|LASER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88346,"idioma_id":4,"titulo":"Performance of the ATLAS Trigger System in 2010","resumen":"Proton-proton collisions at sqrt{s} = 7 TeV and heavy ion collisions at sqrt{s_NN} = 2.76 TeV were produced by the LHC and recorded using the ATLAS experiment's trigger system in 2010. The LHC is designed with a maximum bunch crossing rate of 40 MHz and the ATLAS trigger system is designed to record approximately 200 of these per second. The trigger system selects events by rapidly identifying signatures of muon, electron, photon, tau lepton, jet, and B meson candidates, as well as using global event signatures, such as missing transverse energy. An overview of the ATLAS trigger system, the evolution of the system during 2010 and the performance of the trigger system components and selections based on the 2010 collision data are shown. A brief outline of plans for the trigger system in 2011 is presented","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88347,"idioma_id":4,"titulo":"Search for anomalous production of prompt like-sign muon pairs and constraints on physics beyond the Standard Model with the ATLAS detector","resumen":"An inclusive search for anomalous production of two prompt, isolated muons with the same electric charge is presented. The search is performed in a data sample corresponding to 1.6 fb^-1 of integrated luminosity collected in 2011 at sqrt(s) = 7 TeV with the ATLAS detector at the LHC. Muon pairs are selected by requiring two isolated muons of the same electric charge with pT &gt; 20 GeV and abs(eta) &lt; 2.5. Minimal requirements are placed on the rest of the event activity. The distribution of the invariant mass of the muon pair m(mumu) is found to agree well with the background expectation. Upper limits on the cross section for anomalous production of two muons with the same electric charge are placed as a function of m(mumu) within a fiducial region defined by the event selection. The fiducial cross- section limit constrains the like-sign top-quark pair-production cross section to be below 3.7 pb at 95% confidence level. The data are also analyzed to search for a narrow like-sign dimuon resonance as predicted for e.g. doubly charged Higgs bosons (H++\/H--). Assuming pair production of H++\/H-- bosons and a branching ratio to muons of 100% (33%), this analysis excludes masses below 355 (244) GeV and 251 (209) GeV for H++\/H-- bosons coupling to left-handed and right-handed fermions, respectively.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88348,"idioma_id":4,"titulo":"Study of jets produced in association with a W boson in pp collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":"We report a study of final states containing a W boson and hadronic jets, produced in proton-proton collisions at a center-of-mass energy of 7 TeV. The data were collected with the ATLAS detector at the CERN LHC and comprise the full 2010 data sample of 36 pb^-1. Cross sections are determined using both the electron and muon decay modes of the W boson and are presented as a function of inclusive jet multiplicity, N_jet, for up to five jets. At each multiplicity, cross sections are presented as a function of jet transverse momentum, the scalar sum of the transverse momenta of the charged lepton, missing transverse momentum, and all jets, the invariant mass spectra of jets, and the rapidity distributions of various combinations of leptons and final-state jets. The results, corrected for all detector effects and for all backgrounds such as diboson and top quark pair production, are compared with particle-level predictions from perturbative QCD. Leading-order multiparton event generators, normalized to the NNLO total cross section for inclusive W-boson production, describe the data reasonably well for all measured inclusive jet multiplicities. Next-to-leading-order calculations from MCFM, studied here for N_jet &gt;= 2, and BlackHat-Sherpa, studied here for N_jet &gt;= 4, are found to be mostly in good agreement with the data.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88349,"idioma_id":4,"titulo":"Measurement of the top quark pair production cross-section with ATLAS in the single lepton channel","resumen":": A measurement of the production cross-section for top quark pairs (t tbar) in pp collisions at sqrt{s} = 7 TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in the single lepton topology by requiring an electron or muon, large missing transverse momentum and at least three jets. With a data sample of 35\/pb, two different multivariate methods, one of which uses b-quark jet identification while the other does not, use kinematic variables to obtain cross-section measurements of sigma (t tbar) = 187 +\/- 11 (stat.) +18-17 (syst.) +\/- 6 (lumi.) pb and sigma (t tbar) = 173 +\/- 17 (stat.) +18-16 (syst.) +\/- 6 (lumi.) pb} respectively. The two measurements are in agreement with each other and with QCD calculations. The first measurement has a better a priori sensitivity and constitutes the main result of this Letter.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88350,"idioma_id":4,"titulo":"Rapidity gap cross sections measured with the ATLAS detector in pp collisions at &#8730; s =7 TeV","resumen":"Pseudorapidity gap distributions in proton-proton collisions at &#8730;s=7 ~TeV are studied using a minimum bias data sample with an integrated luminosity of 7.1 &#956;b&#8722;1. Cross sections are measured differentially in terms of &#916;&#951; F , the larger of the pseudorapidity regions extending to the limits of the ATLAS sensitivity, at &#951;=±4.9, in which no final state particles are produced above a transverse momentum threshold pcutT . The measurements span the region 0<&#916;&#951; F <8 for 200~MeV<pcutT<800~MeV . At small &#916;&#951; F , the data test the reliability of hadronisation models in describing rapidity and transverse momentum fluctuations in final state particle production. The measurements at larger gap sizes are dominated by contributions from the single diffractive dissociation process (pp&#8594;Xp), enhanced by double dissociation (pp&#8594;XY) where the invariant mass of the lighter of the two dissociation systems satisfies M Y &#8818;7 GeV. The resulting cross section is d&#963;\/d&#916;&#951; F &#8776;1 mb for &#916;&#951; F &#8819;3. The large rapidity gap data are used to constrain the value of the Pomeron intercept appropriate to triple Regge models of soft diffraction. The cross section integrated over all gap sizes is compared with other LHC inelastic cross section measurements.","palabras_clave":"hadron collisions|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88351,"idioma_id":4,"titulo":"Search for decays of stopped, long-lived particles from 7 TeV pp collisions with the ATLAS detector","resumen":"New metastable massive particles with electric and colour charge are features of many theories beyond the Standard Model. A search is performed for long-lived gluino-based R-hadrons with the ATLAS detector at the LHC using a data sample corresponding to an integrated luminosity of 31 pb&#8722;1. We search for evidence of particles that have come to rest in the ATLAS detector and decay at some later time during the periods in the LHC bunch structure without proton\u2013proton collisions. No significant deviations from the expected backgrounds are observed, and a cross-section limit is set. It can be interpreted as excluding gluino-based R-hadrons with masses less than 341 GeV at the 95 % C.L., for lifetimes from 10&#8722;5 to 103 seconds and a neutralino mass of 100 GeV.","palabras_clave":"Long lived particles|R-hadrons|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88352,"idioma_id":4,"titulo":"Search for pair production of a heavy up-type quark decaying to a W boson and a b quark in the lepton+jets channel with the ATLAS detector","resumen":"A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming subsequent decay to a W boson and a b quark, t't'bar -&gt; W+b W-bbar. The search is based on 1.04 fb^-1 of proton-proton collisions at sqrt(s) = 7 TeV collected by the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton+jets final state, characterized by a high transverse momentum isolated electron or muon, high missing transverse momentum and at least three jets. No significant excess of events above the background expectation is observed. A 95% C.L. lower limit is set at m(t') &gt; 404 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88353,"idioma_id":4,"titulo":"Search for anomaly-mediated supersymmetry breaking with the ATLAS detector based on a disappearing-track signature in pp collisions at &#8730;s = 7 TeV","resumen":" In models of anomaly-mediated supersymmetry breaking (AMSB), the lightest chargino is predicted to have a lifetime long enough to be detected in collider experiments. This letter explores AMSB scenarios in pp collisions at sqrt(s) = 7 TeV by attempting to identify decaying charginos which result in tracks that appear to have few associated hits in the outer region of the tracking system. The search was based on data corresponding to an integrated luminosity of 1.02 fb^-1 collected with the ATLAS detector in 2011. The pT spectrum of candidate tracks is found to be consistent with the expectation from Standard Model background processes and constraints on the lifetime and the production cross section were obtained. In the minimal AMSB framework with m_3\/2 &lt; 32 TeV, m_0 &lt; 1.5 TeV, tan(beta) = 5 and mu &gt; 0, a chargino having mass below 92 GeV and a lifetime between 0.5 ns and 2 ns is excluded at 95% confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88354,"idioma_id":4,"titulo":"Search for down-type fourth generation quarks with the ATLAS detector in events with one lepton and hadronically decaying W bosons","resumen":"This Letter presents a search for pair production of heavy down-type quarks decaying via b'-&gt;Wt in the lepton + jets channel, as b'b'-&gt;WtWt-&gt;bbWWWW-&gt;lvbbqqqqqq. In addition to requiring exactly one lepton, large missing transverse momentum and at least six jets, the invariant mass of nearby jet pairs is used to identify high transverse momentum W bosons. In data corresponding to an integrated luminosity of 1.04 fb^-1 from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector, a heavy down-type quark with mass less than 480 GeV is excluded at the 95% confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88355,"idioma_id":4,"titulo":"Measurement of the azimuthal ordering of charged hadrons with the ATLAS detector","resumen":"This paper presents a measurement of the ordering of charged hadrons in the azimuthal angle relative to the beam axis in high-energy proton-proton collisions at the Large Hadron Collider (LHC). A spectral analysis of correlations between longitudinal and transverse components of the momentum of the charged hadrons, driven by the search for phenomena related to the structure of the QCD field, is performed. Data were recorded with the ATLAS detector at centre-of-mass energies of sqrt(s) = 900 GeV and sqrt(s) = 7 TeV. The correlations measured in a phase space region dominated by low-pT particles are not well described by conventional models of hadron production. The measured spectra show features consistent with the fragmentation of a QCD string represented by a helix-like ordered gluon chain.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88356,"idioma_id":4,"titulo":"Search for FCNC single top-quark production at &#8730;s =7 TeV with the ATLAS detector","resumen":"The results of a search for an excited bottom-quark b&#8270;b&#8270; in pp collisions at s=7 TeV, using 4.7&nbsp; fb&#8722;14.7&nbsp; fb&#8722;1 of data collected by the ATLAS detector at the LHC are presented. In the model studied, a single b&#8270;b&#8270;-quark is produced through a chromomagnetic interaction and subsequently decays to a W   boson and a top quark. The search is performed in the dilepton and   lepton&nbsp;+&nbsp;jets final states, which are combined to set limits on b&#8270;b&#8270;-quark couplings for a range of b&#8270;b&#8270;-quark masses. For a benchmark with unit size chromomagnetic and Standard Model-like electroweak b&#8270;b&#8270; couplings, b&#8270;b&#8270; quarks with masses less than 870 GeV870 GeV are excluded at the 95% credibility level.","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88357,"idioma_id":4,"titulo":"Search for new particles decaying to ZZ using final states with leptons and jets with the ATLAS detector in &#8730; s = 7 TeV proton\u2013proton collisions","resumen":"A search is presented for a narrow resonance decaying to a pair of Z bosons using data corresponding to 1.02\/fb of integrated luminosity collected by the ATLAS experiment from pp collisions at sqrt(s) = 7 TeV. Events containing either four charged leptons (llll) or two charged leptons and two jets (lljj) are analyzed and found to be consistent with the Standard Model background expectation. Lower limits on a resonance mass are set using the Randall-Sundrum (RS1) graviton model as a benchmark. Using both llll and lljj events, an RS1 graviton with k\/m_pl = 0.1 and mass between 325 and 845 GeV is excluded at 95% confidence level. In addition, the llll events are used to set a fiducial cross section limit of sigma_fiducial(pp -&gt; X -&gt; ZZ &lt; 0.92 pb at 95% confidence level for any new sources of ZZ production with m_ZZ greater than 300 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88358,"idioma_id":4,"titulo":"Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC","resumen":"The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88359,"idioma_id":4,"titulo":"Measurement of the production cross section of an isolated photon associated with jets in proton-proton collisions at &#8730;s = 7 TeV with the ATLAS detector'","resumen":"A measurement of the cross section for the production of an isolated photon in association with jets in proton-proton collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. Photons are reconstructed in the pseudorapidity range |eta(gamma)|&lt;1.37 and with a transverse energy E_T(gamma)&gt;25 GeV. Jets are reconstructed in the rapidity range |y(jet)|&lt;4.4 and with a transverse momentum p_T(jet)&gt;20 GeV. The differential cross section dsigma\/dE_T(gamma) is measured, as a function of the photon transverse energy, for three different rapidity ranges of the leading-p_T jet: |y(jet)|&lt;1.2, 1.2&lt;=|y(jet)|&lt;2.8 and 2.8&lt;=|y(jet)|&lt; 4.4. For each rapidity configuration the same-sign (eta(gamma)y(jet)&gt;=0) and opposite-sign (eta(gamma)y(jet)&lt;0) cases are studied separately. The results are based on an integrated luminosity of 37 pb^-1, collected with the ATLAS detector at the LHC. Next-to-leading order perturbative QCD calculations are found to be in fair agreement with the data, except for E_T(gamma)&lt;~45 GeV, where the theoretical predictions overestimate the measured cross sections.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88360,"idioma_id":4,"titulo":"Search for second generation scalar leptoquarks in pp collisions at &#8730; s = 7 TeV with the ATLAS detector","resumen":"The results of a search for the production of second generation scalar leptoquarks are presented for final states consisting of either two muons and at least two jets or a muon plus missing transverse momentum and at least two jets. A total of 1.03 fb&#8722;1 integrated luminosity of proton-proton collision data produced by the Large Hadron Collider at s&#8730;=7 TeV and recorded by the ATLAS detector is used for the search. The event yields in the signal regions are found to be consistent with the Standard Model background expectations. The production of second generation leptoquarks is excluded for a leptoquark mass m LQ<594 (685) GeV at 95 % confidence level, for a branching ratio of 0.5 (1.0) for leptoquark decay to a muon and a quark.","palabras_clave":"Leptoquarks|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88361,"idioma_id":4,"titulo":"Determination of the strange quark density of the proton from ATLAS measurements of the W&#8722;>l&#957; and Z&#8722;>ll cross sections","resumen":"A QCD analysis is reported of ATLAS data on inclusive W± and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x&#8764;0.01. Specifically, the data support the hypothesis of a symmetric composition of the light quark sea at low x. The ratio of the strange-to-down sea quark distributions is determined to be 1.00-0.28+0.25 at absolute four-momentum transfer squared Q2=1.9&#8201;&#8201;GeV2 and x=0.023.","palabras_clave":"Strange-quark|W boson|Z boson|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88362,"idioma_id":4,"titulo":"Observation of spin correlation in tt&#713; events from pp collisions at sqrt(s) = 7 TeV using the ATLAS detector","resumen":"A measurement of spin correlation in ttbar production is reported using data collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 2.1 fb^-1. Candidate events are selected in the dilepton topology with large missing transverse energy and at least two jets. The difference in azimuthal angle between the two charged leptons in the laboratory frame is used to extract the correlation between the top and antitop quark spins. In the helicity basis the measured degree of correlation corresponds to 0.40 +0.09 -0.08, in agreement with the next-to-leading-order Standard Model prediction. The hypothesis of zero spin correlation is excluded at 5.1 standard deviations.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88363,"idioma_id":4,"titulo":"Measurement of the charge asymmetry in top quark pair production in pp collisions at &#8730; s = 7 TeV using the ATLAS detector","resumen":"A measurement of the top-antitop production charge asymmetry A_C is presented using data corresponding to an integrated luminosity of 1.04 fb^-1 of pp collisions at sqrt(s) = 7 TeV collected by the ATLAS detector at the LHC. Events are selected with a single lepton (electron or muon), missing transverse momentum and at least four jets of which at least one jet is identified as coming from a b-quark. A kinematic fit is used to reconstruct the ttbar event topology. After background subtraction, a Bayesian unfolding procedure is performed to correct for acceptance and detector effects. The measured value of A_C is A_C = -0.018 +\/- 0.028 (stat.) +\/- 0.023 (syst.), consistent with the prediction from the MC@NLO Monte Carlo generator of A_C = 0.006 +\/- 0.002. Measurements of A_C in two ranges of invariant mass of the top-antitop pair is also shown.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88364,"idioma_id":4,"titulo":"Search for heavy neutrinos and right-handed W bosons in events with two leptons and jets in pp collisions at &#8730; s =7 TeV with the ATLAS detector","resumen":" This letter reports on a search for hypothetical heavy neutrinos, N, and right-handed gauge bosons, WR, in events with two high transverse momentum leptons and at least one high transverse momentum hadronic jet. The results were obtained from data corresponding to an integrated luminosity of 2.1 fb^-1 collected in proton-proton collisions at sqrt(s) = 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. No excess above the Standard Model background expectation is observed. Excluded mass regions for Majorana and Dirac neutrinos are presented using two approaches for interactions that violate lepton and lepton-flavour numbers. One approach uses an effective operator framework, the other approach is guided by the Left-Right Symmetric Model. The results described in this letter represent the most stringent limits to date on the masses of heavy neutrinos and WR bosons obtained in direct searches.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88365,"idioma_id":4,"titulo":"Search for events with large missing transverse momentum, jets, and at least two tau leptons in 7 TeV proton-proton collision data with the ATLAS detector","resumen":" A search for events with large missing transverse momentum, jets, and at least two tau leptons has been performed using 2 fb^-1 of proton-proton collision data at sqrt(s) = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed and a 95% CL visible cross section upper limit for new phenomena is set. A 95% CL lower limit of 32 TeV is set on the GMSB breaking scale Lambda independent of tan(beta). These limits provide the most stringent tests to date in a large part of the considered parameter space.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88366,"idioma_id":4,"titulo":"Search for the decay Bs0 -> mu mu with the ATLAS detector","resumen":"blind analysis searching for the decay Bs0 -&gt; mumu has been performed using proton-proton collisions at a centre-of-mass energy of 7 TeV recorded with the ATLAS detector at the LHC. With an integrated luminosity of 2.4 fb^(-1) no excess of events over the background expectation is found and an upper limit is set on the branching fraction BR(Bs0 -&gt; mu mu) &lt; 2.2 (1.9) x10^(-8) at 95% (90%) confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88367,"idioma_id":4,"titulo":"Search for pair production of a new quark that decays to a Z boson and a bottom quark with the ATLAS detector","resumen":"A search is reported for the pair production of a new quark, b', with at least one b' decaying to a Z boson and a bottom quark. The data, corresponding to 2.0 fb^-1 of integrated luminosity, were collected from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector at the CERN Large Hadron Collider. Using events with a b-tagged jet and a Z boson reconstructed from opposite-charge electrons, the mass distribution of large transverse momentum b' candidates is tested for an enhancement. No evidence for a b' signal is detected in the observed mass distribution, resulting in the exclusion at 95% confidence level of b' quarks with masses m_{b'} &lt; 400 GeV that decay entirely via b' to Z+b. In the case of a vector-like singlet b' mixing solely with the third Standard Model generation, masses m_{b'} &lt; 358 GeV are excluded.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88368,"idioma_id":4,"titulo":"Search for supersymmetry with jets, missing transverse momentum and at least one hadronically decaying &#964; lepton in proton-proton collisions at &#8730;s=7 TeV with the ATLAS detector","resumen":"A search for production of supersymmetric particles in &#64257;nal states containing jets, missing transversemomentum, and at least one hadronically decaying &#964; lepton is presented. The data were recorded bythe ATLAS experiment in &#8730;s = 7 TeV proton\u2013proton collisions at the Large Hadron Collider. No excessabove the Standard Model background expectation was observed in 2.05 fb&#8722;1 of data. The results areinterpreted in the context of gauge mediated supersymmetry breaking models with Mmess = 250 TeV,N5= 3, &#956; > 0, and Cgrav = 1. The production of supersymmetric particles is excluded at 95% C.L. up toa supersymmetry breaking scale &#923;=30 TeV, independent of tan&#946;, and up to &#923;=43 TeV for large tan&#946;","palabras_clave":"SUSY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88369,"idioma_id":4,"titulo":"Search for TeV-scale gravity signatures in final states with leptons and jets with the ATLAS detector at &#8730; s = 7 TeV","resumen":"The production of events with multiple high transverse momentum particles including charged leptons and jets is measured, using 1.04 fb-1 of proton-proton collision data recorded by the ATLAS detector during the first half of 2011 at sqrt(s) = 7 TeV. No excess beyond Standard Model expectations is observed, and upper limits on the fiducial cross sections for non-Standard Model production of these final states are set. Using models for string ball and black hole production and decay, exclusion contours are determined as a function of mass threshold and the fundamental gravity scale.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88370,"idioma_id":4,"titulo":"Search for supersymmetry in events with three leptons and missing transverse momentum in &#8730;s = 7 TeV pp collisions with the ATLAS detector","resumen":"A search for the weak production of charginos and neutralinos into final states with three electrons or muons and missing transverse momentum is presented. The analysis uses 2.06 fb^-1 of sqrt(s) = 7 TeV proton-proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with standard model expectations in two signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric and simplified models. For the simplified models, degenerate lightest chargino and next-to-lightest neutralino masses up to 300 GeV are excluded for mass differences from the lightest neutralino up to 300 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88371,"idioma_id":4,"titulo":"Measurement of &#964; polarization in W&#8722;>&#964;&#957; decays with the ATLAS detector in pp collisions at sqrt(s) = 7 TeV","resumen":"In this paper, a measurement of &#964; polarization in W&#8594;&#964;&#957; decays is presented. It is measured from the energies of the decay products in hadronic &#964; decays with a single final state charged particle. The data, corresponding to an integrated luminosity of 24 pb&#8722;1, were collected by the ATLAS experiment at the Large Hadron Collider in 2010. The measured value of the &#964; polarization is P&#964;=&#8722;1.06±0.04 (stat)+0.05&#8722;0.07 (syst) , in agreement with the Standard Model prediction, and is consistent with a physically allowed 95 % CL interval [&#8722;1,&#8722;0.91]. Measurements of &#964; polarization have not previously been made at hadron colliders.","palabras_clave":"Tau |polarization|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88372,"idioma_id":4,"titulo":"Search for Scalar Top Quark Pair Production in Natural Gauge Mediated Supersymmetry Models with the ATLAS Detector in pp Collisions at &#8730;s =7 TeV","resumen":"The results of a search for pair production of the lighter scalar partners of top quarks in 2.05 fb-1 of pp collisions at sqrt(s) =7 TeV using the ATLAS experiment at the LHC are reported. Scalar top quarks are searched for in events with two same flavour opposite-sign leptons (electrons or muons) with invariant mass consistent with the Z boson mass, large missing transverse momentum and jets in the final state. At least one of the jets is identified as originating from a b-quark. No excess over Standard Model expectations is found. The results are interpreted in the framework of R-parity conserving, gauge mediated Supersymmetry breaking `natural' scenarios, where the neutralino is the next-to-lightest supersymmetric particle. Scalar top quark masses up to 310 GeV are excluded for the lightest neutralino mass between 115 GeV and 230 GeV at 95% confidence level, reaching an exclusion of the scalar top quark mass of 330 GeV for the lightest neutralino mass of 190 GeV. Scalar top quark masses below 240 GeV are excluded for all values of the lightest neutralino mass above the Z boson mass.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88373,"idioma_id":4,"titulo":"Search for a fermiophobic Higgs boson in the diphoton decay channel with the ATLAS detector","resumen":"A search for a fermiophobic Higgs boson using diphoton events produced in proton-proton collisions at a centre-of-mass energy of                                                                 s&#8730;=7&nbsp;TeV                               is performed using data corresponding to an integrated luminosity of 4.9&nbsp;fb&#8722;1 collected by the ATLAS experiment at the Large Hadron Collider. A specific benchmark model is considered where all the fermion couplings to the Higgs boson are set to zero and the bosonic couplings are kept at the Standard Model values (fermiophobic Higgs model). The largest excess with respect to the background-only hypothesis is found at 125.5&nbsp;GeV, with a local significance of 2.9 standard deviations, which reduces to 1.6 standard deviations when taking into account the look-elsewhere effect. The data exclude the fermiophobic Higgs model in the ranges 110.0\u2013118.0&nbsp;GeV and 119.5\u2013121.0&nbsp;GeV at 95&nbsp;% confidence level.","palabras_clave":"Higgs|Fermiophofic|ATLAS|Search"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88374,"idioma_id":4,"titulo":"Search for Lepton Flavour Violation in the emu Continuum with the ATLAS detector in &#8730;s = 7 TeV pp collisions at the LHC","resumen":"This paper presents a search for the t-channel exchange of an R-parity violating scalar top quark (\\={t}) in the emu continuum using 2.1\/fb of data collected by the ATLAS detector in sqrt(s) = 7 TeV pp collisions at the Large Hadron Collider. Data are found to be consistent with the expectation from the Standard Model backgrounds. Limits on R-parity-violating couplings at 95% C.L. are calculated as a function of the scalar top mass (m_{\\={t}}). The upper limits on the production cross section for pp-&gt;emuX, through the t-channel exchange of a scalar top quark, ranges from 170 fb for m_{\\={t}}=95 GeV to 30 fb for m_{\\={t}}=1000 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88375,"idioma_id":4,"titulo":"Search for tb resonances in proton-proton collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":"This Letter presents a search for tb resonances in 1.04\/fb of LHC proton-proton collision data collected by the ATLAS detector at a center-of-mass energy of 7 TeV. Events with a lepton, missing transverse momentum, and two jets are selected and the invariant mass of the corresponding final state is reconstructed. The search exploits the shape of the tb invariant mass distribution compared to the expected Standard Model backgrounds. The model of a right-handed W'_R with Standard Model-like couplings is chosen as the benchmark model for this search. No statistically significant excess of events is observed in data, and upper limits on the cross section times the branching ratio of W'_R resonances at 95% CL lie in the range 6.1-1.0 pb for W'_R masses ranging from 0.5 to 2.0 TeV. These limits are translated into a lower bound on the allowed right-handed W'_R mass, giving m_{W'_R} &gt; 1.13 TeV at 95% CL.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88376,"idioma_id":4,"titulo":"Measurement of the t-channel single top-quark production cross section in pp collisions at &#8730; s = 7 TeV with the ATLAS detector","resumen":"We report a measurement of the cross section of single top-quark production in the t-channel using 1.04 fb^-1 of pp collision data at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC. Selected events feature one electron or muon, missing transverse momentum, and two or three jets, exactly one of them identified as originating from a b quark. The cross section is measured by fitting the distribution of a multivariate discriminant constructed with a neural network, yielding sigma(t)= 83 +\/- 4 (stat.) +20 -19 (syst) pb which is in good agreement with the prediction of the Standard Model. Using the ratio of the measured to the theoretically predicted cross section and assuming that the top-quark-related CKM matrix elements obey the relation |V(tb)| &gt;&gt; |V(ts)|, |V(td)|, the coupling strength at the W-t-b vertex is determined to be |V(tb)| = 1.13 +0.14 -0.13. If it is assumed that |V(tb)| &lt;= 1 a lower limit of |V(tb)|&gt;0.75 is obtained at the 95% confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88377,"idioma_id":4,"titulo":"A search for tt&#713; resonances with the ATLAS detector in 2.05 fb^{-1} of proton&#8722;proton collisions at sqrt{s}=7 TeV","resumen":"A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integrated luminosity of 2.05 fb&#8722;1, which was recorded in 2011 at a proton-proton centre-of-mass energy of 7 TeV. No evidence for a resonance is found and limits are set on the production cross-section times branching ratio to tt&#713; for narrow and wide resonances. For narrow Z&#8242; bosons, the observed 95 % Bayesian credibility level limits range from 9.3 pb to 0.95 pb for masses in the range of m Z&#8242;=500 GeV to m Z&#8242;=1300 GeV. The corresponding excluded mass region for a leptophobic topcolour Z&#8242; boson (Kaluza-Klein gluon excitation in the Randall-Sundrum model) is m Z&#8242;<880 GeV ( mgKK<1130 GeV ).","palabras_clave":"Top quark pair|ATLAS|Z' boson"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88378,"idioma_id":4,"titulo":"Evidence for the associated production of a W boson and a top quark in ATLAS at &#8730;s = 7 TeV","resumen":"This letter presents evidence for the associated production of a W boson and a top quark using 2.05 fb^-1 of pp collision data at sqrt(s) = 7 TeV accumulated with the ATLAS detector at the LHC. The analysis is based on the selection of the dileptonic final states with events featuring two isolated leptons, electron or muon, with significant transverse missing momentum and at least one jet. An approach based on boosted decision trees has been developed to improve the discrimination of single top-quark Wt events from background. A template fit to the final classifier distributions is performed to determine the cross-section. The result is incompatible with the background-only hypothesis at the 3.3 sigma level, the expected sensitivity assuming the Standard Model production rate being 3.4 sigma. The corresponding cross-section is determined and found to be sigma_Wt = 16.8 +\/- 2.9 (stat) +\/- 4.9 (syst) pb, in good agreement with the Standard Model expectation. From this result the CKM matrix element |V_{tb}| = 1.03{+0.16}{-0.19} is derived assuming that the Wt production through |V_{ts}| and |V_{td}| is small.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88379,"idioma_id":4,"titulo":"Search for a Standard Model Higgs boson in the H -> ZZ -> l+l&#8722;&#957;&#957;&#713; decay channel using 4.7 fb&#8722;1 of sqrt(s) = 7 TeV data with the ATLAS detector","resumen":"A search for a Standard Model Higgs boson decaying via H &#8594;ZZ&#8594;l+l&#8722;&#957;&#957;¯, where  represents electrons or muons, is presented. It is based on proton\u2013proton collision data at &#8730;s=7 TeV, collected by the ATLAS experiment at the LHC during 2011 and corresponding to an integrated luminosity of 4.7 fb&#8722;1. The data agree with the expected Standard Model backgrounds. Upper limits on the Higgs boson production cross section are derived for Higgs boson masses between 200 GeV and 600 GeV and the production of a Standard Model Higgs boson with a mass in the range 319\u2013558 GeV is excluded at the 95% con&#64257;dence level.","palabras_clave":"Higgs boson|SM |ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88380,"idioma_id":4,"titulo":"Measurement of event shapes at large momentum transfer with the ATLAS detector in pp collisions at &#8730; s =7 TeV","resumen":"A measurement of event shape variables is presented for large momentum transfer proton-proton collisions using the ATLAS detector at the Large Hadron Collider. Six event shape variables calculated using hadronic jets are studied in inclusive multi-jet events in 35 pb^-1 of integrated luminosity at a center-of-mass energy of sqrt(s) = 7 TeV. These measurements are compared to predictions by three Monte Carlo event generators containing leading-logarithmic parton showers matched to leading order matrix elements for 2 to 2 and 2 to n (n=2,...6) scattering. Measurements of the third-jet resolution parameter, aplanarity, thrust, sphericity, and transverse sphericity are generally well described. The mean value of each event shape variable is evaluated as a function of the average momentum of the two leading jets pT1 and pT2, with a mean pT approaching 1 TeV.","palabras_clave":"ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88381,"idioma_id":4,"titulo":"Search for a standard model Higgs boson in the mass range 200 - 600-GeV in the H&#8594;ZZ&#8594;&#8467;+&#8467;&#8722;qq&#713; decay channel with the ATLAS detector","resumen":"A search for a heavy Standard Model Higgs boson decaying via H&#8594;ZZ&#8594;&#8467;+&#8467;&#8722;qq¯, where &#8467;=e&#8467;=e or &#956;, is presented. The search uses a data set of pp collisions at s=7&nbsp;TeV, corresponding to an integrated luminosity of 4.7&nbsp;fb&#8722;14.7&nbsp;fb&#8722;1   collected in 2011 by the ATLAS detector at the CERN LHC. No significant   excess of events above the estimated background is found. Upper limits   at 95% confidence level on the production cross section of a Higgs boson   with a mass in the range between 200 and 600&nbsp;GeV600&nbsp;GeV are derived. A Standard Model Higgs boson with a mass in the range 300&nbsp;GeV&#10877;mH&#10877;322&nbsp;GeV300&nbsp;GeV&#10877;mH&#10877;322&nbsp;GeV or 353&nbsp;GeV&#10877;mH&#10877;410&nbsp;GeV353&nbsp;GeV&#10877;mH&#10877;410&nbsp;GeV is excluded at 95% CL. The corresponding expected exclusion range is 351&nbsp;GeV&#10877;mH&#10877;404&nbsp;GeV351&nbsp;GeV&#10877;mH&#10877;404&nbsp;GeV at 95% CL.","palabras_clave":"HIGGS|SEARCH|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88382,"idioma_id":4,"titulo":"Measurement of the b-hadron production cross section using decays to D&#8727;&#956;&#8722;X final states in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector","resumen":"The b-hadron production cross section is measured with the ATLAS detector in pp collisions at sqrt(s) = 7 TeV, using 3.3 pb^-1 of integrated luminosity, collected during the 2010 LHC run. The b-hadrons are selected by partially reconstructing D*muX final states. Differential cross sections are measured as functions of the transverse momentum and pseudorapidity. The measured production cross section for a b-hadron with pT&gt;9 GeV and |eta|&lt;2.5 is 32.7 pm 0.8 (stat) ^{+4.5}_{-6.8} (syst) ub, higher than the next-to-leading-order QCD predictions but consistent within the experimental and theoretical uncertainties.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88383,"idioma_id":4,"titulo":"ATLAS measurements of the properties of jets for boosted particle searches","resumen":"Measurements are presented of the properties of high transverse momentum jets, produced in proton-proton collisions at a center-of-mass energy of &#8730;s=7&#8201;&#8201;TeV. The data correspond to an integrated luminosity of 35&#8201;&#8201;pb-1 and were collected with the ATLAS detector in 2010. Jet mass, width, eccentricity, planar flow and angularity are measured for jets reconstructed using the anti-kt algorithm with distance parameters R=0.6 and 1.0, with transverse momentum pT>300&#8201;&#8201;GeV and pseudorapidity |&#951;|<2. The measurements are compared to the expectations of Monte Carlo generators that match leading-logarithmic parton showers to leading-order, or next-to-leading-order, matrix elements. The generators describe the general features of the jets, although discrepancies are observed in some distributions.","palabras_clave":"Jets|Boosted jets|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88384,"idioma_id":4,"titulo":"Search for the Higgs boson in the H&#8594;WW&#8594; lnujj decay channel at &#8730;s=7 TeV with the ATLAS detector","resumen":"A search for the Standard Model Higgs boson has been performed in the H&#8594;WW&#8594;&#8467;&#957;jjH&#8594;WW&#8594;&#8467;&#957;jj channel using 4.7 fb&#8722;1 of pp collision data recorded at a centre-of-mass energy of s=7 TeV with the ATLAS detector at the Large Hadron Collider. Higgs boson candidates produced in association with zero, one or two jets are included in the analysis to maximize the acceptance for both gluon fusion and weak boson fusion Higgs boson production processes. No significant excess of events is observed over the expected background and limits on the Higgs boson production cross section are derived for a Higgs boson mass in the range 300 GeV&lt;mH&lt;600 GeV300 GeV&lt;mH&lt;600 GeV. The best sensitivity is reached for mH=400 GeVmH=400 GeV, where the observed (expected) 95% confidence level upper bound on the cross section for H&#8594;WWH&#8594;WW produced in association with zero or one jet is 2.2 pb (1.9 pb), corresponding to 1.9 (1.6) times the Standard Model prediction. In the Higgs boson plus two jets channel, which is more sensitive to the weak boson fusion process, the observed (expected) 95% confidence level upper bound on the cross section for H&#8594;WWH&#8594;WW production with mH=400 GeVmH=400 GeV is 0.7 pb (0.6 pb), corresponding to 7.9 (6.5) times the Standard Model prediction.","palabras_clave":"Higgs|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88385,"idioma_id":4,"titulo":"Search for the Standard Model Higgs boson produced in association with a vector boson and decaying to a b-quark pair with the ATLAS detector","resumen":"This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110&#10877;mH&#10877;130&nbsp;GeV110&#10877;mH&#10877;130&nbsp;GeV produced in association with a W or Z boson and decaying to bb¯. Three decay channels are considered: ZH&#8594;&#8467;+&#8467;&#8722;bb¯, WH&#8594;&#8467;&#957;bb¯ and ZH&#8594;&#957;&#957;¯bb¯, where &#8467; corresponds to an electron or a muon. No evidence for Higgs boson production is observed in a dataset of 7&nbsp;TeV7&nbsp;TeVpp collisions corresponding to 4.7&nbsp;fb&#8722;14.7&nbsp;fb&#8722;1 of integrated luminosity collected by ATLAS in 2011. Exclusion limits on Higgs boson production, at the 95%95% confidence level, of 2.5 to 5.5 times the Standard Model cross section are obtained in the mass range 110\u2013130&nbsp;GeV110\u2013130&nbsp;GeV. The expected exclusion limits range between 2.5 and 4.9 for the same mass interval.","palabras_clave":"ATLAS|HEP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88386,"idioma_id":4,"titulo":"Measurement of the &#923;b lifetime and mass in the ATLAS experiment","resumen":"A measurement of the &#923;b0 lifetime and mass in the decay channel &#923;b0&#8594;J\/&#968;(&#956;+&#956;-)&#923;0(p&#960;-) is presented. The analysis uses a signal sample of about 2200 &#923;b0 and &#923;&#773; b0 decays that are reconstructed in 4.9&#8201;&#8201;fb-1 of ATLAS pp collision data collected in 2011 at the LHC center-of-mass energy of 7 TeV. A simultaneous mass and decay time maximum likelihood fit is used to extract the &#923;b0 lifetime and mass. They are measured to be &#964;&#923;b=1.449±0.036(stat)±0.017(syst)&#8201;&#8201;ps and m&#923;b=5619.7±0.7(stat)±1.1(syst)&#8201;&#8201;MeV.","palabras_clave":"&#923;b0 baryon|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88387,"idioma_id":4,"titulo":"Search for top and bottom squarks from gluino pair production in final states with missing transverse energy and at least three b-jets with the ATLAS detector","resumen":"This letter reports the results of a search for top and bottom squarks from gluino pair production in 4.7 fb&#8722;1 of pp collisions at s&#8730;=7 TeV using the ATLAS detector at the LHC. The search is performed in events with large missing transverse momentum and at least three jets identified as originating from a b-quark. Exclusion limits are presented for a variety of gluino-mediated models with gluino masses up to 1 TeV excluded.","palabras_clave":"SUSY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88388,"idioma_id":5,"titulo":"Vagas impresiones de supuesta felicidad","resumen":"Esta breve reseña de la exposición 'Bye bye American Pie' (Museo de Arte Latinoamericano de Buenos Aires, 2012) se focaliza en los aspectos temáticos que conforman las obras de la muestra, pensados desde una perspectiva freudiana. Así, la vía psicoanalítica (central en el discurso curatorial de esta exhibición) permite dar cuenta de ciertas críticas de los artistas involucrados a las formas de vida y de consumo de la sociedad estadounidense, y el modo en que ellas se ven anudadas por el relato formulado por la curaduría.","palabras_clave":"EXPOSICIÓN|MALBA|CONSUMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88389,"idioma_id":4,"titulo":"Measurement of charged-particle event shape variables in s&#8730;=7 TeV proton-proton interactions with the ATLAS detector","resumen":"The measurement of several event shape variables is presented in minimum bias pp collisions at a center-of-mass energy of 7 TeV using the ATLAS detector at the LHC. The observables studied are the transverse thrust, thrust minor and transverse sphericity, each defined using the momenta perpendicular to the beam direction of the final state charged particles. Events with at least six charged particles are selected. In addition to the differential distributions, the evolution of each event shape variable as a function of the leading charged particle transverse momentum, charged particle multiplicity and summed transverse momentum is presented. Predictions from several Monte Carlo models have been compared with data and they show significant deviations from data.","palabras_clave":"Event shapes|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88390,"idioma_id":4,"titulo":"Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC","resumen":"A search for the Standard Model Higgs boson in proton\u2013proton collisions with the ATLAS detector atthe LHC is presented. The datasets used correspond to integrated luminosities of approximately 4.8 fb&#8722;1collected at &#8730;s=7 TeV in 2011 and 5.8 fb&#8722;1 at &#8730;s=8 TeV in 2012. Individual searches in the channelsH &#8594; Z Z(&#8727;)&#8594;4, H &#8594;&#947; &#947; and H &#8594;W W(&#8727;)&#8594;e&#957;&#956;&#957; in the 8 TeV data are combined with previouslypublished results of searches for H &#8594; Z Z(&#8727;), W W(&#8727;), b¯b and &#964;+&#964;&#8722; in the 7 TeV data and results fromimproved analyses of the H &#8594; Z Z(&#8727;)&#8594;4 and H &#8594;&#947; &#947; channels in the 7 TeV data. Clear evidence forthe production of a neutral boson with a measured mass of 126.0±0.4 (stat)±0.4 (sys) GeV is presented.This observation, which has a signi&#64257;cance of 5.9 standard deviations, corresponding to a background&#64258;uctuation probability of 1.7×10&#8722;9, is compatible with the production and decay of the Standard ModelHiggs boson.","palabras_clave":"Higgs boson|SM |ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88391,"idioma_id":4,"titulo":"Measurement of W ± Z production in proton-proton collisions at &#8730; s = 7 TeV with the ATLAS detector","resumen":"A study of WZ production in proton-proton collisions at   sqrt(s) = 7 TeV is presented using data corresponding to an integrated   luminosity of 4.6 fb^-1 collected with the ATLAS detector at the Large   Hadron Collider in 2011. In total, 317 candidates, with a background   expectation of 68+\/-10 events, are observed in double-leptonic decay   final states with electrons, muons and missing transverse momentum. The   total cross-section is determined to be sigma_WZ(tot) =   19.0+1.4\/-1.3(stat.)+\/-0.9(syst.)+\/-0.4(lumi.) pb, consistent with the   Standard Model expectation of 17.6+1.1\/-1.0 pb. Limits on anomalous   triple gauge boson couplings are derived using the transverse momentum   spectrum of Z bosons in the selected events. The cross section is also   presented as a function of Z boson transverse momentum and diboson   invariant mass.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88392,"idioma_id":5,"titulo":"Guerras figuradas (y no tanto)","resumen":"En esta reseña de 'Claridad, la vanguardia en lucha' (Museo Nacional de Bellas Artes, 2012) se analizan las características retóricas y temáticas presentadas por el dispositivo de exhibición y, más generalmente, el relato curatorial.De esta manera se otorga importancia a los modos de selección de obra y de lenguajes artísticos presentes en la exposición, además de a ciertas características de los paratextos y otros elementos paracuratoriales. Además se fijará la atención en el vínculo de esta muestra temporaria con algunas piezas de la colección permanente, como un modo de actualización y puesta en circulación de ciertos valores simbólicos.","palabras_clave":"CLARIDAD|EXPOSICIÓN|GUERRA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88393,"idioma_id":4,"titulo":"Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at &#8730;s = 7 TeV with the ATLAS detector","resumen":"A search for direct pair production of supersymmetric top squarks (stop_1) is presented, assuming the stop_1 decays into a top quark and the lightest supersymmetric particle, neutralino_1, and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted Standard Model background of 13.5+3.7-3.6 (4.4+1.7-1.3) events in two signal regions based on int(Ldt) = 4.7 fb^-1 of pp collision data taken at sqrt(s) = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the stop_1 versus neutralino_1 mass plane is evaluated: 370&lt;m(stop_1)&lt;465 GeV is excluded for m(neutralino_1)~0 GeV while m(stop_1)=445 GeV is excluded for m(neutralino_1)&lt;=50 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88394,"idioma_id":5,"titulo":"Un mundo a-Duchampiano","resumen":"Este breve artículo intenta abordar la importancia de Marcel Duchamp en la historia del arte, y algunos de los efectos que sus propuestas rupturistas producen en la actualidad. En este sentido, por un lado se da cuenta de las posibilidades conceptuales habilitadas por el francés en el campo de las artes (desde las neo-vanguardias hasta muchas producciones contemporáneas) y, por otro lado, de los fenómenos de estetización de la cotidianidad que caracterizan la mayoría de los fenómenos sociales desde la posmodernidad.","palabras_clave":"DUCHAMP|VANGUARDIAS|ESTETIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88395,"idioma_id":4,"titulo":"Search for direct slepton and gaugino production in final states with two leptons and missing transverse momentum with the ATLAS detector in pp collisions at &#8730; s = 7 TeV","resumen":"A search for the electroweak pair production of charged   sleptons and weak gauginos decaying into final states with two leptons   is performed using 4.7 fb-1 of proton-proton collision data at sqrt(s)=7   TeV recorded with the ATLAS experiment at the Large Hadron Collider. No   significant excesses are observed with respect to the prediction from   Standard Model processes. In the scenario of direct slepton production,   if the sleptons decay directly into the lightest neutralino, left-handed   slepton masses between 85 and 195 GeV are excluded at 95% confidence   level for a 20 GeV neutralino. Chargino masses between 110 and 340 GeV   are excluded in the scenario of direct production of wino-like chargino   pairs decaying into the lightest neutralino via an intermediate on-shell   charged slepton for a 10 GeV neutralino. The results are also   interpreted in the framework of the phenomenological minimal   supersymmetric Standard Model.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88396,"idioma_id":4,"titulo":"Search for light scalar top quark pair production in final states with two leptons with the ATLAS detector in &#8730;s = 7 TeV proton-proton collisions","resumen":" A search is presented for the pair production of light scalar top quarks in sqrt(s) = 7 TeV proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider. This analysis uses the full data sample collected during 2011 that corresponds to a total integrated luminosity of 4.7 fb-1. Light scalar top quarks are searched for in events with two opposite-sign leptons (e, mu), large missing transverse momentum and at least one jet in the final state. No excess over Standard Model expectations is found, and the results are interpreted under the assumption that the light scalar top decays to a b-quark in addition to an on-shell chargino whose decay occurs through a virtual W boson. If the chargino mass is 106 GeV, light scalar top quark masses up to 130 GeV are excluded for neutralino masses below 70 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88397,"idioma_id":4,"titulo":"Search for diphoton events with large missing transverse momentum in 7 TeV proton-proton collision data with the ATLAS detector","resumen":"A search for diphoton events with large missing transverse momentum has been performed using proton\u2013proton collision data at &#8730;s = 7 TeV recorded with the ATLAS detector, corresponding to an integratedluminosity of 4.8 fb&#8722;1. No excess of events was observed above the Standard Model prediction andmodel-dependent 95% con&#64257;dence level exclusion limits are set. In the context of a generalised modelof gauge-mediated supersymmetry breaking with a bino-like lightest neutralino of mass above 50 GeV,gluinos (squarks) below 1.07 TeV (0.87 TeV) are excluded, while a breaking scale &#923; below 196 TeV isexcluded for a minimal model of gauge-mediated supersymmetry breaking. For a speci&#64257;c model withone universal extra dimension, compacti&#64257;cation scales 1\/R <1.40 TeV are excluded. These limits providethe most stringent tests of these models to date.","palabras_clave":"SUSY|Extra dimensions|ATLAS|Diphoton"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88398,"idioma_id":4,"titulo":"ATLAS search for a heavy gauge boson decaying to a charged lepton and a neutrino in pp collisions at &#8730; s =7 TeV","resumen":"The ATLAS detector at the LHC is used to search for high-mass states,   such as heavy charged gauge bosons (W´), decaying to a charged lepton   (electron or muon) and a neutrino. Results are presented based on the   analysis of pp collisions at a centre-of-mass energy of 7 TeV   corresponding to an integrated luminosity of 4.7 fb-1. No excess beyond   Standard Model expectations is observed. A W´ with Sequential Standard   Model couplings is excluded at the 95% credibility level for masses up   to 2.55 TeV. Excited chiral bosons (W*) with equivalent coupling   strength are excluded for masses up to 2.42 TeV.","palabras_clave":"ATLAS|CERN|HEP|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88399,"idioma_id":4,"titulo":"Search for Supersymmetry in Events with Large Missing Transverse Momentum, Jets, and at Least One Tau Lepton in 7 TeV Proton-Proton Collision Data with the ATLAS Detector","resumen":"A search for supersymmetry (SUSY) in events with large missing transverse momentum, jets, and at leastone hadronically decaying &#964; lepton, with zero or one additional light lepton (e\/&#956;), has been performed using 4.7 fb&#8722;1 of proton-proton collision data at &#8730; s = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed and a 95 % confidence level visible cross-section upper limit for new phenomena is set. In the framework of gauge-mediated SUSY-breaking models, lower limits on the mass scale &#923; are set at 54 TeV in the regions where the ˜ &#964;1 is the next-to-lightest SUSY particle (tan&#946; > 20). These limits provide the most stringent tests to date of GMSB models in a large part of the parameter space considered.","palabras_clave":"SUSY|GMSB|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88400,"idioma_id":4,"titulo":"Measurement of W+\\W&#8722; production in pp collisions at s&#8730;=7 TeV with the ATLAS detector and limits on anomalous WWZ and WW&#947; couplings","resumen":"This paper presents a measurement of the W^+W^- production cross section in pp collisions at sqrt{s}=7 TeV. The leptonic decay channels are analyzed using data corresponding to an integrated 4.6 fb-1 collected with the ATLAS detector at the Large Hadron Collider. The W^+W^- production cross section sigma(pp -> W^+W^-+X) is measured to be 51.9 +- 2.0 (stat) +- 3.9 (syst) +- 2.0 (lumi) pb, compatible with the Standard Model prediction of 44.7 +2.1 -1.9 pb. A measurement of the normalized fiducial cross section as a function of the leading lepton transverse momentum is also presented. The reconstructed transverse momentum distribution of the leading lepton is used to extract limits on anomalous WWZ and WWgamma couplings.","palabras_clave":"W boson|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88401,"idioma_id":10,"titulo":"Search for pair production of massive particles decaying into three quarks with the ATLAS detector in &#8730;s =7 TeV pp collisions at the LHC","resumen":"A search is conducted for hadronic three-body decays of a new massive coloured particle in sqrt(s) = 7 TeV pp collisions at the LHC using an integrated luminosity of 4.6\/fb collected by the ATLAS detector. Supersymmetric gluino pair production in the context of a model with R-parity violation is used as a benchmark scenario. The analysis is divided into two search channels, each optimised separately for their sensitivity to high-mass and low-mass gluino production. The first search channel uses a stringent selection on the transverse momentum of the six leading jets and is performed as a counting experiment. The second search channel focuses on low-mass gluinos produced with a large boost. Large-radius jets are selected and the invariant mass of each of the two leading jets is used as a discriminant between the signal and the background. The results are found to be consistent with Standard Model expectations and limits are set on the allowed gluino mass.","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88402,"idioma_id":4,"titulo":"Search for doubly charged Higgs bosons in like-sign dilepton final states at &#8730; s = 7 TeV with the ATLAS detector","resumen":"A search for doubly charged Higgs bosons decaying to pairs of electrons   and\/or muons is presented. The search is performed using a data sample   corresponding to an integrated luminosity of 4.7 fb&#8722;1 of pp collisions at                                                                     s&#8730;                                 = 7 TeV collected by the ATLAS detector at the LHC. Pairs of prompt, isolated, high-p                                T leptons with the same electric charge (e                                ±                                e                                ±, e                                ±                                &#956;                                ±, &#956;                                ±                                &#956;                                ±) are   selected, and their invariant mass distribution is searched for a narrow   resonance. No significant excess over Standard Model background   expectations is observed, and limits are placed on the cross section   times branching ratio for pair production of doubly charged Higgs   bosons. The masses of doubly charged Higgs bosons are constrained   depending on the branching ratio into these leptonic final states.   Assuming pair production, coupling to left-handed fermions, and a   branching ratio of 100&#8201;% for each final state, masses below 409&nbsp;GeV,   375&nbsp;GeV, and 398&nbsp;GeV are excluded for e                                ±                                e                                ±, e                                ±                                &#956;                                ±, and &#956;                                ±                                &#956;                                ±, respectively","palabras_clave":"ATLAS|High |energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88403,"idioma_id":4,"titulo":"Search for long-lived, heavy particles in final states with a muon and multi-track displaced vertex in proton-proton collisions at &#8730;s=7 TeV with the ATLAS detector","resumen":"Many extensions of the Standard Model posit the existence of heavy particles with long lifetimes. In thisLetter, results are presented of a search for events containing one or more such particles, which decayat a signi&#64257;cant distance from their production point, using a &#64257;nal state containing charged hadronsand an associated muon. This analysis uses a data sample of proton\u2013proton collisions at &#8730;s = 7 TeVcorresponding to an integrated luminosity of 4.4 fb&#8722;1 collected in 2011 by the ATLAS detector operatingat the Large Hadron Collider. Results are interpreted in the context of R-parity violating supersymmetricscenarios. No events in the signal region are observed and limits are set on the production cross sectionfor pair production of supersymmetric particles, multiplied by the square of the branching fraction for aneutralino to decay to charged hadrons and a muon, based on the scenario where both of the producedsupersymmetric particles give rise to neutralinos that decay in this way. However, since the searchstrategy is based on triggering on and reconstructing the decay products of individual long-lived particles,irrespective of the rest of the event, these limits can easily be reinterpreted in scenarios with differentnumbers of long-lived particles per event. The limits are presented as a function of neutralino lifetime,and for a range of squark and neutralino masses","palabras_clave":"Long-Lived particles|ATLAS|RPV|SUSY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88404,"idioma_id":4,"titulo":"Measurement of ZZ production in pp collisions at s&#8730;=7 TeV and limits on anomalous ZZZ and ZZ&#947; couplings with the ATLAS detector","resumen":"A measurement of the ZZ production cross section in proton-proton collisions at &#8730;s=7 TeV using data recorded by the ATLAS experiment at the Large Hadron Collider is presented. In a data sample corresponding to an integrated luminosity of 4.6 fb&#8722;1 collected in 2011, events are selected that are consistent either with two Z bosons decaying to electrons or muons or with one Z boson decaying to electrons or muons and a second Z boson decaying to neutrinos. The ZZ (*) &#8594; &#8467; + &#8467; &#8722; &#8467; &#8242;+ &#8467; &#8242;&#8722; and ZZ&#8594;&#8467;+&#8467;&#8722;&#957;&#957;&#8722; cross sections are measured in restricted phase-space regions. These results are then used to derive the total cross section for ZZ events produced with both Z bosons in the mass range 66 to 116 GeV, &#963;totZZ=6.7±0.7(stat.)+0.4&#8722;0.3(syst.)±0.3(lumi.) pb, which is consistent with the Standard Model prediction of 5.89+0.22&#8722;0.18 pb calculated at next-to-leading order in QCD. The normalized differential cross sections in bins of various kinematic variables are presented. Finally, the differential event yield as a function of the transverse momentum of the leading Z boson is used to set limits on anomalous neutral triple gauge boson couplings in ZZ production.","palabras_clave":"ZZ production|Anomalous couplings|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88405,"idioma_id":4,"titulo":"Measurement of Upsilon production in 7 TeV pp collisions at ATLAS","resumen":"Using 1.8 fb-1 of pp collisions at a center-of-mass energy of 7 TeV recorded by the ATLAS detector at the Large Hadron Collider, we present measurements of the production cross sections of Upsilon(1S,2S,3S) mesons. Upsilon mesons are reconstructed using the di-muon decay mode. Total production cross sections for p_T&lt;70 GeV and in the rapidity interval |Upsilon|&lt;2.25 are measured to be 8.01+-0.02+-0.36+-0.31 nb, 2.05+-0.01+-0.12+-0.08 nb, 0.92+-0.01+-0.07+-0.04 nb respectively, with uncertainties separated into statistical, systematic, and luminosity measurement effects. In addition, differential cross section times di-muon branching fractions for Upsilon(1S), Upsilon(2S), and Upsilon(3S) as a function of Upsilon transverse momentum p_T and rapidity are presented. These cross sections are obtained assuming unpolarized production. If the production polarization is fully transverse or longitudinal with no azimuthal dependence in the helicity frame the cross section may vary by approximately +-20%. If a non-trivial azimuthal dependence is considered, integrated cross sections may be significantly enhanced by a factor of two or more. We compare our results to several theoretical models of Upsilon meson production, finding that none provide an accurate description of our data over the full range of Upsilon transverse momenta accessible with this dataset.","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88406,"idioma_id":4,"titulo":"Observation of Associated Near-side and Away-side Long-range Correlations in sNN&#8722;&#8722;&#8722;&#8722;&#8730;=5.02 TeV Proton-lead Collisions with the ATLAS Detector","resumen":"Two-particle correlations in relative azimuthal angle (&#916;&#981;) and pseudorapidity (&#916;&#951;) are measured in &#8730;sNN=5.02&#8201;&#8201;TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1&#8201;&#8201;&#956;b-1 of data as a function of transverse momentum (pT) and the transverse energy (&#931;ETPb) summed over 3.1&lt;&#951;&lt;4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2&lt;|&#916;&#951;|&lt;5) \u201Cnear-side\u201D (&#916;&#981;&#8764;0) correlation that grows rapidly with increasing &#931;ETPb. A long-range \u201Caway-side\u201D (&#916;&#981;&#8764;&#960;) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small &#931;ETPb, is found to match the near-side correlation in magnitude, shape (in &#916;&#951; and &#916;&#981;) and &#931;ETPb dependence. The resultant &#916;&#981; correlation is approximately symmetric about &#960;\/2, and is consistent with a dominant cos&#8289;2&#916;&#981; modulation for all &#931;ETPb ranges and particle pT.","palabras_clave":"ATLAS|high|energy|physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88407,"idioma_id":4,"titulo":"Measurement of the cross section for top-quark pair production in pp collisions at s&#8730;=7 TeV with the ATLAS detector using final states with two high-pt leptons","resumen":"A measurement is reported of the production cross section of top-quark pairs in proton-proton collisions at a center-of-mass energy of 7 TeV recorded with the ATLAS detector at the LHC. Candidate events have a signature consistent with containing two isolated leptons, large missing transverse momentum, and at least two jets. Using a data sample corresponding to an integrated luminosity of 0.70 fb^-1, a t-tbar production cross section sigmattbar=176 +\/-5 (stat) +14 -11 (syst) +\/- 8 (lum.) pb is measured for an assumed top-quark mass of m_t = 172.5 GeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88408,"idioma_id":4,"titulo":"Search for same-sign top quark production and fourth-generation down-type quarks in pp collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":"A search is presented for same-sign top-quark production and down-type heavy quarks of charge -1\/3 in events with two isolated leptons (electrons or muons) that have the same electric charge, at least two jets and large missing transverse momentum. The data are selected from pp collisions at sqrt(s)=7 TeV recorded by the ATLAS detector and correspond to an integrated luminosity of 1.04 inverse femtobarns. The observed data are consistent with expectations from Standard Model processes. Upper limits are set at 95% confidence level on the cross section of new sources of same-sign top-quark pair production of 1.4-2.0 pb depending on the assumed mediator mass. Upper limits are also set on the pair-production cross-section for new heavy down-type quarks\/ a lower limit of 450 GeV is set at 95% confidence level on the mass of heavy down-type quarks under the assumption that they decay 100% of the time to Wt.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88409,"idioma_id":4,"titulo":"Forward-backward correlations and charged-particle azimuthal distributions in pp interactions using the ATLAS detector","resumen":"Using inelastic proton-proton interactions at sqrt(s) = 900 GeV and 7 TeV, recorded by the ATLAS detector at the LHC, measurements have been made of the correlations between forward and backward charged-particle multiplicities and, for the first time, between forward and backward charged-particle summed transverse momentum. In addition, jet-like structure in the events is studied by means of azimuthal distributions of charged particles relative to the charged particle with highest transverse momentum in a selected kinematic region of the event. The results are compared with predictions from tunes of the PYTHIA and HERWIG++ Monte Carlo generators, which in most cases are found to provide a reasonable description of the data.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88410,"idioma_id":4,"titulo":"Measurement of inclusive two-particle angular correlations in pp collisions with the ATLAS detector at the LHC","resumen":"We present a measurement of two-particle angular correlations in proton-proton collisions at sqrt(s) = 900 GeV and 7 TeV. The collision events were collected during 2009 and 2010 with the ATLAS detector at the Large Hadron Collider using a single-arm minimum bias trigger. Correlations are measured for charged particles produced in the kinematic range of transverse momentum pT &gt; 100 MeV and pseudorapidity |eta| &lt; 2.5. A complex structure in pseudorapidity and azimuth is observed at both collision energies. Results are compared to Pythia 8 and Herwig++ as well as to the AMBT2B, DW and Perugia 2011 tunes of Pythia 6. The data are not satisfactorily described by any of these models.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88411,"idioma_id":4,"titulo":"Measurement of the W boson polarization in top quark decays with the ATLAS detector","resumen":"This paper presents measurements of the polarization of W bosons in top quark decays, derived from ttbar events with missing transverse momentum, one charged lepton and at least four jets, or two charged leptons and at least two jets. Data from pp collisions at a centre-of-mass energy of 7 TeV were collected with the ATLAS experiment at the LHC and correspond to an integrated luminosity of 1.04 fb^-1. The measured fractions of longitudinally, left- and right-handed polarization are F_0=0.67+\/-0.07, F_L=0.32+\/-0.04 and F_R=0.01+\/-0.05, in agreement with the Standard Model predictions. As the polarization of the W bosons in top quark decays is sensitive to the Wtb vertex Lorentz structure and couplings, the measurements were used to set limits on anomalous contributions to the Wtb couplings.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88412,"idioma_id":4,"titulo":"A search for flavour changing neutral currents in top-quark decays in pp collision data collected with the ATLAS detector at s&#8730;=7 TeV","resumen":"A search for flavour changing neutral current (FCNC) processes in top-quark decays by the ATLAS Collaboration is presented. Data collected from pp collisions at the LHC at a centre-of-mass energy of sqrt(s) = 7 TeV during 2011, corresponding to an integrated luminosity of 2.1 fb^-1, were used. A search was performed for top-quark pair-production events, with one top quark decaying through the t-&gt;Zq FCNC (q=u,c) channel, and the other through the Standard Model dominant mode t-&gt;Wb. Only the decays of the Z boson to charged leptons and leptonic W-boson decays were considered as signal. Consequently, the final-state topology is characterised by the presence of three isolated charged leptons, at least two jets and missing transverse momentum from the undetected neutrino. No evidence for an FCNC signal was found. An upper limit on the t-&gt;Zq branching ratio of BR(t-&gt;Zq)&lt;0.73% is set at the 95% confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88413,"idioma_id":4,"titulo":"Hunt for new phenomena using large jet multiplicities and missing transverse momentum with ATLAS in 4.7 fb^-1 of sqrt(s) = 7 TeV proton-proton collisions.","resumen":"Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb&#8722;1 of pp collision data at s&#8730;=7TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from &#8805;6 to &#8805;9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA\/CMSSM supersymmetric model, where, for large universal scalar mass m 0, gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below","palabras_clave":"New physics|Jets|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88414,"idioma_id":4,"titulo":"Time-dependent angular analysis of the decay Bs -> J\/psi phi and extraction of Delta Gamma_s and the CP-violating weak phase phi_s by ATLAS","resumen":"A measurement of B0s&#8594;J\/&#968;&#981; decay parameters, including the CP -violating weak phase &#981; s and the decay width difference &#916;&#915; s is reported, using 4.9 fb&#8722;1 of integrated luminosity collected in 2011 by the ATLAS detector from LHC pp collisions at a centre-of-mass energy s&#8730;=7 TeV. The mean decay width &#915; s and the transversity amplitudes |A 0(0)|2 and |A &#8741;(0)|2 are also measured. The values reported for these parameters are: &#981;s=0.22±0.41 (stat.)±0.10 (syst.) rad  &#916;&#915;s=0.053±0.021 (stat.)±0.010 (syst.) ps&#8722;1  &#915;s=0.677±0.007 (stat.)±0.004 (syst.) ps&#8722;1  |A0(0)|2=0.528±0.006 (stat.)±0.009 (syst.)  |A&#8741;(0)|2=0.220±0.008 (stat.)±0.007 (syst.)   where the values quoted for &#981; s and &#916;&#915; s correspond to the solution compatible with the external measurements to which the strong phase &#948; &#8869; is constrained and where &#916;&#915;s is constrained to be positive. The fraction of S-wave KK or f 0 contamination through the decays B0s&#8594;J\/&#968;K+K&#8722;(f0) is measured as well and is found to be consistent with zero. Results for &#981; s and &#916;&#915; s are also presented as 68%, 90% and 95% likelihood contours, which show agreement with Standard model expectations.","palabras_clave":"B0s decay|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88415,"idioma_id":4,"titulo":"Measurements of the pseudorapidity dependence of the total transverse energy in proton-proton collisions at &#8730;s = 7 TeV with ATLAS","resumen":"This paper describes   measurements of the sum of the transverse energy of particles as a   function of particle pseudorapidity, eta, in proton-proton collisions at   a centre-of-mass energy, sqrt(s) = 7 TeV using the ATLAS detector at   the Large Hadron Collider. The measurements are performed in the region   |eta| &lt; 4.8 for two event classes: those requiring the presence of   particles with a low transverse momentum and those requiring particles   with a significant transverse momentum. In the second dataset   measurements are made in the region transverse to the hard scatter. The   distributions are compared to the predictions of various Monte Carlo   event generators, which generally tend to underestimate the amount of   transverse energy at high |eta|.  ","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88416,"idioma_id":4,"titulo":"Search for high-mass resonances decaying to dilepton final states in pp collisions at s**(1\/2) = 7 TeV with the ATLAS detector","resumen":"The ATLAS detector at the Large Hadron Collider is used to search for   high-mass resonances decaying to an electron-positron pair or a   muon-antimuon pair. The search is sensitive to heavy neutral Z´ gauge   bosons, Randall-Sundrum gravitons, Z* bosons, techni-mesons,   Kaluza-Klein Z\/gamma bosons, and bosons predicted by Torsion models.   Results are presented based on an analysis of pp collisions at a   center-of-mass energy of 7 TeV corresponding to an integrated luminosity   of 4.9\/fb in the dielectron channel and 5.0\/fb in the dimuon channel. A   Z´ boson with Standard Model-like couplings is excluded at 95 percent   confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton   with coupling k\/Mbar = 0.1 is excluded at 95 percent confidence level   for masses below 2.16 TeV. Limits on the other models are also   presented, including Technicolor and Minimal Z´ Models.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88417,"idioma_id":4,"titulo":"Search for a heavy top-quark partner in final states with two leptons with the ATLAS detector at the LHC","resumen":"The results of a search for direct pair production of heavy top-quark partners in 4.7 fb-1 of integrated luminosity from pp collisions at sqrt(s) = 7 TeV collected by the ATLAS detector at the LHC are reported. Heavy top-quark partners decaying into a top quark and a neutral non-interacting particle are searched for in events with two leptons in the final state. No excess above the Standard Model expectation is observed. Limits are placed on the mass of a supersymmetric scalar top and of a spin-1\/2 top-quark partner. A spin-1\/2 top-quark partner with a mass between 300 GeV and 480 GeV, decaying to a top quark and a neutral non-interacting particle lighter than 100 GeV, is excluded at 95% confidence level.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88418,"idioma_id":4,"titulo":"Search for direct chargino production in anomaly-mediated supersymmetry breaking models based on a disappearing-track signature in pp collisions at s&#8730;=7 TeV with the ATLAS detector","resumen":"A search for direct chargino production in anomaly-mediated supersymmetry breaking scenarios is performed in pp collisions at s&#8730;=7TeV using 4.7 fb&#8722;1 of data collected with the ATLAS experiment at the LHC. In these models, the lightest chargino is predicted to have a lifetime long enough to be detected in the tracking detectors of collider experiments. This analysis explores such models by searching for chargino decays that result in tracks with few associated hits in the outer region of the tracking system. The transverse-momentum spectrum of candidate tracks is found to be consistent with the expectation from the Standard Model background processes and constraints on chargino properties are obtained.","palabras_clave":"Direct chargino|SUSY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88419,"idioma_id":4,"titulo":"Search for dark matter candidates and large extra dimensions in events with a jet and missing transverse momentum with the ATLAS detector","resumen":"A search for new phenomena in events with a high-energy jet and large missing transverse momentum is performed using data from proton-proton collisions at s&#8730;=7 TeV with the ATLAS experiment at the Large Hadron Collider. Four kinematic regions are explored using a dataset corresponding to an integrated luminosity of 4.7 fb&#8722;1. No excess of events beyond expectations from Standard Model processes is observed, and limits are set on large extra dimensions and the pair production of dark matter particles.","palabras_clave":"Dark Matter|Extra dimensions|ATLAS|Monojet"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88420,"idioma_id":4,"titulo":"ANOMALOUS TIME RELAXATION OF THE NONVOLATILE RESISTIVE STATE IN BIPOLAR RESISTIVE-SWITCHING OXIDE-BASED MEMORIES","resumen":"We have studied long time relaxation effects on the nonvolatile resistance state produced by resistive switching  in devices composed by ceramic YBa2Cu3O7&#8722;&#948; and La0.7Sr0.3MnO3\/metal (Au, Pt, Ag) interfaces. The time  relaxation can be described by a stretched exponential law that is characterized by a power exponent (n) close  to 1\/2. We found that the characteristic time (&#964; ) increases with increasing temperature and applied power. The  origin of the relaxation effect can be related to oxygen diffusion processes, which were recently associated with  the mechanism of bipolar switching in complex oxide interfaces. We argue that the anomalous behavior can  be understood in terms of diffusion of oxygen ions (or oxygen vacancies) on a two-dimensional surface with  a temperature-dependent density of trapping centers, which may correspond, physically, to the diffusion along  grain boundaries.","palabras_clave":"Resistive switching|EPIR effect|RRAM|memory effect"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88421,"idioma_id":4,"titulo":"Search for anomaly-mediated supersymmetry breaking with the ATLAS detector based on a disappearing-track signature in $pp$ collisions at $\\sqrt{s}=7$ TeV","resumen":"In models of anomaly-mediated supersymmetry breaking (AMSB), the lightest chargino is predicted to have a lifetime long enough to be detected in collider experiments. This letter explores AMSB scenarios in pp collisions at sqrt(s) = 7 TeV by attempting to identify decaying charginos which result in tracks that appear to have few associated hits in the outer region of the tracking system. The search was based on data corresponding to an integrated luminosity of 1.02 fb^-1 collected with the ATLAS detector in 2011. The pT spectrum of candidate tracks is found to be consistent with the expectation from Standard Model background processes and constraints on the lifetime and the production cross section were obtained. In the minimal AMSB framework with m_3\/2  0, a chargino having mass below 92 GeV and a lifetime between 0.5 ns and 2 ns is excluded at 95% confidence level.","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88422,"idioma_id":4,"titulo":"Determination of the strange quark density of the proton from ATLAS measurements of the $W -> l \\nu$ and $Z -> ll$ cross sections","resumen":"A QCD analysis is reported of ATLAS data on inclusive W and Z boson production in pp collisions at the LHC, jointly with ep deep inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x ~ 0.01. Specifically, the data support the hypothesis of a symmetric composition of the light quark sea at low x. The ratio of the strange-to-down sea quark distributions is determined to be 1.00(+0.25-0.28) at absolute four-momentum transfer squared Q^2 = 1.9 GeV^2 and x = 0.023.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88423,"idioma_id":4,"titulo":"Jet mass and substructure of inclusive jets in $\\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS experiment","resumen":"Recent studies have highlighted the potential of jet substructure techniques to identify the hadronic decays of boosted heavy particles. These studies all rely upon the assumption that the internal substructure of jets generated by QCD radiation is well understood. In this article, this assumption is tested on an inclusive sample of jets recorded with the ATLAS detector in 2010, which corresponds to 35 pb^-1 of pp collisions delivered by the LHC at sqrt(s) = 7 TeV. In a subsample of events with single pp collisions, measurementes corrected for detector efficiency and resolution are presented with full systematic uncertainties. Jet invariant mass, kt splitting scales and n-subjettiness variables are presented for anti-kt R = 1.0 jets and Cambridge-Aachen R = 1.2 jets. Jet invariant-mass spectra for Cambridge-Aachen R = 1.2 jets after a splitting and filtering procedure are also presented. Leading-order parton-shower Monte Carlo predictions for these variables are found to be broadly in agreement with data. The dependence of mean jet mass on additional pp interactions is also explored.","palabras_clave":"atlas|lhc"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88424,"idioma_id":4,"titulo":"Search for gluinos in events with two same-sign leptons, jets and missing transverse momentum with the ATLAS detector in $pp$ collisions at $\\sqrt{s}=7$ TeV","resumen":"A search is presented for gluinos decaying via the supersymmetric partner of the top quark using events with two same-sign leptons, jets and missing transverse momentum. The analysis is performed with 2.05 fb^-1 of integrated luminosity from pp collisions at sqrt(s) = 7 TeV collected by the ATLAS detector at the LHC. No excess beyond the Standard Model expectation is observed and exclusion limits are derived for simplified models where the gluino decays via the supersymmetric partner of the top quark and in the MSUGRA\/CMSSM framework. In those scenarios, gluino masses below 550 GeV are excluded at 95% CL within the parameter space considered, significantly extending the coverage with respect to existing limits. Depending on the model parameters, gluino masses up to 750 GeV can also be excluded at 95% CL.","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88425,"idioma_id":4,"titulo":"Search for supersymmetry in $pp$ collisions at $\\sqrt{s}=7$ TeV in final states with missing transverse momentum and $b^-$ jets with the ATLAS detector","resumen":"The results of a search for supersymmetry in events with large missing transverse momentum and heavy flavour jets using an integrated luminosity corresponding to 2.05 fb^-1 of pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider are reported. No significant excess is observed with respect to the prediction for Standard Model processes. Results are interpreted in a variety of R-parity conserving models in which scalar bottoms and tops are the only scalar quarks to appear in the gluino decay cascade, and in an SO(10) model framework. Gluino masses up to 600-900 GeV are excluded, depending on the model considered.","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88426,"idioma_id":4,"titulo":"Search for supersymmetry in events with three leptons and missing transverse momentum in $\\sqrt{s}=7$ TeV $pp$ collisions with the ATLAS detector","resumen":"A search for the weak production of charginos and neutralinos into final states with three electrons or muons and missing transverse momentum is presented. The analysis uses 2.06 fb^-1 of sqrt(s) = 7 TeV proton-proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with standard model expectations in two signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric and simplified models. For the simplified models, degenerate lightest chargino and next-to-lightest neutralino masses up to 300 GeV are excluded for mass differences from the lightest neutralino up to 300 GeV.","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88427,"idioma_id":4,"titulo":"Search for scalar top quark pair production in natural gauge mediated supersymmetry models with the ATLAS detector in $pp$ collisions at $\\sqrt{s}=7$ TeV","resumen":"The results of a search for pair production of the lighter scalar partners of top quarks in 2.05 fb-1 of pp collisions at sqrt(s) =7 TeV using the ATLAS experiment at the LHC are reported. Scalar top quarks are searched for in events with two same flavour opposite-sign leptons (electrons or muons) with invariant mass consistent with the Z boson mass, large missing transverse momentum and jets in the final state. At least one of the jets is identified as originating from a b-quark. No excess over Standard Model expectations is found. The results are interpreted in the framework of R-parity conserving, gauge mediated Supersymmetry breaking `natural' scenarios, where the neutralino is the next-to-lightest supersymmetric particle. Scalar top quark masses up to 310 GeV are excluded for the lightest neutralino mass between 115 GeV and 230 GeV at 95% confidence level, reaching an exclusion of the scalar top quark mass of 330 GeV for the lightest neutralino mass of 190 GeV. Scalar top quark masses below 240 GeV are excluded for all values of the lightest neutralino mass above the Z boson mass.","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88428,"idioma_id":4,"titulo":"Measurement of the Lambda_b lifetime and mass in the ATLAS experiment","resumen":"A measurement of the Lambda_b lifetime and mass in the decay channel Lambda_b -&gt; J\/psi(mu^+ mu^-) Lambda^0(p pi^-) is presented. The analysis uses a signal sample of about 2200 Lambda_b and anti-Lambda_b decays that are reconstructed in 4.9 fb^-1 of ATLAS pp collision data collected in 2011 at the LHC center-of-mass energy of 7 TeV. A simultaneous mass and decay time maximum likelihood fit is used to extract the Lambda_b lifetime and mass. They are measured to be tau(Lambda_b) = 1.449 +\/- 0.036(stat) +\/- 0.017(syst) ps and m(Lambda_b) = 5619.7 +\/- 0.7(stat) +\/- 1.1(syst) MeV.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88429,"idioma_id":4,"titulo":"Search for magnetic monopoles in s&#8730;=7 TeV pp collisions with the ATLAS detector","resumen":"This Letter presents a search for magnetic monopoles with the ATLAS detector at the CERN Large Hadron Collider using an integrated luminosity of 2.0&#8201;&#8201;fb-1 of pp collisions recorded at a center-of-mass energy of &#8730;s=7&#8201;&#8201;TeV. No event is found in the signal region, leading to an upper limit on the production cross section at 95% confidence level of 1.6\/&#1013;&#8201;&#8201;fb for Dirac magnetic monopoles with the minimum unit magnetic charge and with mass between 200 GeV and 1500 GeV, where &#1013; is the monopole reconstruction efficiency. The efficiency &#1013; is high and uniform in the fiducial region given by pseudorapidity |&#951;|<1.37 and transverse kinetic energy 600\u2013700<Ekinsin&#8289;&#952;<1400&#8201;&#8201;GeV. The minimum value of 700 GeV is for monopoles of mass 200 GeV, whereas the minimum value of 600 GeV is applicable for higher mass monopoles. Therefore, the upper limit on the production cross section at 95% confidence level is 2 fb in this fiducial region. Assuming the kinematic distributions from Drell-Yan pair production of spin-1\/2 Dirac magnetic monopoles, the efficiency is in the range 1%\u201310%, leading to an upper limit on the cross section at 95% confidence level that varies from 145 fb to 16 fb for monopoles with mass between 200 GeV and 1200 GeV. This limit is weaker than the fiducial limit because most of these monopoles lie outside the fiducial region.","palabras_clave":"Magnetic monopoles|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88430,"idioma_id":4,"titulo":"Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at $\\sqrt{s}=7$ TeV with the ATLAS detector","resumen":"A search for direct pair production of supersymmetric top squarks (stop_1) is presented, assuming the stop_1 decays into a top quark and the lightest supersymmetric particle, neutralino_1, and that both top quarks decay to purely hadronic final states. A total of 16 (4) events are observed compared to a predicted Standard Model background of 13.5+3.7-3.6 (4.4+1.7-1.3) events in two signal regions based on int(Ldt) = 4.7 fb^-1 of pp collision data taken at sqrt(s) = 7 TeV with the ATLAS detector at the LHC. An exclusion region in the stop_1 versus neutralino_1 mass plane is evaluated: 370<m(stop_1)<465 GeV is excluded for m(neutralino_1)~0 GeV while m(stop_1)=445 GeV is excluded for m(neutralino_1)<=50 GeV","palabras_clave":"SUSY|top quark|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88431,"idioma_id":4,"titulo":"Search for direct top squark pair production in final states with one isolated lepton, jets, and missing transverse momentum in $\\sqrt{s}=7$ TeV $pp$ collisions using 4.7 $fb^{-1}$ of ATLAS data","resumen":"A search is presented for direct top squark pair production in final states with one isolated electron or muon, jets, and missing transverse momentum in proton-proton collisions at sqrt(s) = 7 TeV. The measurement is based on 4.7 fb-1 of data collected with the ATLAS detector at the LHC. Each top squark is assumed to decay to a top quark and the lightest supersymmetric particle (LSP). The data are found to be consistent with Standard Model expectations. Top squark masses between 230 GeV and 440 GeV are excluded with 95% confidence for massless LSPs, and top squark masses around 400 GeV are excluded for LSP masses up to 125 GeV.","palabras_clave":"stop|SUSY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88432,"idioma_id":4,"titulo":"ATLAS search for a heavy gauge boson decaying to a charged lepton and a neutrino in pp collisions at s&#8730;=7 TeV","resumen":"The ATLAS detector at the LHC is used to search for high-mass states, such as heavy charged gauge bosons (W'), decaying to a charged lepton (electron or muon) and a neutrino. Results are presented based on the analysis of pp collisions at a centre-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.7 fb-1. No excess beyond Standard Model expectations is observed. A W' with Sequential Standard Model couplings is excluded at the 95% credibility level for masses up to 2.55 TeV. Excited chiral bosons (W*) with equivalent coupling strength are excluded for masses up to 2.42 TeV.","palabras_clave":"heavy:gauge|search|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88433,"idioma_id":4,"titulo":"ATLAS search for new phenomena in dijet mass and angular distributions using pp collisions at s&#8730;=7 TeV","resumen":"Mass and angular distributions of dijets produced in LHC proton-proton collisions at a centre-of-mass energy s&#8730;=7 TeV have been studied with the ATLAS detector using the full 2011 data set with an integrated luminosity of 4.8 fb&#8722;1. Dijet masses up to ~ 4.0 TeV have been probed. No resonance-like features have been observed in the dijet mass spectrum, and all angular distributions are consistent with the predictions of QCD. Exclusion limits on six hypotheses of new phenomena have been set at 95% CL in terms of mass or energy scale, as appropriate. These hypotheses include excited quarks below 2.83 TeV, colour octet scalars below 1.86 TeV, heavy W bosons below 1.68 TeV, string resonances below 3.61 TeV, quantum black holes with six extra space-time dimensions for quantum gravity scales below 4.11 TeV, and quark contact interactions below a compositeness scale of 7.6 TeV in a destructive interference scenario.","palabras_clave":"Dijets|New phenomena|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88434,"idioma_id":4,"titulo":"Search for R-parity-violating supersymmetry in events with four or more leptons in s&#8730;=7 TeV pp collisions with the ATLAS detector","resumen":"A search for new phenomena in final states with four or more leptons   (electrons or muons) is presented. The analysis is based on 4.7 fb&#8722;1 of                                   s&#8730;=7TeV                                 proton-proton collisions delivered   by the Large Hadron Collider and recorded with the ATLAS detector.   Observations are consistent with Standard Model expectations in two   signal regions: one that requires moderate values of missing transverse   momentum and another that requires large effective mass. The results are   interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA\/CMSSM model, values of m                                1\/2 up to 820 GeV are excluded for 10 &lt; tan &#946; &lt; 40.","palabras_clave":"ATLAS|LHC|HEP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88435,"idioma_id":4,"titulo":"Search for anomalous production of prompt like-sign lepton pairs at s&#8730;=7 TeV with the ATLAS detector","resumen":"An inclusive search for anomalous production of two prompt, isolated leptons with the same electric charge is presented. The search is performed in a data sample corresponding to 4.7 fb&#8722;1 of integrated luminosity collected in 2011 at s&#8730;=7TeV with the ATLAS detector at the LHC. Pairs of leptons (e ± e ±, e ± &#956; ±, and &#956; ± &#956; ±) with large transverse momentum are selected, and the dilepton invariant mass distribution is examined for any deviation from the Standard Model expectation. No excess is found, and upper limits on the production cross section of like-sign lepton pairs from physics processes beyond the Standard Model are placed as a function of the dilepton invariant mass within a fiducial region close to the experimental selection criteria. The 95% confidence level upper limits on the cross section of anomalous e ± e ±, e ± &#956; ±, or &#956; ± &#956; ± production range between 1.7 fb and 64 fb depending on the dilepton mass and flavour combination.","palabras_clave":"Anomalous lepton production|ATLAS|New physics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88436,"idioma_id":4,"titulo":"Search for doubly-charged Higgs bosons in like-sign dilepton final states at s&#8730;=7 TeV with the ATLAS detector","resumen":"A search for doubly-charged Higgs bosons decaying to pairs of electrons and\/or muons is presented. The search is performed using a data sample corresponding to an integrated luminosity of 4.7 fb-1 of pp collisions at sqrt(s) = 7 TeV collected by the ATLAS detector at the LHC. Pairs of prompt, isolated, high-pT leptons with the same electric charge (ee, emu, mumu) are selected, and their invariant mass distribution is searched for a narrow resonance. No significant excess over Standard Model background expectations is observed, and limits are placed on the cross section times branching ratio for pair production of doubly-charged Higgs bosons. The masses of doubly-charged Higgs bosons are constrained depending on the branching ratio into these leptonic final states. Assuming pair production, coupling to left-handed fermions, and a branching ratio of 100% for each final state, masses below 409 GeV, 375 GeV, and 398 GeV are excluded for ee, emu, mumu, respectively.","palabras_clave":"higgs|charged|ATLAS|search"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88437,"idioma_id":4,"titulo":"Measurement of Z boson Production in Pb+Pb Collisions at sNN&#8722;&#8722;&#8722;&#8722;&#8730;=2.76 TeV with the ATLAS Detector","resumen":"The ATLAS experiment has observed 1995 Z boson candidates in data corresponding to 0.15&#8201;&#8201;nb-1 of integrated luminosity obtained in the 2011 LHC Pb+Pb run at &#8730;sNN=2.76&#8201;&#8201;TeV. The Z bosons are reconstructed via dielectron and dimuon decay channels, with a background contamination of less than 3%. Results from the two channels are consistent and are combined. Within the statistical and systematic uncertainties, the per-event Z boson yield is proportional to the number of binary collisions estimated by the Glauber model. The elliptic anisotropy of the azimuthal distribution of the Z boson with respect to the event plane is found to be consistent with zero.","palabras_clave":"Z boson|Heavy ion collisions|ATLAS|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88438,"idioma_id":4,"titulo":"A Massive Particle Consistent with the Standard Model Higgs Boson observed with the ATLAS Detector at the Large Hadron Collider","resumen":"Nearly 50 years ago, theoretical physicists proposed that a field permeates the universe and gives energy to the vacuum. This                        field was required to explain why some, but not all, fundamental particles have mass. Numerous precision measurements during                        recent decades have provided indirect support for the existence of this field, but one crucial prediction of this theory has                        remained unconfirmed despite 30 years of experimental searches: the existence of a massive particle, the standard model Higgs                        boson. The ATLAS experiment at the Large Hadron Collider at CERN has now observed the production of a new particle with a                        mass of 126 giga\u2013electron volts and decay signatures consistent with those expected for the Higgs particle. This result is                        strong support for the standard model of particle physics, including the presence of this vacuum field. The existence and                        properties of the newly discovered particle may also have consequences beyond the standard model itself.","palabras_clave":"HIGGS|BOSON|DISCOVERY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88439,"idioma_id":4,"titulo":"Search for a heavy narrow resonance decaying to e&#956;, e&#964;, or &#956;&#964; with the ATLAS detector in s&#8730;=7 TeV pp collisions at the LHC","resumen":"This letter presents the results of a search for a heavy particle decaying into an e mu, e tau, or mu tau final state in pp collisions at sqrt(s) = 7 TeV. The data were recorded with the ATLAS detector at the LHC during 2011 and correspond to an integrated luminosity of 4.6\/fb. No significant excess above the Standard Model expectation is observed, and exclusions at 95% confidence level are placed on the cross section times branching ratio for the production of an R-parity-violating supersymmetric tau sneutrino. These results considerably extend constraints from Tevatron experiments.","palabras_clave":"RPV|SUSY|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88440,"idioma_id":4,"titulo":"Nuclear receptor coactivator RAC3 inhibits autophagy","resumen":"PRIMER AUTORÍA COMPARTIDA. - RAC3 is an oncogene naturally overexpressed in several tumors.  Besides its role as coactivator, it can exert several protumoral  cytoplasmic actions. Autophagy was found to act either as a  tumor suppressor during the early stages of tumor development,  or as a protector of the tumor cell in later stages under hypoxic  conditions. We found that RAC3 overexpression inhibits autophagy  when induced by starvation or rapamycin and involves  RAC3 nuclear translocation-dependent and -independent mechanisms.  Moreover, hypoxia inhibits the RAC3 gene expression  leading to the autophagy process, allowing tumor cells to survive  until angiogenesis occurs. The interplay between RAC3, hypoxia,  and autophagy could be an important mechanism for tumor  progression and a good target for a future anticancer therapy.","palabras_clave":"AUTOPHAGY|HYPOXIA|RAC3|RAPAMYCIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88441,"idioma_id":4,"titulo":"Age-specific thyroid hormone and TSH reference intervals for a pediatric and adolescent population","resumen":"&nbsp;Ver texto completo","palabras_clave":"TSH|thyroid hormone"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88442,"idioma_id":4,"titulo":"Alterations in c-Src\/HER1 and estrogen receptor &#945; signaling pathways in mammary gland and tumors of hexachlorobenzene-treated rats","resumen":"Hexachlorobenzene (HCB) is an organochlorine pesticide that acts as an endocrine disruptor in humans and rodents. The development of breast cancer strongly depends on endocrine conditions modulated by environmental factors. We have demonstrated that HCB is a tumor co-carcinogen in rats and an inducer of proliferation in MCF-7 cells, in an estrogen receptor &#945; (ER&#945;)-dependent manner, and of migration in MDA-MB-231 breast cancer cell line. In the present study, we examined HCB effect on c-Src\/human epidermal growth factor receptor (HER1) and ER&#945; signaling pathways in mammary glands and in Nnitroso-N-methylurea (NMU)-induced mammary tumors in rats. Furthermore, we evaluated histopathological changes and serum hormone levels. Rats were separated into four groups: control, HCB (100 mg\/kg b.w.), NMU (50 mg\/kg b.w.) and NMU-HCB. Our data show that HCB increases c-Src and HER1 activation, c-Src\/HER1 association, and Y699-STAT5b and ERK1\/2 phosphorylation in mammary glands. HCB also enhances Y537-ER&#945; phosphorylation and ER&#945;\/c-Src physical interaction. In tumors, HCB also induces cSrc and HER1 activation, c-Src\/HER1 association, as well as T308-Akt and Y699-STAT5b phosphorylation. In addition, the pesticide increases ER&#945; protein content and decreases p-Y537-ER&#945; levels and ER&#945;\/c-Src association in tumors. HCB increases serum 17-beta estradiol and prolactin contents and decreases progesterone, FSH and LH levels in rats without tumors, while the opposite effect was observed in rats with tumors. Taken together, our results indicate that HCB induces an estrogenic effect in mammary gland, increasing c-Src\/HER1 and ER&#945; signaling pathways. HCB stimulates c-Src\/HER1 pathway, but decreases ER&#945; activity in tumors, appearing to shift them towards a higher malignancy phenotype.","palabras_clave":"Hexachlorobenzene|Mammary gland|Tumor promotion|Estrogen receptor alfa|HER1|c-Src"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88443,"idioma_id":4,"titulo":"IL-17 and IFN-gamma expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease","resumen":"Th1 lymphocytes are crucial in the immune response against Mycobacterium tuberculosis. Nevertheless, IFN-&#947; alone is not sufficient in the complete eradication of the bacteria, suggesting that other cytokines might be required for pathogen removal. Th17 cells have been associated with M. tuberculosis infection, but the role of IL-17-producing cells in human TB remains to be understood. Therefore, we investigated the induction and regulation of IFN-&#947; and IL-17 during the active disease. TB patients were classified as High and Low Responder individuals according to their T cell responses against the antigen, and cytokine expression upon M. tuberculosis stimulation was investigated in peripheral blood and pleural fluid. Afterwards, the potential correlation among the proportions of cytokine-producing cells and clinical parameters was analyzed. In TB patients, M. tuberculosis induced IFN-&#947; and IL-17, but in comparison with BCG-vaccinated healthy donors, IFN-&#947; results were reduced significantly, and IL-17 was markedly augmented. Moreover, the main source of IL-17 was represented by CD4(+)IFN-&#947;(+)IL-17(+) lymphocytes, a Th1\/Th17 subset regulated by IFN-&#947;. Interestingly, the ratio of antigen-expanded CD4(+)IFN-&#947;(+)IL-17(+) lymphocytes, in peripheral blood and pleural fluid from TB patients, was correlated directly with clinical parameters associated with disease severity. Indeed, the highest proportion of CD4(+)IFN-&#947;(+)IL-17(+) cells was detected in Low Responder TB patients, individuals displaying severe pulmonary lesions, and longest length of disease evolution. Taken together, the present findings suggest that analysis of the expansion of CD4(+)IFN-&#947;(+)IL-17(+) T lymphocytes in peripheral blood of TB patients might be used as an indicator of the clinical outcome in active TB.","palabras_clave":"tuberculosis|Th1\/Th17 cells|cytokines|costimulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88444,"idioma_id":4,"titulo":"Simulation   of   non-volatile   memory   cell   using   chalcogenide   glasses","resumen":"In this paper, a non-volatile memory cell of Te-based chalcogenide material is proposed and modeled. It is formed by layers of three materials: an insulating material, a conductor and a sensitive material: Te-based chalcogenide material. A 2D model using a finite element method has been developed for the simulation of the thermal behaviour of the cell. Temporal evolution of temperature maps is obtained. The model is applied to alloys of the Ge?Sb?Te system. The computed results allow us to understand the role played by the variables involved (thickness of different layers, cell radius, composition of the chalcogenide glass) in order to optimize the cell structure.","palabras_clave":"Memorias no volatiles|Simulacion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88446,"idioma_id":4,"titulo":"Effects of UV radiation on the taxonomic composition of natural bacterioplankton communities from Bahía Engaño (Patagonia, Argentina)","resumen":"In order to gain insights into the effects of solar ultraviolet radiation (UVR, 280?400 nm) on the composition of marine bacterioplankton communities from South Atlantic waters ? Bahía Engaño (Patagonia, Argentina), we performed microcosms experiments during the Austral summer of 2010. Water samples were exposed to three solar radiation treatments in 25 L microcosms during 8 days: PAR + UV-A + UV-B (280?700 nm; PAB treatment), PAR + UV-A (320?700 nm; PA treatment), and PAR only (400?700 nm; P treatment). The taxonomic composition of the bacterial communities, at the beginning and at the end of the experiment, were studied by the analyses of 16S rDNA gene libraries. Multivariate and phylogenetic analyses demonstrated substantial differences in the community composition so that the samples exposed to PAR and PAR + UV-A presented more similar taxa assemblages among them than compared to the PAR + UV-A + UV-B exposed one. Our results indicate that overall, exposure to different radiation treatments can shape the taxonomic composition of marine bacterial populations, grown in microcosms, from this Patagonian area.","palabras_clave":"UVR|DNA|BACTERIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88447,"idioma_id":4,"titulo":"Motility and photosynthetic responses of the green microalga Tetraselmis subcordiformis to visible and UV light levels","resumen":"To test the effects of photosynthetic active radiation (PAR, 400?700 nm) and ultraviolet radiation (UVR, 280?400 nm) on phototaxis and photosynthesis of free swimming microalgae, experiments were performed with Tetraselmis subcordiformis (Wille) Butcher under a solar simulator. In particular, we evaluated the effects of different PAR levels and radiation regimes (i.e., PAR only and PAR+UVR) on those two processes.We found that the cells preferred to move to a particular area (e.g., receiving 100Wm-2 PAR) with little photochemical suppression or inhibition of carbon fixation. Adding UV-A to high PAR decreased its swimming capacity and photosynthetic capability, and further adding UV-B led to more inhibition. The suppression of the moving capability of T. subcordiformis was reversible but the cells exposed to PAR combined with UVR needed longer time intervals to recover their motility as compared with those irradiated only with PAR. Based on the above results, we postulate that in nature, the motile capability and photosynthesis of free swimming the green microalga might be impaired by enhanced solar UVR. On the other hand, the cells can reduce the damage caused by high irradiances (and even get the optimum light level for photosynthesis) by a behavioral swimming response","palabras_clave":"MOTILITY|PHOTOSYNTHESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88448,"idioma_id":4,"titulo":"'A genome-wide regulatory framework identifies maize Pericarp Color1 (P1) controlled genes'","resumen":"Pericarp Color1 (P1) encodes an R2R3-MYB transcription factor   responsible for the accumulation of insecticidal flavones in maize (Zea   mays) silks and red phlobaphene pigments in pericarps and other floral   tissues, which makes P1 an important visual marker. Using genome-wide   expression analyses (RNA sequencing) in pericarps and silks of plants   with contrasting P1 alleles combined with chromatin immunoprecipitation   coupled with high-throughput sequencing, we show here that the   regulatory functions of P1 are much broader than the activation of genes   corresponding to enzymes in a branch of flavonoid biosynthesis. P1   modulates the expression of several thousand genes, and ~1500 of them   were identified as putative direct targets of P1. Among them, we   identified F2H1, corresponding to a P450 enzyme that converts naringenin   into 2-hydroxynaringenin, a key branch point in the P1-controlled   pathway and the first step in the formation of insecticidal C-glycosyl   flavones. Unexpectedly, the binding of P1 to gene regulatory regions can   result in both gene activation and repression. Our results indicate   that P1 is the major regulator for a set of genes involved in flavonoid   biosynthesis and a minor modulator of the expression of a much larger   gene set that includes genes involved in primary metabolism and   production of other specialized compounds.","palabras_clave":"P1|flavonoides|maiz|regulación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88449,"idioma_id":4,"titulo":"Analysis of the P1 promoter in response to UV-B radiation in allelic variants of high-altitude maize","resumen":"Background Plants living at high altitudes are typically exposed to elevated UV-B radiation, and harbor mechanisms to prevent the induced damage, such as the accumulation of UV-absorbing compounds. The maize R2R3-MYB transcription factor P1 controls the accumulation of several UV-B absorbing phenolics by activating a subset of flavonoid biosynthetic genes in leaves of maize landraces adapted to high altitudes.   Results Here, we studied the UV-B regulation of P1 in maize leaves of high altitude landraces, and we investigated how UV-B regulates P1binding to the CHS promoter in both low and high altitude lines. In addition, we analyzed whether the expansion in the P1 expression domain between these maize landraces and inbred lines is associated to changes in the molecular structure of the proximal promoter, distal enhancer and first intron of P1. Finally, using transient expression experiments in protoplasts from various maize genotypes, we investigated whether the different expression patterns of P1 in the high altitude landraces could be attributed to trans- or cis-acting elements.  Conclusions Together, our results demonstrate that, although differences in cis-acting elements exist between the different lines under study, the different patterns of P1 expression are largely a consequence of effects in trans.","palabras_clave":"P1|flavonoid|UV-B|maize"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88450,"idioma_id":4,"titulo":"Evolution and expression of tandem duplicated maize flavonol synthase genes","resumen":"Flavonoids are specialized compounds widely distributed and with diverse functions throughout the plant kingdom and with several benefits for human health. In particular, flavonols, synthesized by flavonol synthase (FLS), protect plants against UV-B radiation and are essential for male fertility in maize and other plants. We have recently characterized a UV-B inducible ZmFLS1, corresponding to the first to be described in monocot plants. Interestingly, the new assembly of the B73 maize genome revealed the presence of a second putative FLS gene (ZmFLS2), with very high identity with ZmFLS1. ZmFLSs expression was analyzed in different maize tissues, and by combining EMSA assays and transient expression experiments, we show that both genes are direct targets of anthocyanin (C1\/PL1 + R\/B) and 3-deoxy flavonoid (P1) transcriptional regulators. ZmFLS expression analyses show higher levels of both transcripts in high altitude landraces than inbred lines, and both genes are regulated by UV-B radiation in all lines analyzed. Moreover, the high sequence conservation of the ZmFLS promoters between maize lines suggests that the differences observed in ZmFLS expression are due to allelic variations in the transcription factors that regulate their activities. Finally, we generated pFLS1::FLS1-RFP transgenic plants and analyzed ZmFLS1 expression in different maize tissues; we found that this enzyme is localized in the ER and the perinuclear region.","palabras_clave":"flavonol synthase"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88451,"idioma_id":4,"titulo":"Bioseparation of alpha-amylase by forming insoluble complexes with polyacrylate from a culture of Aspergillus oryzae grown in agricultural wastes","resumen":"Abstract:  Precipitation of insoluble complexes between alpha-amylase from Aspergillus oryzae and polyacrylic acid was studied by us in a previous work as a strategy of protein concentration and purification. Here we studied the effect of these polyelectrolytes on the stability of the enzyme at the pH of higher interaction (3.00), as well as the stability of the precipitates formed after applied the above methodology. The polymers showed a stabilizing effect on the activity of alpha-amylase at pH 3.00, given the kinetic constants achieved when adjusting the experimental data to a process of first order inactivation: 2.20e-2 ± 2e-3 for alpha-amylase alone, 7.7e-3 ± 3e-4 and 8.2e-3 ± 2e-4 for polyacrylic acid 240,000 and 100,000, respectively.  Also, this stabilizing effect is intensified when complexes are in the solid precipitated form before redissolve, given the lower kinetic constants of inactivation obtained: 1.7e-3 ± 2e-4 and 2.6e-3 ± 2e-4 for polyacrylic acid 240,000 and 100,000, respectively.  In a subsequent step, a strain of A. oryzae was used as enzymatic source. In order to stimulate alpha-amylase production and secretion by the microorganism, we used a minimum culture medium with wheat processing residues as substrate. This has economic and environmental benefits, because of the recycling of agricultural wastes. This culture showed a maximum productivity at the fourth day of incubation.  When the technique of concentration and purification of alpha-amylase was implemented from this culture we obtained purification factors around two and recoveries around 70%. These results demonstrate that this methodology is suitable for the concentration and purification of alpha-amylase from A. oryzae. Besides, it is inexpensive since it uses agricultural materials without commercial value.","palabras_clave":"PRECIPITATION|INSOLUBLE COMPLEXES|ALPHA-AMYLASE|POLYACRYLIC ACID|POLYELECTROLYTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88452,"idioma_id":4,"titulo":"Analysis of the interactions between Eudragit L100 and porcine pancreatic trypsin by calorimetric techniques","resumen":"Flexible-chain polymers with charge (polyelectrolytes) can interact with globular proteins with a net charge opposite to the charge of the polymers forming insoluble complexes polymer-protein. In this work, the interaction between the basic protein trypsin and the anionic polyelectrolyte Eudragit® L100 was studied by using isothermal calorimetric titrations and differential scanning calorimetry. Turbidimetric assays allowed determining that protein-polymer complex was insoluble at pH below 5 and the trypsin and Eudragit® L100 concentrations required forming the insoluble complex. DSC measurements showed that the Tm and denaturalization heat of trypsin increased in the polymer presence and the complex unfolded according to a two-state model. ÄH° and ÄS° binding parameters obtained by ITC were positives agree with hydrophobic interaction between trypsin and polymer. However, ionic strength of 1.0 M modified the insoluble complex formation. We propose a mechanism of interaction between Eudragit® L100 and trypsin molecules that involves both hydrophobic and electrostatic interactions. Kinetic studies of complex formation showed that the interaction requires less than one minute achieving the maximum quantity of complex. Finally, a high percentage of active trypsin was precipitated (approximately 76 % of the total mass of protein). These findings could be useful in different protocols such as a protein isolation strategy, immobilization or purification of a target protein.       ","palabras_clave":"TRYPSIN|ISOTHERMAL TITRATION CALORIMETRY|DIFFERENTIAL SCANNING CALORIMETRY|PROTEIN-POLYMER INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88453,"idioma_id":4,"titulo":"Pancreatic serine protease extraction by affinity partition using a free triazine dye","resumen":"Affinity partitioning combines the partitioning behavior of biological macromolecules in aqueous twophase systems with the principle of biorecognition. Among the numerous substances that have been evaluated as ligands, the reactive dyes constitute a group of low cost textile dyes which have proved to act as biomimetic ligands for many enzymes. The ability of reactive yellow 2 (RY2) to interact with trypsin (TRP) and chymotrypsin (ChTRP) and its behavior in aqueous two-phase systems formed by polyethylene glycol (PEG) and sodium citrate (NaCit) \u2013 were investigated. Different variables such as PEG molecular weight, tie line length and dye concentration were analyzed. RY2 showed to bind specifically to both TRP and ChTRP with affinity constants near to 103M&#8722;1. Its partition equilibrium is practically displaced to the top phase in systems formed by PEG of different molecular weight. Addition of this dye to PEG 8000\/NaCit systems until a final concentration of 0.196% (w\/w) induced an increase in TRP and ChTRP partition coefficients of at least 2 times over that in the absence of the ligand. These findings demonstrate that RY2 fulfils all the requirements to be considered as an affinity ligand in aqueous two-phase partitioning of TRP and ChTRP.","palabras_clave":"Af&#64257;nity partitioning|aqueous two phase systems|textile dyes|trypsin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88454,"idioma_id":4,"titulo":"Role of bovine herpesvirus type 5 (BoHV-5) in diseases of cattle. Recent findings on BoHV-5 association with genital disease","resumen":"Bovine herpesvirus type 5 (BoHV-5) belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. This virus is a major causative agent of non-suppurative meningoencephalitis in young cattle. It was first isolated in 1962 from a neurological disease outbreak in Australia. BoHV-5 is genetically and antigenically related to bovine herpesvirus type 1 (BoHV-1), a highly prevalent virus responsible for respiratory and genital disease in cattle. Initially, BoHV-5 was considered a subtype of BoHV-1 (BoHV-1.3). However, the exclusive presentation of outbreaks of neurological disease suggested that the virus was a new agent with characteristics of neuropathogenicity. Even though both are neurotropic viruses, only BoHV-5 is capable of replicating extensively in the central nervous system and inducing neurological disease. Occasionally, encephalitis caused by BoHV-1 has been reported. Like other alpha-herpesviruses, BoHV-5 can establish latency in nervous ganglia and, by stress factors or glucocorticoid treatment, latent virus can be reactivated. During episodes of reactivation, the virus is excreted in nasal, ocular and genital secretions and transmitted to other susceptible hosts. Recently, BoHV-5 has been associated with infection of the reproductive tract. The virus has been isolated and the presence of viral DNA has been demonstrated in semen samples from Brazil and Australia and natural transmission of the virus through contaminated semen has also been described. Embryos and oocytes are permissive for BoHV-5 infection and BoHV-5 DNA has been detected in the central nervous system of aborted fetuses. The objective of this review is to compile the limited information on the recent association between BoHV-5 and reproductive disorders in cattle.","palabras_clave":"BoHV-5|Reproductive disorders|Semen"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88455,"idioma_id":4,"titulo":"ICOS, SLAM and PD-1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV-related illness with pulmonary tuberculosis","resumen":"bACKGROUND: Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis (Mtb), we assessed basal and Mtb-induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death-1 (PD-1) on T lymphocytes from HIV-positive individuals coinfected with TB, HIV-positive subjects, TB patients and healthy donors (HD).  FINDINGS:  HIV-TB patients showed increased ICOS, SLAM and PD-1 basal levels on T lymphocytes, whereas HIV-positive individuals displayed elevated levels of SLAM and PD-1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb-stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD-1 levels.  CONCLUSIONS:  These data show the immune deregulation that takes place during the immune response against TB in different study populations.","palabras_clave":"TUBERCULOSIS|HIV|COSTIMULATORY MOLECULES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88456,"idioma_id":4,"titulo":"Community structure of artificial container-breeding flies (Insecta: Diptera) in relation to the urbanization level","resumen":"The changes in the community structure of flies breeding in small artificial containers along environments of different urbanization level were assessed at two spatial scales; i.e. patch and landscape. A total of 8400 water-filled flower vases were inspected in 14 cemeteries from temperate Argentina. A total of 267,013 larvae were collected in 31.1% of the inspected containers. Twenty-four species belonging to eleven Diptera families were identified. Four species (from Muscidae, Culicidae, Chironomidae, and Ceratopogonidae) represented 95.6% of the larvae collected and 93.2% of the occupied containers. For the local spatial scale, i.e. patches within cemeteries, there was no evidence that the community structure differs between open green spaces and densely built areas. For the landscape spatial scale, i.e. among cemeteries surrounded by different urbanization levels, different patterns were detected. The percentage of containers harboring larvae and the abundance (total and per container) showed a clear peak at intermediatelevels of urbanization (20\u201340% of impervious area). The species richness and composition weresimilar along the gradient. Our results suggest that the urbanization level affects the studied community depending on the spatial scale.&nbsp;","palabras_clave":"Community structure|Biodiversity|Urban environment|Culicidae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88457,"idioma_id":5,"titulo":"De la Quema al parque: Notas sobre las políticas urbanas en la dictadura y la producción de pequeños consensos cotidianos en la Ciudad de Buenos Aires (1976-1983)","resumen":"Este artículo analiza las transformaciones ocurridas entre 1976 y 1983 en el barrio de Villa Soldati de la Ciudad de Buenos Aires, a partir de un doble registro: el de las políticas públicas que impactaron en el barrio y las percepciones que de ellas tuvieron sus habitantes. Para ello, por un lado se reconstruyen los cambios producidos a partir de las políticas públicas que fueron transformando ese territorio de la ciudad, poniendo énfasis en la etapa de la última dictadura militar, especialmente en el cierre de los basurales y la urbanización de esas zonas; por el otro, en la manera en que los habitantes del barrio vivieron dichas transformaciones. Recuperar las perspectivas de los habitantes permite mostrar cómo esas políticas urbanas fueron significadas por los habitantes a partir de su experiencia microterritorial y abordar la complejidad de los procesos de construcción y experienciación de la ciudad.","palabras_clave":"BUENOS AIRES|POLÍTICAS URBANAS|CIUDAD BLANCA|CIUDAD VERDE|EXPERIENCIA MICROTERRITORIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88458,"idioma_id":4,"titulo":"A Seismological and Petrological crustal model for the Southwest of the Sierra de Pie de Palo,  San Juan (Argentina)","resumen":"A seismic velocity analysis from teleseismic receiver functions recorded in the southwestern fank of the Sierra de Pie de Palo (Western Sierras Pampeanas, Argentina), is compared with seismic properties directly calculated from lithological composition. The seismological results show an upper layer located in the first 13 km depth. A deeper contrast in seismic velocities is found at a depth of 28 km; the petrological results indicate a composition compatible with observed greenschist and amphibolite facies mafic rocks up to this depth. The receiver function measurements at 13 km and 28 km depths could be interpreted as two potential décollement levels that might have favoring a mechanism to thicken the whole crust, which produces a receiver function Moho signal located at 47 km depth. In addition, the lower crust between 28 km and 47 km exhibits high seismic P-wave velocities and Vp\/Vs ratio (> 1.80) that are representative of a densification consistent with upper amphibolite to granulite\/ecoglite facies lithologies. Based on these results, the combined petrological and seismological analyses suggest the continuation of the same mafic-crust outcropping lithologies into the lower levels of the 47-km thickened crust, which could be part of the Pie de Palo Complex ophiolite belt or the Precordillera basement.","palabras_clave":"Crustal structure|Moho|Receiver functions|Sierras Pampeanas|Ophiolite."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88459,"idioma_id":4,"titulo":"Evaluation of the sensitivity and specificity of bovine tuberculosis diagnostic tests in naturally infected cattle herds using a Bayesian approach","resumen":"Test-and-slaughter strategies have been the basis of bovine tuberculosis (BT) eradication programs worldwide; however, eradication efforts have not succeeded in certain regions, and imperfect sensitivity and specificity of applied diagnostic techniques have been deemed as one of the possible causes for such failure. Evaluation of tuberculosis diagnostic tools has been impaired by the lack of an adequate gold standard to define positive and negative individuals. Here, a Bayesian approach was formulated to estimate for the first time sensitivity (Se) and specificity (Sp) of the tests [single intradermal tuberculin (SIT) test, and interferon-gamma (IFN-g) assay] currently used in Spain. Field data from the first implementation of IFN-g assay (used in parallel with SIT test 2\u20136 months after a first disclosure SIT test) in infected beef, dairy and bullfighting cattle herds from the region of Castilla and Leon were used for the analysis. Model results suggested that in the described situation: (i) Se of SIT test was highly variable (40.1\u201392.2% for severe interpretation, median = 66\u201369%), and its Sp was high (&gt;99%) regardless interpretation criteria; (ii) IFN-g assay showed a high Se (median = 89\u201390% and 83.5% for 0.05 and 0.1 cut-off points respectively) and an acceptable Sp (85.7% and 90.3% for 0.05 and 0.1 thresholds) and (iii) parallel application of both tests maximized the combined Se (95.6% using severe SIT and 0.05 cut-off point in the IFN-g assay). These results support the potential use of the IFN-g assay as an ancillary technique for routine BT diagnosis.","palabras_clave":"tuberculosis|cattle|diagnostic tests"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88460,"idioma_id":4,"titulo":"Crustal structure of the Eastern Sierras Pampeanas of Argentina using high frequency local receiver functions","resumen":"The Eastern Sierras Pampeanas are basement cored outcrops uplifted in the Andean foreland where the easternmost segment of the Pampean flat slab segment starts dipping more steeply into the deeper mantle. These  ranges of central Argentina known as the Sierras de Córdoba have an enriched-quartz composition and are bounded by a series of reverse faults. Different models have been suggested to represent the style of the thick-skinned deformation in this area. However the overall structure linking the exposed faults and terrane boundaries with their probable continuation at depth is unknown. In this paper we present images of the  crustal structure beneath the Sierras de Córdoba using the common conversion point stacking method of high frequency local receiver functions recorded by the ESP broadband seismic array. The work consists of two transects located around 31°S and 32°S across the Sierras de Córdoba. The results show a consistent sharp Moho signal associated with a high contrast in seismic velocities in good agreement with the granitic  character of the crust lying above the mafic upper mantle. The Moho morphology varies exhibiting thicknesses of 38 km in the west to 35 km in the east with a vertical shifting under the Sierra Chica. We relate  this variable character to the presence of the boundary between the Pampia terrane and the Rio de La Plata craton. Our results for the intra-crustal structure indicate the presence of three discontinuities in the northern transect and at least two discontinuities in the southern transect. These discontinuities appear vertically displaced beneath the surface traces of the major range bounding faults providing evidence for the continuation to mid-crustal depths of the exposed reverse faults. Thus, the reverse faults seem to have displaced several horizontal intra-crustal interfaces. Finally in the lower crust we found a region which seems to be aseismic.","palabras_clave":"Receiver functions|Continental crust|Sierras Pampeanas|Flat slab|Basement outcrops|Thick-skinned deformation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88461,"idioma_id":4,"titulo":"Learning Interspecific Communicative Responses in Pampas Foxes (Lycalopex gymnocercus)","resumen":"Domestic dogs show remarkable communicative abilities in their interaction with people. These skills  maybe explained by the interaction between the domestication process and learning experiences during  ontogeny. Studies carried out on other species of canids, which have not been domesticated are relevant  to this topic. The purpose of this article is to study the effect of instrumental learning on captive Pampas  foxes? (Lycalopex gymnocercus) communicative responses to humans. Seven foxes were tested in a conflict  situation involving food within sight but out of their reach. In these situations dogs typically gaze at the  human face to ask for food. In Study 1, there was an increase in gaze duration as a consequence of  reinforcement and a decrease during extinction, when animals did not receive any more food. In Study 2,  all of the four foxes tested successfully followed proximal pointing gesture to find hidden food. When a  distal pointing cue was given, three out of four followed it in the first session and one in the second session.  These results are consistent with those previously found in dogs, and suggest that learning experiences  allow the development of communicative skills, even in not domesticated canid species.","palabras_clave":"CANIDS|INTERSPECIFIC COMMUNICATION|LEARNING|PAMPA´FOXES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88462,"idioma_id":4,"titulo":"Effects of testosterone administration and gonadectomy on incentive downshift and open field activity in rats","resumen":"Previous research showed that the effects of incentive downshift in  male rats are attenuated by a pretrial opportunity to ejaculate. Because  ejaculation raises testosterone (T) levels and has anxiolytic-like effects in  male rats, the present experiments were designed to assess the role of T and  gonadectomy (GDX) on two situations involving incentive downshift. In  consummatory successive negative contrast, a downshift from 32% to 4% sucrose  leads to consummatory suppression. T alleviates such suppression (Experiment  1), but GDX does not affect it (Experiment 3). In consummatory extinction,  animals are downshifted from 32% sucrose to an empty sipper tube. T enhances  consummatory extinction (Experiment 2), but GDX does not affect it (Experiment  4). In agreement with published results, T increases (Experiment 2) and GDX  reduces (Experiment 4) activity in the central area of an open field, thus  behaviorally validating these manipulations. The results are discussed in terms  of the anxiolytic-like properties of androgen hormones.","palabras_clave":"TESTOSTERONE|GONADECTOMY|INCENTIVE CONTRAST|CONSUMMATORY EXTINCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88463,"idioma_id":4,"titulo":"POINTING FOLLOWING IN DOGS: ARE SIMPLE OR COMPLEX COGNITIVE MECHANISMS INVOLVED?","resumen":"Domestic dogs have proved to be extremely  successful in finding hidden food following a series of  human social cues such as pointing (an extended hand and  index finger indicating the location of the reward), or body  position, among many other variants. There is controversy  about the mechanisms responsible for these communicative  skills in dogs. On the one hand, a hypothesis states that  dogs have complex cognitive processes such as a theory of  mind, which allow them to attribute intent to the human  pointing gesture. A second, more parsimonious, hypothesis  proposes that these skills depend on associative learning  processes. The purpose of this paper is to provide data that  may shed some light on the discussion by looking into two  learning processes by using an object choice task: the effect  of interference between stimuli on the preference for  human social cues and the effect of generalization of the  response to novel human social stimuli. The first study  revealed that previous training using a physical cue (container  location) may hamper the learning of a novel human  social cue (distal cross-pointing). The results of the second  study indicated stimulus generalization. Dogs learnt a  novel cue (distal cross-pointing) faster due to previous  experience with a similar cue (proximal pointing), as  compared to dogs confronted by a less similar cue (body position) or dogs with no previous experience. In sum,  these findings support the hypothesis about the important  role of associative learning in interspecific communication  mechanisms of domestic dogs.","palabras_clave":"interspecific communication|interference|generalization|learning"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88464,"idioma_id":4,"titulo":"Differential participation of phospholipase A2 isoforms during iron-induced retinal toxicity. Implications for age-related macular degeneration","resumen":"Ver sección 'Texto Completo'.","palabras_clave":"RETINA|IRON|PLA2|OXIDATIVE STRESS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88465,"idioma_id":4,"titulo":"Lactobacillus reuteri CRL1098 soluble factors modulate tumor necrosis factor alpha production in peripheral blood mononuclear cells: Involvement of lipid rafts","resumen":"The aim of the present study was to evaluate the capacity of Lactobacillus reuteri CRL1098 soluble factors (Lr-S) to modulate TNF-&#945; production in peripheral blood mononuclear cells (PBMC) and to study lipid rafts participation in this response. PBMC treated with Lr-S showed a reduced production of TNF-&#945;. In addition, Lr-S treatment activated ERK and p38 MAPK pathways in PBMC. Lipid rafts participation in the reduced production of TNF-&#945; by PBMC induced by Lr-S was verified by lipid rafts disruption with methyl-&#946;-cyclodextrin and the reduction of the Src-tyrosine kinase Lck localization in rafts. Moreover, PBMC pre-treatment with Lck inhibitors blocked the effect of Lr-S on TNF-&#945; production suggesting that activation and movilization of Lck from lipid rafts would be involved in the modulatory effect of L. reuteri CRL1098. A secreted peptide of 5,785 Da would be responsible of the modulatory effect of CRL1098 strain. This study demonstrated for the first time the lipid rafts participation in a response induced by a beneficial bacterium. Also, these results open new possibilities for investigating the molecular mechanisms involved in the interaction of probiotic bacterial extracellular compounds with immune cells.","palabras_clave":"Lactobacillus reuteri CRL1098|Lipid rafts|PBMC|TNF-&#945;|Secreted peptide"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88466,"idioma_id":5,"titulo":"Características petrográficas y geoquímicas de la Tonalita La Ovejería, borde oriental de la Sierra del Aconquija, Tafí del Valle, Tucumán: integración con la Granodiorita El Infiernillo","resumen":"La Tonalita La Ovejería constituye un cuerpo elongado de rumbo submeridional, que aflora sobre la ladera oriental de Sierra del Aconquija, al oeste de la localidad de Tafí del Valle, provincia de Tucumán, Argentina, inmediatamente al sur de otro cuerpo plutónico, de mayores dimensiones, denominado Granodiorita El Infiernillo, con el cual guardaría una estrecha relación genética. El plutón estudiado presenta una zonación determinada principalmente por diferentes granulometrías y mineralogía: en los afloramientos septentrionales se observa una roca de grano medio que, mineralógicamente, está compuesta por plagioclasa, cuarzo y escaso microclino, junto a biotita y pistacita (± turmalina). El extremo sur del intrusivo presenta un tamaño de grano fino y una asociación mineral constituida por plagioclasa, cuarzo y escaso microclino, con biotita y&nbsp; titanita. Cortando a las tonalitas se observan diques graníticos de hasta 2 metros de potencia. Geoquímicamente, presenta características calcoalcalinas y peraluminosas con un ISA entre 1,10 y 1,48. La Tonalita La Ovejería intruye a un basamento metamórfico constituido por esquistos de bajo grado metamórfico y que pertenece a la zona V de la división&nbsp; tectonometamórfica del basamento del Noroeste Argentino que se caracteriza por un aumento del metamorfismo estático, por intrusiones sintectónicas y por la intensidad en la expresión de pliegues de flujo. El emplazamiento de la Tonalita La Ovejería se habría producido durante el Paleozoico inferior y controlado estructuralmente por la Megafractura de Tafí de modo similar al de otros cuerpos intrusivos, de estrecha vinculación temporal. El intrusivo El Infiernillo está compuesto en su parte central, por granodioritas equigranulares de dos micas (± turmalina) y, en sus bordes N y NE se desarrollan tonalitas con biotita y epidoto, sin muscovita primaria, que correspondería a una facies de bordes. De acuerdo a las relaciones de campo y a las características petrográficas, geoquímicas y estructurales, la Tonalita La Ovejería correspondería también a la facies de borde del intrusivo El Infiernillo, en su límite meridional. ","palabras_clave":"PETROLOGIA|GEOQUIMICA|TONALITA LA OVEJERIA|GRANODIORITA EL INFIERNILLO|SIERRA DEL ACONQUIJA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88467,"idioma_id":4,"titulo":"Transcriptome survey of Patagonian southern beech Nothofagus nervosa (= N. alpina): assembly, annotation and molecular marker discovery","resumen":"Abstract  Background: Nothofagus nervosa is one of the most emblematic native tree species of Patagonian temperate  forests. Here, the shotgun RNA-sequencing (RNA-Seq) of the transcriptome of N. nervosa, including de novo  assembly, functional annotation, and in silico discovery of potential molecular markers to support population and  associations genetic studies, are described.  Results: Pyrosequencing of a young leaf cDNA library generated a total of 111,814 high quality reads, with an  average length of 447 bp. De novo assembly using Newbler resulted into 3,005 tentative isotigs (including  alternative transcripts). The non-assembled sequences (singletons) were clustered with CD-HIT-454 to identify  natural and artificial duplicates from pyrosequencing reads, leading to 21,881 unique singletons. 15,497 out of  24,886 non-redundant sequences or unigenes, were successfully annotated against a plant protein database. A  substantial number of simple sequence repeat markers (SSRs) were discovered in the assembled and annotated  sequences. More than 40% of the SSR sequences were inside ORF sequences. To confirm the validity of these  predicted markers, a subset of 73 SSRs selected through functional annotation evidences were successfully  amplified from six seedlings DNA samples, being 14 polymorphic.  Conclusions: This paper is the first report that shows a highly precise representation of the mRNAs diversity  present in young leaves of a native South American tree, N. nervosa, as well as its in silico deduced putative  functionality. The reported Nothofagus transcriptome sequences represent a unique resource for genetic studies  and provide a tool to discover genes of interest and genetic markers that will greatly aid questions involving  evolution, ecology, and conservation using genetic and genomic approaches in the genus.","palabras_clave":"Nothofagaceae|Forest genomics|Pyrosequencing|de novo transcriptome assembly"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88468,"idioma_id":4,"titulo":"Maize plants (Zea mays) root exudates enhance lindane removal by native Streptomyces strains","resumen":"The organochlorine pesticide (OP) lindane was removed from minimal medium (MM) by two Streptomyces native strains, while growing on maize root exudates (REs) as a primary carbon and energy source. REs supported 55 and 35% of lindane removal by Streptomyces sp. strains A5 and M7, respectively,corroborating the hypothesis that co-metabolism may be a plant\/microbe interaction important to bioremediation. In addition, residual lindane concentration was more than half of the amount in MMsupplemented with glucose compared to MM supplemented with REs, suggesting that exudates could be more appropriate carbon source to support aerobic dehalogenation of the pesticide. Lindane-degradingactivity was detected in REs, which could explain 42% of lindane removal in REs-lindane assay, without microorganisms. Because Streptomyces sp. A5 showed maximum biomass and the highest pesticide removal in REs-lindane assay, it was found to be the most promising strain regarding their future application. These results showed that phytostimulation of OP-degrading actinobacteria by maize REs are therefore likely to be a successful strategy for the remediation of lindane-contaminated environments.","palabras_clave":"Bioremediation|Lindane|Root exudates|Actinobacteria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88469,"idioma_id":4,"titulo":"Sequential Activation of Classic PKC and Estrogen Receptor &#945; Is Involved in Estradiol 17ß-D-Glucuronide-Induced Cholestasis","resumen":"            Estradiol 17ß-d-glucuronide (E17G) induces acute cholestasis in rat with endocytic internalization of the canalicular transporters bile salt export pump (Abcb11) and multidrug resistance-associated protein 2 (Abcc2). Classical protein kinase C (cPKC) and PI3K pathways play complementary roles in E17G cholestasis. Since non-conjugated estradiol is capable of activating these pathways via estrogen receptor alpha (ER&#945;), we assessed the participation of this receptor in the cholestatic manifestations of estradiol glucuronidated-metabolite E17G in perfused rat liver (PRL) and in isolated rat hepatocyte couplets (IRHC). In both models, E17G activated ER&#945;. In PRL, E17G maximally decreased bile flow, and the excretions of dinitrophenyl-glutathione, and taurocholate (Abcc2 and Abcb11 substrates, respectively) by 60% approximately; preadministration of ICI 182,780 (ICI, ER&#945; inhibitor) almost totally prevented these decreases. In IRHC, E17G decreased the canalicular vacuolar accumulation of cholyl-glycylamido-fluorescein (Abcb11 substrate) with an IC50 of 91±1µM. ICI increased the IC50 to 184±1µM, and similarly prevented the decrease in the canalicular vacuolar accumulation of the Abcc2 substrate, glutathione-methylfluorescein. ICI also completely prevented E17G-induced delocalization of Abcb11 and Abcc2 from the canalicular membrane, both in PRL and IRHC. The role of ER&#945; in canalicular transporter internalization induced by E17G was confirmed in ER&#945;-knocked-down hepatocytes cultured in collagen sandwich. In IRHC, the protection of ICI was additive to that produced by PI3K inhibitor wortmannin but not with that produced by cPKC inhibitor Gö6976, suggesting that ER&#945; shared the signaling pathway of cPKC but not that of PI3K. Further analysis of ER&#945; and cPKC activations induced by E17G, demonstrated that ICI did not affect cPKC activation whereas Gö6976 prevented that of ER&#945;, indicating that cPKC activation precedes that of ER&#945;. Conclusion: ER&#945; is involved in the biliary secretory failure induced by E17G and its activation follows that of cPKC.  ","palabras_clave":"colestasis|estrogenos|Bsep|Mrp2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88470,"idioma_id":4,"titulo":"First Development, Characterization and Experimental Validation of sunflower (Helianthus annuus L.) gene expression oligo microarray","resumen":"Oligonucleotide-based microarrays with accurate gene coverage represent a key strategy for transcriptional studies in orphan species such as sunflower, H. annuus L., which lacks full genome sequences. The goal of this study was the development and functional annotation of a comprehensive sunflower unigene collection and the design and validation of a custom sunflower oligonucleotide-based microarray. A large scale EST (>130,000 ESTs) curation, assembly and sequence annotation was performed using Blast2GO (www.blast2go.de). The EST assembly comprises 41,013 putative transcripts (12,924 contigs and 28,089 singletons). The resulting Sunflower Unigen Resource (SUR version 1.0) was used to design an oligonucleotide-based Agilent microarray for cultivated sunflower. This microarray includes a total of 42,326 features: 1,417 Agilent controls, 74 control probes for sunflower replicated 10 times (740 controls) and 40,169 different non-control probes. Microarray performance was validated using a model experiment examining the induction of senescence by water deficit. Pre-processing and differential expression analysis of Agilent microarrays was performed using the Bioconductor limma package. The analyses based on p-values calculated by eBayes (p<0.01) allowed the detection of 558 differentially expressed genes between water stress and control conditions; from these, ten genes were further validated by qPCR. Over-represented ontologies were identified using FatiScan in the Babelomics suite. This work generated a curated and trustable sunflower unigene collection, and a custom, validated sunflower oligonucleotide-based microarray using Agilent technology. Both the curated unigene collection and the validated oligonucleotide microarray provide key resources for sunflower genome analysis, transcriptional studies, and molecular breeding for crop improvement.","palabras_clave":"microarray|sunflower|bioinformatics|functional annotation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88471,"idioma_id":5,"titulo":"LA ZONA DE ALTERACIÓN ARROYO LA CHILCA-ZANJÓN DEL BUITRE, BLOQUE DE SAN RAFAEL, MENDOZA","resumen":"La zona de alteración Arroyo La Chilca-Zanjón del Buitre está ubicada en el bloque de San Rafael (35°24\u20198\u201D S; 68°19\u201925,8\u201D O), Mendoza. Estudios previos definieron preliminarmente que corresponde a un sistema de tipo pórfiro cuprífero vinculado genéticamente al magmatismo gondwánico. Esta área de alteración se desarrolla en una secuencia compuesta por brechas ignimbríticas e ignimbritas traquiandesíticas con intercalaciones de areniscas tobáceas y coladas andesíticas a las que intruyen cuerpos subvolcánicos andesíticos y traquiandesítico-dacíticos. La litología de la secuencia volcánica así como sus características geoquímicas confirman su correlación con la sección inferior del Ciclo Magmático Choiyoi (Pérmico inferior). El área de alteración presenta una zona potásica con una asociación compuesta por feldespato potásico-cuarzo-magnetita. A ésta se superpone alteración fílica con una asociación de cuarzo-muscovita-pirita-(rutilo) acompañada por venillas de cuarzo-pirita. Por último se reconoce una carbonatización tardía. En las proximidades de la zona de alteración afloran vetillas con mineralización de pirita-calcopirita-galena-esfalerita en ganga de cuarzo. La geoquímica de metales indica  moderadas anomalías de Ag y Au y pequeñas anomalías de Cu, Mo, Pb y Zn. El análisis estadístico permite definir la existencia de un pulso mineralizante de Cu-Mo y un segundo pulso de Mo reconocido solamente en Zanjón del Buitre. Asimismo se definen dos pulsos de Zn, uno de los cuales estaría genéticamente vinculado al Cu.","palabras_clave":"Alteración hidrotermal|Geoquímica de metales|Pórfiro cuprífero|Sección inferior Ciclo Magmático Choiyoi|Bloque de San Rafael"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88472,"idioma_id":5,"titulo":"Accidentes, decisiones y sorpresas: Un relato acerca de cómo es posible abordar las transformaciones de urbanizaciones populares en el Área Metropolitana de Buenos Aires","resumen":"El objetivo de este artículo es presentar la trastienda de una investigación que se propuso describir y comprender cómo se han transformado las urbanizaciones de origen informal, sus viviendas y sus habitantes, en el Área Metropolitana de Buenos Aires. Esta investigación se inserta en el marco de un estudio multicéntrico, del que forman parte diferentes ciudades de América Latina, bajo el proyecto: \u201CThe rehabilitation of consolidated irregular settlements in Latin American Cities: Towards a \u2018third generation\u2019 of public policy analysis and development\u201D, desarrollado por la Latin American Housing Network, Universidad de Texas (Austin). Aquí presentamos la estrategia metodológica adoptada, las técnicas y los pasos definidos para abordar nuestro objeto de estudio a nivel local y su articulación con un proyecto de carácter colectivo que involucra no sólo investigadores de distintas ciudades sino también de diferentes disciplinas. Nuestro propósito es mostrar la realidad  de este proceso investigativo, con sus accidentes e imprevistos y las decisiones adoptadas para superarlos.","palabras_clave":"Villas|Asentamientos|Transformaciones territoriales|Estrategia metodológica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88473,"idioma_id":5,"titulo":"Estrategias de acceso al suelo y a la vivienda en barrios populares del Área Metropolitana de Buenos Aires","resumen":"En este trabajo se investiga la producción social de los asentamientos y barrios populares ubicados en el Área Metropolitana de Buenos Aires. Describe los procesos de integración, la urbanización y la consolidación de los distritos e investiga las trayectorias familiares y estrategias de acceso a la tierra y a la vivienda. Busca también las conexiones entre dos escalas geográficas de análisis: por un lado, los cambios en el barrio y en el lote y, por otro, los cambios en la vivienda. El estudio se realizó en cuatro distritos de la región metropolitana. La investigación de los procesos de producción de hábitat se basó en una encuesta realizada en 2008, y la selección de casos de estudio en profundidad se hizo de acuerdo con los criterios de significación adoptados.","palabras_clave":"Producción del Hábitat|Políticas de Regularización|Acceso al suelo urbano|Hábitat popular"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88474,"idioma_id":4,"titulo":"Assessment of Trace Metal Concentrations in Feathers of White-chinned Petrels, Procellaria aequinoctialis, from the Patagonian Shelf","resumen":"Cd, Cr, Cu, Fe, Ni, Pb, and Zn were measured infeathers from male and female White-chinned petrels Procelllaria aequinoctialisaccidentally killed in longliners off Argentina in 2005. Cd, Pb, and Ni concentrations in adultfeathers were below detection limits regardless of the birds\u2019sex. Metal concentrations did not vary with sex for Cu, Fe and Zn in feathersof adult birds despite significant differences in body size between males andfemales. The Cu and Fe concentrations differed significantly between the type offeather within individual birds. The mean concentrations of metals determined herewere within the range of concentrations reported in feather tissues of otherrelated Procellariiformes species from different biogeographic areas. However,the concentrations of Cr were similar to those reported for other petrels frompolluted areas of the North Pacific. Thus, it appears likely that levels of pollution in Patagoniamay not be as negligible as previously thought for some trace metals. ","palabras_clave":"Heavy metals|White-chinned Petrels|Pollution monitoring|Patagonian Shelf"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88475,"idioma_id":4,"titulo":"Above and belowground biomass and nutrient pools of Spartina alterniflora (smooth cordgrass) in a South American salt marsh","resumen":"In order to examine the role of the position in the tidal range on biomass production and nutrient pools of Spartina alterniflora in an Argentinian estuary, we estimated productivity, concentration of C, N and P in tissues and pools (concentration x biomass) of these elements in low (LM) and high (HM) zones. Aboveground biomass of S. alterniflora was higher in HM than in LM. Aboveground primary productivity was 106 and 439 g dry wt. m-2 yr-1 in LM and HM, respectively. Belowground biomass was similar in LM and HM. Belowground primary productivity was 526 and 744 g dry wt. m-2 yr-1 for LM and HM, respectively. Nutrient pools were higher in HM than in LM. Biomass and productivity values were low, which makes nutrient pools low. The lower values of the parameters analysed in LM than in HM indicate that position in the tidal range is an important factor in this system, possibly due to the effect of flooding. Moreover, this pattern is opposite to the general one observed in the north hemisphere, meaning that studying marshes from different environments is worth-doing. Since pools were higher in HM, this zone would be more important for nutrient input to the estuary.           ","palabras_clave":"Spartina alterniflora|biomass|primary productivity|nutrient pools"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88476,"idioma_id":4,"titulo":"On the centralizers in the Weyl algebra","resumen":"Let P,Q be elements of the Weyl algebra W. We prove that if [Q,P]=1, then the centralizer of P is the polynomial algebra k[P].","palabras_clave":"Weyl algebra|Centralizers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88477,"idioma_id":4,"titulo":"Non commutative truncated polynomial extensions","resumen":"We introduce the notion of non commutative truncated polynomial  extension of an algebra A. We study two families of these extensions.  For the first one we obtain a complete classication and for the second one,  which we call upper triangular, we find that the obstructions to inductively construct them, lie in the Hochschild homology of A, with coecients in a suitable A-bimodule.","palabras_clave":"Twisting maps|Polynomial rings"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88478,"idioma_id":4,"titulo":"Cyclic homology of Brzezinski's crossed products and of braided Hopf crossed products","resumen":"Let k be a field, A a unitary associative k-algebra and V a k-vector space endowed with a distinguished element 1_V . We obtain a mixed complex, simpler than the canonical one, that gives the Hochschild, cyclic, negative and periodic homologies of a crossed product E := A# f V, in the sense of Brzezi´nski.We actually work in the more general context of relative cyclic homology. Specifically, we consider a subalgebra K of A that satisfies suitable hypothesis and we find a mixed complex computing the Hochschild, cyclic, negative and periodic homologies of E relative to K. Then, when E is a cleft braided Hopf crossed product, we obtain a simpler mixed complex, that also gives the Hochschild, cyclic, negative and periodic homologies of E.","palabras_clave":"Crossed products|Hochschild (co)homology|Cyclic homology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88479,"idioma_id":4,"titulo":"Effect of the potential on the electrochemically induced ageing of polyaniline films","resumen":"The electrochemically induced ageing of Polyaniline films, as a function of the ageing potential, was investigated employing films of different thicknesses in3.7 M H2SO4&nbsp; solutions. The ageing process was monitored by the change of the voltammetric response in a subsequent positive going potential scan after the ageing. It is observed that the ageing process, at more positive potentials, involves increasing amounts of non reduced polymer. Also, it is observed that the rate of ageing decreases as the ageing potential increases. The changes in the voltammetric response after ageing is interpreted through a model for the voltammetric response, previously developed, that includes capacitive currents and interactions between the redox centers. The analysis shows that neither the capacitive parameters nor the total faradaic charge change during the ageing. On the other hand, only the interaction energy between the reduced centers change during the ageing. This fact leads to a narrowing of the formal redox potential distribution that can be characterized by the apparent number of exchanged electrons. The decrease of the interaction energy, between reduced centers is consistent with the reduction of the free energy of the polymer during the ageing. The kinetics of ageing is analyzed through an Elovich type of equation from which k0, the pseudo&nbsp; zero order rate constant, and b, a parameter that indicates how fast the activation free energy changes with the extent of the process, can be obtained. ","palabras_clave":"electrochemically induced ageing|polyaniline|voltammetry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88480,"idioma_id":4,"titulo":"Electrochemically induced ageing of polyaniline. An electrochemical impedance  spectroscopy study","resumen":"In this work it is shown that the impedance response of polyaniline changes with&nbsp; time,&nbsp; during&nbsp; the&nbsp; electrochemically&nbsp; induced&nbsp; ageing.&nbsp; The&nbsp; results&nbsp; are&nbsp; analysed&nbsp; in terms&nbsp; of&nbsp; a&nbsp; simple&nbsp; equivalent&nbsp; circuit&nbsp; which&nbsp; parameters&nbsp; change&nbsp; linearly&nbsp; with&nbsp; the logarithm of the ageing time. As proposed earlier, this dependence can be explained by considering that the ageing kinetics is of the Roginskii-Zeldovich or Elovich type. It is proposed that the changes in the impedance response could be associated to the decrease of the electrochemically active area of the polymer\/electrolyte interface. &nbsp;","palabras_clave":"Polyaniline|Conducting polymers|EIS |impedance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88481,"idioma_id":4,"titulo":"Nanocrystalline ZnO photoconductivity measurements","resumen":"Pure ZnO have been prepared on amorphous SiO2 substrates from a precursor solution of dihydrated zinc acetate andabsolute alcohol. The sol was deposited on the substrates by the spin-coating technique. After de deposit of each layer, adrying treatment was performed at 200 ºC for10 min, to solidify the deposited material. Finally, all the specimens werethermally treated at 450 ºC for 3 h to crystallize them. The characterization by X rays diffraction was performed using theglancing angle configuration and films morphology was observed with an Atomic Force Microscope and by FieldEmission Scanning Electron Microscopy. Photoconductivity was studied in function of the wavelength at 50 ºC using thefour-points method and illuminating by arrays of LEDs with different wavelengths.","palabras_clave":"ZnO nanocristalino"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88482,"idioma_id":4,"titulo":"UPDATING QUALITY MODELS FOR EVALUATING NEW GENERATION WEB APPLICATIONS","resumen":"Web applications (WebApps) and their quality specification and evaluation have been the subject of abundant research. However, the particular features of new generation WebApps pose new challenges regarding current quality models and their included characteristics and sub-Characteristics. For instance, functional added value (e.g. integratedness and beneficialness), learnability in use, communicability,  sense of community and, ultimately, user experience are characteristics very often neglected in quality modeling or placed appropriately in quality views. Considering the recently issued ISO 25010\/25012  standards and quality models for WebApps, in this work we propose updating our previously developed quality models and framework so-called 2Q2U (Quality, Quality in use, actual Usability and User experience) in the light of those features of new generation WebApps. The resulting quality models and framework in conjunction with evaluation strategies contribute towards a flexible, integrated approach to measure and evaluate different eras of WebApps. In order to illustrate the approach a practical case for evaluating a mashup WebApp is conducted.","palabras_clave":"QUALITY MODELS|QUALITY IN USE|ACTUAL USABILITY|USER EXPERIENCE|FUNCTIONAL QUALITY|INFORMATION QUALITY|EVALUATION APPROACH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88483,"idioma_id":4,"titulo":"Obesity programmed mice are rescued by early genetic intervention.","resumen":"Obesity is a chronic metabolic disorder affecting half a billion people worldwide. Major difficulties in managing obesity are the cessation of continued weight loss in patients after an initial period of responsiveness and rebound to pretreatment weight. It is conceivable that chronic weight gain unrelated to physiological needs induces an allostatic regulatory state that defends a supranormal adipose mass despite its maladaptive consequences. To challenge this hypothesis, we generated a reversible genetic mouse model of early-onset hyperphagia and severe obesity by selectively blocking the expression of the proopiomelanocortin gene (Pomc) in hypothalamic neurons. Eutopic reactivation of central POMC transmission at different stages of overweight progression normalized or greatly reduced food intake in these obesity-programmed mice. Hypothalamic Pomc rescue also attenuated comorbidities such as hyperglycemia, hyperinsulinemia, and hepatic steatosis and normalized locomotor activity. However, effectiveness of treatment to normalize body weight and adiposity declined progressively as the level of obesity at the time of Pomc induction increased. Thus, our study using a novel reversible monogenic obesity model reveals the critical importance of early intervention for the prevention of subsequent allostatic overload that auto-perpetuates obesity.","palabras_clave":"OBESITY|PROOPIOMELANOCORTIN|FOOD INTAKE|MUTANT MOUSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88484,"idioma_id":4,"titulo":"Role of thymulin on the somatotropic axis in vivo","resumen":"AIMS: There is clear evidence for the existence of a bi-directional thymus-somatotropic axis and several studies suggest that the thymic peptide thymulin may be involved in this communication. We undertook to assess the impact of serum thymulin immunoneutralization in C57BL\/6 mice and that of neonatal thymulin gene therapy (NTGT) in nude mice on body weight (BW) gain and on the histomorphometric profile of the somatotrope population. MAIN METHODS: Immunoneutralization of thymulin was done from postnatal day 1 to 35 by i.p. injections of rabbit anti-thymulin serum (á-FTS) and normal rabbit serum (NRS) in controls. NTGT was implemented in nudes using an adenoviral vectorexpressing a synthetic gene for thymulin (RAd-FTS). On postnatal day 1, heterozygous (nu\/+) and homozygous (nu\/nu) pups received a single bilateral i.m. injection either RAd-FTS or RAd-GFP (a control vector expressing greenfluorescent protein). BW gain was recorded and at the end of the study the pituitaries were immunostained for growth hormone (GH). Serum GH and thymulin were determined by radioimmunoassay and bioassay, respectively. KEY FINDINGS: Thymulin immunoneutralization induced a significant decrease in BW gain, serum GH and somatotrope cell density as well as an increase in somatotrope cell size. NTGT markedly increased BW gain, serum thymulin (P&lt;0.01) andsomatotrope cell and volume density in nu\/nu mice. SIGNIFICANCE: Our results suggest that thymulin plays a relevant physiological role on the thymus-somatotropic axis in mice.","palabras_clave":"THYMUS-SOMATOTROPIC|THYMULIN GENE THERAPY|RAD-FTS|THYMULIN IMMUNONEUTRALIZATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88485,"idioma_id":4,"titulo":"Distinctive Epstein-Barr virus variants associated with benign and malignant pediatric pathologies: LMP1 sequence characterization and linkage with other viral gene polymorphisms","resumen":"The ubiquitous Epstein-Barr virus (EBV) is related to the development of lymphomas and is also the etiological agent for infectious mononucleosis (IM). Sequence variations in the LMP1 encoding gene have been deeply studied in different pathologies and geographic regions. Controversial results propose the existence of tumor-related variants while others argued in favor of a geographical distribution of these variants. However, current reports assessing EBV variants in IM were performed in adult patients who display multiple variant infections. In the present study, LMP1 variants in 15 pediatric patients with IM and 20 pediatric EBV-associated lymphomas from Argentina were compared as representatives of benign and malignant infection in children, respectively. A three months follow-up study of LMP1 variants in peripheral blood cells and in oral secretions of patients with IM was performed. Moreover, an integrated linkage analysis was performed with variants of EBNA1 and the promoter region of BZLF1. Similar sequence polymorphisms were detected in both pathological conditions, IM and lymphoma, but these differ from those previously described in healthy donors from Argentina and Brazil. The results suggest that certain LMP1 polymorphisms, namely the 30bp deletion and high copy number of the 33bp repeats, could be associated to EBV-related pathologies, either benign or malignant instead of just tumor related. Additionally, this is the first study to describe the Alaskan variant in EBV-related lymphomas previously restricted to nasopharyngeal carcinomas from North America.","palabras_clave":"LMP1|Infectious Mononucleosis|Lymphoma|Pediatric Patients"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88486,"idioma_id":4,"titulo":"The role of innate cells is coupled to a Th1-polarized immune response in pediatric Nonalcoholic Steatohepatitis","resumen":"Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease influenced by risk  factors for the metabolic syndrome (MetS). In adult patients, NASH is associated with an  altered phenotype and functionality of peripheral immune cells, the recruitment of leukocytes  and intrahepatic activation and an exacerbated production of reactive oxygen species (ROS) and  cytokines. It remains unclear if the previously described differences between pediatric and adult  non alcoholic fatty liver diseases (NAFLD) also reflect differences in their pathogenesis. We  aimed to investigate the phenotype and functionality of circulating immune cells, and the  potential contribution of liver infiltrating leukocytes to the immunological imbalance in  pediatric NASH. By a real-time PCR based analysis of cytokines and immunohistochemical  staining of liver biopsies we demonstrated that the hepatic microenvironment is dominated by  interferon-gamma (IFN-&#61543;) but not interleukin (IL) 4 and is infiltrated by a higher number of  CD8+ cells in pediatric NASH. The number of infiltrating neutrophils positively correlated with  ROS generation by peripheral polimorphonuclear (PMN) cells. By a flow cytometric analysis of  peripheral blood lymphocytes (PBL) a distinctive increase in CD8+ CD45RO and CD8+  CD45RA subpopulations and an increased production of IFN-&#947; by CD4 and CD8 positive cells  was shown. The production of ROS following PMA stimulation was augmented in circulating  neutrophils but not in monocytes. In sum, the distinctive phenotype and functionality of  infiltrating and circulating cells suggest that the role of innate cells is coupled to a Th1-  polarized immune response in pediatric NASH.","palabras_clave":"memory and naïve T cell subsets|polymorphonuclear cells|oxidative stress|Th1\/Th2 cytokines|pediatric NASH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88487,"idioma_id":4,"titulo":"The chlorotic symptom induced by Sunflower chlorotic mottle virus is associated with changes in redox-related gene expression and metabolites","resumen":"Systemic infections are commonly associated with changes in host   metabolism and gene expression.  Sunflower chlorotic mottle virus   (SuCMoV) causes systemic infection with sugar increase, photoinhibition    and increase in antioxidant enzyme activities before chlorotic symptom   appearance in sunflower leaves.  The aim of this study was to determine   if chlorotic symptom development induced by SuCMoV infection  is   accompanied by changes in different redox-related metabolites and   transcripts. Symptom development  was analyzed in the second pair of   leaves (systemic infection) at different post-inoculation times:  before   symptom appearance (BS, 4 dpi), and at an early (ES, 7 dpi) and later   stage (LS, 12 dpi) of symptom  expression. The results showed that the   virus reaches the second pair of leaves at 4 dpi. A positive correlation    between chlorotic symptom and number of viral copies was also   observed. Changes in hydrogen  peroxide, glutathione, pyridine   nucleotides and ATP content were observed since symptom appearance  (ES,   7 dpi). The expression of some of the genes analyzed was also strongly   affected by SuCMoV infection.  Specifically, down-regulation of both   chloroplast-encoded genes and chloroplast-targeted genes:  psbA, rbcS,   Cu\/Zn sod, Fe sod, phosphoglycolate phosphatase, psbO, psaH and fnr was   present, whereas the  expression of cytoplasmic-targeted genes, apx1,   and Cu\/Zn sod was up-regulated. Mitochondrial Mn sod  decreased at BS   stage and aox decreased only at ES stage. Peroxisomal catalase (cat-2)   was lower at BS and  LS stages. All these results suggest that SuCMoV   infection induces progressive changes in determinants  of redox   homeostasis associated with chlorotic symptom development.","palabras_clave":"Gene expression|Redox state|Symptom development|Sunflower"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88488,"idioma_id":4,"titulo":"Research advances in plant-made flavivirus antigens","resumen":"Outbreaks of flaviviruses such as dengue (DV), yellow fever (YFV), Japanese encephalitis (JEV), tick-borne encephalitis (TBEV) and West Nile (WNV) affect numerous countries around the world. The fast spread of these viruses is the result of increases in the human population, rapid urbanisation and globalisation. While vector control is an important preventive measure against vector-borne diseases, it has failed to prevent the spread ofthese diseases, particularly in developing countries where the implementation of control measures is intermittent. As antiviral drugs against flaviviruses are not yet available, vaccination remains the most important tool for prevention. Although human vaccines for YFV, TBEV and JEV are available, on-going vaccination efforts are insufficient to prevent infection. No vaccines against DENV and WNV are available. Research advances have provided important tools for flavivirus vaccine development, such as the use of plants as a recombinant antigen production platform. This review summarises the research efforts in this area and highlights why a plant system is considered a necessary alternative production platform for high-tech subunit vaccines.","palabras_clave":"FLAVIVIRUS|RECOMBINANT PROTEIN|MOLECULAR FARMING|ANTIGENS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88489,"idioma_id":4,"titulo":"Isolation and characterization of a Rhodococcus strain with phenol degrading ability and its potential use for tannery effluent biotreatment","resumen":"AbstractIntroduction Wastewater derived from leather productionmay contain phenols, which are highly toxic, and theirdegradation could be possible through bioremediationtechnologies.Materials, methods and results In the present work, micro-bial degradation of phenol was studied using a tolerantbacterial strain, named CS1, isolated from tannery sedi-ments. This strain was able to survive in the presence ofphenol at concentrations of up to 1,000 mg\/L. On thebasis of morphological and biochemical properties, 16SrRNA gene sequencing, and phylogenetic analysis, theisolated strain was identified as Rhodococcus sp. Phenolremoval was evaluated at a lab-scale in Erlenmeyerflasks and at a bioreactor scale in a stirred tank reactor.Rhodococcus sp. CS1 was able to completely removephenol in a range of 200 to 1,000 mg\/L in mineralmedium at 30 ± 2 °C and pH 7 as optimal conditions.In the stirred tank bioreactor, we studied the effect ofsome parameters, such as agitation (200?600 rpm) andaeration (1?3 vvm), on growth and phenol removalefficiency. Faster phenol biodegradation was obtained inthe bioreactor than in Erlenmeyer flasks, and maximumphenol removal was achieved at 400 rpm and 1 vvm inonly12h.Furthermore, Rhodococcus sp. CS1 strain wasable to grow and completely degrade phenols from tan-nery effluents after 9 h of incubation.Conclusion Based on these results, Rhodococcus sp. CS1could be an appropriate microorganism for bioremediationof tannery effluents or other phenol-containing wastewaters.","palabras_clave":"PHENOL REMOVAL|BIOREMEDIATION|PHENOL TOLERANCE|CATECHOL 1,2-DIOXYGENASE|TANNERY EFFLUENTS|BIOREACTOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88490,"idioma_id":4,"titulo":"Endotoxemia impairs heart mitochondrial function by decreasing electron transfer, ATP synthesis and ATP content without affecting membrane potential","resumen":"Acute endotoxemia (LPS, 10 mg\/kg ip, Sprague  Dawley rats, 45 days old, 180 g) decreased the O2 consumption  of rat heart (1 mm3 tissue cubes) by 33% (from 4.69 to  3.11 &#956;mol O2\/min. g tissue). Mitochondrial O2 consumption  and complex I activity were also decreased by 27% and  29%, respectively. Impaired respiration was associated to  decreased ATP synthesis (from 417 to 168 nmol\/min. mg  protein) and ATP content (from 5.40 to 4.18 nmol ATP\/mg  protein), without affecting mitochondrial membrane potential.  This scenario is accompanied by an increased production  of O2&#9679;&#8722; and H2O2 due to complex I inhibition. The  increased NO production, as shown by 38% increased  mtNOS biochemical activity and 31% increased mtNOS  functional activity, is expected to fuel an increased ONOO&#8722;  generation that is considered relevant in terms of the biochemical  mechanism. Heart mitochondrial bioenergetic dysfunction  with decreased O2 uptake, ATP production and  contents may indicate that preservation of mitochondrial  function will prevent heart failure in endotoxemia.","palabras_clave":"ENDOTOXEMIA|REACTIVE OXYGEN SPECIES|NITRIC OXIDE|MITOCHONDRIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88491,"idioma_id":4,"titulo":"Functionalized Bridged Silsesquioxane-based Nanostructured Microspheres: Performance as Novel Drug-delivery Devices in Bone Tissue-related Applications","resumen":"Two kinds of functionalized nanostructured hybrid microspheres, based on the bridged silsesquioxane family, were synthesized by employing the sol-gel method via self-assembling of two different organic-inorganic bridged monomers. The architecture reached at molecular level allowed incorporating acetylsalicylic acid (ASA) as anti-inflammatory model drug. The ASA-functionalized microspheres were characterized as delivery devices in simulated body fluid (SBF). The release behaviors of the synthesized microspheres (Fickian or anomalous diffusion mechanisms) were shown to be dependent on the chemical nature of the bridged monomers employed to synthesize the hybrid materials. The functionalized microspheres were proposed as delivery systems into calcium phosphate cements (CPCs), in order to slow down the characteristic drug-delivery kinetics of this kind of bone tissue-related materials. The incorporation of the new functionalized microparticles into the CPCs represented a viable methodology to modify the ASA-release kinetics in comparison to a conventional CPC containing the drug dispersed into the solid phase. The ASA-delivery profiles obtained from the microspheres-loaded CPCs showed that 40-60% of drug can be released after 2 weeks testing in SBF. The inclusion of the microspheres into the CPC matrices allowed modifying the release profiles through a mechanism that involved two stages: (1) the diffusion of the drug through the organic-inorganic matrix of the microspheres (according to a Fickian or anomalous diffusion, depending on the nanostructuring) and, (2) the subsequent diffusion of the drug through the ceramic matrix of the hardened cements. The release behavior of the composite cements was shown to be dependent on the nanostructuring of the hybrid microspheres, which can be selectively tailored by choosing the desired chemical structure of the bridged precursors employed in the sol-gel synthesis. The obtained results demonstrated the ability of this new class of functionalized hybrid microdevices as delivery systems into calcium phosphate materials with potential bone tissue-related drug-delivery applications.  ","palabras_clave":"drug-delivery|hybrid materials|calcium phosphate cements|composite biomaterials"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88492,"idioma_id":4,"titulo":"Spectroscopic Characterization of an Oxovanadium(IV) Complex of Oxodiacetic Acid and \/o\/-Phenanthroline. Bioactivity on Osteoblast-Like Cells in Culture","resumen":"Abstract The oxovanadium(IV) complex of oxodiacetic acid (H2oda) and o-phenanthroline of stoichiometry [VO(ODA)(ophen)]×1.5H2O, which presents the&nbsp; interesting tridentate OOO coordination, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast cell lines in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. ","palabras_clave":"oxovanadium(IV)|oxodiacetic acid|o-phenanthroline|vibrational and electronic spectra|cells in culture"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88494,"idioma_id":5,"titulo":"Impactos de la transformación agropecuaria sobre la biodiversidad en la provincia de Buenos Aires","resumen":"La práctica agropecuaria trae aparejada profundas transformaciones sobre los sistemas naturales. Análogamente a lo ocurrido en otras regiones, la implantación de agroecosistemas en la pampa bonaerense ha modificado sustancialmente su estructura y funcionamiento, con los consecuentes cambios que ello implica para la biodiversidad regional. En este trabajo sintetizamos los principales impactos sobre la biodiversidad ocurridos en las últimas 2-3 décadas en la provincia de Buenos Aires detectados por nuestro grupo de trabajo, a saber: 1) la agriculturización ha derivado en cambios detectables en la abundancia y distribución de numerosas especies de vertebrados,particularmente, en retracciones de aves y mamíferos asociadas a pastizales, lo cual destaca la necesidad de mantener paisajes bajo uso ganadero con amplias áreas de pastizales, dado que varias especies amenazadas se encuentran exclusivamente en este tipo de paisaje, 2) en paisajes agrícolas altamente fragmentados, el mantenimiento de la vegetación espontánea a lo largo de banquinas, terraplenes y alambradas se presenta como una alternativa que contribuye a retener una fracción significativa de la vida silvestre en los agroecosistemas, 3) la coexistencia entre venados de las pampas (Ozotoceros bezoarticus) y ganado vacuno sólo es posible bajo sistemas de pastoreo rotativo y\/o bajo esquemas de baja carga ganadera y 4) la presencia de arboledas es un factor limitante de la abundancia de aves plagas (torcazas, palomas, cotorras) en la provincia de Buenos Aires, lo cual plantea la posibilidad de realizar un manejo adecuado de dichas especies dependiendo de la densidad y del tipo de arboledas que se planten.","palabras_clave":"PAMPA|ARGENTINA|NEOTRÓPICO|AVES DE PASTIZAL|CONSERVACIÓN DE LA BIODIVERSIDAD|MANEJO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88495,"idioma_id":4,"titulo":"-\tRenal actions of atrial natriuretic peptide in spontaneously hypertensive rats: the role of nitric oxide as a key mediator.","resumen":"Atrial natriuretic peptide (ANP) is an important regulator of blood pressure (BP). One of the mechanisms whereby ANP impacts BP is by stimulation of nitric oxide (NO) production in different tissues involved in BP control. We hypothesized that ANP-stimulated NO is impaired in the kidneys of spontaneously hypertensive rats (SHR) and this contributes to the development and\/or maintenance of high levels of BP. We investigated the effects of ANP on the NO system in SHR, studying the changes in renal nitric oxide synthase (NOS) activity and expression in response to peptide infusion, the signaling pathways implicated in the signaling cascade that activates NOS, and identifying the natriuretic peptide receptors (NPR), guanylyl cyclase receptors (NPR-A and NPR-B) and\/or NPR-C, and NOS isoforms involved. In vivo, SHR and Wistar-Kyoto rats (WKY) were infused with saline (0.05 ml\/min) or ANP (0.2 &#956;g·kg(-1)·min(-1)). NOS activity and endothelial (eNOS), neuronal (nNOS), and inducible (iNOS) NOS expression were measured in the renal cortex and medulla. In vitro, ANP-induced renal NOS activity was determined in the presence of iNOS and nNOS inhibitors, NPR-A\/B blockers, guanine nucleotide-regulatory (G(i)) protein, and calmodulin inhibitors. Renal NOS activity was higher in SHR than in WKY. ANP increased NOS activity, but activation was lower in SHR than in WKY. ANP had no effect on expression of NOS isoforms. ANP-induced NOS activity was not modified by iNOS and nNOS inhibitors. NPR-A\/B blockade blunted NOS stimulation via ANP in kidney. The renal NOS response to ANP was reduced by G(i) protein and calmodulin inhibitors. We conclude that ANP interacts with NPR-C, activating Ca-calmodulin eNOS through G(i) protein. NOS activation also involves NPR-A\/B. The NOS response to ANP was diminished in kidneys of SHR. The impaired NO system response to ANP in SHR participates in the maintenance of high blood pressure.","palabras_clave":"ATRIAL NATRIURETIC PEPTIDE|NITRIC OXIDE|KIDNEY|HYPERTENSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88496,"idioma_id":5,"titulo":"PENSAR LOS DES-BORDES MEDIÁTICOS DEL CONFLICTO: LAS CIUDADES-BARRIOS COMO SÍNTOMA DE LA ACTUAL TENDENCIA URBANA DE SOCIO-SEGREGACIÓN","resumen":"El    presente trabajo tiene como objetivo describir, desde la producción   discursiva  mediática, la conflictividad asociada a diversas decisiones   urbanísticas que  tomó el estado provincial y municipal de la ciudad de   Córdoba (Argentina), en  sucesivos gobiernos durante la primera década   del siglo XXI. A partir de un  acercamiento interpretativo sobre la   implementación de un programa habitacional  llamado Mi casa, mi vida,   nos proponemos dar cuenta de otros movimientos que  implican una fuerte   intervención estatal segregacionista en vinculación con el  sector   privado sobre la trama urbana: proceso presentado desde una perspectiva a-conflictiva por uno de los medios de comunicación más importante de   la  provincia.","palabras_clave":"SOCIO-SEGREGACION URBANA|CONFLICTOS|ACTORES|MEDIOS|IDEOLOGIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88497,"idioma_id":4,"titulo":"Size dependent phase transitions in nanostructured zirconia-scandia solid solutions","resumen":"The dependences of phase stability and solid state phase transitions on the crystallite size in ZrO2-10, 12 and 14 mol% Sc2O3 nanopowders are investigated by X-ray powder diffraction using a synchrotron source (S-XPD). The average crystallite sizes lie within the range of 35 to 100 nm, approximately. At room temperature these solid solutions were previously characterised as mixtures of a cubic phase and one or two rhombohedral phases, beta and gamma, with their fractions depending on composition and average crystallite sizes. In this study, it is shown that at high temperatures these solid solutions become cubic single-phased. The size-dependent temperatures of the transitions from the rhombohedral phases to the cubic phase at high temperature are determined through the analyses of a number of S-XPD patterns. These transitions were studied on cooling and on heating, exhibiting hysteresis effects whose relevant features are size and composition dependent.","palabras_clave":"Nanomaterials|ZrO2-Sc2O3 phase diagram|Synchrotron X-ray powder diffraction|Metastable phases"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88498,"idioma_id":4,"titulo":"Measurement of the WZ production cross section and limits on anomalous triple gauge couplings in proton-proton collisions at &#8730;s = 7 TeV with the ATLAS detector","resumen":"This Letter presents a measurement of WZ production in 1.02 fb^-1 of pp collision data at sqrt(s) = 7 TeV collected by the ATLAS experiment in 2011. Doubly leptonic decay events are selected with electrons, muons and missing transverse momentum in the final state. In total 71 candidates are observed, with a background expectation of 12.1 +\/- 1.4(stat.) +4.1\/-2.0(syst) events. The total cross section for WZ production for Z gamma^* masses within the range 66 GeV to 116 GeV is determined to be sigma_WZ^tot = 20.5 +3.1\/-2.8(stat.) +1.4\/-1.3(syst.) +0.9\/-0.8(lumi.)pb, which is consistent with the Standard Model expectation of 17.3 +1.3\/-0.8 pb. Limits on anomalous triple gauge boson couplings are extracted.","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88499,"idioma_id":4,"titulo":"Jet mass and substructure of inclusive jets in &#8730;s = 7 TeV pp collisions with the ATLAS experiment","resumen":" Recent studies have highlighted the potential of jet substructure techniques to identify the hadronic decays of boosted heavy particles. These studies all rely upon the assumption that the internal substructure of jets generated by QCD radiation is well understood. In this article, this assumption is tested on an inclusive sample of jets recorded with the ATLAS detector in 2010, which corresponds to 35 pb^-1 of pp collisions delivered by the LHC at sqrt(s) = 7 TeV. In a subsample of events with single pp collisions, measurementes corrected for detector efficiency and resolution are presented with full systematic uncertainties. Jet invariant mass, kt splitting scales and n-subjettiness variables are presented for anti-kt R = 1.0 jets and Cambridge-Aachen R = 1.2 jets. Jet invariant-mass spectra for Cambridge-Aachen R = 1.2 jets after a splitting and filtering procedure are also presented. Leading-order parton-shower Monte Carlo predictions for these variables are found to be broadly in agreement with data. The dependence of mean jet mass on additional pp interactions is also explored.","palabras_clave":"ATLAS|CERN|LHC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88500,"idioma_id":4,"titulo":"Search for extra dimensions using diphoton events in 7 TeV proton-proton collisions with the ATLAS detector","resumen":" Using data recorded in 2011 with the ATLAS detector at the Large Hadron Collider, a search for evidence of extra spatial dimensions has been performed through an analysis of the diphoton final state. The analysis uses data corresponding to an integrated luminosity of 2.12 fb^-1 of sqrt(s) = 7 TeV proton-proton collisions. The diphoton invariant mass spectrum is observed to be in good agreement with the expected Standard Model background. In the large extra dimension scenario of Arkani-Hamed, Dimopoulos and Dvali, the results provide 95% CL lower limits on the fundamental Planck scale between 2.27 and 3.53 TeV, depending on the number of extra dimensions and the theoretical formalism used. The results also set 95% CL lower limits on the lightest Randall-Sundrum graviton mass of between 0.79 and 1.85 TeV, for values of the dimensionless coupling k\/\\bar{M}_{Pl} varying from 0.01 to 0.1. Combining with previously published ATLAS results from the dielectron and dimuon final states, the 95% CL lower limit on the Randall-Sundrum graviton mass for k\/\\bar{M}_{Pl} = 0.01 (0.1) is 0.80 (1.95) TeV.","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88501,"idioma_id":4,"titulo":"Search for strong gravity signatures in same-sign dimuon final states using the ATLAS detector at the LHC","resumen":"A search for microscopic black holes has been performed in a same-sign   dimuon final state using 1.3 fb^-1 of proton-proton collision data   collected with the ATLAS detector at a centre of mass energy of 7 TeV at   the CERN Large Hadron Collider. The data are found to be consistent   with the expectation from the Standard Model and the results are used to   derive exclusion contours in the context of a low scale gravity model.","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88502,"idioma_id":4,"titulo":"Searches for supersymmetry with the ATLAS detector using final states with two leptons and missing transverse momentum in &#8730; s = 7 TeV proton\u2013proton collisions","resumen":"Results of three searches are presented for the production of supersymmetric particles decaying into final states with missing transverse momentum and exactly two isolated leptons, e or mu. The analysis uses a data sample collected during the first half of 2011 that corresponds to a total integrated luminosity of 1 fb^-1 of sqrt{s} = 7 TeV proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider. Opposite-sign and same-sign dilepton events are separately studied, with no deviations from the Standard Model expectation observed. Additionally, in opposite- sign events, a search is made for an excess of same-flavour over different-flavour lepton pairs. Effective production cross sections in excess of 9.9 fb for opposite-sign events containing supersymmetric particles with missing transverse momentum greater than 250 GeV are excluded at 95% CL. For same-sign events containing supersymmetric particles with missing transverse momentum greater than 100 GeV, effective production cross sections in excess of 14.8 fb are excluded at 95% CL. The latter limit is interpreted in a simplified weak gaugino production model excluding chargino masses up to 200 GeV.","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88503,"idioma_id":4,"titulo":"TUMOR BLOOD VESSEL 'NORMALIZATION' IMPROVES THE THERAPEUTIC EFFICACY OF BORON NEUTRON CAPTURE THERAPY (BNCT) IN EXPERIMENTAL ORAL CANCER","resumen":"We previously demonstrated the efficacy of BNCT  mediated by boronophenylalanine (BPA) to treat tumors in  a hamster cheek pouch model of oral cancer with no normal  tissue radiotoxicity and moderate, albeit reversible, mucositis  in precancerous tissue around treated tumors. It is known  that boron targeting of the largest possible proportion of  tumor cells contributes to the success of BNCT and that  tumor blood vessel normalization improves drug delivery to  the tumor. Within this context, the aim of the present study  was to evaluate the effect of blood vessel normalization on the  therapeutic efficacy and potential radiotoxicity of BNCT in  the hamster cheek pouch model of oral cancer. Blood vessel  normalization was induced by two doses of thalidomide in  tumor-bearing hamsters on 2 consecutive days. All studies in  thalidomide-treated animals were performed 48 h after the  first dose of thalidomide, previously established as the  window of normalization. Biodistribution studies were  performed with BPA at a dose of 15.5 mg 10B\/kg in  thalidomide-treated (Th+) and untreated (Th?) tumorbearing  hamsters. The effect of blood vessel normalization  prior to BPA administration on the efficacy of BNCT was  assessed in in vivo BNCT studies at the RA-3 Nuclear Reactor  in tumor-bearing hamsters. Group I was treated with BPABNCT  after treatment with thalidomide (Th+ BPA-BNCT).  Group II was treated with BPA-BNCT alone (Th? BPABNCT).  Group III was treated with the beam only after  treatment with thalidomide (Th+ BO), and Group IV was  treated with the beam only (Th? BO). Groups I and II were  given the same dose of BPA (15.5 mg 10B\/kg), and all groups  (I?IV) were exposed to the same neutron fluence. Two  additional groups were treated with the beam only at a higher  dose to exacerbate mucositis in precancerous tissue and to  explore the potential direct protective effect of thalidomide  on radiation-induced mucositis in a scenario of more severe  toxicity, i.e. Group V (Th+ hdBO) and Group VI (Th? hdBO).  The animals were followed for 28 days. Biodistribution  studies revealed no statistically significant differences in gross  boron content between Th+ and Th? animals. Overall tumor  control (complete response + partial response) at 28 days  post-treatment was significantly higher for Group I (Th+  BPA-BNCT) than for Group II (Th? BPA-BNCT): 84 6 3%  compared to 67 6 5%. Pretreatment with thalidomide did  not induce statistically significant changes in overall tumor  control induced by the beam only, i.e. 15 6 5% in Group III  (Th+ BO) and 18 6 5% in Group IV (Th? BO), or in overall  tumor control induced by the high-dose beam only, i.e. 60 6  7% in Group V (Th+ hdBO) and 47 6 10% in Group VI  (Th? hdBO). BPA-BNCT alone (Group II) induced mucositis  in precancerous tissue that reached Grades 3?4 in 80% of the  animals, whereas pretreatment with thalidomide (Group I)  prevented mucositis Grades 3 and 4 completely. Beam-only  Group III (Th+ BO) exhibited only Grade 1 mucositis in  precancerous tissue, whereas 17% of the animals in beamonly  Group IV (Th? BO) reached Grade 2 mucositis. Highdose  beam-only group V (Th+ hdBO) exhibited only Grade 2  mucositis, whereas high-dose beam-only group VI (Th?  hdBO) reached Grade 3 mucositis in 83% of the animals.  In all cases mucositis in precancerous tissue was reversible.  No normal tissue radiotoxicity was observed with any of the  protocols. Pretreatment with thalidomide enhanced the  therapeutic efficacy of BNCT and reduced precancerous  tissue toxicity.","palabras_clave":"Tumor Blood Vessel Normalization|BNCT|Experimental Oral Cancer|Thalidomide|BPA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88504,"idioma_id":4,"titulo":"Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies","resumen":"Abstract. Background: Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than that of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections labeled for Factor VIII revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window at 48 h. Conclusion: The technique developed herein has made the hamster oral cancer model amenable to research on the potential benefit of vascular normalization in head and neck cancer therapy.   ","palabras_clave":"Blood vessel normalization|hamster cheek pouch oral cancer model|oral cancer|thalidomide"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88506,"idioma_id":4,"titulo":"Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells","resumen":"Acute muscle damage, myonecrosis, is one of the main characteristics of envenoming by Bothrops genus. In this in vitro study we investigated the role of a metalloproteinase (baltergin) and an acidic phospholipase A2 (Ba SPII RP4) in the cytotoxicity exhibited by Bothrops alternatus venom. Baltergin metalloproteinase purified from the venom exerted a toxic effect on C2C12 myoblast cells (CC50: 583.34 mg\/mL) which involved morphological alterations compatible with apoptosis\/anoikis. On the contrary, the most abundant PLA2 isolated from this venom did not exhibit cytotoxicity at times and doses tested. However, when myoblasts were treated with both enzymes together, synergic activity was demonstrated. Neutralization of the venom with specific antibodies (IgG anti-baltergin and IgG anti-PLA2) confirmed this synergism.","palabras_clave":"BOTHROPS VENOM|BALTERGIN|PHOSPHOLIPASE A2|MYOBLASTS|IN VITRO EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88507,"idioma_id":4,"titulo":"Glucocorticoid alternative effects on proliferating and differentiated mammary epithelium are associated to opposite regulation of cell-cycle inhibitor expression","resumen":"Glucocorticoids influence post-natal mammary gland development by sequentially controlling cell proliferation, differentiation and apoptosis. In the mammary gland, it has been demonstrated that glucocorticoid treatment inhibits epithelial apoptosis in post-lactating glands. In this study, our first goal was to identify new glucocorticoid target genes that could be involved in generating this effect, Expression profiling, by microarray analysis, revealed that expression of several cell-cycle control genes was altered by dexamethasone (DEX) treatment after lactation. Importantly, it was determined that not only the exogenous synthetic hormone, but also the endogenous glucocorticoids regulated the expression of these genes. Particularly, we found that the expression of cell cycle inhibitors p21CIP1, p18INK4c and Atm was differentially regulated by glucocorticoids through the successive stages of mammary gland development. In undifferentiated cells, DEX treatment induced their expression and reduced cell proliferation, while in differentiated cells this hormone repressed expression of those cell cycle inhibitors and promoted survival. Therefore, differentiation status determined the effect of glucocorticoids on mammary cell fate. Particularly, we have determined that p21CIP1 inhibition would mediate the activity of these hormones in differentiated mammary cells because over-expression of this protein blocked DEX-induced apoptosis protection. Together, our data suggest that the multiple roles played by glucocorticoids in mammary gland development and function might be at least partially due to the alternative roles that these hormones play on the expression of cell cycle regulators. J. Cell. Physiol. (c) 2011 Wiley-Liss, Inc.","palabras_clave":"GLUCOCORTICOIDS|MAMMARY GLAND|APOPTOSIS|CELL CYCLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88508,"idioma_id":4,"titulo":"A clinically relevant bi-cellular murine mammary tumor model as a useful tool for evaluating the effect of retinoic acid signaling on tumor progression","resumen":"&nbsp;&nbsp;&nbsp; Es enformato digital:     1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; DOI: 10.1007\/s12282-012-0342-5.&nbsp; (no lo toma el sistema)  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;   Background The effect of retinoic acid (RA) on breast        cancer progression is controversial. Our objective was to        obtain information about breast cancer progression, taking        advantage of the ER-negative murine mammary adenocarcinoma        model LM38 (LM38-LP constituted by luminal        (LEP) and myoepithelial-like cells (MEP), LM38-HP        mainly composed of spindle-shaped epithelial cells, and        LM38-D2 containing only large myoepithelial cells), and to        validate the role of the retinoic acid receptors (RARs) in each        cell-type compartment.        Materials and methods We studied the expression and        functionality of the RARs in LM38 cell lines. We analyzed        cell growth and cell cycle distribution, apoptosis, the activity        of proteases, motility properties, and expression of the        molecules involved in these pathways. We also evaluated        tumor growth and dissemination in vivo under retinoid        treatment.        Results LM38 cell lines expressed most retinoic receptor        isotypes that were functional. However, only the bi-cellular        LM38-LP cells responded to retinoids by increasing RARb2        and CRBP1 expression. The growth of LM38 cell sublines was        inhibited by retinoids, first by inducing arrest inMEP cells, then        apoptosis in LEP cells. Retinoids induced inhibitory effects on        motility, invasiveness, and activity of proteolytic enzymes,        mainly in the LM38-LP cell line. In in-vivo assays with the        LM38-LP cell line,RAtreatment impaired both primary tumor        growth and lung metastases dissemination.        Conclusion These in-vivo and in-vitro results show that        to achieve maximum effects of RA on tumor progression        both the LEP and MEP cell compartments have to be        present, suggesting that the interaction between the LEP        and MEP cells is crucial to full activation of the RARs.","palabras_clave":"mammary breast cancer|cell lineM38|retinoic acid|metastasis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88509,"idioma_id":4,"titulo":"New species of Prototilla Schuster, 1949 from Argentina and diagnoses of the genus based on male and female (Hymenoptera: Bradynobaenidae: typhoctinae: Eotillini)","resumen":"Diagnoses for the genus Prototilla Schuster, 1949 based on males and females, new generic and specific characters, anddescriptions of four new species (Prototilla nigra Torréns, Fidalgo, Roig-Alsina &amp; Brothers, sp. nov. and P. intercalataTorréns, Fidalgo, Roig-Alsina &amp; Brothers, sp. nov. based on males, and P. striata Torréns, Fidalgo, Roig-Alsina &amp;Brothers, sp. nov. and P. telteca Torréns, Fidalgo, Roig-Alsina &amp; Brothers, sp. nov. based on females) are provided.Prototilla typhoctoides (Martinez &amp; Fritz, 1974), comb. nov. is transferred from Eotilla. A comparative table between thetwo genera of the tribe Eotillini and a key to the species of Prototilla are presented.","palabras_clave":"PROTOTILLA|EOTILLA|DIAGNOSIS|KEY TO SPECIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88510,"idioma_id":4,"titulo":"Vaccination with a BCG Strain Overexpressing Ag85B Protects Cattle against Mycobacterium bovis Challenge","resumen":"Mycobacterium bovis is the causative agent of tuberculosis in cattle but also infects other animals, including humans. Previous studies in cattle have demonstrated that the protection induced by BCG is not complete. In order to improve the protection efficacy of BCG, in this study we overexpressed Ag85B in a BCG Pasteur strain, by using an expression system based on the use of an auxotrophic strain for the leucine amino acid, and complementation with leuD. We found that vaccination of cattle with BCG overexpressing Ag85B induced higher production of IL-17 and IL-4 mRNA upon purified protein derivative (PPDB) stimulation of peripheral blood mononuclear cells (PBMCs) than vaccination with BCG. Moreover, the IL-17 mRNA expression after vaccination negatively correlated with disease severity resulting from a subsequent challenge with M. bovis, suggesting that this cytokine is a potential biomarker of cattle protection against bovine tuberculosis. Importantly, vaccination with the recombinant BCG vaccine protected cattle better than the wild-type BCG Pasteur.","palabras_clave":"BCG Ag85B|Mycobacterium bovis|protection"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88511,"idioma_id":4,"titulo":"Specific detection of all members of the  Venezuelan Equine Encephalitis complex: development of a RT-Nested PCR","resumen":"Venezuelan Equine Encephalitis (VEE) complex belongs to alphavirus genus in the family Togaviridae.  Several species of this complex are pathogenic to humans. VEE infections can produce severe or mild  disease, and many cases remain undiagnosed. A specific and sensitive reverse transcriptase nested polymerase  chain reaction (RT-Nested PCR) method was developed for the detection of all VEE subtypes,  including Rio Negro Virus (RNV) (subtype VI), which circulates only in Argentina. Degenerated primers  were designed and thermal cycling parameters were standardized. This technique is suitable for rapid  and specific detection of these viruses, and may be useful for diagnosis and surveillance.","palabras_clave":"VEEV|Alphavirus|RT-Nested PCR|Arbovirus|Diagnostic|Surveillance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88512,"idioma_id":4,"titulo":"Assessment of the Immune Responses Induced in Cattle after Inoculation of a Mycobacterium bovis Strain Deleted in Two mce2 Genes","resumen":"The generation of efficient candidate vaccines against bovine tuberculosis will contribute to the control of this zoonotic disease.Rationally attenuated Mycobacterium bovis strains generated by knockout of virulence genes are promising candidate vaccines.However, to be effective, these candidate vaccines should at least maintain the immunological properties of their virulent parentalM. bovis strains. Therefore, the aim of this study was to obtain an M. bovis strain deleted in the mce2 genes and evaluate the effectof the mutation on the immunological profile elicited by the bacteria in cattle. We showed that the activation of CD4+ T cells incattle inoculated with the mutant strain was equivalent to that in animals inoculated with the parental strain. Moreover, after invitro stimulation, peripheral blood mononuclear cells from animals inoculated with the mutant produced higher levels of mRNATh-1 cytokines than the parental strain. Therefore, these results indicate that the mce2 mutant is a promising candidate vaccineagainst bovine tuberculosis.","palabras_clave":"MYCOBACTERIUM BOVIS|VACCINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88513,"idioma_id":4,"titulo":"Influence on Effectiveness of Early Treatment with Anti-TNF Therapy in Rheumatoid Arthritis","resumen":"Purpose. To evaluate the association between starting early treatment with anti-TNF and effectiveness as well as the possibility of applying therapeutic spacing in daily practice in patients with rheumatoid arthritis (RA). Methods. Observational, retrospective study conducted in two universitary hospitals in Spain. RA patients who received the first anti-TNF (adalimumab: ADA, etanercept: ETN or infliximab: IFX) during the study period (October 2006-2010) were included. Demographic data, time since diagnosis, disease activity (DAS28-ESR) and anti-TNF dosage were analyzed. Therapeutic objective was defined as DAS28","palabras_clave":"rheumatoid arthritis|anti-TNF"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88514,"idioma_id":4,"titulo":"Fuel: A Fast General Purpose Object Graph Serializer","resumen":"Since objects need to be stored and reloaded on different environments, serializing object graphs is a very  important activity. There is a plethora of serialization frameworks with different requirements and design  trade-offs. Most of them are based on recursive parsing of the object graphs, an approach which often is too slow. In addition, most of them prioritize a language-agnostic format instead of speed and language-specific object serialization. For the same reason, such serializers usually do not support features like class-shape changes, global references or executing pre and post load actions. Looking for speed, some frameworks are partially implemented at Virtual Machine (VM) level, hampering code portability and making them difficult to understand, maintain and extend.  In this paper we present Fuel, a general-purpose object serializer based on these principles: (1) speed, through a compact binary format and a pickling algorithm which invests time in serialization for obtaining  the best performance on materialization; (2) good object-oriented design, without special help at VM; (3) serialize any object, thus have a full-featured language-specific format.  We implement and validate this approach in Pharo, where we demonstrate that Fuel is faster than other serializers, even those with special VM support. The extensibility of Fuel made possible to successfully serialize various objects: classes in Newspeak, debugger stacks, and full CMS object graphs.","palabras_clave":"OBJECT-ORIENTED PROGRAMMING|SERIALIZATION|OBJECT GRAPHS|PICKLE FORMAT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88515,"idioma_id":4,"titulo":"A systematic review of applying modern software engineering techniques to developing robotic systems","resumen":"Robots have become collaborators in our daily life. While robotic systems become more and more complex, the need to engineer  their software development grows as well. The traditional approaches used in developing these software systems are reaching their  limits; currently used methodologies and tools fall short of addressing the needs of such complex software development. Separating  robotics&#8223; knowledge from short-cycled implementation technologies is essential to foster reuse and maintenance. This paper  presents a systematic review (SLR) of the current use of modern software engineering techniques for developing robotic software  systems and their actual automation level. The survey was aimed at summarizing existing evidence concerning applying such  technologies to the field of robotic systems to identify any gaps in current research to suggest areas for further investigation and  provide a background for positioning new research activities.","palabras_clave":"robotic systems|survey|software engineering"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88516,"idioma_id":4,"titulo":"Kinetic study of the partial hydrogenation of 1-heptyne on tungsten oxide supported on alumina","resumen":"Partial hydrogenation of alkynes have industrial and academic relevance on a large scale; industries such aspetrochemical, pharmacology and agrochemical use these compounds as raw material. Typical commercial catalysts contains palladium. Finding an economic, active and selective catalyst for the production of alkenes via partial hydrogenation of alkynes is thus an important challenge. On the other hand, the literature on kinetic studies of partial hydrogenation of heavy alkynes is scarce. So the main objectives of this work were to prepare a cheaper catalyst based on lowWloading, and study the kinetic of the partial hydrogenation of 1-heptyne. A pseudo-homogeneous and six heterogeneous kinetic models were analyzed. The catalyst was characterized by ICP, XPS, DRX, TPR and hydrogen chemisorption techniques. The characterization results indicate that only WOx species are present on the alumina surface. The WOx\/Al2O3 catalyst was active and selective for producing 1-heptene even at low reaction temperatures, the partial hydrogenation of 1-heptyne proceeds via two irreversible reactions in parallel.Thebest fit of the experimental data was achieved with a heterogeneous Langmuir-Hinshelwood-Hougen-Watson model in which the rate controlling step is the dissociative adsorption of hydrogen. The activation energy was estimated as EH2 =34.8 kJ mol-1.","palabras_clave":"SELECTIVE HYDROGENATION|ALKYNE|TUNGSTEN CATALYSTS|KINETIC STUDY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88517,"idioma_id":4,"titulo":"Geographical pattern and ploidy levels of the weed Solanum elaeagnifolium (Solanaceae) from Argentina","resumen":"A total of 106 samples taken from natural Argentinean populations of the weedy Solanum elaeagnifolium (subgenus Leptostemonum) were studied cytologically to understand the impact of the different ploidy levels in its distribution and origin. Classical Feulgen staining was employed to determine mitotic chromosome numbers in all samples. 2C nuclear DNA content was determined by means of PI flow cytometry in eight samples of different ploidy levels. Principal component analysis and GIS tools were employed to compare altitude, annual precipitation and annual mean temperature among accessions. Three cytotypes were found: diploid (2n = 24) which is widespread, tetraploid (2n = 48) centered in western and southern Argentina, and hexaploid (2n = 72) which predominates in central Argentina extending as well to the east. The annual precipitation is significantly different between tetraploids and hexaploids. Cx-values ranged from 1.231 to 1.275 pg, with statistical differences (of about 24.5\u201350.9 Mbp, p B 0.05) among accessions. Diploids are the most widespread cytotype and have adapted to a number of very different habitats. Tetraploids live in arid or semi-arid regions with a mean annual rainfall less than 500 mm. Hexaploids are successful in colonizing wetter areas, where no tetraploids were found. Thus, the distribution of cytotypes may be associated with habitat differences, particularly soil moisture. The observed cytotype pattern and the differences in DNA content suggest multiple places of origin for the polyploidy of S. elaeagnifolium in Argentina.","palabras_clave":"Argentina |chromosome number|distribution|DNA content"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88519,"idioma_id":4,"titulo":"High-pressure homogenization versus heat treatment: effect on survival, growth and metabolism of dairy Leuconostoc strains","resumen":"The effect of high pressure homogenization (HPH) with respect to a traditional heat treatment on the inactivation, growth at 8ºC after treatments and volatile profile of adventitious Leuconostoc strains isolated from Cremoso Argentino spoiled cheeses and ingredients used for their manufacture was evaluated. Most of Leuconostoc strains revealed elevated resistance to HPH (8 passes, 100 MPa), especially when resuspended in skim milk. Heat treatment resulted more efficient in comparison to HPH to inactivate Leuconostoc cells at the three initial levels tested. Levels of alcohols and sulfur compounds increased during incubation at 8ºC in HPH-treated samples, while highest amounts of aldehydes and ketons characterized heated samples. Leuconostoc cells resuspended in skim milk and subjected to one-single pass HPH treatments using the industrial-scale machine showed remarkable falls on viable cell counts only when 300 and 400 MPa were applied. However, cell counts of treated sample rapidly rose after only 5 days of storage at 8ºC. Leuconostoc strains tested in this work were highly resistant to inactivation treatments applied. Nor high-pressure homogenization nor heat treatment assured their total destruction, even if they were more sensitive to the thermal treatment. To enhance the inhibitory effect on Leuconostoc cells, HPH should be combined with a mild heat treatment, which besides efficient microbial inactivation, could allow maximal retention of physicochemical properties of the product.","palabras_clave":"LEUCONOSTOC|SPOILAGE BACTERIA|HIGH-PRESSURE HOMOGENIZATION|VOLATILE COMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88520,"idioma_id":4,"titulo":"Preserved fertility in a patient with a 46,XY disorder of sex development (DSD) due to a new heterozygous mutation in the NR5A1\/SF-1 gene.  Evidences of 46,XY and 46,XX gonadal dysgenesis phenotype variability in multiple members of the affected offspring","resumen":"Ver texto completo","palabras_clave":"FERTILITY|46 XY|DSD|MUTATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88521,"idioma_id":4,"titulo":"The ghost of stochastic resonance: An introductory review","resumen":"Nonlinear systems driven by noise and periodic forces with more than one frequency exhibit the phenomenon ofGhost Stochastic Resonance (GSR) found in a wide and disparate variety of fields ranging from biology togeophysics. The common novel feature is the emergence of a \u2018ghost\u2019 frequency in the system\u2019s output which is absent in the input. As reviewed here, the uncovering of this phenomenon helped to understand a range of problems, from the perception of pitch in complex sounds or visual stimuli, to the explanation of climate cycles. Recent theoretical efforts show that a simple mechanism with two ingredients are at work in all these observations. The first one is the linear interference between the periodic inputs and the second a nonlinear detection of the largest constructive interferences, involving a noisy threshold. These notes are dedicated to review the main aspects of this phenomenon, as well as its different manifestations described on a bewildering variety of systems ranging from neurons, semiconductor lasers, electronic circuits to models of glacial climate cycles.","palabras_clave":"GHOST STOCHASTIC RESONANCE|CLIMATE CYCLES|NOISE|THRESHOLD DEVICES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88522,"idioma_id":5,"titulo":"Los caminos de la música, Europa y Argentina: una iniciativa editorial a imitar","resumen":"Reseña del libro Los caminos de la música. Europa y Argentina de Pablo BARDIN, Melanie PLESCH, Pola SUÁREZ URTUBEY, Federico MONJEAU, Pablo KOHAN, Pablo GIANERA. Jujuy : EdiUnju (Editorial de la Universidad Nacional de Jujuy), 2008, 227 pp. En Revista Per Musi, Revista Acadêmica de Música, Universidad Federal de Minas Gerais, Brasil Belo Horizonte, n.25, 2012, p.117-121.","palabras_clave":"MUSICA|NACIONALISMO|RETÓRICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88523,"idioma_id":4,"titulo":"Criticality in large scale brain fMRI dynamics unveiled by a novel point process analysis","resumen":"Functional magnetic resonance imaging (fMRI) techniques have contributed   significantly to our understanding of brain function. Current methods   are based on the analysis of gradual and continuous changes in   the brain blood oxygenated level dependent (BOLD) signal. Departing from   that approach, recent work has shown that equivalent results can be   obtained by inspecting only the relatively large amplitude BOLD signal   peaks, suggesting that relevant information can be condensed in discrete   events. This idea is further explored here to demonstrate how brain   dynamics at resting state can be captured just by the timing and   location of such events, i.e., in terms of a spatiotemporal point   process. The method allows, for the first time, to define a theoretical   framework in terms of an order and control parameter derived from fMRI   data, where the dynamical regime can be interpreted as one corresponding   to a system close to the critical point of a second order phase   transition. The analysis demonstrates that the resting brain spends most   of the time near the critical point of such transition and exhibits   avalanches of activity ruled by the same dynamical and statistical   properties described previously for neuronal events at smaller scales.   Given the demonstrated functional relevance of the resting state brain   dynamics, its representation as a discrete process might facilitate   large-scale analysis of brain function both in health and disease.","palabras_clave":"fMRI|Criticality|Brain dynamics|Point Process"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88524,"idioma_id":4,"titulo":"What kind of noise is brain noise: anomalous scaling behavior of the resting brain activity fluctuations","resumen":"The study of spontaneous fluctuations of brain activity, often referred as brain noise, is getting increasing attention in functional magnetic resonance imaging (fMRI) studies. Despite important efforts, much of the statistical properties of such fluctuations remain largely unknown. This work scrutinizes these fluctuations looking at specific statistical properties which are relevant to clarify its dynamical origins. Here, three statistical features which clearly differentiate brain data from naive expectations for random processes are uncovered: First, the variance of the fMRI mean signal as a function of the number of averaged voxels remains constant across a wide range of observed clusters sizes. Second, the anomalous behavior of the variance is originated by bursts of synchronized activity across regions, regardless of their widely different sizes. Finally, the correlation length (i.e., the length at which the correlation strength between two regions vanishes) as well as mutual information diverges with the cluster´s size considered, such that arbitrarily large clusters exhibit the same collective dynamics than smaller ones. These three properties are known to be exclusive of complex systems exhibiting critical dynamics, where the spatio-temporal dynamics show these peculiar type of fluctuations. Thus, these findings are fully consistent with previous reports of brain critical dynamics, and are relevant for the interpretation of the role of fluctuations and variability in brain function in health and disease.","palabras_clave":"Brain|anomalous scaling|Criticality|networks"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88525,"idioma_id":4,"titulo":"Addenda to the insects found in birds\u2019 nests from the Neotropical Region and Neotropical immigrants in the Nearctic Region, with a discussion of the probable transmission mechanism of Ornithocoris toledoi (Hemiptera: Cimicidae)","resumen":"The present work adds some records to the insect fauna in birds\u2019 nests from the Neotropical Region and Neotropical immigrants in the Nearctic Region. Unpublished records of Triatominae (Hemiptera: Reduviidae) prior to 2005 are included here, especially the localities of some specimens from the collection of Antonio Martínez. According to new data recently published, the probable transmission mechanism of Ornithocoris toledoi (Hemiptera: Cimicidae) is presented here and discussed.","palabras_clave":"Insects|birds nests|Neotropical region|Cimicidae|transmission mechanism"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88526,"idioma_id":4,"titulo":"Effect of Clay Concentration on the Wear Behavior and Permeability of Polypropylene\/Clay Nano-composites","resumen":"The permeability and wear behavior of  nanocomposites based on polypropylene (PP), polypropylene  grafted with maleic anhydride (PPg), and montmorillonite  (MMT) have been studied. Clay concentrations of  2?15 wt % and a constant PPg:MMT ratio of 3 : 1 were  considered. The wear behavior of all materials was studied  using the ??pin-on-disc?? technique. The results indicate  that, for given clay concentration, the wear resistance  decreases with applied load and that the composites are   20 times more resistant than their matrices. Moreover,  the wear rate of the nanocomposites decreases as the clay  concentration increases while that of the corresponding  matrices increases. The PP, matrices, and composites display  similar values of friction coefficient that neither changes with  normal load. Additionally, the oxygen permeability of PP is  gradually reduced by the increase of both clay and PPg concentration,  being the effect of the filler tactoids much larger  than that of the compatibilizer.","palabras_clave":"NANOCOMPOSITES|POLYPROPYLENE|MONTMORILLONITE|WEAR|BARRIER PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88527,"idioma_id":4,"titulo":"Model Checking Propositional Deontic Temporal Logic via a mu-Calculus Characterization","resumen":"Inthispaper,wepresentacharacterizationofapropositional deontic temporal logic into &#956;-calculus. This logic has been proposed to specify and reason about fault tolerant systems, and even though is known to be decidable, no tool realizing its corresponding decision pro- cedure has been developed. A main motivation for our work is enabling for the use of model checking, for analyzing specifications in this deontic temporal logic.  We present the technical details involved in the characterization, and prove that the model checking problem on the deontic temporal logic is correctly reduced to &#956;-calculus model checking. We also show that counterexamples are preserved, which is crucial for our model checking purposes. Finally, we illustrate our approach via a case study, including the verification of some properties using a &#956;-calculus model checker.","palabras_clave":"Software Verification|Fault Tolerance|Model Checking|Temporal Logic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88528,"idioma_id":4,"titulo":"Analysis of early vigor in twenty modern cultivars of bread wheat (Triticum aestivum L.)","resumen":"        Abstract        The fast development of leaf area in seedlings is a relevant trait  in order to increase early resources acquisition. The use of semi-dwarf  genotypes in wheat has decreased the early vigor of modern cultivars. We  studied the early vigor of twenty cultivars cropped in Argentina and the main  objectives were: (i) to analyse the  genotypic variability in early vigor (ii)  to study morphological traits that can be good indicators of early vigor, such  as seed mass, leaf width and specific leaf area and (iii) to analyse if some aspects of biomass allocation in the  seedling, such as dry weight allocated to root, implicates a penalty over the  early vigor. Experiments with non-selected and selected by mass seeds were  carried out in a greenhouse. In addition, a field trial was made in order to  test the reliability of the greenhouse results. Seeds mass was the main  parameter related with early vigor. However, results from the experiment with  selected seed showed that seed mass per  se explain only partially the early vigor of the cultivars, since  significant correlation was observed between the seedling leaf area of each  cultivar in both experiments.         We observed high correlation between net assimilation rate (NAR) and  the changes in the ranking of early vigor of the cultivars throughout the  experiment. Root biomass of the seedling was positively correlated with leaf  area, indicating that both traits were not mutually exclusive.        We built simple models by multiple regressions, including some  parameters easy to be measured, in order to estimate early vigor. We found that  seed mass and width of leaves taken together showed better adjust than seed  mass or leaf width considered as unique parameter. We found significant high  correlation between early vigor of greenhouse and field experiments, thus, the  screening under semi-controlled conditions may be feasible.","palabras_clave":"EARLY  VIGOR|SPECIFIC LEAF AREA |TRITICUM AESTIVUM |WHEAT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88529,"idioma_id":4,"titulo":"Determining free energies of protein-ligand binding and association\/dissociation processes using computer simulations","resumen":"The development of new drugs is one of the most important research areas in the bio-sciences, and where structural bioinformatics   plays a central role. Over the last thirty years rational drug design has contributed to the introduction of many new drugs in the market and   computational (or in-silico based) methods are an essential part of these programs having the great advantage of the potential delivery of new   drug candidates faster and at lower cost when compared to high throughput experimental methods. At the heart of these methods, lies the   determination of a given drug (or ligand) affinity for a given protein receptor, which includes determination or knowledge of the protein-ligand   complex. Thus, the theoretical prediction of ligand binding free energies (&#916;GB), is one of the most important and yet challenging problems in   computational biochemistry, and therefore the subject of the current review. The review starts describing the so called End point methods for   computing ligand binding free energies which rely on performing MD simulations of the complexes with post-processing analysis, and shows   recent advances and improvements on &#916;GB prediction using Quantum Mechanics and explicit solvation analysis techniques. Secondly we   present free energy based methods that rely on the description of the binding process itself, reviewing first the use of biased non equilibrium   based methods for small ligand binding to metalo proteins and second the recent advances to the study and free energy determination of big   drug like ligand binding process with biased and free diffusion methods. Finally, we perform an overall comparison of the reviewed methods,   and suggest which method (or methods) should be used in different ideal cases described as examples.","palabras_clave":"FREE ENERGY|PROTEIN-LIGAND INTERACTION|MM-GBSA|MSMD|LIGAND ASSOCIATION|LIGAND DISSOCIATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88530,"idioma_id":4,"titulo":"Vortex pinning : a probe for nanoscale disorder in iron-based superconductors","resumen":"The pinning of quantized flux lines, or vortices, in th emixed state is used to quantify the effect of impurities in iron-based superconductors(IBS). Disorder at two length scales is relevant in these materials. Strong flux pinning resulting from nm-scale heterogeneity of the superconducting properties leads to the very disordered vortex ensembles observed in the IBS, and to the pronounced maximum in the critical current density jc at low magnetic fields. Disorder at the atomic scale, most likely induced by the dopant atoms, leads to ??weak collective pinning?? and a magnetic field-independent contribution jccoll. The latter allows one to estimate quasiparticle scattering rates.","palabras_clave":"Iron basedsuperconductors|Vortex pinning|Critical current|Heterogeneity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88531,"idioma_id":4,"titulo":"Components of woody plant diversity in semi-arid Chaco forests with heterogeneous land use and disturbance histories","resumen":"We assessed components of woody plant diversity within and between 16 sites dispersed across the nearly 200,000 ha of the Semi-arid Chaco vegetation of the Copo Conservation Unit, northern Argentina. Argentina\u2019s Semi-arid Chaco is an object of international conservation concern, as it is under pressure from conversion to agroindustry supplanting long-standing practices of logging and livestock grazing. We recorded from 16 (shrubby grassland following forest fire) to 27 (selectively logged forest) woody plant species per site and 37 species in total (gamma diversity). Additive partitioning showed that alpha diversity contributed 59% to gamma diversity and beta diversity only 41%. A separate additive partitioning of gamma diversity of the 13 forested sites alone showed that beta diversity attributable to logging history was considerably lower than remaining beta diversity and alpha diversity. Ordination analyses confirmed this finding: species composition of unlogged, selectively logged and intensively logged forest sites was quite similar. Results suggest that (1) woody vegetation, at least, of the Semi-arid Chaco is quite tolerant to traditional modes of land use and that (2) conservation of this vegetation as a whole must include not only \u201Cpristine\u201D sites varying in edaphic conditions but also sites varying in land use and management histories.","palabras_clave":"ADDITIVE PARTITIONING OF DIVERSITY|ALPHA DIVERSITY|BETA DIVERSITY|CHACO FOREST|GAMMA DIVERSITY|WOODY PLANT DIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88532,"idioma_id":4,"titulo":"Coastal dune vegetation of the southern Pampas (Buenos Aires, Argentina) and its value for conservation.","resumen":"Vegetation structure and species composition of southern Pampas coastal dunes were studied to evaluate their significance for conservation. The vegetation was described in 41 plots of 100&nbsp;m2 along four transects perpendicular to the coast. The floristic dataset was classified by two-way indicator species analysis. Vegetation distribution patterns were analysed in relation to the geomorphology and environmental factors. Fifty-one taxa (19 families) of vascular plants were recorded, with Asteraceae, Poaceae, and Fabaceae being the most abundant. The main vegetation groups obtained from the classification are related to distinctive geomorphology. (1) Upper beach and active dunes are habitats with extreme conditions, characterized by species-poor associations with low vegetation cover; group dominated by few shrubs and gramines like Panicum urvilleanum, Calycera crassifolia, and Senecio bergii. (2) Fixed\/semifixed dunes are habitats with more stable substrate, characterized by dense vegetation, high species richness, and woody life forms; group dominated by Poa lanuginosa, Hyalis argentea var. latisquama, Oenothera mollissima, and Glycyrrhiza astragalina. (3) Hygrophilous communities are mostly associated with dune slacks with high herbaceous vegetation cover; group largely dominated by Cortaderia selloana, Typha sp., and Imperata brasiliensis. Detrended correspondence analysis shows that the major floristic variation follows a gradient from the beach inland. Also, there is a clear zonation pattern strongly associated with geomorphologic heterogeneity. The occurrence of threatened species (e.g., Adesmia filipes, Neosparton ephedroides) and endemic taxa (S. bergii and Baccharis divaricata) plus the high habitat diversity and plant species richness confers to the area special value for conservation. The ecological role of dune vegetation is discussed in conservation and management context.","palabras_clave":"Pampas|phytosociology|psamophytic|associations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88533,"idioma_id":4,"titulo":"Analysis of three Xanthomonas axonopodis pv. citri effector proteins in pathogenicity and their interactions with host plant proteins","resumen":"Xanthomonas axonopodis pv. citri, the bacterium responsible for citrus canker, uses effector proteins secreted by a type III protein secretion system to colonize its hosts. Among the putative effector proteins identified for this bacterium, we focused on the analysis of the roles of AvrXacE1, AvrXacE2 and Xac3090 in pathogenicity and their interactions with host plant proteins. Bacterial deletion mutants in avrXacE1, avrXacE2 and xac3090 were constructed and evaluated in pathogenicity assays. The avrXacE1 and avrXacE2 mutants presented lesions with larger necrotic areas relative to the wild-type strain when infiltrated in citrus leaves. Yeast two-hybrid studies were used to identify several plant proteins likely to interact with AvrXacE1, AvrXacE2 and Xac3090. We also assessed the localization of these effector proteins fused to green fluorescent protein in the plant cell, and observed that they co-localized to the subcellular spaces in which the plant proteins with which they interacted were predicted to be confined. Our results suggest that, although AvrXacE1 localizes to the plant cell nucleus, where it interacts with transcription factors and DNA-binding proteins, AvrXacE2 appears to be involved in lesion-stimulating disease 1-mediated cell death, and Xac3090 is directed to the chloroplast where its function remains to be clarified.","palabras_clave":"Xanthomonas citri|effector proteins"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88534,"idioma_id":4,"titulo":"Toxicity of the fungicide trifloxystrobin on tadpoles and its effect  on fish\u2013tadpole interaction","resumen":"Contamination of aquatic systems is a major environmental stress that can interfere with predator?preyinteractions, altering prey or predator behavior differentially. We determined toxicity parameters of thefungicide trifloxystrobin (TFS) and examined its effects on predation rate, using a fish predator (Synbranchusmarmoratus) and four anuran tadpole species as prey (Rhinella arenarum, Physalaemus santafecinus,Leptodactylus latrans, and Elachistocleis bicolor). TFS was not equally toxic to the four tadpole species, E.bicolor being the most sensitive species, followed by P. santafecinus, R. arenarum, and L. latrans. Predationrates were evaluated using different treatments that combined predator and prey exposed or not to thisfungicide. TFS would alter the outcome of eel?tadpole interaction by reducing prey movements; thus,prey detection would decrease and therefore tadpole survival would increase. In addition, eels preyedselectively upon non-exposed tadpoles avoiding the exposed ones almost all throughout the period evaluated.Predation rate differed among prey species; such differences were not due to TFS exposure, but tointerspecific differences in behavior. The mechanism that would explain TFS-induced reduction in predationrates remains unclear; however, what is clear is that sublethal TFS concentrations have the potentialto alter prey behavior, thereby indirectly altering predator?prey interactions. In addition, we considerthat predator?prey relationships are measurable responses of toxicant exposure and provide ecologicalinsight into how contaminants modify predator?prey interactions.","palabras_clave":"tryfloxistrobin|tadpole|sensibility|prey-predator interaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88535,"idioma_id":4,"titulo":"TROMBICULID MITES (HANNEMANIA SP.) IN LEPTODACTYLUS CHAQUENSIS (AMPHIBIA: ANURA) INHABITING SELECTED SOYBEAN AND RICE AGROECOSYSTEMS OF ARGENTINA","resumen":"Trombiculid mites are known to parasitize a variety of amphibian species; however, few comparisonsof mite parasitism among sites have been made. Here, Hannemania sp. parasitism in frogs (Leptodactyluschaquensis) inhabiting agroecosystems from mideastern Argentina was described. A total of 40 adult frogs (22females and 18 males) were analyzed to detect ectoparasite Hannemania spp. larvae. Prevalence and meanabundance of Hannemania sp. were consistently higher in frogs from the agroecosystems (rice and soybean fields)than from two reference sites. Leptodactylus chaquensis might be considered an important host species ofHannemania sp., particularly in agricultural areas.","palabras_clave":"trombiculid mites|health status|frogs|agroecosystems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88536,"idioma_id":4,"titulo":"Amphibia, Anura, Hylidae, Argenteohyla siemersi pederseni (Williams and   Bosso, 1994): first record and some hematological data in Santa Fe Province, Argentina.","resumen":"We herein report on the first west-southern most record of Argenteohyla siemersi pederseni in Argentina. Thisfinding was recorded ca. 250 km far from the nearest known locality in Corrientes, and also enlarges the distribution rangefor including for the Santa Fe Province.","palabras_clave":"Argenteohyla siemersi pederseni|Santa Fe |distribution|Cayastá"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88537,"idioma_id":4,"titulo":"Geographic differences in the carapace shape of the crab Cyrtograpsus affinis (Decapoda, Varunidae) and its taxonomic implications","resumen":"Cyrtograpsus genus was traditionally considered as composed of three species: C. angulatus, C. altimanus and C. affinis. Recent works found solid evidence suggesting that C. affinis and C. altimanus belong to a single species and hypothesize that morphological differences that caused this misclassification, could be related to different ecophenotypes or life stages. Here we report a geometric morphometrics study on carapace shape of Cyrtograpsus specimens from Río de la Plata estuary (36ºS) and Nuevo gulf (42.75ºS), testing for shape differences between different sizes (allometry) and both environments. We found a statistically significant allometric shape variation and also that previous morphological descriptions of both species were associated to different sizes of a continuous allometric trajectory, concluding that C. affinis is a junior synonym of C. altimanus. Also we found significant differences in the carapace shape between different environments (estuarine vs marine), suggesting an effect of the environmental variables on carapace shape, and a potential adaptive value of this trait. ","palabras_clave":"allometry|geometric morphometrics|local adaptations|contrasting habitats"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88538,"idioma_id":5,"titulo":"Posibilidades para el mapeo de la Provincia de Entre Ríos usando la extensión de la faja Gauss-Krüger","resumen":"Este trabajo se enmarca en la necesidad de conocer la máxima escala hastadonde es posible trabajar con una sola faja Gauss Krüger dentro de los límites de laProvincia de Entre Ríos, asumiendo un nivel de error admisible bajo. Con la creaciónde la Infraestructura de Datos Espaciales de la provincia de Entre Ríos (IDEER) y laparticipación de diferentes instituciones de la región, se hace necesario arribar aacuerdos sobre los sistemas de proyección a utilizar para la presentación de la cartografíaque generan las instituciones. En el método, se aplicó el modelo matemático Gauss-Krüger para obtener los factores de escala a partir de coordenadas geodésicas y analizarlas distorsiones máximas que se producen en el territorio provincial. Los resultadosfueron 47cm\/km de distorsión máxima inherente a la proyección cartográfica dentrodel territorio provincial. Esto permite alcanzar escalas de hasta 1:5.000 para generaciónde cartografía con imágenes de alta resolución espacial.","palabras_clave":"COORDENADAS PLANAS|GAUSS-KRUGER|ENTRE RIOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88539,"idioma_id":5,"titulo":"Inserción de la industria argentina en el mercado mundial. Reflexiones sobre la posconvertibilidad","resumen":"En el marco del lanzamiento del denominado 'Plan Estratégico Industrial Argentina 2020', desde el Ministerio de Industria se ha destacado que en el marco de la posconvertibilidad el crecimiento y la diversificación de la producción industrial no sólo habría favorecido la sustitución de importaciones, sino también un incremento significativo de las exportaciones de bienes con mayor contenido tecnológico. En ese marco de supuesta reversión del proceso de desindustrialización iniciado a mediados de la década de 1970, el análisis del intercambio comercial de manufacturas debería aportar valiosos elementos de juicio para dimensionar el alcance de ciertas transformaciones a partir del colapso de la convertibilidad, y sus potencialidades y limitaciones en términos de desarrollo económico. A pesar de su relevancia, al momento existen relativamente pocos trabajos que hayan abordado particularmente la evolución del balance comercial de la industria argentina durante la etapa reciente desde un punto de vista no sólo cuantitativo sino también cualitativo. En este artículo se analiza si efectivamente el importante ritmo de crecimiento que tuvo la economía argentina en los últimos años y la mejora en sus cuentas externas han dado lugar a un extendido proceso de sustitución de importaciones y, sobre todo, a una modificación significativa del perfil de especialización industrial y de inserción del país en el mercado mundial. ","palabras_clave":"EXPORTACIONES|MANUFACTURAS|INDUSTRIA|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88540,"idioma_id":4,"titulo":"Measurements, quantum discord, and parity in spin-1 systems","resumen":"We consider the evaluation of the quantum discord and other related   measures of quantum correlations in a system formed by a spin-1 and a   complementary spin system. A characterization of general projective   measurements in such system in terms of spin averages is thereby   introduced, which allows one to easily visualize their deviation from   standard spin measurements. It is shown that the measurement optimizing   these measures corresponds in general to a nonspin measurement. The   important case of states that commute with the total Sz   spin-parity is discussed in detail, and the general stationary   measurements for such states (parity preserving measurements) are   identified. Numerical and analytical results for the quantum discord,   the geometric discord, and the one way information deficit in the   relevant case of a mixture of two aligned spin-1 states are also   presented.","palabras_clave":"quantum discord|spin systems|spin 1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88541,"idioma_id":4,"titulo":"Uncoupling cis-Acting RNA elements from coding sequences revealed a requirement of the N-terminal region of dengue virus capsid protein in virus particle formation","resumen":"Little is known about the mechanism of flavivirus genome encapsidation.   Here, functional elements of the dengue virus (DENV) capsid (C) protein   were investigated. Study of the N-terminal region of DENV C has been   limited by the presence of overlapping cis-acting RNA elements within   the protein-coding region. To dissociate these two functions, we used a   recombinant DENV RNA with a duplication of essential RNA structures   outside the C coding sequence. By the use of this system, the highly   conserved amino acids FNML, which are encoded in the RNA cyclization   sequence 5´CS, were found to be dispensable for C function. In contrast,   deletion of the N-terminal 18 amino acids of C impaired DENV particle   formation. Two clusters of basic residues (R5-K6-K7-R9 and   K17-R18-R20-R22) were identified as important. A systematic mutational   analysis indicated that a high density of positive charges, rather than   particular residues at specific positions, was necessary. Furthermore, a   differential requirement of N-terminal sequences of C for viral   particle assembly was observed in mosquito and human cells. While no   viral particles were observed in human cells with a virus lacking the   first 18 residues of C, DENV propagation was detected in mosquito cells,   although to a level about 50-fold less than that observed for a   wild-type (WT) virus. We conclude that basic residues at the N terminus   of C are necessary for efficient particle formation in mosquito cells   but that they are crucial for propagation in human cells. This is the   first report demonstrating that the N terminus of C plays a role in DENV   particle formation. In addition, our results suggest that this function   of C is differentially modulated in different host cells.","palabras_clave":"dengue virus|C protein|encapsidation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88542,"idioma_id":4,"titulo":"Anticoagulant activity of a unique sulfated pyranosic (1,3)-&#946;-L-Arabinan through direct interaction with thrombin","resumen":"A highly sulfated 3-linked &#946;-arabinan (Ab1)with arabinose in the pyranose form was obtained from green seaweed C. vermilara (Bryopsidales). It comprised major amounts of units sulfated on C-2 and C-4, and constitutes the first polysaccharide of this type isolated in the pure form and fully characterized. Ab1 showed anticoagulant activity by global coagulation tests. Less sulfated arabinans obtained from the same seaweed, have less or no activity. Ab1 exerts its activity through direct and indirect (antithrombin- and heparin cofactor II-mediated) inhibition of thrombin. Direct thrombin inhibition was studied in detail. By native PAGE it was possible to detect formation of a complex between Ab1 and human thrombin (HT). Ab1 binding to HT was measured by fluorescence spectroscopy. CD spectra of the Ab1-complex suggested that ligand binding induced a small conformational change on HT. Ab1-thrombin interactions were studied by molecular dynamic simulations using the persulfated octasaccharide as model compound. Most carbohydrate-protein contacts would occur by interaction of sulfate groups with basic amino acid residues in the surface of the enzyme, Sulfated arabinan from Codium with direct effect on thrombin being more than 60% of them performed by the exosite 2-composing residues. In these interactions the sulfate groups on C-2 showed to interact more intensely with thrombin structure. In contrast, the disulfated oligosaccharide does not promote major conformational modifications at the catalytic site when complexed to exosite 1. These results show that this novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity by a mechanism different to those found previously for other sulfated polysaccharides and glycosaminoglycans.","palabras_clave":"anticoagulants|sulfated arabinan"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88543,"idioma_id":5,"titulo":"FORMAS Y REPRESENTACIONES TARDÍAS. APROXIMACIONES A UNA MIRADA INTEGRAL AL ESTILO CERÁMICO SANAGASTA ? ANGUALASTO","resumen":"El presente trabajo tiene como objetivo brindar los resultados de una primeraaproximación al análisis morfométrico y decorativo de un conjunto de vasijas cerámicasde estilo Sanagasta-Angualasto del Período de Desarrollos Regionales (1000 ? 1480 AD)del área valliserrana. Las mismas forman parte de colecciones arqueológicas de distintasinstituciones académicas y organismos públicos del país, cuyas procedencias en sumayoría corresponden a la provincia de La Rioja, y en menor medida al norte de San Juany sur-oeste de Catamarca.Nuestra perspectiva se focaliza en comprender los criterios de análisis de forma integral,prestando especial atención a sus mutuas relaciones. De esta manera, los resultadospermiten obtener una caracterización detallada de la heterogeneidad de formas de losrecipientes cerámicos (cuencos, escudillas, jarras, ollas y tinajas), sus capacidadesvolumétricas, como también una primera individualización y discriminación de los tiposde motivos y patrones decorativos que constituyen, en conjunto con las formas, dichoestilo.","palabras_clave":"SANAGASTA-ANGUALASTO|MORFOMETRÍA |DECORACIÓN|PERÍODO DE DESARROLLOS REGIONALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88544,"idioma_id":5,"titulo":"Evangélicos y política: tensiones en torno a la libertad e igualdad religiosa en Argentina","resumen":"Los debates evangélicos actuales en torno al proyecto de una nueva ley de cultos en Argentina, propiciaron un nivel de conflictividad interno de tal magnitud que motivaron la revisión colectiva de los liderazgos establecidos, de la articulación interna de la comunidad y de los modelos públicos de la escenificación de la identidad evangélica.  Identificaremos las posiciones en pugna de los actores, sus discursos, acciones y motivaciones, a los fines de visibilizar los antagonismos construidos en torno a los debates. En las conclusiones abordaremos el nivel de incidencia de las múltiples intervenciones visitadas en la configuración del campo evangélico actual, resaltando la centralidad que adquiere la cuestión representativa en la comunidad de referencia.","palabras_clave":"EVANGÉLICOS|POLÍTICA|LIBERTAD|IGUALDAD DE CULTOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88545,"idioma_id":4,"titulo":"Attenuating the persistence of  fear memory storage using a single dose of antidepressant","resumen":"Enhanced memory for emotionally arousing events is a highly adaptive phenomenon that helps us remember both dangerous and favorable situations.1 However, under certain conditions, intrusive and persistent traumatic memories can lead to anxiety disorders, like posttraumatic stress disorder. Current therapies for anxiety disorders involve pharmacological or behavioral manipulations of long-lasting fear memories in which patients explicitly recall the painful traumatic experience. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe and less distressful manner remains unresolved.","palabras_clave":"antidepressant|behavior|rat"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88546,"idioma_id":4,"titulo":"Maintenance of long-term memory storage is dependent on late posttraining Egr-1 expression","resumen":"Expression of immediate-early genes, like Egr-1, has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is widely thought to play an important role in long-term memory (LTM) formation. However, little is known about the role of Egr-1 in the maintenance of memory storage. Here we show that dorsal hippocampal Egr-1 protein expression is upregulated between 12 and 24 h after strong inhibitory avoidance (IA) training in rats. Local infusion of antisense oligodeoxynucleotide (ASO) to specifically knockdown Egr-1 in the dorsal hippocampus 8 h posttraining impairs LTM tested 7 days, but not 1 day after training, indicating that a delayed learning-associated expression of Egr-1 is necessary for the persistence of LTM storage. In addition, we show that consolidation of the IA memory is accompanied by an increase in Egr-1 protein levels 3 h, but not immediately or 1 h after training. Local infusion of egr-1 ASO 30 min before training in the dorsal hippocampus persistently hinders memory formation measured 1 and 7 days after IA training, indicating the crucial role of Egr-1 in memory formation. Our findings demonstrate that there are at least two waves of Egr-1 expression in the dorsal hippocampus after IA training, an early wave which is involved in IA LTM formation, and a lasting late wave that peaks around 12?24 h after a strong training protocol which is specifically involved in the maintenance of LTM storage.","palabras_clave":"Persistence of LTM storage|Egr-1| Immediate-early gene|Hippocampus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88547,"idioma_id":4,"titulo":"Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells","resumen":" Abstract. Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. The objective of this study was to examine whether carnosic acid (CA), the main antioxidant compound of Rosmarinus officinalis L., would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 and LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 ìM. CA induced cell death by apoptosis in Caco-2 line after 24 h of treatment and inhibited cell adhesion and migration, possibly by reducing the activity of secreted proteases such as urokinase plasminogen activator (uPA) and metalloproteinases (MMPs). These effects may be associated through a mechanism involving the inhibition of the COX-2 pathway, because we have determined that CA downregulates the expression of COX-2 in Caco-2 cells at both the mRNA and protein levels. Therefore, CA modulates different targets involved in the development of CRC. These findings indicate that carnosic acid may have anticancer activity and may be useful as a novel chemotherapeutic agent.","palabras_clave":"Colorectal cancer |carnosic acid |COX-2|chemotherapeutic agent"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88548,"idioma_id":4,"titulo":"HIV infection and geographically bound transmission driving multidrug- and extensively-drug resistant tuberculosis in Argentina","resumen":"                  During 2003-2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed that 7 major clusters gathered 56% of patients within restricted geographic areas. The 3 largest clusters corresponded to epidemic MDR TB strains that have been undergoing transmission for &gt;10 years. The indigenous M strain accounted for 29% and 40% of MDR and XDR TB cases, respectively. Drug-resistant TB trends in Argentina are driven by spread of a few strains in hotspots where the rate of HIV infection is high. To curb transmission, the national TB program is focusing stringent interventions in these areas by strengthening infection control in large hospitals and prisons, expediting drug resistance detection, and streamlining information-sharing systems between HIV and TB programs.  ","palabras_clave":"TUBERCULOSIS|MULTIDRUG RESISTANCE|HIV|TRANSMISSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88549,"idioma_id":4,"titulo":"Clinical isolates of Mycobacterium tuberculosis differ in their ability to induce respiratory burst and apoptosis in neutrophils as a possible mechanism of immune escape","resumen":"Tuberculosis pathogenesis was earlier thought to be mainly related to the host but now it appears to be clear that bacterial factors are also involved. Genetic variability of Mycobacterium tuberculosis (Mtb) could be slight but it may lead to sharp phenotypic differences. We have previously reported that nonopsonized Mtb H37Rv induce apoptosis of polymorphonuclear neutrophils (PMNs) by a mechanism that involves the p38 pathway. Here we evaluated the capability to induce PMN apoptosis of two prevalent Mtb lineages in Argentina, the Latin America and Mediterranean (LAM), and Haarlem, using the H37Rv as a reference strain. Results showed that LAM strains strongly induced apoptosis of PMN which correlated with the induction of reactive oxygen species (ROS) production and p38 activation. Interestingly, the highly prosperous multidrug-resistant M strain, belonging to the Haarlem lineage, lacked the ability to activate and to induce PMN apoptosis as a consequence of (1) a weak ROS production and (2) the contribution of antiapoptotic mechanisms mediated at least by ERK. Although with less skill, M is able to enter the PMN so that phenotypic differences could lead PMN to be a reservoir allowing some pathogens to prevail and persist over other strains in the community.","palabras_clave":"M tuberculosis|clinical isolates|neutrophils"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88550,"idioma_id":4,"titulo":"Differential induction of macrophage cell death by antigens of a clustered and a non-clustered multidrug-resistant Mycobacterium tuberculosis strain from Haarlem family","resumen":"Some multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) genotypes are the cause of large outbreaks, including strain M identified in Argentina. In contrast, its kin strain 410 has only caused a single case to date. Cell wall antigens from Mtb were associated with the modulation of macrophage (Mac) cell death, and the ability to inhibit of M&#934; apoptosis is considered a virulence mechanism. In this study, the ability these two clinical isolates with divergent epidemiology to induce Mac cell death was evaluated using whole inactivated bacteria. We showed that gamma-irradiated (I-) strains induced M&#934; necrosis, the strongest inducer being I-410. Cell death biased towards apoptosis with the heat-killed (hk) strains, both hk-MDR strains being poorer inducers of Mac apoptosis than was H37Rv. These effects were partly due to their ability to induce anti-apoptotic mechanisms which were not related to the lack of tumor necrosis factor alpha induction or a compensatory effect of interleukin-10. The most noticeable difference between strain M and strain 410 was the ability shown by hk-M to interfere with apoptosis induced by hk-H37Rv. Thus, heat-stable and heat-labile antigens from these epidemiologically divergent Mtb strains differ in their ability to manipulate Mac death.","palabras_clave":"macrophage|cell death|M.tuberculosis|MDR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88551,"idioma_id":4,"titulo":"Robust dual reconstruction systems and fusion frames","resumen":"We study the duality of reconstruction systems, which are $g$-frames in a finite dimensional setting. These systems allow redundant linear encoding-decoding schemes implemented by the so-called dual reconstruction systems.   We are particularly interested in the projective reconstruction systems that are the analogue of fusion frames in this context. Thus, we focus on dual systems of a fixed projective system that are optimal with respect to erasures of the reconstruction system coefficients involved in the decoding process. We consider two different measures of the reconstruction error in a blind reconstruction algorithm.   We also study the projective reconstruction system that best approximate an arbitrary reconstruction system, based on some well known results in matrix theory. Finally, we present a family of examples in which the problem of existence of a dual projective system of a reconstruction system of this type is considered.","palabras_clave":"Reconstruction systems|dual reconstruction systems|erasures|fusion frames"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88552,"idioma_id":4,"titulo":"On frames for Krein spaces","resumen":"A definition of frames for Krein spaces is proposed, which extends the  notion of $J$-orthonormal basis of Krein spaces. A $J$-frame for a Krein space $(HH, K{,}{,})$ is in particular a frame for $HH$ in the Hilbert space sense. But it is also compatible with the indefinite inner product $K{,}{,}$, meaning that it determines a maximal uniformly $J$-positive and a maximal uniformly $J$-negative subspace, an analogue to the maximal dual pair associated to a $J$-orthonormal basis.     Also, each $J$-frame induces an indefinite reconstruction formula for the vectors in $HH$, which resembles the one given by a $J$-orthonormal basis.","palabras_clave":"KREIN SPACES|FRAMES|UNIFORMLY J-DEFINITE SUBSPACES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88553,"idioma_id":4,"titulo":"Studies of ciprofloxacin encapsulation on alginate\/pectin matrixes and its relationship with biodisponibility","resumen":"Screening  of Ciprofloxacin (Cip) with selected biopolymers brings about 90% antibiotic interactions  with a coacervate composed of alginate\/high metoxylated pectin in 2:1 ratio. FTIR  analysis provides information about the nature of this interaction, revealing ionic  and hydrophobic patterns among the molecules. Alginate\/high methoxylated pectin  gel microspheres developed by ionic gelation encapsulates 46.8±5.0% Cip. The gel matrix can release Cip in a sustained manner,  releasing 42.7±0.2% in 2 h under simulated stomach pH conditions, and 83.3±1.1% Cip release in 80 mM phosphate at  pH=7.40 (intestinal). The increase of sodium chloride from 50 to 200 mM implies  a Cip release from 69.0±1.5  to 95.1±3.6% respectively in 2 hour. Scanning electron microscopy revealed the  cohesive effect of HM Pectin over alginate molecules on the microsphere  surface. Those results guarantee all Cip contained in the alginate\/HM pectin  microspheres could be released in an established kinetic profile along the  gastrointestinal tract, avoiding the Cip undesirable side effects during  absorption.","palabras_clave":"Pectin .| Alginate . |Biopolymer blends . |Controlled release"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88554,"idioma_id":4,"titulo":"Influence of the Brönsted and Lewis acid sites on the catalytic activity and selectivity of Fe\/MCM-41 system","resumen":"a&nbsp; b&nbsp; s&nbsp; t&nbsp; r&nbsp; a&nbsp; c&nbsp; tThe&nbsp; system&nbsp; Fe2O3\/MCM-41,&nbsp; with&nbsp; high&nbsp; iron&nbsp; dispersion,&nbsp; was&nbsp; synthesized&nbsp; in&nbsp; order&nbsp; to&nbsp; introduce&nbsp; Lewis&nbsp; acid sites&nbsp; into&nbsp; the&nbsp; MCM-41&nbsp; structure.&nbsp; Two&nbsp; calcination&nbsp; atmospheres&nbsp; (inert&nbsp; and&nbsp; oxidant)&nbsp; were&nbsp; used&nbsp; to&nbsp; produce iron&nbsp; nanoclusters&nbsp; with&nbsp; different&nbsp; structural&nbsp; properties.&nbsp; Besides,&nbsp; a&nbsp; silylation&nbsp; treatment&nbsp; was&nbsp; realized&nbsp; on both&nbsp; solids&nbsp; with&nbsp; the&nbsp; aim&nbsp; of&nbsp; neutralizing&nbsp; the&nbsp; Brönsted&nbsp; acidity&nbsp; associated&nbsp; with&nbsp; the&nbsp; MCM-41&nbsp; silanol&nbsp; groups. The&nbsp; samples&nbsp; were&nbsp; characterized&nbsp; by&nbsp; atomic&nbsp; absorption&nbsp; spectroscopy,&nbsp; X-ray&nbsp; diffraction&nbsp; at&nbsp; low&nbsp; angles, N2 adsorption,&nbsp; temperature-programmed&nbsp; reduction,&nbsp; Fourier&nbsp; transform&nbsp; infrared&nbsp; spectroscopy,&nbsp; nuclear magnetic&nbsp; resonance&nbsp; of 29Si,&nbsp; and&nbsp; Mössbauer&nbsp; spectroscopy.&nbsp; The&nbsp; in&#64258;uence&nbsp; of&nbsp; the&nbsp; structural&nbsp; changes&nbsp; of&nbsp; the nanoclusters&nbsp; and&nbsp; the&nbsp; effect&nbsp; of&nbsp; the&nbsp; simultaneous&nbsp; presence&nbsp; of&nbsp; Lewis&nbsp; and&nbsp; Brönsted&nbsp; acid&nbsp; sites&nbsp; were&nbsp; evaluated studying&nbsp; the&nbsp; product&nbsp; distribution&nbsp; from&nbsp; the&nbsp; alpha-pinene&nbsp; oxide&nbsp; isomerization&nbsp; reaction.&nbsp; It&nbsp; was&nbsp; determined&nbsp; that the&nbsp; Brönsted&nbsp; acidity&nbsp; of&nbsp; the&nbsp; Fe\/MCM-41&nbsp; system&nbsp; has&nbsp; not&nbsp; the&nbsp; suf&#64257;cient&nbsp; acid&nbsp; strength&nbsp; to&nbsp; modify&nbsp; the&nbsp; product distribution&nbsp; which&nbsp; is&nbsp; mainly&nbsp; governed&nbsp; by&nbsp; the&nbsp; Lewis&nbsp; sites.","palabras_clave":"POX  isomerization| Lewis  acid  sites | Mössbauer  spectroscopy|MCM-41"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88555,"idioma_id":4,"titulo":"Insecticidal activity of three essential oils against two new important soybean pests: Sternechus pinguis (Fabricius) and Rhyssomatus subtilis Fiedler (Coleoptera: Curculionidae)","resumen":"AbstractIn the present study, the essential oils from Eucalyptus globulus Labill., Citrus sinensis L. Osbeck and Citrus limon L. were analysed by GC-MS (gas chromatography¨Cmass spectrometry) and evaluated for their toxic effects on Sternechus subsignatus and Rhyssomatus subtilis, two important pest of soybean in South America. Contact toxicity assayed by impregnation on filter paper discs showed that these oils caused significant mortality of the test insects (100% of mortality at 5 ¦ÌL\/cm2). Eucalyptus oil (98.9 % of 1,8-cineole) had the greatest contact toxicity (LD50 = 0.40 and 0.84 ¦ÌL\/cm2 for S. pinguis and R. subtilis, respectively), whereas orange (87.6 % of limonene) and lemon oils (62.5 and 12.6 % of limonenen and ¦Â pinene, respectively) were less toxic (LD50 &gt; 1 ¦ÌL\/cm2 for both insects). All the responses were found dose-dependent. Rhyssomatus subtilis was more resistant than Sternechus pinguis to the toxicity of the essential oils studied.Eucalyptus globulus Labill., Citrus sinensis L. Osbeck and Citrus limon L. were analysed by GC-MS (gas chromatography¨Cmass spectrometry) and evaluated for their toxic effects on Sternechus subsignatus and Rhyssomatus subtilis, two important pest of soybean in South America. Contact toxicity assayed by impregnation on filter paper discs showed that these oils caused significant mortality of the test insects (100% of mortality at 5 ¦ÌL\/cm2). Eucalyptus oil (98.9 % of 1,8-cineole) had the greatest contact toxicity (LD50 = 0.40 and 0.84 ¦ÌL\/cm2 for S. pinguis and R. subtilis, respectively), whereas orange (87.6 % of limonene) and lemon oils (62.5 and 12.6 % of limonenen and ¦Â pinene, respectively) were less toxic (LD50 &gt; 1 ¦ÌL\/cm2 for both insects). All the responses were found dose-dependent. Rhyssomatus subtilis was more resistant than Sternechus pinguis to the toxicity of the essential oils studied. ResumenEn el presente estudio se analizaron por CG-EM (cromatograf¨ªa de gases-espectrometr¨ªa de masas) los aceites esenciales de eucalipto (Eucalyptus globulus Labill.), naranja (Citrus sinensis L. Osbeck) y lim¨®n (Citrus limon L) y se evaluaron sus efectos t¨®xicos contra dos especies de plagas importantes para la soja en Sud Am¨¦rica: Sternechus subsignatus y Rhyssomatus subtilis. La toxicidad por contacto, ensayada por discos de papel de filtro impregnados, mostr¨® que estos aceites causaron una mortalidad significativa de los insectos testeados (100% de mortalidad a 5 ¦ÌL\/cm2). El aceite de eucalipto (98.9 % de 1,8-cineol) present¨® la mayor toxicidad por contacto (LD50 = 0.40 y 0.84 ¦ÌL\/cm2 para S. pinguis y R. subtilis, respectivamente), mientras que el aceite de naranja (87.6 % de limoneno) y el de lim¨®n (62.5 y 12.6 % de limoneno y ¦Â pineno, respectivamente) fueron menos t¨®xicos (LD50 &gt; 1 ¦ÌL\/cm2 para ambos insectos). Todas las respuestas fueron dosis dependiente. Rhyssomatus subtilis fue m¨¢s resistente que Sternechus pinguis a la toxicidad de los aceites esenciales estudiados.Eucalyptus globulus Labill.), naranja (Citrus sinensis L. Osbeck) y lim¨®n (Citrus limon L) y se evaluaron sus efectos t¨®xicos contra dos especies de plagas importantes para la soja en Sud Am¨¦rica: Sternechus subsignatus y Rhyssomatus subtilis. La toxicidad por contacto, ensayada por discos de papel de filtro impregnados, mostr¨® que estos aceites causaron una mortalidad significativa de los insectos testeados (100% de mortalidad a 5 ¦ÌL\/cm2). El aceite de eucalipto (98.9 % de 1,8-cineol) present¨® la mayor toxicidad por contacto (LD50 = 0.40 y 0.84 ¦ÌL\/cm2 para S. pinguis y R. subtilis, respectivamente), mientras que el aceite de naranja (87.6 % de limoneno) y el de lim¨®n (62.5 y 12.6 % de limoneno y ¦Â pineno, respectivamente) fueron menos t¨®xicos (LD50 &gt; 1 ¦ÌL\/cm2 para ambos insectos). Todas las respuestas fueron dosis dependiente. Rhyssomatus subtilis fue m¨¢s resistente que Sternechus pinguis a la toxicidad de los aceites esenciales estudiados. ","palabras_clave":"STERNECHUS SUBSIGNATUS|RHYSSOMATUS SUBTILIS|ESSENTIAL OILS|CONTACT TOXICITY|SOYA PEST"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88556,"idioma_id":4,"titulo":"Mechanisms of radical generation in the removal of phenol derivatives and pigments using different Fe-based catalytic systems","resumen":"a b s t r a c tPhenolic compounds removal is a very active research field due to occurrence and the toxicity of phenolicpollutants in industrial wastewaters. In order to make an a priori selection of the most efficient removalprocess for a target structure this contribution reviews and compares some of the mechanistic aspectsof the oxidation in the presence of hydrogen peroxide and catalyzed by complexed iron which is thein-common element in Fenton systems, plant peroxidases and biomimetics. Different substrates wereconsidered from the most basic phenol molecule to complex structures such as phenolic dyes and lignins.The reactivity of iron is related to its microenvironment generated by ligands and their electron withdrawingcapacity thus conditioning the type of cleavage induced on hydrogen peroxide and the oxidationstate change on iron upon reaction. The relative concentrations of organic to inorganic free radicals generatedcontrol the main catalytic action; i.e. from degradation up to mineralization in Fenton systems oroligomerization up to polymerization in plant peroxidases systems. Moreover, some reaction conditionsas the peroxide concentration, the initial molar ratio of organic compounds to peroxide and the type ofreaction solvent are identified as key factors to promote a desired action mechanism by peroxidases (andtheir biomimetics).","palabras_clave":"horseradish|hematin|biomimetics|dyes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88557,"idioma_id":4,"titulo":"Nd-Co substituted strontium hexaferrite powders with enhanced coercivity","resumen":"In this work we report the synthesis of Nd?Co substituted strontium hexaferrites of composition  Sr1xNdxFe11xCoxO19 by the sol?gel auto-combustion method with further heat treatment. The analysis  of the X-ray diffraction spectra shows the M-type hexagonal structure in samples treated at 1100 8C for  2 h. Coercivity increases 11% with 0.2 Nd?Co substitution, reaching a value of 68.9 A\/m (5480 Oe) while  saturation magnetization is reduced 6% to 91 A m2\/kg (91 emu\/g). The behavior of magnetic  susceptibility with an applied field shows two different maxima which are assigned to different  magnetic orderings. This assumption is supported by the appearance of two experimental values of Curie  temperatures (TC) for all the prepared samples. Magnetic susceptibility x and TC measurements suggest  an uneven distribution of the iron vacancies.","palabras_clave":"STRONTIUM|HEXAFERRITES|NEODYMIUM|MAGNETIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88558,"idioma_id":4,"titulo":"Formation of a magnetic composite by reduction of Co-Nd doped strontium hexaferrite in a hydrogen gas flow","resumen":"Co-Nd strontium hexaferrite nanoparticles synthesized by the self-combustion method were treated in a hydrogen flow at different temperatures and times.The samples were characterized structurally by  scanning electron microscopy and X-ray diffraction and magnetically with a vibrating sample  magnetometer. Phase identification showed decomposition of the hexaferrite structure into Fe3O4 and different strontium mixed oxides. The sample treated at 500ºC for 30 minutes shows good  magnetic properties due to the formation of a magnetite\/hexaferrite composite. In this case  magnetization is very close to the original sample while the coercivity slightly diminishes. The  hexagonal phase is almost completely transformed into different oxides at a reducing temperature of 500ºC for 120 minutes. The obtained results are analyzed in terms of the phase composition and of the  magnetic susceptibility of the studied samples.","palabras_clave":"STRONTIUM|HEXAFERRITE|COMPOSITE|HYDROGEN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88559,"idioma_id":4,"titulo":"Litter decomposition and nutrients dynamics in Nothofagus antarctica forests under silvopastoral use in Southern Patagonia","resumen":"The role of environmental variables on litter decomposition and its nutrient release in Nothofagus antarctica forest in Patagonia is poorly understood. Moreover, in these forests under silvopastoral use there are few antecedents. Litter decomposition and nutrient release of grasses and tree leaves were evaluated under different crown cover and two site quality stands during 480 days. Organic matter decomposition varied with crown cover for both types of litter, achieving mean values of 23 and 34% for maximal and minimal crown cover, respectively. Total transmitted radiation was the main environmental factor explaining 61 and 49% of the variation of grass and tree leaves decay rates, respectively. N, P, and Ca were mineralized during first 60 days in decomposing tree leaves and then immobilized without differences between crown cover. The K was immobilized during the evaluated period. In decomposing grass leaves the results varied according to site quality and time. There was a tendency of nutrient mineralization at the first 120 days and then immobilization. The removal of trees for silvopastoral use of N. antarctica may increase litter decomposition by changing the microclimate, but nutrients release or immobilization was mainly affected for their concentration in decomposing material.","palabras_clave":"litter decomposition|nothofagus|mineralization-immobilization|silvopastoral system"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88560,"idioma_id":4,"titulo":"Age differential response of Hyalella curvispina to a cadmium pulse: influence of sediment particle size","resumen":"In Argentina periurban streams frequently receive agricultural, livestock and industrial discharges. Heavy metals have been found in the water column and sediments of numerous water bodies of the pampean region, at levels above the limits established for aquatic life protection. This study aimed to evaluate the effect of a contaminant pulse of cadmium discharged into a water-sediment system of different particle sizes, by means of laboratory tests using juveniles and adults of Hyalella curvispina, a native amphipod. We found that the substrate particle size was a determining factor in the toxicity of cadmium and that the adults of H. curvispina were more sensitive than juveniles. We also observed a temporal difference between the two ages for the same type of sediment. Given the nature of the sediments of regional water bodies, it is expected that a discharge of cadmium, even at concentrations as low as those tested here, will affect the survival of native amphipods.","palabras_clave":"Hyalella curvispina  \t \t \t \t| Life-stage sensitivity|  Toxicity pulses | Sediment particle size"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88561,"idioma_id":4,"titulo":"Assessment of water quality in temperate-plain streams (Argentina, South America) using a multiple approach","resumen":"We assessed the water quality in two pampean lotic systems (Argentina), the Juan Blanco and Buñirigo streams, subjected to different land uses (i. e., the UNESCO Biosphere Nature Reserve versus industry and agriculture, respectively) through measurements of physicochemical data and the structural parameters of the macroinvertebrate assemblages in addition to ecotoxicological analyses. The objective was to identify the degree of ecological impairment in adversely affected areas and the consequent effects on the biota. The results obtained allowed the establishment of different water-quality classes within the study area. According to the indices applied, the downstream zone of the Buñirigo stream was categorized as moderately polluted on the basis of losses of sensitive benthic species or changes in their abundance. Likewise, acute ecotoxicological bioassays demonstrated that the water from this site had lethal effects on Caenis nemoralis (Ephemeroptera: Caenidae) larvae. This sampling point also exhibited relevant physicochemical features, such as high water conductivity and nutrient levels as well as low contents of dissolved oxygen.","palabras_clave":"POLLUTION|MACROINVERTEBRATES|PHYSICO-CHEMICAL PARAMETERS|ECOTOXICOLOGICAL ANALYSES|PAMPEAN STREAMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88562,"idioma_id":4,"titulo":"The SCR of NO with methane over In, H- and Co,In,H-ZSM-5 catalysts: The promotional effect of cobalt","resumen":"Zeolite In,H-, Co,H-, and Co,In,H-ZSM-5 were characterized by operando diffuse reflectance infraredFourier transform spectroscopy (DRIFTS), temperature-programmed reduction by hydrogen (H2-TPR),X-ray photoelectron spectroscopy (XPS), and activity in the selective catalytic reduction of NO (NO-SCR)by methane. The catalysts were shown to contain indium as [InO]+\/[InOH]2+ cations, whereas cobalt wasin the form of Co2+\/[Co-OH]+ cations or Co-oxide clusters in amounts controlled by the applied preparationmethod. The NO-SCR by methane was shown to proceed in two coupled processes on distinctlydifferent catalytic sites. One of the processes is the oxidation of NO to NO2 by oxygen over Brønsted acidsites and\/or cobalt-oxide species giving NO\/NO2 gas mixture (NO-COX reaction). The other process isthe N2 formation, which is the result of the reaction of methane and the NO\/NO2 mixture (CH4\/NO-SCRreaction). Molecules of NO and NO2 were shown to become activated together as NO+\/NO3&#8722; ion pair inreaction with [InO]+\/[InOH]2+ or Co2+\/[Co-OH]+ sites. Operando DRIFTS results suggested that the reactionof methane and NO3&#8722; generates an intermediate that rapidly reacts with the NO+ to give N2. Thepromoting effect of the cobalt was related to the significantly higher NO-COX activity of Co-oxide clustersthan that of the Brønsted acid sites. The accelerated NO-COX reaction speeds up the formation ofNO+\/NO3&#8722; species and the rate of the methane activation, being the rate-determining step of the NO-SCRreaction. It was also shown that the NO-SCR reaction can proceed if NO-COX and CH4\/NO-SCR active sitesare separated in space. In order to avoid rate controlling NO2 transport between the sites close proximityof the sites is favorable","palabras_clave":"In,H-ZSM-5|SCR|Operando DRIFTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88563,"idioma_id":4,"titulo":"Effect of Ag-Co interactions in the mordenite on the NOx SCR with butane and toluene","resumen":"A study of the lean NOx reduction activity with butane and toluene in the presence of water over bimetallicand monometallic Ag, Co exchanged on Na-mordenite catalysts was performed. The Ag\u2013Co interactions wereanalyzed through X-ray photoelectron spectroscopy (XPS) and temperature-programmed reduction (TPR)techniques. It is shown that the metal silver particles formed at low temperature during the TPR experimentimprove the dissociation of hydrogen thus facilitating the reduction of Co2+ species. The incorporation of3.2 wt.% of silver to CoM catalyst, significantly improved the NOx to N2 conversion with butane, whichreached 95% under wet conditions (2% H2O). However, this effect was not observed when toluene was thereducing agent.x reduction activity with butane and toluene in the presence of water over bimetallicand monometallic Ag, Co exchanged on Na-mordenite catalysts was performed. The Ag\u2013Co interactions wereanalyzed through X-ray photoelectron spectroscopy (XPS) and temperature-programmed reduction (TPR)techniques. It is shown that the metal silver particles formed at low temperature during the TPR experimentimprove the dissociation of hydrogen thus facilitating the reduction of Co2+ species. The incorporation of3.2 wt.% of silver to CoM catalyst, significantly improved the NOx to N2 conversion with butane, whichreached 95% under wet conditions (2% H2O). However, this effect was not observed when toluene was thereducing agent.\u2013Co interactions wereanalyzed through X-ray photoelectron spectroscopy (XPS) and temperature-programmed reduction (TPR)techniques. It is shown that the metal silver particles formed at low temperature during the TPR experimentimprove the dissociation of hydrogen thus facilitating the reduction of Co2+ species. The incorporation of3.2 wt.% of silver to CoM catalyst, significantly improved the NOx to N2 conversion with butane, whichreached 95% under wet conditions (2% H2O). However, this effect was not observed when toluene was thereducing agent.2+ species. The incorporation of3.2 wt.% of silver to CoM catalyst, significantly improved the NOx to N2 conversion with butane, whichreached 95% under wet conditions (2% H2O). However, this effect was not observed when toluene was thereducing agent.ficantly improved the NOx to N2 conversion with butane, whichreached 95% under wet conditions (2% H2O). However, this effect was not observed when toluene was thereducing agent.2O). However, this effect was not observed when toluene was thereducing agent.","palabras_clave":"Ag-Co interaction|NOx|butane|toluene"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88564,"idioma_id":4,"titulo":"FTIR studies of butane, toluene and nitric oxide adsorption on Ag exchanged NaMordenite","resumen":"In this work, we studied the adsorption of butane, toluene and nitric oxide on NaMordenite exchanged with different amounts of silver. The reactions that occurred when the adsorbed hydrocarbons interacted with NO and the effect of water adsorption were also addressed. Different silver species were formed after ion exchange and they were detected by TPR analysis. Highly dispersed Ag2O particles were reduced at temperatures lower than 300 °C whereas Ag+ exchanged ions showed two TPR peaks, which can be ascribed to species exchanged at different mordenite sites. The TPD experiments after adsorption of NO at 25 °C showed that the only desorbed species was NO2 which was formed by the total reduction of Ag2O particles. When the adsorbed butane was exposed to NO (1000 ppm), isocyanate species were formed on Ag+ ionic sites as well as Ag+?(NOx)?CO species. Toluene adsorption was stronger than butane since adsorbed toluene molecules were held even at 400 °C. The characteristic bands of the aromatic ring C=C bond was observed as well as that of methyl groups interacting with Ag+ and Na+ ions. However, the appearance of carboxylic groups at temperatures above 300 °C in inert flow indicated the partial oxidation of toluene due to Ag2O species present in the samples. After contacting adsorbed toluene with NO, different FTIR bands correspond to organic nitrocompounds, isocyanate, cyanide and isocyanide species adsorbed on Ag+ ions, were detected. The presence of water inhibited the formation of NO2 species and the hydrocarbon adsorption on Na+ sites but did not affect the toluene-Ag+ interaction.","palabras_clave":"HYDROCARBON ADSORPTION|AG-MORDENITE|FTIR SPECTROSCOPY|NOX SELECTIVE REDUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88565,"idioma_id":4,"titulo":"Biodiesel Production by Two-Stage Transesterification with Ethanol By Washing with Neutral Water and Water Saturated with Carbon Dioxide","resumen":"In order to meet the conversion values established by international standards, a two-stage process for the production of ethanol-based biodiesel was proposed in a previous work. The industrial production of ethyl esters has as a challenge the purification step, due to the excessive amount of soaps formed in this process. In this work, a simple biodiesel washing treatment is presented, which allows the successful purification of samples containing high amounts of soaps, such as those obtained using ethanol. A complete process scheme for the ethyl esters production is proposed, which involves an esterification stage, with the aim of recovering the soaps thus obtaining yields close to the expected theoretical ones. The mass balances of this whole process were performed with data obtained in the laboratory. In addition, a number of quality parameters were measured and compared with the corresponding to the same samples obtained using methanol as transesterification alcohol.","palabras_clave":"BIODIESEL|ETHANOL|TRANSESTERIFICATION|WASHING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88566,"idioma_id":4,"titulo":"Borated zirconia modified with ammonium metatungstate as catalyst in alcohol acetylation","resumen":"Samples of tungsten-modified borated zirconia were prepared to be used as catalyst in 2-phenoxyethanol acetylation. The borated zirconias were obtained by impregnation of two zirconias (S2 and S4) obtained by the micellar method using different zirconium precursor concentrations with boric acid solution containing 0.3 moles B\/dm3. These solids and the parent zirconias were impregnated with two concentration levels of ammonium metatungstate solutions (0.11 and 0.22 moles W\/dm3). The solids containing boron mainly have amorphous characteristics and strong acidity, while those that contain only tungsten showed stronger acidity and evidence of the presence of a crystalline phase. The specific surface area and the pore volume slightly decreased in the solids obtained by adding tungsten to borated zirconia, and more markedly in those that contain only tungsten, and the mean pore size increased with respect to the parent support. It was observed that in the 2-phenoxyethanol acetylation using acetic acid as acylating agent and tungsten-modified borated zirconia as catalyst, the yield to acetylated product was high and it is correlated with the acid strength of the catalysts. In turn, the solids that contain only tungsten have a correlation with the acidity, but lead to low yield values due to a poorer dispersion of the tungsten species. The best yield was obtained with the catalyst prepared with the borated S4 zirconia containing 15% g B2O3\/100 g support and 12.5% g W\/100 g support. Using this catalyst and the same reaction conditions, the acetylation of different alcohols and phenols was studied, the reactivity order being as follows: primary alcohols > secondary alcohols > phenols.","palabras_clave":"Borated zirconia|Ammonium metatungstate|Acetylation|Alcohols"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88567,"idioma_id":4,"titulo":"Tungstophosphoric acid\/zirconia composites prepared by the sol gel method: An efficient and recyclable green catalyst for the one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes.","resumen":"Samples of zirconia modified with different contents of tungstophosphoric acid (TPA) were synthesizedfrom zirconium propoxide via sol\u2013gel reactions using polyethylene glycol as template and were characterizedby different physicochemical techniques (BET, XRD, FT-IR, and 31P MAS-NMR). The SBET of thesolids decreases and the microporosity increases with the increase of the TPA content. According to FT-IRand 31P MAS-NMR studies, the main species present in the samples is [PW12O40]3&#8722; anion, which was partiallytransformed into [P2W21O71]6&#8722; and [PW11O39]7&#8722; anions during the synthesis and drying steps. TheXRD patterns of the modified samples exhibit neither the characteristic peaks of TPA nor those attributedto its decomposition products.Aryl-14H-dibenzo[a,j]xanthenes have been synthesized by a one-pot condensation of 2-naphthol andaryl aldehydes, catalyzed by tungstophosphoric acid\/zirconia composites in a solvent-free medium usingconventional heating. The present approach offers the advantages of clean reaction, simple methodology,short reaction time, and high yield. The reaction work-up is very simple and the catalyst can beeasily separated from the reaction mixture and reused several times in subsequent reactions withoutappreciable loss of the catalytic activity.","palabras_clave":"Mesoporous zirconia|Heteropolyacids|14-Aryl-14H-dibenzo[a,j]xanthenes|Solvent-free reaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88568,"idioma_id":4,"titulo":"Structural synthesis of hydrophilic and hydrophobic silica for its use in food packaging films","resumen":"This study focuses on the synthesis of silica-based organic hybrids that can be used as fillers in plastics or adhesives with the aim of reducing their cost and improving the mechanical properties. Essentially, this work is intended to develop hybrid materials based on silica, with different surface properties modified by techniques such as functionalization using 3-aminopropyl triethoxysilane (APS) and 1,1,1,3,3,3 hexamethyldisilazane (HMDS) reagents as SiO2 modifiers with a view to their future employment as fillers in plastic films to be used as covers for different fruits. The materials were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM), textural properties, wettability measurements, and potentiometric titration with n-butylamine. Hydrophobic silicas were obtained when, in their synthesis, APS and HMDS were added as modifiers. Besides, their addition caused a large effect on the textural characteristics. The titration of the acidic sites of the modified silicas showed a sharp decrease in acidity compared to the unmodified silica. The TEM micrographs of the synthesized samples showed that the increase in HMDS amount aided to maintain the spherical shape of pure silica, increasing the formation of agglomerations and the primary particle size.","palabras_clave":"Sol-gel technique|SEM|TEM|Silica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88569,"idioma_id":5,"titulo":"'ASOCIACIÓN DE  BRIOFITAS DE LA FORMACIÓN LA CANTERA, APTIANO TARDÍO, CUENCA DE SAN LUIS,  ARGENTINA'","resumen":"Resumen. La Formacion La Cantera (Cretacico Temprano) ha brindado una importante palinoflora asociada a una diversa macroflora, ambas obtenidas de su localidad tipo, expuesta en la Sierra del Gigante, Cuenca de San Luis, centro-oeste de Argentina. Se ilustran y describenesporas de los generos Aequitriradites (Delcourt y Sprumont) emend. Cookson y Dettmann y Couperisporites Pocock, junto a diversos morfotipos vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.obtenidas de su localidad tipo, expuesta en la Sierra del Gigante, Cuenca de San Luis, centro-oeste de Argentina. Se ilustran y describenesporas de los generos Aequitriradites (Delcourt y Sprumont) emend. Cookson y Dettmann y Couperisporites Pocock, junto a diversos morfotipos vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.La Formacion La Cantera (Cretacico Temprano) ha brindado una importante palinoflora asociada a una diversa macroflora, ambas obtenidas de su localidad tipo, expuesta en la Sierra del Gigante, Cuenca de San Luis, centro-oeste de Argentina. Se ilustran y describenesporas de los generos Aequitriradites (Delcourt y Sprumont) emend. Cookson y Dettmann y Couperisporites Pocock, junto a diversos morfotipos vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.Aequitriradites (Delcourt y Sprumont) emend. Cookson y Dettmann y Couperisporites Pocock, junto a diversos morfotipos vegetales correspondientes a Bryophyta, recuperadas de los mismos niveles fosiliferos, aunque no en conexion organica. Como resultadode este nuevo analisis de la asociacion vegetal fosil obtenida (esporas dispersas y macrorrestos), se deduce un evidente predominio de esporasy megaflora con afinidad a las hepaticas, entre las briofitas. La ocurrencia de esporas y macrorrestos en los mismos sedimentos, pertenecientesal grupo de las hepaticas, y musgos, es indicativa del desarrollo in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.in situ (no hay evidencias de transporte) de este grupo de plantas bajo condiciones de humedad local, relacionadas a un cuerpo de agua dulce en este sector de la Cuenca de San Luis, durante el Aptiano tardio.","palabras_clave":"BRIOFITAS|FORMACION LA CANTERA|APTIANO TARDIO|SAN LUIS, ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88570,"idioma_id":4,"titulo":"Reproductive traits of the small Patagonian octopus Octopus tehuelchus","resumen":"This study evaluated the reproductive features of Octopus tehuelchus in three coastal environments of San Matías Gulf (Patagonia). Monthly samples of O. tehuelchus were used to estimate size at maturity, compare seasonal changes in oocyte size frequency distributions between  sites as well as oocyte number and size between female maturity stage and sites. Females in Islote Lobos had a smaller size at maturity than females in San Antonio Bay and El Fuerte, probably as a consequence of a generally smaller body size. Males in San Antonio Bay were smaller at maturity than females. O. tehuelchus is a simultaneous terminal spawner. Fecundity (expressed as number of vitellogenic oocytes in ovary) was lower in Islote Lobos, and an increase in oocyte number in relation to female total weight was found. Females in San Antonio Bay had the largest oocytes, which may indicate higher energy reserves for the embryo and therefore higher juvenile survival. There was a close relationship between reproduction, growth and condition, represented as size at maturity, number and size of vitellogenic oocytes and period of  maturity and spawning. Given the local variation in some reproductive features of O. tehuelchus, studies should focus on the environmental factors, which bring about this variation, and on how it affects the dynamics of local populations.","palabras_clave":"Reproductive pattern |Fecundity|Octopus tehuelchus|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88571,"idioma_id":4,"titulo":"'Catecholate Siderophores Protect Bacteria from Pyochelin Toxicity'","resumen":"Bacteria produce small molecule iron chelators, known as siderophores, to facilitate the acquisition of iron  from the environment. The synthesis of more than one siderophore and the production of multiple siderophore uptake  systems by a single bacterial species are common place. The selective advantages conferred by the multiplicity of  siderophore synthesis remains poorly understood. However, there is growing evidence suggesting that siderophores may  have other physiological roles besides their involvement in iron acquisition.  Methods and Principal Findings: Here we provide the first report that pyochelin displays antibiotic activity against some  bacterial strains. Observation of differential sensitivity to pyochelin against a panel of bacteria provided the first indications  that catecholate siderophores, produced by some bacteria, may have roles other than iron acquisition. A pattern emerged  where only those strains able to make catecholate-type siderophores were resistant to pyochelin. We were able to associate  pyochelin resistance to catecholate production by showing that pyochelin-resistant Escherichia coli became sensitive when  biosynthesis of its catecholate siderophore enterobactin was impaired. As expected, supplementation with enterobactin  conferred pyochelin resistance to the entE mutant. We observed that pyochelin-induced growth inhibition was independent  of iron availability and was prevented by addition of the reducing agent ascorbic acid or by anaerobic incubation. Addition  of pyochelin to E. coli increased the levels of reactive oxygen species (ROS) while addition of ascorbic acid or enterobactin  reduced them. In contrast, addition of the carboxylate-type siderophore, citrate, did not prevent pyochelin-induced ROS  increases and their associated toxicity.  Conclusions: We have shown that the catecholate siderophore enterobactin protects E. coli against the toxic effects of  pyochelin by reducing ROS. Thus, it appears that catecholate siderophores can behave as protectors of oxidative stress.  These results support the idea that siderophores can have physiological roles aside from those in iron acquisition.","palabras_clave":"SIDEROPHORES|PYOCHELIN|TOXICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88572,"idioma_id":4,"titulo":"Intensive fishery scenarios on the North Patagonian coast (Río Negro, Argentina) during the Mid-Holocene","resumen":"In contrast to what was recorded in other sectors of the Atlantic coast of continental Patagonia, evidence of intensive fishing activities has been found on the northern littoral of the San Matías Gulf (Río Negro, Argentina). The archaeological evidence of this practice, that go back to around 6000 14C BP, consists mainly of fish remains (white croaker otoliths) preserved on the surface of Pleistocene marine terraces together with weights for nets and other lithic artifacts involved in the primary processing of this resource. It is proposed that under the prevailing arid conditions in Mid-Holocene times in northeastern Patagonia, the productivity and particular configuration of the coast during the marine transgression at the studied localities would have offered a very favorable framework for the early development of this practice in the area.","palabras_clave":"COASTAL ARCHAEOLOGY|FISHING SCENARIOS|NORTHERN PATAGONIA|MIDDLE HOLOCENE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88573,"idioma_id":4,"titulo":"Structure and development of the style base in Abildgaardia, Bulbostylis, and Fimbristylis (Cyperaceae, Cyperoideae, Abildgaardieae)","resumen":"The Abildgaardieae tribe within the family Cyperaceae comprises six or seven genera, among which Abildgaardia, Bulbostylis and Fimbristylis pose a challenge regarding their morphological delimitation. Molecular phylogenetic analyses including species of Abildgaardieae are rare, but in most of those studies, Abildgaardia and Fimbristylis appear as more closely related to each other than to the Bulbostylis genus. Duration of the style base has been one of the most widely used characters for delimiting these three genera. The style base is a persistent structure in most species of Bulbostylis and deciduous in Abildgaardia and Fimbristylis. The reasons why the style base may persist or fall off have been scarcely discussed. The assumption that abscission layers are present in the style base of all three genera and the fact that tracheids have been observed in the style base of Bulbostylis suggest that this structure might have histological complexity. In view of this, a complete ontogenetic and anatomical study of the gynoecium has been carried out for all these three genera. It turned out that the style base is histologically simple in Abildgaardia, Bulbostylis and Fimbristylis and shows similar structure and development in all three genera. The fact that the style base has a shorter duration in Abildgaardia and Fimbristylis than in Bulbostylismight be related to the lower number of sclerotised cells that make up such structures in the mature fruit of the former two genera. Abscission of the style and style base may be the result of much simpler reasons than the differentiation of an abscission layer, resulting merely from mechanical shear force effects. Differences among genera have been observed in the shape of the style base and the development of the style. The histological simplicity of the style base is consistent with the homoplastic appearance of this structure in genera that are not closely related (e.g. Rhynchospora). Because of this, while the presence of the thickened style base seems to be a synapomorphy in species of Abildgaardieae, its persistence on or detachment from the fruit might have emerged repeatedly during this clade evolution and might not be a suitable character for genera delimitation.","palabras_clave":"Abilgaardia|Bulbostylis|Fmbristylis|Gynoecium|Ontogeny"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88574,"idioma_id":4,"titulo":"Structure of the Cyperaceae Inflorescence","resumen":"This work presents the basics for interpreting the adult inflorescencestructure in Cyperaceae. It provides an analysis of the variations of the synflorescenceand inflorescence structure in the family. Three types of synflorescence may berecognized in this family: a synflorescence with a foliate stem, a terminal inflorescenceand a variable number of lateral inflorescences; a synflorescence with a foliatestem and only the terminal inflorescence; and a synflorescence with a scape and aterminal inflorescence. Variations in the structure and form of the inflorescences arerelated to variations in inflorescence branching, inflorescence homogenization degree,presence or absence of the distal part of the inflorescence, phyllotaxis, inflorescenceposition, types of bracts and leaves subtending branches, elongation ofinflorescence internodes and spikelet structure. These variations are correlated withsome of the developmental processes that give origin to the inflorescence.","palabras_clave":"Cyperaceae|Synflorescence|Inflorescence|Homogenization process|Truncation proccess"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88575,"idioma_id":5,"titulo":"La rosuvastatina atenúa la progresión de la estenosis aórtica generada por hipertensión arterial, independientemente de sus efectos hipolipemiantes","resumen":"Introducción. Existe evidencia epidemiológica que vincula factores de riesgo cardiovascular con la estenosis valvular aórtica. Recientemente se ha demostrado el desarrollo de estenosis valvular aórtica en un modelo de hipertensión arterial en animales. Planteamos la hipótesis de que el tratamiento con rosuvastatina modifica esta transformación. Objetivo Evaluar el efecto de la rosuvastatina sobre el desarrollo de estenosis valvular aórtica. Material y métodos Se instrumentaron conejos NZ machos (n = 43) con el modelo 1-riñón 1-clip de Goldblatt para generar hipertensión arterial. Los animales fueron aleatorizados a: HT (n = 17) que no recibió otro tratamiento, HT+R (n = 14) tratado con rosuvastatina 2,5 mg\/kg\/día y HT+R+C (n = 12) tratado con rosuvastatina 2,5 mg\/kg\/día + suplemento de colesterol dietético para mantener los niveles basales de colesterol plasmático. Un grupo control (GC) fue sometido a cirugía simulada (n = 15). Las características de la válvula aórtica se midieron por ecografía en condiciones asales y a los 3 y a los 6 meses de hipertensión arterial. Resultados A los 6 meses de seguimiento, los incrementos de PAS y PAD fueron más elevados en HT (49% y 40%, respectivamente; p &lt; 0,001) en comparación con los grupos tratados con rosuvastatina (PAS = 23% y 25%; PAD = 28% y 26%; p &lt; 0,001 para HT+R y HT+R+C, respectivamente). El colesterol total se redujo el 45,7% (p &lt; 0,01) sólo en HT+R. El espesor valvar se incrementó en HT (0,50 ± 0,01 vs. 0,62 ± 0,02 mm; p &lt; 0,01), sin mostrar diferencias en HT+R y HT+R+C. Finalmente, el área valvular aórtica mostró una reducción en HT (0,277 ± 0,024 vs. 0,208 ± 0,014 cm2; p &lt; 0,05), sin cambios en HT+R y HT+R+C y un aumento no significativo en el GC (0,264 ± 0,022 vs. 0,32 ± 0,016 cm2; p = 0,07). Conclusiones La rosuvastatina atenúa la progresión de la estenosis valvular aórtica generada por hipertensión arterial. Esta protección podría ser mediada por efectos no hipolipemiantes de estas drogas.","palabras_clave":"ESTENOSIS AÓRTICA|HIPOLIPEMIANTES|EFECTOS PLEIOTROPICOS|HIPERTENSIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88576,"idioma_id":4,"titulo":"High TSH and low T4 as prognostic markers in older patients","resumen":"Objective: To describe the thyroid profile associated with increased morbid-mortality (MM) in hospitalized elderly in-patients. Design: Patients admitted to our institution between 2009-2010, over 60yr, were included. Individuals with thyroid function tests (TFT) were classified according to thyroid laboratory tests abnormalities and their clinical characteristics and outcome were analyzed. High MM was defined as mortality, intensive care unit (ICU) requirement or prolonged hospital stay (>18 days, 75th percentile), while long-term MM was defined adding mortality after 18 months following discharge.Results: From the 2599 patients admitted, 7% had TFT. Patients with TFT were mostly women and presented a more severe ill condition in comparison to the rest of the cohort. TFT patients were classified as 61%Non-thyroidal illness, 25%Euthyroid, 7% and 5% as overt hyper and hypothyroidism and 1% as subclinical hyper and hypothyroidism, respectively. Hypothyroid patients featured worse clinical outcomes than the others. Patients with increased MM exhibited higher TSH and lower TT4 (pConclusion: Among elderly in-patients with TFT both low TT4 and also high TSH might indicate a worse prognosis.","palabras_clave":"ELDERLY PATIENTS|THYROID|INTENSIVE CARE UNIT|THYROID HORMONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88577,"idioma_id":4,"titulo":"Multi-century tree-ring based reconstruction of the Neuquén River streamflow, northern Patagonia, Argentina","resumen":"In most cases, gauged river flow records in southern  South America extend for only a few decades, hampering  the detection of long-term, decadal to centennialscale  cycles and trends. Long streamflow series can be  reconstructed from tree-ring records, offering the opportunity  of extending the limited hydrological instrumental data  to several centuries. In northern Patagonia, Argentina, the  Neuqu´en River has great importance for local and national  socio-economic activities such as hydroelectric power generation,  agriculture and tourism. In this study, new and updated  tree-ring chronologies from Araucaria araucana and Austrocedrus  chilensis are used to reconstruct the October?June  mean streamflow for the Neuqu´en River and place the period  of gauged flows (1903?2009), in a long-term, multi-century  context. The reconstruction covers the period 1346?2000AD  and was developed from a network of 43 tree-ring chronologies,  grouped in composite series, using a nested principal  component regression approach. Analyses of the frequency,  intensity, and duration of droughts and pluvial events indicate  that the 20th century contains some of the driest and  wettest annual to decadal-scale events in the last 654 yr, but  longer and more severe events were recorded in previous centuries.  Blackman-Tukey and singular spectral analyses identified  quasiperiodic oscillations from 3.5 to 17.5 yr. A dominant  6.8-yr cycle explains ca. 23.6% of the total variance  in the Neuqu´en River streamflow reconstruction. Correlation  analyses showed that discharges of the Neuqu´en River are related to variations in the Southern Annular Mode (SAM), a  measure of air mass exchanges between middle and high latitudes  in the Southern Hemisphere. This association is consistent  with previous studies that indicate a strong correlation  between rainfall in northern Patagonia and SAM variations.","palabras_clave":"River streamflow|northern Patagonia|Tree-ring reconstruction|Araucaria araucana|Austrocedrus chilensis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88578,"idioma_id":4,"titulo":"Unusual Southern Hemisphere tree growth patterns induced by changes in the Southern Annular Mode","resumen":"Recent changes in the summer climate of the Southern Hemisphere extra-tropics are primarily related to the dominance of the positive phase of the Southern Annular Mode1,2. This shift in the behaviour of the Southern Annular Mode\u2014essentially a measure of the pressure gradient between Southern Hemisphere mid and high latitudes\u2014has been predominantly inducedby polar stratospheric ozone depletion2\u20134. The concomitant southward expansion of the dry subtropical belts5,6 could have consequences for forest growth. Here, we use tree-ring records from over 3,000 trees in South America, Tasmania and New Zealand to identify dominant patterns of tree growth in recent centuries.We showthat the foremost patterns of growth between 1950 and 2000 differed significantly from those inthe previous 250 years. Specifically, growth was higher than the long-term average in the subalpine forests of Tasmania and New Zealand, but lower in the dry-mesic forests of Patagonia. We further demonstrate that variations in the Southern Annular Mode can explain 12\u201348% of the tree growth anomalies in the latter half of the twentieth century. Tree-ring-based reconstructions of summer Southern Annular Mode indices suggest that the high frequency of the positive phase since the 1950s is unprecedented in the past 600 years.We propose that changes in the Southern Annular Mode have significantly altered tree growth patterns in the Southern Hemisphere.","palabras_clave":"tree rings|Southern Hemisphere|Southern Annular Mode|ozone depletion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88579,"idioma_id":5,"titulo":"Producción y calidad de gramíneas en un gradiente de calidades de sitio y coberturas en bosques de Nothofagus antarctica (G. Forster) Oerst. en Patagonia","resumen":"El presente estudio tuvo como objetivo cuantificar la producción y calidad de forraje de las gramíneas que conforman el sotobosque de bosques de Nothofagus antarctica(ñire) sometidos a aprovechamiento silvopastoril, que crecen bajo distinta disponibilidad de radiación. Se realizaron cortes mensuales de biomasa aérea durante dos estaciones de crecimiento en cinco rodales de ñire de calidad de sitio variable y en tres posiciones distintas (niveles de radiación): bajo las copas, entre copas y sin árboles. Además se evaluaron la radiación fotosintéticamente activa, las temperaturas del aire y del suelo, la humedad relativa del aire y la humedad del suelo. La producción de gramíneas varió entre sitios y niveles de radiación, con valores desde 135 a 1800 kg\/ha, y se correlacionó de manera positiva con la calidad de sitio del rodal. La incidencia de las variables ambientales sobre la producción de materia seca dependió del sitio y el año, aunque en la mayoría de los casos la producción de forraje dentro del bosque igualó o superó a la de las posiciones adyacentes sin árboles. La concentración de proteína de las gramíneas fue mayor dentro del bosque en los sitios de mejor calidad forestal, disminuyó a medida que avanzaba la estación de crecimiento y se asoció positivamente a la humedad del suelo en todos los sitios. Los resultados sugieren que el uso silvopastoril de bosques de ñire con coberturas intermedias puede ser conveniente desde el punto de vista de la cantidad y calidad forrajera.","palabras_clave":"sistemas silvopastoriles en ñire|bosque patagonico|produccion de forraje|calidad de forraje"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88580,"idioma_id":5,"titulo":"Elaboracion y caracterizacion de un atenuador de corriente para la linea E.D.R.A del acelerador TANDAR","resumen":"Con el objetivo de atenuar el micro haz del acelerador Tandar, se propuso un método para la elaboración de filtros de tantalio. Estos consisten en una lámina del metal con un espesor de 70 mm y un patrón de perforaciones de 100 mm de diámetro aproximadamente. Para obtener dichos filtros se consideraron distintas técnicas, entre ellas: ablación láser y ataques químicos selectivos, resultando esta última la de mayor factibilidad de realización.El patrón de perforaciones en la lámina de tantalio se logró mediante ataques químicos selectivos utilizando el método de fotolitografía. La mezcla utilizada fue HF: HNO3 en proporción 1:1. Debido a la fuerza ácida de la misma, se debieron realizar ataques en forma sucesiva alternadamente con la fotolitografía, para ello se utilizó el alineador de máscaras de la sala limpia del Departamento de Micro y Nanotecnología (CNEA).La lámina perforada se caracterizó con perfilometría óptica, microscopía óptica y microscopía electrónica de barrido.","palabras_clave":"Ta|ATAQUE QUÍMICO|FOTOLITOGRAFÍA|PERFILÓMETRO ÓPTICO|SEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88581,"idioma_id":4,"titulo":"The PmrAB-inducing conditions control both lipid A remodelling and O-antigen length distribution, influencing the Salmonella Typhimurium-host interactions","resumen":"The Salmonella enterica serovar Typhimurium lipopolysaccharide consisting of covalently linked lipid A, non-repeating core oligosaccharide and the O-antigen polysaccharide, is the most exposed component of the cell envelope. Previous studies demonstrated that all of these regions act against host immunity barrier. The aim of this study was to define the role and interaction of PmrAB-dependent gene products required for the lipopolysaccharide components synthesis or modification, mainly during the Salmonella infection. The PmrAB two-component system activation promotes a remodelling of lipid A and core region by addition of 4-aminoarabinose and\/or phosphoethanolamine. These PmrA-dependent activities are produced by activation of ugd, pbgPE, pmrC, cpta and pmrG transcription. In addition, under PmrA regulator activation the expression of wzzfepE and wzzst genes are induced and their products are required to determine the O-antigen chain length. We here report for the first time that Wzzst protein is necessary to maintain the balance of 4-aminoarabinose and phosphoethanolamine-lipid A modifications. Moreover, we demonstrate that the interaction of the PmrA-dependent pbgE2 and pbgE3 gene products is important for the formation of the short O-antigen region. Our results establish that PmrAB is the global regulatory system that controls lipopolysaccharide modification, leading to a coordinate regulation of 4-aminoarabinose incorporation and O-antigen chain length to respond against the host defense mechanisms.","palabras_clave":"LPS|MODIFICATIONS|SALMONELLA|TYPHIMURIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88582,"idioma_id":5,"titulo":"ESTIMACIÓN DE RECARGA DE ACUIFEROS EN AMBIENTES DE LLANURA CON BASE EN VARIACIONES DE NIVEL FREÁTICO","resumen":"La cuantificación del agua que entra al sistema hidrológico subterráneo es una de las principales incógnitas al momento de generar modelos hidrogeológicos tanto conceptuales como numéricos. Se entiende por recarga al acuífero, al agua que atraviesa el límite inferior de la zona no saturada, llega al acuífero y produce ascensos medibles en el nivel freático. En la actualidad existen diversas técnicas para cuantificarla, pero elegir la apropiada es a menudo difícil, especialmente por la necesidad de considerar la variación espacio-temporal, así como el rango y la fiabilidad de los datos usados por cada metodología. El objetivo de este trabajo es estimar el valor de la recarga al acuífero detrítico libre en el sudeste de la provincia de Buenos Aires sobre la denominada Llanura Interserrana Bonaerense, utilizando para esto el método de variación de nivel freático. Los resultados obtenidos establecen una recarga total variable entre 14.4 y 18.7% de la precipitación. Se plantean también datos de recarga mensual y datos de almacenamiento específico máximos, estos últimos con valores que oscilan entre 9.9 y 13.6%.","palabras_clave":"Recarga|Nivel freático|Almacenamiento Específico|Llanura interserrana Bonaerense"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88583,"idioma_id":5,"titulo":"Evaluación comparativa de métodos de cálculo de recarga en ambientes de llanura. La llanura interserrana bonaerense (Argentina) como caso de estudio.","resumen":"La recarga de un acuífero puede ser entendida como un proceso en el cual una porción laprecipitación infiltra en el suelo, drena a través del perfil no saturado y pasa a formar parte del agua subterránea. La determinación y cuantificación de este parámetro es de vital importancia para la planificación y gestión de los recurso hídricos. El objetivo de este trabajo es estimar los valores de recarga al acuífero pampeano en un sector de la llanura interserrana bonaerense mediante la aplicación de 4 metodologías diferentes, usando para esto datos hidroclimatológicos, químicos e hidrogeológicos. Las valores de recarga encontradas varían entre 9 y 21% del total de la precipitación con un valor medio total de 14%. Se discute en este trabajo sobre las ventajas y desventajas de las diferentes metodologías y se comparan sus resultados.","palabras_clave":"Acuifero|Recarga|Llanura pampeana|Nivel freático"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88584,"idioma_id":5,"titulo":"SURFACE AND GROUNDWATER POLLUTION BY ORGANOCHLORINE COMPOUNDS IN A TYPICAL SOYBEAN SYSTEM FROM THE SOUTH PAMPA, ARGENTINA","resumen":"Organochlorine pesticides (OCPs) use has been restricted or forbidden in Argentina since 1998 and technical endosulfan is the last currently used OCPs on the soybean-wheat production. As they persist in soil for several years after application, OCPs constitute a source of environmental pollution. This work aims to assess OCPs contamination of groundwater (Gw) and streamwater (Sw) in the Queque´n Grande River watershed from south Argentinean Pampas in relation to the hydrogeological characteristics. OCPs were analyzed in Sw, Gw, surface bottom sediments, soils and borehole cutting sediments (Cs) by gas chromatograph-electron capture detector. Pesticide distribution in Cs was dependent on the characteristic of the non-saturated zone. Leached pesticides over 3 m in Cs showed the pattern: HCHs = endosulfan[chlordanes[DDTs, and from 3 to 6 m heptachlor was the main group as a consequence of the past use of this compound in the area, mainly on potato crops. Endosulfan reaches Gw during application season as well as during flooding events while a retard effect was observed for Sw. Levels of a- and b-isomers were in certain cases above national (7 ng L-1) and international (3 ng L-1) limits for aquatic biota protection. As the endosulfan sulfate metabolite was present in Gw and Sw and due to its high toxicity,  it should be considered in the establishment of water quality criteria for human and environmental protection.","palabras_clave":"Organochlorine compounds|Water quality|Groundwater contamination|Watershed|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88585,"idioma_id":4,"titulo":"Prenatal hyperandrogenization induces metabolic and endocrine alterations which depend on the levels of testosterone exposure","resumen":"AbstractPrenatal hyperandrogenism is able to induce polycystic ovary syndrome (PCOS) in rats. The aim of the present study was toestablish if the levels of prenatal testosterone may determine the extent of metabolic and endocrine alterations during theadult life. Pregnant Sprague Dawley rats were prenatally injected with either 2 or 5 mg free testosterone (groups T2 and T5respectively) from day 16 to day 19 day of gestation. Female offspring from T2 and T5 displayed different phenotype ofPCOS during adult life. Offspring from T2 showed hyperandrogenism, ovarian cysts and ovulatory cycles whereas those fromT5 displayed hyperandrogenism, ovarian cysts and anovulatory cycles. Both group showed increased circulating glucoselevels after the intraperitoneal glucose tolerance test (IPGTT; an evaluation of insulin resistance). IPGTT was higher in T5 ratsand directly correlated with body weight at prepubertal age. However, the decrease in the body weight at prepubertal agewas compensated during adult life. Although both groups showed enhanced ovarian steroidogenesis, it appears that themolecular mechanisms involved were different. The higher dose of testosterone enhanced the expression of both theprotein that regulates cholesterol availability (the steroidogenic acute regulatory protein (StAR)) and the protein expressionof the transcriptional factor: peroxisome proliferator-activated receptor gamma (PPAR gamma). Prenatal hyperandrogenizationinduced an anti-oxidant response that prevented a possible pro-oxidant status. The higher dose of testosteroneinduced a pro-inflammatory state in ovarian tissue mediated by increased levels of prostaglandin E (PG) and the proteinexpression of cyclooxygenase 2 (COX2, the limiting enzyme of PGs synthesis). In summary, our data show that the levels oftestosterone prenatally injected modulate the uterine environment and that this, in turn, would be responsible for theendocrine and metabolic abnormalities and the phenotype of PCOS during the adult life","palabras_clave":"POLYCYSTIC OVARY SYNDROME|PRENATAL HYPERANDROGENIZATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88586,"idioma_id":4,"titulo":"Heterogeneity in genetic admixture across different regions of Argentina","resumen":"The population of Argentina is the result of the intermixing between several groups, including Indigenous American,European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individualsfrom different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers (AIMs) was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European (95%CI: 63\u201368%), 31% Indigenous American (28\u201333%)and 4% African (3\u20134%). We observed statistically significant differences in European ancestry across Argentine regions [Buenos Aires province (BA) 76%, 95%CI: 73\u201379%; Northeast (NEA) 54%, 95%CI: 49\u201358%; Northwest (NWA) 33%, 95%CI: 21\u201341%; South 54%, 95%CI: 49\u201359%; p,0.0001] as well as between the capital and immediate suburbs of Buenos Aires citycompared to more distant suburbs [80% (95%CI: 75\u201386%) versus 68% (95%CI: 58\u201377%), p = 0.01]. European ancestry among individuals that declared all grandparents born in Europe was 91% (95%CI: 88\u201394%) compared to 54% (95%CI: 51\u201357%) among those with no European grandparents (p,0.001). Our results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population.","palabras_clave":"ANCESTRY|ARGENTINA|MEDICAL RESEARCH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88587,"idioma_id":4,"titulo":"Y-Chromosomal STR haplotypes diversity in a sample from Metropolitan Area of Buenos Aires (Argentina)","resumen":"The aim of this work was to analyze the origin of the Y-chromosome haplotypes in a sample from Buenos Aires Metropolitan Area (BAMA), and to compare these results with data obtained at mitochondrial level. In order to reach this objective, 17 Y-STRs were determined from 85 unrelated blood donors. A total of 85 unique haplotypes were observed. The haplotype diversity was 1.000+\/-0.0018, and the average genetic diversity 0.680+\/-0.095. The paternal lineages present a genetic homogeneity of European roots (93%), coming mainly from Italy and Spain. Amerindian paternal contribution associated to sub-haplogroup Q1a3a was relatively low (6%). The low proportion of Amerindian haplotypes and the high number of maternal lineages (44%) from the same sample reveals that there has been a differential input by gender in the history of this population. A single profile was E1b1a, which is predominant in sub-Saharan Africa. These data, together with the historical and demographic information, allows us to state that the small Amerindian and sub-Saharan contribution observed in  the sample from BAMA, would be the result of recent migrations, initiated in the middle of twentieth century, mainly from the north of Argentina and bordering countries of high native composition and, to a less extent, African origin.","palabras_clave":"Y-chromosome|haplotypes|population genetics|Buenos Aires"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88588,"idioma_id":4,"titulo":"Production and turnover rates of shallow fine roots in rangelands of the Patagonian Monte, Argentina","resumen":"¡¡Abstract: We analyzed the relationship between organic C and N in the upper soil and the quantity (mass) and quality (N, soluble phenolic, and lignin concentrations) of plant aboveground litter and upper fine roots at contrasting microsites (plant patch and bare soil) in 15 study sites across an aridity gradient in Patagonia. At each site, we estimated the total, grass, and shrub cover and randomly selected 10 plant patches of modal size (height and crown diameter) and species composition. We extracted an upper soil core (0¨C10 cm depth) and collected the aboveground litter underneath each plant patch canopy and at the contiguous bare soil. We separated the fine roots (&lt; 2 mm in diameter) from the soil and assessed the biomass and the concentrations of organic C and N in soil and the lignin, soluble phenolic, and N in shrub and grass components of aboveground litter and in fine roots. Total plant and grass cover decreased with increasing aridity. Total litter mass did not vary across the aridity gradient, but the proportion of shrub components in litter increased and litter quality decreased with increasing aridity. The mass of fine roots was positively correlated to soil organic C and N and decreased with increasing aridity. All these trends were consistent at plant patch and bare soil microsites. We conclude that the decrease in soil organic C and N across the aridity gradient was the outcome of different above- and belowground controls resulting from the replacement of grasses by shrubs. Accordingly, the main controls of soil organic C and N could be the quality of aboveground litter and the quantity of the organic matter input to soil through fine-root turnover from belowground. &nbsp; ","palabras_clave":"ARID ECOSYSTEMS|FINE ROOT BIOMASS|N CONCENTRATION|SHRUB COVER|PERENNIAL GRASS COVER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88589,"idioma_id":5,"titulo":"Arqueología, Educación y Museos. Encuentros entre Investigadores y Comunidades Locales","resumen":"La investigación arqueológica se enriquece cuando se genera una interacción fluida entre los arqueólogos y las comunidades en que se llevan a cabo los trabajos de campo. Los actores sociales locales (por ejemplo, propietarios de campos, funcionarios públicos, directores de museos y escuelas, docentes, alumnos, vecinos) con los que, en general, los investigadores entablan más contacto, ocupan lugar central en el proceso de investigación. No sólo aportan información sobre la ubicación de los sitios arqueológicos, sino que colaboran con la organización y logística de los viajes e, incluso, participan de las tareas de campo. Esta relación, sin embargo, se vuelve discontinua debido a que no existen espacios formales donde la comunidad pueda apropiarse de los resultados de las investigaciones arqueológicas. Con este antecedente, el equipo de investigación nucleado en el Laboratorio 3 de la División de Arqueología del Museo de La Plata inició, en el año de 2009, un proyecto de extensión universitaria financiado por la UNLP. Este proyecto se orientó a promover y afianzar la interacción entre los saberes antropológicos y arqueológicos y los diferentes actores de las comunidades en las que se desarrollan los trabajos de investigación. A partir del vínculo con los museos regionales y las escuelas locales se organizaron talleres, charlas-debate y se diseñaron materiales didácticos para los museos. En los dos años de trabajo las actividades del proyecto se realizaron en 17 localidades y en ellas participaron más de 2.000 alumnos y 150 docentes de escuelas primarias y secundarias y un mayor número de público general.","palabras_clave":"EXTENSIÓN UNIVERSITÁRIA|ARQUEOLOGÍA|MUSEOS|COMUNIDADES LOCALES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88590,"idioma_id":4,"titulo":"Mass spectrometry of rhenium complexes: a comparative study by using LDI-MS, MALDI-MS, PESI-MS and ESI-MS","resumen":"A group of rhenium (I) complexes including in their structure ligands such as CF3SO3-, CH3CO2-, CO, 2,2\u2019-bipyridine, dipyridil[3,2-a:2\u20193\u2019-c]phenazine, naphthalene-2-carboxylate, anthracene-9-carboxylate, pyrene-1-carboxylate and 1,10-phenanthroline have been studied for the first time by mass spectrometry. The probe electrospray ionization (PESI) is an ESI-based ionization technique that generates electrospray from the tip of a solid metal needle. In this work, mass spectra for organometallic complexes&nbsp; obtained by PESI were compared with those obtained by classical ESI and high flow rate electrospray assisted by corona discharge (HF-ESI-CD), an ideal method to avoid decomposition of the complexes and to induce their oxidation to yield intact molecular cation radicals in gas state [M]+. and \/ or to produce their reduction yielding &nbsp;the gas species [M]-. . It was found that both techniques showed in general the intact molecular ions of the organometallics studied and provided additionally structure characteristic diagnostic fragments. &nbsp;As the rhenium complexes studied in the present work showed strong absorption in the UV-visible region, particularly at 355 nm, laser desorption ionization (LDI) mass spectrometry experiments could be conducted. Although intact molecular ions could be detected in a few cases, LDI mass spectra showed diagnostic fragments for characterization of the complexes structure. Furthermore, MALDI mass spectra were obtained. Nor-harmane, a compound with basic character was used as matrix and the intact molecular ions were detected in two examples, in negative ion mode as the [M]-. species. Results obtained with 2-[(2 E)-3-(4-tert-buthylphenyl)-2-methylprop-2-enylidene] malononitrile (DCTB) as matrix are also described. LDI experiments provided more information about the rhenium complex structures than the MALDI ones.","palabras_clave":"PESI|ESI|HF-ESI|norharmano"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88591,"idioma_id":4,"titulo":"Water-Soluble (Pterin)rhenium(I) Complex: Synthesis, Structural Characterization, and Two Reversible Protonation Deprotonation Behavior in Aqueous Solutions","resumen":"A new water-soluble complex, Re(CO)3(pterin)(H2O), was synthesized and characterized by 1H NMR and FTIR spec- troscopy, and by a combination of three mass spectrometry techniques: MALDI, probe electrospray ionisation (PESI), and ESI. Because, unlike most metal-pterin complexes, the ReI complex is quite soluble in water, appropriate single crys- tals could be obtained for structural X-ray analysis.We report here the first solid state molecular structure containing a pterin ligand coordinated to the Re(CO)3 core. This determi-nation revealed that strong H bonds between the hydrogen atom of the 2-amino group and crystallization water mole- cules give rise to a polymeric arrangement of Re(CO)3- (pterin)(H2O) complexes in the lattice. Protonation studies in aqueous solutions of the ReI complex showed two acid-base equilibriums with pKa1 = 3.9 and pKa2 = 8.8. pKa1 was as- signed to the protonation equilibrium at N3 of the pterin li- gand in the complex and pKa2 could be ascribed to the depro- tonation of a coordinated water molecule.","palabras_clave":"RHENIUM|N, O LIGANDS|ACIDITY|PTERIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88592,"idioma_id":4,"titulo":"Chemoimmunotherapy for advanced  gastrointestinal carcinomas A successful combination of gene therapy  and cyclophosphamide","resumen":"The combination of a single low dose of cyclophosphamide (Cy) with the adenovirus-mediated gene transfer of  interleukin-12 (AdIL-12) might represent a successful therapy for experimental gastrointestinal tumors. This approach has  been proven to revert immunosuppressive mechanisms elicited by cancer cells and to synergistically promote antitumor  immunity. In addition, this therapeutic regimen has been shown to be more efficient in achieving complete tumor  regressions in mice than the application of a metronomic schedule of Cy plus AdIL-12.","palabras_clave":"ADVANCED GASTROINTESTINAL CARCINOMAS|CYCLOPHOSPHAMIDE|GENE THERAPY|IMMUNOMODULATION|INTERLEUKIN-12"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88593,"idioma_id":4,"titulo":"Single low-dose cyclophosphamide combined with interleukin-12 gene therapy is superior to a metronomic schedule in inducing immunity against colorectal carcinoma in mice","resumen":"The use of conventional cytotoxic agents at metronomic schedules, alone or in combination with targeted agents or immunotherapy, is being explored as a promising anticancer strategy. We previously reported a potent antitumor effect of a single low-dose cyclophosphamide and interleukin-12 (IL-12) gene therapy against advanced gastrointestinal carcinoma, in mice. Here, we assessed whether the delivery of IL-12 by gene therapy together with metronomic cyclophosphamide exerts antitumor effects in a murine model of colorectal carcinoma. This combination therapy was able, at least in part, to reverse immunosuppression, by decreasing the number of regulatory T cells (Tregs) as well as of splenic myeloid-derived suppressor cells (MDSCs). However, metronomic cyclophosphamide plus IL-12 gene therapy failed to increase the number of tumor-infiltrating T lymphocytes and, more importantly, to induce a specific antitumor immune response. With respect to this, cyclophosphamide at a single low dose displayed a superior anticancer profile than the same drug given at a metronomic schedule. Our results may have important implications in the design of new therapeutic strategies against colorectal carcinoma using cyclophosphamide in combination with immunotherapy.","palabras_clave":"INTERLEUKIN 12|CANCER IMMUNOTHERAPY |CYCLOPHOSPHAMIDE|METRONOMIC DOSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88594,"idioma_id":4,"titulo":"Increased  hyaluronan  levels  and  decreased  dendritic  cell  activation  are associated  with  tumor  invasion  in  murine  lymphoma  cell  lines","resumen":"Hyaluronan (HA), a component of the extracellular matrix surrounding tumors, modulates tumor progression and the immune response. Dendritic cells (DC) may tolerize or stimulate immunity against cancer. In this report, we study the association between tumor progression, HA levels and DC activation in a lymphoma model. Mice injected with the cells with highest invasive capacity (LBR-) presented increased HA in serum and lymph nodes, and decreased DC activation in infiltrated lymph nodes and liver. These findings could be related to lack of an effective antitumor immune response and suggest that serum HA levels could have a prognostic value in hematological malignancies.","palabras_clave":"DENDRITIC CELLS|HYALURONAN|HYALURONAN SYNTHASES |HYALURONIDASES|LYMPHOMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88595,"idioma_id":4,"titulo":"Synergism between arsenite and proteasome inhibitor MG132 over cell death in myeloid leukaemic cells U937 and the induction of low levels of intracellular superoxide anion","resumen":"                  Abstract      Increased   oxygen species production has often been cited as a mechanism   determining synergism on cell death and growth inhibition effects of   arsenic-combined drugs. However the net effect of drug combination may   not be easily anticipated solely from available knowledge of   drug-induced death mechanisms. We evaluated the combined effect of   sodium arsenite with the proteasome inhibitor MG132, and the   anti-leukaemic agent CAPE, on growth-inhibition and cell death effect in   acute myeloid leukaemic cells U937 and Burkitt´s lymphoma-derived Raji   cells, by the Chou-Talalay method. In addition we explored the   association of cytotoxic effect of drugs with changes in intracellular   superoxide anion (O2-) levels. Our results showed that combined arsenite + MG132 produced low levels of O2-   at 6 h and 24 h after exposure and were synergic on cell death   induction in U937 cells over the whole dose range, although the   combination was antagonistic on growth inhibition effect. Exposure to a   constant non-cytotoxic dose of 80 &#956;M hydrogen peroxide together with   arsenite + MG132 changed synergism on cell death to antagonism at all   effect levels while increasing O2- levels. Arsenite + hydrogen peroxide also resulted in antagonism with increased O2- levels in U937 cells. In Raji cells, arsenite + MG132 also produced low levels of O2-   at 6 h and 24 h but resulted in antagonism on cell death and growth   inhibition. By contrast, the combination arsenite + CAPE showed high   levels of O2- production at 6 h and 24 h post   exposure but resulted in antagonism over cell death and growth   inhibition effects in U937 and Raji cells. We conclude that synergism   between arsenite and MG132 in U937 cells is negatively associated to O2- levels at early time points after exposure.","palabras_clave":"Leukemia|U937|Arsenite|Synergism|Superoxide anion|Flow Cytometry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88596,"idioma_id":4,"titulo":"Morphological Quantification of Polymer Nanofibers in Tissue Engineering Images","resumen":"The design and fabrication of highly porous polymeric or composite scaffolds for tissue engineering and organ regeneration are keystones to advance in these interdisciplinary research areas. The development of biocompatible polymeric ma-trices with particular morphologies that promote a specific biological response for each type of cell, is strongly needed. To attain this goal, the characteri-zation and quantification of the morphological prop-erties of the scaffolds are necessary to correlate them to mechanical and biological properties.In this work, micro\/nanofibrous scaffolds ob-tained by electrospinning were characterized by scanning electron microscopy (SEM). The use of the granulometric size function, computed from the scaf-fold images, to develop algorithms that help the spe-cialists in the characterization of the shape, size, stocking density and orientation of the arrays, is proposed. The obtained results show that the analysis of SEM images allows for a good characterization of fibrous scaffolds becoming a useful tool for spe-cialists in this research area.","palabras_clave":"DIGITAL|MORPHOLOGY|ELECTROSPINNING|POLYMERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88597,"idioma_id":5,"titulo":"Metodos tiempo-frecuencia basados en la transformada wavelet","resumen":"La información contenida en una señal analógica se evidencia por  su representación numérica. El par de Fourier en dos representaciones  complementarias explicita las estructuras temporales y frecuenciales.  Para detectar y caracterizar eventos que combinan esas estructuras  en diversos y complejos patrones es necesario implementar métodos  más refinados de representación conjunta tiempo-frecuencia.","palabras_clave":"Representaciones tiempo-frecuencia.|Transformada wavelet.|Análisis multiresolución.|Paquetes de wavelets."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88598,"idioma_id":5,"titulo":"Explorando con los primos: un tema que tiene historia","resumen":"En el presente trabajo se describen experiencias con números primos en distintos niveles educativos, pasando por el reconocimiento de los números primos, la Criba de Eratóstenes, los primos de Fermat y los polígonos construibles","palabras_clave":"NÚMEROS PRIMOS|EXPERIENCIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88599,"idioma_id":5,"titulo":"Los agroquímicos y su impacto en los anfibios: un dilema de difícil solución","resumen":"En el presente trabajo se reseña la problemática ambiental relacionada con la aplicación deagroquímicos, en particular con respecto a su impacto sobre organismos no-blanco como losanfibios anuros de la región centro-este de la Argentina. Se detallan los principalesbiomarcadores no destructivos que permiten detectar la presencia de estresantes ambientalesy su importancia como herramientas en los programas de monitoreo para la protección de lafauna silvestre. Se discute también sobre el polémico herbicida glifosato y las perspectivas para las generaciones futuras.","palabras_clave":"Anfibios |Agroquímicos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88600,"idioma_id":4,"titulo":"Phylogeography of the catfish Hatcheria macraei reveals a negligible role of drainage divides in structuring populations","resumen":"Southern South America provides a set of unusual geographic features that make it particularly interesting for studying phylogeography. The Andes Mountains run along a north-to-south axis and act as a barrier to gene flow for much of the biota of this region, with southern portions experiencing extensive historical glaciation. Geological data  reveal a series of drainage reversals, shifting from Pacific Ocean outlets to Atlantic Ocean outlets because of glacier formation that dammed and reversed rivers. Once glaciers melted around 13 000 years ago, drainages returned to the Pacific Ocean. This geologic history predicts that aquatic organisms in Pacific rivers should have their closest relationships to their counterparts in Atlantic rivers immediately to their east. We tested this prediction in the trichomycterid catfish Hatcheria macraei from 38 locations using the mitochondrial cytochrome b gene. Our results show that most populations found in Pacific rivers were closely related to fish found in the adjacent Atlantic draining R&#305;´o  Chubut. Surprisingly, one documented drainage reversal (from R&#305;´o Deseado into Río Baker) did not result in movement of H. macraei. Overall, we found the lowest levels of genetic structure between most Pacific rivers that are adjacent to the Atlantic draining Río Chubut. We also found low levels of population structuring among three of four contemporary river basins that drain to the Atlantic Ocean. Our findings suggest that  drainage basin boundaries have historically not played an important long-term role in structuring between nine of 11 drainages, an unusual finding in freshwater biogeography.","palabras_clave":"Andes mountains |biogeography|cytochrome b|drainage reversal| glaciation| introgression|trichomycteridae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88601,"idioma_id":5,"titulo":"Impacto de las tecnologías de la información y la comunicación (TIC) en los docentes de la Facultad de Ingeniería de la Universidad Nacional de Lomas de Zamora: el caso red de docentes","resumen":"Se presentan los resultados de un estudio de caso en el que se analiza la participación y la contribución de las intervenciones de los Foros en una comunidad virtual de aprendizaje. Se trabaja sobre una actividad formativa sobre estrategias evaluación de los aprendizajes por competencias dirigido a docentes de la Facultad de Ingeniería de la Universidad Nacional de Lomas de Zamora, que fue impartido en la modalidad de Blended Learning Se trata de un estudio de diseño cuasi experimental, en el que el grupo tuvo como elemento de cohesión formar parte del cuerpo de docentes de la Facultad y la orientación hacia la reflexión sobre las estrategias de evaluación . Se utilizan para el análisis de los datos, técnicas cuali cuantitativas","palabras_clave":"TECNOLOGIAS DE LA INFORMACION Y COMUNICACION|RED DOCENTE|APRENDIZAJE COLABORATIVO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88602,"idioma_id":4,"titulo":"Improvement in executive function after unilateral carotid artery stenting for severe asymptomatic stenosis","resumen":"Object Executive functions are crucial for organizing and integrating cognitive processes. While some studies have assessed the effect of carotid artery stenting (CAS) on cognitive functioning, results have been conflicting. The object of this study was to assess the effect of CAS on cognitive status, with special interest on executive functions, among patients with severe asymptomatic internal carotid artery (ICA) stenosis. Methods The authors prospectively assessed the neuropsychological status of 20 patients with unilateral asymptomatic extracranial ICA stenosis of 60% or more by using a comprehensive assessment battery focused on executive functions before and after CAS. Individual raw scores on neuropsychological tests were converted into z scores by normalizing for age, sex, and years of education. The authors compared baseline and 3-month postoperative neuropsychological scores by using Wilcoxon signed-rank tests. Results The mean preoperative cognitive performance was within normal ranges on all variables. All patients underwent a successful CAS procedure. Executive function scores improved after CAS, relative to baseline performance as follows: set shifting (Trail-Making Test Part B: -0.75 ± 1.43 vs -1.2 ± 1.48, p = 0.003) and processing speed (digit symbol coding: -0.66 ± 0.85 vs -0.97 ± 0.82, p = 0.035; and symbol search: -0.24 ± 1.32 vs -0.56 ± 0.77, p = 0.049). The benefit of CAS for working memory was marginally significant (digit span backward: -0.41 ± 0.61 vs -0.58 ± 0.76, p = 0.052). Both verbal (immediate Rey Auditory Verbal Learning Test: 0.35 ± 1.04 vs -0.22 ± 0.82, p = 0.011) and visual (delayed Rey-Osterrieth Complex Figure: 0.27 ± 1.26 vs -0.22 ± 1.01, p = 0.024) memory improved after CAS. Conclusions The authors found a beneficial effect on executive function and memory 3 months after CAS among their prospective cohort of consecutive patients with unilateral and asymptomatic ICA stenosis of 60% or more.","palabras_clave":"Executive Function|Unilateral carotid artery stenting |Severe asymptomatic stenosis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88603,"idioma_id":4,"titulo":"The relationship between executive functions and fluid intelligence  in Parkinson's disease.","resumen":"BACKGROUND:     We recently demonstrated that decline in fluid   intelligence is a substantial contributor to frontal deficits. For some   classical ´executive´ tasks, such as the Wisconsin Card Sorting Test   (WCST) and Verbal Fluency, frontal deficits were entirely explained by   fluid intelligence. However, on a second set of frontal tasks, deficits   remained even after statistically controlling for this factor. These   tasks included tests of theory of mind and multitasking. As frontal   dysfunction is the most frequent cognitive deficit observed in early   Parkinson´s disease (PD), the present study aimed to determine the role   of fluid intelligence in such deficits.MethodWe assessed patients with   PD (n=32) and control subjects (n=22) with the aforementioned frontal   tests and with a test of fluid intelligence. Group performance was   compared and fluid intelligence was introduced as a covariate to   determine its role in frontal deficits shown by PD patients.    RESULTS:     In   line with our previous results, scores on the WCST and Verbal Fluency   were closely linked to fluid intelligence. Significant patient-control   differences were eliminated or at least substantially reduced once fluid   intelligence was introduced as a covariate. However, for tasks of   theory of mind and multitasking, deficits remained even after fluid   intelligence was statistically controlled.    CONCLUSIONS:     The   present results suggest that clinical assessment of neuropsychological   deficits in PD should include tests of fluid intelligence, together with   one or more specific tasks that allow for the assessment of residual   frontal deficits associated with theory of mind and multitasking.","palabras_clave":"executive functions|intelligence |Parkinson's disease"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88604,"idioma_id":4,"titulo":"Insular networks for emotional processing and social cognition: comparison of two case reports with either cortical or subcortical involvement","resumen":"INTRODUCTION:    The processing of the emotion of disgust is attributed to the insular cortex (IC), which is also responsible for social emotions and higher-cognitive functions. We distinguish the role of the IC from its connections in regard to these functions through the assessment of emotions and social cognition in a double case report. These subjects were very rare cases that included a focal IC lesion and a subcortical focal stroke affecting the connections of the IC with frontotemporal areas.    MATERIALS & METHODS:  Both patients and a sample of 10 matched controls underwent neuropsychological and affective screening questionnaires, a battery of multimodal basic emotion recognition tests, an emotional inference disambiguation task using social contextual clues, an empathy task and a theory of mind task.    RESULTS:  The insular lesion (IL) patient showed no impairments in emotion recognition and social emotions and presented with a pattern of delayed reaction times (RTs) in a subset of both groups of tasks. The subcortical lesion (SL) patient was impaired in multimodal aversive emotion recognition, including disgust, and exhibited delayed RTs and a heterogeneous pattern of impairments in subtasks of empathy and in the contextual inference of emotions.    CONCLUSIONS:    Our results suggest that IC related networks, and not the IC itself, are related to negative emotional processing and social emotions. We discuss these results with respect to theoretical approaches of insular involvement in emotional and social processing and propose that IC connectivity with frontotemporal and subcortical regions might be relevant for contextual emotional processing and social cognition.","palabras_clave":"INSULAR CORTEX|SUBCORTICAL LESION|SOCIAL COGNITION|INSULAR LESION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88605,"idioma_id":4,"titulo":"Integrating intention and context: assessing social cognition in adults with Asperger syndrome","resumen":"Deficits in social cognition are an evident clinical feature of the Asperger syndrome (AS). Although many daily life problems of adults with AS are related to social cognition impairments, few studies have conducted comprehensive research in this area. The current study examined multiple domains of social cognition in adults with AS assessing the executive functions (EF) and exploring the intra and inter-individual variability. Fifteen adult´s diagnosed with AS and 15 matched healthy controls completed a battery of social cognition tasks. This battery included measures of emotion recognition, theory of mind (ToM), empathy, moral judgment, social norms knowledge, and self-monitoring behavior in social settings. We controlled for the effect of EF and explored the individual variability. The results indicated that adults with AS had a fundamental deficit in several domains of social cognition. We also found high variability in the social cognition tasks. In these tasks, AS participants obtained mostly subnormal performance. EF did not seem to play a major role in the social cognition impairments. Our results suggest that adults with AS present a pattern of social cognition deficits characterized by the decreased ability to implicitly encode and integrate contextual information in order to access to the social meaning. Nevertheless, when social information is explicitly presented or the situation can be navigated with abstract rules, performance is improved. Our findings have implications for the diagnosis and treatment of individuals with AS as well as for the neurocognitive models of this syndrome.","palabras_clave":"ASPERGER|SOCIAL NEUROSCIENCE|CONTEXT|EMPAHTY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88606,"idioma_id":4,"titulo":"P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia","resumen":"Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available to identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use of combined markers for dementia to enhance the prediction accuracy of assessment methods. The present study adhered to this proposal and investigated the sensitivity and specificity of the electrophysiological component P300 and standard neuropsychological tests to assess patients with Alzheimer\u2019s disease (AD) and MCI recruited from a low-income country. The neuropsychological battery comprised tests of memory, attention, language, praxis, and executive functions. The P300 was recorded using a classical visual odd-ball paradigm. Three variables were found to achieve sensitivity and specificity values above 80% (Immediate and Delayed recall of word list \u2013 CERAD \u2013 and the latency of P300) for both MCI and AD. When they entered the model together (i.e., combined approach) the sensitivity for MCI increased to 96% and the specificity remained high (80%). Our preliminary findings suggest that the combined use of sensitive neuropsychological tasks and the analysis of the P300 may offer a very useful method for the preclinical assessment of AD, particularly in populations with low socioeconomic and educational levels. Our results provide a platform and justification to employ more resources to convert P300 and related parameters into a biological marker for AD","palabras_clave":"Alzheimer\u2019s disease|mild cognitive impairment|event related potentials|P300|neuropsychology|early detection|preclinical markers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88607,"idioma_id":5,"titulo":"ANÁLISIS COMPARATIVO DE LAS CARACTERÍSTICAS MORFOLÓGICAS DE LOS ESTADOS INMADUROS DE LAS ESPECIES DEL GÉNERO CACTOBLASTIS RAGONOT PRESENTES EN LA QUEBRADA DE HUMAHUACA, JUJUY, ARGENTINA","resumen":"El objetivo del presente trabajo fue analizar las características morfológicas  de los estados inmaduros de C. doddi y compararlas con las de C. bucyrus para  lograr su identificación y diferenciación. Se describieron los estados de huevo, larva  y pupa de C. doddi. Para el análisis comparativo del estado larval se consideró  sólo el último estadio según lo propuesto por McFadyen (1985). Los huevos y las  larvas de C. doddi son más pequeños que los de C. bucyrus, mientras que las  pupas de ambas especies tienen tamaños similares. En cuanto al patrón de manchas,  las larvas del último estadio de estas especies se diferencian a nivel de tórax  y abdomen. Las manchas de las larvas de C. bucyrus se corresponde con las señaladas  por McFadyen (1985), mientras que el patrón de manchas de las larvas  de C. doddi no se ajusta completamente a la descripción de esta autora. La caracterización  morfológica de los estados inmaduros es una herramienta que ayuda  en la identificación de las especies de Cactoblastis pero es necesario realizar estudios  exhaustivos que incluyan además, aspectos bioecológicos a fin de lograr  la caracterización de cada especie.","palabras_clave":"CACTOBLASTIS DODDI|CACTOBLASTIS BUCYRUS|ESTADOS INMADUROS|CARACTERISTICAS MORFOLOGICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88608,"idioma_id":4,"titulo":"The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit\/hyperactivity disorder (ADHD)","resumen":"Attention-deficit\/hyperactivity disorder(ADHD)and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD.","palabras_clave":"ADHD|BIPOLAR DISORDER|DECISION-MAKING COGNITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88609,"idioma_id":4,"titulo":"Mesozoic coleopteran faunas from Argentina: geological context, diversity, taphonomic observations, and comparison with other fossil insect records","resumen":"The order Coleoptera is the most diversified group of the Class Insecta and is the largest group of the Animal Kingdom. Thiscontribution reviews the Mesozoic insects and especially the coleopteran records from Argentina, based on bibliographical andunpublished materials (86 described species, 526 collected specimens). The material came from different geological units from thelate Middle Triassic to the Late Triassic (Bermejo, Cuyo, and Malarg¨ue basins) to the Middle-Late Jurassic and Early Cretaceous(Deseado Massif, Ca˜nad´on Asfalto, and San Lu´ýs Basin). The coleopteran record is composed of 29 described species with 262collected specimens (isolated elytra) mainly represented by Triassic species and only four specimens recorded in Jurassic units, allof them currently unpublished. These fossil coleopterans provide fundamental information about the evolution of insects in theSouthern Hemisphere and confirm the Triassic Argentinean insect deposits to be among the most important in the world.fferent geological units from thelate Middle Triassic to the Late Triassic (Bermejo, Cuyo, and Malarg¨ue basins) to the Middle-Late Jurassic and Early Cretaceous(Deseado Massif, Ca˜nad´on Asfalto, and San Lu´ýs Basin). The coleopteran record is composed of 29 described species with 262collected specimens (isolated elytra) mainly represented by Triassic species and only four specimens recorded in Jurassic units, allof them currently unpublished. These fossil coleopterans provide fundamental information about the evolution of insects in theSouthern Hemisphere and confirm the Triassic Argentinean insect deposits to be among the most important in the world.","palabras_clave":"Coleoptera|Fossil|Mesozoic|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88610,"idioma_id":4,"titulo":"In vivo subcellular localization of Mal de Río Cuarto virus (MRCV) non structural proteins in insect cells reveals their putative functions","resumen":"The in vivo subcellular localization of Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and &#945;-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.","palabras_clave":"MRCV|Fijivirus|subcellular localization|non-structural proteins|GFP|confocal microscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88611,"idioma_id":4,"titulo":". Effect of uterine bacterial inflammation in donor mare plasmatic progesterone (pp4) at flushing time - is effluent analysis a helpful tool?","resumen":"Our objectives were to analyze the impact of uterine inflammation on PP4 at the time of embryo recovery and evaluate if exfoliative cytology (EC) andbacterial culture (BC) effluents from the embryo evaluation plate could be a useful tool in an Equine Embryo Transfer Program. This study was performed using Silla Argentino mares in Tandil, Argentina, between November 2011 and February 2012. Eighty six plasma samples and effluents were analyzed from 20 donor mares. Blood samples were taken from the jugular vein and immediately centrifuged. Separated plasma was stored at -20 C until analysis. Concentrations of P4 were analyzed by a RIA kit (Diagnostic Products Corporation, Los Angeles, CA, USA). Assay sensitivity of P4 was 0.1 ng ml1 and the intraassay coefficient of variation was less than 13% for concentrations between 0.1 and 40 ng ml1. Mares previously inseminated were flushed on day 7 or 8 post-ovulation and samples fromtheembryo evaluation platewere taken under laminar flow hood, and centrifuged. The sediment was used for analysis. Sterile swabs were used to prepare slides for cytology and a quick stain was used to identify Polymorphonuclear (PMN) cells in 10 fields at 1000X. An average >4 PMN´s were considered positive. Another swabwas used for bacteriology seeded in blood agar, and incubated for 48 h at 37C. More than 5 colonies was considered positive. Bacteriawere classifiedas gramnegative (G-) orpositive (G+) and typified. Criteria for embryo, cytology and culture were negative or positive. Comparisons of PP4 values were made fromflushings showing: EC&BC neg, EC&BC pos to G-, EC&BC positive to G+, and EC negative & BC +. Data were analyzed using the GraphPad Instat software support, Kruskal-wallis ANOVA test analysis was performed and the value obtained was P  0.05). G- bacteria were Pseudomonas aeruginosa (n: 9) and Escherichia coli (n: 1) and G+ were Streptococcus zooepidemicus (n: 5) and Staphylococcus aureus (n: 1).We concluded that based on this preliminary trial that plasmatic P4 showed different patterns according to bacterial strain and effluent samples showed to be useful at the time to decide if treatment in a donor mare should be necessary.","palabras_clave":"INFLAMMATION|PROGESTERONE|HORSES|ENDOMETRIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88612,"idioma_id":4,"titulo":"Effect of glucagon-like peptide 2 on hepatic, renal and intestinal disposition of 1-chloro-2,4-dinitrobenzene","resumen":"The  ability of the liver, small intestine, and kidney to synthesize and subsequently  eliminate dinitrophenyl glutathione  (DNP-SG), a substrate for multidrug resistance-associated protein 2 (Mrp2), was  assessed in rats treated with glucagon-like peptide 2 (GLP-2, 12 microg\/100  g b.wt. s.c. every 12 h for 5 consecutive days). An in vivo perfused jejunum  model with simultaneous bile and urine collection was used. A single  intravenous dose of 30 micromol\/kg b.wt. 1-chloro-2,4-dinitrobenzene (CDNB) was  administered, and its conjugate, DNP-SG, and dinitrophenyl cysteinyl glycine  (DNP-CG), resulting from the action of gamma-glutamyltransferase on DNP-SG, were determined in  bile, intestinal perfusate, and urine by highperformance liquid chromatography.  Tissue content of DNP-SG was also assessed in liver, intestine, and kidneys.  Biliary excretion of DNP-SG+DNP-CG was decreased in GLP-2 rats with respect to controls.  In contrast, their intestinal excretion was substantially increased, whereas  urinary elimination was not affected. Western blot and real-time polymerase  chain reaction studies revealed preserved levels of Mrp2 protein and mRNA in  liver and renal cortex and a significant increase in intestine in response to  GLP-2 treatment. Tissue content of DNP-SG detected 5 min after CDNB  administration was decreased in liver, increased in intestine, and unchanged in  kidney in GLP-2 versus control group, consistent with GLP-2-induced  down-regulation of expression of glutathione transferase (GST) Mu in liver and  up-regulation of GST-Alpha in intestine at both protein and mRNA levels. In  conclusion, GLP-2 induced selective changes in hepatic and intestinal  disposition of a common GST and Mrp2 substrate administered systemically that could  be of pharmacological or toxicological relevance under therapeutic treatment  conditions.","palabras_clave":"GLP-2|GST|Mrp2|IBD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88613,"idioma_id":4,"titulo":"Assessment of lettuce quality indices during storage at low relative humidity using the modified Global Stabiliy Index methodology","resumen":"During postharvest, lettuce is usually exposed to adverse conditions (e.g. low relative humidity) that reduce the vegetable quality. In order to evaluate its shelf life, a great number of quality attributes must be analyzed, which requires careful experimental design, and it is time consuming. In this study, the modified Global Stability Index method was applied to estimate the quality of butter lettuce at low relative humidity during storage discriminating three lettuce zones (internal, middle, and external). The results indicated that the most relevant attributes were: the external zone - relative water content, water content , ascorbic acid, and total mesophilic counts; middle zone - relative water content , water content, total chlorophyll , and ascorbic acid; internal zone - relative water content, bound water, water content, and total mesophilic counts. A mathematical model that takes into account the Global Stability Index and overall visual quality for each lettuce zone was proposed. Moreover, the Weibull distribution was applied to estimate the maximum vegetable storage time which was 5, 4, and 3 days for the internal, middle, and external zone, respectively. When analyzing the effect of storage time for each lettuce zone, all the indices evaluated in the external zone of lettuce presented significant differences (p < 0.05). For both, internal and middle zones, the attributes presented significant differences (p < 0.05), except for water content and total chlorophyll.Keywords: butter lettuce; quality indices; shelf life; mathematical modeling; weibull distribution","palabras_clave":"BUTTER LETTUCE|QUALITY INDICES|SHELF LIFE|MATHEMATICAL MODELING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88614,"idioma_id":4,"titulo":"Statistical optimization of a novel low-cost medium based on regional agro-industrial by-products for the production of proteolytic enzymes by Bacillus Cereus","resumen":"Bacillus sp. are specific producers of peptidase amongst bacteria and peptidase enzymes and are of significant ones due to their multifarious applications. Advances in industrial biotechnology offer potential opportunities for economic utilization of agro-industrial by-products for many biochemical reactions. Due to their rich organic nature, they can serve as an ideal substrate for the production of different value added products like peptidases. In the present work, an attempt was made to optimize different variables by Taguchi methodology for the production of peptidase using agro-industrial by-products hydrolyzed by a Bacillus cereus strain, resulting in brewer?s spent grain (BSG) being the optimal organic substrate. Subsequently, operative variables for the BSG were investigated using Taguchi methodology in order to maximize the enzyme production. Additionally, the main medium components were optimized using a mixture design. Finally, the production of peptidase by B. cereus was investigated; also the possible interaction with other proteolytic microbial strains was evaluated. A notorious synergistic effect was observed when B. cereus was inoculated with Pseudomonas sp. These brought a triple benefit, first, opening the possibility to produce technical enzymes at low cost, second, giving greater value to a food industry by-product, and third, reducing the environmental impact caused by the product removal directly into the environment.","palabras_clave":"MEDIUM OPTIMIZATION|MIXTURE DESIGN|PEPTIDASE|TAGUCHI DESIGN|STATISTICAL DESIGNS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88615,"idioma_id":4,"titulo":"QUALITY INDICES CHANGES IN PETIOLES OF CELERY (APIUM GRAVEOLENS L.) HARVESTED AT DIFFERENT PHYSIOLOGICAL STAGES","resumen":"Celery is a vegetable highly appreciated for its fiber content and nutritional value; petioles are preferred for consumption over the leaves. The aim of this study was to determine quality changes in petioles of self blanching celery (Apium graveolens L. ?Golden Boy?) harvested at different maturity stages. Total weight (TW), total length (TL), total leaves number (LN) and petiole length (PL) were evaluated at eight physiological stages: 80, 87, 94, 101, 108, 115, 122 and 129 days post-transplanting (dpt). Petiole quality of three zones (external, middle or internal) was analyzed in terms of: colour (hue angle), texture (cutting force), total soluble solids content and titratable acidity. From 80 to 129 dpt, TW and TL of plants increased from 309 to 2094 g and from 47.6 to 81.2 cm, respectively. TW reached a peak of 1.1 kg at 101 dpt. Weight continued increasing after 115 dpt, coinciding with the onset of flowering. Similar results were found for TL. Leaves development was detected until the fourth physiological stage; the number of internal leaves grew to a greater extent than in other zones, with values of 5.0, 4.7 and 7.3 leaves in external, middle and internal zone, respectively. Hue and cutting force were similar in external and middle petioles and were higher than values for internal petioles until the 5th and 6th harvests, respectively. Inflorescence differentiation was detected at 115 dpt, causing an increase in force to cut, TSS and TA. Under the conditions of this study, optimum quality was achieved at 122 dpt, given that yield and petiole quality reached a balance. Delayed harvest increased plant size but could be also associated with lower quality petioles, mainly due to an increase in fibrosity.","palabras_clave":"Crecimiento|textura|senescencia|bolting"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88616,"idioma_id":4,"titulo":"Polyvinyl Alcohol Pectin Cryogel Films for Controlled Release of Enrofloxacin","resumen":"The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at  pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C.  In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added  into the cryogel (PVA?P). A film containing 1.0% (w\/v) HM pectin and 5.0 &#956;g\/ml enro-  floxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed  that most of the interactions between PVA?P matrix and enrofloxacin were due to polar  groups (carboxylate and amine), a two-layer film system was designed to modulate the  releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to  41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin  was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel  system showed attractive features for transcutaneous antibiotic delivery.","palabras_clave":"Transcutaneous delivery |Enrofloxacin |PVA | Pectin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88617,"idioma_id":4,"titulo":"Controlled release of sulfasalazine release from 'smart' pectin gel microspheres under physiological simulated fluids","resumen":"Sulfasalazine (SLZ) is a synthetic nonsteroidal anti-inflammatory drug used mainly for the treatment of an inflammatory bowel and other diseases. Two pectins with different methylation degrees were blended to synthesized gel microspheres by ionotropic gelation for SLZ encapsulation. The encapsulation efficiency was found to be around of 99% in all formulations tested. However, different SLZ release profiles related to the methylation degrees of pectin were observed. Mixture of low methylated (LM) and high methylated (HM) pectins in the presence of calcium(II) displayed the best microsphere morphologies among the formulations tested determined by optical and electronic microscopies. The percentage of drug release using a mixture of LM and HM pectins after 255 min in simulated gastric fluid (pH&#8201;=&#8201;1.2), simulated intestinal fluid (pH&#8201;=&#8201;6.8), and phosphate buffer (pH&#8201;=&#8201;7.4) were 15.0%, 47.0%, and 52.2%, respectively.","palabras_clave":"PECTIN|HYDROGEL|DRUG DELIVERY|SULFASALAZINE|RHEOLOGICAL ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88618,"idioma_id":4,"titulo":"Cytogenetic and microtubule array effects of the zineb-containing commercial fungicide formulation Azzurro® on meristematic root cells of Allium cepa L","resumen":"Zineb [ethylene bis(dithiocarbamate) zinc] is a widely employed foliar fungicide for agricultural and industrial applications. Allium cepa L. is a reliable model for the assessment of xenobiotic genotoxicity  and cytotoxicity. We evaluated the effects of the zineb-containing commercial formulation Azzurro® (70% zineb) in cell cycle stages of the meristem root cells of A. cepa. The mitotic index (MI), chromosomal  aberrations at anaphase\/telophase (CAs), micronuclei (MN), and abnormalities in immunodetected microtubule structures, e.g., preprophasic band (PPB), mitotic spindle (MS), and phragmoplast (Phrag),  were used as end-points. Azzurro® (1 and 10 g\/ml) induced a significant increase in the frequency of CAs (P < 0.05), and the higher concentration inhibited the MI (P < 0.05) compared to control values.  The frequency of MN did not differ from control values at any concentration. Treatment with 1 g\/ml  Azzurro® induced a significant increase in the frequency of abnormal PPB (P < 0.01), MS (P < 0.001), and Phrag (P < 0.01) and, at 10 g\/ml, enhancements in the frequencies of abnormal MS (P < 0.05) and Phrag (P < 0.05) were seen. A tubulin immunodetection assay showed that exposure to Azzurro® interferes with normal assembly of microtubule structures during mitosis","palabras_clave":"Allium cepa |Zineb|Genotoxicity|Microtubules"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88619,"idioma_id":5,"titulo":"Circulación de obsidiana en Chubut, Patagonia Central, Argentina: uso de  las materias primas extra-regionales como indicadores de movilidad e interacción entre grupos cazadores recolectores","resumen":"Resumo: Os conjuntos de artefatos líticos recuperados em distintos tipos de sítios arqueológicos do Chubut mostram&nbsp;uma proeminência de matérias-primas locais, especialmente sílex, xilopalas e vulcanitas, nessa ordem.&nbsp;Esses materiais são acessíveis nas redondezas dos mesmos. As obsidianas, porém, aparecem em reduzida frequência e&nbsp;não se acham nas jazidas locais. O fato de haver fontes de obsidiana caracterizadas geo-quimicamente e&nbsp;localizadas pontualmente no espaço patagônico, possibilitou a identificação da origem dos achados nos resultados das&nbsp;análises geo-químicas de obsidianas de vários sítios no interior de Chubut e são discutidos em relação aos circuitos&nbsp;de mobilidade dos grupos humanos no espaço, estruturado pelas estradas. As conclusões apontam não&nbsp;apenas a existência de corredores de comunicação, mas também de&nbsp;encruzilhadas de caminhos, ao mesmo tempo em&nbsp; que se propõe&nbsp;o uso da obsidiana associado a aspectos sociais ou simbolicos, e não somente tecnológicos.","palabras_clave":"CENTRAL PATAGONIA|OBSIDIANS|HUNTER GATHERERS|MOBILITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88620,"idioma_id":4,"titulo":"A convenient one-pot synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones","resumen":"The synthesis of 1-aryl-substituted 2H-isoquinolin-3-ones is studied from 2-cyanomethylbenzoic acid and substituted benzenes via Friedel-Crafts acylation and intramolecular cyclization of 2-acylphenylacetonitriles formed in a one-pot method using sulfated zirconia as catalysts. Short reaction times, simplicity of operation, and easy work-up are some advantages of this method.","palabras_clave":"1-Aryl-substituted 2H-isoquinolin-3-ones|2-Acylphenylacetonitriles|Intramolecular cyclization|One-pot synthesis|Sulfated zirconia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88621,"idioma_id":4,"titulo":"Cooperative vigilance: The guanaco?s (Lama guanicoe) key antipredator mechanism","resumen":"The concept of sociality has been associated with the effectiveness of antipredator mechanisms, like cooperative vigilance and the dilution effect. Lama guanicoe (guanaco) is a social native herbivore in South America and a social species. The objectives of this study were to evaluate the antipredator responses of different-sized groups of guanacos in areas with varying predation risks and to determine antipredator mechanisms in guanacos. For this, we measured different antipredator responses to a potential predator (human subjects). Detection of predator and flight distances from predator both increased with a greater number of guanacos per group and with greater distances among guanacos within the social group. Both buffer distance and flight time decreased with a greater number of guanacos per group, but increased with greater distances among guanacos inside the social group. Solitary adult males moved shorter distance and mixed groups moved greater distances. Flight distances were greater in areas with tall and dense  vegetation than in areas with low vegetation. Buffer distance and flight time were shorter in undulating land than on flat lands, and groups were usually observed on hill slopes. Our results suggest that the benefit of social grouping in guanacos is the increased probability of avoiding predator with cooperative vigilance and not with the dilution effect. This means that a predator could be detected earlier when approaching a guanaco group than when approaching a solitary individuals and could thus be avoided.","palabras_clave":"COOPERATIVE VIGILANCE|DILUTION EFFECT|GROUP COHESION|LAMA GUANICOE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88622,"idioma_id":4,"titulo":"Dietary soybean meal on growth and intestinal morphology of South American catfish, Rhamdia quelen, larvae","resumen":"The effects of the replacement of bread yeast by soybean meal in diets for Rhamdia quelen larvae on growth, survival, and intestinal morphology were analysed. Larvae were fed for 20 days with five diets: a control diet formulated with 57% of bread yeast, and other four diets in which soybean meal at concentrations of 14.25, 28.5, 42.75 and 57% was added to obtain 25, 50, 75 and 100% of bread yeast replacement. Growth and survival parameters were negatively affected by dietary soybean meal inclusion. Larvae fed control diet showed significantly higher mean weight, specific growth rate, final biomass, and survival rate than larvae from other treatments. Enterocyte height and fold width of the posterior intestine showed highest values in the control group, and an inverse linear relationship with the level of dietary soybean meal inclusion was observed, however, in the anterior intestine the morphology parameters were not affected by the diet. These results indicate that inclusion of soybean meal in diets for R. quelen larvae negatively affects growth and survival, as well as the capacity for digestion and absorption of nutrients, mainly in the posterior intestine.","palabras_clave":"Pisciculturta|Larvicultura|Alimentación|Morfometría Intestinal"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88623,"idioma_id":4,"titulo":"Structural diversity of nuptial pads in Phyllomedusinae (Amphibia, Anura, Hylidae)","resumen":"We studied the morphological variation of the nuptial pads using light microscopy and scanning electron microscopy (SEM) in 26 species of phyllomedusines (Anura: Hylidae), representing the five currently recognized genera. All phyllomedusines have single nuptial pads with dark colored epidermal projections (EPs). Spine-shaped EPs occur in Cruziohyla calcarifer, Phrynomedusa appendiculata and in one species of Phasmahyla. The other species have roundish EPs. The density of the EPs on the pad is variable. Species in the Phyllomedusa hypochondrialis Group have EPs with a density that varies between 764 ± 58\/mm2 and 923 ± 160\/mm2. In all other studied species (including the Phyllomedusa burmeisteri and Phyllomedusa perinesos groups, Phyllomedusa camba, Phyllomedusa boliviana, Phyllomedusa sauvagii, Phyllomedusa bicolor, and Phyllomedusa tomopterna) the density of EPs varies between 108 ± 20\/mm2 and 552 ±  97\/mm2. Pores were observed with SEM in C. calcarifer, Agalychnis lemur, Agalychnis moreletii, but its presence is confirmed through histological sections on several other species. Its visibility using SEM seems to be related with the level of separation between adjacent EPs. The pores in the four studied species of Agalychnis are shown with SEM and histological sections to have a characteristic epidermal rim, that is absent in the other phyllomedusines. Unlike most previous reports on breeding glands, those of phyllomedusines are alcian blue positive, indicating the presence of acidic mucosubstances on its secretions.","palabras_clave":"PHYLLOMEDUSINAE|SCANNING ELECTRON MICROSCOPY|SECONDARY SEXUAL CHARACTERS|HISTOLOGY|ANURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88624,"idioma_id":4,"titulo":"A phylogenetic analysis of Pleurodema (Anura: Leptodactylidae: Leiuperinae) based on mitochondrial and nuclear gene sequences with comments on the evolution of anuran foam nests","resumen":"Species of the genus Pleurodema are relatively small, plump frogs that mostly occur in strong-seasonal and dry environments. Thegenus currently comprises 14 species distributed from Panama to southern Patagonia. Here we present a phylogenetic analysis ofPleurodema, including all described species and several outgroups. Our goals include testing its monophyly and the monophyly ofthe species groups that were historically proposed, and studying the evolution of some character systems, particularly macroglandsand egg-clutch structure; this last point also provided the chance for a discussion of foam nest evolution in anurans. Our datasetincludes portions of the mitochondrial genes cytochrome b, 12S, 16S, and the intervening tRNAVal; the nuclear gene sequencesinclude portions of rhodopsin exon 1 and seven in absentia homolog I. Our results support a clade composed of Pleurodema andincluding the monotypic Somuncuria Lynch, 1978 nested within it. The latter genus is therefore considered a junior synonym ofPleurodema and its sole species is added to this genus. Furthermore, our results indicate the non-monophyly of several speciesgroups proposed previously. We recognize four clades in Pleurodema: the P. bibroni clade (P. bibroni, P. cordobae and P. kriegi), theP. thaul clade (P. bufoninum, P. marmoratum, P. somuncurensis and P. thaul), the P. brachyops clade (P. alium, P. borellii,P. brachyops, P. cinereum, P. diplolister and P. tucumanum) and the P. nebulosum clade (P. guayapae and P. nebulosum). Ourresults further indicate the need for a taxonomic reassessment of P. borellii and P. cinereum (as did previous studies), P. guayapaeand P. nebulosum, and the three species in the P. bibroni clade. Pleurodema shows a striking pattern of variation in presence &#8260; absenceof lumbar glands. Our results indicate multiple losses or independent gains of this character associated with defensive displays. Thereproductive modes of Pleurodema include four different egg-clutch structures. The optimization of these indicates that there are atleast two independent transformations from the plesiomorphic mode of foam nests to egg-clutch structures involving gelatinousmasses of different sorts (ovoid plates, masses, or strings). We hypothesize that these independent transformations could involvechanges at the behavioural (the loss of foam beating behaviour by the parent) and &#8260; or structural level (transformations involving thepars convoluta dilata, the section of the oviduct where the foam-making substance is secreted). Finally, our study of foam nestevolution in Pleurodema is extended to the other groups of anurans where foam-nesting occurs, on the basis of available data andrecent phylogenetic hypotheses. In the different hyloid groups where it occurs, foam-nesting evolved from clutches laid in water.However, in all ranoids in which foam-nesting occurs, it evolved from terrestrial clutches, with eggs laid hanging in vegetation, or, ifthe clutches are laid on a restricted volume of water, involving endotrophic development.","palabras_clave":"Pleurodema|foam nest|phylogeny"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88625,"idioma_id":4,"titulo":"Evolution of Linear Motifs within the papillomavirus E7 oncoprotein","resumen":"Many protein functions can be traced to linear sequence motifs of less than  five residues, which are often found within intrinsically disordered  domains. In spite of their prevalence, their role in protein evolution is only  beginning to be understood. The study of papillomaviruses has provided  many insights on the evolution of protein structure and function. We have  chosen the papillomavirus E7 oncoprotein as a model system for the  evolution of functional linear motifs. The multiple functions of E7 proteins  from paradigmatic papillomavirus types can be explained to a large extent  in terms of five linear motifs within the intrinsically disordered N-terminal  domain and two linear motifs within the globular homodimeric C-terminal  domain. We examined the motif inventory of E7 proteins from over 200  known papillomavirus types and found that the motifs reported for  paradigmatic papillomavirus types are absent from many uncharacterized  E7 proteins. Several motif pairs occur more often than expected, suggesting  that linear motifs may evolve and function in a cooperative manner. The E7  linear motifs have appeared or disappeared multiple times during  papillomavirus evolution, confirming the evolutionary plasticity of short  functional sequences. Four of the motifs appeared several times during  papillomavirus evolution, providing direct evidence for convergent  evolution. Interestingly, the evolution pattern of a motif is independent of  its location in a globular or disordered domain. The correlation between the  presence of some motifs and virus host specificity and tissue tropism suggests  that linear motifs play a role in the adaptive evolution of papillomaviruses.","palabras_clave":"INTRINSIC DISORDER|SEQUENCE MOTIF|VIRUS|ADAPTIVE EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88626,"idioma_id":4,"titulo":"Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features","resumen":"Purpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with whitematter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance.We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.","palabras_clave":"Epilepsy|Focal Cortical Displasia|MRI|Source localization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88627,"idioma_id":4,"titulo":"Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)","resumen":"Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology\/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical,neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions\/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.","palabras_clave":"BIPOLAR_DISORDER|N170|TOM|SOCIAL_COGNITION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88628,"idioma_id":4,"titulo":"Association between equivalent current dipole source localization and focal cortical dysplasia in epilepsy patients","resumen":"Summary We analysed the association between focal cortical dysplasia (FCD) visible in MRIand the location of equivalent current dipole (ECD) of single interictal scalp EEG spikes (IIS) in11 epilepsy patients. We calculated several indicators of distance of ECDs to the FCD border.The results confirm some previous studies suggesting that the epileptogenic zone associated tothe location of ECDs extends beyond the FCD visible in MRI. The analysis suggests the ECDs tobe in a shell parallel to part of the FCD surface.","palabras_clave":"Focal cortical dysplasia|Equivalent current dipole|Magnetic resonance imaging|Inverse problem"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88629,"idioma_id":4,"titulo":"Effects of a large area glare source in cognitive efficiency and effectiveness in Visual Display Terminal work","resumen":"Abstract?Glare is a common visual stressor of office work and intoday?s offices the prevalence of information and communicationtechnologies adds additional mental demands. The aim of this studywas to explore the role of light as a cognitive stressor in visual displayterminal (VDT) work. We used a large area light source in a 2&nbsp;x 2&nbsp;x 2full factorial experimental design. We assessed cognitive efficiencyusing the RTLX method and cognitive effectiveness using the RSTmethod in different lighting scenarios. The main effects analysisshowed lower working memory capacity for high luminance and largesource, with statistically significant lower cognitive performance inprosaccade conditions. No statistically significant relationship wasfound between cognitive efficiency and the experimental factors. 2&nbsp;x 2full factorial experimental design. We assessed cognitive efficiencyusing the RTLX method and cognitive effectiveness using the RSTmethod in different lighting scenarios. The main effects analysisshowed lower working memory capacity for high luminance and largesource, with statistically significant lower cognitive performance inprosaccade conditions. No statistically significant relationship wasfound between cognitive efficiency and the experimental factors.today?s offices the prevalence of information and communicationtechnologies adds additional mental demands. The aim of this studywas to explore the role of light as a cognitive stressor in visual displayterminal (VDT) work. We used a large area light source in a 2&nbsp;x 2&nbsp;x 2full factorial experimental design. We assessed cognitive efficiencyusing the RTLX method and cognitive effectiveness using the RSTmethod in different lighting scenarios. The main effects analysisshowed lower working memory capacity for high luminance and largesource, with statistically significant lower cognitive performance inprosaccade conditions. No statistically significant relationship wasfound between cognitive efficiency and the experimental factors.full factorial experimental design. We assessed cognitive efficiencyusing the RTLX method and cognitive effectiveness using the RSTmethod in different lighting scenarios. The main effects analysisshowed lower working memory capacity for high luminance and largesource, with statistically significant lower cognitive performance inprosaccade conditions. No statistically significant relationship wasfound between cognitive efficiency and the experimental factors.","palabras_clave":"GLARE|WORKING MEMORY|VISUAL DISPLAY TERMINAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88630,"idioma_id":4,"titulo":"Chlordane biodegradation under aerobic conditions by indigenous Streptomyces strains","resumen":"Four actinobacteria strains isolated from pesticide-contaminated soil were able to grow in the presence of 16.6 mg L-1 chlordane, an organochlorine pesticide. The strain that showed best growth after 96 h of incubation in synthetic medium with chlordane as the sole carbon source was identi&#64257;ed as Streptomyces sp. A5. When Streptomyces sp. A5 was cultured in the presence of chlordane, the pesticide was degraded from the culture medium after 24 h of incubation. In soil assays, a reduction of 56% in -chlordane was observed after 28 days of incubation. This is the &#64257;rst report about chlordane degradation under aerobic conditions by a Streptomyces strain.","palabras_clave":"CHLORDANE|DEGRADATION|ACTINOBACTERIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88631,"idioma_id":4,"titulo":"Proteomic study of the yeast Rhodotorula mucilaginosa RCL-11 under copper stress","resumen":"In order to understand the mechanism involved in Rhodotorula mucilaginosa   RCL-11 resistance to copper a proteomic study was conducted. Atomic   absorption spectroscopy showed that the copper concentration              in the medium decreased from 0.5 to 0.19&nbsp;mM 48&nbsp;h after   inoculation of the yeast. Analysis of one-dimensional gel   electrophoresis              of crude cell extracts revealed expression of differential   bands between cells with and without copper. In order to study              this difference, two-dimensional electrophoresis of R. mucilaginosa   RCL-11 exposed to Cu for 16, 24, and 48&nbsp;h was carried out.   Identification of differentially expressed proteins was performed              by MALDI-TOF\/TOF. Ten of the 16 spots identified belonged to   heat shock proteins. Superoxide dismutase, methionine synthase              and beta-glucosidase were also found over-expressed at high   copper concentrations. The results obtained in the present work              show that when R. mucilaginosa RCL-11 is exposed to 0.5&nbsp;mM copper, differential proteins, involved in cell resistance mechanisms, are expressed.","palabras_clave":"PROTEOMIC|Rhodotorula|BIOREMEDIATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88632,"idioma_id":4,"titulo":"Unraveling the Amycolatopsis tucumanensis copper-resistome","resumen":"Heavy metal pollution is widespread causing  serious ecological problems in many parts of the  world; especially in developing countries where a  budget for remediation technology is not affordable.  Therefore, screening for microbes with high accumulation  capacities and studying their stable resistance  characteristics is advisable to define cost-effective any  remediation strategies. Herein, the copper-resistome  of the novel copper-resistant strain Amycolatopsis  tucumanensis was studied using several approaches.  Two dimensional gel electrophoresis revealed that  proteins of the central metabolism, energy production,  transcriptional regulators, two-component system,  antioxidants and protective metabolites increased their  abundance upon copper-stress conditions. Transcriptome  analysis revealed that in presence of copper,  superoxide dismutase, alkyl hydroperoxide reductase  and mycothiol reductase genes were markedly  induced in expression. The oxidative damage of  protein and lipid from A. tucumanensis was negligible  compared with that observed in the copper-sensitive  strain Amycolatopsis eurytherma. Thus, we provide  evidence that A. tucumamensis shows a high adaptation  towards copper, the sum of which is proposed as  the copper-resistome. This adaptation allows the strain  to accumulate copper and survive this stress; besides,  it constitutes the first report in which the copperresistome  of a strain of the genus Amycolatopsis with  bioremediation potential has been evaluated.","palabras_clave":"ACTINOBACTERIAS|COPPER|STRESS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88633,"idioma_id":4,"titulo":"Chlorpyrifos biodegradation and 3,5,6-trichloro-2-pyridinol production by actinobacteria isolated from soil","resumen":"Chlorpyrifos (CP) is a widely used agricultural insecticide that is hazardous to both the environment and  human health. Therefore, it is an essential to develop approaches to remove this compound from  contaminated soils, water and sediments. In this study, actinobacteria were isolated from an agricultural  soil that had received continuous applications of CP. Four strains were selected as a result of their  tolerance to 50 mg L1  of CP in agar plate and they were identi&#64257;ed as Streptomyces sp. based on 16S  rDNA. According to relationship of CP degradation and microbial growth studies, two isolates were  selected and were named Streptomyces sp. strain AC5 and Streptomyces sp. strain AC7. The strains were  cultivated in liquid medium with CP at concentrations of 25 mg L1  and 50 mg L1  for 72 h. The results  indicated that both strains were able to rapidly degrade CP with about 90% degradation after 24 h of  incubation. A different pattern of CP degradation was observed when its main metabolite, 3,5,6-  trichloro-2-pyridinol (TCP) was monitored. A maximum concentration of 0.46 mg L1  of TCP was  produced by Streptomyces sp. strain AC5 and its concentration decreased as a function of time. In  contrast, TCP production by Streptomyces sp. AC7 increased over time from 1.31 mg L1  to 4.32 mg L1  .CP  degradation was associated to microbial growth of the strains, pH modi&#64257;cation, glucose consumption  and organic acids excretion in the liquid medium. This work constitutes one of the few reports of  Streptomyces as CP-degraders. Given the high CP degradation observed here, the Streptomycetes strains  show a good potential as CP-degrading actinobacteria.","palabras_clave":"CHLORPYRIFOS|ACTINOBACTERIA|SOIL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88634,"idioma_id":4,"titulo":"Crevice Corrosion Study on Alloy 22 by Electrochemical Noise Technique","resumen":"Ni-Cr-Mo alloys show a remarkable corrosion resistance in a wide variety of environments. These alloys are candidate materials for the corrosion resistant engineered barriers of nuclear repositories. Ni-Cr-Mo alloys  are susceptible to crevice corrosion in aggressive conditions, such as high concentrations of chlorides, low pH and high temperatures. The aim of this study was to evaluate the application of electrochemical noise  technique to the study of crevice corrosion of alloy 22.  Potential and current noise records were obtained from alloy 22 samples with and without crevice formers in several corrosive environments. The obtained records were analyzed in the time domain, and through statistical parameters. The objective of this analysis was to obtain confident parameters to detect crevice corrosion.  Noise records obtained from tests where crevice corrosion occurred showed a clear drop in potential along with an increase of current. On the contrary, in the cases where there was no crevice corrosion, only a  gradual increase in the potential is observed in the noise potential records. Analyses over statistical parameters of the records show that the current noise standard deviation is sensitive to the corrosiveness of the environment (temperature and solution composition) and to the occurrence of crevice corrosion.  The results indicate that, within electrochemical noise technique, the voltage drop and the simultaneous increase in the current record are the most important parameters for monitoring crevice corrosion of alloy 22.  The analysis of the standard deviation of the current records may complement these measurements.","palabras_clave":"CREVICE CORROSION|C-22|ELECTROCHEMICAL NOISE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88635,"idioma_id":4,"titulo":"Effect of crevice corrosion inhibitors on the passivity of alloy 22","resumen":"Electrochemical impedance spectroscopy (EIS) tests were performed on alloy 22 in chloride and chloride plus inhibitor naturally                       aerated solutions, at 90°C. A R&#937;-(RF\/\/CPE) equivalent circuit model was used for fitting to the EIS data. R&#937; and RF   were the ohmic and film resistances, respectively, and CPE accounted   for the non-ideal capacitance. The fitting errors of                       the circuit parameters decreased as pH increased.   The passive film properties improved as pH increased from pH 0 to pH 4.                       At higher pH values, the passive film properties   depended mainly on the identity of the salt added. Oxalic, picric and   citric                       acids additions were detrimental for the passive   film developed on alloy 22. Carbonate and bicarbonate led to less   protective                       passive films only when added to 1 M NaCl   solutions. Fluoride was a detrimental addition at pH 6, but not at pH 9.   Acetic                       acid, carbonic acid, silicate, tungstate, and   molybdate additions did not modify significantly the protective   properties of                       the alloy 22 passive film. Nitrate, sulfate and   chromate additions led to thick and protective passive films. The   efficiency                       of the tested species as crevice corrosion   inhibitors was not related to their effects on alloy 22 passivity.","palabras_clave":"PASSIVE FILM|BICARBONATE|TUNGSTATE|MOLYBDATE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88636,"idioma_id":4,"titulo":"Patch choice from a distance and use of habitat information during foraging by the parasitoid Ibalia leucospoides","resumen":"In environments in which resources are distributed heterogeneously patch choice and the length of time spent on a patch by foragers are subject to strong  selective pressures. This is particularly true for parasitoids because their host foraging success translates directly into individual fitness. The aim of this study was to test whether: (i) females of the parasitoid Ibalia   leucospoides (Hymenoptera: Ibaliidae) can discriminate among patches according to  host numbers; (ii) the surrounding context affects the initial choice of patch, as well as time spent on patch; and (iii) the perceived quality of a given patch is affected by the quality of the surrounding patches. Each female was randomly exposed to one of three different three-patch environments which differed in host number per patch, mean environment host number and host distribution among patches. For each treatment level, the first patch chosen and the time allocated to each patch visited by the female were recorded. I. leucospoides were able to discriminate different levels of host numbers  among patches from a distance. The patch bearing the highest number of hosts was,predominantly, the first choice. Patch host number in association with mean habitatitability influenced the length of time spent on the first patch visited. By contrast,variance in habitat profitability did not influence time allocation decisions. Contrary to the study hypothesis, there were no significant habitat-dependent time allocation differences among patches holding the same number of hosts. The results indicate that, for I. leucospoides, patch exploitation decisions are   partially influenced by information obtained from the habitat as a whole, a behaviour that may prove to indicate adaptive ability in highly patchy environments, as well as suggesting the presence of good cognitive abilities in this parasitoid species","palabras_clave":"foraging behaviour|marginal value theorem|parasitoid insects|patch decision rules"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88637,"idioma_id":5,"titulo":"ENFOQUE BAYESIANO PARA LA INVERSIÓN NO PARAMÉTRICA DE MEDICIONES DE DISPERSIÓN DE LUZ","resumen":"Resumen. En este trabajo resolvemos el problema inverso de estimar la Distribución de Tamaño dePartículas (DTP) a partir de mediciones de Dispersión de Luz Estática (DLE) empleando un modeloaproximado denominado Aproximación Local Monodispersa (ALM).La estimación de la DTP es resuelta mediante un esquema de forma libre donde no hay suposición de laforma de la distribución y empleando un enfoque Bayesiano. En trabajos anteriores, se ha empleado unenfoque determinístico con métodos basados en la maximización de la función de máxima verosimilitud.Sin embargo los errores de modelado introducidos por la ALM producen un empobrecimiento en losresultados obtenidos con estos métodos. Los métodos de enfoque Bayesiano ofrecen una interesantealternativa donde es posible incluir información adicional para obtener una mejora en las estimacionesasí como un cálculo de los intervalos de confianza. El Método Iterativo Bayesiano (MIB) que sedesarrolla aquí está basado en el algoritmo Metropolis-Hastings y ha sido testeado con simulacionesnuméricas y validado mediante mediciones experimentales. En este trabajo, la información adicionalutilizada proviene de una técnica experimental alternativa, denominada Microscopía Electrónica deBarrido (MEB). Los resultados hallados son comparados con los publicados en un trabajo anterior(Otero y col., J. of Polymer Science Part B: Polymer Physics, 48(9), 958-963 (2010))","palabras_clave":"PROBLEMA INVERSO|DISTRIBUCIÓN DE TAMAÑOS DE PARTICULAS|MÉTODOS BAYESIANOS|ESTIMACIÓN NO PARAMÉTRICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88638,"idioma_id":4,"titulo":"Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity","resumen":"The hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia and renal dysfunction. The typical form of HUS is generally associated with infections by Gram-negative Shiga toxin (Stx)-producing Escherichia coli (STEC). Endothelial dysfunction induced by Stx is central, but bacterial lipopolysaccharide (LPS) and neutrophils (PMN)  contribute to the pathophysiology. Although renal failure is characteristic of this syndrome, neurological complications  occur in severe cases and is usually associated with death. Impaired blood-brain barrier (BBB) is associated with damage to cerebral endothelial cells (ECs) that comprise the BBB. Astrocytes (ASTs) are inflammatory cells in the brain and determine the BBB function. ASTs are in close proximity to ECs, hence the study of the effects of Stx1 and LPS on ASTs, and the  influence of their response on ECs is essential. We have previously demonstrated that Stx1 and LPS induced activation of rat ASTs and the release of inflammatory factors such as TNF-a, nitric oxide and chemokines. Here, we demonstrate that rat ASTs-derived factors alter permeability of ECs with brain properties (HUVECd); suggesting that functional properties of BBB could also be affected. Additionally, these factors activate HUVECd and render them into a proagregant state promoting PMN and platelets adhesion. Moreover, these effects were dependent on ASTs secreted-TNF-a. Stx1 and LPS-induced ASTs response could influence brain ECs integrity and BBB function once Stx and factors associated to the STEC infection reach the brain parenchyma and therefore contribute to the development of the neuropathology observed in HUS.","palabras_clave":"Stx|LPS|ASTROCYTES|ENDOTHELIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88639,"idioma_id":4,"titulo":"CO preferential oxidation on cordierite monoliths coated with Co\/CeO2 catalysts","resumen":"Cordierite monoliths washcoated with Co\/CeO2 catalysts prepared from different methods were studied for theCOpreferential oxidation reaction. Powder catalystswere also studied for the sake of comparison and in order to select the best formulations to prepare the catalytic coatings. High -Co loaded catalysts resulted in good CO conversions and they showed Co3O4 as the main cobalt containing phase. Consequently, three cordierite e washcoated catalysts were prepared with high Co loadings (c a. 10wt. % of Co in the catalytic layer). C1 and C2 were obtained by CeO2 washcoating followed by cobalt impregnation. In the first case, Ce oxide particles were obtained from a nitrate solution and in the second, a Nyacol suspension was used. A third sample was prepared (C3) using a slurry of a co-precipitated Co10(CP) catalyst. Monolith C3 showed the best CO conversion, although the difference with the other catalysts was not so evident as theone observed for the powder formulations.Themechanical stability, measured by ultrasound tests, was good for all monolithic catalysts and monolith C1 showed no-deactivation after 100 h of time-on-stream at 190 C. The structured catalysts prepared were characterized by XRD, TPR, LRS, SEM and XPS, showing that their physical-chemistry features depend on the preparation method and Co loading.","palabras_clave":"Co\/CeO2|Monolithic catalysts|CO preferential oxidation|Co3O4"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88640,"idioma_id":4,"titulo":"Oceanic influence on southernmost South American precipitation","resumen":"The potential oceanic influence on southernmost  South American precipitation since 1930 is analyzed in this paper. The aim is  to define oceanic characteristics that can produce wetter or drier conditions  over the mentioned region in different time scales. Results suggest important  precipitation-oceanic links in decadal and interdecadal oscillations. The  eastern and central subtropical Indian, western tropical Pacific and western  and central subtropical Pacific could be forcing the precipitation in decadal time  scale. Moreover, the eastern tropical and western subtropical Indian and  western and central subtropical Pacific could be forcing the variability of  precipitation in interdecadal time scale. Although the research was focused in  forcing of precipitation, relations among different regions of the Indian and  Pacific oceans in decadal and interdecadal time scales have also been detected.  Therefore, results here presented can be useful in discovering new aspects of  the remote influence of both oceans on regional climate.","palabras_clave":"PATAGONIA|PRECIPITATION VARIABILITY|DECADAL OSCILLATIONS|WAVELET ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88641,"idioma_id":4,"titulo":"Eastern Patagonia seasonal precipitation: influence of Southern Hemisphere circulation  and links with subtropical South American precipitation","resumen":"Some aspects of the seasonal precipitation overEastern Patagonia, the southernmost area of South Americaeast of the Andes Cordillera, are examined in this paper. Results indicate thatthe central-north areas, the southern continental region and the southernmostislands are three independent regions of seasonal precipitation and that eachof them is associated with specific patterns of atmospheric circulation.Precipitation over the central-north region is significantly related to theprecipitation over a wide area of southern South America east of the Andes during the four seasons. Enhanced (reduced)precipitation over this area is associated with weakened (intensified) westerlyflow in the region. Precipitation over the southern continental area has closeconnection with the dipolar pattern of precipitation over subtropical South America during spring, summer and autumn. Theanomalies of atmospheric circulation at low and upper levels associated withthe subtropical dipole are also able to modulate the intensity of thewesterlies over the south of Eastern Patagoniaaffecting the regional precipitation. Precipitation over the islands of thesouthernmost part of Eastern Patagonia isconnected with subtropical precipitation in summer and winter. The activity offrontal systems associated with migratory perturbations moving to the eastalong the Southern Hemisphere storm tracks modulates the variability ofseasonal precipitation over this region.","palabras_clave":"PATAGONIA|SOUTH AMERICAN PRECIPITATION|SOUTHERN HEMISPHERE CIRCULATION|WESTERLY WINDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88642,"idioma_id":4,"titulo":"Angiopoietins\/TIE2 system and VEGF are involved in ovarian function in a DHEA rat model of polycystic ovary syndrome","resumen":"Polycystic ovary syndrome (PCOS) is the most common endocrinological pathology among women of reproductive age. It is characterized by anovulation, oligo- or amenorrhea, hyperandrogenism, obesity, and insulin resistance. PCOS patients present with elevated levels of vascular endothelial growth factor (VEGF) in serum and follicular fluid. In this study, we examined the ovarian expression of angiopoietins (ANGPT) and their receptor tyrosine kinase receptor (TIE2), involved in the stabilization of blood vessels, in a rat model of dehydroepiandrosterone-induced PCOS. We also analyzed the effect of ovarian VEGF inhibition on ANGPT\/TIE2, follicular development, and vascular stability. VEGF levels were increased in the PCOS ovaries, whereas the levels of its receptor fetal liver kinase-1 were decreased. In addition, the periendothelial cell area and the ANGPT1 to ANGPT2 ratio in the ovary were increased in the PCOS group. Percentage of primary follicles was increased and the percentage of preantral follicles and corpora lutea was decreased in the PCOS group. VEGF inhibition decreased the percentage of primary follicles close to control values. Interestingly, despite the presence of cysts in the ovaries from VEGF inhibitor-treated PCOS rats, its percentage was lower than the PCOS group without treatment. In summary, this study describes an alteration not only in the VEGF\/fetal liver kinase-1 system but also in the ANGPT\/TIE2 system in a dehydroepiandrosterone-induced PCOS rat model. This leads to an increase in periendothelial cell recruitment. We also demonstrated that ovarian VEGF inhibition can partially restore the accumulation of small follicles in PCOS rats and reduces cyst formation, improving ovulation and follicular development. Therefore, the inhibition of VEGF could be considered, in addition to other currently applied treatments, as a new strategy to be studied in PCOS patients to restore ovarian function.","palabras_clave":"ANGIOPOIETINS|TIE2|VEGF|PCOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88643,"idioma_id":4,"titulo":"Pelecitus tercostatus (Molin, 1960) (Nematoda: Onchocercidae) in Amazona vinacea (Aves: Pssitaciformes) from Argentina: morphological details and clinical findings","resumen":"Pelecitus tercostatus (Molin, 1860) (Onchocercidae, Dirofilariine) was found in the leg of a Vinaceous-breasted Parrot Amazona vinacea (Aves, Psittaciformes) from Misiones, Argentina. The present report enlarges the host distribution of the species and represents the first record of any nematode in A. vinacea. The macroscopic lesions produced in the bird are also described.","palabras_clave":"Pelecitus|Onchocercidae|Amazona vinazea|Pssitacidae|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88644,"idioma_id":4,"titulo":"Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of rhesus macaque","resumen":"BACKGROUND In non-primates, the epidermal growth factor (EGF) and EGF-related ligands such as amphiregulin (AREG) serve as critical intermediates between the theca\/mural cells and the cumulus-oocyte-complex (COC) following the mid-cycle LH surge. Studies were designed in primates (1) to analyze AREG levels in follicular fluid (follicular fluid) obtained from pre-ovulatory follicles, as well as (2) to assess dose-dependent effects of AREG on oocytes from small antral follicles (SAFs) during culture, including meiotic and cytoplasmic maturation. METHODS Controlled ovulation protocols were performed on rhesus monkeys (n = 12) to determine AREG content within the single, naturally selected dominant follicle after an ovulatory stimulus. Using healthy COCs (n = 271) obtained from SAFs during spontaneous cycles (n = 27), in vitro maturation (IVM) was performed in the absence or presence of physiological concentrations of AREG (10 or 100 ng\/ml) with or without gonadotrophins (FSH, 75 mIU\/ml; LH, 75 mIU\/ml). At the end of the culture period, oocyte meiotic maturation was evaluated and ICSI was performed (n = 111), from which fertilization and early embryo development was followed in vitro. RESULTS AREG levels in follicular fluid from pre-ovulatory follicles increased (P","palabras_clave":"OOCYTE MATURATION|AMPHIREGULIN|RHESUS MONKEYS|SMALL ANTRAL FOLLICLE|EMBRYO DEVELOPMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88645,"idioma_id":4,"titulo":"Description of Maritrema formicae n. sp. (Digenea: Microphallidae) parasitic in the Kelp Gull, Larus dominicanus, from the Patagonian coast, Argentina","resumen":"Maritrema formicae sp. nov. is described from the Patagonian coast, Argentina, based on adults obtained from the kelp gull, Larus dominicanus. The new species fits with the ?eroliae complex? and can be distinguished from other related species mainly in shape and size of body, shape, size, and pattern of distribution of cirrus spines, uterus extension, number and size of eggs, vitellarium in a complete ring in all specimens, and its Neotropical distribution. The new species is sympatric with another species of the genus, Maritrema madrynense, which was recorded in the same host and locality.","palabras_clave":"TREMATODE DIGENEANS|MARITREMA|MICROPHALLIDAE|LARUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88646,"idioma_id":4,"titulo":"Photometric distances to young stars in the inner galactic d isk II. The region towards the open cluster Trumpler 27 at L = 355 o","resumen":"Context. The spiral structure of the Milky Way inside the solar circleis still poorly known because of the high density of the material thatcauses strong extinction towards the Galactic center.  Aims: Wepresent results of the first extensive and deep color-color diagram(CCD) photometric survey carried out in the field of the open clusterTrumpler 27, an object immersed in a region of extremely high visualabsorption in the constellation of Sagittarius not far from the Galaxycenter. The survey covers almost a quarter of square degree. Methods: We look for young stars clumps that might plausibly beassociated with spiral structure. Wide-field UBVI photometry combinedwith infrared information allows us to reconstruct the distribution inthe reddening and distance of young stars in the field using the CCD andcolor-magnitude diagrams (CMD).  Results: The analysis of ourdata, combined with extensive spectroscopy taken from the literature,shows that the real entity of Trumpler 27 as an open cluster is far frombeing firmly stated. In fact, instead of finding a relatively compactgroup of stars confined to a small distance range, we found that starsassociated with Trumpler 27 are, indeed, a superposition of early-typestars seen along the line of sight extending over several kiloparsecsbeyond even the center of the Galaxy. We demonstrate that at eachdistance range it becomes possible to generate a CMD resembling that ofan open cluster. This way, our analysis indicates that what wasconsidered an open cluster characterized by a significant age spread isa stellar continuum that reaches its maximum number of stars atapproximately 3.5 kpc from the Sun, the distance of the Scutum-Crux armapproximately. After analyzing the way early-type stars distribute withdistance, we found that some of these stellar groups may be linked,within the distance errors, with other inner spiral arms of our Galaxy,including the Near 3 kpc arm at approximately 5 kpc from the Sun.However, very young stars by themselves do not seem to trace stronglythe inner spiral arms since they are distributed evenly across severalkiloparsecs toward the center of the Galaxy. This is remarkablydifferent to current HI and CO radio observation maps, which show innerspiral arms composed by discrete structures of gas with a well-definedinter-arm separation.","palabras_clave":"Galaxy: disk|open clusters and associations: general|open clusters and associations: individual: Trumpler 27|stars: early-type, Galaxy: structure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88647,"idioma_id":4,"titulo":"A new ADAMTS13 missense mutation (D1362V) in thrombotic thrombocytopenic purpura diagnosed during pregnancy","resumen":"Thrombotic thrombocytopenic purpura (TTP) is a disease characterized by microvascular thrombosis, often associated with deficiency of ADAMTS13 activity. Hereditary TTP has been linked to mutations in the ADAMTS13 gene whereas the inhibition of ADAMTS13 activity by autoimmune antibodies has been associated with acquired TTP. We report the case of a woman with deficiency of ADAMTS13 activity that had been asymptomatic until her first severe TTP episode during her first pregnancy. Genetic analysis revealed a non described missense mutation of ADAMTS13. This mutation resulted in an aspartic acid to valine substitution (D1362V). To verify the mechanism of ADAMTS13 deficiency in this patient, the wild type and the D1362V ADAMTS13 mutant construct was expressed in HEK 293 cells. The D1362V substitution led to a defect of secretion (ADAMTS13 antigen level=8±3%, ADAMTS13 activity=0% in culture media), causing intracellular accumulation of the protease (ADAMTS13 antigen level=133±5%, ADAMTS13 activity=129±13%) compared to wild-type (WT) ADAMTS13 (ADAMTS13 antigen and activity=100%). The results showed that D1362V mutation in the second CUB (CUB-2) domain, encoded by exon 29, induces an ADAMTS13 plasmatic deficiency due to reduced secretion of the protease into the circulation. Our data suggested that the CUB-2 domain encoded by exon 29 is particularly important for ADAMTS13 secretion. Apparently, this severe ADAMTS13 plasmatic deficiency did not manage to lead to clinical manifestations given that the TTP triggering event was related to her first pregnancy.","palabras_clave":"THROMBOTIC THROMBOCYTOPENIC PURPURA|ADAMTS13|PREGNANCY|CUB-2 DOMAIN|SITE-DIRECTED MUTAGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88648,"idioma_id":4,"titulo":"Von Willebrand factor (VWF) as a risk factor for bleeding and thrombosis","resumen":"The von Willebrand factor (VWF) is analysed as a bleeding and thrombotic risk marker. When the VWF level is increased, it predicts a thrombotic phenotype and when VWF level is low in plasma, the phenotype varies to bleeding disorder. But it is quite challenging to define when the level is low, normal or high taking into account that these values are capricious and overlap. This matter should be solved by extensive epidemiologic studies. VWD is a hereditary disorder with several described mutations. VWF is a major acute-phase reactant, besides the physiological conditions such as blood group and pregnancy that affect plasmatic VWF levels. Subjects with O blood group have 25% less VWF than those of non O blood groups, and the latter show higher thrombus burden. VWF would be sensitive though not specific diagnostic marker of myocardial infarction. For the assessment of bleeding severity there are special surveys, scores and pictorial charts. The identification of VWF as a thrombotic risk marker has not been clearly established yet, but it has been involved in stroke and coronary disease. We only have the specific replacement therapy for the bleeding phenotype and we can speculate that enoxaparin and PEG-hirudin are able to blunt the VWF rise in patients with unstable angina pectoris and it is associated with a more favourable clinical outcome.Only two questions remain: does VWF as a bleeding risk marker have the same value as a thrombotic risk marker? Will successful treatments like those achieved for bleeding be also possible in the future for thrombosis?","palabras_clave":"VON WILLEBRAND FACTOR|BLEEDING|THROMBOSIS|RISK FACTORS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88649,"idioma_id":5,"titulo":"Estudio preliminar sobre la circulación del virus de influenza canina en Buenos Aires","resumen":"El virus de la  influenza canina ha sido recientemente descripto, asociado a cuadros  respiratorios en caninos. El virus está altamente emparentado con el virus de  influenza equina H3N8. Existe evidencia que el virus ha estado circulando en la  población canina mucho antes del primer brote descripto en el 2004 en Florida,  USA. Asimismo, existen registros de infecciones en caninos con virus de  influenza aviar (H3N2) y con el H1N1 pandémico, a partir de dueños infectados.  El diagnóstico puede hacerse por aislamiento o detección del agente por PCR  (Polymerase Chain Reaction). Sin embargo, el corto tiempo en que el virus puede  ser detectado hace la detección de anticuerpos la técnica más apropiada.        En la cátedra de  Virología de la UBA se desarrolló un test de inhibición de hemaglutinación para  determinar la presencia de anticuerpos contra este virus en caninos del área  metropolitana de Buenos Aires. Mediante un muestreo no aleatorio de animales  que concurrieron al Hospital Veterinario de la Facultad de Ciencias  Veterinarias de la UBA y animales de refugios se determinó la ausencia de  anticuerpos contra el virus de influenza H3N8 en los caninos testeados. Este  estudio preliminar sugeriría que por el momento no existe evidencia de la  circulación de este virus en la población canina local.        &nbsp;","palabras_clave":"influenza canina|influenza equina|H3N8"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88650,"idioma_id":4,"titulo":"An alternative model for the early peopling of southern South America revealed by analyses of three geographically linked mitochondrial DNA haplogroups","resumen":"After several years of research, there is now a consensus that America was populated from Asia through Beringia, probably at the end of the Pleistocene. &nbsp;But many details such as the timing, route(s), and origin of the first settlers remain uncertain.&nbsp; In the last decade genetic evidence has taken on a major role in elucidating the peopling of the Americas. &nbsp;&nbsp;&nbsp;&nbsp; To study the early peopling of South America, we sequenced the control region of mitochondrial DNA from 300 individuals belonging to indigenous populations of Chile and Argentina, and also obtained seven complete mitochondrial DNA sequences. &nbsp;&nbsp;&nbsp;&nbsp; We identified two novel mtDNA monophyletic clades, preliminarily designated B2l and C1b13, which together with the recently described D1g sub-haplogroup have locally high frequencies and are basically restricted to populations from the extreme south of South America.&nbsp; The estimated ages of D1g and B2l, about ~15,000 years BP, together with their similar population dynamics and the high haplotype diversity shown by the networks, suggests that they probably appeared soon after the arrival of the first settlers and agrees with the dating of the earliest archaeological sites in South America (Monte Verde, Chile, 14,500 BP).&nbsp; One further sub-haplogroup, D4h3a5, appears to be restricted to Fuegian-Patagonian populations and reinforces our hypothesis of the continuity of the current Patagonian populations with the initial founders. &nbsp;&nbsp;&nbsp;&nbsp; Our results indicate that the extant native populations inhabiting South Chile and Argentina are a group which had a common origin, and suggest a population break between the extreme south of South America and the more northern part of the continent.&nbsp; Thus the early colonization process was not just an expansion from north to south, but also included movements across the Andes. ","palabras_clave":"MITOCHONDRIAL DNA|NATIVE AMERICANS|HAPLOGROUP|HAPLOTYPES|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88651,"idioma_id":4,"titulo":"Mineralogy and geochemistry of hydrothermal kaolins from the Adelita mine, Patagonia (Argentina)","resumen":"The kaolin deposit Adelita mine, located in the province of Río Negro(Patagonia, Argentina), was studied. Petrographic studies on thin sections and chemical analyses of major, minor and trace elements on bulk samples were carried out. The kaolin content in the rock ranges from 31% to 65%. The mineralogy of the working face, which is about 45 m thick, varies from the upper zone, where the rock is strongly silicified, stained with iron oxides and carbonated, grades downwards to a kaolinized zone, with a quartz-kaolinite-dickite assemblage with relict lithic particles and a smaller amount of iron oxides, to end in the deepest zone where dickite, alunite, diaspore, quartz and scarce associated kaolinite occur. Kaolin mineralogy was determined by SEM, XRD, DTA-TG, IR and &#61540;18O and &#61540;D isotope analyses. Trace element content, the relationships Zr vs. Ti, Cr + Nb vs. Ti + Fe, and Ce + Y + La vs. Ba + Sr, chondrite-normalized rare earth element diagrams showing a marked enrichment in LREE relative to HREE, with negative europium anomalies and d18O and dD between 3.8%0 and 7.7%0 and -123%0 and -103 %0, respectively, suggest that kaolin formed from the hydrothermal alteration of rhyolitic tuffs. ","palabras_clave":"GEOCHEMISTRY|MINERALOGY|KAOLIN DEPOSITS|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88652,"idioma_id":4,"titulo":"Effects of Capture, Shearing and Release on the Ecology and Behavior of Wild Vicuñas","resumen":"ABSTRACT The goals of sustainable use of wildlife include minimizing long term deleterious impacts of management. We evaluated the ethoecological and demographic responses of wild vicunas (Vicugna vicugna) to capture, shearing, and release in northern Argentina, as well as effects on behavior, by comparing captured and shorn versus non-captured animals for 2 yr after capture events. We observed subtle and short-term changes in the movement behavior of individuals, likely due to thermal and behavioral stress following  capture. We did not observe changes in survival and birth rates, social organization, or distribution of animals following capture. Therefore, we concluded that the capture techniques used resulted in low impacts on the  wild vicuna population.  2011 The Wildlife Society.","palabras_clave":"VICUÑAS|CAPTURA|ESTRES|MANEJO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88653,"idioma_id":5,"titulo":"USO DEL HÁBITAT POR VICUÑAS (Vicugna vicugna) EN UN SISTEMA AGROPASTORIL EN SURIPUJIO, JUJUY","resumen":"La vicuña es un camélido silvestre que comparte con los otros camélidos del altiplano un rol clave en ese ecosistema y un alto valor cultural en la cosmovisión de los pueblos andinos. Suripujio (Jujuy) es una zona donde se practica una economía de subsistencia basada en el pastoreo de ovejas y llamas y donde las vicuñas conviven con el ganado (llamas y ovejas) y con burros asilvestrados.   El objetivo del presente trabajo fue analizar cambios espaciales y temporales en el uso del hábitat de las vicuñas y el ganado doméstico, en relación a la oferta de recursos en el área de Suripujio, provincia de Jujuy, Argentina.  Se determinó la oferta de recursos forrajeros y su variación temporal, analizando el tamaño, la variación en el espacio, la cobertura y composición de cada unidad de vegetación, y los cambios espaciales y temporales en el uso del hábitat de los herbívoros bajo estudio.   Los resultados mostraron que en la temporada húmeda aumentó la oferta forrajera, del estrato bajo tanto en vegas como en estepas arbustivas. En las estepas arbustivas, las cargas animales sobrepasaron la capacidad de carga definida para ese ambiente; y se registró una segregación espacial entre las vicuñas y el ganado doméstico, mientras que la vega fue un ambiente seleccionado tanto por las vicuñas como por el ganado.   El manejo ganadero revela carencias que disminuyen la potencial productividad de este ecosistema, que muestra potencialidad para un posible manejo de las vicuñas.","palabras_clave":"ALTIPLANO|CONSERVACIÓN|CAMÉLIDOS SUDAMERICANOS|CAPACIDAD DE CARGA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88654,"idioma_id":4,"titulo":"Sexual dimorphism in Leptodactylus latinasus (Anura, Leptodactylidae): nasal capsule anatomy,morphometric characters and performance associated with burrowing behavior","resumen":"In anurans, the ability to burrow has been associated with the characteristics ofexternal morphology, with modifications in the musculoskeletal system and evenin some brain regions. Male Leptodactylus fuscus construct subterranean chamberswith the snout, where the eggs are deposited and early larval stages develop.Leptodactylus latinasus, a member of the L. fuscus group, is a good model to testthe relationship among digging behavior of males, sexual divergence in the morphologyof the nasal region, cranial-dimensions, and performance as digger. Thegoal of this work is to provide a detailed morphological description of the olfactoryregion, which allows detecting sexually dimorphic characters, to evaluatesexual divergence with head dimension data, and to test whether differences existin the digging performance of each sex. Our data do not clearly indicate sexualdimorphism in head size, nasal region morphology or digging performance thatcan be linked with the burrowing behavior. Thus, the only unequivocal sexuallydimorphic character associated with the construction of the nuptial chamber bymales would be the rigid, chisel-like snout, present exclusively in males.","palabras_clave":"HEAD SHAPE|DIGGING FORCE|LEPTODACTYLUS|NASAL CAPSULE|SEXUAL DIMORPHISM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88655,"idioma_id":4,"titulo":"Postnatal ontogenetic scaling of nesodontine (Notungulata, Toxodontidae) cranial morphology","resumen":"Toxodontidae is a clade of endemic South American ungulates that comprises medium to very large animals, including strict megammamals, i.e., 1000 kg or more. Adinotherium at approximately 120 kg and Nesodon at 550 kg are respectively the smallest and the largest Nesodontinae of Santacrucian age (early Miocene). The large number of specimens recorded and the quality of preservation (including very young animals) permit a morphometric study of cranial ontogeny. We measured 17 cranial variables on an ontogenetic series of 23 specimens of A. ovinum and 11 of N. imbricatus. Bivariate analysis (Standardized Major Axis) was performed in order to obtain the coefficients of allometry using skull length as the independent variable. Results indicate that eight of 16 variables show an isometric trend, seven exhibit positive allometry, and only the height of the orbit in N. imbricatus exhibits negative allometry. Contrary to expectation, neurocranial variables are positively allometric or isometric. With respect to the splanchnocranium, most variables related to the rostrum, palate, and masticatory muscles show positive allometry suggesting a strengthening of masticatory system in adults of both taxa. The splanchnocranial allometric trends fail to support previous inferences of specialized herbivory, suggesting generalized herbivory in nesodontines.","palabras_clave":"Adinotherium|allometry|Nesodon|masticatory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88656,"idioma_id":4,"titulo":"Body Mass estimation in Early Miocene native South American Ungulates: a predictive equation based on 3D landmarks","resumen":"South American native ungulates include extinct taxa that evolved within thegeographical context given by the isolation of South America during most of the Cenozoic. The ungulates (orders Notoungulata, Litopterna and Astrapotheria) of the Santa Cruz Formation (late Early Miocene) are particularly interesting for paleobiological studies due to their diversity, richness and quality of preservation of the specimens. The body mass estimation of extinct species is one of the basic biological attributes for paleobiological reconstructions. The most common way to estimate body mass from fossils is using linear regression. Here, we used geometric morphometric techniques in order to estimate their body mass. We usedregressions based on centroid size of 3D craniomandibular landmark configurations, including extant ungulates (their size and ecological relatives). Cases were weighted to maximize the taxonomic evenness. A broad body size range was recorded. The highest predictive power is obtained with those functions derived from the highest taxonomic and ecological diversity. The highest taxonomic richness corresponds to masses below 100 kg. Among Notoungulata, typotheres (Hegetotheriidae + Interatheriidae) vary from 1 to less than 10 kg, while the smaller toxodontid reached 100 kg and the larger 500 kg. Litoptern proterotheriid body masses vary from 10 to 50 kg, and macraucheniids surpass 100 kg. The astrapotheres (Astrapotheria) reached (or even surpassed) 1000 kg, being the only megamammal in the Santacrucian ungulate assemblage.","palabras_clave":"NATIVE UNGULATES|MIOCENE|SANTACRUCIAN|BODY MASS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88657,"idioma_id":4,"titulo":"The forelimb of Early Miocene sloths (Mammalia, Xenarthra, Folivora): morphometrics and functional implications for substrate preferences","resumen":"Early Miocene sloths are represented by a diversity of forms ranging from 38 to 95 kg. Their forelimb bones differ in shape from those of their closest living relatives (of approximately 10 kg), Bradypus and Choloepus. Such difference in shape could be related to differences in substrate preference (arboreal, semiarboreal, or ground-dwelling) or substrate use (climbing, digging, etc.). In order to detect putative patterns related to substrate preference, 21 linear measurements were defined and taken on the forelimb bones. The sample was composed of 22 specimens of fossil sloths and 134 specimens of extant mammals (marsupials, xenarthrans, pangolins, rodents, primates, and carnivorans), including arboreal, semiarboreal, and ground-dwelling taxa. Principal Components Analyses were performed on logarithms of original measurements, while functional indexes (Index of Fossorial Ability, Brachial Index, and Distal Epiphyseal Index) were calculated on raw data. The first three PCs accounted for 93.8 % of the cumulative variability. PC1 roughly represented size, while positive values of PC2 represented mechanical advantage for features related to digging habits. Fossil sloths were clearly separated from living ones, sharing a common morphospace with anteaters and other good diggers. Conversely, living sloths shared a morphospace with primates. Similar results were obtained for DEI and IFA, with fossil sloths showing similar values to extant digging mammals. These results suggest that fossil sloths have a different functional pattern of forelimb use than that of extant ones, probably more similar to vermilinguas and pangolins, including putative good digging capabilities and\/or semiarboreal habits. Substrate use seems to be interfering in the analysis of substrate preference based on forelimb morphology.","palabras_clave":"Miocene sloths|morphometry|substrate preference|substrate use"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88658,"idioma_id":4,"titulo":"Distribution of extant xenarthrans (Mammalia: Xenarthra) in Argentina using species distribution models","resumen":"The xenarthrans are the only group of mammals that originated in South America; there are 31 living species: six sloths, four anteaters, and 21 armadillos. In Argentina, 18 species of xenarthrans were cited. The objectives of this study were to compile the existing information on the distribution of the xenarthrans of Argentina, to use species distribution models to map the potential distribution of these species, and to assess patterns of species richness of this important group of mammals. We obtained a total of 975 records corresponding to 706 different collecting localities from Argentina. We generated species distribution models for 15 of the 18 species present in the country. Virtually all of Argentina is occupied by xenarthrans. The highest richness of species is in the north and northeast of the country in the humid and arid Chaco, probably in relation with the mosaic of ecosystems recorded in these regions. These ecoregions have different degrees of habitat degradation and continues to be a major threat for the viability of the xenarthrans occurring there. The information given in this contribution is an input to clarify occurrence and distribution of this group of mammals.","palabras_clave":"anteaters|armadillos|sloths|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88659,"idioma_id":4,"titulo":"Effect of temperature and chloride concentration on the anodic behavior of nickel alloys in bicarbonate solutions","resumen":"It has been shown that the presence of bicarbonate ions and chloride is necessary to produce stress corrosion cracking (SCC) in alloy 22 at anodic applied potentials. It has been suggested that the susceptibility to SCC could be related to the occurrence of an anodic peak in the polarization curves below the transpassive rangeThe aim of this work is to study the anodic behavior of alloy 22 and other nickel alloys in different media containing bicarbonate ions and chloride in various concentrations and temperatures to determine if there is a correlation between the presence of the anodic peak and the occurrence of SCC; and to determine which element in the alloy maybe be responsible for the cracking. The studied alloys included alloy 22, Ni-200, alloy 800 and alloy 600. Results show that in general the potential and the peak current increased with temperature and chloride concentration in the solution. For the alloys with the smaller alloying content the peak potential decreased to the point of disappearing. There was no dependence of the current peak with the amount of alloying.","palabras_clave":"NICKEL ALLOYS|N06022|CORROSION|BICARBONATE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88660,"idioma_id":4,"titulo":"Protective effect of low UVA irradiation against the action of lethal UVA on Pseudomonas aeruginosa: Role of the relA gene","resumen":"The exposure of Pseudomonas aeruginosa cells to very low UVA fluences induces a growth delay, a phenomenonproposed in Escherichia coli as an adaptive mechanism related to protection against lethaland mutagenic effects of UVA. This paper reports that the treatment with low UVA irradiation fluencesprotects P. aeruginosa PAO1 strain from a subsequent lethal exposure. This phenomenon depends onthe relA gene, coding for the main (p)ppGpp synthetase, and is unrelated to the induction of quorum sensingor catalase activity, two essential factors involved in the response of P. aeruginosa to UVA. Crossprotectionbetween osmotic stress and UVA is observed when a great protective response to lethalUVA is caused by the induction of resistance to osmotic stress. The increase in resistance to osmotic shockobserved in the pre-irradiated PAO1 strain but not in its relA derivative, unable to show photo-protection,leads us to hypothesize that the photo-protection could be attributed to an adaptive response to osmoticstress. It is concluded that the exposure of P. aeruginosa to low UVA doses induces a relA-dependent adaptiveresponse that protects against cell death induced by high doses and causes an increase in the resistanceto osmotic stress.","palabras_clave":"Pseudomonas  | relA| Stringent response|Ultraviolet-A"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88661,"idioma_id":4,"titulo":"Model predictive control for induction motor control reconfiguration after inverter faults","resumen":"This work analyzes the use of model predictive control (MPC) for induction motor (IM) control and compares it with the standard form of the direct torque and flux control (DTFC) strategy. These two strategies are fundamentally different in operation since (i) MPC decides the current control action by on-line minimization of a cost function that uses the available inverter output voltages as optimization variables, whereas (ii) DTFC decides the current control action based on a switching table constructed using a simplified model of the IM. Emphasis is given in this work to the reconfiguration of the control action after voltage source inverter faults. We assume that the fault can be suitably detected and isolated and that the inverter can be reconfigured after the specific fault to continue operation, albeit with a reduced set of achievable output vectors. Based on this reduced set of vectors, we propose to reconfigure the induction motor control algorithm by (i) providing the reduced set of inverter vectors as the reconfigured constraint set of optimization variables for MPC or (ii) instructing DTFC to use a reconfigured switching table. Simulation results show that MPC with prediction horizon N = 1 considerably outperforms DTFC at a modest increment of computational cost. Moreover, this increment is less pronounced under fault since the number of optimization variables is reduced.","palabras_clave":"MODEL PREDICTIVE CONTROL|CONTROLLER RECONFIGURATION|DIRECT TORQUE AND FLUX CONTROL|INDUCTION MOTOR|INVERTER FAULTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88662,"idioma_id":4,"titulo":"A neomorphic ossification of the nasal cartilages and the structure of paranasal sinus system of the glyptodont Neosclerocalyptus Paula Couto 1957 (Mammalia, Xenarthra)","resumen":"Glyptodonts together witharmadillos, pampatheres and peltephilines constitute the Cingulata, one of the three clades of the Xenarthra. The most remarkable feature of this group is the presence of an armored exoskeleton along the head, body and tail. Only a few contributions have described in detail the endoskeleton. In the case of the skull, almost no attention has been focused on the narial region. The objective of this study is to provide a description of the narial anatomy of the glyptodont Neosclerocalyptus. This genus has the most expanded andglobular narial region among glyptodonts and was recently described as partof the fronto-nasalsinuses system. Our analysis based on CT scanning shows that this region includes an independent ossification of the nasal cartilage that housed the maxillo-atrioturbinates. Thisossification would represent a neomorphic feature producedby a terminal addition of an ossified stage via peramorphosis. Other remarkable anatomical features are the presence of an expanded paranasal sinuses system that involves the nasal, frontal, parietal and squamosal bones, and the wide separation between the maxillo-atrioturbinates and ethmoturbinates. Functional consequences of this rearrangement are not readily predicted or inferred. Thus, this neomorphic ossification would constitute a morphological novelty, but not necessarily a functional one.","palabras_clave":"cingulates|glyptodonts|nasal cavity|narial ossification|neomorphic|function"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88663,"idioma_id":4,"titulo":"Characterization of cell wall polysaccharides of the coencocytic green seaweed Bryopsis plumosa (Bryopsidaceae, Chlorophyta) from the Argentine coast","resumen":"Bryopsis sp. from a restricted area of the rocky shore of Mar del Plata (Argentina) on the Atlantic coast was identified as Bryopsis plumosa(Hudson) C. Agardh (Bryopsidales, Chlorophyta) based on morphological characters and rbcL and tufA DNA barcodes. To analyze the cell wall polysaccharides of this seaweed, the major room temperature (B1) and 90°C (X1) water extracts were studied. By linkage analysis and NMR spectroscopy, the structure of a sulfated galactan was determined, and putative sulfated rhamnan structures and furanosidic nonsulfated arabinan structures were also found. By anion exchange chromatography of X1, a fraction (F4), comprising a sulfated galactan as major structure was isolated. Structural analysis showed a linear backbone constituted of 3-linked &#946;-D-galactose units, partially sulfated on C-6 and partially substituted with pyruvic acid forming an acetal linked to O-4 and O-6. This galactan has common structural features with those of green seaweeds of the genus Codium (Bryopsidales, Chlorophyta), but some important differences were also found. This is the first report about the structure of the water-soluble polysaccharides biosynthesized by seaweeds of the genusBryopsis. These sulfated galactans and rhamnans were in situ localized mostly in two layers, one close to the plasma membrane and the other close to the apoplast, leaving a middle amorphous, unstained cell wall zone. In addition, fibrillar polysaccharides, comprising (1&#8594;3)-&#946;-D-xylans and cellulose, were obtained by treatment of the residue from the water extractions with an LiCl\/DMSO solution at high temperature. These polymers were also localized in a bilayer arrangement.","palabras_clave":"CELL WALL|PYRUVYLATED GALACTAN SULFATE|SULFATED POLYSACCHARIDES|GREEN SEAWEED"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88664,"idioma_id":4,"titulo":"Host range of Gonatocerus sp. near tuberculifemur ?Clade 1? in Argentina, an egg parasitoid newly associated to the glassy-winged sharpshooter, Homalodisca vitripennis (Hemiptera: Cicadellidae), and candidate for its biological control in California, USA","resumen":"                                    The South  American egg parasitoid Gonatocerus sp.  near tuberculifemur ?Clade 1? (G. sp. ?Clade 1?) (Mymaridae) is a candidate  to control the north American glassy-winged  sharpshooter, Homalodisca vitripennis (Germar) (Cicadellidae). In Argentina, G. sp. ?Clade 1? was screened in the  laboratory (no-choice test) and in the field (multiple choice tests) against  eggs of 36 hosts.&nbsp; In no-choice assays, it parasitized only eggs  within the tribe Proconiini.&nbsp; In  contrast, in field tests, it emerged not only from Proconiine, but also from  Cicadellini species. Two  interpretations arise from the results: 1) G.  sp.?Clade 1?  is restricted to Proconiini and the field parasitization of Cicadellini species  was a false positive, or 2) G.  sp.?Clade 1 parasitizes also Cicadellini species and the rejection in the lab  was a false negative. &nbsp;Both interpretations are discussed. Insect motivation could be the explanation  for the negative results with the no-choice tests despite being considered very  robust. &nbsp;On the other hand, in the more natural field situation, the  host selection process and oviposition behavior should not have been affected  and results would be more realistic.&nbsp; The  parasitism of Cicadellini species would indicate a potential non-target effect  of sharpshooters  in the US.  The selection of G. sp. ?Clade 1? highly matching the climate  in California  is essential to limit the dispersal of the parasitoid after an eventual field released.  Cost-benefit studies should be conducted to evaluate the potential non target  effect against the current impact of the GWSS.","palabras_clave":"Gonatocerus|Homalodisca|egg parasitoid|non target effects"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88665,"idioma_id":4,"titulo":"Biological control of Tuta absoluta in Argentina and Italy: evaluation of indigenous insects as natural enemies","resumen":"                                    By means of  an international project, Argentinian and Italian researchers are carrying  joint research to study biological and ecological aspects of Tuta absoluta  biological control.This paper lists indigenous natural enemies reported for T.  absoluta, as well as the current results on T. absoluta egg and larval  parasitoids in both countries. Parasitoid species that conformed to different  guilds are shown to coexist in cropping conditions, and some show positive  characteristics as potential biocontrol agents against T. absoluta by means of  augmentative releases. Future laboratory and field evaluations of effective  biological control programmes in Argentina and Italy are proposed.","palabras_clave":"Tomatoes|pest|antagonist|control"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88666,"idioma_id":5,"titulo":"Los complejos metamórficos del retro-arco Famatiniano (noroeste de Argentina): caracterización geoquímica e isotópica de sus protolitos e implicancias geotectónicas","resumen":"Análisis geoquímicos e isotópicos de dos unidades metasedimentarias ordovícicas del retro-arco de la faja orogénica Famatiniana (noroeste argentino), el complejo metamórfico-ígneo El Portezuelo (CMIEP) y el complejo metamórfico La Cébila (CMLC), combinados con estudios geocronológicos previos, muestran que sus protolitos se desarrollaron diacrónicamente en cuencas sedimentarias diferentes. Estudios litológicos y análisis geoquímicos de roca total de elementos mayores y traza permiten determinar que los protolitos de ambos complejos pertenecieron a secuencias de rocas sedimentarias clásticas conformadas principalmente por grauvacas y pelitas. Las metapelitas se caracterizan por tener contenidos mayores en Al2O3, Fe2O3(T), MgO, K2O, TiO2, Rb, Nb, V y Cr, y menores en SiO2, que las metapsamitas. La correlación negativa mostrada en estos elementos con respecto al SiO2 denota la mayor proporción de material arcilloso en las rocas de origen pelítico. Para ambos complejos, las relaciones de Al2O3\/TiO2, La\/Sc, Th\/Sc, La\/Co y Th\/Cr, los patrones de REE, los valores de Cr, Ni y V, y los diagramas geoquímicos La\/Th-Hf, K-Rb y F1-F2 sugieren que los metasedimentos fueron derivados de fuentes félsicas a intermedias. Diversos diagramas geoquímicos de discriminación de ambientes tectónicos indican que los protolitos del CMLC y del CMIEP se relacionarían con ambientes de arco magmático. La mayor variación litológica y geoquímica observada en el CMLC permite inferir un régimen deposicional más inestable que el que habría controlado la sedimentación de los protolitos del CMIEP. Las edades de residencia cortical obtenidas a partir de análisis isotópicos Sm-Nd indican que los protolitos del CMLC (~1,3-1,6 Ga) eran más modernos que los protolitos del CMIEP (~1,8-1,9 Ga). Las variaciones geoquímicas establecidas, los datos isotópicos obtenidos, y los estudios geocronológicos previos, permiten relacionar los protolitos de cada complejo metamórfico a diferentes eventos deposicionales. En este sentido, las posibles rocas precursoras del CMIEP serían las rocas metamórficas pampeanas de bajo grado de la Formación Puncoviscana, mientras que los protolitos del CMLC correspondieron a depósitos sedimentarios de edad Ordovícico Temprano-Medio. El rejuvenecimiento hacia el oeste de los protolitos de los complejos metamórficos del retro-arco Famatiniano como el CMLC es consistente con el desarrollo de cuencas menos estables asociadas a la estructuración del nuevo frente orogénico instalado al oeste sobre el margen de Gondwana.","palabras_clave":"COMPLEJO METAMÓRFICO-ÍGNEO EL PORTEZUELO|COMPLEJO METAMÓRFICO LA CÉBILA|RETRO-ARCO FAMATINIANO|METASEDIMENTOS|GEOQUÍMICA|ISOTOPÍA SM-ND"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88667,"idioma_id":5,"titulo":"Simulación de la Comprensión de Textos Naturales: Implementación del Modelo 'Landscape' en una fábula en español","resumen":"El objetivo de este trabajo fue presentar la implementación del modelo computacional Landscape en un texto narrativo natural en español. El Landscape es un modelo conexionista que concibe la comprensión como un cambiante ?paisaje? de activaciones de proposiciones durante los sucesivos ciclos de lectura. Los picos y valles del paisaje representan la participación relativa de cada proposición en cualquier punto de la historia, y constituyen la base para la representación de ésta. A partir de que el investigador fija sus criterios acerca de qué inferencias son generadas durante la lectura, el programa calcula una matriz de activación on-line y una matriz de aprendizaje off-line. Esta última cuantifica la fuerza de nodo de cada proposición, y el peso de las conexiones entre cada par de proposiciones. Dado que el estudio de la comprensión de textos ha tendido a llevarse a cabo utilizando textos artificiales en inglés como materiales, nos propusimos describir los pasos necesarios para implementar el modelo Landscape en un texto natural en español, a fin de abogar por la utilidad de este modelo para examinar los procesos cognitivos involucrados en la comprensión de textos que no han sido diseñados por los investigadores. * Revista indexada en LATINDEX-CATÁLOGO, IRIESE&nbsp;y en el Portal de Revistas Científicas y Arbitradas de la Universidad Nacional Autónoma de México","palabras_clave":"Simulación|Modelo Landscape de la Comprensión Lectora|Textos Narrativos|Comprensión Lectora"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88668,"idioma_id":5,"titulo":"Comprensión de textos expositivos y métodos sistemáticos de revisión de textos: el efecto del incremento de la densidad de relaciones y la repetición de términos","resumen":"    Los textos expositivos son una importante herramienta    para el aprendizaje. Los métodos que se    proponen mejorar su calidad reciben el nombre de    procedimientos de revisión de textos. El objetivo    de este trabajo fue comparar el efecto de dos métodos    de revisión de textos expositivos: el procedimiento    basado en la repetición de términos y el    procedimiento basado en el incremento de la densidad    de relaciones, en la comprensión de la información    literal del texto y en la generación de inferencias.    Con este fin, 50 estudiantes universitarios    leyeron tres textos expositivos (del área de las    ciencias naturales), y respondieron a una serie de    preguntas acerca del contenido literal del texto y    de la generación de inferencias a partir de él. Los    resultados indicaron que la versión revisada a partir    del procedimiento de incremento de la densidad    de relaciones resultó en un mejor desempeño    que la versión original, y que la versión basada en    el método de repetición de términos. Este resultado    fue observado tanto para las preguntas acerca    del contenido literal el texto como acerca de la generación    de inferencias a partir de él. Los hallazgos    de este estudio sugieren que el método de incremento    de la densidad de relaciones facilita tanto el    establecimiento de vínculos entre las oraciones    contiguas así como entre las oraciones distantes    del texto, promoviendo la construcción de la coherencia    global del texto.","palabras_clave":"Texto Expositivo|Revisión de Textos|Comprensión de Lectura|Generación de Inferencias"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88669,"idioma_id":4,"titulo":"Contribution of a harpin protein from Xanthomonas axonopodis pv. citri to pathogen virulence","resumen":"Xanthomonas axonopodis pv. citri (Xac), the bacterium that causes citrus canker, contains a gene in the hrp [for hypersensitive response (HR) and pathogenicity] cluster that encodes a harpin protein called Hpa1. Hpa1 produced HR in the nonhost plants tobacco, pepper and Arabidopsis, whereas, in the host plant citrus, it elicited a weak defence response with no visible phenotype. Co-infiltrations of Xac with or without the recombinant Hpa1 protein in citrus leaves produced a larger number of cankers in the presence of the protein. To characterize the effect of Hpa1 during the disease, an XacÄhpa1 mutant was constructed, and infiltration of this mutant caused a smaller number of cankers. In addition, the lack of Hpa1 hindered bacterial aggregation both in solution and in&#8201;planta. Analysis of citrus leaves infiltrated with Hpa1 revealed alterations in mesophyll morphology caused by the presence of cavitations and crystal idioblasts, suggesting the binding of the harpin to plant membranes and the elicitation of signalling cascades. Overall, these results suggest that, even though Hpa1 elicits the defence response in nonhost plants and, to a lesser extent, in host plants, its main roles in citrus canker are to alter leaf mesophyll structure and to aggregate bacterial cells, and thus increase virulence and pathogen fitness. We expressed the N-terminal and C-terminal regions and found that, although both regions elicited HR in nonhost plants, only the N-terminal region showed increased virulence and bacterial aggregation, supporting the role of this region of the protein as the main active domain.","palabras_clave":"Xanthomonas axonopodis pv. citri|Hpa1|Arabidopsis thaliana|citrus canker"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88670,"idioma_id":4,"titulo":"Ripening tomato fruit after chilling storage alters protein turn-over","resumen":"BACKGROUND: Tomato fruit is of prime importance owing to its qualities for human nutrition and its economic value. In order to extend its commercial life, it is harvested atmature but unripe stages and stored at low temperatures. The goal of this work was to study the influence of harvest and chilling storage of mature green tomato fruit (cv. Micro-Tom) on the protein pattern, amino acid content and protease activity during fruit ripening.RESULTS: Fruits were sampled during ripening in three different conditions: 1, on the vine; 2, off the vine; 3, off the vine after 4 weeks at 4 degrees Centigrade. During all fruit ripening conditions, protein level decreased while amino acid content increased. Chilling storage of mature green fruit led to a reduction in protein content. Ripening off the vine (conditions 2 and 3) resulted in athreefold increase in red fruit amino acid levels when compared with red fruit on the vine. Protease activities (autoproteolytic, azocaseinolytic and gelatinolytic)were detected in all fruits evaluated andwere differently affected by ripening stage, ripening conditions and the presence of specific inhibitors.CONCLUSION:Harvest and chilling storage increased endogenous substrate proteolysis, azocaseinolytic activity and free amino acid levels, which could be related to fruit quality.","palabras_clave":"PROTEASE|FRUIT|RIPENING|TOMATO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88671,"idioma_id":4,"titulo":"MBF1s regulate ABA-dependent germination of Arabidopsis seeds","resumen":"Transcriptional co-activators of the multiprotein bridging factor 1 (MBF1) controls gene expression by connecting transcription factors and the   basal transcription machinery. In Arabidopsis thaliana functions of MBF1 genes have been related to stress tolerance and developmental   alterations. Endogenous ABA plays a major role in the regulation of   Arabidopsis seed dormancy and germination. Seed dormancy and ABA   sensitivity are enhanced in ethylene insensitive mutants suggesting that   ethylene signal transduction pathway is necessary to fully develop   ABA-dependent germination. In this report we showed that a triple   knock-down mutant for Arabidopsis MBF1 genes (abc-) has enhanced seed dormancy and displays hypersensitivity   to exogenous ABA. In addition, higher ABA contents were detected in abc-   seeds after imbibition. These evidences suggest a negative role of   MBF1s genes in ABA-dependent inhibition of germination. The   participation of MBF1s in ethylene signal transduction pathway is also   discussed.","palabras_clave":"MBF1|ARABIDOPSIS|SEEDS|ABA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88672,"idioma_id":4,"titulo":"Synthesis and biological activity profile of novel 2-cinnamylidene-1,3-diones related to coruscanone A: promising new antileishmanial agents","resumen":"A series of 2-cinnamyliden-1,3-diones related to the natural product coruscanone A was prepared from simple commercially available precursors via Knoevenagel condensation, and evaluated for antifungal, antibacterial and antiparasitic activities. Most of the compounds tested displayed antifungal effects against opportunistic pathogen C. neoformans comparable to coruscanone A and its derivatives suggesting that the mechanism of action of this class of compounds would involve Michael addition of a nucleophilic site of the biological target on the styryl side chain instead of the previously proposed reaction at the cyclopentenedione ring. In addition, some showed good in vitro antileishmanial activity (L. donovani), one of the compounds being superior to pentamidine and comparable to amphotericin B.","palabras_clave":"LEISHMANIASIS|MALARIA|2-CINNAMYLIDENE-1,3-DIONES|CORUSCANONE A"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88673,"idioma_id":4,"titulo":"An Arsenic Fluorescent Compound as a Novel Probe to Study  Arsenic-Binding Proteins","resumen":"Arsenic-binding proteins are under continuous research. Their   identification and the elucidation of arsenic\/protein interaction   mechanisms are important because the biological effects of these   complexes may be related not only to arsenic but also to the   arsenic\/protein structure. Although many proteins bearing a CXXC motif   have been found to bind arsenic in vivo, new tools are necessary to   identify new arsenic targets and allow research on protein\/arsenic   complexes. In this work, we analyzed the performance of the fluorescent   compound APAO-FITC (synthesized from p-aminophenylarsenoxide, APAO, and   fluorescein isothiocyanate, FITC) in arsenic\/protein binding assays   using thioredoxin 1 (Trx) as an arsenic-binding protein model. The   Trx-APAO-FITC complex was studied through different spectroscopic   techniques involving UV\u2013Vis, fluorescence, atomic absorption, infrared   and circular dichroism. Our results show that APAO-FITC binds   efficiently and specifically to the Trx binding site, labeling the   protein fluorescently, without altering its structure and activity. In   summary, we were able to study a protein\/arsenic complex model, using   APAO-FITC as a labeling probe. The use of APAO-FITC in the   identification of different protein and cell targets, as well as in in   vivo biodistribution studies, conformational studies of arsenic-binding   proteins, and studies for the design of drug delivery systems for   arsenic anti-cancer therapies, is highly promising.","palabras_clave":"ARSENIC CARCINOGENESIS|CIRCULAR DICHROISM|CONFORMATIONAL STUDIES|DRUG DELIVERY SYSTEMS|THIOREDOXIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88674,"idioma_id":4,"titulo":"Survival analysis and demographic parameters of the pupal parasitoid Coptera haywardi (Hymenoptera: Diapriidae), reared on Anastrepha fraterculus (Diptera: Tephritidae)","resumen":"Coptera haywardi is an idiobiont pupal parasitoid of Tephritidae, and native to the Neotropical region. A survival analysis using a parametric survival fit approach was performed to generate survival curves and information relevant to mass rearing for augmentative biological control. Survival data for both male and female individuals were fitted to several distributions (Weibull, exponential, loglogistic, and lognormal),and the survival functions were described by means of distribution parameters selected a priori. Parasit-ism rates, adult parasitoid emergence rates, pre-oviposition and oviposition periods, sex ratio, longevity,and tandard life table parameters were also determined.  This study is an initial attempt to document the demography ofC. haywardi reared on the damaging and economically important South American fruit fly Anastrepha fraterculus.  The results of the study showed that C. haywardireached 7% of daily parasitism, with a female mean lifetime survivorship of 32.52 days and a high net reproduction rate of 17.10. The demographic parame-ters found for C. haywardiwere similar to those recorded for other fruit fly parasitoid species already used with positive results against Tephritidae in augmentative biocontrol programmes.  We conclude thatC. haywardiis potentially suitable for mass-rearing to be use in augmentative biolog-ical control programmes of A. fraterculus.","palabras_clave":"Coptera haywardi|Fruit fly parasitoids|Survival analysis|Demographic parameters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88675,"idioma_id":4,"titulo":"The socio-technical alliance. Bringing new tools to the design of policies aimed to promote social inclusion","resumen":"In this paper, we analyze the links between some cases of biodiesel production from waste cooking oil (WCO) and the passing of the Biofuels Act by the Argentinean parliament. The analysis is guided by a theoretical-methodological approach based on tools drawn from the social studies of technology field.  The employment of eatable crop in biofuel industry sparked a global debate about their drawbacks. Critics argue that it deepens the capital-intensive monoculture agricultural production, driving away small farmers and peasants from their lands.  Far from these debates, in southern Buenos Aires province, there were alternative biodiesel production experiences whose main objective was providing solutions to social and environmental problems. After the Biofuels Act was passed, the new scenario posed unprecedented challenges.  The socio-technical approach allowed operating a systemic interpretation of these processes, bringing new insights to explain the construction of sustainability ?or impracticality? of technological policies aimed to promote social inclusion.","palabras_clave":"Public policy|Social inclusion|Biofuels|Socio-technical alliances"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88676,"idioma_id":5,"titulo":"Dossier Repositorios digitales y Humanidades.  Gestión, almacenamiento y uso de los conocimientos académicos en la web: los repositorios de revistas digitales y la Historia. Nota principal","resumen":"Todos los que integramos el campo  académico conocemos la centralidad que poseen las revistas como  herramienta de actualización permanente así como también la  creciente importancia que les hemos asignado como instrumento para  calificar cuantitativa y cualitativamente la producción  científico-tecnológica de los investigadores. En uno y otro caso,  la irrupción de las nuevas tecnologías de la comunicación supuso  una reformulación de los criterios y las prácticas de la comunidad  científica a la par que obligó a sus muchas veces reticentes  miembros a una alfabetización digital acelerada que les permitiera  permanecer en los circuitos profesionales intelectuales e interactuar  con las nuevas formas de gestión de los saberes. El surgimiento y la  multiplicación de las revistas electrónicas significaron un  incremento notable de la información disponible, sobre todo a partir  de la creación de una variedad de repositorios digitales que  facilitaron la búsqueda y se volvieron espacios de consulta  indispensable. Además, tal proliferación implicó la necesidad de  introducir pautas que se adecuaran a los nuevos formatos y que  garantizaran, a la vez, la calidad, continuidad, accesibilidad y  difusión de las publicaciones sin lesionar la propiedad intelectual  de los autores. A pesar de que las sospechas iniciales en torno a las  publicaciones electrónicas fueron considerablemente mitigadas por un  proceso de normalización, no han sido aún desterradas de modo  definitivo del campo académico. No obstante ello, o mejor,  debido a ello consideramos necesario que una revista dedicada a  explorar las relaciones entre la docencia y la investigación  histórica y la web, aborde el fenómeno de los mencionados  repositorios, dando cuenta de algunas de sus características y del  material del que disponen.","palabras_clave":"REPOSITORIOS DIGITALES|REVISTAS|HUMANIDADES|PRODUCCIÓN CIENTÍFICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88677,"idioma_id":4,"titulo":"Jasmonates production by soybean roots inoculated with Bradyrhizobium japonicum","resumen":"            Little is known regarding production and function of  endogenous jasmonates (JAs) in root nodules of soybean plants inoculated with Bradyrhizobium japonicum. We  investigated (i) production of jasmonic acid (JA) and 12-oxophytodienoic acid  (OPDA) in roots of control and inoculated plants, and in isolated nodules; (ii)  correlations between JAs levels, nodule number, and plant growth during the  symbiotic process; (iii) effects of exogenous JA and OPDA on nodule cell number  and size. In roots of control plants, JA and OPDA levels reached a maximum at  day 18 after inoculation; OPDA level was 1.24 times that of JA. In roots of  inoculated plants, OPDA peaked at day 15, whereas JA level did not change  appreciably. Shoot dry matter (DM) of inoculated plants was higher than that of  control at day 21. Chlorophyll a  decreased more abruptly in control plants than in inoculated plants, whereas b decreased gradually in both cases.  Exogenous JA or OPDA changed number and size of nodule central cells and  peripheral cells. Findings from this and previous studies, suggest that  increased levels of JA and OPDA in control plants are related to senescence  induced by nutritional stress. OPDA accumulation in nodulated roots suggests  its involvement in 'autoregulation of nodulation'.","palabras_clave":"Bradyrhizobium|jasmonatos|Fijación de nitrógeno|Fitohormonas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88678,"idioma_id":4,"titulo":"Phylogeography of two hybridizing southern beeches (Nothofagus spp.) with different adaptive abilities","resumen":"In phylogenetically related plant species, hybrid-ization can influence their current genetic structure. Long-lasting hybridization may be related to persistence in sharedglacial refugia, where the differential abilities of eachspecies to survive could have provided adaptations tochanging environmental conditions. In temperate SouthAmerican forests at the Patagonia region, the pattern ofQuaternary glaciations offered several opportunities forrefuge. At mid-latitudes (42° to 44° S), particular topo-graphic characteristics determined different glaciation pat-terns, defining the existence of a transitional zone. Westudied two widespread Nothofagus species (Nothofaguspumilio, Nothofagus antarctica) characterized by contrast-ing plasticity. We screened 40 coupled populations withthree cpDNA markers and found 14 different haplotypes.Both species presented significant phylogeographic struc-ture (NST&#8805;GST, p&gt;0.001), with two geographically segre-gated lineages (north?south). A latitudinal cline in thedistribution of genetic diversity was determined, with mostvariable populations in the north (35°?41° S). Populationdiversity diminished to southern latitudes, but a particularsituation occurs between 42°S and 44°S. The transitionzone, a putative refuge area, presented unique haplotypes.The more plastic species, N. antarctica, probably persistedin more refuge areas, which could be reflected in its higherlevels of diversity. In these species, sympatric distributionexplains introgression (IG&gt;IGe), but the differential levelsof haplotype sharing between N. pumilio and N. antarcticaat population level are relevant to the understanding ofphylogeographic patterns. Hybridization may have facili-tated recruitment in the onset of postglacial colonization bymiddle to long-distance pollen dispersal. In the currentscenario of climate change, the presence of hybrids withdifferent plastic responses is of remarkable importance.","palabras_clave":"Nothofagus pumilio|N. antarctica|Patagonia|Genetic structure|Introgression|Chloroplast DNA markers|Shared refugia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88679,"idioma_id":4,"titulo":"U-Pb zircon constraints on the age of the Cretaceous Mata Amarilla Formation, Southern Patagonia, Argentina: its relationship with the evolution of the Austral Basin","resumen":"Despite the abundant fossil content of the Mata Amarilla Formation (Southern Patagonia, Santa Cruz Province, Argentina), its age has always generated a considerable number of questions and debates. The chronological data provided by invertebrates, dinosaurs, fish, turtles, plesiosaurs and fossil flora are contradictory. In this&nbsp;work, twenty U?Pb spot analyses by laser ablation were carried out on the outer parts of the zoned zircon crystals from a tuff layer of the middle section of the Mata Amarilla Formation, yielding a U?Pb concordia age of 96.23 ± 0.71 Ma, which corresponds to the middle Cenomanian. The deposition of the lower section of the Mata Amarilla Formation marks the onset of the foreland stage of the Austral Basin (also known as Magallanes Basin); this transition is characterised by the west?east shift of the depositional systems, which is consistent with the progradation of the Cretaceous fold-and-thrust belt. Thus, the onset of the foreland stage could have occurred between the upper Albian and lower Cenomanian, as the underlying Piedra Clavada Formation is lower Albian in age. On comparing the data obtained with information from the Última Esperanza Province in Chile, it can be suggested that the initiation of the closure of the Rocas Verdes Marginal Basin occurred simultaneously. ","palabras_clave":"Mata Amarilla Formation|zircons|laser ablation|Austral Basin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88680,"idioma_id":4,"titulo":"Sequence stratigraphic analysis of Cenomanian greenhouse palaeosols: A case study from southern Patagonia, Argentina","resumen":"The aim of this contribution is to analyse extrinsic (i.e., tectonics, climate and eustasy) and intrinsic (i.e., palaeotopography, palaeodrainage and relative sedimentation rates) factors that controlled palaeosol development in the Cenomanian Mata Amarilla Formation (Austral foreland basin, southwestern Patagonia, Argentina). Detailed sedimentological logs, facies analysis, pedofeatures and palaeosol horizon identification led to the definition of six pedotypes, which represent Histosols, acid sulphate Histosols, Vertisols, hydromorphic Vertisols, Inceptisols and vertic Alfisols. Small- and large-scale changes in palaeosol development were recognised throughout the units. Small-scale or high-frequency variations, identified within the middle section are represented by the lateral and vertical superimposition of Inceptisols, Vertisols and hydromorphic Vertisols. Lateral changes are interpreted as the result of intrinsic factors to the depositional systems, such as the relative position within the floodplain and the distance from the main channels, that condition the nature of parent material, the sedimentation rate and eventually the palaeotopographic position. Vertical stacking of different soil types is linked to avulsion processes and the relatively abrupt change in the distance to main channels as the system aggraded. The large-scale or low-frequency vertical variations in palaeosol type occurring in the Mata Amarilla Formation are related to long-termchanges in depositional environments. The lower and upper sections of the studied logs are characterised by Histosols and acid sulphate Histosols, and fewhydromorphic Vertisols associatedwith lowgradient coastal environments (i.e., lagoons, estuaries and distal fluvial systems). At the lower boundary of the middle section, a thick palaeosol succession composed of vertic Alfisols occurs. The rest of the middle section is characterised by Vertisols, hydromorphic Vertisols and Inceptisols occurring on distal and proximal fluvial floodplains, respectively. The palaeosol succession for the Mata Amarilla Formation can be analysed within a sequence stratigraphic scheme considering changes in depositional environments in relation to accommodation\/supply conditions. The results contrast with classical models, mainly in that the palaeosols of the Mata Amarilla Formation are relativelywell-developed throughout thewhole sequence, including transgressive periods of relatively high aggradation rate. Also, even when during regressive episodes, when a thick palaeosol succession that marks the sequence boundary is developed in the classical models, the lack of incised valleys in this succession led to the preservation of thick palaeosol successions during lowstand conditions. The vertical and lateral palaeosol distribution identified in the Mata Amarilla Formation could be eventually extrapolated to other sequences deposited during climate optimums.","palabras_clave":"Cenomanian greenhouse|Palaeosols|Sequence stratigraphic model|Allocyclic and autocyclic controls|Austral Basin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88681,"idioma_id":5,"titulo":"Evolución paleoambiental de la Formación Río Mayer, Cretácico inferior, Cuenca Austral, provincia de Santa Cruz, Argentina","resumen":"The marine deposits of the Río Mayer Formation are part of the initial filling of the Austral Basin, which is developed in the southernmost part of South America, including the south of Chile and Argentina (southwestern Patagonia, Santa Cruz and Tierra del Fuego Provinces, Figs. 1, 2). The study area is located between the San Martín and Argentino lakes in the Santa Cruz Province (Fig. 3). The Río Mayer Formation (Fig. 2) was studied in three main localities, where detailed sedimentary logging was undertaken (Figs. 4, 5), taking into account the lithology, the primary sedimentary structures, the palaeontological content, rock bodies geometry, their orientation and the hierarchy as well as the contacts with underlying and overlying units.Eighteen sedimentary facies were defined (Figs. 6, 7; Table 1), which were grouped into three facies association representing different sedimentary palaeoenvironments, like marine outer platform (AF 1), marine outer platform influenced by a deltaic system (AF 2) and prodelta (AF 3) (Fig. 8, Tables 1, 2).The facies of the outer platform palaeoenvironment corresponds to the rocks traditionally assigned to the Río Mayer Formation, according to the available bibliography, and deposited by hemipelagic and authigenic processes interrupted by episodic sedimentation. The deposits of the outer platform influenced by a deltaic system palaeoenvironment are similar to the above mentioned but presents continental fossils that indicate a deltaic source.Finally, AF 3 of a prodelta palaeoenvironment is dominated by sandy\/heterolithics levels associated with turbidity currents and hyperpycnal flows originated in a delta front. The best and most complete exposures of the unit were observed in the Río Guanaco locality, where palaeoenvironmental interpretations were performed, allowing the division of the 350 m-thick unit in three sections (Fig. 9). The lower section is composed mainly by black shales with both tabular and concretional marls levels (AF 1). Trace fossils are not recorded in this section, but ammonites, belemnites and bivalves are frequent. It has been interpreted as accumulated in a distal platform, under anoxic conditions. The middle section is characterized by bioturbated black marls and shales, with wellpreserved Zoophycos ichnofacies (Richiano et al., in press), occurring in a distal platform depositional environment. Body fossils are frequent, especially belemnites. The upper section is composed of massive black mudstones with intercalations of very fine- to fine-grained sandstones and less frequent conglomerates. In this section both debris flows and distal low-density turbidity current deposits were identified. Zoophycos ichnofacies and Ophiomorpha rudis ichnosubfacies were recognized in association with molds of petrified wood containing Teredolites isp. (Richiano et al., in press). The presence of turbulent currents and large trace fossils suggest a more oxygenated conditions.At Lago San Martín and Estancia La Vega localities the most significant characteristic is the presence of prodeltaic deposits in the transition between Río Mayer Formation and Piedra Clavada formations (Fig. 9).To sum up, after the Upper Jurassic rifting stage of the Austral Basin, the Springhill Formation represents the initial infill of the extensional structures. After that, during the Berriasian (Fig. 10a), the levels of the lower section of the Río Mayer Formation started to accumulate in the Río Guanaco area. During the Valanginian (Fig. 10b), an acceleration in the transgression generated the accumulation of the Springhill Formation in the Lago San Martín area while in the Río Guanaco region the middle section of the Río Mayer Formation developed. Between the Hauterivian and the Barremian all the study area was under distal platform conditions (Fig. 10c).A major change in the sedimentary systems of the Austral Basin during the Lower Cretaceous is the development of the deltaic Piedra Clavada Formation (Fig. 10d). This event generated two different palaeoenvironments in the Río Mayer Formation.Prodeltaic deposits are present to the north, while sediments of distal platform conditions with highly frequent sandy levels prevail southwards. Finally a new transgression indicates the beginning of the Cerro Toro and Mata Amarilla formations in the middle Albian- lower Cenomanian (Fig. 10e).Zoophycos ichnofacies (Richiano et al., in press), occurring in a distal platform depositional environment. Body fossils are frequent, especially belemnites. The upper section is composed of massive black mudstones with intercalations of very fine- to fine-grained sandstones and less frequent conglomerates. In this section both debris flows and distal low-density turbidity current deposits were identified. Zoophycos ichnofacies and Ophiomorpha rudis ichnosubfacies were recognized in association with molds of petrified wood containing Teredolites isp. (Richiano et al., in press). The presence of turbulent currents and large trace fossils suggest a more oxygenated conditions.At Lago San Martín and Estancia La Vega localities the most significant characteristic is the presence of prodeltaic deposits in the transition between Río Mayer Formation and Piedra Clavada formations (Fig. 9).To sum up, after the Upper Jurassic rifting stage of the Austral Basin, the Springhill Formation represents the initial infill of the extensional structures. After that, during the Berriasian (Fig. 10a), the levels of the lower section of the Río Mayer Formation started to accumulate in the Río Guanaco area. During the Valanginian (Fig. 10b), an acceleration in the transgression generated the accumulation of the Springhill Formation in the Lago San Martín area while in the Río Guanaco region the middle section of the Río Mayer Formation developed. Between the Hauterivian and the Barremian all the study area was under distal platform conditions (Fig. 10c).A major change in the sedimentary systems of the Austral Basin during the Lower Cretaceous is the development of the deltaic Piedra Clavada Formation (Fig. 10d). This event generated two different palaeoenvironments in the Río Mayer Formation.Prodeltaic deposits are present to the north, while sediments of distal platform conditions with highly frequent sandy levels prevail southwards. Finally a new transgression indicates the beginning of the Cerro Toro and Mata Amarilla formations in the middle Albian- lower Cenomanian (Fig. 10e).","palabras_clave":"pelitas negras|análisis de facies|plataforma externa|trazas fósiles|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88682,"idioma_id":4,"titulo":"Assessment of lettuce quality during storage at low relative humidity using Global Stability Index methodology","resumen":"During postharvest storage, lettuce is usually exposed to adverse conditions (e.g. low relative humidity) that reduce the vegetable quality. In order to evaluate its shelf life, a great number of quality indices must be analyzed requiring careful experimental design and large time consumption. In this work, the modified Global Stability Index (GSI) method was applied to estimate the quality of butter lettuce at low relative humidity during post harvest storage discriminating three lettuce zones (internal, middle and external). The results indicated that for external zone the more relevant indices were relative water content (RWC), water content (WC), ascorbic acid (AA), total mesophilic (MT), for middle zone were RWC, WC, total chlorophyll, AA and for internal RWC, bound water, WC and MT. A mathematical model between GSI and overall visual quality, within the different zones of the lettuce, was presented. Moreover, the Weibull distribution was applied to estimate maximum product storage time.","palabras_clave":"BUTTER LETTUCE|QUALITY INDICES|SHELF LIFE|MATHEMATICAL MODELLING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88683,"idioma_id":4,"titulo":"Chemical and physical properties of Aloe vera (Aloe barbadensis Miller) gel stored after high hydrostatic pressure processing","resumen":"The aim of this study was to evaluate the influence of high hydrostatic pressure (150,   28  250, 350, 450 and 550 MPa) applied for 5 minutes on antioxidant capacity, total   29  phenolic content, color, firmness, rehydration ratio and water holding capacity of aloe   30  vera gel stored for 60 days at 4 ºC. The analyzed properties of the pressurized gel   31  showed significant changes after the storage period. At 550 MPa the total phenolic   32  content showed the highest increase. Nevertheless,  a decrease in antioxidant capacity   33  was noted in all pressurized gel samples, when compared to control sample (p<0.05).   34  At pressure levels between 150 and 250 MPa change in product color was least.   35  Application of high hydrostatic pressure caused a loss in gel firmness, showing the   36  lowest value at 150 MPa (p<0.05). However, the unpressurized sample showed a higher   37  decrease in firmness, indicating a preserving effect of this property by high pressure   38  processing. Rehydration capacity studied by means of rehydration ratio and water   39  holding capacity showed evidence of modifications in the food matrix due to   40  application of high hydrostatic pressure.","palabras_clave":"CCC|CC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88684,"idioma_id":4,"titulo":"Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells","resumen":"Chemotherapeutics represent the main approach for the treatment of   leukemia. However, the occurrence of adverse side effects and the   complete lack of effectiveness in some cases make it necessary to   develop new drugs. As part of our screening program to evaluate the   potential chemotherapeutic effect of natural coumarins, we investigated   the anti-leukemic activities of a series of six prenylated coumarins   isolated from the stem bark of Toddalia asiatica (Rutaceae). Among   these, 6-(3-methyl-2-butenyl)-5,7-dimethoxycoumarin (toddaculin)   displayed the most potent cytotoxic and anti-proliferative effects in   U-937 cells. To determine whether these effects resulted from induction   of cell death or differentiation, we further evaluated the expression of   several apoptosis and maturation markers. Interestingly, while   toddaculin at 250 &#956;M was able to induce apoptosis in U-937 cells,   involving decreased phosphorylation levels of ERK and Akt, 50 &#956;M   toddaculin exerted differentiating effects, inducing both the capacity   of U-937 cells to reduce NBT and the expression of differentiation   markers CD88 and CD11b, but no change in p-Akt or p-ERK levels. Taken   together, these findings indicate that toddaculin displays a dual effect   as a cell differentiating agent and apoptosis inducer in U-937 cells,   suggesting it may serve as a pharmacological prototype for the   development of novel anti-leukemic agents.","palabras_clave":"TODDACULINA|CUMARICOS|LEUCEMIA|APOTOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88685,"idioma_id":4,"titulo":"Crevice corrosion kinetics of nickel alloys bearing chromium and molybdenum","resumen":"The crevice corrosion kinetics of alloys C-22, C-22HS and HYBRID-BC1 was   studied in several chloride solutions at 90&nbsp;°C. The crevice corrosion   resistance of the alloys increased with PREN (Pitting Resistance   Equivalent Number), which is mainly affected by the Mo content in the   alloys. The crevice corrosion kinetics of the three alloys was analyzed   at potentials slightly higher than the repassivation potential. Crevice   propagation was controlled by ohmic drop in the more dilute chloride   solutions, and by charge transfer in the more concentrated chloride   solutions. Ohmic drop was not a necessary condition for crevice   corrosion to occur.","palabras_clave":"Nickel alloys|Crevice corrosion|Repassivation|N06022"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88686,"idioma_id":4,"titulo":"The genus Guerrerostrongylus (Nematoda, Heligmonellidae) in cricetid rodents from the Atlantic Rain Forest of Misiones, Argentina: emended description of Guerrerostrongylus zetta (Travassos, 1937) and description of a new species","resumen":"Two species of Guerrerostrongylus Sutton and Durette-Desset, 1991, are reported in cricetid rodents from the Atlantic rain forest of Misiones, Argentina. Guerrerostrongylus zetta (Travassos, 1937) is redescribed on the basis of material collected from Oligoryzomys nigripes from Argentina and material loaned by CHIOC from Brazil. It is characterized by a synlophe with about 40\u201345(35\u201348) well-developed cuticular ridges, caudal bursa with long rays 6 and dorsal ray divided at mid-length, and well-sclerotized spicules with marked twisting. It was found with a prevalence of 100% in O. nigripes (14 hosts examined); however, it was not found in its type host Nectomys squamipes (4 hosts examined). Guerrerostrongylus ulysi n. sp., which is described from Sooretamys angouya, differs from the remaining species in the genus mainly by a synlophe with a strong reduction of the cuticular ridges and struts on the right side, and by a heart-shaped caudal bursa, with short rays 6 and a dorsal ray divided distally. It was found with a prevalence of 100% in 5 hosts examined.","palabras_clave":"GUERREROSTRONGYLUS ULYSI N SP|GUERREROSTRONGYLUS ZETTA|MISIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88687,"idioma_id":4,"titulo":"A NEW MOLINEID (TRICHOSTRONGYLINA) PARASITE OF DASYPUS HYBRIDUS (XENARTHRA: DASYPODIDAE) FROM ARGENTINA","resumen":"Delicata abbai n. sp. collected from the small intestine of the southern long-nosed armadillo, Dasypus hybridus, from Argentina is herein described. This new species is characterized by vulvar opening within second half of body length, female tail conical, ending bluntly with a terminal spine, complex spicules, presence of a bursal membrane supported by 2 small rays, and a synlophe with bilateral symmetry and 26 cuticular ridges. By the morphology of the caudal bursa, caudal end of female, and shape of spicules, the new species resembles Delicata cameroni Travassos, 1935 and Delicata variabilis Travassos, 1935. However, it differs from D. cameroni by having rays 5 and 6 diverging more proximally, rays 8 shorter than the dorsal ray, and spicules with a different shape.Delicata abbai n. sp. is distinguished from D. variabilis mainly by the spicules, which have a different shape and proportion of their constitutive parts. This is the first report of a species of Delicata in Argentina.","palabras_clave":"Delicata abbai n. sp.|Molineinae|Buenos Aires"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88688,"idioma_id":4,"titulo":"Hydrogen Permeation and Corrosion Fatigue Crack Growth Rates of X65 Pipeline Steel Exposed to Acid Brines Containing Thiosulfate or Hydrogen Sulfide","resumen":"Corrosion fatigue crack growth rates were obtained for X65 pipeline steel in acid brines containing thiosulfate (S2O32&#8722;) or hydrogen sulfide (H2S).   Samples were exposed for 72 h at the open-circuit potential to allow   bulk hydrogen charging. The corrosion fatigue crack growth rate   increased with partial pressure of H2S and correlated with   the steady-state flux of hydrogen permeation during corrosion in the   same solutions. The rate of hydrogen absorption increased with   increasing S2O32&#8722; concentration to a maximum at 10&#8722;3 M S2O32&#8722;, owing to a competition between increased surface concentration of H2S from S2O32&#8722; reduction and increased rate of iron sulfide film formation. Corrosion fatigue behavior in S2O32&#8722;-containing acidified brines is the same as in solutions with low partial pressures of H2S, in accordance with predictions from the hydrogen permeation results. This suggests that, for corrosion fatigue studies, S2O32&#8722; solutions are possible candidates for replacement of H2S gas, as long as the H2S   partial pressure of interest is low. Also, the expected concentration   of hydrogen inside the metal specimen at the end of the exposure period   correlates with the rate of corrosion fatigue crack growth, suggesting   that hydrogen charged during the pre-charging period controls corrosion   fatigue crack growth.","palabras_clave":"corrosion fatigue|hydrogen permeation|hydrogen sulfide|STEEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88689,"idioma_id":4,"titulo":"Corrosion Behavior of Carbon Steel in Acidified, Thiosulfate-Containing Brines","resumen":"The corrosion rate of carbon steel in acidified, thiosulfate-containing   brines increased with thiosulfate content. Thiosulfate also increased   the rate of cathodic and anodic reactions, as measured in polarization   curves obtained shortly after immersion of the electrode. Current from   iron dissolution was balanced by hydrogen evolution and reduction of   thiosulfate to produce hydrogen sulfide. Hydrogen sulfide production   represented a large fraction of the open-circuit corrosion current.   Carbon steel specimens exposed to thiosulfate-containing solutions   developed a film on their surface, composed of iron sulfide and   cementite. The film was a good conductor of electrons and   non-passivating. The rate of cathodic reactions measured for the   film-covered electrode was faster than in the absence of the film,   suggesting it is a good catalyst for reduction reactions. The ability of   acidified, thiosulfate-containing brines to simulate hydrogen sulfide   solutions was critically analyzed.","palabras_clave":"hydrogen sulfide|pipeline steel|sour corrosion|thiosulfate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88690,"idioma_id":4,"titulo":"Reaction Paths of Thiosulfate during Corrosion of Carbon Steel in Acidified Brines","resumen":"Corrosion tests with gaseous H2S require special facilities with safety features, because H2S is a toxic and flammable gas. The possibility of replacing H2S with thiosulfate (S2O32&#8722;), a non-toxic anion, for studying stress corrosion cracking of stainless and carbon steels in H2S solutions was first proposed by Tsujikawa in 1993. H2S production was detected in presence of carbon steel corroding in acidified thiosulfate-containing solutions. In this paper,                       the kinetics of H2S evolution are used to estimate the range of partial pressure of H2S that can be simulated with thiosulfate solutions. It was determined that acid brines containing 10&#8722;4 M and 10&#8722;3 M S2O32&#8722; could be used for replacing continuous bubbling of dilute H2S\/N2 mixtures in tests of degradation of carbon steels, with H2S partial pressures ranging between 0.03 and 0.56 kPa. The kinetics of H2S production were compared with the amount of sulfur in side reactions, like formation of iron sulfide films and elemental                       sulfur.","palabras_clave":"HYDROGEN SULPHIDE|SULFUR|CORROSION|HYDROGEN EMBRITTLENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88691,"idioma_id":4,"titulo":"Detection of Mycobacterium bovis-infected dairy herds using PCR in bulk tank milk samples","resumen":"Bovine tuberculosis (bTB) is a chronic and zoonotic disease due to Mycobacterium bovis. The tuberculosis eradication campaign carried out in Argentina has considerably improved the health situation of the herds. Here we evaluated a strategy to detect M. bovis-infected herds by Touch-Down IS6110 polymerase chain reaction (PCR) in bulk tank raw milk from dairy farms. We evaluated 177 samples from herds with the official tuberculosis free certificate (TFC) and 80 from herds without the certificate, non-tuberculosis-free certificate (NTFC), from 10 departments of Santa Fe province, Argentina. To avoid the effect of Taq polymerase inhibitors, a dilution of DNA template was performed. Positive PCR results were obtained in 102 (40%) of the samples, whereas negative ones were obtained in 155 (60%) of the samples. Importantly, 44% of NTFC and 38% of TFC samples were positive. All samples were subjected to culture in Löwenstein Jensen and Stonebrink media with no positive isolation. The negative predictive value (NPV) of PCR in the TFC group was 95%, while the positive predictive value (PPV) of PCR in the NTFC group was 51%. Based on these results, this work proposes a method that should be applied regularly to detect M. bovis--infected dairy herds, complementary to the official test of tuberculin, or purifed protein derivative (PPD), to control dairy herds, especially those free of tuberculosis.","palabras_clave":"TUBERCULOSIS|DIAGNOSIS|VETERINARY|MILK|PCR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88692,"idioma_id":4,"titulo":"Biodegradation of a vegetable oil based polyurethane and wood flour composites","resumen":"The biodegradation of a new tung oil based polyurethane and a derived wood flour (WF) composite was followed during 383 days of exposure to soil or vermiculite media. The hydrolytic degradation was the most important mechanism of deterioration in all cases. A shift of the glass transition towards higher temperatures was observed, which was explained as the result of the preferential attack and removal of free or dangling-pendant  chains that plasticize the original material. The contact angle of water was observed to decrease with exposure to soil and vermiculite media, denoting changes in the surface of the material that increased its polarity. Simultaneously, changes in color and fracture surfaces were also evident.","palabras_clave":"Vegetable oil|PolyurethanePolyurethane|Biodegradation| Wood flour composites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88693,"idioma_id":4,"titulo":"Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry","resumen":"The illicit addition of phosphodiesterase type-5 (PDE-5) inhibitors like sildenafil (Viagra) in product offered as herbal medicine or dietary supplement for male erectile dysfunction has concerned authorities in recent times. In this paper, we proposed a sensitive surfactant-coated Amberlite XADTM resin for sildenafil preconcentration method with spectrofluorimetric detection. Retention capacity of micelar coated XAD resin for sildenafil was studied and the obtained eluate was measured by spectrofluorometer at excitation and emission wavelengths of 350 and 430 nm, respectively. This method allowed the detection of sildenafil at 0.15 ng\/mL with linear range of 0.0003-7.0 &#956;g\/mL. The method has been successfully applied to the analysis of some local commercially available herbal medicines and urine.","palabras_clave":"sildenafil|herbal medicines|Spectrofluorimetric analysis|surfactant"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88694,"idioma_id":4,"titulo":"Boron Neutron Capture Therapy (BNCT) for liver metastasis: therapeutic efficacy in an experimental model","resumen":"Boron neutron capture therapy (BNCT) was  proposed for untreatable colorectal liver metastases. The  present study evaluates tumor control and potential radiotoxicity  of BNCT in an experimental model of liver metastasis.  BDIX rats were inoculated with syngeneic colon  cancer cells DHD\/K12\/TRb. Tumor-bearing animals were  divided into three groups: BPA\u2013BNCT, boronophenylalanine  (BPA) ? neutron irradiation; Beam only, neutron irradiation;  Sham, matched manipulation. The total absorbed  dose administered with BPA\u2013BNCT was 13 ± 3 Gy in  tumor and 9 ± 2 Gy in healthy liver. Three weeks posttreatment,  the tumor surface area post-treatment\/pre-treatment  ratio was 0.46 ± 0.20 for BPA\u2013BNCT, 2.7 ± 1.8 for  Beam only and 4.5 ± 3.1 for Sham. The pre-treatment tumor  nodule mass of 48 ± 19 mgfell significantly to 19 ± 16 mg  for BPA\u2013BNCT, but rose significantly to 140 ± 106 mg for  Beam only and to 346 ± 302 mg for Sham. For both end points, the differences between the BPA\u2013BNCT group and  each of the other groups were statistically significant  (ANOVA). No clinical, macroscopic or histological normal  liver radiotoxicity was observed. It is concluded that BPA\u2013  BNCT induced a significant remission of experimental  colorectal tumor nodules in liver with no contributory liver  toxicity.","palabras_clave":"Boron neutron capture therapy|BNCT|Liver metastasis|Experimental model|BDIX rats|DHD\/ K12\/TRb cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88695,"idioma_id":4,"titulo":"Boron Neutron Capture Therapy for oral pre-cancer: proof of  principle in an experimental animal model","resumen":"Objectives: Field cancerized tissue can give rise to second primary tumours, causing therapeutic   failure. Boron Neutron Capture Therapy (BNCT) is based on biological targeting and would serve   to treat undetectable foci of malignant transformation. The aim of this study was to optimize   BNCT for the integral treatment of oral cancer, with particular emphasis on the inhibitory effect   on tumour development originating in pre-cancerous  conditions, and radiotoxicity of different   BNCT protocols in a hamster cheek pouch oral pre-cancer model.  Materials and Methods:  Groups of cancerized hamsters were locally exposed  to single or  double (2 or 4 weeks apart)   applications of BNCT at different dose levels, mediated by the boron compounds   boronophenylalanine (BPA) or BPA and decahydrodecaborate (GB-10) administered jointly.   Cancerized, sham-irradiated hamsters served as controls. Clinical status, tumour development   from field cancerized tissue and mucositis were followed for 8 months.  Results: A  double  application (4 weeks apart) of BNCT mediated by GB-10 + BPA at a total dose of 10 Gy in two 5   Gy doses rendered the best therapeutic advantage (63% - 100% inhibition of tumour development   from field cancerized tissue), minimizing dose-limiting mucositis.  Conclusion: BNCT can be   optimized for the integral treatment of head and neck cancer, considering the implications for field   cancerized tissue.","palabras_clave":"BNCT|hamster cheek pouch oral pre-cancer model|field cancerization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88696,"idioma_id":4,"titulo":"PALAEODEMECOLOGICAL ANALYSIS OF INFAUNAL BIVALVES ?LEBENSSPUREN? FROM THE MULICHINCO FORMATION, LOWER CRETACEOUS, NEUQUÉN BASIN, ARGENTINA","resumen":"The study of palaeodemecological features requires some particular taphonomic conditions. These conditions were met in the Mulichinco Formation (Valanginian), where burrowing bivalve trace fossils are widespread and often appear in cross section on bedding surfaces. Two groups of such beds were analyzed, measuring population density, spatial distribution, size distribution and horizontal orientation of the burrows. The palaeoenvironment was established by means of a detailed sedimentological analysis, and the bivalve fauna present was checked, in order to attempt identifying their potential producers. High population densities were found for both groups, indicating favourable physical conditions and good food supply, while differences in both spatial and size distributions were noticed between them; on most surfaces there was no preferred orientation. The first group (group A) showed a uniform pattern of spatial distribution and larger traces, with a remarkable absence of small sizes. In the second group (group B), the spatial distribution pattern is indistinguishable from a random distribution (except one case in which the pattern appears to be aggregated). Group A is interpreted as a set of escape traces made by deep burrowers in response to storm deposition, while group B is considered as resting\/escape traces made by shallow burrowers in tide-dominated environments. Palaeodemecological studies of this kind are potentially useful tools for sedimentary and basin analyses.","palabras_clave":"BIVALVIA|SPATIAL DISTRIBUTION|POPULATION DENSITY|EARLY CRETACEOUS|VALANGINIAN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88697,"idioma_id":4,"titulo":"Performance of Cactoblastis cactorum (Berg) (Lepidoptera: Pyralidae) on South and North American Opuntia species occurring in Argentina.","resumen":"The cactus moth, Cactoblastis cactorum (Berg), is native to South America. Since its unintentionalarrival to the United States in 1989 and to Mexican islands in 2006, it has becomea serious threat to the diversity of both wild and cultivated species of Opuntia Mill. in NorthAmerica. The native ecological host range of C. cactorum has not been directly ascertainedand host acceptance is unclear. Taxonomic nomenclature of Opuntia spp. has been confusing,contradictory, and rapidly changing, leading to inaccurate conclusions about host plantuse by C. cactorum in its native South American range. This study was conducted to betterunderstand the biology and ecology of C. cactorum in Argentina by evaluating, underlaboratory conditions, the insects? performance (survivorship, development time, potentialfecundity) on 8 Opuntia spp. occurring in Argentina. Feeding trials were conducted on 5Opuntia spp. native to Argentina and 3 Opuntia spp. native to Mexico. Cactoblastis cactorumlarvae failed to feed on 2 native Opuntia spp., and had their greatest performanceon the North American O. ficus-indica (L). Mill. and O. robusta H. L. Wendl. ex Pfeiff., andthe South American O. arechavaletae Speg. Because the insects for the experiments wereoriginally collected on O. ficus-indica, a reciprocal cross feeding experiment with insectscollected on O. megapotamica Arechav. was also conducted to test for a potential host plantmediatedlocal adaptation effect. Some evidence for host plant adaptation was detected inpopulations collected on the South American host, O. megapotamica. Local adaptation, asdocumented here, could have consequences for the invasion process of C. cactorum in NorthAmerica.","palabras_clave":"cactus moth|prickly pear cactus|Opuntia ficus-indica|insect performance|host plants"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88698,"idioma_id":4,"titulo":"Seasonal variability of metazooplankton in coastal sub-Antarctic waters (Beagle Channel)","resumen":"The aim of this study was to analyse the variability in the species composition and abundance of the metazooplankton community in different coastal areas of the Beagle Channel (southern tip of South America) during a seasonal cycle. Sampling was conducted during November (spring) 2005, March (summer), June (autumn) and September (winter) 2006 at 12 coastal stations. Copepods were the most abundant group throughout the study, and their assemblages were composed of a mixture of species typical of the south-western Atlantic, the south-eastern Pacific and the Southern Ocean. Among them, Oithona similis, Ctenocalanus citer and Drepanopus forcipatus were the dominant species. The copepod Acartia tonsa was the only taxon that displayed a spatial pattern of abundance, showing higher densities in areas with lower salinities. The community structure showed a strong temporal pattern. The metazooplankton community in March and June was mainly composed of copepods, while in November and September the community showed a greater diversity. In these two months high densities of meroplanktonic larvae were found, in coincidence with higher chlorophyll-a concentration. This temporal pattern seems to be more dependent on primary production than on physical factors such as temperature or salinity. The absence of a clear spatial pattern may suggest that the studied area of the Beagle Channel behaves as a semi-enclosed water body. ","palabras_clave":"Zooplankton|Community structure|Beagle Channel|Sub-Antarctic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88699,"idioma_id":4,"titulo":"Biocontrol of Botrytis cinerea in table grapes by non-pathogenic indigenous Saccharomyces cerevisiae yeasts isolated from viticultural environments in Argentina","resumen":"Botrytis cinerea, the causal agent of gray mold, is an important disease of grapes. Yeasts are members of the epiphytic microbial community on surfaces of fruits and vegetables and because some yeasts inhibit fungi they are used as biocontrol agents. The major objective of the present work was to isolate yeasts from grapes, vineyard soil, and grape must and select them for their ability to prevent gray mold onset after harvest. Yeasts that were found effective against the fungus were also assayed for their possible pathogenicity in humans. Two antagonism experiments were performed to study the effect of yeasts on B. cinerea, an in vitro study with Czapeck Yeast Extract Agar and an in vivo study with grape berries at 2 &#9702;C and 25 &#9702;C; both experiments were conducted at different yeast concentrations (105, 106 and 107 cfu\/mL). Antagonists were subsequently assayed for their ability to colonize and grow in fruit wounds. The biocontrol yeasts were also examined for their possible pathogenicity in humans: phospholipase and proteolytic activity, growth at 37 &#9702;C and 42 &#9702;C, pseudohyphal formation and invasive growth. A total of 225 yeasts belonging to 41 species were isolated from must and grape berries and 65 of them, representing 15 species, exhibited in vitro inhibition of B. cinerea at 25 &#9702;C. These 65 biocontrol yeasts were subsequently assayed in vivo and 16 of them (15 Saccharomyces cerevisiae and 1 Schizosaccharomyces pombe) showed antagonistic properties against B. cinerea at 25 &#9702;C. Only one isolate (S. cerevisiae BSc68) was able to inhibit mycelial growth of B. cinerea on grape berries at both 2 &#9702;C and 25 &#9702;C. The biomass of this strain in grape wounds increased 221.5-fold at 25 &#9702;C after 3 d and 325.5-fold at 2 &#9702;C after 10 d of incubation. An increase in the concentration of certain yeasts significantly enhanced their antagonistic activity. All yeast isolates determined as biocontrol agents under in vivo conditions were isolated from fermenting musts. Twelve biocontrol agents (S. cerevisiae) revealed one or more phenotypical characteristics associated with pathogenicity in humans but none of them showed all characteristics together. The fact that there exist few reports on S. cerevisiae and none on Sch. pombe as biocontrol agents against B. cinerea makes our results even more relevant.","palabras_clave":"Botrytis cinerea |table grapes |Saccharomyces cerevisiae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88700,"idioma_id":4,"titulo":"Removal efficiency of Cr(VI) by indigneous Pichia sp. isolated from textile factory effluent","resumen":"Removal Efficiency of Cr(VI) by Indigenous Pichia sp. isolated from Textile Factory Effluent.doi: 10.1100\/2012\/708213","palabras_clave":"Pichia sp.|Removal Efficiency of Cr(VI)|Textile Factory Effluent"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88701,"idioma_id":4,"titulo":"Cr(VI) reduction by cell-free extracts of Pichia jadinii and Pichia anomala isolated from textile-dye factory effluents","resumen":"Chromium-resistant yeasts isolated from contaminated environments can be used to reduce toxic Cr(VI). This study assessed in vitro reduction of hexavalent chromium using crude chromate reductase (CChR) of Pichia jadinii M9 and Pichia anomala M10, two yeasts isolated from a textile-dye factory effluent. CChRs were characterized based on optimal temperature, pH, use of electron donors, metal ions and initial Cr(VI) concentration in the reaction mixture. Both CChRs shows an increase in Cr(VI) reductase activity with addition of NAD(P)H as electron donor and were highly inhibited by Hg2+ and Mn2+. The CChR from P. jadinii M9 showed the highest chromate reductase activity at 60ºC and pH 6.0 in the presence of Cu2+ or Na+, while P. anomala M10 CChR had the maximum activity at 50ºC and pH 7.0 in presence of Cu2+. Initial Cr(VI) concentrations of 1.3 and 1.7 mM for CChRs of P. jadinii M9 and P. anomala M10 respectively were inhibitory.","palabras_clave":"chromium (VI) reduction|Chromate reductase |yeasts"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88702,"idioma_id":4,"titulo":"In Vitro Antiviral Activity of Heterophyllaea pustulata Extracts","resumen":"The antiviral activity was tested of different polarity extracts, with differing chemical composition, obtained from aerial parts of Heterophyllaea pustulata Hook f. (Rubiaceae) against Herpes Simplex Virus Type I (HSV-I) and Saint Louis encephalitis virus (SLEV). The Vero cell line was employed as a host cell for the antiviral assessment of benzene (Ben), ethyl acetate (EtOAc) and ethanol (EtOH) extracts by means of the Neutral Red uptake assay and plaque reduction test. None of the extracts showed antiviral activity against SLEV. Only the extracts (Ben and EtOAc) with a high content of anthraquinones (AQs) inhibited HSV-I replication, exhibiting Selectivity Index (SI) values of 2.7 and 2.4, respectively. Therefore, these extracts could be good candidates as natural sources for antiviral drug development against HSV-I.","palabras_clave":"ANTIVIRAL|HETEROPHYLLAEA PUSTULATA|ANTRHAQUINONE EXTRACTS|CYTOTOXICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88703,"idioma_id":5,"titulo":"Los proyectos de desarrollo rural y forestal en contextos de pluriculturalidad. Las comunidades indígenas en la jurisdicción de la 'Corporación Interestadual Pulmarí', Provincia de Neuquén, Argentina","resumen":"El objetivo del presente artículo esanalizar los efectos de las políticas sociales y los proyectos de desarrollorural, en especial aquellos que incorporan la actividad forestal comercial, encomunidades del pueblo indígena Mapuche, en el sur de la Argentina (Prov. deNeuquén). La región analizada es sumamente particular, ya que se trata de unterritorio administrado bajo jurisdicción de la Corporación InterestadualPulmarí ente conformado por tierras de la Nación (Estado Federal) y laProvincia- donde se asientan además de las poblacionesoriginarias, productores ganaderos y concesionarios privados, configurando uncontexto de suma diversidad y a la vez conflictividad.","palabras_clave":"PROYECTOS DE DESARROLLO RURAL.|PUEBLO INDÍGENA MAPUCHE|ACTIVIDAD FORESTAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88704,"idioma_id":4,"titulo":"Cosmological constraints on non-standard inflationary quantum collapse models","resumen":"We briefly review an important shortcoming -unearthed in previous works- of the standard version of the inflationary model for the emergence of the seeds of cosmic structure. We consider here some consequences emerging from a proposal inspired on ideas of Penrose and Diosi [R. Penrose, The Emperor's New Mind. Concerning Computers, Minds and Laws of Physics (1989).][R. Penrose, in Physics meets Philosophy at the Planck Scale: Contemporary Theories in Quantum Gravity, edited by C. Callendar and N. Huggett (2001), pp. 290?+.][L. Diosi, Phys. Lett. A 120, 377 (1987).][L. Diosi, Phys.&nbsp; Rev. A 40, 1165 (1989).] about a quantum-gravity induced reduction of the wave function, which has been put forward to address the shortcomings, arguing that its effect on the inflaton field is what can lead to the emergence of the seeds of cosmic structure [A. Perez, H. Sahlmann, and D. Sudarsky, Classical Quantum Gravity 23, 2317 (2006).]. The proposal leads to a deviation of the primordial spectrum from the scale invariant Harrison-Zel'dovich one, and consequently, to a different CMB power spectrum. We perform statistical analyses to test two quantum collapse schemes with recent data from the CMB, including the 7-yr release of WMAP and the matter power spectrum measured using LRGs by the Sloan Digital Sky Survey. Results from the statistical analyses indicate that several collapse models are compatible with CMB and LRG data, and establish constraints on the free parameters of the models. The data put no restriction on the timescale for the collapse of the scalar field modes.","palabras_clave":"COLLAPSE MODELS|INFLATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88705,"idioma_id":4,"titulo":"SUSTAINABLE OPTICALLY TRANSPARENT COMPOSITES BASED ON EPOXIDIZED SOY-BEAN OIL (ESO) MATRIX AND HIGH CONTENTS OF BACTERIAL CELLULOSE (BC)","resumen":"Production of transparent composites from totally renewable resources with extraordinary potential for different applications can be made possible using cellulose. Composites of epoxidized soybean oil (ESO)\/bacterial cellulose (BC) nanofibers have been prepared with high fiber content. Due to the nano-order scale network-like structure of BC nanofibers, composite films present high transparency even at high BC content. Transparency of films has been analyzed by UV?visible spectroscopy observing that only 15% of matrix transmittance is lost in the nanocomposites. ESO\/BC composites show better mechanical properties with increasing BC content. Composites combine high stiffness and good ductility due to the incorporation of BC network structure in ESO matrix.","palabras_clave":"Nano composites|Fibres |Fibre\/matrix bond|Atomic force microscopy (AFM)|Mechanical properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88706,"idioma_id":4,"titulo":"Super-resolution Border Segmentation and Measurement in Remote Sensing Images","resumen":"Segmentation and measurement of linear characteristics in remote sensing imagery are among the first stages in several geomorphologic studies, including the length estimation of geographic features such as perimeters, coastal lines, and borders. However, unlike area measurement algorithms, widely used methods for perimeter estimation in digital images have high systematic errors. No precision improvement can be achieved with finer spatial resolution images because of the inherent geometrical inaccuracies they commit. In this work, a superresolution border segmentation and measurement algorithm is presented. The method is based on minimum distance segmentation over the initial image, followed by contour tracking using a superresolution enhancement of the marching squares algorithm. Thorough testing with synthetic and validated field images shows that this algorithm outperforms traditional border measuring methods, regardless of the image resolution or the orientation, size, and  shape of the object to be analyzed.","palabras_clave":"Segmentation |Measurement| Perimeter| Superresolution"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88707,"idioma_id":5,"titulo":"CARACTERIZACION OPTICA DE LAS LAGUNAS SAUCE GRANDE Y CHASICO (PROVINCIA DE BUENOS AIRES)","resumen":"El objetivo de este trabajo fue evaluar las características ópticas y los parámetros físico-químicos para la zonificación de las lagunas Sauce Grande y Chasicó (provincia de Buenos Aires). Se utilizó un espectroradiómetro de campo para la obtención de los espectros de reflectancia (R). Las mediciones se realizaron en febrero de 2010. Los contenidos de clorofila ?a? fueron obtenidos en laboratorio a partir de muestras de agua superficial. Se utilizó una sonda multiparamétrica para la medición de parámetros in situ mientras que la transparencia del agua fue estimada mediante un Disco Secchi. Como resultado del análisis estadístico según la respuesta espectral del agua se obtuvieron 3 sectores para cada una de las lagunas. En la laguna Chasicó, la zona 1 representó el sector centro-Sur del cuerpo de agua; la zona 2 fue coincidente con el extremo NNO de la laguna mientras que la zona 3 se vinculó con la desembocadura del arroyo Chasicó. En el caso de la laguna Sauce Grande, las subzonas representaron: el sector NNE de la laguna (zona 1); E y SE de la laguna (zona 2) y la desembocadura del río Sauce Grande (zona 3). La máxima profundidad hallada en la laguna Chasicó fue de 9 m mientras que en Sauce Grande fue de 1,50 m. Como consecuencia, los valores de R hallados en esta última fueron superiores al 8 % y para la laguna Chasicó fueron inferiores al 6 %. Si bien ambos son cuerpos de agua someros, el efecto que ejerce el fondo sobre la R en aguas poco profundas fue mayormente evidenciado en la laguna Sauce Grande","palabras_clave":"zonas ópticas, |clorofila a,| turbidez,| lagos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88708,"idioma_id":4,"titulo":"Preliminary analysis of waves in the coastal zone of Monte Hermoso and Pehu&eacute;n Co, Argentina","resumen":"Coastal geomorphology is significantly influenced by waves because they are a major agent in removing and transporting sediments. Furthermore, any kind of human coastal activity is influenced by waves. Consequently, it is essential to know about the wave distribution of the coastal areas. The aim of this study was to analyze the waves at Monte Hermoso and Pehun Co coastal zone, Buenos Aires, Argentina. The study was based on data obtained from an oceanographic tower located on the coast of the study area, between April 2007 and July 2009, analyzed annually and seasonally. The major occurrence and frequency of the significant wave heights (Hs) and the period of significant waves (Ts) were studied. The main percentages of Hs occurred between 0.25 and 1.5 m and were related to Ts between 0 and 16 seconds. The highest Hs rates were observed in spring, whereas the lowest ones in winter. Theoretical distribution probabilities were applied and the Weibull distribution was the most appropriate fit for the data, presenting a shape parameter of 0.82 and a scale parameter of 1.73. Joint probability analysis of Hs and Ts showed that summer and spring have similar patterns with larger probabilities of locally generated waves, whereas, contrary to what it is normally expected, winter has the larger percentage of swells because of the large number of calm-wind days. Finally, the Ursell number and the flux intensity parameter were obtained to demonstrate that the waves have been able to transport the typical sediments at the tower site toward the sea. © 2012 Coastal Education & Research Foundation.","palabras_clave":"Wave distribution|incidence wave analysis|Weibull, lognormal|wave joint probability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88709,"idioma_id":4,"titulo":"Phytoplankton and physicochemical analysis on the water system of the temperate estuary in South America: Bahía Blanca Estuary, Argentina","resumen":"Under the contemporary scenario of global climate change and increasing coastal eutrophication,baseline studies of phytoplankton diversity and distribution in relation to habitat conditions constitute thefirst approach to evaluate potential shifts at the base of the food webs. Here we present data of phytoplanktonspecies composition and environmental variables in winter 2006 in a temperate estuary in South America,Argentina. The results showed that the Bahía Blanca Estuary is markedly turbid (particulate suspended matterup to 60 mg L-1) with high nutrient concentrations. Apparently, besides high light attenuation coefficients (kup to 2.7 m-1), the combination of a shallow (~7 m depth) and well mix water column in the innermost zone ofthe estuary allows light penetration (mean light intensity in the mixed zone Im 57.8 &#956;Em-2s-1 and euphotic zoneto mixed zone ratio Zeu:Zm over 0.2), intensive nutrient regeneration and eventually phytoplankton massivegrowth (up to 1.8 x 106 cells L-1). Moreover, the relatively low residence time and the low river runoff seem topromote the accumulation of nutrients and phytoplankton biomass in the head of the estuary. Anthropogenicactivities and autochthonous production are responsible of high particulate organic matter loads (8.3 ± 1.5 mgL-1). Diatoms appeared as the dominant group in winter with the emergence of Cyclotella aff. choctawatcheena(5-15 &#956;m) as the dominant species (up to 82 % of the total phytoplankton abundance). The distribution andhabitat preferences of this diatom are briefly discussed in relation to the pelagic environment in the BahíaBlanca Estuary.","palabras_clave":"Phytoplankton diversity|Diatoms|Bahia Blanca estuary|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88710,"idioma_id":4,"titulo":"Control of lemon green mold by a sequential oxidative treatment and sodium bicarbonate","resumen":"A sequential oxidative treatment (SOT), using sodium hypochlorite (NaClO) and hydrogen peroxide (H2O2) in the presence of a cupric salt inhibited in vitro growth and germination of Penicillium digitatum conidia, causal agent of citrus green mold. Here, modifications of this SOT were evaluated in vivo to control this disease in inoculated lemons. The treatment that consisted of two sequential 2-min baths: one with 200 mg L&#8722;1 NaClO followed by a second with 600 mmol L&#8722;1 H2O2 in the presence of 6 mmol L&#8722;1 CuSO4, resulted in 50% of disease control. When this treatment was combined with a third 2-min bath containing 30 g L&#8722;1 NaHCO3 at 37 ¡ÆC (SOT-NaHCO3) and applied at 24 h post-inoculation, green mold incidence was reduced to ¡­5%. In non-inoculated lemons stored at 5 ¡ÆC for 45 d, this treatment did not modify the appearance or weight compared to untreated lemons. Furthermore, phenolic content and the oxygen consumption rate in flavedo and albedo tissues were not affected by the SOT-NaHCO3. The malondialdehyde content in flavedo tissues increased immediately after treatment, but decreased to levels similar to control fruit 2 d later. The SOT-NaHCO3 combines compounds that are safe to the environment and human health, thus it represent a potential alternative to synthetic fungicides for the integrated control of postharvest diseases.","palabras_clave":"BICARBONATO DE SODIO|HIPOCLORITO DE SODIO|LIMON|MOHO VERDE|PEROXIDO DE HIDROGENO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88711,"idioma_id":4,"titulo":"Cadmium accumulation and strategies to avoid its toxicity in roots of the citrus rootstock Citrumelo","resumen":"In order to assess implications of Cd-induced oxidative stress in roots of the citrus rootstock Citrumelo, seedlings were hydroponically exposed to two relatively realistic Cd concentrations during 7 days. Our results showed that increasing Cd concentrations in external solution were associated with higher Cd accumulations in roots. At 5 µM Cd the accumulation of Cd in roots was over 70-f higher than in aerial part (stem + leaves). Malondialdehyde (MDA), superoxide radical (O2\u2022&#8722;), hydrogen peroxide (H2O2) and lipoxygenase activity (LOX) increased in Cd-exposed roots, suggesting a metal-induced oxidative stress. The Cd treatment enhanced the activity of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and guaiacol-type peroxidase (G-POD), as well as the content of secondary metabolites i.e. soluble phenolics (SPs) and lignin. Histochemical analyses of roots showed that Cd, H2O2, (O2\u2022&#8722;), lignin and G-POD displayed a similar location pattern. Almost all analyzed parameters showed a similar dynamic tendency with increases under 5 µM Cd followed by decreases under 10 µM Cd, suggesting that a complex coordinated Cd-defensive mechanism is operating in Citrumelo roots exposed to environmental realistic Cd concentrations.","palabras_clave":"CADMIO|ESTRESOXIDATIVO|LOCALIZACION HISTOQUIMICA|PIE DE INJERTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88712,"idioma_id":5,"titulo":"Teoría Federal, organización institucional e intelectuales en la Argentina del siglo XIX","resumen":"El artículo analiza los enunciados del federalismo en Argentina, en su propuesta teórica y el sistema de organización política que establece. Se argumenta que el sistema de organización federal Argentino del siglo XIX es una propuesta genuina y no una réplica de otros sistemas. Se concluye que el federalismo de este país se enmarca en un contexto económico, político, social y cultural particular, que influye sobre los autores, condicionando sus planteos y enmarcando a las teorías en los escenarios concretos.","palabras_clave":"federalismo|constitución|Echeverría|Alberdi"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88713,"idioma_id":4,"titulo":"Rodent seed predation on tree invader species in grassland habitats of the inland Pampa","resumen":"Abstract Woody plant invasion in grassland ecosystemsis a worldwide phenomenon, and biotic interactions ascompetition and predation have been invoked as apossible barrier to woody encroachment in many ecosystems.We evaluated the role of rodents as seed predatorsin Pampean grasslands, and we assessed thedifferences in removal by rodents between one nativespecies, Prosopis caldenia (Calde´n) and one exotic species,Gleditisia triacanthos (Honey locust). The experimentwas conducted at different phases of the rodentpopulation cycle in two grassland communities, a remnantof a native grassland and a post agriculture grassland(old field). The amount of seed loss caused bypredation was estimated by a bait-removal experiment inforaging stations. We estimated the frequency of foragingstations with consumption, the overall amount ofseed predation and the individual rate of seed predation.The total amount of seed removal and the individualrate of seed removal were higher for P. caldenia than forG. triacanthos, in the native grassland than in the oldfield, and in autumn when rodent density was maximum.Overall, the role of rodents on woody seed removalvaried according to the plant species and depending onthe local conditions that vary through time and space.Keywords Grassland Æ Rodents Æ Seed predators ÆWoody invaders","palabras_clave":"Akodon azarae|seed prestaion| biotic resistance,|woody invasion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88714,"idioma_id":4,"titulo":"Seasonal pattern of herbivory, leaf traits, and productivity consumption in dry and wet Patagonian forests","resumen":"1. Endemic herbivory can influence forest ecosystem function, but howannual productivity consumption relates to seasonal resource utilisation by folivoreguilds remains poorly understood.2. Monthly changes in leaf damage and foliage traits were monitored in \u2018dry\u2019 and\u2018wet\u2019 Nothofagus pumilio (Fagales: Nothofagaceae) deciduous forests in northernPatagonia, Argentina. Herbivore-induced leaf abscission was assessed and foliarproductivity consumption was measured in the canopy and in litterfall harvests.3. Seasonal damage ranged from 8% to 32% in dry forest, but remained below 5%in wet forest although foliar quality was higher in the latter. In dry forest, dominantguilds were temporally separated; leaf miners consumed younger foliage in spring toearly summer, whereas leaf tiers prevailed in late summer to autumn. In wet forest,damage created by external chewers was concentrated in early summer.4. Insect damage induced premature leaf abscission, especially in dry forest.Although foliar production in wet forest doubled that in dry forest, the percentageof productivity lost to folivores was higher in dry (14\u201320%) than in wet(1.2\u20131.8%) forest.5. The overall greater impact of herbivory in dry forest canopies countered theexpectation that consumption would increase with plant productivity and nutritionalquality. Lower temperatures and a shorter growing season are likely to constrain","palabras_clave":"foliar productivity|Feeding guilds|leaf abscission|Nothofagus pumilio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88715,"idioma_id":10,"titulo":"Aislamiento, identificación y daños asociados al Síndrome de la Muerte Súbita en el cultivo de soja en Argentina","resumen":"Los objetivos de este trabajo fueron aislar e identificar los agentes causales del síndrome de la muerte súbita (SMS) en muestrasprovenientes de diferentes localidades de Argentina, y cuantificar la incidencia de la enfermedad y los daños causados a campo en elrendimiento. Se analizaron 215 raíces provenientes de plantas con síntoma foliares típicos de SMS para el aislamiento e identificación delos agentes causales. Para realizar las pruebas de patogenicidad se efectuaron dos bioensayos en invernáculo. Los daños fueron estimadosen un ensayo a campo situado en Pergamino a través de la cuantificación del rendimiento de muestras apareadas. El 36% (78 raíces) de lasraíces presentó signos de Fusarium, compatibles con los causantes de SMS. Los estudios morfológicos realizados permitieron identificar35 aislamientos como F. tucumaniae y 18, como F. virguliforme. Otros ocho aislamientos no pudieron identificarse. Todos los aislamientosinoculados reprodujeron los síntomas foliares típicos de SMS. Se observaron diferencias entre el peso de mil granos de plantas sanas y deplantas enfermas y entre el rendimiento potencial y el real (p<0,05). Los daños promedio fueron de 1514 kg\/ha (rango 192-3770 kg\/ha).Los resultados obtenidos corroboraron la distribución y predominio de F. tucumaniae y F. viguliforme en el área estudiada y su potencialdestructivo.","palabras_clave":"GLYCINE MAX| FUSARIUM TUCUMANIAE |FUSARIUM VIRGULIFORME| SDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88716,"idioma_id":5,"titulo":"Experiencias artístico-educativas para los obreros durante el primer peronismo","resumen":"Durante el primer peronismo (1946-1955) se diseñó una política cultural como parte de la planificación estatal que tenía en algunos casos a los obreros como receptores o productores exclusivos de la misma. Esta política cultural contenía una serie de experiencias, prácticas y formaciones artísticas donde se recurría frecuentemente a disciplinas como la música, la literatura y el teatro. Todas estas prácticas se caracterizaron por generar formas asociativas a la vez que establecer nuevos hábitos educativos y recreativos entre los trabajadores.  En la planificación cultural del primer peronismo la educación, el esparcimiento y la capacitación conformaban sus núcleos centrales, complementando el objetivo de la inserción social. No solamente se le otorgaba al obrero el derecho a la recreación, al ocio y al consumo cultural, sino también a la capacitación. Nuestro propósito es analizar la particularidad y funcionalidad de estas prácticas y formaciones, el rol de los agentes intervinientes, y las creencias, conductas e imaginarios presentes en la conformación de una identidad obrera en el marco del primer peronismo.","palabras_clave":"ARTE|OBREROS|PERONISMO|CULTURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88717,"idioma_id":4,"titulo":"First Report of Ascochyta rabiei Causing Ascochyta Blight of Chickpea in Argentina","resumen":"A severe blight of garbanzo (Cicer arietinum L.) plants was observed in May 1994 on experimental lines growing at the University of California, Westside Field Station in Fresno County. Thirty percent of the 1.5-acre field was severely infected after a period of cool and rainy weather. Symptoms included tan to brown lesions on leaves, stems, and pods and signs were brown to black pycnidia immersed in host tissue and arranged in concentric rings within the lesions. Conidia were straight, hyaline, and usually nonseptate. Based on the morphological characteristics of the fungus from infected plants and pure culture, it was identified as Ascochyta spp. To complete Koch\u2019s postulates, a monosporic fungal culture was grown on potato-dextrose agar. In two separate experiments, 15-day-old garbanzo plants were sprayed with a suspension of conidia (2 ? 104 conidia per milliliter) from the monosporic culture and covered with plastic bags for 5 days. Noninoculated plants served as controls. Lesions similar to those observed on the freld-infected plants developed on stems, petioles, and leaves 12 days after inoculation. Control plants were symptomless. The fungus was reisolated from diseased tissue and was morphologically identical to the original monosporic isolate and, thus, was identified as A. rabiei (Pass.) Labrousse. This seedborne pathogen represents a potential threat to the 15,000 acres of garbanzo grown in California. Ascochyta blight of garbanzo was first reported in the Western Hemisphere in Canada in 1974, and later in the United States in Washington in 1983 and Idaho in 1985 (1,2). This is the first report of A. rabiei infecting garbanzos in California.","palabras_clave":"GARBANZO|ASCOCHYTA BLIGHT|CICER ARIETINUM|ASCOCHYTA RABIEI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88718,"idioma_id":4,"titulo":"First Report of Races 11 and 12 of Cercospora sojina, the Causal Agent of Soybean Frogeye Leaf Spot, in Argentina","resumen":"During the growing seasons of 2008 to 2009 and 2009 to 2010, severe outbreaks of soybean (Glycine max (L.) Merr.) frogeye leaf spot, a disease caused by Cercospora sojina Hara, occurred in several areas in Argentina (1). Two surveys were conducted in soybean fields, one in 2008 that included the provinces of Buenos Aires, Córdoba, and Santa Fe, and another that was performed in 2009 in the same provinces plus three others: Entre Ríos, Santiago del Estero, and Tucumán. In both surveys, plants presented circular lesions with reddish brown-to-gray spots and bordered by typical, narrow, reddish purple margins (3). To promote sporulation and to enable identification of the causal agent, leaves of diseased plants were collected and placed in a moist chamber for 24 h with a 12-h light cycle at 25°C. Conidia were plated on potato dextrose agar medium amended with streptomycin and were incubated at 25°C and 12 h of fluorescent light. Isolated cultures sporulated in 10 days and, on the basis of their morphology, were identified as C. sojina. A total of 147 isolates were deposited at the Culture Collection of CEREMIC (Centro de Referencia de Micología). They produced one- to nine-septate hyaline, elongate to fusiform conidia that measured 54.9 ± 16.2 × 5.7 ± 1.0 &#956;m. Six isolates of C. sojina, each representing a province, were inoculated on a set of 12 differential soybean cultivars: Lee, Davis, Hood, Richland, Lincoln, Kent, Tracy, S 100, Palmetto, Peking, CNS, and Blackhawk (2). Fifteen plants of each differential were sprayed at V3 growth stage with a suspension of 6 × 104 conidia\/ml. The test was conducted twice in a complete randomized design with three replicates. Control plants were sprayed with sterile distilled water. After inoculation, plants were placed in a greenhouse bench humidity chamber at 26 to 28°C for 72 h. Disease was rated 14 days after inoculation; plants with numerous lesions were considered susceptible and each of the 15 plants was given a score of 1. Plants with small or no lesions were classified as resistant and given a score of 0. Control plants remained healthy. The pathogen was reisolated from symptomatic plants and morphological characteristics were consistent with C. sojina. Based on the response of the differentials to each isolate and on the race designations, the isolates from Buenos Aires, Córdoba, Santa Fe, and Tucumán belong to race 11, while those from Santiago del Estero and Entre Ríos province to race 12. The finding of these two races threatening soybean cultivars in Argentina may be indicative of additional races. Thus, the incorporation of multiple resistance genes may reduce the impact of the disease on soybean. To our knowledge, this is the first report of the identification of races of C. sojina in Argentina.","palabras_clave":"SOYBEAN |FROGEYE LEAF SPOT|CERCOSPORA SOJINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88719,"idioma_id":5,"titulo":"La rabia o tizón del garbanzo en Argentina: una enfermedad destructiva","resumen":"La rabia o tizón del garbanzo en Argentina: una enfermedad destructiva.","palabras_clave":"GARBANZO|SEMILLA|SANIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88720,"idioma_id":4,"titulo":".- EphA3 Expressed in the Chicken Tectum Stimulates Nasal Retinal Ganglion Cell Axon Growth and Is Required for Retinotectal Topographic Map Formation.","resumen":"            &amp;amp;amp;lt;!--   \/* Style Definitions *\/   p.MsoNormal, li.MsoNormal, div.MsoNormal  \t{mso-style-parent:'';  \tmargin:0cm;  \tmargin-bottom:.0001pt;  \tmso-pagination:widow-orphan;  \tfont-size:12.0pt;  \tfont-family:'Times New Roman';  \tmso-fareast-font-family:'Times New Roman';}  @page Section1  \t{size:612.0pt 792.0pt;  \tmargin:70.85pt 3.0cm 70.85pt 3.0cm;  \tmso-header-margin:36.0pt;  \tmso-footer-margin:36.0pt;  \tmso-paper-source:0;}  div.Section1  \t{page:Section1;}  --&amp;amp;amp;gt;        Background:Retinotopic projection onto the tectum\/colliculus constitutes the most studiedmodel of topographic mapping and Eph receptors and their ligands, the ephrins,are the best characterized molecular system involved in this process.Ephrin-As, expressed in an increasing rostro-caudal gradient in thetectum\/colliculus, repel temporal retinal ganglion cell (RGC) axons from thecaudal tectum and inhibit their branching posterior to their termination zones.However, there are conflicting data regarding the nature of the second forcethat guides nasal axons to invade and branch only in the caudaltectum\/colliculus. The predominant model postulates that this second force isproduced by a decreasing rostro-caudal gradient of EphA7 which repels nasaloptic fibers and prevents their branching in the rostral tectum\/colliculus.However, as optic fibers invade the tectum\/colliculus growing throughout thisgradient, this model cannot explain how the axons grow throughout thisrepellent molecule. Methodology\/principal findings: By using chicken retinalcultures we showed that EphA3 ectodomain stimulates nasal RGC axon growth in aconcentration dependent way. Moreover, we showed that nasal axons choosegrowing on EphA3-expressing cells and that EphA3 diminishes the density of interstitialfilopodia in nasal RGC axons. Accordingly, in vivo EphA3 ectodomainmisexpression directs nasal optic fibers toward the caudal tectum preventingtheir branching in the rostral tectum. Conclusions: We demonstrated in vitroand in vivo that EphA3 ectodomain (which is expressed in a decreasingrostro-caudal gradient in the tectum) is necessary for topographic mapping bystimulating the nasal axon growth toward the caudal tectum and inhibiting theirbranching in the rostral tectum. Furthermore, the ability of EphA3 ofstimulating axon growth allows understanding how optic fibers invade the tectumgrowing throughout this molecular gradient. Therefore, opposing tectalgradients of repellent ephrin-As and of axon growth stimulating EphA3complement each other to map optic fibers along the rostro-caudal tectal axis.","palabras_clave":"TOPOGRAPHIC MAP FORMATION|EPH-EPHRIN SYSTEM|AXON GUIDANCE|AXON GROWTH|RETINOTECTAL SYSTEM|CENTRAL NERVOUS SYSTEM DEVELOPMENT|VISUAL SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88721,"idioma_id":5,"titulo":"Sonic hedgehog (Shh)\/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum","resumen":"BackgroundSonic hedgehog (Shh)\/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh\/Gli signaling pathway activation on the proliferation dynamics and\/or the spatial organization of the NEc proliferation activity during early stages of the developing chick optic tectum (OT). In ovo pharmacological gain and loss of hedgehog function approaches were complemented with in vivo electroporation experiments in order to create ectopic sources of either Shh or Gli activator (GliA) proteins in the OT. NEc proliferating activity was analyzed at ED 4\/4.5 by recording the spatial co-ordinates of the entire population of mitotic NEc (mNEc) located along OT dorsal-ventral sections. Several space signals (numerical sequences) were derived from the mNEc spatial co-ordinate records and analyzed by different standardized non-linear methods of signal analysis.ResultsIn ovo pharmacologic treatment with cyclopamine resulted in dramatic failure in the OT expansion while the agonist purmorphamine produced the opposite result, a huge expansion of the OT vesicle. Besides, GliA and Shh misexpressions interfere with the formation of the intertectal fissure located along the dorsal midline. This morphogenetic alteration is accompanied by an increase in the mNEc density. There is a gradient in the response of NEcs to Shh and GliA: the increase in mNEc density is maximal near the dorsal regions and decrease towards the OT-tegmental boundary. Biomathematical analyses of the signals derived from the mNEc records show that both Shh and GliA electroporations change the proliferation dynamics and the spatial organization of the mNEc as revealed by the changes in the scaling index estimated by these methods.ConclusionsThe present results show that the Shh\/Gli signaling pathway plays a critical role in the OT expansion and modelling. This effect is probably mediated by a differential mitogenic effect that increases the NEc proliferation and modulates the spatial organization of the NEc proliferation activity.","palabras_clave":"SHH\/GLI PATHWAY|NEUROEPITHELIAL CELL PROLIFERATION|OPTIC TECTUM|NON-LINEAR SIGNAL ANALYSES|IN OVO CYCLOPAMINE TREATMENT|PURMORPHAMINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88723,"idioma_id":4,"titulo":"Alumina supported Fenton-like systems for the catalytic wet peroxide oxidation of phenol solutions","resumen":"Fe2O3\/Al2O3 catalysts (2% Fe) were prepared and characterized by XRD, BET, Raman, and SEM-EDAX. The systems were tested for the catalytic oxidation of phenol solutions (5000 ppm) with H2O2. The effects of reaction temperature,catalyst loading, phenol initial concentration, and H2O2:phenol molar ratio were evaluated. The relatively low oxidant consumption rates favored increased mineralization levels at substoichiometric H2O2 initial concentrations. The stability of the catalytic system was improved by means of a thermal treatment at 900°C, which did not seriously affect the overall reaction performance.","palabras_clave":"Fe2O3\/Al2O3|CWPO|phenol|H2O2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88724,"idioma_id":4,"titulo":"Efficient catalytic wet peroxide oxidation of phenol at moderate temperature using a high-load supported copper catalyst","resumen":"The use of hydrogen peroxide as the oxidizing agent in the presence of acatalyst (CatalyticWetPeroxideOxidation, CWPO) has emerged as a clean and effective alternative among other catalyticoxidation processes. The objective of this study is to evaluate the CWPO of phenol solutions using ahigh-load CuO\/Al2O3catalyst, which allows maintaining ahigh activity and efficiency compared to homogeneous copper, also overcoming secondary effluent contamination.The catalyticoxidation of aqueous phenol solutions using H2O2 as oxidizing agent and a home-made CuO\/Al2O3catalyst was studied in a batchwise slurry reactor. The applied H2O2:phenol molar ratio was only nearly 30% higher than the stoichiometric ratio. Experiments were performed at temperatures between 303 and 343 K using different catalyst loads. Phenol disappearance and TOC reduction were monitored throughout the reaction time.Both phenol and TOC conversions were larger as temperature and catalyst load increased, following the higher hydrogen peroxide decomposition rates achieved. At the highestcatalystload and temperature, complete phenol conversion and ca. 80% TOC removal was achieved. Catalyst performance in terms of phenol and TOC disappearance was maintained after 12 h of usage. Although there is evidence of some copper leaching from the catalyst, the homogeneous contribution to the overall activity is marginal.","palabras_clave":"CWPO|PHENOL OXIDATION|CuO\/Al2O3|HYDROGEN PEROXIDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88725,"idioma_id":4,"titulo":"Association Mapping in Sunflower for Sclerotinia Head Rot Resistance","resumen":"BackgroundSclerotinia Head Rot (SHR) is one of the most damaging diseases of sunflower in Europe, Argentina, and USA, causing average yield reductions of 10 to 20&#8201;%, but leading to total production loss under favorable environmental conditions for the pathogen. Association Mapping (AM) is a promising choice for Quantitative Trait Locus (QTL) mapping, as it detects relationships between phenotypic variation and gene polymorphisms in existing germplasm without development of mapping populations. This article reports the identification of QTL for resistance to SHR based on candidate gene AM. ResultsA collection of 94 sunflower inbred lines were tested for SHR under field conditions using assisted inoculation with the fungal pathogen Sclerotinia sclerotiorum. Given that no biological mechanisms or biochemical pathways have been clearly identified for SHR, 43 candidate genes were selected based on previous transcript profiling studies in sunflower and Brassica napus infected with S. sclerotiorum. Associations among SHR incidence and haplotype polymorphisms in 16 candidate genes were tested using Mixed Linear Models (MLM) that account for population structure and kinship relationships. This approach allowed detection of a significant association between the candidate gene HaRIC_B and SHR incidence (P&#8201;&lt;&#8201;0.01), accounting for a SHR incidence reduction of about 20&#8201;%. ConclusionsThese results suggest that AM will be useful in dissecting other complex traits in sunflower, thus providing a valuable tool to assist in crop breeding","palabras_clave":"Sunflower|Association Mapping|Sclerotinia sclerotiorum|SNPs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88726,"idioma_id":4,"titulo":"Analysis of genetic variability by ISSR markers in Calibrachoa caesia","resumen":"Background: Calibrachoa Cerv. (ex La Llave &amp; Lexarza) is a genus of the Solanaceae family (La Llave and Lexarza, 1825). This genus has a high ornamental and economic value due to its intrinsic variability and multiplicity of flower colours. In Argentina there are eight native species, and one of them is Calibrachoa caesia. The genetic diversity among 35 accessions of C. caesia, from five departments in the province of Misiones, was analyzed using ISSR markers. Results: Thirteen ISSR primers yielded a reproducible banding pattern, with 701 amplified loci and 98% of polymorphism. The ISSR primers 5\u2019CT, 5\u2019CA, 5\u2019GA, 5\u2019GACA, 3\u2019CAC, 3\u2019TG and 3\u2019TC generated 100% polymorphic patterns. The Rp values ranged from 23.20 to 10.29 for 5\u2019GACA and 3\u2019AG primers, respectively, while the averagevalues for MI and PIC were 0.367 and 0.231, respectively. The more informative primers were 5\u2019GACA and 5\u2019GA, and the less informative was 3\u2019AC. Simple matching coefficient of similarity varied from 0.8875 to 0.6659, indicating high levels of genetic similarity among the genotypes studied. The UPGMA cluster analysis indicated three distinct clusters; one comprised genotypes of the five departments, while the second included individuals from Guaraní and Oberá regions and the third cluster included the San Pedro individuals. The overall grouping pattern is in agreement with principal coordinate analysis (PCoA). Conclusions: The Bayesian cluster analysis revealed structuring of the C. caesia population and two clusters were identified, which correspond to UPGMA major clades. The AMOVA test for all populations showed highest genetic variation within populations (90%), meanwhile the Fst coefficient was 0.098, indicating a medium differentiation between populations. These results showed a great intrapopulation genetic diversity but no significant difference was detected among populations. In this work the use of thirteen ISSR markers, allowed the characterization of every individual examined. Therefore, the possibility of using molecular data for varietal identification is a promising tool for application in future breeding programs in the genus Calibrachoa.","palabras_clave":"ANCHORED MICROSATELLITES|MOLECULAR MARKERS|ORNAMENTAL PLANTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88727,"idioma_id":4,"titulo":"Optic tectum morphogenesis: A step-by-step model based on the temporal-spatial organization of the cell proliferation. Significance of deterministic and stochastic components subsumed in the spatial organization","resumen":"  Background: Cell proliferation plays an important morphogenetic role. This work analyzes the temporal-spatial organization of cell proliferation as an attempt to understand its contribution to the chick optic tectum (OT) morphogenesis. Results:A morphogenetic model based on space-dependent differences in cell proliferation is presented. Step1: a medial Zone of High Mitotic Density (mZHMD) appears at the caudal zone. Step2: the mZHMD expands cephalically forming the dorsal curvature and then duplicates into two bilateral ZHMDs (bZHMD). Step3: the bZHMDs move toward the central region of each hemitectum. Step4: the planar expansion of both bZHMD and a relative decrement in the dorsal midline growth produces a dorsal medial groove separating the tectal hemispheres. Step5: a relative caudal displacement of the bZHMDs produces the OT caudal curvature.Numerical sequences derived from records of mitotic cells spatial co-ordinates, analyzed as stochastic point processes, show that they correspond to 1\/f(â) processes. The spatial organization subsumes deterministic and stochastic components. Conclusions:The deterministic component describes the presence of a long-range influence that installs an asymmetric distribution of cell proliferation. i.e, an asymmetrically located ZHMD that print space-dependent differences onto the tectal corticogenesis. The stochastic component reveals short-range anti-correlations reflecting spatial clusterization and synchronization between neighboring cells.Este trabajo fue seleccionado por la Editorial como Highlight resaltando la importancia y la originalidad de nuestra tarea de investigación de intentar unir la biología experimental con la teórica, ha sido calificado como pionera 'demostrando la potencia de la modelación biomatemática para revelar nuevas ideas acerca de los mecanismos de desarrollo'Kiefer, J. C. (2012), Highlights in DD. Dev. Dyn., 241: n\/a. doi:10.1002\/dvdy.23820 ?Highlights? calls attention to exciting advances in developmental biologythat have recently been reported in Developmental Dynamics. Development is abroad field encompassing many important areas. To reflect this fact, thesection spotlights significant discoveries that occur across the entirespectrum of developmental events and problems: from new experimentalapproaches, to novel interpretations of results, to noteworthy findingsutilizing different developmental organisms.&nbsp;El Highlight puedeser encontrado en:http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.23820\/fullhttp:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dvdy.23820\/pdf","palabras_clave":"DEVELOPING CNS|MITOTIC CELL ORGANIZATION|NONLINEAR ANALYSES|MORPHOGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88728,"idioma_id":4,"titulo":"Fine-tuning the fruit-tracking hypothesis: spatiotemporal links between fruit availability and fruit consumption by birds in Andean mountain forests","resumen":"1. The fruit-tracking hypothesis predicts spatiotemporal links between changes in the abundance of fruit-eating birds and the abundance of their fleshy-fruit resources.  2. While the spatial scale of plant?frugivore interactions has been explored to understand mismatches between observed and expected fruit?frugivore patterns, methodological issues such as the consequences of measuring fruit and frugivore abundance rather than fruit availability and fruit consumption have not been evaluated.  3. Here, we explored whether predicted fruit?frugivore spatiotemporal links can be captured with higher accuracy by proximate measurements of interaction strength. We used a 6-ha grided plot in an Andean subtropical forest to study the link between (i) fruit and fruit-eating bird abundances; (ii) fruit availability and frequency of fruit consumption; and (iii) covariation between frugivore abundance and frequency of frugivory. We evaluated these links for the entire frugivore assemblage and for the four most important species using data gathered bimonthly along a 2-year period.  4. Fleshy-fruit availability and abundance varied sharply temporally and were patchily distributed in mosaics that differed in fruit quantity. Fruit availability and abundance also varied along spatial gradients extended over the whole study plot. We found a strong response of the entire frugivorous bird assemblage to fruit availability over time, and a weakly significant relationship over space at the local scale. The main frugivore species widely differed in their responses to changes in fruit abundance in such a way that response at the assemblage level cannot be seen as the sum of individual responses of each species. Our results suggest that fruit tracking in frugivorous?insectivorous birds may be largely explained by species-specific responses to changes in the availability of fruits and alternative resources.  5. In agreement with our prediction, more accurate measurements of interaction strength described fruit?frugivore relationships better than traditional measurements. Moreover, we show that covariation between frugivore abundance, frequency of fruit consumption and fruit availability must be included in the fruit-tracking hypothesis framework to demonstrate (or reject) spatiotemporal fruit tracking. We propose that estimation of nutrient and energy availability in fruits could be a new frontier to understanding the forces driving foraging decisions that lead to fruit tracking.","palabras_clave":"FRUGIVORE ASSEMBLAGE|FRUIT-EATING BIRDS|FRUIT TRACKING|RESOURCE TRACKING |SEED DISPERSERS|SOUTHERN YUNGAS FORESTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88729,"idioma_id":4,"titulo":"Disruptions in 24-hour profile of hemodynamic parameters in severe sepsis and septic shock","resumen":"Objective: Circadian disruptions in septic patients, and their relationto clinical outcome, have been described by several researchers.Methods: In this work we performed an individual analysis of hemodynamicvariables (cardiac frequency and mean blood pressure)in three groups of patients: severe sepsis, septic shock and individualshoused in the same intensive care unit by causes other thaninflammation or infection, as controls, during the first and the last24 hours of their permanency in the critical care unit. Results: Althoughthe cosinor analysis showed no difference in the proportionof patients that expressed a statistically significant circadian rhythm,during the first 24 hours, the phase of the variations were disruptedin both septic groups, being almost in anti-phase as compared tocontrol individuals. During the last 24 hours, this variation was presentonly for mean blood pressure. No association of these changescould be related to outcome (surveillance). Conclusion: We concludethat disruptions in circadian rhythms in patients during severestages of sepsis are related to phase better than presence\/absenceof variation, which could be crucial to time scheduled therapies.","palabras_clave":"HEMODYNAMIC PARAMETERS|SEPSIS AND SEPTIC SHOCK|CIRCADIAN|BLOOD PRESSURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88730,"idioma_id":4,"titulo":"How males synchronize their reproductive cycles with females to cope with seasonal climate: An endocrinal and ultrastructural study of Phymaturus zapalensis lizards (Liolaemidae)","resumen":"Phymaturus zapalensis inhabits harsh thermal environments in the steppe of Patagonia, Argentina, characterized by climate conditions that impose constraints on reproduction, providing an appealing model to study the role of steroid hormones in the regulation of seasonal reproductive events. Males of P. zapalensis exhibited a postnuptial spermatogenic cycle with spermiation in mid-spring in synchrony with female ovulation time when mating occurs, followed by testicular recrudescence, but do not show sperm reservoir during hibernation period in winter. Females of P. zapalensis can reproduce annually or biennially. Here, we studied the steroidogenic functions of testicular compartments of P. zapalensis by analysing serum testosterone and ultrastructure related to steroidogenic activity in Sertoli and Leydig cells, as a possible mechanism for the synchronization of male and female reproductive cycles. The testosterone cycle resembles the gonadal cycle in P. zapalensis previously described by morphology and histology of testes. Testosterone concentration is highest in mid-spring and lowest in early summer, with an initial recovery at the beginning of a new spermatogenic cycle in late summer and early autumn. Ultrastructural morphological features indicative of steroidogenic activity in Leydig and Sertoli cells were observed during the spermatogenic cycle. Evidence of temporal asynchrony in steroidogenic activity between compartments were found in males captured in summer and autumn, while synchronous activity was found during mating in spring. Temporal separation of steroidogenic activity serves to synchronize male and female cycles in P. zapalensis and assures the adjustment of reproductive activity to physiological and environmental constraints.","palabras_clave":"Leydig and Sertoli cells|lizard|steroidogenesis|testicular function; testosterone"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88731,"idioma_id":4,"titulo":"Thermal biology of genus Liolaemus: A phylogenetic approach reveals    advantages of the genus to survive climate change","resumen":"The trends of body temperatures in the field (Tb) and preferred body temperatures in the laboratory (Tpref) of the genus Liolaemus relative to reproductive mode, air temperature (Tair), precipitation, latitude, and elevation were studied using phylogenetic comparative analysis. Results were discussed in the framework of the evolution of thermal physiology and vulnerability to global climate change. Reproductive mode affects Tb but not Tpref. Whereas Tb and Tpref showed a significant association with Tair, there was no relationship with latitude or elevation.  In most liolaemids, Tpref is significantly higher than Tair and Tb pointing to a primitive condition of Tpref, probably related to earlier Miocene environments. Phylogenetic trends in the evolution of liolaemid thermal physiology provide a physiological explanation for the lowest rates of observed contemporary climate-forced extinctions and those forecasted under climate warming scenarios up to 2080. Liolaemids have a much higher Tpref than is expected for their environments, especially for viviparous members of the genus, in contrast to other viviparous taxa in the sister family the Phrynosomatidae, which have evolved much lower Tb (and Tpref) and currently experience a much higher rate of climate-forced extinction.","palabras_clave":"FILOGENIA|CLIMÁTICO|TEMPERATURA|SQUAMATA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88732,"idioma_id":4,"titulo":"Inoculation of paddy rice with Azospirillum brasilense and Pseudomonas fluorescens: Impact of plant genotypes on the rhizosphere microbial communities and field crop production.","resumen":"Rice is the third largest global food crop. Traditional practice to achieve maximum yields of rice isassociated with the availability of mineral nitrogen and fertilization. This can lead to pollution ofwaterways. This can be particularly important in paddy rice production in north-eastern Argentina. Biofertilizationor inoculation with plant growth-promoting bacteria (PGPB) is a sustainable alternative foragro-ecosystems. Inoculation of wheat, maize, and soybean is a widespread agricultural practice that hasproved to be efficient in increasing production and promoting nutrition of these crops. This work measuresthe response of three rice cultivars to PGPB inoculation under field conditions with a commercialformulation containing strains of Pseudomonas fluorescens and Azospirillum brasilense. The experiment was performed in a farm plot located near Villa Clara, Entre Ríos. A factorial complete block design withfour replicates was applied. Samples were taken at tillering and physiological maturity. Aerial biomass,grain yield, and its components were determined. Culturable microorganisms were analyzed in rhizospheresamples. Counts of most probable number of microaerophilic, nitrogen-fixing microorganismsand community-level physiological profiles of carbon-source utilization were evaluated at physiologicalmaturity. Also, DNA extraction, nifH gene amplification, and terminal restriction fragment length polymorphism (T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.(T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.was performed in a farm plot located near Villa Clara, Entre Ríos. A factorial complete block design withfour replicates was applied. Samples were taken at tillering and physiological maturity. Aerial biomass,grain yield, and its components were determined. Culturable microorganisms were analyzed in rhizospheresamples. Counts of most probable number of microaerophilic, nitrogen-fixing microorganismsand community-level physiological profiles of carbon-source utilization were evaluated at physiologicalmaturity. Also, DNA extraction, nifH gene amplification, and terminal restriction fragment length polymorphism (T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.(T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.Pseudomonas fluorescens and Azospirillum brasilense. The experiment was performed in a farm plot located near Villa Clara, Entre Ríos. A factorial complete block design withfour replicates was applied. Samples were taken at tillering and physiological maturity. Aerial biomass,grain yield, and its components were determined. Culturable microorganisms were analyzed in rhizospheresamples. Counts of most probable number of microaerophilic, nitrogen-fixing microorganismsand community-level physiological profiles of carbon-source utilization were evaluated at physiologicalmaturity. Also, DNA extraction, nifH gene amplification, and terminal restriction fragment length polymorphism (T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.(T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.nifH gene amplification, and terminal restriction fragment length polymorphism (T-RFLP) analysis were performed to analyze molecular diversity of diazotrophic communitiesassociated with rice roots. Data showed differences between rice genotypes. Inoculation with PGPB didnot have significant impact on culturable microbial communities and patterns of T-RFLP. Some fragmentsobtained by restriction with enzymes HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.HaeIII and HhaI differentiated between inoculation treatments and rice genotypes. PGPB inoculation increased aerial biomass production, harvest index, and grain yield ofthe Supremo 13 cultivar by 4.7%, 16%, and 20.2%, respectively. Inoculation of the Yeruá cultivar increasedaerial biomass by 1.9% and grain yield by 11%. On the other hand, control plants of the Cambá INTA cultivarproduced 8.7% and 7.3% more aerial biomass and grain yield than inoculated plants, respectively.Inoculation reduced the percentage of chaffy grains of the three rice cultivars. The results indicate thatthe combined inoculation with P. fluorescens and A. brasilense has significant potential when applied to rice.rice.P. fluorescens and A. brasilense has significant potential when applied to rice.","palabras_clave":"Oryza sativa|Bacteriaplant interactions|Inoculants|Carbon-level physiological profiles|Microbial diversity|Crop production"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88733,"idioma_id":5,"titulo":"Residuos y utilización de agua durante la producción de piezas en una empresa metalúrgica de Tandil, Argentina","resumen":"Se presenta un estudio acerca de la generación de residuos sólidos y de lautilización de agua de calidad industrial en la Planta de Hierro de unaempresa metalúrgica, radicada en Tandil (Provincia de Buenos Aires,Argentina) productora de piezas fundidas para la industria automotrizmediante el método de fundición por gravedad. Es objetivo del trabajohacer un aporte en mejorar el rendimiento de la cadena productiva.Específicamente, se identifican y clasifican los diferentes tipos de residuosproducidos en las distintas secciones involucradas en el proceso deproducción y se estiman parámetros tales como balance de masa, relaciónporcentual entre cada tipo de residuo y la relación entre residuos totales yproducto final comercializado. En las secciones de la Planta en las que seutiliza agua de calidad industrial, se cuantifica su uso. El análisis de losresultados arroja una correlación entre los diferentes usos del agua ydisposición de algunos de los residuos sujetos a estudio. Sobre la base delos estudios realizados y aplicando un modelo de la bibliografía adaptado ala problemática local, se efectúa una estimación predictiva de lageneración de residuos y consumo de agua.","palabras_clave":"Residuos industriales|Agua de calidad industrial|Balance de masa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88734,"idioma_id":4,"titulo":"Analysis of the interactions between difluoroacetylene and one or two hydrogen fluoride molecules based on calculated spin?spin coupling constants","resumen":"A theoretical study of FCCF:(HF)n complexes, with n = 1 and 2, has been carried out by means of ab initio computational methods. Two types of complexes are formed: those with FH...pi interactions and those with FH...FC hydrogen bonds. The indirect spin?spin coupling constants have been calculated at the CCSD\/aug-cc-pVTZ-J computational level. Special attention has been paid to the dependence of the different intramolecular coupling constants in FCCF on the distance between the coupled nuclei and the presence or absence of the hydrogen fluoride molecule. The sensitivity shown by these coupling constants to the presence of hydrogen fluoride is quite notorious.","palabras_clave":"Hydrogen bond |Indirect nuclear spinspin coupling constants |NMR |CCSD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88735,"idioma_id":4,"titulo":"Phytochrome B increases drought tolerance enhancing ABA sensitivity in Arabidopsis thaliana","resumen":"  Phytochrome B (phyB) can adjust morphological and physiological responses according to changes in the red : far-red (R:FR) ratio. phyB-driven acclimation of plants to open environments (high R:FR ratio) increases carbon gain at the expense of increased water loss. This behaviour alleviates stressful conditions generated by an excess of light, but increases the chances of desiccation. Here we evaluated how phyB modulates this droughttolerance response by comparing wild-type Arabidopsis thaliana adult plants to the null phyB in response to water shortage. phyB wilted before the wild type, and this was due to phyB maintaining open stomata under a reduction in soil water availability. Although phyB presented enhanced ABA levels under well-watered conditions, this mutant was less sensitive than the wild type in diminishing stomatal conductance in response to exogenous ABA application. Reduced sensitivity to ABA in phyB correlated with a lower expression of ABCG22, which encodes a putative ABA influx transporter, and PYL5, which encodes a soluble ABA receptor. Furthermore, the expression of RAB18 and RD29A, both typical ABA-induced genes, was lower in phyB than the wild type after ABA treatment.We propose that phyB contributes to the acclimation of plants to open environments by enhancing ABA sensitivity when soil water becomes limiting. ","palabras_clave":"R:FR RATIO|WATER RELATIONS|ABA SIGNALING ELEMENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88736,"idioma_id":4,"titulo":"Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles","resumen":"The ability of cells to acquire resistance to multiple pharmaceuticals, namely multidrug resistance (MDR), is often mediated by the over-expression of efflux transporters of the ATP-binding cassette (ABC) superfamily; for example P-glycoprotein (P-gp or MDR1), breast cancer resistance protein (BCRP or ABCG2), and multidrug resistance-associated protein MRP1. ABCs pump drug molecules out of cells against a concentration gradient, reducing their intracellular concentration. The ability of polymeric amphiphiles to inhibit ABCs as well as the cellular pathways involved in the inhibition has been extensively investigated.This work investigated for the first time the effect of branched poly(ethylene oxide)-poly(propylene oxide) block copolymers (poloxamines) on the levels of mRNA encoding for MDR1, BCRP and MRP1, in a human hepatoma cell line (Huh7). Copolymers with a broad range of molecular weights and hydrophilic- lipophilic balances were assayed. Results confirmed the down-regulation of mdr1 and abcg2 genes. Conversely, the mrp1 gene was not affected. These findings further support the versatility of these temperature-and pH-responsive copolymers to overcome drug resistance in cancer and infectious diseases.","palabras_clave":"poloxamines|mdr1|abcg2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88737,"idioma_id":4,"titulo":"Structure and composition of a thrips community in the Chihuahua Desert, New Mexico, U.S.","resumen":"We examined plant used versus plant availability by a thysanopteran community on 13 woody and perennial native plants in the Chihuahua Desert. Individual plants were sampled with sticky-traps on 8 dates from May 1997 to August 1998. We sampled 5,040 adult thrips from 26 species in 19 genera, of which 16 could be identified to species. Four families were represented, Thripidae (17 species comprised 98.2 % of the collected specimens), Phlaeothripidae (5 species comprised 1.6%), Aeolothripidae (2 species comprised 0.1%) and Heterothripidae (1 species comprised 0.1%). A total of 16 species (84.2%) were phytophagous on flowers and leaves, 2 (10.5%) were predators, one (5.2%) was mycophagous. Feeding habits for 7 species are unknown. Thrips abundance was positively correlated with plant volume, but not with insect richness. Strikingly for a natural area, Frankliniella occidentalis accounted for 73.6% of the total collection of the sampled thrips, which together with Chirothrips falsus, Microcephalothrips abdominalis, Frankliniella gossypiana, and Neohydatothrips signifier, comprised 94.0% of the total number of collected thrips. Main abundances, considering all thrips species, occurred in fall and spring; no thrips were collected during winter. This seasonal pattern of occurrence was observed for the most abundant thrips species. In summary, the results of this study were: 1) few thrips species were found to be specialists; only 2 thrips species out of 12 studied, showed strong preference for host plants, 2) presence of a high percentage of positive associations, and a low percentage of negative associations, 3) the role of plant volume explained more than 80% of variance of thrips abundance. These results suggest that the studied thrips community has low plant specificity and the pattern of plant use observed could be the consequence of generalist feeding diets.  Examinamos el uso de plantas versus la disponibilidad de plantas de una comunidad de Thysanoptera sobre 13 plantas nativas (leñosas y perennes) en el desierto de Chihuahua. Se muestrearon plantas individuales con trampas pegajosas en 8 fechas desde de mayo de 1997 hasta agosto de 1998. Se obtuvieron 5.040 trips adultos pertenecientes a 26 especies en 19 géneros, de los cuales 16 se pudo identificar hasta especie. Cuatro familias están representadas, Thripidae (17 especies que representaron el 98,2% de los especímenes recolectados), Phlaeothripidae (5 especies que constituyeron 1,6%), Aeolothripidae (2 especies que constituyeron el 0,1%) y Heterothripidae (1 especie que correspondió al 0,1%). Un total de 16 especies (84,2%) fueron fitófagos (en flores y hojas), 2 (10,5%) fueron depredadores, uno (5,2%) fue micófago. De 7 especies se desconocen sus hábitos alimentarios. La abundancia de trips se correlacionó positivamente con el volumen de las plantas, no así con la riqueza. Sorprendentemente para un área natural, Frankliniella occidentalis representó el 73,6% de la recolección total de los trips, que junto con Chirothrips falsus, Microcephalothrips abdominalis, Frankliniella gossypiana, y Neohydatothrips signifer, representaron 94,0% del total recogido. La mayor abundancia de trips se produjo en otoño y primavera, y no se recolectaron trips en el invierno. Este patrón estacional de ocurrencia se observó para las especies de trips más abundante. En resumen, los resultados de este estudio fueron: 1) presencia de pocas especies de trips fueron especialistas, sólo dos especies de trips de los 12, mostraron una clara preferencia por sus plantas hospedantes, 2) presencia de un alto porcentaje de asociaciones positivas, y un bajo porcentaje de asociaciones negativas, 3) el rol del volumen de plantas que explica más del 80% de la varianza de la abundancia de trips. Estos resultados sugieren que la comunidad trips estudiado tiene una baja especificidad y el patrón de utilización de las plantas es consecuencia de una dieta alimentaria generalista.","palabras_clave":"Thysanoptera|insect-plant association|desert plant"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88738,"idioma_id":4,"titulo":"Glass wool filtration of bull cryopreserved semen: a rapid and effective method to obtain a high percentage of functional spermatozoa","resumen":"Frozen-thawed bull sperm are widely used in assisted reproductive technologies, but cryopreservation negatively affects semen quality. Several sperm selection techniques have been developed to separate motile sperm from non-motile cells. The aim of the present study was to evaluate the effectiveness of the glass wool column filtration to select functional sperm from frozen-thawed bull semen samples. Frozen semen from six Holstein bulls was thawed and filtered through a glass wool column, followed by assessment of routine and functional sperm parameters. In a set of experiments, sperm aliquots were also processed by swim up to compare both selection methods. Samples recovered in the glass wool filtrate had high percentages of viable (94 ± 3%, mean ± SD), progressively motile (89 ± 4%), acrosome-intact (98 ± 1%), and non-capacitated (80 ± 10%) sperm; these values were higher (P &lt; 0.05) than those obtained after performing the swim up procedure. Moreover, the glass wool filtration yielded 67 ± 19% motile cells, in comparison with 18 ± 8% obtained with swim up (P &lt; 0.05), calculated as the concentration of progressively motile cells selected relative to their concentration in the sample before the selection procedure. Glass wool-filtered sperm were able to undergo capacitation-related events, based on the increase in the percentage of cells classified as capacitated by CTC staining (B-pattern) after incubation with heparin (50 ± 5%) in comparison with control conditions with no heparin (17 ± 4%) or heparin + glucose (16 ± 2%; P &lt; 0.05). Moreover, they underwent acrosomal exocytosis in response to pharmacologic (calcium ionophore A23187 and lysophosphatidylcholine) and physiological (follicular fluid) stimuli, and they fertilized in vitro matured cumulus-oocyte complexes and denuded oocytes (two-cell embryos: 72 ± 4% and 52 ± 6%, respectively). We conclude that glass wool filtration is a low-cost, simple, and highly effective procedure to select functionally competent sperm for reproductive technologies in the bull, which may be useful for other domestic and farm animals, as well as for endangered species.","palabras_clave":"BOVINE|SPERM|GLASS WOOL|CAPACITATION|ACROSOMAL EXOCYTOSIS|IN VITRO FERTILIZATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88739,"idioma_id":5,"titulo":"Eficaz selección de espermatozoides bovinos criopreservados usando filtración por columnas de lana de vidrio","resumen":"La criopreservación del semen es ampliamente utilizada en el manejo reproductivo bovino y permite la distribución y comercialización del material genético de esta especie. Sin embargo, los protocolos de congelación\/descongelación afectan negativamente la calidad espermática, originando una alta proporción (más del 50%) de espermatozoides muertos y criocapacitados, no aptos para la fecundación. Para obtener espermatozoides funcionales es necesario realizar procedimientos de selección espermática. Recientemente hemos publicado un trabajo en la revista Theriogenology (2012; 78:201-209) que describe el uso de la filtración por columnas de lana de vidrio para la selección de espermatozoides funcionales a partir de semen bovino previamente congelado. El método es rápido, sencillo y económico, y permite seleccionar un alto porcentaje de espermatozoides vivos (94±3%), con motilidad progresiva (89±4%), no capacitados (80±10%), con el acrosoma intacto (98±1%) y que presentan alta capacidad de fecundar ovocitos in vitro. La técnica de filtración permite obtener un rendimiento del 67±19 %, ~4 veces mayor que el del método de Swim up. En conclusión, la filtración por columnas de lana de vidrio es una alternativa válida para las biotecnologías reproductivas bovinas, así como para otros animales domésticos y de granja y para especies en peligro de extinción.","palabras_clave":"SELECCION ESPERMATICA|LANA DE VIDRIO|CAPACIDAD FECUNDANTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88740,"idioma_id":4,"titulo":"DNA barcoding and morphological identification of Argentine species of Apanteles (Hymenoptera : Braconidae), parasitoids of cactus-feeding moths (Lepidoptera : Pyralidae : Phycitinae), with description of a new species","resumen":"The gregarious species of Apanteles that attack cactus-feeding phycitine moths (Lepidoptera : Pyralidae) from Argentina are identified usingDNAbarcodes and morphological data. Sequences of specimens from 10 different populations were generated. Corrected genetic divergences showed two clusters of specimens separated by COI divergences higher than 6%. Our morphological examinations were congruent with the molecular evidence and therefore two species were confidently identified: Apanteles alexanderi Brèthes and a new species, Apanteles opuntiarum Martínez &amp; Berta, sp. nov., which we describe and illustrate. Despite these two taxa being considered to represent a single polyphagous species for at least 50 years, they can be easily distinguished by the length of their ovipositor sheaths.Akey to the species of microgastrine parasitoids of cactus-feeding Lepidoptera in South America is provided. The recognition of the new species reveals a narrower host range for the species involved in this system, making it necessary to re-evaluate their potential as biocontrol agents of the prickly pear moth","palabras_clave":"Apanteles alexanderi|Apanteles opuntiarum|biological control|Cactoblastis cactorum|COI|Opuntia|prickly pear"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88741,"idioma_id":4,"titulo":"Proconiini Sharpshooters of Argentina, with notes on its distribution, host plants, and natural enemies","resumen":"The American tribe Proconiini (Hemiptera: Cicadellidae: Cicadellinae) is one of the largest groups of xylem-feeding insects and includes the majority of the known vectors of xylem-born phytopathogenic organisms. The significance of the pathogens that this group transmits gives them an important role as pests, mostly for citrus fruit, grapes, and almonds. Knowledge of&nbsp; hese Hemiptera in Argentina is insufficient and fragmentary. Thus one of the aims of this paper is to summarize the available information of the Proconiini sharpshooters in Argentina. In addition, 14 species are mentioned for the first time in the country, and new distributional data are given for 18 species. Thirty-four new associations between sharpshooters and host plants are recorded. New records of egg parasitoids are given for Dechacona missionum, Molomea consolida, M. lineiceps, and Tapajosa similis.Dechacona missionum, Molomea consolida, M. lineiceps, and Tapajosa similis.","palabras_clave":"AUCHENORRHYNCHA|CICADELLIDAE|BIONOMICS|PARASITOIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88742,"idioma_id":4,"titulo":"Oxidative damage and antioxidant response of Allium cepa meristematic and elongation cells exposed to Metronidazole","resumen":"The toxicity of metronidazole (MTZ) in meristematic and elongation zones of Allium cepa roots was analyzed for 30 hours of exposition. Toxic effects were evaluated by lipid peroxidation (content of thiobarbituric reactive substances -TBARS-), reduced glutathione (GSH) levels, ascorbate acid (AA) and dehydroascorbate acid (DHA) content and enzymatic activities of superoxide dismutase (SOD) and catalase (CAT). The root zones showed differentiated susceptibility to MTZ. In the elongation zone, MTZ induced an increase of TBARS content, and a significant rise in GSH levels, whereas in the meristematic zone, lipid peroxidation was not observed and all antioxidant defense parameters analyzed were significantly incremented. These results indicate that MTZ exposure induced oxidative stress in A. cepa roots, and the antioxidant defenses in the meristematic zone are more efficient in comparison to the elongation zone, which is probably related to higher oxidative metabolism of meristematic tissue.","palabras_clave":"METRONIDAZOLE|ALLIUM CEPA |OXIDATIVE STRESS |ANTIOXIDANT DEFENSES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88743,"idioma_id":4,"titulo":"Use of Genetic and Behavioural Analysis in the Captive Management of Night Monkeys Aotus azarae (Platyrrhini: Cebidae).","resumen":"Zoological gardens provide unique and valuable resource for primate research. Knowledge on acclimatizing and behavioral pattern of night monkeys (Aotus azarae) in captivity is scarce. Here, we aim to characterize the activity budget of a group of Aotus azarae housed at the Córdoba Zoo, Argentina. The taxonomic level of the specimens was confirmed by karyological analysis using different chromosomal variables. Behavioral data were collected via scan sampling, recording eight behavioral categories. The main activity of the group was resting. Social behavior was influenced by the moment of the day. The obtained activity budget will allow establishing a baseline for future management and environmental enrichment plans.","palabras_clave":"CAPTIVE MANAGEMENT|AOTUS|GENETICS|BEHAVIOUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88744,"idioma_id":4,"titulo":"Baseline values of Micronuclei and Comet Assay in the lizard Tupinambis merianae (teiidae Squamata)","resumen":"The Micronucleus test (MN) and Comet assay (CA) are currently the most widely used methods that allow the characterization of DNA damage induced by physical and chemical agents in wild species. The continuous expansion of the cultivated areas in Argentina, since the introduction of transgenic crops, mainly soy, in association with the increased use of pesticides, transformed deeply the natural environments where the lizard Tupinambis merianae (tegu lizard) occurs. Despite the fact that reptileshave shown to be excellent bioindicators of environmental contaminants, there is no record of genotoxicity studies in T. merianae. The aim of the present study was to adjust the MN test and CA protocols to be applied in erythrocytes of T. merianae, and determine the baseline values of DNAdamage in this species. We used 20 adult lizards (10 males: 10 females) from Estacio´n Zoolo´ gica Experimental \u2018\u2018Granja La Esmeralda\u2019\u2019 (Santa Fe, Argentina). Peripheral blood samples were collected from all animals and the MN test and CA applied according to the protocols established for other reptilian species. We test critical parameters of CA protocol (cell density, unwinding and electrophoresis times) using increasing concentrations of H2O2 (10, 25 and 50 mM) as a known genotoxic agent toinduce DNA damage. Based on this, we determined the most suitable conditions for the CA in this species: a cell density of 4103 erythrocytes per slide, 10 min of unwinding and 15 min of electrophoresisat 0.90 V\/cm approximately. The baseline frequency of micronuclei (BFMN¼MN\/1000 erythrocytes counted) determined for this species was 0.9570.27 and the basal damage index (BDI: calculated from 100 comet images classified in arbitrary units)¼103.8570.97. No differenceswere observed between sexes in the BFMN or BDI (p40.05), and no relation was found between baseline values and length or weight of the analyzed animals (p40.05). These results demonstrated the sensitivity of both biomarkers of genotoxicity to be applied in erythrocytes of this species, with baseline values comparable to those reported in other reptilian species. These results allow us to propose the tegu lizard for future in vivo studies to assess the genotoxicity of different agents, including those possibly affecting it in its natural geographic distribution.","palabras_clave":"TEGU LIZARD|GENOTOXICITY|SENTINEL SPECIES|REPTILES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88745,"idioma_id":4,"titulo":"INTESTINAL PARASITES OF Alouatta caraya  (PRIMATES, CEBOIDEA): PRELIMINARY STUDY IN  SEMI-CAPTIVITY AND IN THE WILD IN ARGENTINA","resumen":"Endoparasitic infections are common in nonhuman primates and important factors in regulating their natural populations. Primates are particularly vulnerable to the infections of directly transmitted parasites because they often live in close social groups that facilitate their transmission. The main objective of this study was to provide baseline data on gastrointestinal parasites of semi captive and wild howler monkeys Alouatta caraya troops from Argentina. We collected 110 fecal samples from 38 howler monkeys from four troops, two of them kept in semi-captivity at the CRMAN, Córdoba, and two wild troops from Las Lomas, Corrientes. We identified six species of parasites: four Protozoa, Giardia lamblia, Blastocystis hominis, Eimeria sp. and Entamoeba coli; one Cestoda, Bertiella mucronata and one Nematoda, Strongyloides sp. Of the individuals sampled, 86.8% harbored at least one type of gastrointestinal parasite. Protozoa were found in 78.9% of hosts and helminths in 21.1%. We found significant differences in the prevalence of three protozoan species between study sites; and howlers from Las Lomas showed the highest prevalence. The differences found may be related to environmental conditions, where warmer and wetter regions (Las Lomas) favor the survival of infectious stages of some parasitic species.","palabras_clave":"Alouatta caraya|Argentina|Helminths|Protozoa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88746,"idioma_id":4,"titulo":"A New World Monkey microsatellite (AP74) higly conserved in Primates","resumen":"Given their great variability, microsatellites or STRs became the most commonly used genetic markers over the last 15 years. The analysis of these markers requires minimum quantities of DNA, allowing the use of non invasive samples, such as feces or hair. We amplified the microsatellite Ap74 in blood and hair samples in order to analyze the levels of genomic conservation among a wide range of primates including: Lemur catta, Alouatta caraya, Ateles belzebuth, Ateles chamek, Pan troglodytes, Papio sp., and Homo sapiens. In all cases we obtained amplification products that exhibited similar size both in monkeys and human (oscillating between 126 and 176 bp), except in the lemur where the detected fragment presented a size of approximately 1000 bp. The analysis of the nucleotide sequences permitted the evaluation of the molecular modifications experienced during the evolutionary process in primates.","palabras_clave":"PRIMATES|MICROSATELLITE MARKERS|PCR AMPLIFICATION|NON INVASIVE SAMPLING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88747,"idioma_id":5,"titulo":"ALOUATTA CARAYA: NUEVO SITIO DE ESTUDIO EN ARGENTINA.","resumen":"Dentro de la familia Atelidae, los monos aulladores (géneroAlouatta) tienen una de las distribuciones geográficas másamplias, extendiéndose desde el sur de México hasta elnorte de Argentina (Crockett y Eisenberg, 1987; Zuninoet al., 2001). Groves (2001; 2005) reconoce 10 especiespara el género. De éstas especies dos llegan a la RepúblicaArgentina: Alouatta guariba clamitans y Alouatta carayaHumboldt, 1812 (Cabrera, 1939). Alouatta caraya poseeuna amplia distribución en Sudamérica, en Argentina, ellímite sur de su distribución, se encuentra al Este de Formosay Chaco, NE de Santa Fe, el centro de Corrientes yMisiones (Brown y Zunino, 1994).A finales del 2008 se realizaron salidas de campo a unnuevo sitio de estudio conocido como: ?Las Lomas?, (27°23' S; 58° 22' O), campo privado de 623 ha en la localidadde San Cosme, Provincia de Corrientes, Argentina(Fig. 1). La temperatura media anual es 21°C y las precipitacionesmedias anuales son de 1,200 mm. Allí se constatóla presencia de varias tropas de aulladores. Según Cabrera(1976) y Carnevali (1994) forma parte del DistritoOriental Chaqueño, Sub-distritos: ?Correntino?, a su vezdividido en ?Parque Chaqueño Correntino? (sector Noroeste).El Chaco Oriental está compuesto por un mosaicode bosques, palmares, pastizales, pajonales y esteros. Las especiesmás características de estos bosques los quebrachos(Schinopsis spp), el urunday (Astronium balansae), y el viraró(Ruprechtia laxiflora). En las zonas más bajas se desarrollanbosques de algarrobos (Prosopis spp) acompañados de talas(Celtis spinosa) y palmeras caranday (Trithrinax sp). Enforma de isletas de monte aparecen especies vegetales típicascomo el alecrín (Holocalyx balansae), la palmera pindó(Syagrus romanzoffiana), el timbó (Canthormion sp) y ellaurel (Nectandra spp) (Burkart et al, 1999).","palabras_clave":"Alouatta caraya|Corrientes|comportamiento|parasitología"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88748,"idioma_id":4,"titulo":"Extended Geographical Distribution and Host Range of the Cactus Moth, Cactoblastis cactorum (Lepidoptera: Pyralidae), in Argentina","resumen":"A field exploration was conducted to confirm  the southern distribution of Cactoblastis cactorum  in Argentina. The distribution of the moth was  found to be extended to the south (40° 10´S) and  west (66° 56´W). The native species Opuntia penicilligera  was recorded as a host for the first time.  These findings should be useful in improving bioclimatic  models to predict the potential geographic  range of C. cactorum in North America.","palabras_clave":"Cactoblastis cactorum|geographic distribution|Argentina|Opuntia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88749,"idioma_id":5,"titulo":"El marxismo y la burocracia sindical. La experiencia alemana (1898-1920)","resumen":"Este trabajo reseña las polémicas llevadas a cabo por el ala revolucionaria de la socialdemocracia alemana contra el reformismo de los dirigentes sindicales ligados al partido, particularmente en torno a la consigna de la huelga política de masas, levantada como resultado de la Revolución Rusa de 1905. El artículo describe también el rol de dichos dirigentes en la conformación del ala de centro liderada por Karl Kautsky a partir de 1910, en el abandono del internacionalismo en 1914 y en la consolidación de un régimen de contrarrevolución democrática en Alemania, a partir de noviembre de 1918. Se demuestra cómo la burocracia sindical y partidaria desarticuló políticamente a la clase obrera alemana, sentando así las bases para dos de las más grandes derrotas históricas del proletariado mundial: el colapso de la Segunda Internacional y el fracaso de la Revolución Alemana de 1918-231.","palabras_clave":"HISTORIA DEL MARXISMO|BUROCRACIA SINDICAL|SOCIALDEMOCRACIA ALEMANA|SEGUNDA INTERNACIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88750,"idioma_id":4,"titulo":"An interval fuzzy model for magnetic monitoring: estimation of a pollution index","resumen":"In this contribution, a methodology is reported in order to build an   interval fuzzy model for the pollution index PLI (a composite              index using relevant heavy metal concentration) with   magnetic parameters as input variables. In general, modelling based on              fuzzy set theory is designed to mimic how the human brain   tends to classify imprecise information or data. The interval fuzzy              model reported here, based on fuzzy logic and arithmetic of   fuzzy numbers, calculates an estimation interval and seems              to be an adequate mathematical tool for this nonlinear   problem. For this model, fuzzy c-means clustering is used to   partition data, hence the membership functions and rules are built. In   addition, interval arithmetic              is used to obtain the fuzzy intervals. The studied sets are   different examples of pollution by different anthropogenic sources,              in two different study areas: (a) soil samples collected in   Antarctica and (b) road-deposited sediments collected in Argentina.              The datasets comprise magnetic and chemical variables, and   for both cases, relevant variables were selected: magnetic   concentration-dependent              variables, magnetic features-dependent variables and one   chemical variable. The model output gives an estimation interval;              its width depends on the data density, for the measured   values. The results show not only satisfactory agreement between the              estimation interval and data, but also provide valued   information from the rules analysis that allows understanding the   magnetic              behaviour of the studied variables under different   conditions.","palabras_clave":"FUZZY-C-MEANS CLUSTERING|INTERVAL FUZZY MODEL|MAGNETIC MONITORING|POLLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88751,"idioma_id":4,"titulo":"Proton and calcium-gated ionic mesochannels: phosphate-bearing polymer brushes hosted in mesoporous thin films as biomimetic interfacial arch itectures","resumen":"ABSTRACT: Rational construction of interfaces based on multicomponentresponsive systems in which molecular transport ismediated by structures of nanoscale dimensions has become a veryfertile research area in biomimetic supramolecular chemistry.Herein, we describe the creation of hybrid mesostructuredinterfaces with reversible gate-like transport properties that canbe controlled by chemical inputs, such as protons or calcium ions.This was accomplished by taking advantage of the surface-initiatedpolymerization of 2-(methacryloyloxy)ethyl phosphate (MEP)monomer units into and onto mesoporous silica thin films. Inthis way, phosphate-bearing polymer brushes were used as\u201Cgatekeepers\u201D located not only on the outer surface of mesoporousthin films but also in the inner environment of the porous scaffold.Pore-confined PMEP brushes respond to the external triggering chemical signals not only by altering their physicochemicalproperties but also by switching the transport properties of the mesoporous film. The ion-gate response\/operation was based onthe protonation and\/or chelation of phosphate monomer units in which the polymer brush works as an off-on switch in responseto the presence of protons or Ca2+ ions. The hybrid meso-architectured interface and their functional features were studied by acombination of experimental techniques including ellipso-porosimetry, cyclic voltammetry, X-ray reflectivity, grazing incidencesmall-angle X-ray scattering, X-ray photoelectron spectroscopy, and in situ atomic force microscopy. In this context, we believethat the integration of stimuli-responsive polymer brushes into nanoscopic supramolecular architectures would provide newroutes toward multifunctional biomimetic nanosystems displaying transport properties similar to those encountered in biologicalligand-gated ion channels.","palabras_clave":"THIN FILMS|POLYMER BRUSHES|IONIC MESOCHANNELS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88752,"idioma_id":4,"titulo":"Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor","resumen":"Rhizobium leguminosarum is a soil bacterium that infects root hairs and induces the formation of nitrogen-fixing nodules on leguminous plants. LOV- (Light, Oxygen and Voltage) domain proteins are blue-light receptors found in higher plants and many algae, fungi, and bacteria. The genome of R. leguminosarum bv. viciae 3841, a pea-nodulating endosymbiont, encodes a sensor histidine kinase containing a LOV domain at the N-terminal end (R-LOV-HK). R-LOV-HK has a typical LOV domain absorption spectrum with broad bands in the blue and UV-A region and shows a truncated photocycle. Here we show that the R-LOV-HK protein regulates attachment to an abiotic surface, and production of flagellar proteins and exopolysaccharide in response to light. Also, illumination of bacterial cultures prior to inoculation of pea roots&nbsp;increases the number of nodules per plant and the number of intranodular bacteroids. The effects of light on nodulation are dependent on a functional lov gene. The results presented in this work suggest that light, sensed by R-LOV-HK, is an important environmental factor that controls adaptive responses and the symbiotic efficiency of R. leguminosarum.","palabras_clave":"RHIZOBIUM LEGUMINOSARUM|LOV-HISTIDINE KINASE PHOTORECEPTOR|LIGHT|REGULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88753,"idioma_id":5,"titulo":"Adsorción en la Vida Cotidiana. Un Experimento de Fisicoquímica con Aplicación Ambiental","resumen":"Este trabajo presenta un enfoque innovador para estudiar el fenómeno de adsorción teniendo en cuenta la perspectiva ambiental. En este contexto se estudiaron las fisisorciones de dos sustancias comunes, ácido acético e hipoclorito de sodio, sobre carbón activado como un caso típico de tratamiento de contaminantes en fase acuosa. Para ello se estudiaron las cinéticas y las isotermas de adsorción a temperatura ambiente. Estos experimentos involucran una serie de técnicas básicas de laboratorio, como las titulaciones ácido-base y redox, el tratamiento de datos,su representación gráfica y el ajuste de los resultados experimentales con los modelos de adsorción de Langmuir y de Freundlich. Se muestra finalmente que el trabajo experimental permite que los alumnos adquieran habilidades de laboratorio de química con experimentos simples.","palabras_clave":"ENSEÑANZA DE LA QUIMICA|QUIMICA EXPERIMENTAL|ADSORCIÓN|CINÉTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88754,"idioma_id":4,"titulo":"Two Novel Mutations in the Thyroglobulin Gene as Cause of Congenital Hypothyroidism. Identification a Cryptic Donor Splice Site in the Exon 19.","resumen":"Thyroglobulin (TG) is a homodimeric glycoprotein synthesized by the thyroid gland. To date, fifty-two mutations of the TG gene have been identified in humans. The purpose of the present study was to identify and characterize new mutations in the TG gene. We report a French patient with congenital hypothyroidism, mild enlarged thyroid gland and low levels of serum TG. Sequencing of DNA, genotyping, expression of chimeric minigenes as well as bioinformatics analysis were performed. DNA sequencing identified the presence of compound heterozygous mutations in the TG gene: the paternal mutation consists of a c.3788-3789insT or c.3788dupT, whereas the maternal mutation consists of g.IVS19+3_+4delAT. Minigen analysis of the g.IVS19+3_+4delAT mutant showed that the exon 19 is skipped during pre-mRNA splicing or partially included by use of cryptic 5´splice site located to 100 nucleotides downstream of the wild type exon-intron junction. The c.3788-3789insT mutation results in a putative truncated protein of 1245 amino acids, whereas g.IVS19+3_4delAT mutation originates two putative truncated proteins of 1330 and 1349 amino acids. In conclusion, we show that the g.IVS19+3_+4delAT mutation promotes the activation of a cryptic donor splice site in the exon 19 of the TG gene. These results open up new perspectives in the knowledge of the mechanism of splicing for the TG pre-mRNA. ","palabras_clave":"CONGENITAL GOITER|THYROGLOBULIN GENE|MUTATION|COMPOUND HETEROZYGOUS MUTATION|CRYTIC SPLICE SITE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88755,"idioma_id":4,"titulo":"Congenital goitrous hypothyroidism:  mutation analysis in the thyroid peroxidase gene","resumen":"Background Iodide organification defect (IOD) is characterized by a reduced ability of the thyroid gland to retain iodide resulting in hypothyroidism. Mutations in thyroid peroxidase (TPO) gene appear to be the most common cause of IOD and are commonly inherited in an autosomal recessive fashion. The TPO gene is located on the chromosome 2p25. It comprises 17 exons, covers approximately 150 kb of genomic DNA and codes 933 amino acids. Objetives In this study, we characterize the clinical and molecular basis of seven patients from four unrelated families with congenital hypothyroidism (CH) because of IOD. Design and Methods All patients underwent clinical, biochemical and imaging evaluation. The promoter and the complete coding regions of the human TPO along with the flanking intronic regions were analysed by single-strand conformation polymorphism analysis and direct DNA sequencing. Segregation analysis of mutations was carried out, and the effect of the novel missense identified mutations was investigated by 'in silico' studies. Results All subjects had congenital and persistent primary hypothyroidism. Three novel mutations: c.796C&gt;T [p.Q266X], c.1784G&gt;A [p.R595K] and c.2000G&gt;A [p.G667D] and a previously reported mutation: c.1186_1187insGGCC [p.R396fsX472] have been identified. Four patients were compound heterozygous for p.R396fsX472\/p.R595K mutations, two patients were homozygous for p.R595K, and the remaining patient was a compound heterozygous for p.Q266X\/p.G667D. Conclusions Our findings confirm the genetic heterogeneity of TPO defects and the importance of the implementation of molecular studies to determinate the aetiology of the CH with dyshormonogenes. ","palabras_clave":"CONGENITAL GOITER|HYPOTHYROIDISM|THYROID PEROXIDASE|MUTATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88756,"idioma_id":4,"titulo":"Variable clinical presentation and outcome in pediatric patients with resistance to thyroid hormone (RTH)","resumen":"Resistance to thyroid hormone (RTH) is characterized by elevated levels of thyroid hormones, normal or slightly increased TSH levels respondent to TRH, resistance to thyroid hormone administration, and variable clinical expression. To describe the diverse clinical and biochemical findings of six children from five unrelated families with molecular diagnosis of RTH (0.5-12.7 years) and their follow-up (3-20 years). All RTH patients and 4 affected parents' harbored mutations in exons 9 or 10 of the thyroid receptor b gene: p.M313T (de novo), pN331D, p.L341P, p.L346F, and p.P453L. At consultation 5\/6 had goiter, 4\/6 tachycardia, and 3\/5 learning disabilities. Median hormone levels were: T4 257.4 nmol\/l (NR: 77.2-180.2); FreeT4 39.9 pmol\/(NR:10.3-28.3); T3 4.28 nmol\/l (NR:1.23-3.39) TSH 2.8 mUI\/l (NR: 0.5-5) always responsive to TRH. TSH levels remained detectable after supraphysiologic T3 administration while SHBG levels showed a paradoxical decrease in 4\/6. Thyroid antibodies, initially present in two subjects, became positive in other two during follow-up. All patients grew normally and presented variable symptoms that were treated according to need. Two patients developed psychiatric disorders. Only one of the four affected parents exhibited clinical signs of RTH (tachycardia and depression). Parent´'s thyroid profile showed similar TSH and T3 levels but lower T4 and FT4 than their children. RTH has a distinctive biochemical profile with highly variable clinical manifestations and outcomes. Its recognition and molecular characterization avoid misleading diagnosis. Treatment has to be instituted according to each subject?s own clinical requirements.","palabras_clave":"Thyroid hormone resistance  |Pediatric patients   |TSH   |Outcome|TRB gene"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88757,"idioma_id":4,"titulo":"The diverse Cretaceous neobatrachian fauna of South America: Uberabatrachus carvalhoi, a new frog from the Maastrichtian Marília Formation, Minas Gerais, Brazil","resumen":"Herein we report on a new anuran genus and species, Uberabatrachus carvalhoi, fromexposures of the Marília Formation (Maastrichtian) at the well-known fossil site ?Ponto 1 doPrice? near Peirópolis, Uberaba, Brazil. The holotype consists of an articulated partial skeleton characterized by a broad, well-ossified skull lacking dermal ornamentation, eightprocoelous presacral vertebrae, and posteriorly deflected, cylindrical sacral diapophyses;these features, together with the possible presence of a discrete palatine, are consistent withneobatrachian affinities. It clearly differs from the neobatrachian Baurubatrachus, also fromthe Marília Formation, in having a skull lacking exostosis and with a different temporal architecture, among other features. It also differs from the still unnamed neobatrachian recovered from the Adamatina Formation in the presence of paired frontoparietals with narrow supraorbital flanges in the anterior orbital region and maxilla-squamosal contact. Thenew frog is not referable to any of the neobatrachian taxa known from the Aptian?AlbianCrato Formation owing to different cranial features (e.g., position of the jaw articulation,relative width of the braincase, and morphology of the frontoparietal). With respect to theextant neobatrachians in the context of recent phylogenetic hypotheses, the cylindrical sacraldiapophyses of Uberabatrachus contrast with the dilated diapophyses occurring inaustralobatrachian hyloids and microhyloid ranoids, whereas the procoelous presacral column is unlike the diplasiocoelous condition of most other ranoids. This evidence together with the combination of features of Uberabatrachus suggests a placement among nobleobatrachian hyloids, although this combination is not shared with any extant or extinct species for which skeletal information is known. From the foregoing we conclude that Uberabatrachus represents a new nobleobatrachian taxon, a record that reinforces the hypothesis of a diversified neobatrachian fauna in South America by the Cretaceous and is consistent with the previous proposal that neobatrachian early diversification is related to the breakup of Gondwana.","palabras_clave":"ANURA|HYLOIDES|NOBLEOBATRACHIA|MAASTRICHTIAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88758,"idioma_id":4,"titulo":"A basal sphenodontian (Lepidosauria) from the Jurassic of Patagonia: New insights on the phylogeny and biogeography of Gondwanan rhynchocephalians","resumen":"NA","palabras_clave":"ESFENODONTES|JURASICO|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88759,"idioma_id":4,"titulo":"Estrogens induce expression of membrane-associated estrogen receptor &#945; isoforms in lactotropes","resumen":"Abstract                    Estrogens are key to anterior pituitary function, stimulating hormone   release and controlling cell fate to achieve pituitary dynamic adaptation to   changing physiological conditions. In addition to their classical mechanism of   action through intracellular estrogen receptors (ERs), estrogens exert rapid   actions via cell membrane-localized ERs (mERs). We previously showed that E2   exerts a rapid pro-apoptotic action in anterior pituitary cells, especially in   lactotropes and somatotropes, through activation of mERs. In the present study,   we examined the involvement of mER&#945; in the rapid pro-apoptotic action of   estradiol by TUNEL in primary cultures of anterior pituitary cells from   ovariectomized rats using a cell-impermeable E2 conjugate (E2-BSA) and an ER&#945;   selective antagonist (MPP dihydrochloride). We studied mER&#945; expression during   the estrous cycle and its regulation by gonadal steroids in vivo by flow   cytometry. We identified ER&#945; variants in the plasma membrane of anterior   pituitary cells during the estrous cycle and studied E2 regulation of these mER&#945;   variants in vitro by surface biotinylation and Western Blot. E2-BSA-induced   apoptosis was abrogated by MPP in total anterior pituitary cells and   lactotropes. In cycling rats, we detected a higher number of lactotropes and a   lower number of somatotropes expressing mER&#945; at proestrus than at diestrus.   Acute E2 treatment increased the percentage of mER&#945;-expressing lactotropes   whereas it decreased the percentage of mER&#945;-expressing somatotropes. We detected   three mER&#945; isoforms of 66, 39 and 22 kDa. Expression of mER&#945;66 and mER&#945;39 was   higher at proestrus than at diestrus, and short-term E2 incubation increased   expression of these two mER&#945; variants. Our results indicate that the rapid   apoptotic action exerted by E2 in lactotropes depends on mER&#945;, probably   full-length ER&#945; and\/or a 39 kDa ER&#945; variant. Expression and activation of mER&#945;   variants in lactotropes could be one of the mechanisms through which E2   participates in anterior pituitary cell renewal during the estrous cycle.","palabras_clave":"Estrogens|Pituitary gland"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88760,"idioma_id":4,"titulo":"Size related changes in sagitta otoliths of Australoheros facetus (Pisces, Cichlidae) from South America.","resumen":"ABSTRACT The Australoheros facetus, locally known as ?chanchita?, is the southernmost (38º44&#8242;S) distributed cichlid species in South America where it is eurytopic and abundant in the pampasic ?laguna?, and an important dietary component of numerous piscivorous fishes and birds. The objective of the present study was to extend and correct the description of sagitta otoliths of Australoheros facetus and evaluate the occurrence of morphological and morphometric changes at different development stages. The sagittae were described morphologically and the morphometric analyses performed using the regression equation of allometric growth and discriminant analysis. The results of this analysis indicate that the sagitta of A. facetus acquires its definitive shape at 60 mm maturity, laboratory standard length (LS), which is near the lower limit of the size range achieved in laboratory conditions. The main difference compared to individuals below 60 mm LS can be seen in the general shape, type of dorsal and ventral rims, type of cauda ending, and presence of a groove at the posterior end. The presented results on ontogenetic changes in otolith morphology can be used in studies of trophic ecology to avoid overestimating the number of prey species found in the diet of freshwater piscivorous fishes and birds.     Size related changes in sagitta otoliths of Australoheros facetus (Pisces; Cichlidae) from South America - ResearchGate. Available from: http:\/\/www.researchgate.net\/publication\/263748593_Size_related_changes_in_sagitta_otoliths_of_Australoheros_facetus_%28Pisces_Cichlidae%29_from_South_America [accessed Apr 27, 2015].","palabras_clave":"Australoheros|Cichlidae|sagitta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88761,"idioma_id":4,"titulo":"Highly Ordered, Accessible and Nanocrystalline Mesoporous TiO2 Thin Films on Transparent Conductive Substrates","resumen":"Highly porous (Vmesopore = 25-50%) and ordered mesoporous titania thin films (MTTF) were prepared on ITO(indium tin oxide)-covered glass by a fast two-step method. The effects of substrate surface modification and thermal treatment on pore order, accessibility and crystallinity of the MTTF were systematically studied for MTTF deposited onto bare and titania modified ITO. MTTF exposed briefly to 550 °C resulted in highly ordered films with grid-like structures, enlarged pore size, and increased accessible pore volume when prepared onto the modified ITO substrate. Mesostructure collapse and no significant change in pore volume were observed for MTTF deposited on bare ITO substrates. Highly crystalline anatase was obtained for MTTF prepared on the modified-ITO treated at high temperatures, establishing the relationship between grid-like structures and titania crystallization. Photocatalytic activity was maximized for samples with increased crystallization and high accessible pore volume. In this manner, a simple way of designing materials with optimized characteristics for optoelectronic applications was achieved through the modification of the ITO surface and a controlled thermal treatment.","palabras_clave":"TITANIA|SOL-GEL|OPTOELECTRONIC|PHOTOCATALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88762,"idioma_id":5,"titulo":"Frugivoría y remoción de frutos ornitócoros en fragmentos del bosque chaqueño de Córdoba (Argentina)","resumen":"La pérdida de bosques naturales y su fragmentación en el paisaje por actividad agrícola pueden afectar procesos ecológicos como la  dispersión biótica y también el mantenimiento de la diversidad de especies nativas y la invasión de plantas exóticas. En el contexto de  la fragmentación del bosque chaqueño de la provincia de Córdoba se evaluó remoción y frugivoría de frutos carnosos en especies de  dos fragmentos con superficie menor a 5 ha y dos de bosque continuo superior a 300 ha. Una vez por semana durante dos meses los  frutos de cada individuo se contabilizaron tomándose como indicador de la dispersión biótica a la probabilidad de supervivencia de los  frutos (PSF). Los elementos florísticos ornitócoros incluyen a 15 especies, principalmente leñosas. En todas las especies ornitócoras  presentes en cada sitio se encontraron diferencias en la PSF, siendo mayor en los fragmentos pequeños respecto a los sitios de bosque  continuo. Asimismo, la PSF fue menor en la especie arbustiva de origen exótico en relación con la nativa. Contrariamente, en las  especies exóticas leñosas la PSF fue mayor que en las nativas. Estos resultados sugieren que la dispersión de frutos es afectada por  la reducción del bosque chaqueño y que los fragmentos pequeños son aún utilizados por las aves como áreas de alimentación. Este  comportamiento de las aves sería importante para la persistencia y colonización de nuevos sitios por las plantas con frutos carnosos,  así como para la conservación de los pequeños fragmentos de bosque inmersos en los agroecosistemas del centro de Argentina.","palabras_clave":"Pérdida de bosque|Remoción de frutos|Aves|Comunidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88763,"idioma_id":4,"titulo":"Adsorption of ochratoxin A and zearalenone by potential probiotic Saccharomyces cerevisiae strains and its relation with cell wall thickness","resumen":"Aims: to examine Saccharomyces cerevisae strains, with previously reported beneficial properties and aflatoxin B1 binding capacity, for their ability to reduce ochratoxin A and zearalenone and to study the relation between cell wall thickness and detoxificant ability of yeast strains.  Methods and Results: mycotoxin binding assay at different concentrations and the effect of gastrointestinal conditions on mycotoxin binding were evaluated. Ultrastructural studies of yeast cells were performed by transmission electronic microscopy. All tested strains were capable to reduce ochratoxin A and zearalenone. Saccharomyces cerevisiae RC012 and RC016 showed the highest ochratoxin A reduction percentage, whereas RC009 and RC012 strains showed the highest zearalenone reduction percentages. Cell diameter\/cell wall thickness relation showed a positive correlation between cell wall thickness and mycotoxin reduction ability. After exposure to gastrointestinal conditions, a significant increase in the mycotoxin binding was observed.  Conclusions: all tested Saccharomyces cerevisiae were able to reduce ochratoxin A and zearalenone and a physical adsorption could be the main mechanism involved in mycotoxin reduction. Gastrointestinal conditions would enhance adsorption and not decrease the mycotoxin-adsorbent interactions.             Significance and Impact of Study: live strains with mycotoxin binding ability and beneficial properties are potentially probiotics to be included in animal feed. Previous and the present results suggest that RC008 and RC016 strains are the most promising candidates for functional feed product development.           ","palabras_clave":"Saccharomyces cerevisiae, |ochratoxin A, zearalenone|gastrointestinal conditions|cell wall thickness"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88764,"idioma_id":4,"titulo":"Fungal and mycotoxin contamination in mixed feeds: evaluating risk in cattle intensive rearing operations (feedlots)","resumen":"Argentina is the fourth global beef producer. Exposure to mycotoxins through contaminated feed is a major hazard for ruminants. In the present study we assess mycobiota, aflatoxin B1 (AFB1), fumonisin B1 (FB1), deoxynivalenol (DON) and zearalenone (ZEA) levels in total mixed rations (TMRs) during two consecutive years. Total fungal counts were evaluated and fungal species were identified. Also, ability of A. flavus isolates to produce AFB1 in vitro was tested. Natural contamination with AFB1 and FB1 was quantified by HPLC. Deoxynivalenol and zearalenone were analysed by immunochromatography and thin-layer chromatography (TLC), respectively. Fungal counts varied from not detectable (ND) to 2.10 x 108 CFU g-1. The prevalent genera were Aspergillus spp (60 %) and Fusarium spp (66.7 %), respectively. The prevalent species was Aspergillus fumigatus. 50 % of A. flavus strains produced 75 to 112.5 ¦Ìg g-1 AFB1. 46 % of 2007 samples were contaminated with 4 to 10 ¦Ìg kg-1 AFB1. Deoxynivalenol was detected in 33.3 % of the samples (¡Ý 1. 25 ¦Ìg g-1). Fumonisin B1 and ZEA were not detected. This study can be useful to estimate the mycotoxicological risk of cattle TMRs in this region and to compare results with studies from other beef-producing countries. ","palabras_clave":"Aflatoxins|cattle |deoxynivalenol|feedstuffs|fumonisins"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88765,"idioma_id":4,"titulo":"FUNGI AND MYCOTOXINS FROM PRE AND POST STORAGE BREWER?S GRAIN INTENDED FOR BOVINE INTENSIVE-REARING","resumen":"The aim of the study was to determine the mycobiota and natural levels of mycotoxins such as aflatoxin B1 (AFB1), ochratoxin  A (OTA), fumonisin B1 (FB1), and deoxynivalenol (DON) present in brewers grains pre- and poststored intended for bovine  intensive rearing. Poststored (80%) samples had counts higher than 1 × 104 colony-forming units (CFU\/g). Cladosporium spp.  and Aspergillus spp. were isolated at high frequencies. Aspergillus flavus was the prevalent isolated species. Prestored (70%)  and poststored (100%) samples showed AFB1 levels over the recommended limits (20 &#956;g\/Kg), and OTA levels were below the  recommended limits (50 &#956;g\/Kg) while pre- and poststored samples did not show FB1 and DON natural contamination levels. The  presence of mycotoxins in this substrate indicates the existence of contamination. Regular monitoring of feeds is required in order  to prevent chronic and acute toxic syndromes related to this kind of contamination.","palabras_clave":"FUNGI AND MYCOTOXINS|PRE-AND POSTSTORAGE BREWER´S|BOVINE|INTENSIVE REARING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88766,"idioma_id":4,"titulo":"Gliotoxin contamination in and pre and post fermented corn, sorghum and wet brewers grains silage in Sao Paulo and Rio de Janeiro State, Brazil","resumen":"Aims: The aim of this study was to determine total fungal counts and the relativedensity of Aspergillus fumigatus and related species in silage samplesintended for bovines before and after fermentation as well as to monitor thenatural occurrence of gliotoxin in silage samples (pre- and postfermentation).Methods and methods: The survey was performed in farms located in Sa?oPaulo and Rio de Janeiro States in Brazil. In addition, the ability of A. fumigatusstrains and related species strains to produce gliotoxin was also evaluated.A total of 300 samples were taken, immediately after opening of the silo (3?5months) and during the ensiling period. Fungal counts were done by the surface-spread method. Gliotoxin production ability of isolates and natural contaminationwere determined by HPLC.Results: All postfermented samples had a total number of moulds exceeding 1· 104 CFU g)1, with Aspergillus sp. as the most prevalent genus. Frequency ofstrains, among A. fumigatus and related species, was able to produce gliotoxinwas similar in pre- and postfermented samples, except for sorghum, whichshowed differences between both kinds of samples. The highest toxin levelswere produced by strains isolated from postfermented samples. More than 50%of the samples showed gliotoxin contamination levels that exceeded concentrationsknown to induce immunosuppressive and apoptotic effects in cells.Conclusions: The present data suggest that care should be taken because gliotoxincontamination in feedstuffs could affect productivity and also present ahealth risk for herds.Significance and Impact of the Study: Gliotoxin was found at quite importantconcentrations levels in pre- and postfermented substrates and its presencecould therefore probably affect the productivity and health of herds. Currentconservation and management practices do not avoid contamination with A.fumigatus on silage. Therefore, farm workers should be adequately protectedduring its handling.Journal of Applied Microbiology ISSN 1364-5072ª","palabras_clave":"Gliotoxin|Aspergillus fumigatus|silage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88767,"idioma_id":4,"titulo":"Fungi and aflatoxin B1 in pre and post fermented sorghum trench type silos destined to bovine intensive-rearing in Brazil.","resumen":"The harmful effects of fungi in sorghum silage are an important matter in many countries with hot climates. This culture is very susceptible to fungal contamination and the storage and processing of this substrate are ideal for the development of fungi there are able to produce mycotoxins. The contamination with mycotoxins, secondary products of the metabolism of certain fungi, that promotes risks to both animal and human health, causes numerous losses for the country. The aim of this study was to identify the toxicogenic fungi present in sorghum silage for beef cattle consumption and determine the occurrence of aflatoxin B1 (AFB1). A total of 60 pre fermented and 60 post fermented samples of sorghum silage were analyzed. Total fungal counts and natural incidence of toxigenic Aspergillus, Penicillium y Fusarium species were performed on dichloran rose bengal chloranphenicol agar, dichloran glycerol agar 18% and Nash-Snyder culture media. Aflatoxin B1 contamination was determined using high pressure liquid chromatography (HPLC). About 30% of samples from pre-fermented sorghum and 55% of post-fermented samples were above the recommended limits (1.0 x 104 CFU\/g). The most frequent fungal species in both types of sorghum samples were A. flavus, P. citrinum, P. islandicum and F. verticillioides. An average of 32% samples, pre and post-fermented, were positive for AFB1. The presence of fungi and AFB1 in the feedstuffs indicates contamination. This toxin could affect animal productivity and health. This fact requires periodic monitoring to prevent the occurrence of mycotoxicosis in animal production. ","palabras_clave":"aflatoxin B1|bovine intensive-rearing|fungi|silage"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88768,"idioma_id":4,"titulo":"Combined effects of aflatoxin B1 and corticosterone treatment on selected performance indices and liver histopathology in Japanese quail","resumen":"Animal feed may be  contaminated with different mycotoxins, with aflatoxin B1 (AFB1)  being a very common and toxic compound.  Considering that birds normally have to cope  with different stressful situations at the same time, the present study aims to  evaluate the effects of feed contamination with AFB1, in combination  with corticosterone (CORT) treatment in  drinking water (a model to induce physiological stress in birds) on selected  performance indices (i.e., body weight, feed conversion, egg production, as  well as macroscopic and microscopic liver alterations). At 5 wk of age,  quail were randomly assigned to 1 of 6 dietary treatment groups that resulted from  the combination of the presence or absence of CORT in drinking water (5 mg\/L)  with the presence or absence of AFB1 contamination (0, 100 or 500 &#956;g\/kg).  The animals remained in these treatment from 5 to  11 wks of age. There were 6 replicates  per treatment, each containing two males and two females. Contamination  with 100 &#956;g\/kg of AFB1 induced no  changes in body weight, feed conversion and egg production  parameters. Quail fed  with 500 &#956;g of AFB1\/kg  showed significant decreases in body weight and feed consumption compared to their control  counterparts. CORT in combination with 500&#956;g AFB1\/kg  intensified the negative effects observed on body weight and feed consumption and also had negative effects on feed conversion rate and  egg production parameters, suggesting thatthe adverse effects of contamination with AFB1  are intensified in situations of chronic stress. Quail treated  with 500 µg\/kg of AFB1 showed hepatocytes with degree 1 and 2 lesions, and all  quail treated with 500 µg\/kg of AFB1 in combination with CORT showed liver lesions of degree 2 (i.e. hepatocytes with fatty macro and microvacuoles and necrosis). This result is also consistent with the hypothesis that  chronic stress exacerbates the  effect of the AFB1 contamination. In conclusion, this study suggests that the negative effects of  AFB1 contamination are  increased when overlapped with a chronic stressful stimulation.","palabras_clave":"AFLATOXIN  B1|CORTICOSTERONE|PERFORMANCE|JAPANESE QUAIL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88769,"idioma_id":4,"titulo":"Saccharomyces cerevisiae strains and the reduction of Aspergillus parasiticus growth and aflatoxin B1 production at different interacting environmental conditions, in vitro","resumen":"The effect of Saccharomyces cerevisiae RC008 and RC016, previously selected based on their aflatoxin B1 binding ability and beneficial properties, against Aspergillus parasiticus under different interacting environmental conditions was evaluated. Studies on the lag phase, growth rate and aflatoxin B1 production were carried out in vitro under different regimes of aw (0.95 and 0.99); pH (4 and 6); temperature (25 and 37°C) and oxygen availability (normal and reduced). Both yeast strains showed great antagonistic activity at pH 4, decreasing growth rate compared to the control. The RC008 strain showed the greatest inhibitory activity at all assayed conditions. Aspergillus parasiticus was able to produce large amounts of AFB1 in vitro. A significant decrease of AFB1 levels in comparison with the control were observed with yeast interaction. Differences between control and treatment values ranged between 130 and 5400 ng\/ml. Saccharomyces cerevisiae RC008 and RC016 could be considered as effective agents to reduce growth and AFB1 production at different interacting environmental conditions, related to that found in stored feedstuff. The importance of the present work lays in the search for live strains with both probiotic and bio-control properties, able to prolong the safe storage of feedstuff and exert beneficial properties after animal consumption, to be included in a novel product to animal feed.","palabras_clave":"ASPERGILLUS PARASITICUS|AFLATOXIN B1 PRODUCTION|ENVIRONMENTAL CONDITIONS|SACCHAROMYCES CEREVISIAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88770,"idioma_id":4,"titulo":"First record of a mosquito iridescent virus in Culex pipiens L. (Diptera: Culicidae)","resumen":"The mosquito iridescent viruses (MIVs) are large icosahedral DNA viruses that replicate and assemble in the cytoplasm of the host. Paracrystalline arrangements of virions that accumulate in the cytoplasm produce an iridescent color that is symptomatic of acute infections. In August 2010 we found larvae of Culex pipiens with these symptoms in suburban ditches around the city of La Plata, Argentina. Electron microscope studies, DNA sequencing, and phylogenetic analysis of the major capsid protein confirmed this as the first record of a MIV in C. Pipiens.","palabras_clave":"iridovirus|Culex pipiens"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88771,"idioma_id":4,"titulo":"Population dynamics between the mermithid   Strelkovimermis spiculatus (Nematoda: Mermithidae) and the floodwater   mosquito Ochlerotatus albifasciatus (Diptera: Culicidae) over time.","resumen":"We investigated the population dynamics of Strelkovimermis spiculatus in Ochlerotatus albifasciatus to determine the abiotic and biotic parameters involved in this host-parasite system. Weekly samplings performed from May 2007 through May 2010 in three ponds located in open areas of La Plata, Argentina revealed that parasitism by S. spiculatus in O. albifasciatus occurred throughout all seasons with differences in effectiveness among breeding habitats: A mosquito-larva reduction of 80.7% was observed in a habitat where 100% of the generations were infected by nematodes; an intermediate situation (a 41.9% reduction) involved a lower percentage of parasitism above 50% although nematode infection was likewise registered in 92.9% of the generations. Finally, a mosquito-larva reduction of 2.68% was recorded where only 46.0% of the generations were parasitized and at levels of nematode infection below 50%. We analyzed the effects of abiotic and biotic parameters on S. spiculatus infections. The floodedsurface area was the only variable significantly associated with percent infection. Infection prevalence correlated positively with the mean number of emerged nematodes per larva and with the S. spiculatusmale-to-female ratio in each parasitized-mosquito generation. In conclusion, the frequency over time and levels of infection are key parameters in the regulation of mosquito populations by this mermithid.","palabras_clave":"NEMATODA|MERMITHIDAE|STRELKOVIMERMIS SPICULATUS|CULICIDAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88772,"idioma_id":4,"titulo":"Mammal functional diversity loss under human-induced disturbances in arid lands","resumen":"Human activities are drastically changing the composition of mammal communities and increasing species local extinctions. Although it is well recognized that species influence the way in which ecosystems function through the diversity of resource use traits, little is known regarding the consequences of ecosystem functioning on changing biodiversity. We summarized studies that analyzed the effects of anthropogenic disturbances on mammal assemblages in arid and semi-arid lands of the world. We analyze for the first time changes in functional diversity values under a wide variety of disturbances using a meta-analysis. General mean effect size was significantly negative and marginally heterogeneous. Grouping into ecosystems showed a varied response, mostly negative but not significant. When considering disturbance types as moderator factor functional diversity respond in a negative way to all types, but the strongest effects was seen when the mechanism by which disturbance effects ecosystem was analyzed. ´Herbivory´ effect was the least aggressive, and contrary, ´species change´ strongly and negatively affected functional diversity. When disturbance generates changes in species and resources, and new state properties highly differ from the initial state property, the regime shift seen in vegetation has drastic consequences over mammal functional diversity. This loss of functional diversity may generate positive feedbacks that help to maintain degraded states of the ecosystem.","palabras_clave":"BIODIVERSITY MEASURE|ECOSYSTEM FUNCTIONING|EFFECT TRAITS|LAND USE CHANGE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88773,"idioma_id":4,"titulo":"Galaxy populations in the Antlia cluster - III. Properties of faint early-type galaxies","resumen":"We present a new analysis of the early-type galaxy population in the central region of the Antlia cluster, focusing on the faint systems like dwarf ellipticals (dE) and dwarf spheroidals (dSph). The colour-magnitude relation (CMR) and the relation between luminosity and mean effective surface brightness for galaxies in the central region of Antlia have been previously studied in Paper I of the present series. Now we confirm 22 early-type galaxies as Antlia members, using GEMINI-GMOS and MAGELLAN-MIKE spectra. Among them, 15 are dEs from the FS90 Antlia Group catalogue, 2 belong to the rare type of compact ellipticals (cE), and 5 are new faint dwarfs that had never been catalogued before. In addition, we present 16 newly identified low surface brightness galaxy candidates, almost half of them displaying morphologies consistent with being Antlia´s counterparts of Local Group dSphs, that extend the faint luminosity limit of our study down to MB = -10.1 (BT = 22.6) mag. With these new data, we built an improved CMR in the Washington photometric system, i.e. integrated T1 magnitudes versus (C-T1) colours, which extends ~4 mag faintwards the limit of spectroscopically confirmed Antlia members. When only confirmed early-type members are considered, this relation extends over 10 mag in luminosity with no apparent change in slope or increase in colour dispersion towards its faint end. The intrinsic colour scatter of the relation is compared with those reported for other clusters of galaxies; we argue that it is likely thatthe large scatter of the CMR, usually reported at faint magnitudes, is mostly due to photometric errors along with an improper membership\/morphological classification. The distinct behaviour of the luminosity versus mean effective surface brightness relation at the bright and faint ends is analyzed, while it is confirmed that dE galaxies on the same relation present a very similar effective radius, regardless of their colour. The projected spatial distribution of the member sample confirms the existence of two groups in Antlia, each one dominated by a giant elliptical galaxy and with one cE located close to each giant. Size and position, with respect to massive galaxies, of the dSph candidates are estimated and compared to Local Group counterparts.","palabras_clave":"RADIAL|VELOCITIES|GALAXIES|CLUSTER|ANTLIA|DWARF|ELLIPTICAL|LENTICULAR|PHOTOMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88774,"idioma_id":4,"titulo":"Structure and dynamics of nano-sized raft-like domains on the plasma membrane","resumen":"Cell membranes are constitutively composed of thousands of different lipidic species, whose specific organization leads to functional heterogeneities. In particular, sphingolipids, cholesterol and some proteins associate among them to form stable nanoscale domains involved in recognition, signaling, membrane trafficking, etc. Atomic-detail information in the nanometer\/second scale is still elusive to experimental techniques. In this context, molecular simulations on membrane systems have provided useful insights contributing to bridge this gap. Here we present the results of a series of simulations of biomembranes representing non-raft and raft-like nano-sized domains in order to analyze the particular structural and dynamical properties of these domains. Our results indicate that the smallest (5 nm) raft domains are able to preserve their distinctive structural and dynamical features, such as an increased thickness, higher ordering, lower lateral diffusion, and specific lipid-ion interactions. The insertion of a transmembrane protein helix into non-raft, extended raft-like, and raft-like nanodomain environments result in markedly different protein orientations, highlighting the interplay between the lipid-lipid and lipid-protein interactions.","palabras_clave":"Raft|Molecular Dynamics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88775,"idioma_id":4,"titulo":"Molecular Dynamics Study of the Interaction of Arginine with Phosphatidylcholine and Phosphatidylethanolamine Bilayers","resumen":"In this work, the differential interaction of zwitterionic arginines with fully hydrated dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) bilayers was analyzed by molecular dynamics simulations. In both systems, arginine binds to lipids with the carboxylate moiety oriented toward the aqueous phase, in agreement with previous experimental determinations of æ potential of DMPC and DMPE liposomes. The guanidinium groups are found at different depths within the bilayers indicating that some arginines are buried, especially in DMPE. We observe, in the DMPE system, that the strongest interaction occurs between the guanidinium group and the carbonyl oxygen of the lipid. In the case of DMPC membranes, the strongest interaction is found between the guanidinium groups of the arginines and the phosphate groups of the lipids. Unexpectedly, arginine zwitterions are stabilized through the creation of hydrogen bonds (HB), either with water or with polar groups of the lipids. The mechanisms of interaction seem to be different in both membranes. In DMPE bilayers, arginines insert by breaking the inner HB network of the polar head groups, consequently increasing the occupied area per lipid molecule. In the DMPC bilayers the arginines insert by replacing the already present water molecules within the membrane, without significant effects on the area per lipid.","palabras_clave":"LIPID MEMBRANES|DMPC DMPE|ARGININE|MOLECULAR DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88776,"idioma_id":4,"titulo":"Similar structures but different mechanisms. Prediction of FABPs-Membrane interaction by electrostatic calculation","resumen":"The role of fatty acid binding proteins as intracellular fatty acid transporters may require their direct interaction with membranes. In this way different mechanisms have been previously characterized through experimental studies suggesting different models for FABPs\u2013membrane association, although the process in which  the molecule adsorbs to the membrane remains to be elucidated. To estimate the importance of the electrostatic energy in the FABP\u2013membrane interaction, we computationally modeled the interaction of different  FABPs with both anionic and neutral membranes. Free Electrostatic Energy of Binding (dE), was computed using Finite Difference Poisson Boltzmann Equation (FDPB) method as implemented in APBS (Adaptive Poisson  Boltzmann Solver). Based on the computational analysis, it is found that recruitment to membranes is facilitated by non-specific electrostatic interactions. Also energetic analysis can quantitatively differentiate  among the mechanisms of membrane association proposed and determinate the most energetically favorable configuration for the membrane-associated states of different FABPs. This type of calculations could provide a  starting point for further computational or experimental analysis.","palabras_clave":"FABP|ELECTROSTATIC INTERACTION|PROTEIN-MEMBRANE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88777,"idioma_id":4,"titulo":"Rapid Identification of Histoplasma capsulatum Directly from Cultures by Multiplex PCR","resumen":"Mycopathologia. 2012 Dec;174(5-6):451-6. doi: 10.1007\/s11046-012-9567-2. Epub 2012 Jul 21.Rapid identification of Histoplasma capsulatum directly from cultures by multiplex PCR.Elías NA, Cuestas ML, Sandoval M, Poblete G, Lopez-Daneri G, Jewtuchowicz V, Iovannitti C, Mujica MT.SourceDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 piso 11, 1121 Buenos Aires, Argentina.AbstractThe multiplex PCR developed from a suspension of the yeast fungi correctly identified fifty-one clinical of H. capsulatum var. capsulatum strains isolated from clinical samples and soil specimens. The multiplex PCR was developed by combining two pairs of primers, one of them was specific to the H. capsulatum and the other one, universal for fungi, turned out to be specific to H. capsulatum, regardless of the fungus isolate studied. Primers designed to amplify a region of about 390-bp (Hc I-Hc II) and a region of approximately 600-bp (ITS1-ITS4) were used to identify a yeast isolated as H. capsulatum when both regions could be amplified. Absolute agreement (100 % sensitivity) could be shown between this assay and the cultures of H. capsulatum according to their morphological characteristics. Failure to amplify the target DNA sequence by PCR with primers Hc I-Hc II in the presence of the ITS1-ITS4 amplicon in isolates of P. brasiliensis, Cryptococcus neoformans, Trichosporon spp, Candida glabrata, C. albicans, C. tropicalis, C. parapsilosis, C. krusei, or Penicillium marneffei was an unequivocal sign of the high specificity of this assay. The assay specificity was also found to be 100 %. Incipient yeast forms obtained from clinical samples were identified as H. capsulatum by the PCR assay described before the morphological characteristics were registered shortening the time of diagnosis.","palabras_clave":"FUNGAL IDENTIFICATION|HISTOPLASMOSIS|HC100PCR|INTERGENIC SPACER REGION|MOLECULAR DIAGNOSIS|MULTIPLEX PCR|UNIVERSAL FUNGAL PRIMERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88778,"idioma_id":4,"titulo":"Interspecific kleptoparasitism by Brown-headed Gulls (Chroicocephalus maculipennis) on two hosts with different foraging strategies: a comparative approach","resumen":"Kleptoparasitism is a well known foraging strategy used opportunistically by many seabirds. Our study compares the strategies performed by a facultative kleptoparasite species, the Brown-hooded Gull (Chroicocephalus  maculipennis), associated with two hosts with different foraging strategies, the American Oystercatcher (Haematopus palliatus) and Red-gartered Coot (Fulica armillata). In total,97%of the prey items stolen from Oystercatchers were the clam Tagelus plebeius, and all prey items stolen from Coots were the crab Cyrtograpsus angulatus. The attack rate by Gulls (number of kleptoparasitic attacks per unit time) did not differ significantly between Oystercatchers and Coots, but the success rate of attacks (successful kleptoparasitic attacks as a proportion of total attacks) was greater for attacks on Coots than on Oystercatchers. The mean rate of feeding (number of stolen items ingested per minute) by Brown-hooded Gulls did not differ with host. Gulls strongly selected large prey when stealing food. The comparison of net intake (cost\u2013benefit balance)  for each kleptoparasite\u2013host system showed that profitability was 3.5 times higher when kelptoparsitising Coots than when stealing from Oystercatchers. We suggest future work should study in more detail the costs and benefits for kleptoparasites with multiple hosts in similar systems elsewhere.","palabras_clave":"facultative kleptoparasite|foraging strategy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88779,"idioma_id":4,"titulo":"Characterization of probiotic properties of lactic acid bacteria isolated from an estuarine environ-ment for application in rainbow trout (Oncorhynchus mykiss, Walbaum) farming","resumen":"Abstract Bacterial attachment to fish surfaces andthe capacity to compete with pathogens for adhesionsites are essential characteristics in order to select acandidate probiotic for aquaculture. Twelve lactic acidbacteria (LAB) isolated from fish and sediments fromBahý´a Blanca Estuary, Argentina, were examined forin vitro adhesion to rainbow trout mucus, cell surfaceproperties and competitive exclusion against twosalmonid pathogens, Yersinia ruckeri and Aeromonassalmonicida. In order to assess their survival throughthe digestive tract, pH and rainbow trout bile tolerancewere evaluated. All LAB strains survived for 1.5 hincubation in 10% rainbow trout bile. Most of thestrains survived 1.5 h at pH 3.0 and three of themshowed a reduction of viable counts lower than 2logarithms, with respect to control (pH 6.5). Only afew strains showed tolerate pH 2.0. All the strainswere able to attach to rainbow trout skin mucus (104?106 cells\/cm2), to glass (104?105 cells\/cm2) and tostainless steel (103?104 cells\/cm2). Sixty percent ofLAB strains were capable of competing with andsuccessfully excluding Y. ruckeri and all strains wereable to displace it. Against A. salmonicida, 75% ofLAB strains competed successfully, 50% were capableof displacing and 60% excluded this pathogen. Ourdata suggest the potential of these strains as antiinfectiveagents for use in rainbow trout culture. Thisstudy is the first report on the probiotic potential ofLAB strains isolated from an estuarine environmentfrom Argentina.","palabras_clave":"Lactic acid bacteria|Probiotic|Rainbow trout"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88780,"idioma_id":5,"titulo":"BEHAVIOR OF THE DIGITAL FOURIER TRANSFORM AS NUMERICAL FILTER IN DISTANCE PROTECTION OF SERIES COMPENSATED TRANSMISSION LINES. SIMULATIONS WITH A REAL TRANSMISSION SYSTEM","resumen":"In this paper, a MATLAB model of a Digital Fourier Transform (DFT)-based digital distance relay was developed and then its behavior was analyzed when it is applied on distance protection of a real series compensated transmission system, belonging to the Chilean generation and transmission utility Colbún S.A. The complete signal processing and the impedance calculation of real relays are simulated by the model. The transmission system was modeled with ATP and various fault types at buses and diverse line locations were simulated. The DFT-model response was evaluated in each fault case from the obtained current and voltage signals. The results show how series capacitors impact negatively on the impedance calculation using DFT.","palabras_clave":"Digital Fourier Transform|Transmission Line Protection|Series Capacitor|Relay Model|Signal Processing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88781,"idioma_id":4,"titulo":"Two-Channel Multirate Network Equivalent Aimed To Real Time Electromagnetic Transient Calculation","resumen":"This paper proposes a computationally efficient multirate scheme to model a linear and time invariant part of an electric network for electromagnetic transient calculation. The main contribution is expected in the field of real-time calculation, where very efficient models are required to fulfill stringent time performance requirements. Two models of the equivalent sub-network based on different time steps are implemented in the low and high frequency channels of a basic Laplacian Pyramid unit. A detailed model based on the longest time step reproduces the low frequency response, while a simplified (lower order) model, based on the shortest time step, reproduces the high frequency behavior. In this way, an accurate response of the equivalent over a wider frequency range can be achieved as compared to previous proposals based on a single low frequency channel. Also, the proposed scheme make a much greater flexibility in choosing the decimation factor possible as compared to a previous proposal of two co-authors based on a two fold decimated filter banks.","palabras_clave":"Transients|Networks|Multirate Signal Processing|Transmission Line Modelling|Transient Response|Transmission Network"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88782,"idioma_id":4,"titulo":"HIGH-SPEED NON-UNIT TRANSMISSION LINE PROTECTION USING SINGLE-PHASE MEASUREMENTS AND AN ADAPTIVE WAVELET: ZONE  DETECTION AND FAULT CLASSIFICATION","resumen":"This work describes a transmission line protection scheme with two protection functions: directional-zone and fault classification. The proposed scheme requires no information from remote ends and uses current measurements of only one phase of the three-phase systems for determining the fault direction, the faulted line and the fault type. Information concerning the high frequency components of transient current signals is extracted with discrete wavelet transform (DWT) by using an adaptive wavelet, which has been specifically designed for relaying purposes, as analysis filter. After that, Bayesian linear discriminant analysis is employed for data classification. The present work highlights that the adaptive wavelet used here presents advantages for transmission line protection rather than predefined mother wavelets. Results demonstrate that the proposed scheme effectively distinguishes the faulted zone,  the fault direction and the fault type. Therefore, it offers primary protection to total line length, remote backup protection for the next transmission line, and also the possibility to implement single-pole tripping. Current signals of roughly two milliseconds are analyzed then the proposed methodology can be implemented in high-speed protection schemes for extra- and ultra-high voltage (EHV\/UHV) networks.","palabras_clave":"ADAPTIVE FILTERS|BAYES METHODS|POWER TRANSMISSION LINES|POWER SYSTEM PROTECTION|SIGNAL PROCESSING|WAVELET TRANSFORMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88783,"idioma_id":4,"titulo":"Vaccination of pregnant cows with EspA, EspB, &#947;-intimin, and Shiga toxin 2 proteins from Escherichia coli O157:H7 induces high levels of specific colostral antibodies that are transferred to newborn calves","resumen":"Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major cause of intestinal disease and hemolytic uremic syndrome, a serious systemic complication that particularly affects children. Cattle are primary reservoirs for EHEC O157:H7 and the main source of infection for humans. Vaccination of cattle with different combinations of bacterial virulence factors has shown efficacy in decreasing EHEC O157:H7 shedding. It is, therefore, important to demonstrate whether vaccination of pregnant cows with EHEC O157:H7 induces high titersof transferable antibodies to avoid early colonization of calves by the bacteria. In this study we evaluated the ability of EspA, EspB, the C-terminal fragment of 280 amino acids of &#947;-intimin (&#947;-intimin C280) and inactivated Shiga toxin (Stx)2 proteins to induce specificantibodies in colostrum and their passive transference to colostrum-fed calves. Friesian pregnant cows immunized by the intramuscular route mounted significantly high serum and colostrum IgG responses against EspB and &#947;-intimin C280 that were efficiently transferred to their calves. Antibodies to EspB and &#947;-intimin C280 were detected in milk samples of vaccinated cows at d 40 postparturition. Significant Stx2-neutralizing titers were also observed in colostrum from Stx2-vaccinated cows and sera from colostrum-fed calves. The results presented showed that bovine colostrum with increased levels of antibodies against EHEC O157:H7 may be obtained by systemic immunization of pregnant cows, andthat these specific antibodies are efficiently transferred to newborn calves by feeding colostrum. Hyperimmune colostrum and milk may be an alternative to protect calves from early colonization by EHEC O157:H7 and a possible key source of antibodies to block colonization and toxic activity of this bacterium.","palabras_clave":"vaccination|preganan cows|E. coli O157:H7|colostrum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88784,"idioma_id":4,"titulo":"Global trends of rapeseed grain yield stability and rapeseed-to-wheat yield ratio in the last four decades","resumen":"Increases in crop yields are important to ensure food supply for humanity. Global yield trends have beenanalyzed considering public national average data, mainly for cereals but not for rapeseed. As rapeseedand wheat compete for land in crop rotation, it is also important to know how the rapeseed-to-wheat yieldratio is modified in different environments so as to make rapeseed an attractive alternative for farmersaround the world. The present study analyzed historical records of rapeseed from FAO determining yieldstability trends over the last 40 yr, as well as rapeseed competitiveness compared to wheat. Twelvecountries representing a wide range of environments and farming systems were taken into account.Regressions were fitted to the rapeseed yield\/time relationships and residuals of these regressions wereused to evaluate trends in yield stability. Results showed a global rapeseed yield gain of 27 kg ha&#8722;1 yr&#8722;1along the past 40 yr, although fluctuating among decades. In relative terms to 1970, world rapeseedyield increased 3.4% yr&#8722;1. Yield gain in different countries varied from 15 to 40 kg ha&#8722;1 yr&#8722;1, exhibitinglinear, bi- or tri-linear yield trends. Opposite yield trends were observed for Chile and the UK, withsustained yield gain for the former and leveling off for the latter since the mid 1980s. This does not seemto be related to the supply of environmental resources (both countries yielding >3000 kg ha&#8722;1). A highvariability was detected in national yields (0\u2013750 kg ha&#8722;1 or 0\u201360% of yield) and yield stability did notincrease over the last 40 yr in any country. Rapeseed and wheat yields, expressed in relative terms totheir values for 1970, increased in a similar proportion over the last four decades. Global rapeseed-towheatratio ranged 40\u201360% over the last 40 yr, but rapeseed yields can increase up to 80\u2013100% withrespect to wheat in poor environments for wheat (4000 kg ha&#8722;1). It was concluded that rapeseed yields have increased steadily inthe last 40 yr in most studied countries, the yield gain was not accompanied by greater yield stability,and rapeseed competitiveness compared to wheat is at least 40\u201350% in environments with good supplyof resources","palabras_clave":"rapeseed|yiedl"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88785,"idioma_id":5,"titulo":"Procesos de vertiente en el sector noroeste de la cuenca alta del río Sauce Grande, Argentina.","resumen":"La cuenca alta del río Sauce Grande nace en el sur del Sistema de Ventania. Este es un cordón orográfico en forma de arco de rumbo Noroeste-Sureste considerado por Von Gosen et al. (1991) como una faja plegada y corrida con importantes fallas inversas paralelas al rumbo de las sierras. Las sierras que se elevan entre 400 y 700 m de la llanura circundante están compuestas por cordones sub-paralelos cuya diferencia altitudinal es marcada y debida al levantamiento diferencial de los distintos bloques. El área de estudio se localiza en la vertiente suroriental del cordón de Sierra de la Ventana y es la zona de captación de aguas más importante de la cuenca analizada. El objetivo de este trabajo es analizar la morfometría de las pendientes y los procesos de vertientes asociados en el sector noroeste del la cuenca alta del río Sauce Grande. En la zona se desarrollan principalmente actividades recreativas-proteccionistas y urbanas que co-existen con actividades agrícola-ganaderas. El sector se encuentra afectado por crecidas y procesos de remoción en masa generados por lluvias torrenciales. Los estudios sobre morfometría del relieve y cartografía temática vinculados a los procesos de vertiente son incipientes en el suroeste de la provincia de Buenos Aires. Para analizar las vertientes, su trazado y desarrollo y correlacionarlas posteriormente con los procesos que las afectan es necesario conocer aspectos morfométricos, fisiográficos y dinámicos. Para ello se siguió la propuesta metodológica de Pedraza Gilzanz (1996). Se realizaron perfiles topográficos donde se definen las variaciones en la pendiente y los segmentos que la componen. La identificación y análisis de los procesos se basó en la orientación de las laderas y en el grado de inclinación de la pendiente general y de los segmentos en particular. Se elaboró cartografía geomorfológica, de pendientes y se determinaron los tipos y grados de las vertientes y los procesos que se generan en función de los perfiles topográficos. El reconocimiento de campo fue fundamental para la identificación y comprobación de los procesos que actúan en las mismas. ","palabras_clave":"PROCESOS DE VERTIENTE|MORFOMETRIA|SISTEMA DE VENTANIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88786,"idioma_id":5,"titulo":"Geomorfología y procesos de vertiente. Cuenca alta del río Sauce Grande (Buenos Aires, Argentina)","resumen":"El área de estudio se localiza en el suroeste de la provincia de Buenos Aires, Argentina. Allí, se producen procesos de vertientes y crecidas intensas de los arroyos provocadas por lluvias torrenciales de baja frecuencia. La ordenación del territorio es incipiente y la documentación de base para la toma de decisiones es escasa. Por ello, el objetivo de este trabajo es determinar las características geomorfológicas y analizar los procesos de vertiente que se generan en la cuenca alta del río Sauce Grande. La cartografía geomorfológica se elaboró siguiendo la metodología propuesta por Peña Monné (1997). Se analizaron 17 perfiles topográficos según aspectos morfométricos, fisiográficos y dinámicos según la propuesta metodológica de Pedraza Gilsanz (1996). Los primeros resultados evidenciaron que donde aflora el macizo antiguo se generan deslizamientos, flujo de detritos y caídas de roca y sobre las formas climáticas, reptación, arroyada en manto e incisión fluvial. ","palabras_clave":"GEOMORFOLOGIA|PROCESOS DE VERTIENTE|SAUCE GRANDE, ARGENTINA|PERFILES TOPOGRAFICOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88787,"idioma_id":4,"titulo":"The role of orbiting resonances in the vibrational relaxation of I2(B,v0 = 21) by collisions with He at very low energies: a theoretical and experimental study","resumen":"  The low-energy collisions of I2(B,v0 = 21) with He involving collision-induced vibrational   relaxation of I2 are investigated both experimentally and by means of wave packet simulations.   The theoretical cross sections exhibit a structure of peaks originated by orbiting resonances of the  I2(B,v0 = 21) He van der Waals complex formed in the I2 + He collisions. Such a structure   has similar characteristics as the structure of peaks found in the experimental cross sections. In  fact, four of the five peaks of the measured cross sections appear at positions nearly coincident  with those of four of the peaks found in the theoretical cross sections. Thus this result confirms  the experimental finding that enhancement of I2 vibrational relaxation is caused by the population   of I2(B,v0 = 21) He orbiting resonances populated upon the low-energy collisions. The possibility   of using this mechanism in the vibrational cooling of diatomic molecules is discussed","palabras_clave":"dinamica|energía|resonancias|iodo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88788,"idioma_id":4,"titulo":"'H-bonded network rearrangement in the S0, S1 and D0 states of neutral and cationic p-Cresol(H2O)(NH3) complex","resumen":"The H-bonded network rearrangements in the S0, S1 and D0 states of the neutral and cationic p-CreOH(H2O)(NH3) complex were studied experimentally by means of (1+1)\/(1+1?) REMPI (Resonantly Enhanced MultiPhoton Ionization) and time resolved LIF (Laser Induced Fluorescence) spectroscopies combined with DFT (Density Functional Theory) calculations at the B3LYP\/6-311G++(d,p) level. A comparison of the rearrangement process of the Hbonded network in the three states is given. Two cyclic H-bonded isomers were found on the S0 potential energy surface and the results indicate that the rearrangement in this state is unlikely at the temperature of the supersonic expansion due to the presence of a high-energy barrier (7503 cm-1). On the other hand, the re-determination of the S1 excited state lifetimes confirms that neither the H-bonded rearrangement nor the excited state hydrogen transfer (ESHT) reaction take place in the S1 state at the excitation energies of this work. Thus, it is concluded that the absorption of the second photon to reach the D0 state takes place from the S1 state of the cyclic-(OH-OH2-NH3) isomer. A preferential evaporation of H2O upon vertical ionization of the cyclic-(OH-OH2-NH3) isomer is observed which is consistent with a statistical redistribution of the internal energy. Nevertheless, our theoretical calculations suggest that initial excitation of the H-bonded network rearrangement modes may also play a role to leave the H2O molecule as a terminal moiety in a chain-(OH-NH3-OH2)+ isomer. The reaction pathway for the solvent rearrangement involves a double proton transfer process with a very low energy barrier (575 cm-1) that is overcome at the vertical ionization energy of the complex.","palabras_clave":"H-BONDED|CRESOL|CLUSTERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88789,"idioma_id":4,"titulo":"Development of a low cost pulsed laser deposition system for thin films growth","resumen":"Pulsed Laser Deposition (PLD) is a powerful technique to grow thin films. Oxides, Magnetics and superconducting materials have been obtained by PLD and theirs properties are strongly dependent of deposition parameters. The con-struction of a simple and cheap PLD system that is suitable for growing various thin films, including magnetic materi-als, controlling some deposition parameters is presented. The design characteristics and construction are presented for each one of the devices that compose this PLD system. The equipment has the possibility of carrying out films deposi-tion using up to five targets under controlled atmosphere and substrate temperature. The system also allows controlling the cool off sample time after growing up films at high temperatures. A wide range of relative speeds between target and substrate axial rotation can be externally controlled.  With the configuration and the dimensions adopted in their construction, a PLD system of great experimental flexibility is achieved, at a very low cost regarding the commercial systems.  To evaluate their performance and effectiveness, the deposition characteristics of a BaFe12O19 film on (0001) sapphire substrate is presented.","palabras_clave":"Pulsed Laser Deposition|Thin Film|Multilater"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88790,"idioma_id":4,"titulo":"Replacement of calcium for strontium in hamster sperm incubation media: effect on sperm function","resumen":"Calcium (Ca(2+)) is an absolute requirement for a decisive sperm function event: the acrosome reaction (AR). Physiologically, sperm capacitation is a prerequisite for this specialized exocytosis and both events are intimately related. In an effort to separate capacitation from AR, we have been using a modified sperm incubation medium where Ca(2+) is replaced by Strontium (Sr(2+)). The aim of this report is to analyze with more detail the difference between sperm incubated with Ca(2+) or Sr(2+) in several events. We found that sperm undergo the capacitation-related changes in the chlortetracycline (CTC) pattern and tyrosine phosphorylation, and also bind to the zona pellucida (ZP) when using Sr(2+)-instead of Ca(2+)-containing media. However, the spontaneous AR typical of hamster sperm does not take place in Sr(2+)-medium, even if sperm are previously capacitated with Ca(2+). Nevertheless, Sr(2+) was able to sustain AR when cells were treated with thapsigargin or depolarized with K(+) in Na(+)-depleted medium. Considering that the absence of Na(+) increased spontaneous AR in Sr(2+)-medium, we tested whether Na(+)-transport systems could be involved in the inability of Sr(2+)-incubated sperm to undergo AR. We found that when sperm incubated in Sr(2+)-medium are treated with amiloride to inhibit epithelial Na(+) channel (ENaC), they are able to undergo spontaneous AR. The same result was obtained when analyzing AR on the ZP. On the contrary, addition of ouabain (a Na(+)\/K(+)-ATPase inhibitor) or DIDS (a Na(+)\/HCO3(-) co-transporter inhibitor) showed no effect. These results suggest that, differing from what happens in Ca(2+)-incubated sperm, cells incubated in Sr(2+)-modified medium would have an active ENaC.","palabras_clave":"PROTEIN-TYROSINE PHOSPHORYLATION|INDUCED ACROSOME REACTION| MOUSE SPERM|ZONA-PELLUCIDA|MAMMALIAN SPERM|INTRACELLULAR CA2+|CA2+-INDUCED CA2+|EGG ZP3|CAPACITATION|SPERMATOZOA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88791,"idioma_id":4,"titulo":"New insights about the electro-oxidation of glycerol on platinum nanoparticles supported on multi-walled carbon nanotubes","resumen":"Here we investigate the glycerol electro-oxidation reaction on carbon platinum nanoparticles supported  on multi-walled carbon nanotubes (MWCNTs) obtained by reduction with ethylene glycol. The particles  obtained show uniform particle diameters with a little size dispersion (2.8 ± 0.2 nm). Cyclic voltammetry  shows the existence of multiple oxidation peaks, which are related with different electrooxidation  steps. We follow the voltammetric response of Pt\/MWCNT in the presence of glycerol by using in situ  FTIRS. Results suggest that CO2 is produced by two independent pathways. The first one happens at low  potentials and depends on the previous formation of adsorbed CO, while the second one occurs at high  potentials and seems to depend on the reaction of glycerol in solution with adsorbed Pt\u2013O. FTIRS results  also show products of higher degree of oxidation as the potential increases. Results were interpreted in  terms of a growing superficial recovering by Pt\u2013O species with the potential.","palabras_clave":"GLYCEROL ELECTRO-OXIDATION|FTIRS|FUEL CELLS|PLATINUM MWCNT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88792,"idioma_id":4,"titulo":"Carbon xerogels as electrochemical supercapacitors. Relation between impedance physicochemical parameters and electrochemical behaviour","resumen":"The electrochemical behavior of carbon xerogels was studied with the aim of analyzing the  performance of the materials used as electrochemical supercapacitors (SC) and to relate  with physicochemical parameters. These materials have areas involving 1500e2000 m2\/g  measured with the BET equation and a range of pore size distributions.  Conventional electrochemical techniques were used as cyclic voltammetry (CV), which  allowed electrochemical characterization of different materials, and chronopotentiometry  (CD), in order to determine the charge storage capacity of the xerogel at different currents  or discharge rates.  Experimental results using electrochemical impedance spectroscopy (EIS) were interpreted  with a physicochemical model that permitted identifying different parameters of  the electrode, which explain the differences in the behavior of materials.","palabras_clave":"Electrochemical supercapacitors|Porous Electrodes|Electrochemical impedance spectroscopy|Interfacial Area"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88793,"idioma_id":4,"titulo":"The Voigt profile as a sum of a Gaussian and a Lorentzian Functions, when the Weight coefficient depends only on the widths ratio","resumen":"Assuming that V (x)  (1 &#1048576; ) G1(x) + L1(x) is a very good approximation of the Voigt function, in thiswork we analytically nd  from mathematical properties of V (x). G1(x) and L1(x) represent a Gaussian and a Lorentzian function, respectively, with the same height and HWHM as V (x), the Voigt function, x being the distance from the function center.  is obtained as a function of a, a being the ratio of the Lorentz width to the  Gaussian width. We nd that, the Voigt function calculated with the expression we have obtained for , deviates from the exact value less than 0.5% with respect to the peak value.","palabras_clave":"Voigt Profile"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88794,"idioma_id":4,"titulo":"Factors affecting Anastrepha fraterculus female receptivity modulation by accessory gland products","resumen":"In the context of the sterile insect technique (SIT), mass-rearing and male irradiation are imperative. Post-teneral treatments such as the addition of protein in adult´s male diet and male hormonal treatment are used to improve sexual performance and to accelerate sexual maturation. In this work we investigated the effect of male accessory glands products (AGPs) on female receptivity of the South American fruit fly Anastrepha fraterculus (Wiedemann), and the effect of strain rearing history, male irradiation, male diet and hormonal treatment on AGPs. Injections of aqueous extracts of male accessory glands into the abdomen of females reduced their receptivity. The AGPs from laboratory males were more effective in inhibiting female receptivity, compared to AGPs from wild males, irrespective of females´ origin. The AGPs from fertile males were more effective than AGPs from sterile males. The AGPs from protein-fed males were more effective than AGPs from sugar-fed males. Finally, the AGPs of males treated with juvenile hormone were less effective in inhibiting female receptivity than AGPs of untreated males. We conclude that inhibition of sexual receptivity of A. fraterculus mated females is mediated by products in male accessory gland´s and the way that these products act vary widely according to the effect of extrinsic factors. We discuss the results in the perspective of the SIT application for A. fraterculus.","palabras_clave":"ACCESORY GLANDS PRODUCTS|SIT|ANASTREPHA FRATERCULUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88795,"idioma_id":4,"titulo":"Late Triassic bivalves and brachiopods from southern Mendoza, Argentina","resumen":"The Atuel river section in southern Mendoza Province, Argentina, is one of the few South American localities where the Triassic\/Jurassic transition occurs in fully marine deposits. Bivalves and brachiopods from the poorly diverse Late Triassic macrofauna are described, most of them found below the level with Choristoceras cf. marshi Hauer. The fauna contains 15 bivalve species and at least 5 brachiopd species recorded from several Norian?\/Rhaetian fossiliferous levels at Arroyo Malo. The fauna also includes cephalopods, gastropods, a cnidarian, and some foraminifers and ostracods. Bivalves are the most diverse group, with species belonging to 13 superfamilies. Two of the bivalve species are described as new: Pseudolimea riccardii Damborenea n. sp. and Asoella campbellorum Damborenea n. sp. Only one bivalve species ranges into Early Jurassic deposits. The bivalve fauna contains mostly suspension feeder species, including deep infaunal (Pholadomya), shallow infaunal (Minetrigonia?, Nicaniella?, Palaeocardita and Septocardia) and epifaunal species (Cassianella, Liostrea, Praechlamys?, Pseudolimea and Otapiria). Following next in terms of diversity, brachiopods are represented by no less than three orders, and four superfamilies, one of those species being new: Bolilaspirifer riccardii Manceñido n. sp. These species are also epifaunal suspension-feeders, and from a biostratigarphical viewpoint are regarded as members of a newly proposed Assemblage Zone that supports the age correlation with similar faunas from other south Pacific areas.","palabras_clave":"Bivalvia|Brachiopoda|Late Triassic|Biostratigraphy|Mendoza|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88796,"idioma_id":4,"titulo":"Acrosome reaction in the epididymal sperm of chinchilla lanigera. Effect of progesterone, A23187 and stimulation of a GABAA-like receptor","resumen":"Little is known about the reproductive biology of Chinchilla lanigera in captivity. Currently thereare no parameters to evaluate the quality of the semen of males that are sold as breeding stock,so they are selected according to their phenotypic characteristics, which cannot guarantee theirreproductive efficiency. We worked with sexually mature males; the sperm were collected fromthe cauda epididymis by puncture. Capacitated sperm were incubated at 37 &#9702;C with differentconcentrations of progesterone. The results showed a biphasic behavior, where the increasein the percentage of the acrosome reaction (AR) was significant between 2.5\u20135 ìM, and amaximum response with a dose of 20 ìM. Also the suspension of sperm incubated with differentconcentrations of ionophore A23187 inducing response is obtainedwith a concentration of 10ìM.Stimulation of the Gamma-aminobutyric acid (GABA)A-like receptor by treating the sperm withdifferent concentrations of muscimol, a specific receptor agonist, also induce acrosome reaction.The dose-response curve showed a biphasic effect with a maximum response at a concentrationof 2.5 ìM. The pretreatment of sperm suspension with a specific receptor antagonist, picrotoxin,a decrease was observed in the percentage of reacted perm. These studies represent a first steptowards the establishment of standard parameters to determine the functionality and fertilizingcapacity of Chinchilla sperm. In addition, our results indicate that the Chinchilla spermatozoacan undergo the AR when treated with A23187 or progesterone at high percentages. It alsoshows a clear involvement of GABAA-like receptors in acrosome exocytosis in sperm obtained byepididymal cauda.","palabras_clave":"Acrosome Reaction|Epididymal Sperm|Chinchilla lanigera"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88797,"idioma_id":4,"titulo":"Dehydroleucodine and dehydroparishin-B from Artemisia douglasiana inhibit proliferation and motility of B16 melanoma cells","resumen":"Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.","palabras_clave":"Dehydroleucodine|dehydroparishin-B|B16 melanoma cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88798,"idioma_id":5,"titulo":"Estrés oxidativo en cefalópodos: I determinación de TBARs","resumen":"              El estrés oxidativo se produce cuando se genera un desbalance  desfavorable entre las especies reactivas del oxígeno y las defensas  antioxidantes, provocando daño oxidativo a macromoléculas. Varios estudios han  resaltado la importancia del estrés oxidativo en el campo de la ecotoxicología,  particularmente su relación con el impacto que generan los contaminantes que  alcanzan los cuerpos de agua. Cuantificar esos efectos ha permitido su uso como  herramienta de diagnóstico (biomarcadores), con capacidad predictiva del  impacto de los contaminantes sobre los organismos. Uno de&nbsp; los índices más frecuentemente utilizados  para&nbsp; estimar el daño oxidativo a lípidos  es la determinación de sustancias reactivas al ácido tiobarbitúrico (TBARs),  producto final de la peroxidación lipídica. Octopus  tehuelchus es un importante recurso pesquero en la costa patagónica,  expuesto en algunas áreas a contaminación antrópica. Dado que el estudio de parámetros  de estrés oxidativo aún no ha sido abordado en esta Clase de moluscos y que en  muchos modelos biológicos, los contaminantes ambientales actúan generando estrés  oxidativo, es clave encontrar sus blancos de acción, para empezar a  caracterizar las alteraciones metabólicas y fisiológicas asociadas a su  mecanismo de acción. El objetivo de este trabajo fue la puesta a punto del  método de determinación de daño oxidativo a lípidos en distintos tejidos del  pulpo Octopus tehuelchus desde  modelos previamente ensayados en el laboratorio  ","palabras_clave":"ESTRES OXIDATIVO|MALONDIALDHEIDO|OCTOPUS TEHUELCHUS|CEFALOPODOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88799,"idioma_id":5,"titulo":"'Mineralización de talco asociada a los cuerpos ultramáficos de la Faja del Río de Las Tunas, Cordillera Frontal de Mendoza'","resumen":"This contribution shows the main characteristics of the talc mineralization  related to the Río de Las Tunas ultramafic bodies in the Salamanca Mining District, Frontal Cordillera of Mendoza  province. According to the parageneses defined on the studied samples, three generations of talc were established:  1º) crystallized in metaperidotites and related to the prograde stage of the regional metamorphism; 2º) crystallized in  reaction zones (mostly in the talc zone) developed at the boundary between metaperidotites and their country-rocks.  These reaction zones evidence a metasomatic process due to geochemical gradient between the ultramafic body and their country-rocks. This process was developed during the retrogression of the regional metamorphic cycle.  3º) Talc present in shear-zones that cut across the ultramafic bodies. The extreme serpentinization of the ultramafic bodies is concentrated in shear-zones where the serpentine is subsequently replaced by talc ± carbonates related with a hydrothermal stage. Aqueous fluids relatively enriched in CO2 flowed through these shear-zones causing the cease of serpentine formation favoring the talc and\/or carbonates. Mined talc deposits are those in shear zones and reaction zones. They are mostly industrial-, asbestine- or talcschist-type. The talc related to the hydrothermal stage can locally reach first and extra qualities.","palabras_clave":"Talc|Ultramafic|Cordillera Frontal|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88800,"idioma_id":4,"titulo":"Sol-gel immobilized ovarian follicles: collaboration between two different cell types in hormone production and secretion","resumen":"The immobilization of mammalian cells within semipermeable matrices which allow retention ofviability and functionality has recently attracted research interest. In this study, rat mature ovarianfollicles were encapsulated in sol\u2013gel silica matrices for the evaluation of in vitro steroid hormones production. Tetraethoxysilane (TEOS) and tetrakis(2-hydroxyethyl)orthosilicate (THEOS) wereevaluated for cell viability, progesterone and estradiol secretion and cell structure conservation.Significant differences were observed between TEOS and THEOS, which allowed encapsulation offollicles for 9 days. Although encapsulated follicles showed lower viability and proliferation rates thancontrol follicles, they were able to secrete estradiol to the same extent as control follicles. This studydemonstrated an effective collaboration between two different mammalian cell types in hormoneproduction and secretion when encapsulated in silica matrices. These results could lead to thedevelopment of ovarian cell-based hormone delivery systems for the treatment of the symptoms ofmenopause and the Turner syndrome minimizing adverse effects.production. Tetraethoxysilane (TEOS) and tetrakis(2-hydroxyethyl)orthosilicate (THEOS) wereevaluated for cell viability, progesterone and estradiol secretion and cell structure conservation.Significant differences were observed between TEOS and THEOS, which allowed encapsulation offollicles for 9 days. Although encapsulated follicles showed lower viability and proliferation rates thancontrol follicles, they were able to secrete estradiol to the same extent as control follicles. This studydemonstrated an effective collaboration between two different mammalian cell types in hormoneproduction and secretion when encapsulated in silica matrices. These results could lead to thedevelopment of ovarian cell-based hormone delivery systems for the treatment of the symptoms ofmenopause and the Turner syndrome minimizing adverse effects.in vitro steroid hormones production. Tetraethoxysilane (TEOS) and tetrakis(2-hydroxyethyl)orthosilicate (THEOS) wereevaluated for cell viability, progesterone and estradiol secretion and cell structure conservation.Significant differences were observed between TEOS and THEOS, which allowed encapsulation offollicles for 9 days. Although encapsulated follicles showed lower viability and proliferation rates thancontrol follicles, they were able to secrete estradiol to the same extent as control follicles. This studydemonstrated an effective collaboration between two different mammalian cell types in hormoneproduction and secretion when encapsulated in silica matrices. These results could lead to thedevelopment of ovarian cell-based hormone delivery systems for the treatment of the symptoms ofmenopause and the Turner syndrome minimizing adverse effects.","palabras_clave":"sol-gel|ovarian follicles|immobilization|hormone production"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88801,"idioma_id":4,"titulo":"Polar Diels-Alder Reactions Developed in a Protic Ionic Liquid: 3-Nitroindole as Dienophile. Theoretical Studies Using DFT Methods","resumen":"N-Tosyl-3-nitroindole reacts with moderate and strong nucleophilic dienes in a polar Diels-Alder reaction using [HMIM][BF4] as a protic ionic liquid (PIL) as reaction media. In the cases in which the diene has oxygenated substituents, the PIL favors the aromatization of the formal [4+2] cycloadducts. Although the presence of the PIL in the reactions of N-tosyl-3-nitroindole as electrophile shows a clear tendency to the aromatization of the [4+2] cycloadducts, we do not note that the neoteric solvent increases the yields in relation with a molecular solvent. Part of this work is specifically concerned with theoretical studies using DFT reactivity indices. The global and local electrophilicity and nucleophilicity indices were calculated for N-tosyl-3-nitroindol and the dienes used in this study. For the studied reactions, the regioselectivity involved in the polar Diels-Alder reaction is well predicted.","palabras_clave":"Diels-Alder|Protic Ionic Liquid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88802,"idioma_id":5,"titulo":"'Evaluacion in vitro de aislamientos nativos de Trichoderma como agentes de biocontrol y promocion del crecimiento inicial en soja'","resumen":"En este trabajo se evaluaron in vitro aislamientos nativos de Trichoderma asperelum, T. harzianum y T. theobromicola como agentes de biocontrol de Fusarium semitectum Berkeley y Ravenel, Corynespora cassiicola (Berk. y Curt.) Wei y Diaporthe\/Phomopsis y como biopromotores del crecimiento inicial en soja. T. harzianum se destacó en el método de competencia por el sustrato. T. asperellum A1 y A2 en la producción de metabolitos solubles, mientras que T. asperellum A2 y T. theobromicola lo hicieron en la producción de metabolitos volátiles. Los antagonistas mostraron efecto parasítico por enrollamiento y formación de estructuras en forma de gancho. T. harzianum y T. asperellum, enfrentados a los patógenos, cubrieron la totalidad de la superficie de la placa de Petri y esporularon sobre el micelio de los patógenos. T. theobromicola cubrió el 50% de la superficie de la placa y el micelio no avanzó sobre los patógenos. Las semillas inoculadas con T. theobromicola y T. harzianum  incrementaron significativamente la energía germinativa y T. theobromicola incrementó el poder germinativo. No tuvieron efecto sobre la longitud de radículas y talluelos, pero indujeron una mayor producción de biomasa, con pesos secos de talluelos y raices significativamente superiores a los testigos.","palabras_clave":"BIOCONTROL|HONGOS ANTAGONISTAS|PROMOTORES DE CRECIMIENTO|TRICHODERMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88803,"idioma_id":4,"titulo":"Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: In vitro and in vivo studies","resumen":"Ethnopharmacological relevance: Zuccagnia punctata Cav. (Fabaceae) is a monotypic species distributed in western Argentina and is traditionally used for the treatment of bacterial and fungal infections. The aim of this study was to demonstrated the antibacterial activity of the Zuccagnia punctata standardized extract and the structurally related non-methoxylated flavonoids with similar pattern of substitution and differences in ring C present in this plant species: 7-hydroxyflavanone (HF), 2,4-dihydroxychalcone (DHC) and 3,7-dihydroxyflavone (DHF), against Streptococcus pneumoniae clinical isolates using in vitro and in vivo models.Materials and Methods: MIC values of natural products were determined by agar macrodilution method.In vivo activities were investigated in a Streptococcus pneumoniae infection model in mice. Lung and blood samples were obtained for bacterial cell counts. The serum was used by biochemical analysis (alanine transaminase, aspartate transaminase, urea and creatinine) in order to evaluate the toxicity of natural products.Results: All samples showed antimicrobial activity in vitro with MIC values between 50 and 500 g\/ml. Zuccagnia punctata extract (1 mg\/mice) and HF (1 mg\/mice) significantly reduced the number of viable Streptococcus pneumoniae in lung (p &lt; 0.01) while lower quantities has not effect. Therefore, the present study has shown that intake once or twice a day of 1 mg of Zuccagnia punctata extract or HF for seven days did not result in toxicity.Conclusions: Our results showed that Zuccagnia punctata extract as well as one of its isolated flavonoids, 7-hydroxyflavanone, could be useful for the development of a novel respiratory infections treatment.","palabras_clave":"ZUCCAGNIA PUNCTATA 7-HYDROXYFLAVANONE |2´,4´-DIHYDROXYCHALCONE 3´,7´-DIHYDROXYFLAVONE |ANTIMICROBIAL ACTIVITY |STREPTOCOCCUS PNEUMONIAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88804,"idioma_id":4,"titulo":"Probiotics for Everyone! The Novel Immunobiotic Lactobacillus rhamnosus CRL1505 and the Beginning of Social Probiotic Programs in Argentina","resumen":"Lactobacillus rhamnosus CRL1505 (Lr1505) stimulates immune responses in the gut and in the respiratorytract and improves resistance against Salmonella typhimurium and Streptococcus pneumoniae infections inimmunocompetent and immunocompromised mice. Considering that respiratory infectious diseases continue to be amajor cause of death among preschool children in developing countries, the aim of the present study was to evaluate theeffect of Lr1505 on the health of children. A randomized-controlled double-blind clinical trial in 298 healthy children (2-5years old), attending daycare centers was performed. Yogurt containing Lr1505 was administered to children for 6months (five times a week). Results were statistically compared with those of children from the same community thatreceived a placebo yogurt (without probiotic). Administration of Lr1505 to young children reduced the incidence ofinfections: 66% of children in the placebo group presented symptoms of infection while only 34% of cases were detectedin the Lr1505 group. Significant differences (P&lt;0.05) were detected in the incidence of intestinal infections, upperrespiratory tract infections and angina when placebo and Lr1505 groups were compared. Children fed Lr1505experienced fewer fevers and needed fewer antibiotics than those receiving the placebo. The protective effect of Lr1505was associated with increased levels of mucosal IgA antibodies. Lr1505 is a promising resource for the development ofprevention strategies against mucosal infections that could be effective tools for medical application. This new probioticstrain has been included into official Nutritional Programs in Argentina and it is given to more than 200 thousandchildren. This project has encouraged local milk production, thanks to the constant demand of probiotic yogurt containingL. rhamnosus CRL1505 by provincial governments, while incorporating innovation to small and medium enterprises.","palabras_clave":"Lactobacillus rhamnosus CRL1505|children|mucosal immunity|respiratory infections"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88805,"idioma_id":5,"titulo":"LACTOBACILLUS RHAMNOSUS CRL1505 EL PRIMER PROBIÓTICO SOCIAL","resumen":"El tracto respiratorio es una importante vía de entrada de microorganismos patógenos, muchos de los cuales inician allí su replicación, diseminándose luego al resto del organismo. Las infecciones del tracto respiratorio tanto virales como bacterianas, son una de las principales causas de muerte en niños durante los primeros años de vida. Las bacterias lácticas (BL) constituyen un grupo importante de microorganismos probióticos cuyo uso está muy difundido debido a sus propiedades bene&#9251;ciosas sobre la salud. Numerosos trabajos de investigación han demostrado que las BL tienen efectos protectores contra las infecciones bacterianas y virales en el tracto gastrointestinal. Nos propusimos como objetivo de nuestras investigaciones evaluar los efectos de un Yogur Probiótico que contiene la cepa L. rhamnosus CRL1505 en la salud de los niños que asisten a centros comunitarios de zonas con necesidades básicas insatisfechas de la Provincia de Tucumán. Se evaluó el impacto del Yogur Probiótico en la inmunidad de mucosas y se estudió su efecto sobre la incidencia y severidad de infecciones gastrointestinales y respiratorias. Este nuevo alimento probiótico ha sido incluido en programas O&#9251;ciales de Nutrición en la Argentina. Desde 2008, el yogur probiótico que contiene L. rhamnosus CRL1505 (YOGURITO®) se administra diariamente a más de 200 mil niños en Tucumán.","palabras_clave":"Lactobacillus rhamnosus CRL1505|probiótico social|CERELA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88806,"idioma_id":4,"titulo":"Ionic Liquids and Microwave irradiation as synergistic combination for Polar Diels-Alder Reactions using properly substituted Heterocycles as Dienophiles. A DFT study related","resumen":"For the DA reactions between nitropyrrole derivatives and isoprene, the combination of microwave irradiation  and protic ionic liquids, has a notable synergistic effect. DFT calculations suggest that a supplementary  energy ranking in the IR region of 1.700?1400 cm1 can favour the structural changes in the  reactants to reach the TS.","palabras_clave":"DIELS-ALDER|IONIC LIQUIDS|MICROWAVE|NITROPYRROLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88807,"idioma_id":4,"titulo":"Antifungal Activity of Eugenol Analogues. Influence of Different Substituents and Studies on Mechanism of Action","resumen":"Abstract: Twenty one phenylpropanoids (including eugenol and safrole) and synthetic analogues, thirteen of them new compounds, were evaluated for antifungal properties, first with non-targeted assays against a panel of human opportunistic pathogenic fungi. Some structure-activity relationships could be observed, mainly related to the influence of an allyl substituent at C-4, an OH group at C-1 and an OCH3 at C-2 or the presence of one or two NO2 groups in different positions of the benzene ring. All active compounds were tested in a second panel of clinical isolates of C. albicans and non-albicans Candida spp., Cryptococcus neoformans and dermatophytes. The eugenol derivative 4-allyl-2-methoxy-5-nitrophenol (2) was the most active structure against all strains tested, and therefore it was submitted to targeted assays. These studies showed that the antifungal activity of 2 was not reversed in the presence of an osmotic support such as sorbitol, suggesting that it does not act by inhibiting the fungal cell wall synthesis or assembly. On the other hand, the Ergosterol Assay showed that 2 did not bind to the main sterol of the fungal membrane up to 250 µg mL&#8722;1. In contrast, a 22% of fungal membrane damage was observed at concentrations = 1 × MIC and 71% at 4× MIC, when 2 was tested in the Cellular Leakage assay. The comparison of log P and MICs for all compounds revealed that the antifungal activity of the eugenol analogues would not to be related to lipophilicity.","palabras_clave":"eugenol derivatives|antifungal activity|mechanism of antifungal action|lipophilicity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88808,"idioma_id":4,"titulo":"A new phenanthrene-based bis-oxime chemosensor for Fe (III) and Cr (III) discrimination","resumen":"The synthesis of two new 2,7-disubstituted phenanthrene-based bis oximes is described. The ability of these two compound for complexing heavy metal cations have been studied and complexation constants and complex stoichiometry for Cr3+ and Fe3+ complex have been determined. The fluorescent properties of ligand 2 make this compound able to act as a sensor able to discriminate between Cr3+ and Fe3+. Detection limits for these two cations have been evaluated.","palabras_clave":"CHEMOSENSOR| DIOXIME| CHROMIUN| IRON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88809,"idioma_id":5,"titulo":"Bulygin y los errores de la Filosofía del Derecho: ¿influye la moral sobre la normatividad?","resumen":"  La revista 'Perspectivas de las Ciencias Económicas y Jurídicas'  se encuentra indizada en Latindex Directorio y en CLASE y posee circulación  nacional.                      Resumen:            El problema de la relación entre el derecho y la moral es una  preocupación recurrente para los iusfilósofos de todas las corrientes. Hasta el  presente, múltiples y variadas respuestas han sido atisbadas aunque ninguna ha  logrado ser definitiva.           &nbsp;     En este artículo, se presentan las reflexiones publicadas por el  exponente argentino Eugenio Bulygin en su artículo '¿Está (parte de) la  filosofía del derecho basada en un error?'. Allí, el autor, desde una  perspectiva positivista, indaga sobre las posibilidades de la filosofía del  derecho de dar cuenta exitosamente sobre cuestiones como el valor moral del  derecho o el deber moral de obedecer las normas y concluye que estos  interrogantes son materia de la filosofía moral. A partir de esta idea, otras  temáticas se ven involucradas, directa o indirectamente, tales como la  aplicabilidad de las normas, las lagunas axiológicas y las dicotomías en el  desarrollo de la tarea judicial.          ","palabras_clave":"POSITIVISMO JURÍDICO|NORMATIVIDAD|MORAL|EXCLUSIVE POSITIVISM|INCLUSIVE POSITIVISM|APLICABILIDAD NORMATIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88810,"idioma_id":5,"titulo":"Procesos de flexibilización de las relaciones laborales y la negociación colectiva en Argentina. Continuidades y rupturas desde la implementación del programa neoliberal.","resumen":"El presente artículo tiene como objetivo establecer las continuidades y rupturas de las prácticas de gestión de la fuerza de trabajo vinculadas a las lógicas de flexibilidad laboral durante los dos periodos 1990-2002 y 2003-2011. Para ello tomamos como emergente empírico al sector automotriz argentino en esas etapas a partir del análisis comparativo de las negociaciones colectivas de trabajo celebradas entre las diferentes firmas del sector y las entidades sindicales respectivas. En los primeros apartados se precisa el corpus conceptual utilizado para la comprensión de la temática investigada para luego desarrollar las características del caso específico como ejemplo paradigmático en tanto sector productivo emblemático de la estructura productiva argentina.","palabras_clave":"RELACIONES DEL TRABAJO|SINDICALISMO|FLEXIBILIDAD|NEGOCIACIÓN COLECTIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88811,"idioma_id":4,"titulo":"Histologic and histomorphometric study of bone repair under acute Trypanosoma cruzi  infection in rats","resumen":"Trypanosoma cruzi (T. cruzi) is an intracellular protozoan pathogen that causes American trypanosomiasis (Chagas disease).The aim of this study was to evaluate the histopathological effects of acute infection by T. cruzi on bone repair. Wistar rats were used throughout. The animals were assigned to two groups: Control Group (CG n =20) and Experimental Group (EG n =20). All the animals were anesthetized, at t0 the first lower right molar was extracted. The EG animals were inoculated subcutaneously at t0 with 0.1 mL of 105 trypomastigotes of the virulent strain Tulahuen of T. cruzi. The CG animals were administered an equivalent volume of saline solution subcutaneously. The animals in both groups were euthanized at 15 days post-infection and tooth extraction. The mandibles were resected, fixed in formalin solution, radiographed, decalcified and embedded in paraffin. Bucco-lingually oriented sections were obtained at the level of the mesial tooth socket of the first lower molar, and stained with hematoxylin-eosin. Total alveolar volume (TV) and bone volume (TBV\/TV) in the apical third of the tooth socket were evaluated histomorphometrically. The histological analysis revealed an alteration in post-extraction bone tissue repair in animals infected by T. cruzi. A reduction in osteogenic activity was observed concomitant with a rise in quiescent and eroded bone surfaces. Histomorphometric evaluation revealed a significant reduction (19%) in total alveolar volume (TV) and bone volume (TBV\/TV) (24%) in the apical third of the tooth socket in animals infected with T. cruzi in comparison to non-infected animals (p&lt;0.05). The results obtained using this experimental model showed decreased osteogenesis in bone tissue repair under acute Trypanosoma cruzi infection in rats. ","palabras_clave":"ALVEOLAR RIDGE|WOUND HEALING|BONE|OSTEOGENESIS|TOOTH SOCKET|TRYPANOSOMA CRUZI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88812,"idioma_id":4,"titulo":"Biomarkers in sepsis at time zero: intensive care unit scores, plasma measurements and polymorphisms in Argentina.","resumen":"A patient´s response to sepsis is influenced by their genetic background. Our objective was to use plasma markers, such as protein C (PC), D-dimer, Plasminogen Activator Inhibitor-1 (PAI-1) levels, and the PAI-1 rs1799889 4G\/5G and  Tumor Necrosis Factor-&#945; rs1800629 G\/A  polymorphisms to improve classical intensive care unit (ICU) scores.  METHODOLOGY:  We studied 380 subjects, 166 with sepsis. We performed coagulation tests: plasma PAI-1 and PC levels were evaluated by chromogenic methods; and D-dimer was evaluated by immunoturbidimetric assay. Polymorphisms were performed using for polymerase chain reactions followed by digest with specific restriction enzyme. We acquired the APACHE and SOFA scores (time zero), sex, age, body mass index, associated co-morbidities, length of ICU stay (days), the severity of sepsis (sepsis, severe sepsis or septic shock), the HIV status and the ICU outcome (survival or death).  RESULTS:  We found significant differences between patients who died (n=80) and those who survived (n=86) in terms of the ICU length of stay (6 vs. 10 days), septic shock (64 versus 24%), age (51 versus 38 years old), HIV+ condition (34 versus 16%), SOFA (7 versus 4), APACHE (19 versus 13), D-dimer (4.32 versus 2.88 mg\/ml), PC (46.0 versus 63.5 %) and PAI-1 (33.0 versus 16.5 UA\/l). When we used a regression analysis with dichotomized variables, only the SOFA4, PAI-116, HIV status and the PAI-1 4G allele proved to be predictors of death at time zero.","palabras_clave":"MARKERS|SPSIS|POLIMORPHISM|MORTALITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88813,"idioma_id":4,"titulo":"The -2518 A\/G polymorphism in the monocyte chemoattractant protein 1 gene is associated with the risk of developing systemic lupus erythematosus in Argentinean patients: a multicenter study.","resumen":"Systemic lupus erythematosus (SLE) is a systemic, autoimmune disorder. Monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the recruitment and migration of monocytes\/macrophages, has been shown to be increased in the plasma of SLE patients. The aim of our study was to evaluate the possible association of the polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and with other clinical features of SLE in an Argentinean population. A group of 171 SLE patients and 120 control subjects were examined. Genotypic and allelic frequencies of the MCP-1 -2518 A\/G polymorphism showed significant differences between the SLE and the control groups (p=0.001 and p=0.01, respectively). However, the polymorphism showed no association with LN or with the other clinical variables studied. Our results suggest that the presence of the MCP-1 -2518 A\/G polymorphism might be a risk factor for developing SLE in genetically predisposed individuals, but it does not seem to have a role in the evolution of the disease in the Argentinean population.","palabras_clave":"LUPUS|POLIMORPHISM|NEPHITIS|MCP-1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88814,"idioma_id":4,"titulo":"Aryl Hydrocarbon Receptor Activation by Aminoflavone: New molecular target for renal cancer treatment","resumen":"Background: Aminoflavone (AF; NSC 686288, AFP464, NSC710464) is a new anticancer drug that recently entered Phase II clinical trials. It has demonstrated antiproliferative effect in MCF-7 human breast cancer cells mediated by the aryl hydrocarbon receptor (AhR). AF also exhibits noteworthy evidence of antitumor activity in vitro and in vivo against neoplastic cells of renal origin. AF treatment of sensitive renal cells, in contrast to resistant cells, promotes CYP1A1 induction, covalent binding of AF-reactive intermediates and apoptosis. Based on this evidence, the aim of this study was to evaluate the role of AhR, main transcriptional regulator of CYP1A1, in the antiproliferative effect of AF in human renal cancer cells. Methods: AF-citoxicity in human renal cell lines and a renal cancer cell strain was assessed by MTS assays in the presence or absence of an Ahr inhibitor. Drug-induced AhR nuclear translocation was evaluated by western blot of AhR in cytosolic and nuclear fractions and by measuring XRE-driven luciferase activity. Apoptosis induced by the drug was evaluated by DAPI and Acridine orange\/Ethidium bromide staining and by measuring p-P53 and P21 levels, Caspase 3 activation and PARP cleavage. Results: AF inhibited cell growth in a dose dependent manner in TK-10, Caki-1, SN12-c, and A498 human renal cells but not in ACHN cells. The antiproliferative effect of AF was abrogated by preincubation of TK-10, Caki-1 and SN12-C cells with the AhR antagonist, á-naphtoflavone. AF treatment also induced apoptosis in TK-10, Caki-1 and SN12-C, which was not observed in ACHN cells. AF induced time dependent AhR nuclear translocation and AhR transcriptional activity in sensitive renal cancer cell lines. Also, a renal cell strain derived from a human papillary tumor was sensitive to AF and showed AhR pathway activation and drug induced apoptosis. Conclusions: AhR translocation could be included as a marker of sensitivity to AF in sensitive renal tumor cells of different histological origin, in the ongoing phase II clinical trials","palabras_clave":"ARYL HYDROCARBON RECEPTOR|AMINOFLAVONE|RENAL RECEPTOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88815,"idioma_id":5,"titulo":"Discurso y liderazgo político: género y juventud en la legitimación de Camila Vallejo","resumen":"Esta revista está indizada en CLASE (Citas  Latinoamericanas en Ciencias Sociales y Humanidades), sistema de Información  Latindex Directorio y Catálogo, RedALyC y EBSCO. Su circulación es  internacional. Categoría CIRC: C.        &nbsp;        Resumen:              La propuesta de  este trabajo es analizar el discurso de asunción a la presidencia de la FECh de  Camila Vallejo como líder política. En este discurso político aparecen las  bases sobre las que la candidata consagrada erigió eficazmente su legitimidad y  que, principalmente, se centran en su calidad de joven, estudiante y mujer. Es,  precisamente, el relevamiento de la significación de estas temáticas el objeto  de este trabajo. A su vez, los dichos pronunciados en esta pieza textual serán  contrastados con noticias aparecidas en la prensa nacional e internacional a  efectos de señalar la relevancia que han adquirido.            En cuanto al  marco teórico, se realiza un análisis de la pieza textual emitida por Vallejo  como discurso político y a las noticias periodísticas como un tipo específico  de discurso con una estructura textual propia.         &nbsp;        ","palabras_clave":"Discurso |juventud|liderazgo político|género"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88816,"idioma_id":4,"titulo":"Optical response of silver nanoparticles stabilized by amines to LSPR based sensors","resumen":"Silver nanoparticles aminosilane capped were obtained as stable colloids. FTIR spectrum of these nanoparticles showed astrong interaction between amine groups and silver surface, being this property the source of the high stability of thecolloidal particles. UV-visible spectrum showed the typical absorption owing the resonance of localized surface plasmon(LSPR). We show that the optical properties of the colloidal nanoparticles were influenced by medium conditions. Acontinuous shift of the maximum of absorption to longer wavelength was observed with the enhancement of Pb2+ andCd2+concentrations. In this way, these nanoparticles can be used as LSPR sensors.","palabras_clave":"nanoparticles|LSPR|sensors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88817,"idioma_id":4,"titulo":"N-tosyl-nitropyrroles as Dienophiles in Polar Cycloaddition Reactions Developed in Protic Ionic Liquids","resumen":"N-tosyl-2-nitropirrole and N-tosyl-3-nitropirrole reacts with poorly and activated dienes using protic ionic liquids as reactionmedia. They exhibit a dienophilic character producing the corresponding indoles through a Diels-Alder process. In all cases thepresence of protic ionic liquids as reaction media improve the yields respect to the use of molecular solvent, while the temperature andthe reaction time decrease. A similar behavior was observed in disubstituted N-tosyl-pyrroles.","palabras_clave":"NITROPYRROLES|INDOLES|IONIC LIQUIDS|DIELS-ALDER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88818,"idioma_id":4,"titulo":"Rural People's Knowledge and Perception of Landscape: A Case Study From the Mexican Pacific Coast","resumen":"no disponible","palabras_clave":"rural people|perception|landscape|Pacific Coast"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88819,"idioma_id":5,"titulo":"Primacía de la voluntad y virtud moral en Juan Duns Escoto","resumen":"El siguiente artículo analiza la doctrina de Duns Escoto referida al sujeto de las virtudes morales, y plantea la fuerte influencia que ha tenido en ella la aceptación hecha por parte del Doctor Subtilis de las tesis voluntaristas presentes en su época. La revista se encuentra indizada en SCOPUS, ELSEVIER, SCIELO, REDALyC, DOAJ, REDIB, EBSCO, The Philosopher´s Index, Répertoire bibliographique de la philosophie, DIALNET, Latindex, Filos, Clase.","palabras_clave":"VOLUNTARISMO|VIRTUD MORAL|JUAN DUNS ESCOTO|FILOSOFIA MORAL|SIGLO XIV"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88820,"idioma_id":4,"titulo":"Mathematical modeling of the heat and mass transfer in a stationary potato sphere impinged by a single round liquid jet in a hydrofluidization system","resumen":"The hydrofluidization (HF) is a method of chilling and freezing of foods which consists in a circulating system that pumps a refrigerating liquid upwards through orifices or nozzles, creating agitating jets. The objectives of this work were to develop a mathematical model to represent the combined heat and mass transfer between a food and a refrigerant liquid medium in a HF system and to validate the model using a single stationary sphere of food impinged by a single round jet of liquid. The food domain consisted of a rigid solid matrix, a liquid phase and the ice phase. Transport equations were applied to each phase and solved by a control-volume approach. The transport phenomena in the fluid domain were studied by computational fluid dynamics. The surface heat transfer coefficients obtained from fluid flow simulations were used to model the heat and mass transfer inside the food. Experimental central temperature and average solute uptake profiles were obtained when potato spheres were placed in a HF system using a NaCl-water as refrigerant and considering different temperatures (-10 and -15ºC), flow rates (1 and 3 L min-1), and orifice-sphere distances (1 and 5 cm). The predicted values agreed well with the experimental ones, the maximum root mean square errors being 3.3 g NaCl kg-1 potato and 2.9 K for the average solute concentration and temperature profiles studied, respectively. The simulations improved the understanding of the HF process and it may help to study and control different operation scenarios.","palabras_clave":"MATHEMATICAL MODEL|HEAT AND MASS TRANSFER|HYDROFLUIDIZATION|FOOD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88821,"idioma_id":4,"titulo":"The influence of elevated initial ripening temperature on the proteolysis in Reggianito cheese","resumen":"The effects of elevated initial ripening temperature on proteolysis in Reggianito cheese were evaluated considering different temperature-time combinations. Control cheeses stored at 12°C for 6 months and experimental cheeses stored at 20°C for 2 or 4 weeks then at 12°C up to 6 months, were analysed at 61, 124, and 180 days of ripening by physicochemical analysis, urea-PAGE analysis of the urea-soluble fraction, RP-HPLC analysis on the water-soluble fraction at pH 4.6, and free amino acid analysis. In general, increasing ripening temperature and time resulted in increases of proteolysis products, notably higher levels being observed in experimental cheeses initially stored at 20°C for 4 weeks. Principal component analysis showed that those cheeses at 124 days of ripening had similar levels of proteolysis products to the control cheeses at 180 days of ripening. In conclusion, promising results related to the proteolysis event in Reggianito cheese were obtained, which may help in the selection of a convenient elevated temperature-time combination for accelerating its ripening.","palabras_clave":"REGGIANITO|CHEESE|PROTEOLYSIS|RIPENING|ELEVATED TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88822,"idioma_id":4,"titulo":"Effect of protective atmospheres on physicochemical, microbiological and rheological characteristics of sliced Mozzarella cheese","resumen":"Mozzarella cheese slices packaged in bags of polyvinylidene chloride under vacuum (V) and using a gas mixture of equal parts of CO2 and N2 (G) were stored at 4°C for 8 weeks and analysed at different storage times by physicochemical, microbiological and rheological characterization. Expected values of moisture, total nitrogen, soluble nitrogen at pH 4.6, and chloride contents and of pH were observed. The degradation of as1-casein was greater than b-casein degradation, while no significant differences were observed due to the packaging methods. Coliform microorganisms were not detected, while levels of moulds and yeasts counts were acceptable. Expected values of total mesophile counts were obtained. The temperature at crossover moduli (Tc) was determined from temperature sweeps carried out by rheometry. Greater values of Tc were observed in samples G. The influence of temperature on complex viscosity was studied by an Arrhenius-type equation. Activation energy values were obtained from the solid-like region (20°C - 40°C) and liquid-like region (40°C - 60°C). A more rapid change in viscosity with temperature was observed when storage time increased and when storage method V was used. ","palabras_clave":"MOZZARELLA CHEESE|PROTECTIVE ATMOSPHERES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88823,"idioma_id":4,"titulo":"Landscape responses to a century of land use along the northern Patagonian forest-steppe transition","resumen":"Land use history reconstructions in temperate regions of the Northern Hemisphere indicate that periods of deforestation are often followed by natural afforestation, so that the long-term outcome at the landscape level will be a balance of retractions and advances of plant communities associated with varying local land uses. During the last decades of the XIX century, large forest areas were cleared in Northwestern Patagonia to open farmland. In this article, we compared historical land use\/land cover maps with land cover maps derived from Landsat images to analyze the factors that may have influenced the dynamics of land cover change of the forest-steppe ecotone during the last 100 years. Our results indicate that   Patagonian forests underwent a rapid initial recovery after the extensive fires of last century, replacing mainly shrublands. More than 50% of the old burns are currently covered by forests, and modern fires affect areas characterized by fire-prone vegetation. Whereas natural afforestation is an ongoing process positively associated with moisture, the rate of forest losses has increased during the last three decades, concentrating on xeric aspects and the vicinity of roads. We conclude that the outcome of the dynamics between fire-intolerant forests and fire-prone plant communities will largely depend on human-related activities, modeled by structural features of the landscape (i.e., topography, dominant winds), and processes triggered by past land uses.","palabras_clave":"Forest expansion|Anthropogenic impacts|Fire|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88824,"idioma_id":4,"titulo":"Decreases in fire spread probability with forest age promotes alternative community states, reduced resilience to climate variability and large fire regime shifts","resumen":"The generalization that plant communities increase in flammability as they age and invariably lead to resilient self-organized landscape mosaics is being increasingly challenged. Plant communities often exhibit rapidly saturating or even hump-shaped age-flammability trajectories and landscapes often display strong non-linear behaviors, abrupt shifts, and self-reinforcing alternative community states. This plethora of fire-landscape interactions calls for a more general model that considers alternative age-flammability rules. We simulated landscape dynamics assuming communities that (1) increase in flammability with age and (2) gain flammability up to a certain age followed by a slight and moderate loss to a constant value. Simulations were run under combinations of ignition frequency and interannual climatic variability. Age-increasing fire probability promoted high resilience to changes in ignition frequency and climatic variability whereas humpbacked-shaped age-flammability led to strong non-linear behaviors. Moderate (20%) reductions in mature compared to peak flammability produced the least resilient behaviors. The relatively nonflammable mature forest matrix intersected by young flammable patches is prone to break up and disintegrate with slight increases in ignition\/climate variability causing large-scale shifts in the fire regime because large fires were able to sweep through the more continuous young\/flammable landscape. Contrary to the dominant perception, fire suppression in landscapes with positive feedbacks may effectively reduce fire occurrence by allowing less flammable later stage communities composed of longer lived, obligate seeders to replace earlier stages of light demanding, often more flammable resprouters. Conversely, increases in anthropogenic ignitions, a common global trend of many forested regions may, in synergism with increased climate variability, induce abrupt shifts, and large-scale forest degradation.","palabras_clave":"FIRE-LANDSCAPE INTERACTIONS|POSITIVE FEEDBACKS|SELF-ORGANIZED BEHAVIOR|PERCOLATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88825,"idioma_id":4,"titulo":"MODELLING PHYTOPHTHORA DISEASE RISK  IN AUSTROCEDRUS CHILENSIS FORESTS OF PATAGONIA","resumen":"Austrocedrus chilensis forests suffer from a disease caused by Phytophthora austrocedrae which is found often in wet soils. We applied three widely used modelling techniques, with different data requirements, to model disease potential distribution under current environmental conditions: Mahalanobis distance, Maxent and Logistic regression. Each model was built using field data of health condition and landscape layers of environmental conditions (distance to streams, slope, aspect, elevation, mean annual precipitation and soil pH NaF). We compared model predictions by area under the receiver operating characteristic curve (AUC) and Kappa statistics. A reasonable ability to predict observed disease distribution was found for each of the three modelling techniques. However, Maxent and Logistic Regression presented the best predictive performance, with significant differences with respect to the Mahalanobis distance model. Our results suggested that if good absence data is available, logistic regression should be used in order to better discriminate sites with high risk of disease. On the other hand, if absence data is not available or it is doubtful, Maxent could be a very good option.  The three models predicted that around 50% (49-56%) of the currently asymptomatic forests are located on sites at risk of disease according to abiotic factors. Most of these asymptomatic forests surround the current diseased patches, at distances lower than 100 m from diseased patches. Management considerations and the scope of future studies were discussed in this paper.    (Aclaración: el trabajo fue aceptado con cambios menores en 2010, y aceptado en forma definitiva en Febrero 2011)","palabras_clave":"MAL DEL CIPRÉS|RISK MODEL|MAHALANOBIS DISTANCE|MAXENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88826,"idioma_id":4,"titulo":"Mortality of the outbreak defoliator Ormiscodes amphimone (Lepidoptera: Saturniidae) caused by natural enemies in northwestern Patagonia, Argentina","resumen":"Outbreaks of the defoliator moth Ormiscodes amphimone are occurring more frequently in numerous Nothofagus forests of Patagonia. However, little is known about the life history of this species including its natural enemies as mortality agents. In this work we quantified mortality by parasitoids and generalist predators at the egg, larval and pupal life stages of O. amphimone in a Nothofagus pumilio (Poepp. and Endl.) Krasser forest in northwestern Patagonia. Parasitism of eggs was relatively low (ca. 11 %), and we did not record significant larval predation by insectivorous birds. However, we recorded elevated mortality caused by larval parasitoids (ca. 50 % in third instar larvae) and pupal predators (ca. 75 %), which suggests that these natural enemies could play a significant role in regulating O. amphimone populations. Our research is an initial step towards understanding the influence of natural enemies on O. amphimone population dynamics.","palabras_clave":"ENTOMOPATHOGENIC NEMATODE|HYPOSOTER|NOTHOFAGUS|PARASITOIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88827,"idioma_id":4,"titulo":"Ecological niche modeling meets phylogeography to unravel hidden past history of key forest genera in plant geography: Podocarpus and Nothofagus","resumen":"Phylogeographical methods and ecological niche modeling of cold-tolerant taxa, Podocarpus parlatorei a montane tropical conifer and Nothofagus pumilio inhabiting temperate areas of the southern Andes, were used as case studies to test if present populations are the result of local survival during cooling. Samples collected along their ranges were analyzed by nuclear isozymes and uniparentally inherited chloroplast DNA sequences. Modern and past last glacial maximum (LGM) ecological niche modeling (ENM) was developed using current climate data based on 19 bioclimatic variables and topography. Populations of the subtropical of P. parlatorei shared most haplotypes, southern populations were genetically distinct, and ENM yielded range expansion during the LGM. Latitudinally extreme populations of the temperate N. pumilio shared isozyme variants which was consistent with ENM showing suitable northern and southern areas. In contrast cpDNA yielded an ancient phylogeographic structure. Cold-hardy trees locally persisted along their ranges through ice periods without major range shifts in tropical and temperate regions.","palabras_clave":"Chloroplast DNA|Cold-tolerant Trees|Distribution Modeling|Montane Subtropical|Temperate Andes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88829,"idioma_id":4,"titulo":"Computational study and spectroscopic  investigations of antihypertensive drugs","resumen":"Sartans are orally active non-peptide molecules that competitively block the access of the AT1 receptor  to angiotensin II used to treat hypertension and related pathologies. In particular, candesartan and valsartan are currently used in clinical therapy, and it is of interest to characterize them and their anionic  forms under physiological conditions by means of their vibrational properties. The Fourier transform  Raman (FT-Raman) and Fourier transform infrared (FTIR) spectra of candesartan, valsartan in their protonated and deprotonated forms were recorded in the solid phase. The vibrational wavenumbers, infrared  intensities and Raman scattering activities were calculated by density functional B3LYP method with  the 6-31+G(d,p) basis set, and theoretical spectrograms have been constructed. The scaled theoretical  wavenumbers showed very good agreement with the experimental values. A detailed interpretations of  the infrared and Raman spectra were performed for both the synthetic and the bioactive drugs.","palabras_clave":"ANTIHYPERTENSIVE DRUGS|FTIR|FT-RAMAN|DENSITY FUNCTIONAL CALCULATIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88830,"idioma_id":4,"titulo":"Folic acid and safflower oil supplementation interacts and protects embryos from maternal diabetes-induced damage","resumen":"Maternal diabetes increases the risk for embryo malformations. Folic acid and safflower oil supplementations have been shown to reduce embryo malformations in experimental models of diabetes. We here tested whether folic acid and safflower oil supplementations interact to prevent embryo malformations in diabetic rats, and analyzed whether they act through the regulation of matrix metalloproteinases (MMPs), their endogenous inhibitors (TIMPs), and nitric oxide and reactive oxygen species production. Diabetes was induced by streptozotocin administration prior to mating. From day 0.5 of pregnancy, rats received or not folic acid (15 mg\/kg) and\/or a 6% safflower oil-supplemented diet. Embryos and decidua were explanted on day 10.5 of gestation for further analysis of embryo resorptions and malformations, MMP-2 and MMP-9 activities, TIMP-1 and TIMP-2 levels, nitric oxide production and lipid peroxidation. Maternal diabetes induced resorptions and malformations that were prevented by folic acid and safflower oil supplementation. MMP-2 and MMP-9 activities were increased in embryos and decidua from diabetic rats and decreased with safflower oil and folic acid supplementations. In diabetic animals, the embryonic and decidual TIMPs were increased mainly with safflower oil supplementation in decidua and with folic acid in embryos. Nitric oxide overproduction was decreased in decidua from diabetic rats treated with folic acid alone and in combination with safflower oil. These treatments also prevented increases in embryonic and decidual lipid peroxidation. In conclusion, folic acid and safflower oil supplementations interact and protect the embryos from diabetes-induced damage through several pathways related to a decrease in pro-inflammatory mediators.","palabras_clave":"Diabetes|malformaciones congénitas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88831,"idioma_id":5,"titulo":"Premio Prof. Dr. Abraham Guitelman La activación de receptores activados por proliferadores peroxisomales (PPARs) como reguladora del metabolismo lipídico en la placenta de pacientes con diabetes","resumen":"Dadas las alteraciones metabólicas inducidas por la diabetes materna y la capacidad de los receptores nucleares PPARs de regular el metabolismo lipídico se propuso como objetivo evaluar los niveles de lípidos y PPARs en la placenta de pacientes sanas y con diabetes tipo 2, y determinar si la activación de PPARs regula los niveles y peroxidación lipídica en dichos tejidos. Metodología: Las placentas fueron obtenidas luego del alumbramiento, se determinaron los niveles de lípidos mediante cromatografía, los niveles de PPARs mediante Western blot y&nbsp; la peroxidación lipídica mediante la cuantificación de TBARS. Resultados: Se evidenciaron mayores niveles de lípidos y menores niveles de PPARa y PPARgamma en placenta de pacientes diabéticas en relación al control (P&lt;0,05). Agonistas de PPARa redujeron&nbsp; la masa lipídica en la placenta de pacientes sanas y diabéticas, mientras que la activación de PPARgamma la redujo sólo en la placenta de pacientes sanas. Al activar PPARgamma aumenta la masa lipídica y la expresión de la enzima de síntesis de ácidos grasos FASN (P&lt;0,05). La peroxidación lipídica, incrementada en placenta de pacientes diabéticas (P&lt;0,001), se reguló negativamente al activar los tres isotipos de PPARs (P&lt;0,05). Conclusión: Se identificaron en este estudio noveles funciones de PPARs en la placenta humana relevantes en la regulación del metabolismo lipídico y la lipoperoxidación. La diabetes tipo 2 induce a nivel placentario alteraciones en los niveles y función de PPARs vinculadas a las importantes anomalías en el metabolismo lipídico y un estado pro-oxidante inducidas por esta patología.   ","palabras_clave":"PLACENTA|PPAR|LIPIDOS|DIABETES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88832,"idioma_id":5,"titulo":"PERSPECTIVA DE APLICACIÓN DE LA SELECCIÓN GENÓMICA EN UN CRUZAMIENTO INTRAESPECÍFICO DE Eucalyptus grandis","resumen":"La perspectiva de acelerar y mejorar la precisión de la selección a través de marcadores en especies  forestales, ha llevado a que se apliquen diferentes metodologías para localizar los loci que afectan a los caracteres a mejorar. Por el contrario, la seleccióngenómica (SG) se basa en la estimación simultánea de los efectos de todos los marcadores disponibles a lo largo del genoma para predecir el valor de cría individual sin el conocimiento específico de los genes que contribuyen a un determinado carácter ni su ubicación. En especies forestales son escasos estos reportes y mayoritariamente se refierena estudios basados en simulaciones. Con el fin evaluar la factibilidad de realizar SG en progenies provenientes de cruzamientos controlados (práctica común en los programas de mejoramiento forestal avanzados) se utilizó el algoritmo Bayes Lasso (regresión lineal bayesiana) en un cruzamiento F1 de E. grandis con 131 individuos genotipificados con2378 DArT y 74 SSR. Se analizaron 50 particiones aleatorias 90-10 para la predicción de diámetro del fuste (DBH), altura del árbol (TH) y densidad de madera (DB) cuyas heredabilidades fueron 0,42, 0,35 y 0,68 respectivamente. Utilizando todos los marcadores, las medianas de las correlaciones entre el valor fenotípico predicho para cada árbol (cuyosfenotipos fueron enmascarados) y el valor fenotípico observado (la predicción BLUP del valor de cría más la media general) fueron 0,54 (DBH), 0,37 (HT) y 0,78 (DB). Mostrando que la SG es una estrategiaatractiva para el mejoramiento de densidad y crecimiento en este tipo de poblaciones","palabras_clave":"EUCALYPTUS|F2|SNPS|BAYES LASSO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88833,"idioma_id":4,"titulo":"High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin\/Na,K-ATPase complex","resumen":"Our previous studies demonstrated that acetylated tubulin forms a complex with Na+,K+-ATPase and thereby inhibits its enzyme activity in cultured COS and CAD cells. The enzyme activity was restored by treatment of cells with l-glutamate, which caused dissociation of the acetylated tubulin\/Na+,K+-ATPase complex. Addition of glucose, but not elimination of glutamate, led to re-formation of the complex and inhibition of the Na+,K+-ATPase activity. The purpose of the present study was to elucidate the mechanism underlying this effect of glucose. We found that exposure of cells to high glucose concentrations induced: (a) microtubule formation; (b) activation of aldose reductase by the microtubules; (c) association of tubulin with membrane; (d) formation of the acetylated tubulin\/Na+,K+-ATPase complex and consequent inhibition of enzyme activity. Exposure of cells to sorbitol caused similar effects. Studies on erythrocytes from diabetic patients and on tissues containing insulin-insensitive glucose transporters gave similar results. Na+,K+-ATPase activity was &gt;50% lower and membrane-associated tubulin content was &gt;200% higher in erythrocyte membranes from diabetic patients as compared with normal subjects. Immunoprecipitation analysis showed that acetylated tubulin was a constituent of a complex with Na+,K+-ATPase in erythrocyte membranes from diabetic patients. Based on these findings, we propose a mechanism whereby glucose triggers a synergistic effect of tubulin and sorbitol, leading to activation of aldose reductase, microtubule formation, and consequent Na+,K+-ATPase inhibition.+,K+-ATPase and thereby inhibits its enzyme activity in cultured COS and CAD cells. The enzyme activity was restored by treatment of cells with l-glutamate, which caused dissociation of the acetylated tubulin\/Na+,K+-ATPase complex. Addition of glucose, but not elimination of glutamate, led to re-formation of the complex and inhibition of the Na+,K+-ATPase activity. The purpose of the present study was to elucidate the mechanism underlying this effect of glucose. We found that exposure of cells to high glucose concentrations induced: (a) microtubule formation; (b) activation of aldose reductase by the microtubules; (c) association of tubulin with membrane; (d) formation of the acetylated tubulin\/Na+,K+-ATPase complex and consequent inhibition of enzyme activity. Exposure of cells to sorbitol caused similar effects. Studies on erythrocytes from diabetic patients and on tissues containing insulin-insensitive glucose transporters gave similar results. Na+,K+-ATPase activity was &gt;50% lower and membrane-associated tubulin content was &gt;200% higher in erythrocyte membranes from diabetic patients as compared with normal subjects. Immunoprecipitation analysis showed that acetylated tubulin was a constituent of a complex with Na+,K+-ATPase in erythrocyte membranes from diabetic patients. Based on these findings, we propose a mechanism whereby glucose triggers a synergistic effect of tubulin and sorbitol, leading to activation of aldose reductase, microtubule formation, and consequent Na+,K+-ATPase inhibition.","palabras_clave":"Na+,K+-ATPase|ACETYLATED TUBULIN|DIABETES|MICROTUBULES|HUMAN ERYTHROCYTES|ALDOSE REDUCTASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88834,"idioma_id":4,"titulo":"Effect of beta-Li3N phase, Li2O addition and thermal treatment on the hydrogen sorption behavior of Li3N","resumen":"The hydriding of Li3N to LiNH2 is investigated to clarify the influence of the beta-Li3N phase, the addition of Li2O and the thermal treatment of Li3N on the hydrogen storage properties of the Li-N-H system. As-milled Li3N displays fast initial absorption that is attributed to the formation of beta-Li3N nanograins, the increase of the surface area, and the presence of surface defects induced by mechanical milling. However, further hydrogen absorption is retarded in comparison with the as-received sample due to the presence of the beta-Li3N phase formed during milling. Thus, commercial Li3N exhibits the highest hydrogen storage capacity in the first cycle in comparison with as-heated Li3N and as-milled samples. In the case of Li2O addition, no interaction with Li3N was detected. The addition of LiH to the commercial Li3N, as-milled Li3N and Li3N-Li2O influences only the stability of the samples under hydrogen cycling. The hydrogen absorption\/desorption behavior is mainly controlled by the amount of beta-Li3N formed during milling, while at long times the microstructure has a minor effect.","palabras_clave":"HYDROGEN STORAGE|LITHIUM NITRIDE|MECHANICAL MILLING|LITHIUM OXIDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88835,"idioma_id":4,"titulo":"Optimization of culture medium composition for manganese peroxidase and tyrosinase production during Reactive Black 5 decolourization by the yeast Trichosporon akiyoshidainum","resumen":"Decolourization and degradation of the diazo dye Reactive Black 5 was carried out by the yeast Trichosporon akiyoshidainum. A nine-factor Plackett?Burman design was employed for the study and optimization of the decolourization process and production of manganese peroxidase (MnP) and tyrosinase activities. In the present study, 26 individual experiments were conducted and three responses were evaluated. Raising yeast extract concentration significantly enhanced decolourization and MnP production. Carbon and nitrogen sources, glucose and (NH4)2SO4, showed no significant effect on any response over the concentration range tested. Other culture medium components, such as CaCl2 or MgSO4, could be excluded from the medium formula, as they had no effect on the evaluated responses. Metal ions (Fe, Cu and Mn) showed different effects on decolourization and enzymatic activities. Addition of copper significantly enhanced MnP activity and decreased dye decolourization. On the contrary, iron had a positive effect on decolourization and no effect on enzyme production. Oddly, increasing manganese concentration had a positive effect on tyrosinase production without affecting decolourization or MnP activity. These results strongly suggest that dye decolourization should be regarded as a complex multi-enzymatic process, where optimal medium composition should arise as a compromise between those optimal for each implied enzyme production","palabras_clave":"Mn-peroxidase and tyrosinase|Optimization of culture medium |Reactive Black 5 decolourization|Trichosporon akiyoshidainum."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88836,"idioma_id":4,"titulo":"Changes in rheology, structure and water mobility of apple tissue as result of osmotic dehydration with glucose or trehalose","resumen":"The impact of osmotic dehydration to water activity (a&nbsp;w) at 0.97 or 0.94 with glucose or trehalose solutions on structure (optical and transmission electronic microscopy observations), rheological properties (small-scale dynamic oscillatory and creep\/recovery measurements and large-scale compression force-deformation testing) and water mobility (1H-NMR spectra) of parenchymatous apple tissue was investigated. In general, the nature and the concentration of sugar employed significantly affected the material properties and the structure of apple tissue. A dramatic loss in rigidity (E&nbsp;d); an increase in deformation at rupture (ƒÃ&nbsp;R&nbsp;R), creep compliances (J&nbsp;0,&nbsp;J&nbsp;1, and&nbsp;J&nbsp;2), and fluidity (1\/ƒÅ&nbsp;0) and a decrease in storage (G?Œ) and loss (G??) moduli, true rupture stress (ƒÐ&nbsp;R&nbsp;R), and proton transverse relaxation times (T&nbsp;2i) were induced by osmotic treatments.&nbsp;ƒÃ&nbsp;R&nbsp;R,&nbsp;C&nbsp;1, and&nbsp;T&nbsp;2iparameters allowed to discriminate between the sugars used as osmotic agents while the different&nbsp;aw&nbsp;levels for each sugar resulted in changes in&nbsp;ƒÐ&nbsp;R&nbsp;R,&nbsp;W, and&nbsp;T&nbsp;2i&nbsp;values. Loss of turgor due to plasmolysis or rupture of membranes and desorganization\/degradation of walls allowed explaining, at least partially, the changes in material parameters.","palabras_clave":"Apple|Osmosis|Glucose|Trehalose|Water mobility|Rheology|Structure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88837,"idioma_id":4,"titulo":"Characterization of StABF1, a stress-responsive bZIP transcription factor from Solanum tuberosum L. that is phosphorylated by StCDPK2 in vitro","resumen":"  Abstract ABF\/AREB bZIP transcription factors mediate plant abiotic stress responses by regulating the expression of stress-related genes. These proteins bind to the abscisic acid (ABA)-responsive element (ABRE), which is the major cis-acting regulatory sequence in ABA-dependent gene expression. In an effort to understand the molecular mechanisms of abiotic stress resistance in cultivated potato (Solanum tuberosum L.), we have cloned and characterized an ABF\/AREB-like transcription factor from potato, named StABF1. The predicted protein shares 45?57% identity with A. thaliana ABFs proteins and 96% identity with the S. lycopersicum SlAREB1 and presents all of the distinctive features of ABF\/AREB transcription factors. Furthermore, StABF1 is able to bind to the ABRE in vitro. StABF1 gene is induced in response to ABA, drought, salt stress and cold, suggesting that it might be a key regulator of ABA-dependent stress signaling pathways in cultivated potato. StABF1 is phosphorylated in response to ABA and salt stress in a calcium-dependent manner, and we have identified a potato CDPK isoform (StCDPK2) that phosphorylates StABF1 in vitro. Interestingly, StABF1 expression is increased during tuber development and by tuber-inducing conditions (high sucrose\/nitrogen ratio) in leaves. We also found that StABF1calcium-dependent phosphorylation is stimulated by tuberinducing  conditions and inhibited by gibberellic acid, which inhibits tuberization.ABF\/AREB bZIP transcription factors mediate plant abiotic stress responses by regulating the expression of stress-related genes. These proteins bind to the abscisic acid (ABA)-responsive element (ABRE), which is the major cis-acting regulatory sequence in ABA-dependent gene expression. In an effort to understand the molecular mechanisms of abiotic stress resistance in cultivated potato (Solanum tuberosum L.), we have cloned and characterized an ABF\/AREB-like transcription factor from potato, named StABF1. The predicted protein shares 45?57% identity with A. thaliana ABFs proteins and 96% identity with the S. lycopersicum SlAREB1 and presents all of the distinctive features of ABF\/AREB transcription factors. Furthermore, StABF1 is able to bind to the ABRE in vitro. StABF1 gene is induced in response to ABA, drought, salt stress and cold, suggesting that it might be a key regulator of ABA-dependent stress signaling pathways in cultivated potato. StABF1 is phosphorylated in response to ABA and salt stress in a calcium-dependent manner, and we have identified a potato CDPK isoform (StCDPK2) that phosphorylates StABF1 in vitro. Interestingly, StABF1 expression is increased during tuber development and by tuber-inducing conditions (high sucrose\/nitrogen ratio) in leaves. We also found that StABF1calcium-dependent phosphorylation is stimulated by tuberinducing  conditions and inhibited by gibberellic acid, which inhibits tuberization.","palabras_clave":"StABF1|Solanum tuberosum L.|Abscisic acid|Abiotic stress"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88838,"idioma_id":4,"titulo":"Synergistic Effect Between Two Bacteriocin-like Inhibitory Substances Produced by Lactobacilli Strains with Inhibitory Activity for Streptococcus agalactiae","resumen":"Group B streptococci (GBS) are bacterial species that colonize the vagina in pregnant women and as such may cause serious infections in neonates that passed through the birth channel. The objective of this work was to study the inhibitory activities produced by each bacteriocin- like inhibitory substance (BLIS) of Lactobacillus rhamnosus L60 and Lactobacillus fermentum L23, and the effects of the combined BLIS-es of these lactobacilli on GBS. The interactions between the BLIS-es were assessed by qualitative and quantitative methods on agar plates. The minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs) were determined by a modification of the broth microdilution and checkerboard methods, respectively. Antibiotic susceptibilities of all S. agalactiae strains were assayed and the results of these tests were evaluated for statistical significance. A 7.5% of GBS isolates were recovered from 760 pregnant women and 91% of those strains were susceptible to each BLIS produced by L. fermentum, L. rhamnosus, and also to a mixture of them. The comparisons among the BLIS-es showed statistically significant differences, with a combination of the BLIS-es from the two Lactobacillus species being better than the BLIS of each one alone (P&#65533;.05) as GBS growth inhibitors. Synergistic activities between the BLIS-es were found on 100% of susceptible GBS strains, MICs ranges of BLIS of L23 and L60 were 80?160 and 160?320 UA ml-1, respectively. By the checkerboard method, the BLIS-es combination showed synergistic effect on all sensitive strains tested, with values of FICs ranging from 0.131 to 0.218. The BLIS-es produced by these lactobacilli of vaginal origin were able to inhibit S. agalactiae isolates. The results indicate that these strains may have probiotic potential for the control of GBS in women and may consequently prevent GBS infections in newborns.","palabras_clave":"Bacteriocin- like inhibitory substance |Lactobacillus|Streptococcus agalactiae|Synergistic effect"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88839,"idioma_id":4,"titulo":"In vitro biological control for Lactic Acid Bacteria isolated from brewer's grains","resumen":"Los residuos de cervecería son  suplementos de bajo costo y de fácil disponibilidad,  sin embargo, el alto contenido de  humedad los hace susceptibles a la degradación  fúngica y al desarrollo de microorganismos  patógenos. Las bacterias ácido lácticas  (BAL) se encuentran formando parte de la  microbiota de los granos de cebada, de manera  tal, que podrían contribuir en la calidad y  seguridad tanto de la malta como de los productos  derivados. El objetivo de este estudio  fue determinar la presencia BAL, especies  fúngicas de Aspergillus sección Flavi, Listeria  monocytogenes e incidencia de aflatoxina B1  (AFB1) en residuos de cervecería, y evaluar  in vitro el efecto antifúngico y anti-aflatoxicogénico  de las BAL. El análisis de los residuos  de cervecería mostró que, en general, los recuentos  de BAL fueron elevados durante todos  los períodos analizados, sin embargo, el  recuento de Aspergillus sección Flavi, L. monocytogenes  e incidencia natural de AFB1 fue  variable. El hallazgo de L. monocytogenes  es el primero informado en Argentina en este  tipo de sustrato. Lactobacillus coryniformis  subsp. coryniformis L47 y Lactobacillus cellobiosus  L56 fueron las cepas más efectivas en  inhibir el crecimiento y la producción de AFB1  de todas las cepas de Aspergillus sección  Flavi ensayadas in vitro. Futuros estudios con  estas cepas de BAL podrían realizarse para  demostrar su efectividad in situ en estos sustratos  alternativos destinados a la producción  animal, así como también evaluar in vitro sus  propiedades anti-listeria.","palabras_clave":"LACTIC ACID BACTERIA |ASPERGILLUS SECTION FLAVI|LISTERIA MONOCYTOGENES|BIOCONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88840,"idioma_id":4,"titulo":"Detection and kinetic analysis of Epinotia aporema granulovirus in its lepidopteran host by real-time PCR","resumen":"Epinotia aporema granulovirus (EpapGV) has attracted interest as a potential biocontrol agent of the soybean pest Epinotia aporema in Argentina. Studies on virus\/host interactions conducted so far have lacked an accurate method to assess the progress of virus load during the infection process. The present paper reports the development of a real-time PCR for EpapGV and its application to describe viral kinetics following ingestion of two different virus doses by last-instar E. aporema larvae. Real-time PCR was shown to be a reliable method to detect and quantify the presence of EpapGV in the analyzed samples. The increase in virus titer (log) exhibited a sigmoidal pattern, with an exponential growth phase between 24 and 48 h postinfection for both initial doses tested.","palabras_clave":"BACULOVIRUS|KINETIC|DIAGNOSTIC|PCR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88841,"idioma_id":4,"titulo":"Occurrence of hourglass dolphin (Lagenorhynchus cruciger) and habitat characteristics along the Patagonian Shelf and the Atlantic Ocean sector of the Southern Ocean","resumen":"The hourglass dolphin,Lagenorhynchus cruciger,is one of the smallest cetaceans found in Antarctic waters. Although frequently observed, this is one of the least studied species of dolphin. In this study, we investigate the occurrence of hourglass dolphin in the South West Atlantic and Southern Ocean from 42ºS to 63ºS and characterize the oceanographic and environmental features associated with their occurrence. Sighting data was collected during two scientific cruises in December 2009 and January and February 2011 and integrated into a geographical information system with environmental variables such as sea surface temperature, ocean colour, depth, distance to oceanographic fronts and distance from shore. We used a principal component analysis (PCA) to identify patterns in data and a non-hierarchic cluster analysis  to classify observations into groups. A total of 19 sightings (96 individuals) were recorded. Group size ranged from one to twelve dolphins (mean 5.05). We could differentiate two groups in relation to theenvironmental conditions where animals were found, one group occurring in shallow coastal waters and the other occurring in deeper and colder waters further offshore. The present study contributes novel information on environmental measures associated with hourglass dolphin distribution in the Southwest Atlantic and Southern Oceans. Additionally, it includes relatively high sighting clusters of this species in two highly productive and biodiverse areas (Burdwood Bank\/Isla de los Estados and the South Shetland Islands)","palabras_clave":"HOURGLASS DOLPHIN|CETACEAN DISTRIBUTION|OCEANOGRAPHY|SOUTH WEST ATLANTIC OCEAN|SOUTHERN OCEAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88842,"idioma_id":4,"titulo":"Good Protection but Excessive Pulmonary Inflammation in Balb\/C Mice Vaccinated with Mycobacterium Bovis mce-2A Mutant after Challenge with Homologous Strains","resumen":"bstract ","palabras_clave":"tuberculosis|mycobacteria|mce2|pathogenesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88843,"idioma_id":5,"titulo":"Recría de bovinos de carne con dietas basadas en granos de maíz o avena pelletizados","resumen":"Este experimento fue diseñado para comparar la respuesta productiva y parámetros sanguíneos de dos grupos de novillitos recriados en confinamiento recibiendo dietas basadas en grano de maíz o grano de avena pelletizados.","palabras_clave":"AVENA|MAÍZ|BOVINOS DE CARNE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88844,"idioma_id":4,"titulo":"The cytochrome b(5) dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.","resumen":"Tetrahymena thermophila is a free-living ciliate with no exogenous sterol requirement. However, it can perform several modifications on externally added sterols including desaturation at C5(6), C7(8), and C22(23). Sterol desaturases in Tetrahymena are microsomal enzymes that require Cyt b5, Cyt b5 reductase, oxygen, and reduced NAD(P)H for their activity, and some of the genes encoding these functions have recently been identified. The DES5A gene encodes a C-5(6) sterol desaturase, as shown by gene knockout in Tetrahymena. To confirm and extend that result, and to develop new approaches to gene characterization in Tetrahymena, we have now, expressed DES5A in Saccharomyces cerevisiae. The DES5A gene was codon optimized and expressed in a yeast mutant, erg3D, which is disrupted for the gene encoding the S. cerevisiae C-5(6) sterol desaturase ERG3. The complemented strain was able to accumulate 74% of the wild type level of ergosterol, and also lost the hypersensitivity to cycloheximide associated with the lack of ERG3 function. C-5(6) sterol desaturases are expected to function at the endoplasmic reticulum. Consistent with this, a GFP-tagged copy of Des5Ap was localized to the endoplasmic reticulum inboth Tetrahymena and yeast. This work shows for the first time that both function and localization are conserved for a microsomal enzyme between ciliates and fungi, notwithstanding the enormous evolutionary distance between these lineages. The results suggest that heterologous expression of ciliate genes in S. cerevisiae provides a useful tool for the characterization of genes in Tetrahymena, including genes encoding membrane protein complexes.","palabras_clave":"C-5(6) STEROL DESATURASE|TETRAHYMENA|ENDOPLASMIC RETICULUM|COMPLEMENTATION|SACCHAROMYCES CEREVISIAE|ERGOSTEROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88845,"idioma_id":4,"titulo":"Yeast and yeast-like fungi associated with dry indehiscent fruits of a tree species in patagonia, Argentina.","resumen":"Nothofagus nervosa (Rauli) is a native tree species that yields valuable timber. It was overexploited in the past and is currently included in domestication and conservation programs. Several research programs have focused on the characterization of epiphytic microorganisms because it has been demonstrated that they can affect plant-pathogen interactions and\/or promote plant growth. Although the microbial ecology of leaves has been well studied, less is known about microorganisms occurring on seeds and noncommercial fruits. In this work, we analyzed the yeast and yeast-like fungi present on N. nervosa fruits destined for the propagation of this species, as well as the effects of fruit preservation and seed dormancy-breaking processes on fungal diversity. Morphological and molecular methods were used, and differences between fungal communities were analyzed using a similarity index. A total of 171 isolates corresponding to 17 species were recovered, most of which belong to the phylum Ascomycota. The majority of the species develop mycelia, produce pigments and mycosporines, and these adaptation strategies are discussed. It was observed that the preservation process considerably reduced yeast and yeast-like fungal diversity. This is the first study concerning microbial communities associated with this ecologically and economically important species, and the information presented is relevant to domestication programs.","palabras_clave":"RAULI, PHYLLOSPHERE|TREE DOMESTICATION, NONCOMMERCIAL FRUITS|FRUIT-BORNE FUNGI| POTENTIAL BIOCONTROL AGENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88846,"idioma_id":4,"titulo":"Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1\/MYC Promoters","resumen":"                      Synthetic progesterone used in  contraception drugs (progestins) can promote breast cancer growth, but the mechanisms  involved are unknown. Moreover, it remains unclear whether cytoplasmic  interactions between the progesterone receptor (PR) and estrogen receptor alpha  (ERa) are required for PR activation. In this study, we used a murine  progestin-dependent tumor to investigate the role of ERa in progestin-induced  tumor cell proliferation. We found that treatment with the progestin  medroxyprogesterone acetate (MPA) induced the expression and activation of ERa,  as well as rapid nuclear colocalization of activated ERawith PR. Treatment with  the pure antiestrogen fulvestrant to block ERa disrupted the interaction of ERa  and PR in vitro and induced the regression of MPA-dependent tumor growth in  vivo. ERa blockade also prevented an MPA-induced increase in CYCLIN D1 (CCND1)  and MYC expression. Chromatin immunoprecipitation studies showed that MPA  triggered binding of ERa and PR to the CCND1 and MYC promoters. Interestingly,  blockade or RNAi-mediated silencing of ERa inhibited ERa, but not PR binding to  both regulatory sequences, indicating that an interaction between ERa and PR at  these sites is necessary for MPA-induced gene expression and cell  proliferation. We confirmed that nuclear colocalization of both receptors also  occurred in human breast cancer samples. Together, our findings argued that  ERa\u2013PR association on target gene promoters is essential for progestin-induced  cell proliferation.  ","palabras_clave":"ESTROGEN RECEPTOR ALPHA |CYCLIN D1\/MYC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88847,"idioma_id":4,"titulo":"Effect of feed contamination with aflatoxin B1 and administration of exogenous corticosterone on Japanese quail biochemical and immunological parameters","resumen":"      Stress is  the loss of homeostasis by external forces or stressors. Manipulation, transport,  contamination and other procedures involved in production could be considered  stressors. Contamination is a problem commonly faced by producers in poultry  industry. Aflatoxicosis is one of the most usual infections resulting from feed  contaminated with Aspergillus flavus and A.  parasiticus. This study evaluated the potential effects of the  combined administration of aflatoxin B1 (AFB1) and  corticosterone on biochemical (concentration of globulins, proteins and  albumin) and immunological (inflammatory response and heterophil ? lymphocyte  ratio) parameters of Japanese quail. Potential gender effects on those parameters were  also considered. The provision of corticosterone in drinking water is a  method used for mimicking the effects of chronic stress in avian species. At 35 d of  age, 24 mixed-sex groups of 4 animals (2 males and 2 females) were housed in  cages and assigned to one of four treatments: plain drinking water and laying diet,  corticosterone administration in drinking water, feed contamination with AFB1  (100ug\/kg of feed), or corticosterone plus AFB1 administration. There  were 6 cages per treatment. No significant effect of gender in any of the  parameters analyzed was detected. Hypoproteinaemia, hypoalbuminaemia and  hypoglobulinaemia were observed in animals treated with  corticosterone or contaminated feed. These responses were exacerbated when the  factors were combined. The immunodepressive effect of corticosterone  administration was confirmed and a higher effect was noticed when combined with  the aflatoxin contamination. Aflatoxin contamination affected bird´s physiology  similarly to a chronic stressor stimulation since it elevates the heterophil -  lymphocyte ratio. This study suggests that the effects of the AFB1 contamination  are further increased when overlapped with a chronic stressful stimulation and  emphasizes the importance of controlling potential stressor combinations during  animal rearing to preserve not only the animal?s health status but also their  welfare.","palabras_clave":"AFLATOXIN CONTAMINATE|CORTICORTERONE |STRESS RESPONSE|JAPANESE QUAIL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88848,"idioma_id":4,"titulo":"Antifungal activity of two Lactobacillus strains with potential probiotic properties","resumen":"Aflatoxin (highly toxic and carcinogenic secondary metabolites produced byfingi) contamination is a serious problem worldwide. Modern agriculture andanimal production systems need to use high-quality and mycotoxin-free feedstuffs.The use of microorganisms to preserve food has gained importance inrecent years due to the demand for reduced use of chemical preservatives byconsumers. Lactic acid bacteria are known to produce various antimicrobialcompounds that are considered to be important in the biopreservation of foodand feed. Lactobacillus rhamnosus L60 and Lactobacillus fermentum L23 are producersof secondary metabolites, such as organic acids, bacteriocins and, in thecase of L60, hydrogen peroxide. The antifungal activity of lactobacilli strainswas determined by coculture with Aspergillus section Flavi strains by two qualitativeand one quantitative methods. Both L23 and L60 completely inhibitedthe fungal growth of all aflatoxicogenic strains assayed. Aflatoxin B1 productionwas reduced 95.7?99.8% with L60 and 27.5?100% with L23. Statistical analysisof the data revealed the influence of L60 and L23 on growth parameters andaflatoxin B1 production. These results are important given that these aflatoxicogenicfungi are natural contaminants of feed used for animal production,and could be effectively controlled by Lactobacillus L60 and L23 strains withprobiotic properties.","palabras_clave":"LACTOBACILLUS RAMNOSUS|LACTOBACILLUS FERMENTUM|ASPERGILLUS SECTION FLAVI|AFLATOXINA B1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88849,"idioma_id":4,"titulo":"Modelling the effect of temperature and water activity of Aspergillus flavus isolates from corn","resumen":"The aim of this study was to model the effects of temperature (10?40 °C) and aw (0.80?0.98), in two media  (Czapek yeast agar: CYA; corn extract medium: CEM) on the growth rates and growth boundaries (growth?  no growth interface) of three strains of A. flavus isolated from corn in Argentina. Both kinetic and probability  models were applied to colony growth data. The growth rates obtained in CYA were significantly (pb0.05)  greater than those obtained in CEM medium. No significant differences (pb0.05) were observed among  the three isolates. The growth rate data showed a good fit to the Rosso cardinal models combined with the  gamma-concept with R2=0.98?0.99 and RMSE=0.60?0.78, depending on media and isolates. The probability  model allowed prediction of safe storage (p of growth b0.01) for one month for moist maize (e.g. 0.90 aw)  provided temperature is under 15 °C, or for dry maize (e.g. 0.80 aw) provided temperature is under 27 °C.  Storage at b0.77 aw would be safe regardless of the storage temperature. Probability models allow evaluation  of the risk of fungal contamination in the process of storage, so the results obtained in this study may be useful  for application in systems of food safety management.","palabras_clave":"ASPERGILLUS FLAVUS|KINETIC MODEL|PROBABILITY MODEL|AW-TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88850,"idioma_id":4,"titulo":"Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process","resumen":"The objectives of this investigation were to evaluate the ability of Saccharomyces cerevisiae CECT 1891 andLactobacillus acidophilus 24 to remove fumonisin B1 (FB1) from liquid medium; to determine the nature ofthe mechanism involved in FB1?microorganism interaction and to analyze whether the presence of aflatoxinB1 (AFB1) interferes with the removal of FB1 and vice versa. The results obtained indicated that: (i) both microorganismswere able to remove FB1 from liquid medium; (ii) the removal was a fast and reversibleprocess; (iii) cell viability was not necessary; (iv) the amount of FB1 removed was both toxin- and microorganismconcentration-dependent; (v) the process did not involve chemical modification of FB1 molecules;and (vi) cell wall structural integrity of the microorganisms was required for FB1 removal. Consequently,we propose that the mechanism involved in the removal of FB1 is a physical adsorption (physisorption) ofthe toxin molecule to cell wall components of the microorganisms. It is highly probable that FB1 and AFB1co-occur in contaminated foods, since the fungal genera Aspergillus and Fusarium frequently occur simultaneously.Therefore, we analyzed whether the presence of AFB1 interferes with the removal of FB1 by the microorganismspreviously evaluated, and vice versa. Studies of co-occurrence of both mycotoxins clearlyshowed that they did not compete for binding sites on the microorganism cell wall and the presence ofone toxin did not modify the efficiency of the organism in the removal of the other mycotoxin. These findingsmay be useful for optimization of mycotoxin binding and provide an important contribution to research onmicroorganisms with ability to remove these secondary metabolites.","palabras_clave":"SACCHAROMYCES CEREVISIAE |LACTIC ACID BACTERIA|FUMONISIN B1-AFLATOXIN B1|PHYSICAL ABSORPTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88851,"idioma_id":4,"titulo":"Efficient spin control in high-quality-factor planar microcavities","resumen":"A semiconductor microcavity embedding donor impurities and excited by a laser field is modeled. By including general decay and dephasing processes, in particular, cavity photon leakage, detailed simulations show that control over the spin dynamics is significantly enhanced in high-quality-factor cavities, in which case picosecond laser pulses may produce spin flip with high-fidelity final states.","palabras_clave":"quantum wells|quantum computation|photoluminescence|materilas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88852,"idioma_id":4,"titulo":"Effective Hamiltonian for the impurity-impurity interaction in micropillars in the presence of decoherence","resumen":"We study the optically induced effective interaction between spins in micropillars. Our theoretical model describes a circularly polarized cavity mode strongly coupled to two quantum-dot excitons, each of which interacts with a localized spin. The decoherence effect inducing a finite lifetime to the cavity mode is included. Using the master equation for the density matrix we investigate the dynamics under low-power excitation. In the absence of decoherence, we recover the result obtained in a previous work (which uses conventional low-energy reduction procedures) for an effective Hamiltonian containing a Zeeman term and an Ising interaction between the localized spins. For finite cavity-photon lifetime we employ Fourier analysis on the time dependence of the nondiagonal element of the reduced density matrix, obtained by tracing out the photons and excitons, to find a quasieffective spin-spin Ising Hamiltonian. This Hamiltonian is a possible building block for two-qubit quantum computing operation. We study how decoherence affects the construction of that effective interaction. Finally, we discuss the possible application for transition-metal impurity spins embedded in CdTe quantum dots.","palabras_clave":"SPIN|DENSITY MATRIX|EXCITONS|QUANTUM COMPUTING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88853,"idioma_id":4,"titulo":"Reproductive pattern of Southern geoduck, Panopea abbreviata, at El Sótano (San Matías Gulf, Patagonia, Argentina)","resumen":"The reproductive cycle of the southern geoduck (Panopea abbreviata) in a northern Patagonian population was studied throughout a 24-month period (April 2006April 2008) using standard histological techniques and quantitative indicators(oocyte diameter distribution, oocytes per ocular field and relative oocyte area). P. abbreviata exhibits a reproductive pattern characterized, in both sexes, by a continuous proliferation and spawning throughout the year. This is similar to that described in southern geoduck populations and is unique to this genus. Quantitative indicators allowed us to elucidate a slight seasonality in the reproductive cycle: a more pronounced spawning during warm months and gamete accumulation during could months. This article describes the first record of hermaphroditic individuals (n 4) for P. abbreviata.","palabras_clave":"Reproductive cycle|Geoduck|Panopea"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88854,"idioma_id":4,"titulo":"Ostrea puelchana (D'Orbigny 1842): a new host of Tumidotheres maculatus (Say, 1818) in northern Patagonia, Argentina","resumen":"Tumidotheres maculatus has been reported as a commensal of Mytilus platensis and Atrina seminuda and suggested as a parasite of Aequipecten tehuelchus in San Matías Gulf (SMG). The native flat oyster, Ostrea puelchana, has been studied in SMG for decades, and no crab-oyster association has been reported. In autumn-spring 2009 and 2010, oysters were collected from four banks in SMG, and the occurrence of T. maculatus inside the pallial cavity of O. puelchana was recorded. The prevalence varied between sites, with 0-12.5% at El Sótano, 0-16.7% at Caleta de los Loros, and no crabs found in the samples from Las Grutas and Puerto Lobos. Infected oysters hosted a single crab. Oysters were infested by either one male (47.7%) or one female (15.1%). A positive but low correlation was found for male crab size and oyster size. The presence of these crabs inside the oysters could be due to the overlap of the distribution areas of O. puelchana and other bivalve hosts. Our findings may also be a consequence of local fishing. Commercial extraction of traditional hosts may have caused crabs to look for new hosts.","palabras_clave":"Oyster|Pinnotheridae|Comansalism|San Matias Gulf"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88855,"idioma_id":4,"titulo":"Stress response to high osmolarity in Trypanosoma cruzi epimastigotes","resumen":"Trypanosoma cruzi undergoes differentiation in the rectum of   triatomine, where increased osmolarity is caused mainly by elevated   content of NaCl from urine. Early biochemical events in response to high   osmolarity in this parasite have not been totally elucidated. In order   to clarify the relationship between these events and developmental   stages of T. cruzi, epimastigotes were subjected to hyperosmotic stress, which caused activation of Na+\/H+ exchanger from acidic vacuoles and accumulation of inositol trisphosphate (InsP3). Suppression of InsP3 levels was observed in presence of intracellular Ca2+   chelator or pre-treatment with 5-(N-ethyl-N-isopropyl)-amiloride   (EIPA), which also inhibited the alkalinization of acidic vacuoles via a   Na+\/H+ exchanger and the consequent increase in   cytosolic calcium. These effects were activated and inhibited by PMA and   Chelerythrine respectively, suggesting regulation by protein kinase C.   The T. cruzi Na+\/H+ exchanger, TcNHE1,   has 11 transmembrane domains and is localized in acidic vacuoles of   epimastigotes. The analyzed biochemical changes were correlated with   morphological changes, including an increase in the size of   acidocalcisomes and subsequent differentiation to an intermediate form.   Both processes were delayed when TcNHE1 was inhibited by EIPA,   suggesting that these early biochemical events allow the parasite to   adapt to conditions faced in the rectum of the insect vector","palabras_clave":"Hyperosmotic stress|Metacyclogenesis|Na+\/H+ exchanger|Phospholipase C"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88856,"idioma_id":4,"titulo":"Evolution of copper nanospecies in the synthesis stages of MCM-41 type mesoporous molecular sieves,","resumen":"The redox behavior of copper nanospecies in the synthesis stages of MCM-41-type materials has been followed by ESR technique. These copper modified mesoporous molecular sieves (Cu-MMS) were synthesized by direct incorporation method, and different treatments of the initial synthesis gel were evaluated. From ESR and UVvis-DRS data, a synergistic approach about the distribution of copper species in the different catalysts has been made: the hydrothermal treatment favors the incorporation of isolated cooper species into the framework, whereas both the aging treatment and the lack of subsequent treatment promote the formation of copper clusters into the mesoporous channels. The Hamiltonian parameters have confirmed the presence of isolated Cu2+ ions in octahedral coordination with tetragonal distortion within siliceous framework, whereas the g 2.2 value was assigned to the presence of Cu2+ clusters. Only the catalyst aged at room temperature has presented additional signals characteristic of Cu2+ dimers. Finally, it is found that during the template removal process at 773 K the so-called self-reduction phenomenon of isolated cupric ions takes place: a 50,70% decrease in the ESR signal intensity was observed for the final Cu-MMS.","palabras_clave":"MCM-41|COPPER NANOSPECIES|ESR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88857,"idioma_id":4,"titulo":"Influence of the Cr loading in Cr\/MCM-41 and TiO2\/Cr\/MCM-41 molecular sieves for the photodegradation of Acid Orange 7","resumen":"MCM-41 materials were modified with different Cr contents and then loaded with Ti by the wet impregnation method. The samples were characterized by XRD, XRF, N2 adsorption, UVvis-DR and TPR. Their photocatalytic activity was evaluated for the degradation of an Acid Orange 7 (AO7) aqueous solution irradiated by UV-Vis and only visible light. The presence of Cr6+ species highly dispersed on the MCM-41 structure had a significant influence on the photoactivity. With respect to the samples only loaded with Cr, a theoretical loading of 3.5 % wt. allowed an AO7 degradation percentage of around 70%. Higher loadings result in the incremented presence of Cr3+ inactive species, as clusters or &#945;-Cr2O3 nano-particles, producing no notable increase in the photoactivity. For its part, the presence of Ti in the samples with lower Cr loadings causes an increase in the AO7 degradation which could be associated to a heterojunction effect between active Cr6+ species and the titania. For the samples with higher Cr loadings, the lack of synergism could be due to the increased presence of inactive Cr3+ species that avoid this expected interaction.","palabras_clave":"HETEROGENEOUS PHOTOCATALYSIS|AZO-DYES|MCM-41|Cr-SPECIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88858,"idioma_id":5,"titulo":"?Aportes socio-antropológicos de las etnografías en hospitales psiquiátricos. Revisión de la bibliografía anglosajona y latinoamericana","resumen":"Resumen  El objetivo de este artículo es reseñar los principales aportes de las etnografías realizadas en hospitales psiquiátricos. En primer lugar se repasan las etnografías pioneras en el hospital psiquiátrico. Luego se presentan estudios   que problematizan la organización hospitalaria post reforma psiquiátrica, y se describen investigaciones que se   centran en los abordajes terapéuticos y el mundo de los profesionales. En tercer lugar se presentan algunos estudios en América Latina agrupados en líneas temáticas y por último se recupera una discusión conceptual sobre   modelos y prácticas institucionales contemporáneas. El artículo da cuenta de los principales aportes socio-antropológicos de los trabajos etnográficos reseñados, al tiempo que comenta las cuestiones metodológicas y éticas que   ponen en cuestión la realización de este tipo de abordajes.","palabras_clave":"ETNOGRAFIAS|HOSPITALES PSIQUIATRICOS|RESEÑA|BIBLIOGRAFICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88859,"idioma_id":4,"titulo":"Is livestock grazing compatible with amphibian diversity in the High Mountains of Córdoba, Argentina?","resumen":"    The High  Mountains of Córdoba, Argentina have a long evolutionary history of grazing by  large herbivores. However, about 400 years ago, European livestock were introduced  and gradually replaced native herbivores. Since the 1920s, domestic herbivores  have been the only large herbivores present in the area, causing severe soil  erosion and a threat to the system diversity. The endemic fauna of the region  includes four amphibian species. We evaluated the effect of livestock rearing  on amphibian diversity and water bodies in woodlands and grasslands of the High  Mountains of Córdoba. The work was conducted on stream stretches and ponds in  two contrasting grazing situations: an area with livestock presence and another  area where livestock was excluded 14 years ago. The following variables were  recorded at each sampling site: amphibian richness and abundance, percentage of  emergent, submerged and peripheral vegetation in areas surrounding the water  bodies, water pH, and water dissolved O2. No significant differences were detected  in amphibian diversity between streams of both grazing situations, whereas a  greater diversity p&lt;0.01) was observed in ponds in grazed grasslands. Our  results suggest that livestock rearing, qualitatively measured as grazing and  14 years of livestock exclusion, in the study area would not have negative  effects on amphibian diversity. This finding might be due to the long  evolutionary grazing history of the area, large-scale livestock exclusion  exhibiting a novel scenario. The ongoing reintroduction of native grazers may  provide the benefits of grazing without the consequent soil erosion and habitat  degradation associated with domestic livestock.","palabras_clave":"Amphibians|Grazing history|High Mountains of Córdoba|Livestock exclusion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88860,"idioma_id":4,"titulo":"On the facets of lift-and-project relaxations under graph operations","resumen":"We study the behavior of lift-and-project procedures for solving combinatorial optimization problems as described by Lovász and Schrijver (1991) in the context of the stable set problem on graphs. Following the work of Wolsey (1976), Lipták and Lovász (2001) and Lipták and Tunçel (2003), we investigate how to generate facets of the relaxations obtained by these procedures from facets of the relaxations of the original graph, after applying fundamental graph operations. We show our findings for the odd and the star subdivision, the stretching of a node and a new operation defined herein called the clique subdivision of an edge.","palabras_clave":"LIFT&PROJECT|COMBINATORIAL OPTIMIZATION|STABLE SET"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88861,"idioma_id":5,"titulo":"Biotransformación y Cromatografía","resumen":"Se presenta un trabajo práctico que tiene como uno de los principales objetivos impulsar acciones tendientes a enriquecer la habilidad de observación, análisis e interpretación de resultados obtenidos de la aplicación de la técnica cromatográfica en capa delgada.","palabras_clave":"cromatografía en capa delgada|biotransformación enzimática"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88862,"idioma_id":4,"titulo":"Tungstophosphoric acid supported on zirconia: A recyclable catalyst for the green synthesis on quinoxaline derivatives under solvent-free conditions","resumen":"Abstract A green, simple, and fast procedure has been developed for the preparation ofA green, simple, and fast procedure has been developed for the preparation of&nbsp;quinoxaline derivatives by a condensation of 1,2-diamines with 1,2-dicarbonyl compoundsquinoxaline derivatives by a condensation of 1,2-diamines with 1,2-dicarbonyl compounds&nbsp;in the presence of zirconium oxide modified with tungstophosphoric acid (H3PW12O40) asin the presence of zirconium oxide modified with tungstophosphoric acid (H3PW12O40) as&nbsp;a heterogeneous catalyst, in a solvent-free medium using conventional heating. Quinoxalinea heterogeneous catalyst, in a solvent-free medium using conventional heating. Quinoxaline&nbsp;derivatives were formed in short-time periods and excellent yields (65?100%). The reactionderivatives were formed in short-time periods and excellent yields (65?100%). The reaction&nbsp;work-up is very simple and the catalyst can be easily separated from the reaction mixturework-up is very simple and the catalyst can be easily separated from the reaction mixture&nbsp;and reused several times in subsequent reactions without appreciable loss of the catalyticand reused several times in subsequent reactions without appreciable loss of the catalyticactivity.activity.","palabras_clave":"Tungstophosphoric acid |supported on zirconia|quinoxaline derivatives |solvent-free conditions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88863,"idioma_id":4,"titulo":"Fungal Hydroxylation of (-)-&#945;-Santonin","resumen":"Functionalization of organic compounds using enzymes present in microorganisms is a very useful tool for organic chemists, since it is a method carried out under milder conditions than chemical ones and allows the introduction of functional groups in a nonreactive carbon in a regioselective and stereoselective way. In order to look for new compounds derived from natural products with antioxidant and cytotoxic activity, the sesquiterpene lactone (\u2013)-&#945;-santonin was transformed using a pure strain of Cunninghamella spp. A two-stage standard protocol with growing cells was followed, which led to 8&#946;-hydroxy-&#945;-santonin. The structure of the product was unequivocally elucidated by spectroscopic methods. Both the starting material and metabolite were tested in vitro for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl method, and cytotoxic activity was tested using the Artemia salina (brine shrimp) method. In both assays, the new compound was less active than substrate and reference compounds, which means that the introduction of a hydroxyl group on carbon-8 of (\u2013)-&#945;-santonin with &#946; stereochemistry did not improve the tested biological activities.","palabras_clave":"biotransformation |Cunninghamella spp|8-hydroxysantonin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88864,"idioma_id":4,"titulo":"?Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways.","resumen":"AbstractBisphosphonates (BPs) inhibit osteocyte and osteoblast apoptosis via opening of connexin (Cx) 43 hemichannels and activating the extracellular signal regulated kinases ERKs. Previously, we hypothesized that intracellular survival signaling is initiated by interaction of BPs with Cx43. However, using whole cell binding assays with [3H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17\/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17\/2.8 cells pretreated with agents that disassemble Cx channels. In addition, both BPs and the PTP inhibitor Na3VO4 increased proliferation of cells expressing Cx43 or not. Furthermore, although BPs are internalized and inhibit intracellular enzymes in osteoclasts, whether the drugs penetrate non-resorptive bone cells is not known. To clarify this, we evaluated the osteoblastic uptake of AF-ALN, a fluorescently labeled analog of alendronate. AF-ALN was rapidly internalized in cells expressing Cx43 or not indicating that this process is not mediated via Cx43 hemichannels. Altogether, these findings suggest that although required for triggering intracellular survival signaling by BPs, Cx43 is dispensable for cellular BP binding, its uptake, as well as the proliferative effects of these agents.","palabras_clave":"Bisphosphonates|   Cx43 hemichannels|   AF-ALN uptake|   Osteoblast survival"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88865,"idioma_id":4,"titulo":"Evaluation of Diachasmimorpha longicaudata (Hymenoptera: Braconidae) as a mortality factor of Ceratitis capitata (Diptera: Tephritidae) infesting Citrus species under laboratory and field cage conditions.","resumen":"Ceratitis capitata (or medfly) is one of the major pests currently affecting fruitcrops in northwestern Argentinian Citrus-producing areas. Medfly populationsare sustained in large exotic fruits, such as Citrus paradisi, Citrus aurantium andCitrus sinensis, which are known to hinder the activity of almost all nativeparasitoid species. Therefore, a feasible approach to controlling medfly involvesthe use of exotic parasitoids such as Diachasmimorpha longicaudata. In this study, the prediction that parasitoid females would be proficient at finding medfly larvae infesting the Citrus species mentioned earlier was tested. Particularly, the variation in fruit species preference by parasitoid females, the efficacy of the parasitoid to kill medfly and the effect of host density on parasitoid performance were determined. Parasitoids were allowed to forage for 8 h on grapefruits and oranges artificially infested with medfly larvae under controlled (laboratory) and uncontrolled (field cage) environmental conditions. Fruit choice and no-choice tests were performed. Results were assessed by comparing the number of female visits to and ovipositor insertions into the fruit, and parasitoid emergence, parasitism and additional host mortality percentages. Parasitoid preference for visiting larger fruits (sour orange and grapefruit) may be related to the increased fruit surface area. Ovipositional activity on fruit was influenced by the variation of the larval host density per unit of fruit surface. The higher parasitism rates recorded from sweet orange would be mainly a result of both increased host density and fruit physical features. Nevertheless, D. longicaudata showed the capacity to parasitise hosts in all Citrus species tested.","palabras_clave":"Diachasmimorpha longicaudata|Citrus|Ceratitis capitata; |biological control|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88866,"idioma_id":4,"titulo":"Effect of Exposure Time and Ratio of Hosts to Female Parasitoids on Offspring Production of Diachasmimorpha longicaudata (Hymneoptera: Braconidae) Reared on Anastrepha fraterculus (Diptera: Tephritidae) Larvae","resumen":"Diachasmimorpha longicaudata (Ashmead) is a larval-prepupal endoparasitoid of tephritid fruit .y pests in tropical and subtropical countries. Because citrus-growing areas of northern Argentina are the most affected by Anastrepha fraterculus (Wiedemann), D. longicaudata presents as a potential candidate for augmentative releases against it. Within this context, parasitoid rearing must be focused on offspring yield optimization in order to sustain a successful massrearing process. Hence, the best ratio of A. fraterculus larva to female parasitoids and the best exposure time for achieving the greatest parasitoid yield with the highest proportion of female progeny were determined under laboratory conditions in the present study. The effect of superparasitism on the percentage of D. longicaudata emergence was also assessed. Third-instars of A. fraterculus were exposed for 30, 60, 90, and 120 min to 30 mated, 5-7 d-old parasitoid females at host\/parasitoid ratios of 2:1, 4:1, 6:1, 8:1, and 10:1. Results showed that a low ratio of hosts exposed to parasitoids for a short time was essential to achieve parasitoid emergence rates exceeding 70%, and to achieve a female:male sex ratio of at least 61:39. Increasing both the ratio of host larvae to parasitoid further than 4:1 and the exposure time of D. longicaudata to hosts beyond 30 min did not signi.cantly enhance overall parasitoid progeny yield. There was a significant negative correlation between the number of parasitoid 1st instars recorded per dissected host pupa and the percentage of parasitoid emergence. Conversely, a signi.cant positive correlation was found between superparsitism and additional host mortality. Although a female-biased sex ratio resulted in all treatments, the greater parasitoid female progeny proportions were found in association with the higher levels of superparasitism","palabras_clave":"MOSCAS DE LA FRUTA|PARASITOIDES|PRODUCCION|CONTROL BIOLOGICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88867,"idioma_id":4,"titulo":"Dissolution Studies of Generic Medications:  New Evidence of Deviations from the  Transitivity Principle","resumen":"Current international criteria to guarantee that two equivalent pharmaceutical medications are interchangeable establish that substitution may be done whenever studies indicate that a generic or similar product is bioequivalent to the reference product. The principle of transitivity defines interchangeability between approved pharmaceutical equivalents (i.e., given two generic products B and C and a reference A, if B and C are bioequivalent to A, then B and C are assumed to be bioequivalent although bioequivalence between them has not been actually assessed). In this study, the goal was to test the applicability of the transitivity principle in establishing interchangeability between pharmaceutical equivalents. We obtained the dissolution profiles of all the products corresponding to tablets of ranitidine 300 mg and cephalexin 500 mg (Biopharmaceutics Classification System Class III), furosemide 40 mg (Class IV), and ibuprofen 400 mg and 600 mg (BCS Class II) available in the Argentinean pharmaceutical market. Dissolution profiles of all possible pairs were compared through similarity factor f2. The results obtained bring into question the general validity of the transitivity principle, as many examples were observed to have dissolution profiles similar to the reference product, yet were not equivalent. Although this has only been assessed through in vitro tests, our results are potentially important, as a number of recent reports have suggested the extension of biowaivers to certain BCS Class II and Class III products, including ranitidine hydrochloride and ibuprofen.","palabras_clave":"TRANSITIVITY PRINCIPLE|BIOEQUIVALENCE|DISSOLUTION PROFILES|SIMILARITY FACTOR F2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88868,"idioma_id":4,"titulo":"Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients","resumen":"Background: HBV-X protein is associated with the pathogenesis of HBV related diseases, specially in hepatocellular  carcinomas of chronic patients. Genetic variability of the X gene includes genotypic specific variations and  mutations emerging during chronic infection. Its coding sequence overlaps important regions for virus replication,  including the basal core promoter. Differences in the X gene may have implications in biological functions of the  protein and thus, affect the evolution of the disease. There are controversial results about the consequences of  mutations in this region and their relationship with pathogenesis. The purpose of this work was to describe the  diversity of HBV-X gene in chronic hepatitis patients infected with different genotypes, according to liver disease.  Methods: HBV-X gene was sequenced from chronic hepatitis B patient samples, analyzed by phylogeny and  genotyped. Nucleotide and aminoacid diversity was determined calculating intragenetic distances. Mutations at  127, 130 and 131 aminoacids were considered in relation to liver disease.  Results: The most prevalent genotype detected in this cohort was F (F1 and F4), followed by D and A. Most of the  samples corresponding to genotypes A and F1 were HBeAg(+) and for genotypes D and F4, HBeAg(neg) samples  were represented in a higher percentage. Intragenetic distance values were higher in HBeAg(neg) than in positive  samples for all genotypes, and lower in overlapped regions, compared to single codification ones. Nucleotide and  aminoacid diversities were higher in HBeAg(neg), than in HBeAg(+) samples.  Conclusions: Independently of the infecting genotypes, mutations at any of 127, 130 and\/or 131 aminoacid  positions and HBeAg(neg) status were associated with mild liver disease in this cohort.","palabras_clave":"HEPATITIS B VIRUS|MOLECULAR CHARACTERIZATION|X PROTEIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88869,"idioma_id":4,"titulo":"Molecular Survey of Hepatitis C Virus in the Touristic City of Mar Del Plata, Argentina","resumen":"The global epidemiology of Hepatitis C Virus (HCV) may be roughly   described by two groups of genotypes: the worldwide distributed ones   (subtypes 1a, 1b, 2a and 3a, among others) and the endemic ones   (subtypes 4a, 5a, 6a, among others). Epidemiological and population   dynamic studies of the worldwide distributed genotypes have shown that   subtypes 1a and 3a are common among intravenous drug users (IDUs) and   that they are also in expansion in some countries. The molecular survey   of HCV provides some clues about the epidemiological status of the   infections in a local scale and the phylogenetic and demographic   reconstruction analyses complement this study by inferring whether the   infections of certain subtypes are in a steady state or expanding. Here,   a molecular survey of the HCV variants that circulate in the touristic   city of Mar del Plata (Buenos Aires, Argentina) was performed in samples   obtained from 42 patients. The subtypes detected were 1a (32 patients),   3a (8 patients) and 1b (2 patients). The demographic history of subtype   1a inferred using the sequence data showed an exponential growth in the   1990's. The period of viral expansion was delayed compared with that   observed for the same genotype in other countries where the transmission   was associated with IDUs. Also, the phylogeographic analysis of HCV-1a   showed a statistically significant association between the location of   the samples and the phylogeny, which may be the result of the local   transmission of HCV in the city. The molecular analysis helped in the   description of the complex epidemiological context of a touristic city,   and pointed out that some sanitary measures should be taken in order to   reduce the transmission of HCV (and maybe of HIV) among IDUs.","palabras_clave":"Hepatitis C Virus|Molecular Epidemiology|Phylogeny|Coalescence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88870,"idioma_id":4,"titulo":"Zinc and cadmium biosorption by untreated and Calcium-treated Macrocystis pyrifera in a batch system","resumen":"Zinc and cadmium can be efficiently removed from solutions using the brown algae, Macrocystis pyrifera. Treatment with CaCl2 allowed stabilization of the biosorbent. The maximum biosorption capacities in mono-component systems were 0.91 mmol g-1 and 0.89 mmol g-1 and the Langmuir affinity coefficients were 1.76 L mmol-1 and 1.25 L mmol-1 for Zn(II) and Cd(II), respectively. In two-component systems, Zn(II) and Cd(II) adsorption capacities were reduced by 50 and 40 %, respectively and the biosorbent showed a preference for Cd(II) over Zn(II). HNO3(0.1 M) and EDTA (0.1 M) achieved 90-100 % desorption of both ions from the loaded biomass. While HNO3 preserved the biomass structure, EDTA destroyed it completely. Fourier transform infrared spectra identified the contribution of carboxylic, amine and sulfonate groups on Zn(II) and Cd(II) biosorption. These results showed that biosorption using M. pyrifera- treated biomass could be an affordable and simple process for cadmium and zinc removal from wastewaters.","palabras_clave":"BIOSORPTION|MACROCYSTIS|ZINC|CADMIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88871,"idioma_id":4,"titulo":"First prokaryotic biodiversity assessment using molecular techniques of an acidic river in Neuquén, Argentina","resumen":"  \t  \t    Two  acidic hot springs close to the crater of Copahue Volcano (Neuquén,  Argentina) are the source of the Río Agrio. The river runs several  kilometres before flowing into Caviahue Lake. Along the river,  temperature, iron, other metal, and protons concentrations, decrease  gradually with distance downstream. From the source to the lake and  depending on the season, pH can rise from 1.0 (or even less) to about  4.0 while temperature values decrease from 70°C to 15°C. Water  samples were taken from different stations on the river selected  according to their physicochemical parameters. In order to assess  prokaryotic biodiversity throughout water column, different and  complementary molecular biology techniques were used, mainly in situ  hybridization and 16S rRNA gene cloning and sequencing. All  microorganisms found are typical of acidic environments. Sulphur  oxidizing bacteria like Acidithiobacillus thiooxidans and   Acidithiobacillus. albertensis were detected in every station.  Moderately thermophile iron and sulphur oxidizing bacteria, like  members of Alicyclobacillus and Sulfobacillus genus  were also ubiquitous. Strict iron oxidizing bacteria like  Leptospirillum and Ferrimicrobium were present at the  source of the river, but disappeared downstream where iron  concentrations were much lower. Iron oxidizing, mesophilic  Ferroplasma spp. were the main archaea found. The data  presented in this work represents the first molecular assessment of  this rare natural acidic environment.","palabras_clave":"Rio Agrio|prokaryotic biodiversity|extremophiles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88872,"idioma_id":4,"titulo":"Equilibrium and kinetic study of the biosorption of chromium(III) by two brown algae: Macrocystis pyrifera and Undaria pinnatifida","resumen":"Abstract  Two brown algae, Macrocystis pyrifera and Undaria pinnatifida were employed to  remove Cr(III) from aqueous solutions. Both seaweeds were characterized in terms of  alginate yields. The alginate contents were 20% and 30% of the dry weight for M.  pyrifera and U. pinnatifida, respectively. Kinetics experiments were carried out at  different initial pH values. Cr(III) biosorption was affected by the solution pH. The  highest metal uptake was found at pH 4.0 for both biosorbents. Different models were  applied to elucidate the rate?controlling mechanism: pseudo first order, pseudo second  order, external mass transfer and intra- particle diffusion. The application of Langmuir,  Freundlich and Dubinin?Radushkevich models to the equilibrium data showed a better  fitting to the first model. The maximum Cr(III) sorption capacity and the affinity  coefficient were very similar for both biosorbents: qm=0.77 mmol.g-1 and b= 1.20  L.mmol-1 for M. pyrifera and 0.74 mmol.g-1 and 1.06 L.mmol-1 for U. pinnatifida. The  free energy of the sorption process was estimated using the Dubinin?Radushkevich  isotherm. The values found indicate that the processes are chemical sorptions. To  evaluate the significance of the ion exchange mechanism, the light metals (Ca2+, Na+,  Mg2+ and K+) and pH were measured during the experiments.","palabras_clave":"ADSORPTION|BROWN ALGAE|CHROMIUM|EQUILIBRIUM|KINETICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88873,"idioma_id":4,"titulo":"Corrosion of Conductor Rolls in an Electrogalvanizing Line","resumen":"Conductor rolls in continuous cold rolled steel strip horizontal acid electrogalvanizing lines after some period of service  suffer a surface deterioration that alters its color, aspect and eventually its roughness what is more deleterious to its good  performance. The surface degradation finally produce a pattern on the roll surface that is transferred or copied to the  electrogalvanized strip surface originating quality defects that could make some level of rejections in high quality  products. This process has been historically thought as an erosion-corrosion one. This work shows some interesting results  that help in the understanding of the nature of this specific corrosion mechanism. It is also presented a new method  capable of evaluate the corrosion resistance of new materials for construction of conductor rolls for this type of industrial  process. Finally a comparison of the corrosion resistance of different alloys using this technique was made.","palabras_clave":"RODILLOS CONDUCTORES|CORROSION|ELECTROGALVANIZADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88874,"idioma_id":4,"titulo":"Detection of low quantum yield fluorophores and improved imaging times using metallic nanoparticles","resumen":"The behavior of a fluorophore near a gold nanoparticle is rationalized by a theoretical description of the parameters that modify the fluorescence emission: nanoparticle\u2013fluorophore distance, fluorescence quantum yield (0), and fluorophore absorption and emission spectra, to find optimum conditions for designing fluorophore\u2013nanoparticle probes. The theoretical maximum gain in brightness of the nanoparticle\u2013fluorophore system with respect to the isolated molecule increases almost inversely proportional to 0. The brightness enhancement in imaging experiments in vitro was assessed by using Au-SiO2 core\u2013shell nanoparticles deposited on glass. A 13-fold emission brightness enhancement for weakly fluorescent molecules was observed. A significant increase in fluorophore photostability, rendering longer imaging times, was obtained for fluorophores interacting with gold nanoparticles incorporated by endocytosis in cells. Our results illustrate a way to increase imaging times and to study molecules in the vicinity of a metallic nanoparticle after photobleaching of background fluorescence.","palabras_clave":"fluorescence enhancement|gold nanoparticles|fluorescence imaging|photobleaching microscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88875,"idioma_id":4,"titulo":"Bis (Trifluoromethyl) Sulfone, CF3SO2CF3:  Synthesis, Vibrational and Conformational properties","resumen":"Bis (trifluoromethyl) sulfone, CF3SO2CF3, was obtained as a byproduct in the synthesis of CF3SO2SCF3. The compound was characterized by infrared and Raman spectroscopy as well quantum chemical calculations. Quantum mechanical calculations indicate the possible existence of two conformers symmetrically equivalent with C2 symmetry. The preference for the staggered form was studied using the total energy scheme and the natural bond orbital (NBO) partition scheme. Additionally, the total potential energy was deconvoluted using a sixfold decomposition in terms of a Fourier-type expansion, showing that the hyperconjugative effect was dominant in stabilizing the staggered conformer. Infrared and Raman spectra of CF3SO2CF3 were obtained. Harmonic vibrational wavenumbers and a scaled force field were calculated, leading to a final root mean-square deviation of 7.8 cm_1 when comparing experimental and calculated wavenumbers.","palabras_clave":"Infrarrojo|Raman|DFT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88876,"idioma_id":4,"titulo":"Interaction of S-methyl methanethiosulfonate with DPPC bilayer","resumen":"The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS)interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS withdipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipideffect on vesicle stability was studied. The results show that MMTS interacts to different extents withthe phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states.To gain a deeper insight into MMTS properties that may be potentially helpful in the design of newdrugs with therapeutic effects, we performed theoretical studies that may be the basis for the designof their mode of action.","palabras_clave":"MMTS|DPPC|bilayers|DFT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88877,"idioma_id":4,"titulo":"Preparation and Characterization of Plasticized Gelatin Films Cross-Linked With Low Concentrations of Glutaraldehyde","resumen":"Thermal and mechanical properties as well as  moisture resistance and water vapor barrier properties of  films from bovine gelatin added with D-sorbitol (30 wt%) as  plasticizer and cross-linked with low amounts of glutaraldehyde  (GTA, from 0 to 2 wt%) were investigated to  determine their suitability as barrier layers for flexible  packaging materials. Results revealed that free amino side  chain groups of gelatin decreased with GTA, confirming the  occurrence of cross-linking between GTA and gelatin. The  extent of cross-linking reaction in the presence of D-sorbitol  was lower compared with the unplasticized counterpart  suggesting that plasticizer hampers GTA to react. The glass  transition temperature (Tg) as measured from differential  scanning calorimetry (DSC) increased with GTA concentration  owing to the formation of more reticulated materials  while the incorporation of D-sorbitol led to a small reduction  in this parameter due to plasticization. Increasing GTA  concentration from 0 to 1 wt% provoked the enhancement of  elastic modulus from 3.7 ± 0.2 to 4.9 ± 0.2 GPa. These  values reduced significantly by the addition of D-sorbitol,  whereas elongation at break improved in about 150%. The  optimum formulation for the intended purpose was that  containing 1 wt% GTA and 30 wt% D-sorbitol since it  exhibited the best set of properties: total soluble mater  reduced from 100 to 16%, moisture absorption decreased  from 1854.1 ± 85 to 210.4 ± 8%, water vapor permeability  at 65% relative humidity improved from 2.42 ± 0.27  to 0.94 ± 0.06 9 10-14 kg m Pa-1 s-1 m-2, with minor  reduction in opacity and with the additional benefit of  releasing only 5% of the initial GTA content.","palabras_clave":"GELATIN|GLUTARALDEHYDE|FILM|CROSS LINKING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88878,"idioma_id":4,"titulo":"Bonding Quality of Chemically Modified Soybean Protein Concentrate  Based Adhesives in Particleboards from Rice Husks","resumen":"The aim of the present study was to upgrade the  bonding quality and water resistance of medium-density  particleboards based on rice husks (RH) as a wood substitute  and soybean protein concentrate (SPC) as the binder  via chemical modification of SPC. Alkali (A), citric acid  (CA) and boric acid (BA) were used to modify proteins and  the carbohydrate complex in SPC. The effect of chemical  treatment performed on SPC was followed by Fourier  transform infrared, differential scanning calorimetry,  thermo-gravimetric analysis and initial apparent viscosity  measurements. Board properties were evaluated in terms of  internal bond (IB) and physical properties. Results revealed  that boards bonded with SPC treated with boric acid,  exhibited the highest IB and the lowest water absorption  and thickness swelling at 2 and 24 h, due to cross-linking  reactions with exposed OH-groups in the amorphous region  of cellulose of RH. Results demonstrate that boric acidmodified\u2013  SPC-bonded boards met the requirements of IB  recommended by the US Standard ANSI A208.1-2009 for  M1, MS, M2 and M3-grade medium-density particleboards  but failed to pass the thickness swelling required. This  issue of BSPC-RH boards is compensated for by the benefit  of being formaldehyde-free which makes them suitable for  indoor applications.","palabras_clave":"SOYBEAN PROTEIN CONCENTRATE|RICE HUSK|PARTICLEBOARD|CHEMICAL MODIFICATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88879,"idioma_id":4,"titulo":"Differential effect of short-term cold stress on growth, anatomy, and hormone levels in cold-sensitive versus -resistant cultivars of Digitaria eriantha","resumen":"Two cultivars of Digitaria eriantha (cold-sensitive cv. Sudafricana and cold-resistant cv. Mejorada INTA) were exposed to cold stress (5 C) for 0, 6, 24, or 72 h, and compared in terms of leaf and root growth, recovery period, shoot and leaf anatomy, and levels of chlorophyll, auxin (indole-3-acetic acid, IAA) and cytokinins (CKs). In Sudafricana, cold treatment caused reduced growth, slight changes in chlorophyll level, reduced levels of IAA and CK iso-pentenyladenine (iP), and reduced leaf dry weight (DW) and fresh weight (FW) during the recovery period. Anatomical damage was observed in chloroplasts, main stem, and axillary buds. Ultrastructural study showed reduced numbers of starch grains in chloroplasts of the bundle sheath and mesophyll. In Mejorada, cold treatment had no significant effect on growth or chlorophyll level. Leaf DW and FW quickly returned to normal levels during the recovery period. Anatomy of ground meristem was affected, but ultrastructure of bundle sheath and mesophyll chloroplasts was not. The cold tolerance of cv. Mejorada appears to be related to the stability of chlorophyll and CK levels, increase of IAA, and maintenance of normal shoot and leaf anatomy and ultrastructure.","palabras_clave":"COLD STRESS|DIGITARIA ERIANTHA|AUXIN|CYTOKININ|GROWTH PARAMETERS|ANATOMY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88880,"idioma_id":4,"titulo":"Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone","resumen":"The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg\/Kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100-120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10 % w\/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production.","palabras_clave":"Experimental Metabolic Syndrome|Adipokines|Insulin Sensitivity|Sex Steroid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88881,"idioma_id":4,"titulo":"Search for a heavy neutral particle decaying into an electron and a muon using 1 fb&#8722;1 of ATLAS data","resumen":"A search is presented for a high mass neutral particle that decays directly to the e±&#956;&#8723; final  state. The data sample was recorded by the ATLAS detector in ps = 7 TeV pp collisions at the LHC from  March to June 2011 and corresponds to an integrated luminosity of 1.07 fb&#8722;1. The data are found to be  consistent with the Standard Model background. The high e±&#956;&#8723; mass region is used to set 95% confidence  level upper limits on the production of two possible new physics processes: tau sneutrinos in an R-parity  violating supersymmetric model and Z&#8242;-like vector bosons in a lepton flavor violating model.","palabras_clave":"HIGH ENERGY PHYSICS|ATLAS, CERN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88882,"idioma_id":4,"titulo":"Measurement of the jet fragmentation function and transverse profile in proton-proton collisions at a center-of-mass energy of 7 TeV with the ATLAS detector.","resumen":"The jet fragmentation function and transverse profile for jets with 25&nbsp;GeV&lt;p            T&#8201;jet&lt;500&nbsp;GeV and |&#951;            jet|&lt;1.2 produced in proton?proton collisions with a center-of-mass energy of 7&nbsp;TeV are presented. The measurement is performed            using data with an integrated luminosity of 36 pb&#8722;1.Jets are reconstructed and their momentum measured using calorimetricinformation. The momenta of the charged particle constituents aremeasured using the tracking system. The distributions corrected fordetector effects are compared with various Monte Carlo event generatorsand generator tunes. Several of these choices show good agreement withthe measured fragmentation function. None of these choices reproduceboth the transverse profile and fragmentation function over the fullkinematic range of the measurement.","palabras_clave":"JET|FRAGMENTATION|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88883,"idioma_id":4,"titulo":"A search for ttbar resonances with the ATLAS detector in 2.05 fb^-1 of proton-proton collisions at sqrt(s) = 7 TeV.","resumen":"A search for top quark pair resonances in final states containing at least one electron or muon has been performed with the ATLAS experiment at the CERN Large Hadron Collider. The search uses a data sample corresponding to an integrated luminosity of 2.05 fb^-1, which was recorded in 2011 at a proton-proton centre-of-mass energy of 7 TeV. No evidence for a resonance is found and limits are set on the production cross-section times branching ratio to ttbar for narrow and wide resonances. For narrow Z´ bosons, the observed 95% credibility level limits range from 9.3 pb to 0.95 pb for masses in the range of m_Z´ = 500 GeV to m_Z´ = 1300 GeV. The corresponding excluded mass region for a leptophobic topcolour Z´ boson (Kaluza-Klein gluon excitation in the Randall-Sundrum model) is m_Z´ < 880 GeV (m_{g_KK} < 1130 GeV).","palabras_clave":"HIGH ENERGY PHYSICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88884,"idioma_id":4,"titulo":"Search for lepton flavour violation in the e&#956; continuum with the ATLAS detector in &#8730; s = 7 TeV pp collisions at the LHC","resumen":"This paper presents a search for the t-channel exchange of an R-parity violating scalar top quark (˜t) in the e ± &#956; &#8723; continuum using 2.1 fb&#8722;1 of data collected by the ATLAS detector in &#8730; s = 7 TeV pp collisions at the Large Hadron Collider. Data are found to be consistent with the expectation from the Standard Model backgrounds. Limits on R-parity-violating couplings at 95 % C.L. are calculated as a function of the scalar top mass (m˜t ). The upper limits on the production cross section for pp&#8594;e&#956;X, through the t-channel exchange of a scalar top quark, ranges from 170 fb for m˜t = 95 GeV to 30 fb for m˜t = 1000 GeV.","palabras_clave":"ALTAS ENERGIAS|SUSY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88885,"idioma_id":4,"titulo":"Measurement of the top quark mass with the template method in the t ¯ t &#8594;lepton+jets channel using ATLAS data","resumen":"The top quark mass has been measured using the template method in the tt&#713;&#8594;lepton+jets channel based on data recorded in 2011 with the ATLAS detector at the LHC. The data were taken at a proton-proton centre-of-mass energy of &#8730;s=7 TeV and correspond to an integrated luminosity of 1.04 fb&#8722;1. The analyses in the e+jets and &#956;+jets decay channels yield consistent results. The top quark mass is measured to be m top=174.5±0.6stat±2.3syst GeV.","palabras_clave":"Top quark|Mass|ATLAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88886,"idioma_id":4,"titulo":"A study of the material in the ATLAS inner detector using secondary hadronic interactions","resumen":"The ATLAS inner detector is used to reconstruct secondary vertices due to hadronic interactions of primary collision products, so probing the location and amount of material in the inner region of ATLAS. Data collected in 7 TeV pp collisions at the LHC, with a minimum bias trigger, are used for comparisons with simulated events. The reconstructed secondary vertices have spatial resolutions ranging from ~200 microns to 1 mm. The overall material description in the simulation is validated to within an experimental uncertainty of about 7%. This will lead to a better understanding of the reconstruction of various objects such as tracks, leptons, jets, and missing transverse momentum.","palabras_clave":"ATLAS|LHC|ALTAS|ENERGIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88887,"idioma_id":4,"titulo":"New natural variants of hepatitis B virus among Amerindians from Argentina with mainly occult infections","resumen":"BACKGROUND:Hepatitis B virus infection is frequent among Amerindians. In Argentina HBV genotypes A, B, C, D, E, F and H were described in different populations, while some cases of occult hepatitis B infection (OBI) were reported in human immunodeficiency virus (HIV) coinfected patients.OBJECTIVE:To determine the prevalence, genetic diversity of HBV and to analyze the deduced amino acid sequence of both S and viral polymerase (P) genes among Amerindians of Argentina.STUDY DESIGN:A cross-sectional study including 561 individuals belonging to distinct ethnic groups, the Mbyá-guaraní (MG), the Kolla (K), the Sagua-Huarpe (SH) and the Wichi (W) was performed.RESULTS:The prevalence of HBsAg was 1.7% and 1.4% for the MG and SH, respectively, while anti-HBc was detected in all communities. HBV DNA of S\/P and preCore-Core genomic regions were amplified by nested polymerase chain reaction in 59 reactive samples for anti-HBc total Ig and\/or HBsAg. Of them, thirteen exhibited detectable HBV DNA, eleven of which were identified as OBI. Genotype F was predominant in the MG community with co-circulation of subgenotypes F4, F1b, A2 and D3, while subgenotype C2 prevailed within the SH community. All cases exhibited the polymorphism rtL217R within the RT domain associated to resistance to adefovir. Mutations rtD206E and rtV207I associated with lamivudine resistance were found in two MG and three SH respectively. Other new substitutions were described within the P sequence.CONCLUSIONS:This study shows for the first time the predominance of OBI, HBV subgenotypes and natural variants in Amerindians from Argentina.","palabras_clave":"HBV|HEPATITIS|NATIVES|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88888,"idioma_id":4,"titulo":"Hydrochloroethers in the troposphere: Kinetics with Cl atoms, lifetimes and atmospheric acceptability indices","resumen":"Rate constants for the gas-phase reactions of chlorine atoms with 2-chloroethyl ethyl ether (k1) andbis(2-chloroethyl) ether (k2) were determined for the &#64257;rst time using a conventional relative ratetechnique. Experiments were carried out at (298  2) K and atmospheric pressure using synthetic airas bath gas. The decay rates of the hydrochloroethers were measured relative to those of n-pentaneand n-heptane. The following rate constants were derived in units of cm3molecule1s1:k1 ¼ (1.7  0.5)  1010and k2 ¼ (1.0  0.3)  1010. The rate constants obtained are compared withprevious literature data to indicate reactivity trends and are used to estimate the global atmosphericlifetimes (sglobal) of the studied hydrochloroethers. Radiative forcing ef&#64257;ciencies (RE) of the ethers weredetermined from their integrated IR absorption cross-sections. Using sglobal and RE, estimations weremade of atmospheric hazard indices of the two chlorinated ethers such as the ozone depletion potential(ODP) and the global warming potential (GWP).","palabras_clave":"hidrocloroeteres|cinetica|atomos de cloro"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88889,"idioma_id":5,"titulo":"CULTIVOS AGRICOLAS Y SU ROL COMO RESERVORIOS DE CARBONO Y FUENTES DE ENERGÍA","resumen":"El objetivo del presente trabajo fue analizar el potencial de la biomasa residual agrícola generada desde las principales producciones del municipio de Coronel Moldes, provincia de Salta (ají, tabaco Criollo y tabaco Virginia) en cuanto a la mitigación de GEI responsables del sobrecalentamiento de la atmósfera. Se consideraron dos estrategias generales de mitigación: i) como reservorio de carbono (C) y ii) como fuente de energía renovable neutra en emisiones de C, que sustituiría parcialmente a los combustibles fósiles empleados. Se evaluó este potencial en relación con otras fuentes de biomasa para las cuales existían estudios previos en la zona. Si bien su aporte como reservorio de C no es permanente, permite dimensionar su contribución en relación a la biomasa natural de la zona. En cuanto fuente de energía, el empleo de esta biomasa posibilitaría evitar cerca de 500 tCO2\/año (emisiones anuales de 90 ciudadanos) con beneficios económicos y ambientales.2\/año (emisiones anuales de 90 ciudadanos) con beneficios económicos y ambientales.","palabras_clave":"BIOENERGIA|CAMBIO CLIMATICO|CORONEL MOLDES|CULTIVOS AGRICOLAS|MITIGACION DE GEI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88890,"idioma_id":4,"titulo":"Estimating aboveground biomass in native forests using remote sensing data combined with spectral radiometry in Salta, Argentina","resumen":"The management of forests as carbon (C) reservoirs could be a valid strategy for mitigating global climate change. In Salta, Argentina, there is an urgent need for updated information on biomass stocks in order to assess the C sequestering and release made &#8203;&#8203;by native forests. We studied three ecosystems (Chaco, Yungas and shrubland) by combining different data: a) field-estimated above-ground biomass (AGB); b) field-spectral data and c) spectral data from remote sensing. AGB was estimated through allometric equations. Radiometric measurements were synthesized into a set of spectral vegetation indices (VI). The satellite data was calibrated with those obtained through field radiometry, allowing us to find a predictive AGB model which indicates an AGB average of 85 ± 250 t.ha-1 for the center of the province of Salta. The model which was finally selected increases the level of estimate detail made &#8203;&#8203;at the national level and will allow the monitoring of such data. ","palabras_clave":"ABOVE-GROUND BIOMASS|CARBON STOCK|FIELD RADIOMETRY|FOREST MANAGEMENT|GIS|REMOTE SENSING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88891,"idioma_id":4,"titulo":"Boron delivery with liposomes for Boron Neutron Capture Therapy (BNCT): Biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential","resumen":"Boron neutron capture therapy (BNCT) combinesselective accumulation of 10B carriers in tumor tissuewith subsequent neutron irradiation. We previously demonstratedthe therapeutic efficacy of BNCT in the hamstercheek pouch oral cancer model. Optimization of BNCTdepends largely on improving boron targeting to tumor cells.Seeking to maximize the potential ofBNCT for the treatmentfor head and neck cancer, the aim of the present study was toperform boron biodistribution studies in the oral cancermodel employing two different liposome formulations thatwere previously tested for a different pathology, i.e., inexperimentalmammary carcinoma in BALB\/c mice: (1)MAC:liposomes incorporating K[nido-7-CH3(CH2)15-7,8-C2B9H11] in the bilayer membrane and encapsulating a hypertonicbuffer, administered intravenously at 6 mg B per kg bodyweight, and (2) MAC-TAC: liposomes incorporatingK[nido-7-CH3(CH2)15-7,8-C2B9H11] in the bilayer membraneand encapsulating a concentrated aqueous solution ofthe hydrophilic species Na3 [ae-B20H17NH3], administeredintravenously at 18 mg B per kg body weight. Samples oftumor, precancerous and normal pouch tissue, spleen, liver,kidney, and blood were taken at different times postadministrationand processed to measure boron content byinductively coupled plasma mass spectrometry. No ostensibleclinical toxic effects were observed with the selectedformulations. Both MAC and MAC-TAC delivered boronselectively to tumor tissue. Absolute tumor values forMAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to43.9 ± 17.6 ppm at 54 hwith very favorable ratios of tumorboron relative to precancerous and normal tissue, makingthese protocols particularly worthy of radiobiologicalassessment. Boron concentration values obtained wouldresult in therapeutic BNCT doses in tumor without exceedingradiotolerance in precancerous\/normal tissue at thethermal neutron facility at RA-3.","palabras_clave":"BNCT|BORON NEUTRON CAPTURE THERAPY|LIPOSOMES|BIODISTRIBUTION|EXPERIMENTAL ORAL CANCER|BORON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88892,"idioma_id":4,"titulo":"Transient Features of quantum open maps","resumen":"We study families of open chaotic maps that classically share the sameasymptotic properties -- forward and backwards trapped sets, repellerdimensions, escape rate -- but differ in their short time behavior. When thesemaps are quantized we find that the fine details of the distribution ofresonances and the corresponding eigenfunctions are sensitive to the initialshape and size of the openings. We study phase space localization of theresonances with respect to the repeller and find strong delocalization effectswhen the area of the openings is smaller than $\\hbar$.","palabras_clave":"quantum chaos: semiclassical methods|semiclassical theories and applications"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88893,"idioma_id":4,"titulo":"Ethanol consumption enhances periodontal inflammatory markers in rats","resumen":"      Objective: The aim of this study was to assess the short term effect of ethanol administration on periodontal disease in rats. Design: Rats received either ethanol 2 g\/kg or water by gastric gavage twice a day. On the fifth day ligatures were tied around the molars of half of the rats to induce periodontitis. After 7 days gingival tissue was removed and assayed for inflammatory markers. Finally, hemi-mandibles were extracted to evaluate bone loss by histomorphometrical techniques. Results: The experimental periodontitis increased significantly the mRNA expression ( p &lt; 0.001) and activity ( p &lt; 0.001) of inducible nitric oxide synthase (iNOS) in the gingival tissue, whilst short time ethanol administration increased iNOS activity ( p &lt; 0.05) and produced an additive effect on iNOS mRNA expression augmented by periodontitis ( p &lt; 0.01). The short time ethanol administration also potentiated the periodontitis stimu-latory effect on the mRNA expression of interleukin (IL)-1b ( p &lt; 0.01 and p &lt; 0.001, in semi-quantitative and real time PCR, respectively) and on the height of periodontal ligament ( p &lt; 0.05). However, the ligature-induced periodontitis, but not ethanol administration, increased the prostaglandin E2 content ( p &lt; 0.05) and, diminished the alveolar bone volume ( p &lt; 0.05), as compared to sham rats. Conclusion: The present results suggest that ethanol consumption could represent a risk indicator for periodontal disease since augments the expression of inflammatory markers, in healthy rats, and increases them, at short term, during the illness. However, scale longitudinal investigation and more case?control studies are needed to confirm this state-ment. The aim of this study was to assess the short term effect of ethanol administration on periodontal disease in rats. Design: Rats received either ethanol 2 g\/kg or water by gastric gavage twice a day. On the fifth day ligatures were tied around the molars of half of the rats to induce periodontitis. After 7 days gingival tissue was removed and assayed for inflammatory markers. Finally, hemi-mandibles were extracted to evaluate bone loss by histomorphometrical techniques. Results: The experimental periodontitis increased significantly the mRNA expression ( p &lt; 0.001) and activity ( p &lt; 0.001) of inducible nitric oxide synthase (iNOS) in the gingival tissue, whilst short time ethanol administration increased iNOS activity ( p &lt; 0.05) and produced an additive effect on iNOS mRNA expression augmented by periodontitis ( p &lt; 0.01). The short time ethanol administration also potentiated the periodontitis stimu-latory effect on the mRNA expression of interleukin (IL)-1b ( p &lt; 0.01 and p &lt; 0.001, in semi-quantitative and real time PCR, respectively) and on the height of periodontal ligament ( p &lt; 0.05). However, the ligature-induced periodontitis, but not ethanol administration, increased the prostaglandin E2 content ( p &lt; 0.05) and, diminished the alveolar bone volume ( p &lt; 0.05), as compared to sham rats. Conclusion: The present results suggest that ethanol consumption could represent a risk indicator for periodontal disease since augments the expression of inflammatory markers, in healthy rats, and increases them, at short term, during the illness. However, scale longitudinal investigation and more case?control studies are needed to confirm this state-ment. ","palabras_clave":"Experimental periodontitis|Prostaglandin E|Interleukin 1b|Nitric oxide|Bone loss"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88894,"idioma_id":4,"titulo":"The antorbital fenestra of Metriorhynchidae (Crocodyliformes, Thalattosuchia): Testing its homology within a phylogenetic framework","resumen":"Metriorhynchidae is a clade of extinct marine crocodyliforms of pelagic habits that is nested within the more inclusive group Thalattosuchia that also includes a diversity of fossil taxa found in shallow marine environments (Young et al., 2009). Metri- orhynchids are of particular interest given that they represent the only group of archosaurs completely adapted to marine environ- ments (Ferna &#769;ndez and Gasparini, 2008). Most of the members of this clade are characterized by their delicate and elongated snouts, homodont dentition, paddle-like forelimbs, and hypocer- cal tail, a set of characters that are thought to be marine adapta- tions. Among the unique traits present in metriorhynchids is an opening located anteriorly to the orbit (Ferna &#769; ndez and Gasparini, 2000; Gandola et al., 2006; Ferna &#769;ndez and Herrera, 2009), which has been up to now interpreted as homologous to the antorbital fenestra of other archosaurs.","palabras_clave":"Crocodyliformes|Homology|Phylogeny|Metriorhynchidae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88895,"idioma_id":5,"titulo":"Variación ontogenetica en la histología ósea de Caypullisaurus bonapartei Fernández, 1997 (Ichthyosauria:   Ophthalmosauridae)","resumen":"Con el objetivo de explorar las posibles modificaciones osteohistológicas atribuibles a variaciones ontogenéticas en ictiosaurios, se estudió la microestructura ósea del oftalmosáurido Caypullisaurus bonapartei Fernandez. Se seleccionaron y analizaron secciones delgadas obtenidas a partir de costillas de tres ejemplares (MLP85-I-15-1, 83-XI-15-1 y 83-XI-16-1) exhumados de la Formación Vaca Muerta (Titoniano, Jurásico Tardío) en la Cuenca Neuquina (Argentina). El estado madurativo de estos ejemplares había sido determinado previamente con base en la morfología del húmero y de los anillos escleróticos. Las secciones correspondientes al primer ejemplar se componen por un tejido esponjoso que se distribuye uniformemente alrededor de la cavidad medular. Microscópicamente, el hueso esponjoso es de origen secundario con abundantes espacios internos delimitados por trabéculas óseas donde se observan numerosas generaciones de tejido lamelar superpuestas entre sí. En el segundo ejemplar (juvenil) se observa un tejido esponjoso de origen primario rodeando la cavidad medular y se observan fibras de Sharpey. En el tercer ejemplar, la cavidad medular se encuentra ocupada por un tejido esponjoso secundario que se distribuye uniformemente en toda la sección. Estos resultados sugieren que las modificaciones macroscópicas clásicamente atribuibles a la ontogenia tienen un correlato en la microestructura ósea. Así, en los huesos de individuos inmaduros se observa la presencia de tejido primario,en tanto que los huesos de los individuos maduros están caracterizados por la presencia de tejido remodelado. Estas características son claramente identificables y brindan un criterio auxiliar para la determinación de estadios ontogenéticos cuando no se cuenta con material completo.","palabras_clave":"Histología|Ictiosaurios|Cuenca Neuquina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88896,"idioma_id":4,"titulo":"Acute Exposure to Low-Dose Radiation Disrupts Reproduction and Shortens Survival of Wasmannia auropunctata (Hymenoptera: Formicidae) Queens","resumen":"Irradiation is a postharvest quarantine treatment option to control ants and other hitchhiker pests on fresh horticultural products exported from Hawaii. The radiotolerance of the invasive little Þre ant, Wasmannia auropunctata (Roger) (Hymenoptera: Formicidae: Myrmicinae), was studied to determine a dose sufÞcient for its control. Queens from each of five laboratory microcolonies started from Þve geographic locations in Argentina were irradiated at 20, 50, 70, or 100Gy or left untreated as controls and then followed for 13 wk to observe colony growth. In general, queen survivorship, and the number of eggs, larvae, and pupae observed in the microcolonies decreased with increasing irradiation dose. In the 50-, 70-, and 100-Gy treatments, the number of eggs observed was reduced by 68, 66, and 76%, respectively, compared with untreated control microcolonies. The number of larvae in the 50-, 70-, and, 100-Gy treatments was reduced by 99.6%, and only one pupa was observed in the 50-Gy treatment and none in the 70- and 100-Gy treatments during the 13-wk experiment. Queens in the 100-Gy treatment had signiÞcantly reduced longevity compared with queens in the other treatments. Radiation doses 70 Gy stopped reproduction in W. auropunctata queens and should be sufÞcient as a phytosanitary treatment. Information from additional invasive ants in Myrmicinae and other subfamilies is needed before recommending a generic irradiation treatment for ants.","palabras_clave":"LITTLE FIRE ANT|QUARANTINE PEST|IRRADIATION|PHYTOSANITARY TREATMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88897,"idioma_id":4,"titulo":"Photonic simulation method applied to the study of structural color in Myxomycetes","resumen":"We present a novel simulation method to investigate the multicolored effect of the Diachea leucopoda (Physarales order, Myxomycetes class), which is a microorganism that has a characteristic pointillistic iridescent appearance. It was shown that this appearance is of structural origin, and is produced within the peridium -protective layer that encloses the mass of spores-, which is basically a corrugated sheet of a transparent material. The main characteristics of the observed color were explained in terms of interference effects using a simple model of homogeneous planar slab. In this paper we apply a novel simulation method to investigate the electromagnetic response of such structure in more detail, i.e., taking into account the inhomogeneities of the biological material within the peridium and its curvature. We show that both features, which could not be considered within thesimplified model, affect the observed color. The proposed method is of great potential for the study of biological structures, which present a high degree of complexity in the geometrical shapes as well as in the materials involved.","palabras_clave":"STRUCTURAL COLOR|NATURAL PHOTONIC STRUCTURES|ELECTROMAGNETIC SIMULATION METHODS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88898,"idioma_id":4,"titulo":"Protein restriction during early life in rats alters pancreatic GABAa receptor subunit expression and glucagon secretion in adulthood","resumen":"Objective: Gamma-aminobutyric acid (GABA) is present in the endocrine pancreas and contributes toinsulin and glucagon secretion. Protein restriction during pregnancy and lactation causes impairedglucose homeostasis in adulthood. We investigated the effect of low protein (LP) diet on the GABAergicsystem within islets and associated changes in hormone release.Methods: Wistar rats were fed control (C) or LP diet throughout gestation and lactation; all offspringreceived C diet from weaning (day 21). GABAA receptor presence in islets was examined byWestern blot,and mRNA expression for glutamic acid decarboxylase (GAD) 65 and GABAA and GABAB receptor isoformsby real-time polymerase chain reaction at 130 days. Insulin and glucagon secretion were measuredin vivo after L-arginine stimulation.Results: L-glutamate, the precursor of GABA, was reduced in pancreas from offspring of LP-fed rats atbirth. At day 21, animals receiving LP diet had an elevated GABAA presence within islets, lower fastingplasma insulin, and decreased islet insulin and glucagon content. By day 130, GABAA protein did notdiffer with diet, but the expression of GABAAb3 subunit mRNA was decreased in the LP group. Glucagonsecretion and gene expression were increased in LP-fed rats. Expression of GABAB and GAD within isletswas unaltered.Conclusions: LP diet caused changes to GABAA receptor expression within islets with implications forglucagon secretion and glucose homeostasis","palabras_clave":"islet|GABA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88899,"idioma_id":4,"titulo":"Magnetic reorientation and thermal stability in MnAs\/GaAs (100) micro patterns driven by size effects","resumen":"Size effects and their consequences in the thermal stability of the magnetization of the micro-sizedMnAs\/GaAs(100) ribbons were studied by magnetic force microscopy. We found out that theorientation in which size is reduced plays a key role in the magnetic configuration and thermalstability of the micro-sized patterns. On the one hand, when reducing the size in the [0001]a-MnAs direction, the system shows an improvement in the thermal stability of the remanentmagnetization. On the other hand, when the size is reduced in the [11-20] a-MnAs direction, thesystem goes through a magnetic reconfiguration from in-plane magnetized to out-of-planemagnetized, which also improves the thermal stability.","palabras_clave":"MAGNETIC FORCE MICROSCOPY|MANGANESE COMPOUNDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88900,"idioma_id":4,"titulo":"Structural and electrical characterization of ultra thin SrTiO3 tunnel barriers grown over YBa2Cu3O7 electrodes for the development of high Tc Josephson junctions","resumen":"The transport properties of ultra-thin SrTiO3 (STO) layers grown over YBa2Cu3O7 electrodes were studied by conductive atomic force microscopy at the nano-scale. A very good control of the barrier thickness was achieved during the deposition process. A phenomenological approach was used to obtain critical parameters regarding the structural and electrical properties of the system. The STO layers present an energy barrier of 0.9 eV and an attenuation length of 0.23 nm, indicating very good insulating properties for the development of high-quality Josephson junctions.","palabras_clave":"Insulators|Thin film structure and morphology|Josephson devices|Atomic Force microscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88901,"idioma_id":5,"titulo":"NAMING HYBRIDS IN THE ANDROPOGON LATERALIS COMPLEX (ANDROPOGONEAE, POACEAE) AFTER MULTIVARIATE ANALYSIS","resumen":"The Andropogon lateralis complex is constituted by 13 taxonomic entities: seven species and six class inter-specific hybrids distributed in Central and South America. Natural hybrids within this group are quite common due to lack of inter-specific barriers. These hybrids have been collected in the last two centuries and, in most cases, have caught the attention of taxonomists, who formally described several as new taxa. Therefore, taxonomic entities based on them have been validly published. In southern South America, among the ten taxonomic entities in the A. lateralis complex, five are natural hybrids and at least three possess legitimate names (A. x coloratus, A. x lindmanii, and A. x subtilior).Based on morphometric analyses and previous studies we propose that other two natural hybrids deserve taxonomic names. These entities are Andropogon x velutinus (A. bicornis X A. glaziovii,= Andropogon sp 1 according to Zanin, 2001) and Andropogon x catarinensis (A. bicornis X A. arenarius). Taxonomic treatments of A. x velutinus and A. x catarinensis are presented.","palabras_clave":"Andropogoneae|inter-specific hybrids|morphometry|taxonomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88902,"idioma_id":4,"titulo":"Colonisation of native Andean grasses by arbuscular mycorrhizal fungi  in Puna: a matter of altitude, host photosynthetic pathway and host life  cycles","resumen":"The relationships of altitude, host life cycle (annual or perennial) and photosynthetic pathway (C3 or C4) with arbuscular mycorrhiza (AM) root colonization were analysed in 35 species of Andean grasses. The study area is located in north-western Argentina along altitudinal sites within the Puna biogeographical region. Twenty-one sites from 3320 to 4314 m were sampled. Thirty-five grasses were collected, and the AM root colonization was quantified. We used multivariate analyses to test emerging patterns in these species by considering the plant traits and variables of AM colonization. Pearson's correlations were carried out to evaluate the specific relationships between some variables. Most grasses were associated with AM, but the colonization percentages were low in both C3 and C4 grasses. Nevertheless, the AM root colonization clearly decreased as the altitude increased. This distinctive pattern among different species was also observed between some of the populations of the same species sampled throughout the sites. An inverse relationship between altitude and AM colonization was found in this Southern Hemisphere Andean system. The effect of altitude on AM colonization seems to be more related to the grasses' photosynthetic pathway than to life cycles. This study represents the first report for this biogeographical region.","palabras_clave":"andean grasses|mycorrhizas|altitude gradient|arid environments"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88903,"idioma_id":5,"titulo":"Las explicaciones sobre el proceso genocida en los discursos de pobladores de Famaillá, Tucumán. 1975-1983","resumen":"El trabajo indaga los modos de narración y representación sobre el genocidio perpetrado durante el Operativo Independencia y la última dictadura militar que emergen en los discursos de pobladores del departamento de Famaillá. A partir del análisis de 18 entrevistas, se establecen dos matrices discursivas que tienen en común su estructuración en torno al repudio al accionar de los militares y se diferencian entre sí por el tipo de racionalidad que se configura en las explicaciones acerca del genocidio. El análisis de las formas a través de las cuales se representa y explica el pasado apunta a comprender el papel que estas desempeñan en el modo de significar el presente y el futuro.","palabras_clave":"OPERATIVO INDEPENDENCIA|FAMAILLÁ|REPRESENTACIONES SOCIALES|GENOCIDIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88904,"idioma_id":4,"titulo":"El proceso de construcción del Archivo Testimonial sobre el Operativo Independencia y la dictadura militar en Famaillá (Tucumán ? Argentina). Una revisión crítica","resumen":"El artículo se propone realizar una revisión crítica de la experiencia de construcción de un archivo testimonial. Constituye una reflexión teórico-metodológica de nuestras propias prácticas en las diferentes etapas de este proceso a la luz de la especificidad que supone el trabajo con víctimas del genocidio de las clases populares.  Este análisis parte de una caracterización del colectivo del que forman parte los entrevistados, entendiendo que la misma constituye un elemento central a la hora de dar cuenta de las dificultades y las potencialidades del trabajo realizado.  En tanto este proceso de construcción incluyó la realización de las entrevistas que conforman el archivo, la reflexión no sólo gira en torno a cuestiones vinculadas al armado del archivo, sino también a aspectos relacionados con la construcción de fuentes orales.","palabras_clave":"ARCHIVO ORAL|METODOLOGÍA|OPERATIVO INDEPENDENCIA|TUCUMÁN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88905,"idioma_id":4,"titulo":"cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit","resumen":"Changes that occur to  mammalian sperm upon epididymal transit and maturation render these cells  capable of moving progressively and capacitating. Signaling events leading to  mammalian sperm capacitation depend on the modulation of proteins by  phosphorylation and dephosphorylation cascades. Recent experiments have  demonstrated that the Src family of kinases plays an important role in the  regulation of these events. However, sperm from cSrc null mice display normal  tyrosine phosphorylation associated with capacitation. We report here that,  despite normal phosphorylation, sperm from cSrc null mice display a severe  reduction in forward motility, and are unable to fertilize in vitro.  Histological analysis of seminiferous tubules in the testes, caput and corpus  epididymis do not reveal obvious defects. However, the cauda epididymis is  significantly smaller, and expression of key transport proteins in the  epithelial cells lining this region is reduced in cSrc null mice compared to  wild type littermates. Although previously, we and others have shown the  presence of cSrc in mature sperm from cauda epididymis, a closer evaluation  indicates that this tyrosine kinase is not present in sperm from the caput  epididymis, suggesting that this protein is acquired by sperm later during  epididymal maturation. Consistent with this observation, cSrc is enriched in  vesicles released by the epididymal epithelium known as epididymosomes. Altogether,  these observations indicate that cSrc is essential for cauda epididymal  development and suggest an essential role of this kinase in epididymal sperm  maturation involving cSrc extracellular trafficking.","palabras_clave":"Src|epididymis|fertilization|capacitation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88906,"idioma_id":4,"titulo":"Mouse Sperm Membrane Potential Hyperpolarization Is Necessary and Sufficient to Prepare Sperm for the Acrosome Reaction","resumen":"Mammalian sperm are unable to fertilize the egg immediately after ejaculation; they acquire this capacity during migration in the female reproductive tract. This maturational process is called capacitation and in mouse sperm it involves a plasma membrane reorganization, extensive changes in the state of protein phosphorylation, increases in intracellular pH (pH(i)) and Ca(2+) ([Ca(2+)](i)), and the appearance of hyperactivated motility. In addition, mouse sperm capacitation is associated with the hyperpolarization of the cell membrane potential. However, the functional role of this process is not known. In this work, to dissect the role of this membrane potential change, hyperpolarization was induced in noncapacitated sperm using either the ENaC inhibitor amiloride, the CFTR agonist genistein or the K(+) ionophore valinomycin. In this experimental setting, other capacitation-associated processes such as activation of a cAMP-dependent pathway and the consequent increase in protein tyrosine phosphorylation were not observed. However, hyperpolarization was sufficient to prepare sperm for the acrosome reaction induced either by depolarization with high K(+) or by addition of solubilized zona pellucida (sZP). Moreover, K(+) and sZP were also able to increase [Ca(2+)](i) in non-capacitated sperm treated with these hyperpolarizing agents but not in untreated cells. On the other hand, in conditions that support capacitation-associated processes blocking hyperpolarization by adding valinomycin and increasing K(+) concentrations inhibited the agonist-induced acrosome reaction as well as the increase in [Ca(2+)](i). Altogether, these results suggest that sperm hyperpolarization by itself is key to enabling mice sperm to undergo the acrosome reaction.","palabras_clave":"CALCIUM IMAGING|FERTILIZATION|ION CHANNELS|PHOSPHORYLATION|SPERM|ACROSOME REACTION|CALCIUM|HYPERPOLARIZATION|SPERM CAPACITATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88907,"idioma_id":4,"titulo":"On the dynamics of cutting arc plasmas: the role of the power supply ripple","resumen":"The power sources used in cutting arc torches are usually poorly stabilized and have a large ripple factor. The strong oscillatory components in the voltage and arc current produce in turn, large fluctuations in the plasma quantities.Experimental observations on the dynamics of the nonequilibrium plasma inside the nozzle of a 30 A oxygen cutting torch with a 7 % ripple level of its power source are reported in this work. The observed electron temperature (mean value o 5400 K) shows a rms deviation o 5 % (¡Â 300 K), which is of the order of the arc voltage ripple level. A considerable different situation occurs with the plasma density (mean value o 3 ¢¥ 1019 m-3). In this case the rms deviation was o 75 %, much greater than that of theelectron temperature.o 5400 K) shows a rms deviation o 5 % (¡Â 300 K), which is of the order of the arc voltage ripple level. A considerable different situation occurs with the plasma density (mean value o 3 ¢¥ 1019 m-3). In this case the rms deviation was o 75 %, much greater than that of theelectron temperature.","palabras_clave":"Cutting |Arc plasmas|power supply|ripple"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88908,"idioma_id":4,"titulo":"Langmuir probe diagnostics of an atmospheric pressure vortex-stabilized nitrogen plasma jet","resumen":"Langmuir probe measurements in an atmospheric pressure direct current (dc) plasma jetare reported. Sweeping probes were used. The experiment was carried out using a dcnon?transferred arc torch with a rod?type cathode and an anode of 5 mm diameter. Thetorch was operated at a nominal power level of 15 kW with a nitrogen flow rate of 25 Nlmin-1. A flat ion saturation region was found in the current?voltage curve of the probe.The ion saturation current to a cylindrical probe in a high?pressure non local thermalequilibrium (LTE) plasma was modeled. Thermal effects and ionization\/recombinationprocesses inside the probe perturbed region were taken into account. Averaged radialprofiles of the electron and heavy particle temperatures as well as the electron densitywere obtained. An electron temperature around 11000 K, a heavy particle temperaturearound 9500 K and an electron density of about 4 × 1022 m-3, were found at the jetcentre at 3.5 mm downstream from the torch exit. Large deviations from kineticequilibrium were found throughout the plasma jet. The electron and heavy particletemperature profiles showed good agreement with those reported in the literature byusing spectroscopic techniques. It was also found that the temperature radial profilebased on LTE was very close to that of the electrons. The calculations have shown thatthis method is particularly useful for studying spraying?type plasma jets characterizedby electron temperatures in the range 9000?14000 K.","palabras_clave":"Langmuir probe |nitrogen jet |vortex stabilized"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88909,"idioma_id":4,"titulo":"A role for the membrane protein M6 in the Drosophila visual system","resumen":"Abstract Background Members of the proteolipid protein family, including the four-transmembrane glycoprotein M6a, are involved in neuronal plasticity in mammals. Results from our group previously demonstrated that M6, the only proteolipid protein expressed in Drosophila, localizes to the cell membrane in follicle cells. M6 loss triggers female sterility, which suggests a role for M6 in follicular cell remodeling. These results were the basis of the present study, which focused on the function and requirements of M6 in the fly nervous system. Results The present study identified two novel, tissue-regulated M6 isoforms with variable N- and C- termini, and showed that M6 is the functional fly ortholog of Gpm6a. In the adult brain, the protein was localized to several neuropils, such as the optic lobe, the central complex, and the mushroom bodies. Interestingly, although reduced M6 levels triggered a mild rough-eye phenotype, hypomorphic M6 mutants exhibited a defective response to light. Conclusions Based on its ability to induce filopodium formation we propose that M6 is key in cell remodeling processes underlying visual system function. These results bring further insight into the role of M6\/M6a in biological processes involving neuronal plasticity and behavior in flies and mammals. ","palabras_clave":"Myelin PLP family,|Eye development|phototaxis|Cell remodeling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88910,"idioma_id":4,"titulo":"Regulatory T cells but not NKT I cells are modulated by a single low-dose   Cyclophosphamide in a B cell lymphoma tumor-model","resumen":"Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg\/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells.","palabras_clave":"T regulatory cells|NKT I cells|cyclophosphamide|lymphoma"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88911,"idioma_id":4,"titulo":"First proteome of the egg perivitelline fluid of a freshwater gastropod with aerial oviposition","resumen":"Pomacea canaliculata is a freshwater snail that deposits eggs on   solid substrates above the water surface. Previous studies have   emphasized the nutritional and protective functions of the three most   abundant perivitelline fluid (PVF) protein complexes (ovorubin, PV2 and   PV3) during its embryonic development, but little is known about the   structure and function of other less abundant proteins. Using 2-DE,   SDS-PAGE, MALDI TOF\/TOF and LC-MS\/MS, we identified 59 proteins from the   PVF of P. canaliculata, among which 19 are novel. KEGG analysis   showed that the functions of the majority of these proteins are   \u201Cunknown\u201D (n = 34), \u201Cenvironmental information processing\u201D (10), 9 of   which are related to innate immunity, and \u201Cmetabolism\u201D (7). Suppressive   subtractive hybridization revealed 21 PVF genes to be specific to the   albumen gland, indicating this organ is the origin of many of the PVF   proteins. Further, the 3 ovorubin subunits were identified with   30.2-35.0% identity among them, indicating their common origin but   ancient duplications. Characterization of the PVF proteome has opened   the gate for further studies aiming to understand the evolution of the   novel proteins, and their contribution to the switch to aerial   oviposition.","palabras_clave":"POMACEA CANALICULATA|PERIVITELLIN FLUID|AMPULLARIIDAE|OVORUBIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88912,"idioma_id":4,"titulo":"L-Galactono-1,4-lactone dehydrogenase (GLDH) Forms Part of Three Subcomplexes of Mitochondrial Complex I in Arabidopsis thaliana","resumen":"L-Galactono-1,4-lactone dehydrogenase (GLDH) catalyzes the terminal step of the Smirnoff-Wheeler pathway for vitamin C (L-ascorbate) biosynthesis in plants. A GLDH in gel activity assay was developed to biochemically investigate GLDH localization in plant mitochondria. It previously has been shown that GLDH forms part of an 850-kDa complex that represents a  minor form of the respiratory NADH dehydrogenase complex (complex I). Because accumulation of complex I is disturbed in the absence of GLDH, a role of this enzyme in complex I assembly has been proposed. Here we report that GLDH is associated with two further protein complexes. Using native gel electrophoresis procedures in combination with the in gelGLDHactivity assay and immunoblotting, two mitochondrial complexes of  470 and 420 kDa were identified. Both complexes are of very low abundance. Protein identifications by mass spectrometry revealed that they include subunits of complex I. Finally, the 850-kDa complex was further investigated and shown to include the complete ?peripheral arm? of complex I. GLDH is attached to a membrane domain, which represents a major fragment of the ?membrane arm? of complex I. Taken together, our data further support a role of GLDH during complex I formation, which is based on its binding to specific assembly intermediates.","palabras_clave":"L-Galactono-1,4-lactone dehydrogenase|Mitochondrial Complex I|Arabidopsis thaliana|L-ascorbate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88913,"idioma_id":4,"titulo":"Phylogeography of Aedes Aegypti in Argentina: Long-Distance Colonization and Rapid Restoration of Fragmented Relicts After a Continental Control Campaign","resumen":"Aedes (Stegomyia) aegypti, the main vector of Dengue and Yellow Fever viruses, is present in all the northern andcentral provinces of Argentina. During 2009, a Dengue outbreak spread broadly throughout the country, causing27,752 infections in 13 provinces. In Argentina, little is known about the demographic history of this vector,which suffered a drastic decrease in abundance and distribution during a major control campaign performed inthe Americas between 1950 and 1960. With the aim of uncovering the past and present events that determinedthe present distribution of the genetic variability in Ae. aegypti populations, we analyzed the distribution andabundance of mitochondrial haplotypes obtained by sequencing a 450-bp fragment of the ND5 gene. We detected14 haplotypes among the sequences of 197 individuals from 22 populations that cover most of thedistribution of the species in Argentina; one population from Bolivia and one from Paraguay were also included.A high heterogeneity in the geographical distribution of the genetic polymorphism was observed, with a patternof isolation by distance in the north-west of Argentina. Haplotypes nested in three haplogroups, representingdifferent colonization events and evolutionary histories in distant geographical areas. North-western and northeasternpopulations correspond to independent introduced stocks for which a past fragmentation and rapidrestoration from highly polymorphic relicts were inferred. By contrast, a unique genetic variant was detected inthe east, probably as the result of a recent re-colonization event after the major control campaign; in this area, themosquito would have been practically eradicated as a consequence of the continental control campaign.","palabras_clave":"Aedes aegypti|Demographic history|Dengue|Phylogeography"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88914,"idioma_id":4,"titulo":"Silent Circulation of St. Louis Encephalitis Virus Prior to an Encephalitis Outbreak in Cordoba, Argentina (2005)","resumen":"St. Louis encephalitis virus is a complex zoonoses. In 2005, 47 laboratory-confirmed and probable clinical cases of SLEV infection were reported in Córdoba, Argentina. Although the causes of 2005 outbreak remain unknown, they might be related not only to virological factors, but also to ecological and environmental conditions. We hypothesized that one of the factors for SLE reemergence in Córdoba, Argentina, was the introduction of a new SLEV genotype (SLEV genotype III), with no previous activity in the area. In order to evaluate this hypothesis we carried out a molecular characterization of SLEV detections from mosquitoes collected between 2001 and 2004 in Córdoba city. A total of 315 mosquito pools (11,002 individuals) including 12 mosquitoes species were analyzed. Overall, 20 pools (8 mosquitoes species) were positive for SLEV. During this study, genotypes II, V and VII were detected. No mosquito pool infected with genotype III was detected before the 2005 outbreak. Genotype V was found every year and in the 8 sampled sites. Genotypes II and VII showed limited temporal and spatial activities. We cannot dismiss the association of genotype II and V as etiological agents during the outbreak. However, the silent circulation of other SLEV strains in Córdoba city before the 2005 outbreak suggests that the introduction of genotype III was an important factor associated to this event. Not mutually exclusive, other factors such as changes in avian hosts and mosquitoes vectors communities, driven by climatic and environmental modifications, should also be taken into consideration in further studies.","palabras_clave":"SAINT LOUIS ECEPHALITIS|SILENT VIRUS CIRCULATION|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88915,"idioma_id":4,"titulo":"Oldest record of the Great White Shark (Lamnidae, Carcharodon; Miocene) in the Southern Atlantic","resumen":"Lamnid  teeth  close  to  but  more  plesiomorph  than  Carcharodon  carcharias  were  collected  in  the  lateMiocene  beds  of  the  Parana ´ Formation  in  the  central  eastern  Argentina.  We  propose,  as  other  authors,that  some  species  formerly  assigned  to  Isurus  or  to  Cosmopolitodus  should  be  included  in  Carcharodon.Some  workers  suggested  that  C.  carcharias  originated  by  phyletic  evolution  in  the  Paci&#64257;c  basin.  The  teethfrom  Parana ´ could  pertain  to  a  new  species  of  Carcharodon  already  known  from  Peru ´ .  In  contrast  with  thePaci&#64257;c  basin,  Carcharodon  sp.  was  sympatric  with  the  wide  toothed  species  Carcharodon  plicatilis  incentral  Argentina.  This  is  the  oldest  record  of  Carcharodon  in  the  southern  Atlantic","palabras_clave":"Elasmobranchii|Lamniformes|Entre Ríos|Neogene"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88916,"idioma_id":4,"titulo":"Molecular identification of the sperm selection involved porcine sperm binding glycoprotein (SBG) as deleted in malignant brain tumors 1 (DMBT1)","resumen":"Porcine sperm binding glycoprotein (SBG) is involved in sperm-oviduct interaction. Here we use mass spectrometry to identify SBG, finding peptides corresponding to deleted in malignant brain tumors 1 (DMBT1), at scavenger receptor cysteine-rich (SRCR) and CUB domains. RT-PCR allowed the cloning of unique sequences, belonging to porcine DMBT1. Western blot and immunofluorescence of oviductal tissues using anti-SBG and anti-hDMBT1 antibodies showed identical results. The biochemical characteristics of both proteins are coincident. We conclude that porcine SBG is an oviductal form of DMBT1, and thus assign this protein a novel location andfunction","palabras_clave":"DMBT1|SBG|espermatozoide|oviducto"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88917,"idioma_id":4,"titulo":"Apical membranes prepared by peeling from whole porcine oviducts interact with homologous sperm","resumen":"In mammals, interaction between sperm and oviductal epithelial cells provides the formation of asperm reservoir and sperm selection at the isthmus of the oviduct. Several in vitro methods are used to study this interaction. Apical plasma membranes (APM) have been prepared by peeling from culture and differentiated kidney cells. In this work, we modify this method, using it for the preparation of APM directly from the whole oviduct, proving purity of the apical plasma membranes obtained by western blot for proteins of known specific locations. The obtained APM correspond only to the most differentiated cells, exposed at the lumen of the organ. Also, the prepared APM are shown by biotinylation to interact with sperm. The binding is at the head of sperm and induces on them prolonged motility and tyrosine phosphorylation of proteins of masses 92, 97, 210 and 220 kDa. The tyrosine phosphorylation of p97 has been previously described as an effect of the apical membrane exposed sperm binding glycoprotein (SBG), which is shown to be present in the preparations described here. Upon treatment with APM, the tyrosine phosphorylation pattern of sperm changes from heads to tail. Thus, we describe an easy method for APM preparation directly from organs that allows&nbsp;","palabras_clave":"peeling|boar sperm |apical membrane|biotinylation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88918,"idioma_id":4,"titulo":"The effect of oviductal deleted in malignant brain tumor 1 (DMBT1) over porcine sperm is mediated by a signal transduction pathway that involves pro-AKAP4 phosphorylation","resumen":"The interaction between sperm and the oviduct results in the selection   of sperm with certain qualities. Porcine oviductal                          deleted in malignant brain tumor 1, DMBT1   (previously called sperm binding glycoprotein, SBG) has been proposed to   be implicated                          in sperm selection through acrosome alteration   and suppression of motility of a subpopulation of sperm that have began   capacitation                          prematurely. It produces in vitro acrosome   alteration and decrease of motility of boar sperm, concomitant with   tyrosine-phosphorylation                          of a 97 kDa sperm protein (p97). We hypothesized   that the phosphorylation of p97 may be a link between DMBT1 sensing by a                          subpopulation of boar sperm and its biological   effect. In this work, p97 was identified by mass spectrometry and   immunoprecipitation                          as a porcine homologue of AKAP4. Pro-AKAP4 was   localized by immunofluorescence and subcellular fractionation to the   periacrosomal                          membranes and was shown to be   tyrosine-phosphorylated by DMBT1 regardless of the presence of calcium   or bicarbonate, and of                          cAMP analogs, PKA inhibitors or a PKC inductor. A   processed ~ 80 kDa form of AKAP4 was also detected at the tail of boar   sperm,                          which was not tyrosine-phosphorylated by DMBT1   under the conditions tested. Immunohistochemistry of testis showed   AKAP4´s                          presence in boar sperm precursor cells. The   evidence presented here supports the involvement of AKAP4 in the   formation of                          the fibrous sheath on boar precursor sperm cells   and implicates the phosphorylation of pro-AKAP4 as an early step in the   signal                          transduction pathway gated by DMBT1 that leads   to sperm selection through acrosome alteration.","palabras_clave":"Boar sperm|phosphorylation|AKAP4|Oviduct"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88919,"idioma_id":5,"titulo":"RELIGIOSIDAD POPULAR EN EL SIGLO XXI: TRANSFORMACIONES DE LA DEVOCIÓN  A SAN LA MUERTE EN BUENOS AIRES","resumen":"En este trabajo abordamos la devoción a San la Muerte de creciente visibilidad y expansión a lo largo del territorio argentino, en un contexto que permite un mayor desenvolvimiento de expresiones de fe no-católicas y favorecido por el dinamismo propio de este culto. Pretendemos comparar las características actuales de esta devoción en santuarios del conurbano bonaerense con una serie de textos folklóricos que refieren a una versión tradicional de la misma. Este contraste permite percibir cambios en las representaciones y prácticas de los devotos. Su estética particular se presta a diversas apropiaciones -no siempre religiosas-, como su adopción por personas que conviven cotidianamente con situaciones de violencia y conflicto con la ley. Este hecho es recogido por los medios de comunicación, los cuales refuerzan este vínculo con el delito y transforman la devoción en una marca de refuerzo de la peligrosidad de quienes portan esta imagen, generalizando un estigma que aumenta el costo social de profesar este culto.","palabras_clave":"Religiosidad popular|Latinoamérica|santuario|rituales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88920,"idioma_id":5,"titulo":"Caracterización de la zona de El Rincón (Provincia de Buenos Aires) como área de reproducción de peces costeros","resumen":"Con el objetivo de caracterizar la zona de reproducción de peces de El Rincón, durante la Campaña EH-03\/08 (noviembre de 2008) se capturaron peces adultos con una red de arrastre de fondo; se tomaron muestras de huevos y larvas de peces con una red Nackthai y se efectuaron mediciones de salinidad y temperatura empleando un CTD. La región se caracteriza por un frente oceanográfico formado por aguas diluidas por la descarga de los ríos Negro y Colorado; aguas de alta salinidad originadas en el Golfo San Matías; y aguas de salinidad intermedia de la plataforma continental. Se identificaron huevos y\/o larvas de anchoíta; pez palo; mero; besugo; palometa; pampanito; lenguados y esciénidos; y hembras grávidas de pescadilla; besugo; pez palo; salmón; mero; palometa; lenguados; testolín; chanchito; trilla; cocherito y lucerna. En base a estos resultados y a la información existente, se propone que el establecimiento de un área de desove multiespecífica en la región está favorecido por la existencia de una celda de recirculación que produciría la retención de huevos y larvas en la zona, la abundancia de componentes del zooplancton que sirven de alimento a las larvas, y la cercanía con un área de cría de juveniles en la zona de marismas y canales de marea que va desde Bahía Blanca hasta la desembocadura del Río Negro.","palabras_clave":"ICTIOPLANCTON|REPRODUCCIÓN DE PECES|ÁREAS DE CRIA|EL RINCON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88921,"idioma_id":4,"titulo":"Oxidation of Hydrogenated Si(111) by a Radical Propagation Mechanism","resumen":"The reactivity of the hydrogenated Si(111) surface toward H2O and O2 was investigated in order to elucidate the mechanism of oxidation of the first silicon bilayer in air. Density functional theory calculations were performed to identify elementary reaction steps and their corresponding activation energy barriers. The perfect surface is unreactive toward H2O and O2 at room temperature as deduced from the high energy barriers found. However, isolated Si dangling bonds, (Si3)Si·, surrounded by SiH groups, readily react with O2 (but not with H2O), producing a silanone intermediate of the form (Si2O)SiO· where one of the silicon back bonds is oxidized. This intermediate is reached after a series of elementary steps with very small activation energy barriers. In the next step, the oxygen atom of the silanone group inserts into a Si\u2013Si back bond, and the surface silicon dangling bond is regenerated as a (SiO2)Si· moiety in which the silyl group has two oxidized back bonds. This initiates a surface chain reaction in which the oxidized silyl group abstracts a hydrogen atom from a neighboring SiH thus producing a new Si dangling bond that is oxidized by O2 in the next step of the chain reaction. This radical propagation mechanism explains the two-dimensional oxide growth in air and the lack of surface SiOH groups. Therefore, the oxidation of the H\u2013Si(111) surface requires the presence of radicals in air that, upon reaction with the hydrogenated surface, produce silicon dangling bonds where the oxidation begins and propagates by hydrogen abstraction from nonoxidized neighboring SiH groups.","palabras_clave":"silicon|radical mechanism|oxidation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88922,"idioma_id":4,"titulo":"A novel method to prepare highly enriched primary cultures of chicken retinal horizontal cells","resumen":"The retina is a heterogeneous tissue composed of different neuronal cells (photoreceptor (PRC), horizontal (HC), amacrine, bipolar and retinal ganglion RGC cells) and glial cells. Our aim in this work was to purify HCs from the chicken embryonic retina to obtain primary cultures highly enriched in these cells for further characterization. To this end, disaggregated retinas of chicken embryos at day 15 were subjected to a discontinuous bovine serum albumin (BSA) gradient of concentrations raging from 1 to 4%. After centrifugation, cells collected from the different phases were cultured for 4 days and characterized by immunochemistry and cell morphology.&nbsp;Phases&nbsp;were examined&nbsp;with&nbsp;specific antibodies against HC markers such as PROX-1, Islet-1 and calretinin, together with markers for other retinal cell populations. The results show that&nbsp;only in the&nbsp;fraction corresponding to&nbsp;2.5% BSA&nbsp;did most of the cells display PROX-1&nbsp;and Islet-1 positive immunoreactivities with a typical HC morphology. Moreover, Western blot assays indicate that the 2.5 % BSA phase exhibits the strongest PROX-1 immunolabeling, denoting the typical molecular weight (MW) of ~ 83KDa. Based on an accurate morphological analysis, a number of cells in this fraction resembled H1- and H3-type HCs (axon-bearing ?brush-shaped? and axon-less ?candelabrum-shaped? HCs respectively). In conclusion, the BSA gradient&nbsp;has so far proved to be a simple yet very useful method to selectively separate&nbsp;specific retinal cell types for the further study and characterization of their molecular, biochemical and&nbsp;electrophysiological properties. ","palabras_clave":"retina|horizontal cell|isolation|chicken"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88923,"idioma_id":4,"titulo":"Differential Regulation of Arylalkylamine N-Acetyltransferase Activity in Chicken Retinal Ganglion Cells by Light and the Circadian Clock","resumen":"          Retinal ganglion cells (RGCs) contain circadian clocks driving melatonin synthesis during the day, a subset of these cells acting as nonvisual photoreceptors sending photic information to the brain. In this work, the authors investigated the temporal and light regulation of arylalkylamine N-acetyltransferase (AA-NAT) activity, a key enzyme in melatonin synthesis. The authors first examined this activity in RGCs of wild-type chickens and compared it to that in photoreceptor cells (PRs) from animals maintained for 48 h in constant dark (DD), light (LL), or regular 12-h:12-h light-dark (LD) cycle. AA-NAT activity in RGCs displayed circadian rhythmicity, with highest levels during the subjective day in both DD and LL as well as in the light phase of the LD cycle. In contrast, AA-NAT activity in PRs exhibited the typical nocturnal peak in DD and LD, but no detectable oscillation was observed under LL, under which conditions the levels were basal at all times examined. A light pulse of 30\u201360 min significantly decreased AANAT activity in PRs during the subjective night, but had no effect on RGCs during the day or night. Intraocular injection of dopamine (50 nmol\/eye) during the night to mimic the effect of light presented significant inhibition of AA-NAT activity in PRs compared to controls but had no effect on RGCs. The results clearly demonstrate that the regulation of the diurnal increase in AA-NAT activity in RGCs of chickens undergoes a different control mechanism from that observed in PRs, in which the endogenous clock, light, and dopamine exhibited differential effects.      ","palabras_clave":"Arylalkylamine N-acetyltransferase|Circadian rhythms|Melatonin|Retinal Ganglion Cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88924,"idioma_id":4,"titulo":"Phospholipid turnover and phospholipase D activity in tobacco hairy roots exposed to phenol","resumen":"Plants are exposed to a great variety of environmental factors, which can affect their survival. In addition, the rapid urbanization and the increased release of different pollutants, such as phenol, to the environment, produce another stressful condition to the development and growth of the plants. In this work, we studied the effects on the [32P]Piphospholipid turnover and phospholipase D (PLD) activity after phenol treatment, using tobacco hairy roots (HRs), double transgenic (DT) for two peroxidase genes (tpx1 and tpx2) and wild type (WT) ones. In both HRs, the [32P]phospholipid turnover of the most abundant phospholipids  (PLs), such as phosphatidylcholine (PC), phosphatydilethanolamine (PE), phosphatydilglycerol (PG) and cardiolipin (CL) did not show any changes after phenol treatment. However, modifications in the minor PLs of both HRs were observed. Phenol treatment significantly increases the turnover of phosphatidic acid (PA) and phosphatydilinositol (PI), in WT HRs. In DT HRs, phenol produced significant increase in the turnover of PI, lisophosphatidic acid (LPA), diacylglycerolpyrophosphate (DGPP) and PA with a concomitant decrease in the phosphatidylinositol monophosphate (PIP). Moreover, phosphatidylinositol bisphosphate (PIP2) was detected, but its level did not change in presence of the pollutant. Phenol  treatment significantly increased the PLD activity of both HRs. In WT HRs the increase was 100% higher than the control, whereas in DT HRs it was about to 50%. These results suggest the participation of minor  PLs, mainly PA, and the PLD pathway as one source of PA production in the activation of intracellular mechanisms that might be important in the response of these plant tissues to phenol treatment.","palabras_clave":"Phospholipid turnover  |Phenol|Phospholipase D|Lipid signal transduction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88925,"idioma_id":4,"titulo":"Phytoremediation of Phenol at pilot scale by tobacco hairy roots","resumen":"Abstract  Phenol  is  a  toxic  compound  commonly  found  in  the  wastewater  released  from  several industries. In the present work, we optimized the use of tobacco hairy roots (HRs), wild type (WT)  and  double  transgenic  (DT)  for  two  peroxidases,  as  an  alternative  strategy  for  the treatment  of  this  pollutant. The  optimal  conditions  for  the  removal  process were  evaluated using different phenol (100-800 mg L-1) and H2O2 (2,5-10 mM) concentrations. Tobacco HRs were able to remove solutions with increasing phenol concentrations. Regarding the effect of exposition  time,  prolonged  time  of  treatment  improved  phenol  remediation  when  high pollutant  concentrations  were  used.  A  decrease  in  basic  peroxidase  (Px)  isoenzymes  was detected after phenol  treatment. Kinetic  studies were performed using different Px extracts, such  as  soluble Px  (SPx)  and  ionically  bound Px  (IBPx)  from WT  and DT HRs. SPx  and IBPx  extracts  from DT HRs,  showed  high  affinity  towards  phenol  as  substrate  and  higher catalytic  efficiency  than  extracts  derived  from WT HRs. Moreover,  IBPx  extract  from DT HRs, showed the highest catalytic efficiency, demonstrating that these HRs could provide an adequate matrix for the successful phenol removal.","palabras_clave":"PHYTOREMEDIATION|ORGANIC POLLUTANTS | TRANSGENIC PEROXIDASES|KINETIC PARAMETERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88926,"idioma_id":4,"titulo":"Determination of storage tanks location for optimal short-term scheduling in multipurpose\/multiproduct batch-continuous plants under uncertainties","resumen":"A multipurpose\/multiproduct plant has to deal with many combinations of tasks sequences and operation rates that lead to accumulation problems. These problems can be handled using storage tanks, but usually their location within the flowsheet is predetermined and not subject to optimization, missing the opportunity to better satisfy the customers. In this work we will determinate the optimal location of storage tanks for the short-term scheduling under uncertainty. A hybrid simulation-based optimization (SBO) strategy was developed and implemented to solve the problems combining stochastic and deterministic solution algorithms.","palabras_clave":"DECISION-MAKING|UNCERTAINTY|SIMULATION-BASED OPTIMIZATION|BATCH PLANT|SEMI-CONTINUOUS PLANT|SCHEDULING|MULTIPURPOSE\/MULTIPRODUCT PLANTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88927,"idioma_id":4,"titulo":"Design and Planning of the Bioethanol Supply Chain via Simulation-Based Optimization: The case of Argentina","resumen":"This paper addresses the strategic planning of bioethanol supply chains (SC)under uncertainty in the demand. The design problem is setting as a reformulation of a multiscenariomixed-integer linear programming (MILP) problem. It consists in the adoption of asimulation-based optimization scheme to accommodate the variables belonging to differentmanagement levels. The strategy supports decisions on the capacity expansions of theproduction and storage facilities of the network over time along with the associated planningdecisions (i.e., production rates, sales, etc.). The capability of the approach is demonstratedthrough a case study based on the Argentinean sugarcane industry. Results include theinvestment strategy for the optimal SC configuration.","palabras_clave":"SUPPLY CHAIN MANAGEMENT|UNCERTAINTY|SUGARCANE INDUSTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88928,"idioma_id":4,"titulo":"Origin and detectability of co-orbital planets from radial velocity data","resumen":"We analyse the possibilities of detection of hypothetical exoplanets in co-orbital motion from synthetic radial velocity (RV) signals, taking into account different types of stable planar configurations, orbital eccentricities and mass ratios. For each nominal solution corresponding to small-amplitude oscillations around the periodic solution, we generate a series of synthetic RV curves mimicking the stellar motion around the barycentre of the system. We then fit the data sets obtained assuming three possible different orbital architectures: (a) two planets in co-orbital motion, (b) two planets in a 2\/1 mean-motion resonance (MMR) and (c) a single planet. We compare the resulting residuals and the estimated orbital parameters.  For synthetic data sets covering only a few orbital periods, we find that the discrete RV signal generated by a co-orbital configuration could be easily confused with other configurations\/systems, and in many cases the best orbital fit corresponds to either a single planet or two bodies in a 2\/1 resonance. However, most of the incorrect identifications are associated with dynamically unstable solutions.    We also compare the orbital parameters obtained with two different fitting strategies: a simultaneous fit of two planets and a nested multi-Keplerian model. We find that, even for data sets covering over 10 orbital periods, the nested models can yield incorrect orbital configurations (sometimes close to fictitious MMRs) that are nevertheless dynamically stable and with orbital eccentricities lower than the correct nominal solutions.    Finally, we discuss plausible mechanisms for the formation of co-orbital configurations, by the interaction between two giant planets and an inner cavity in the gas disc. For equal-mass planets, both Lagrangian and anti-Lagrangian configurations can be obtained from same initial condition depending on final time of integration.","palabras_clave":"techniques|radial velocities|celestial mechanics|planets and satellites formationj"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88929,"idioma_id":4,"titulo":"Mechanism of photooxidation of Heptafluorobutyl anhydride in the presence of NO2. Synthesis and characterization of heptafluoropropyl peroxynitrate, CF3CF2CF2OONO2","resumen":"&nbsp;The photolysis of heptafluorobutyric anhydrideat 254 nm in the presence of NO2 and O2 has been studied. Itleads to the formation of CF3CF2CF2OONO2, CF3CF2OONO2,and CF2O as the only fluorine-containing carbonaceous prod-ucts. The formation of the new heptafluoropropyl peroxynitrate(HFPN, CF3CF2CF2OONO2), as one of the main products, isa consequence of the formation of CF3CF2CF2OO? radicalsfollowed by the reaction with NO2. To characterize HFPN, theUV absorption cross sections and their temperature dependencebetween 245 and 300 K have been measured over thewavelength range 200&#8722;300 nm as well as the infrared absorption cross sections. Kinetic parameters for its thermal decompositionare also presented in the temperature range between 281 and 300 K. The Rice&#8722;Ramsperger&#8722;Kassel&#8722;Marcus calculation reveals thatthe rate coefficient for the thermal decomposition at 285 K is almost independent of total pressure. The mechanism for thedecomposition of CF3CF2CF2OONO2 in the presence of NO was adjusted by a kinetic model, which enabled the calculation ofimportant rate coefficients.","palabras_clave":"peroxinitratos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88930,"idioma_id":4,"titulo":"Isolation and characterization of CH3OC(O)OOC(O)F from the reaction  CH3OH + FC(O)OOC(O)F","resumen":"The synthesis of CH3OC(O)OOC(O)F is accomplished by the thermal reaction between CH3OH and FC(O)OOC(O)F at room temperature. The new peroxide is obtained in pure form after repeated trap-to-trap condensation and it is characterized by NMR and IR spectroscopy and mass spectrometry. Geometrical parameters were studied by ab initio methods [B3LYP\/6-31++G(d,p)]. CH3OC(O)OOC(O)F isstable for a few hours at room temperature, and it decomposes into CO2, CO, HF, HC(O)OH, and CH2O. The boiling point is extrapolated to 366.5 K from the vapor pressure curve log p = 8.623\u20132061\/T (p \/mbar, T \/K). The mechanisms for boththe formation and thermal decomposition of CH3OC(O)OOC(O)F are discussed, and some physicochemical properties are compared with those of related compounds.","palabras_clave":"fluorinated compounds"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88931,"idioma_id":4,"titulo":"Photooxidation of CF3CF2C(O)Cl in the presence of NO2. Synthesis and characterization of pentafluoroethyl peroxynitrate, CF3CF2OONO2","resumen":"The photolysis of CF3CF2C(O)Cl in the presence of NO2 and O2 at 254 nm leads initially to the formation of CF3CF2OONO2, CF2O, and CO as the main carbonaceous products. The NO2 concentration governs the identity of the products. As photolysis continues the NO2 concentration gradually decreases until newchannels open up and the mechanism leads to the formation of CF2O, CO2 and CF3OC(O)OONO2.In addition to the study of the mechanism, we present in this paper some characteristics of the pentafluoroethyl peroxynitrate, CF3CF2OONO2 such as the infrared spectrum with the associated absorption cross-sections for the main peaks and kinetic parameters for its thermal decomposition at total pressures of 9.0 and 250 mbar (Ea = 87.7 kJ\/mol, A = 3.8×1013; and Ea = 96.7 kJ\/mol, A = 2.37×1015, respectively) which show that they are dependent both on the temperature and on the total pressure.","palabras_clave":"photooxidation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88932,"idioma_id":4,"titulo":"Synthesis and properties of trifluoromethoxyl fluoroformyl anhydride, CF3OC(O)OC(O)F","resumen":"In the present work the synthesis of the trifluoromethoxyl fluoroformyl anhydride is presented for the first time. Two strategies were employed to obtain CF3OC(O)OC(O)F: the thermal decomposition of CF3OC(O)OOOC(O)F in excess of CO, and the reaction between CF3OC(O)OOC(O)F, FC(O)OOC(O)F and CO.A mechanism was proposed taking into account reaction rates and thermal stability of the intermediates.DFT calculations at B3LYP\/6-311+G* level were used to explore the conformational space of this molecule and the relative populations of conformers at room temperature, and to simulate the experimental vibrational spectrum. This molecule completes the family of the asymmetric oxygen bonded acyl compounds CF3OC(O)\u2013Ox\u2013C(O)F with x = 1\u20133.","palabras_clave":"fluorinated compounds"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88933,"idioma_id":4,"titulo":"Rodent diversity and habitat use in a protected area of Buenos Aires province, Argentina","resumen":"Habitat use of rodents is associated to environmental variables, species requirements and biologicalinteractions. The aim of this study was to analyse the macro and microhabitat use and spatial variation in the abundance of small wild rodents that inhabit Otamendi Natural Reserve, Argentina. We studied the rodent communities in 6 habitats: riparian forest, Celtis tala forest, lowland grassland, salt marsh and 2 highland grasslands. We captured a total of 153 individual of Scapteromys aquaticus, Akodon azarae, Oxymycterus rufus, Oligoryzomys flavescens, Deltamyskempi and O. nigripes, with a trapping effort of 3636 trap-nights. The species richness is maintained by the presence of different habitats that satisfy specific requirements from specialist and generalist species, using differentially the reserve and forming communities of different specific composition in each habitat. A differential macrohabitat use was observed by all species, and a certain level of selectivity at microhabitat scale was observed in individuals of 2 species.This study shows that the diversity of environments in the Otamendi Natural Reserve, which allows the maintenance of many wild species of small rodents; confirming the high ecological and conservational value of the reserves inside an urban region.","palabras_clave":"diversity|natural reserve|small rodents|use of habitat"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88934,"idioma_id":5,"titulo":"La fundación práctica de la teoría desde un punto de vista hermenéutico-trascendental","resumen":"El siguiente trabajo intenta reconstruir la recepción crítica de la hermenéutica filosófica por parte de Karl-Otto Apel. En primer lugar, siguiendo a Ricoeur, se presenta una reconstrucción histórico-filosófica de la hermenéutica desde Schleiermacher a Gadamer. Luego, se explica la asunción del 'problema hermenéutico' por parte de Apel y su propuesta de una hermenéutica trascendental. A continuación, desde esta perspectiva, se muestra la relación que existe entre la hermenéutica y las ciencias sociales. Por último, una breve introducción al planteo de la ética del discurso de Apel permite visualizar (esquemáticamente) la dimensión normativa del entendimiento comunicativo (Verständigung) que se encuentra a la base de todo proceso de conocimiento.","palabras_clave":"Karl-Otto Apel|Hermenéutica trascendental|Teoría y Praxis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88935,"idioma_id":4,"titulo":"Methyl Red - A Chameleon That Reveals The Partition Between Two Phases As A Function Of pH  An Extraction Experiment","resumen":"?A picture is worth a thousand words,? and besides it is easier to remember. This work is based on that premise, and its main objective is to show that creating a strong visual impact on the student?s mind is a useful tool to teach important chemistry concepts. The activities proposed involve a biphasic medium composed of an aqueous solution at different pH levels and petroleum ether (60?80°C), where an acid-basic indicator such as methyl red is employed to examine the phenomenon occurring in each phase, as it changes its color like a ?chameleon.? During the process, students are introduced to core concepts of physical chemistry through a solvent partition system. The experiment is suitable for both qualitative and quantitative analyses of the extraction process.","palabras_clave":"Methyl red|Extraction experiment|Physical chemistry|Distribution ratio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88936,"idioma_id":4,"titulo":"First-principles calculations of structural properties of NaNbO3","resumen":"We present ab-initio total energy calculations for different structures of NaNbO3 at  different volumes using two different exchange-correlation functionals: the Perdew and  Wang version of the local-density approximation (LDA) and the Wu and Cohen version  of the generalized gradient approximation (GGA-WC). We found that LDA not only underestimates  the equilibrium volume of the system but also predicts an incorrect ground  state for this oxide. The GGA-WC functional, on the other hand, significantly improves  the equilibrium volume and provides a relative phase stability in better agreement with  experiments. We then use the GGA to investigate the presence of structural instabilities  as a function of volume in order to provide insights for the understanding of the  structural behavior of K1-xNaxNbO3 solid solutions.","palabras_clave":"Ferroelectricos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88937,"idioma_id":5,"titulo":"Repensar el humanismo y la racionalidad: Aportes desde la filosofía de Karl-Otto Apel","resumen":"El siguiente trabajo intenta realizar un aporte a la recuperación y reformulación del concepto de humanismo en nuestro contexto histórico y filosófico actual desde el punto de vista de la filosofía de Karl-Otto Apel. En primer lugar, se analiza la categoría apeliana de 'crítica total de la razón' con la que se sintetiza el núcleo de convergencia de las principales corrientes actuales de pensamiento, como por ejemplo el posmodernismo, el postestructuralismo y el neopragmatismo. Precisamente, tal núcleo consistiría para Apel en un radical cuestionamiento de la racionalidad en cuanto tal. En una reconstrucción de estas posiciones se pueden reconocer dos antecedentes fundamentales y fundantes: Nietzsche y Heidegger. En segundo lugar, se explican los elementos centrales de una renovación (o ampliación) del concepto de racionalidad, entendida en términos consensual-comunicativos. Aquí encontramos un punto de contacto entre las corrientes señaladas y la filosofía discursiva de Apel: la crítica al concepto moderno de sujeto y su propuesta de superación.","palabras_clave":"Karl-Otto Apel|Racionalidad |Humanismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88938,"idioma_id":4,"titulo":"Off-center impurities in a robust ferroelectric material: case of Li in KNbO3","resumen":"The in&#64258;uence of Li impurities on the phase transition sequence of KNbO3 is investigated using an atomistic  model with parameters &#64257;tted to &#64257;rst-principles calculations. We &#64257;nd that the replacement of K by Li ions  increases local electric dipoles due to a large Li off-centering along [001] directions. Li doping strongly  affects the transition temperatures of KNbO3 as a result of the coupling between the off-center Li relaxation  dynamics and the macroscopic polarization of the host material. This coupling produces a decrease in the  temperatures for the rhombohedral-orthorhombic and orthorhombic-tetragonal phase transitions, while the  temperature of the cubic-tetragonal ferroelectric phase transition increases. The Li relaxation mechanism in  the different phases of KNbO3 provides a simple framework to understand the transition temperature shifts.","palabras_clave":"FERROELECTRICS|PIEZOELECTRICTS|AB-INITIO|MOLECULAR DYNAMICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88939,"idioma_id":4,"titulo":"Multiferroic behavior of Aurivillius Bi4Mn3O12 from first principles","resumen":"The multiferroic behavior of the hypothetical Aurivillius compound Bi4 Mn3 O12 has been explored on the basisof density functional calculations. We &#64257;nd that the tetragonal paraelectric phase of this material is ferromagnetic,showing ferroelectric and antiferrodistortive instabilities similar to the ones observed in its ferroelectric parentcompound Bi4 Ti3 O12 . Our results indicate, however, that the presence of Mn+4 ions at the B sites shrinks the cellvolume and, consequently, the unstable polar mode, associated with the ferroelectric polarization, is overcomeby an antiferrodistortive distortion. In this way, Bi4 Mn3 O12 exhibits incipient ferroelectricity at its equilibriumvolume. We show that the ferroelectric state can be favored by strain or partial substitution of Mn with Ti.","palabras_clave":"MULTIFERROIC|FIRST PRINCIPLES|AURIVILLIUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88940,"idioma_id":4,"titulo":"Brucella abortus-Infected Macrophages Modulate T Lymphocytes to Promote Osteoclastogenesis via IL-17","resumen":"Abstract              The pathogenic mechanisms of bone loss caused by   Brucella species have not been completely deciphered. Although T   lymphocytes (LTs) are considered important to control infection, the   mechanism of Brucella-induced T-cell responses to immunopathological   features is not known. We present in vitro and in vivo evidence showing   that Brucella abortus-induced inflammatory response leads to the   activation of LTs, which further promote osteoclastogenesis.   Pre-activated murine LTs treated with culture supernatant from   macrophages infected with B. abortus induced bone marrow-derived   monocytes (BMMs) to undergo osteoclastogenesis. Furthermore,   osteoclastogenesis was mediated by CD4(+) T cells. Although B.   abortus-activated T cells actively secreted the pro-osteoclastogenic   cytokines RANKL and IL-17, osteoclastogenesis depended on IL-17, because   osteoclast generation induced by Brucella-activated T cells was   completely abrogated when these cells were cultured with BMMs from IL-17   receptor knockout mice. Neutralization experiments indicated that IL-6,   generated by Brucella infection, induced the production of   pro-osteoclastogenic IL-17 from LTs. By using BMMs from tumor necrosis   factor receptor p55 knockout mice, we also demonstrated that IL-17   indirectly induced osteoclastogenesis through the induction of tumor   necrosis factor-&#945; from osteoclast precursors. Finally, extensive and   widespread osteoclastogenesis was observed in the knee joints of mice   injected with Brucella-activated T cells. Our results indicate that   activated T cells, elicited by B. abortus-infected macrophages and   influenced by the inflammatory milieu, promote the generation of   osteoclasts, leading to bone loss. ","palabras_clave":"Bruecella abortus|Macrophages|IL-17|Osteoclastogenesis modulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88941,"idioma_id":4,"titulo":"Persistence of Trichinella spiralis muscle larvae in natural decaying mice","resumen":"The influence of natural weather conditions onthe viability and reproductive capability of Trichinella spiralismuscle larvae in mouse corpses exposed to summerand winter conditions in the Buenos Aires Province,Argentina, was studied. For this purpose, a total of 49 mousecorpses harbouring muscle larvae of T. spiralis were exposedfor a period of 1, 2, 4 and 6 weeks in each of theseasons. Control corpses maintained at 8°C were also included.In summer, T. spiralis muscle larvae were recoveredfrom corpses exposed up to 1 week only. The viability ofthese larvae was 54.2%, and the reproductive capabilityindex in mice (RCI) was 13.1 and significantly lower thanthe control (p&lt;0.0005). Morphologic deterioration and reductionin the glycogen content of cysts and larvae wereobserved at the second week of exposition. By week 4,larval stages of Dermestes maculatus were observed insidecorpses, and 22 live muscle larvae of T. spiralis wereobtained by artificial digestion of their bodies. In winter, T.spiralis muscle larvae were always recovered, the viabilitybeing almost 100% except for a significant reduction byweek 6 of exposition (p&lt;0.0001). For this season, the RCIwere 50.5, 46.9, 59.7 and 45.2 for the periods of 1, 2, 4 and6 weeks of exposition, respectively. The morphology ofcysts and larvae did not show alterations, and no variationswere observed as well in glycogen reserves during the6-week period of exposition. RCI of non-exposed musclelarvae were always significantly higher that any of thoserecorded from muscle larvae that belonged to exposedcorpses (p00.0005). The present results demonstrate thatmuscle larvae of T. spiralis are able to survive in natureand keep infective for a 1-week period in summer and atleast for 6 weeks in winter, becoming an importantsource of infection for scavengers. In summer, larvaestages of D. maculatus, and probably other insects, mayplay an important role in the survival and transmission ofT. spiralis in the sylvatic cycle.","palabras_clave":"TRICHINELLA SPIRALIS|SURVIVAL|INFECTIVITY|NATURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88942,"idioma_id":4,"titulo":"Spermatogenesis is seasonal in the large hairy armadillo Chaetophractus villosus (Dasypodidae, Xenarthra, Mammalia).","resumen":"Very little is known about the distinct reproductive biology of armadillos. Very few studies have investigated  armadillo spermatogenesis, with data available only for Euphractus sexcinctus and Dasypus novemcinctus. In the present  study, we analysed male germ cell differentiation in the large hairy armadillo Chaetophractus villosus throughout the year,  describing a cycle of the seminiferous epithelium made of eight different stages. Evaluation of the testis\/body mass ratio,  analysis of the architecture of the seminiferous epithelium and the frequency of defective seminiferous tubules allowed  identification of a temporal interruption of spermatogenesis during the period between mid-May to July (mid\u2013end autumn)  in correlation with very low testosterone levels. Overall, these results suggest that spermatogenesis is seasonal in  C. villosus.","palabras_clave":"GERM CELLS|REPRODUCTION|SEMINIFEROUS EPITHELIUM|SERTOLI CELLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88943,"idioma_id":4,"titulo":"Babesia: a world emerging","resumen":"Babesia are tick-transmitted hemoprotozooans that infect mammals and birds, and which are acknowledged for their major impact on farm and pet animal health and associated economic costs worldwide. Additionally, Babesia infections of wildlife can be fatal if associated with stressful management practices; and human babesiosis, also transmitted by blood transfusion, is an increasing public-health concern. Due to the huge diversity of species reported to serve as Babesia hosts, all vertebrates might be potential carriers, as long as they are adequate hosts for Babesia-vector ticks. We here provide a comprehensive overviewof the most relevant Babesia species, and a discussion of the classical taxonomic criteria. Babesia, Cytauxzoon and Theileria parasites are closely related and collectively referred to as piroplasmids. A possible scenario for the history of piroplasmids is presented in the context of recent findings, and its implications for future research avenues are outlined. Phylogenetic trees of all available 18S rRNA and hsp70 genes were generated, based on which we present a thoroughly revised molecular classification, comprising five monophyletic Babesia lineages, one Cytauxzoon clade, and one Theileria clade. Updated 18S rRNA and beta-tubulin gene trees of the B. microti isolates agree with those previously reported. To reconcile estimates of the origin of piroplasmids and ticks (300 Ma, respectively), and mammalian radiation (60 Ma), we hypothesize that the dixenous piroplasmid life cycle evolved with the origin of ticks. Thus, the observed time gap between tick origin and mammalian radiation indicates the existence of hitherto unknown piroplasmid lineages and\/or species in extant vertebrate taxa, including reptiles and possibly amphibians. The development and current status of the molecular taxonomy of Babesia, with emphasis on human-infecting species, is discussed. Finally, recent results from population genetic studies of Babesia parasites, and their implications for the development of pathogenicity, drug resistance and vaccines, are summarized.","palabras_clave":"piroplasmids|molecular phylogeny|evolution|molecular taxonomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88944,"idioma_id":4,"titulo":"Regulation of plasma membrane Ca2+-ATPase activity by acetylated tubulin: influence of the lipid environment","resumen":"We demonstrated previously that acetylated tubulin inhibits plasma membrane Ca2+-ATPase (PMCA) activity in plasma membrane vesicles (PMVs) of rat brain through a reversible interaction. Dissociation of the PMCA\/tubulin complex leads to restoration of ATPase activity. We now report that, when the enzyme is reconstituted in phosphatidylcholine vesicles containing acidic or neutral lipids, tubulin not only loses its  inhibitory effect but is capable of activating PMCA. This alteration of the PMCA-inhibitory effect of tubulin was dependent on concentrations of both lipids and tubulin. Tubulin (300 &#956;g\/ml) in combination with acidic lipids at concentrations >10%, increased PMCA activity up to 27-fold. The neutral lipid diacylglycerol (DAG), in combination with 50 &#956;g\/ ml tubulin, increased PMCA activity > 12-fold, whereas tubulin alone at high concentration (&#8805;300 &#956;g\/ml) produced only 80% increase. When DAG was generated in situ by phospholipase C incubation of PMVs pre-treated with exogenous tubulin, the inhibitory effect of tubulin on PMCA activity (ATP hydrolysis, and Ca2+ transport within vesicles) was reversed. These findings indicate that PMCA is activated independently of surrounding lipid composition at low tubulin concentrations (<50 &#956;g\/ml), whereas PMCA is activated mainly by reconstitution in acidic lipids at high tubulin concentrations. Regulation of PMCA activity by tubulin is thus dependent on both membrane lipid composition and tubulin concentration.","palabras_clave":"PMCA|Tubulin|Lipids|Memebranes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88945,"idioma_id":4,"titulo":"Involvement of membrane tubulin in erythrocyte deformability and blood pressure","resumen":"OBJECTIVE:  To test the hypothesis that erythrocyte deformability is influenced by changes in the content of membrane tubulin (Mem-tub).  METHODS AND RESULTS:  Human erythrocytes contain tubulin distributed in three pools (membrane, sedimentable, soluble). Erythrocytes from hypertensive humans have a higher proportion of Mem-tub. Increased Mem-tub content in hypertensive patients was correlated with decreased erythrocyte deformability. Treatment of erythrocytes from normotensive individuals with taxol increased Mem-tub content and reduced deformability, whereas treatment of hypertensive patients erythrocytes with nocodazole had the opposite effect. In-vivo experiments with rats were performed to examine the possible relationship between Mem-tub content, erythrocyte deformability, and blood pressure. Spontaneously hypertensive rats (SHRs) showed lower erythrocyte deformability than normotensive Wistar rats. During the development of hypertension in SHR, tubulin in erythrocytes is translocated to the membrane, and this process is correlated with decreased deformability. In-vivo treatment (intraperitoneal injection) of SHR with nocodazole decreased Mem-tub content, increased erythrocyte deformability, and decreased blood pressure, whereas treatment of Wistar rats with taxol had the opposite effects.  CONCLUSION:  These findings indicate that increased Mem-tub content contributes to reduced erythrocyte deformability in hypertensive animals.","palabras_clave":"Blood pressure|Deformability|Human erythrocytes|membrane"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88946,"idioma_id":5,"titulo":"Espacios particulares de acumulación en relación a la megaminería metalífera a cielo abierta","resumen":"El caso de la mega \u2013 minería metalífera a cielo abierto se establece en nuestros tiempos como un caso paradigmático en diversos sentidos. En primer lugar, se constituye como una de las múltiples manifestaciones de un sistema productivo que se establece con diversas particularidades. En segundo lugar, expresa las formas imperantes de apropiación de la naturaleza en el actual sistema capitalista. En tercer lugar, muestra un movimiento del capital que en nuestro tiempo articula diversos espacios y territorios de forma particular, produciéndose territorialidades particulares que se establecen como uno de los principales ejes de conflicto generados en torno a dicha actividad. Dicho conflicto se constituye a partir de un determinado sentido que adopta el flujo de capital y materia presentes en un espacio de acumulación particular, que será caracterizado como localizándose en los límites del sistema capitalista. Finalmente, las características y dimensiones de esta actividad generan una alteración en la forma de organización social del trabajo, lo cual se establece como otro de los ejes conflictivos de la problemática.  La yuxtaposicion de todas estas dimensiones, generan espacio de acumulación particulares en el que persiste una 'situacion de frontera'. Por un lado, se concibe que estos espacios de acumulacion se encuentran en los límites del sistema capitalista por una determinada ecuacion y el sentido de circulacion entre los flujos de capitales y de materia. Por otro lado, porque se establecen una situacion en el que existe una lucha por las diferentes formas de concebir la articulacion de los espacios locales al sistema productivo en general.","palabras_clave":"Mega - mineria metalifer a cielo abierto|Acumulacion|Territorio |Frontera"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88947,"idioma_id":5,"titulo":"'A propósito del uso político del aparato estatal y la construcción de partidos políticos en la Argentina. Reflexiones sobre el peronismo en clave comparada: Corrientes y Santa Fe, 1946 - 1949.'","resumen":"El artículo tiene por objeto abordar -desde una perspectiva comparativa- la impronta que adquiere durante el peronismo la relación entre provincia y nación en dos escenarios regionales del litoral argentino: el de la provincia de Corrientes y de Santa Fe en el período 1946- 1949. Más específicamente, el análisis se centra en una de las dimensiones de esta relación: la dinámica de la esfera política (la organización del partido peronista, las relaciones gobierno- oposición, los actores, los ámbitos y las vías de participación) buscando avanzar hacia el estudio de la intrincada relación que se establece en el período entre política y estatalidad. El recorte temporal seleccionado presenta elementos de suma relevancia para el tema, puesto que, si bien la conflictividad en los vínculos nación\/provincia no es un fenómeno inédito en la construcción del estado argentino, durante el régimen peronista toma nuevos fundamentos que tienden a intensificar la tendencia a la centralización en el marco de una profunda crisis y mutación del sistema de partidos.La revista de la SAAP se encuentra indexada en LATINDEX","palabras_clave":"PERONISMO|RELACIONES NACIÓN\/PROVINCIA|CORRIENTES|SANTA FE|HISTORIA POLÍTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88948,"idioma_id":5,"titulo":"Variabilidad espacial de atributos químicos y físicos en un suelo de la Pampa Llana santafesina","resumen":"Los procesos y atributos que influyen sobre el desempeño de los cultivos varían en el espacio y tiempo. Su magnitud y estructuraespacial es específica para cada lote y su cuantificación es necesaria para la aplicación del manejo sitio-específico de cultivos (MSEC).Nuestro objetivo fue examinar la variabilidad espacial intra-lote de atributos químicos y físicos del horizonte superficial de unArgiudol típico del centro de Santa Fe para la implementación del MSEC. En una parcela de 475 x 100 m se tomaron 60 muestrasdistribuidas en 3 transectas de 20 puntos separados cada 25 m y 50 m entre transecta. En cada muestra perturbada (0-20 cm) sedeterminó N de nitratos (N-NO3), C orgánico total (COT), N total (Nt); P extractable (P), arena, arcilla, reacción del suelo (pH). Ladensidad aparente del suelo (Ds) se determinó a partir de muestras no perturbadas de las profundidades 0-10 y 10-20 cm. Se calcularonestadísticas descriptivas y se analizó la dependencia espacial de los atributos mediante variogramas empíricos y sus límites obtenidospor permutación (envelopes). Los coeficientes de variación (CV) para COT, Nt, Arena, Arcilla, Ds 0-10, Ds 10-20 y pH fueron bajos(CV < 15%) mientras que para P y N-NO3 fueron moderados (15 < CV < 35%). La dependencia espacial del N-NO3 fue moderadacon un rango de 96 m, mientras que el resto de los atributos no presentó autocorrelación producto de la variación que ocurrea distancias menores a la utilizada en el muestreo. En este estudio no fue posible modelar la distribución espacial de los atributosni obtener mapas de la condición de suelo confiables que permitan orientar el uso de MSEC debido a la escasa variabilidad y ausenciade estructura espacial de las propiedades del suelo evaluadas.","palabras_clave":"ARGIUDOLES|GEOESTADÍSTICA|MANEJO SITIO-ESPECÍFICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88949,"idioma_id":4,"titulo":"IL-12 and GM-CSF in DNA\/MVA immunizations against HIV-1 CRF12_BF Nef induced T- cell responses with an enhanced magnitude, breadth and quality","resumen":"Abstract  In Argentina, the HIV epidemic is characterized by the co-circulation of subtype B and BF recombinant viral variants. Nef is  an HIV protein highly variable among subtypes, making it a good tool to study the impact of HIV variability in the vaccine  design setting. We have previously reported a specific cellular response against NefBF with low cross-reactivity to NefB in  mice. The aim of this work was to analyze whether the co-administration of IL-12 and GM-CSF, using DNA and MVA vaccine  vectors, could improve the final cellular response induced. Mice received three DNA priming doses of a plasmid that express  NefBF plus DNAs expressing IL-12 and\/or GM-CSF. Afterwards, all the groups were boosted with a MVAnefBF dose. The  highest increase in the magnitude of the NefBF response, compared to that induced in the control was found in the IL-12  group. Importantly, a response with higher breadth was detected in groups which received IL-12 or GM-CSF, evidenced as  an increased frequency of recognition of homologous (BF) and heterologous (B) Nef peptides, as well as a higher number of  other Nef peptide pools representing different viral subtypes. However, these improvements were lost when both DNA  cytokines were simultaneously administered, as the response was focused against the immunodominant peptide with a  detrimental response towards subdominant epitopes. The pattern of cytokines secreted and the specific-T-cell proliferative  capacity were improved in IL-12 and IL-12+GM-CSF groups. Importantly IL-12 generated a significant higher T-cell avidity  against a B heterologous peptide. This study indicates that the incorporation of DNA expressing IL-12 in DNA\/MVA  schemes produced the best results in terms of improvements of T-cell-response key properties such as breadth, crossreactivity  and quality (avidity and pattern of cytokines secreted). These relevant results contribute to the design of strategies  aimed to induce T-cell responses against HIV antigens with higher quality.","palabras_clave":"MVA|Adjuvants|Immune response|HIV"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88950,"idioma_id":4,"titulo":"Genetic and Functional Analysis of HIV Type 1 nef Gene Derived from Long-Term Nonprogressor Children: Association of Attenuated Variants with Slow Progression to Pediatric AIDS","resumen":"      Among persons infected by HIV-1, the rate of progression to AIDS is multifactorial being affected by host and viral factors, including the HIV-encoded negative factor (Nef). Our aim was to define whether variations in the nef gene as well as its functions may be associated with slower HIV disease course in infected children. The proviral HIV-1 nef gene was cloned, sequenced, and compared in children with contrasting disease course: 10 long-term nonprogressors (LTNP) and six rapid progressor (RP). The CD4 and MHC-I down-modulation ability of nef alleles derived from LTNP and RP children was analyzed. We observed that only one of our 10 LTNP had a protective genetic background, and out of them, 40% had defective nef genes, carrying substitutions at the (AWLEAQ56?61) and the (Rxx22?24) domains, and that those alleles were unable of down-regulate CD4 and MHC-I. The emergence or presence of Nef L58V substitution was associated with viral attenuation, indicated by a reduction in HIV viral loads, a persistent preservation of CD4+ T cell counts, and lack of AIDS-related symptoms. Our results demonstrate that HIV-1 perinatally infected children carrying functionally defective nef HIV-1 strains have prolonged asymptomatic phases without therapy, suggesting a relevant role of CD4 and MHC-I downmodulation Nef domains on in vivo HIV-1 pathogenesis and pediatric immunodeficiency outcome. nef gene as well as its functions may be associated with slower HIV disease course in infected children. The proviral HIV-1 nef gene was cloned, sequenced, and compared in children with contrasting disease course: 10 long-term nonprogressors (LTNP) and six rapid progressor (RP). The CD4 and MHC-I down-modulation ability of nef alleles derived from LTNP and RP children was analyzed. We observed that only one of our 10 LTNP had a protective genetic background, and out of them, 40% had defective nef genes, carrying substitutions at the (AWLEAQ56?61) and the (Rxx22?24) domains, and that those alleles were unable of down-regulate CD4 and MHC-I. The emergence or presence of Nef L58V substitution was associated with viral attenuation, indicated by a reduction in HIV viral loads, a persistent preservation of CD4+ T cell counts, and lack of AIDS-related symptoms. Our results demonstrate that HIV-1 perinatally infected children carrying functionally defective nef HIV-1 strains have prolonged asymptomatic phases without therapy, suggesting a relevant role of CD4 and MHC-I downmodulation Nef domains on in vivo HIV-1 pathogenesis and pediatric immunodeficiency outcome. ","palabras_clave":"HIV pediatrics|evolution|nef"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88951,"idioma_id":4,"titulo":"Adaptability to climate change in forestry species: drought effects on growth and wood anatomy of ponderosa pines growing at different competition levels","resumen":"More stressful conditions are expected due to climatic change in several regions, including Patagonia, South-America. In this region, there are no studies about the impact of severe drought events on growth and wood characteristics of the most planted forestry species, Pinus ponderosa (Doug. ex-Laws). The objective of this study was to quantify the effect of a severe drought event on annual stem growth and functional wood anatomy of pines growing at different plantation densities aiming to understand how management practices can help to increase their adaptability to climate change. Growth magnitude and period, specific hydraulic conductivity, and anatomical traits (early- and latewood proportion, lumen diameter, cell-wall thickness, tracheid length and bordered pit dimensions) were measured in the ring 2008-2009, which was formed during drought conditions. This drought event decreased annual stem growth by 30-38% and 58-65% respect to previous mean growth, in open vs. closed stand trees, respectively, indicating a higher sensitivity of the latter, which is opposite to reports from the same species growing in managed native forests in USA. Some wood anatomical variables did differ in more water stressed trees (lower cell wall thickness of earlywood cells and higher proportion of small-lumen cells in latewood), which in turn did not affect wood function (hydraulic conductivity and resistance to implosion). Other anatomical variables (tracheid length, pit dimensions, early- and latewood proportion, lumen diameter of earlywood cells) did not differ between tree sizes and plantation density. The results suggest that severe drought affects differentially the amount but not the function and quality of formed wood in ponderosa pine growing at different competition levels.","palabras_clave":"FUNCTIONAL WOOD ANATOMY|PINUS PONDEROSA|DROUGHT RESISTANCE|STAND DENSITY EFFECTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88952,"idioma_id":4,"titulo":"ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane\/substrate interface","resumen":"PTP1B is an endoplasmic reticulum (ER) anchored enzyme whose access to substrates is partly dependent on the ER distribution and dynamics. One of these substrates, the protein tyrosine kinase Src, has been found in the cytosol, endosomes, and plasma membrane. Here we analyzed where PTP1B and Src physically interact in intact cells, by bimolecular fluorescence complementation (BiFC) in combination with temporal and high resolution microscopy. We also determined the structural basis of this interaction. We found that BiFC signal is displayed as puncta scattered throughout the ER network, a feature that was enhanced when the substrate trapping mutant PTP1B-D181A was used. Time-lapse and co-localization analyses revealed that BiFC puncta did not correspond to vesicular carriers; instead they localized at the tip of dynamic ER tubules. BiFC puncta were retained in ventral membrane preparations after cell unroofing and were also detected within the evanescent field of total internal reflection fluorescent microscopy (TIRFM) associated to the ventral membranes of whole cells. Furthermore, BiFC puncta often colocalized with dark spots seen by surface reflection interference contrast (SRIC). Removal of Src myristoylation and polybasic motifs abolished BiFC. In addition, PTP1B active site and negative regulatory tyrosine 529 on Src were primary determinants of BiFC occurrence, although the SH3 binding motif on PTP1B also played a role. Our results suggest that ER-bound PTP1B dynamically interacts with the negative regulatory site at the C-terminus of Src at random puncta in the plasma membrane\/substrate interface, likely leading to Src activation and recruitment to adhesion complexes. We postulate that this functional ER\/plasma membrane crosstalk could apply to a wide array of protein partners, opening an exciting field of research. ","palabras_clave":"PTP1B"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88953,"idioma_id":4,"titulo":"Glyphosate-Induced Structural Variations in Commelina erecta L. (Commelinaceae)","resumen":"The purpose of this study was to analyze the structural variations of Commelina erecta, a glyphosate-tolerant weed, produced by this herbicide. Regrowth shoots (vegetative cloning axes) and seedlings and two glyphosate concentrations: 900 and 1800 grams of acid equivalent per hectare (g a.e. ha&#8722;1) were used. The following variations were observed: foliar shape and size changes, changes in the length of internodes, variations in the quantity of inflorescences, low seed production, and differences in the number of branches. After treatment, different phenotypic responses were observed as a result of differential sensitivity to glyphosate. Most of the vegetatively-propagated plants treated with 900 g a.e. ha&#8722;1 revealed the same morphological structure as that of controls (i.e. three clearly identifiable zones: a basal or branching zone, a middle zone where branch production is inhibited, and an apical zone where only floral branches are produced). By contrast, the 900 g a.e. ha&#8722;1 treated seedlings and the 1800 g a.e. ha&#8722;1 treated regrowth shoots and seedlings showed two phenotypic responses, exhibiting differences in the quantity and location of branches and in the survival time of axes. The main variation is seen in branch production in the region that is usually inhibited. The different phenotypic responses and morphological changes suggest that C. erecta shows a very high intraspecific variability, which allows it to survive and thrive even in environments with intensive glyphosate application. These results underscore the need to solve the problem of tolerant weeds by means of an integrated approach including alternative management practices grounded on knowledge of the species and their behavior.","palabras_clave":"Monocot|Tolerant weed|Morphology|Herbicide|Symptoms"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88954,"idioma_id":4,"titulo":"Bimagnetic CoO core\/ CoFe2O4 shell nanoparticles: Synthesis and magnetic properties","resumen":"In this work we report on the synthesis, the microstructuralcharacterization, and the magnetic properties of &#8764;7 nmbimagnetic core\/shell nanoparticles prepared by seed-mediated growthhigh temperature decomposition of organometallic precursor. Thenanoparticles are formed by an antiferromagnetic CoO core coated with ferromagnetic CoFe2O4 shell of 2&#8722;3 nm of thickness. XRD and electron diffraction patterns show the reflections of the structure of the CoFe2O4 and CoO phases and Dark- and Bright-field TEM images provideevidence of the core&#8722;shell morphology of the system. Magnetic measurements show that the system presents a remarkably large coercivity and high squareness (at 5 K, HC = 27.8 kOe and Mr\/MS = 0.79), compared to CoFe2O4 single phase nanoparticles of comparable size. The enhancement of the effective anisotropy is attributed to the surface and interface exchange coupling effects.","palabras_clave":"bimagnetic nanoparticles|CoO\/CoFe2O4 nanoparticles|interface exchange coupling|magnetic anisotropy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88955,"idioma_id":4,"titulo":"Magnetic hardness features and loop shift in nanostructured CuO","resumen":"Nanostructures of cupric oxide (CuO) obtained by ball milling show drastic changes in itsmagnetic behavior that cannot be only associated to a size effect. While sample of average size D ~ 29 nm presents a magnetic behavior that resembles that of bulk material with a Neel&nbsp;temperature of 195 K, another sample with D ~ 24 nm displays a departure from the magnetic features typical of bulk CuO and has magnetic hardness characteristics at low temperatures. Both samples show irreversibility above room temperature and shifts in their hysteresis loops along magnetization and field axis when field cooled in a HFC=50 kOe to 10 K. At this temperature, an apparent exchange bias like field, 'HEB', 0.17 and 1.06 kOe were estimated for 29 and 24 nm CuO samples, respectively. Magnetic behavior differences observed in samples subjected to distinct milling times are explained as due to a proposed model for milled CuO consisting of a multilayer configuration where interfaces comprise uneven structural disorder and oxygen deficiencies, which generate a peculiar antiferromagnetic\/ferromagnetic interface configuration.","palabras_clave":"CuO|nanostructure|magnetims"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88956,"idioma_id":4,"titulo":"Origin of magnetic anisotropy in ZnO\/CoFe2O4 and CoO\/CoFe2O4 core\/shell nanoparticle systems","resumen":"ZnO-core\/CoFe2O4-shell nanoparticles of 7.4 nm average size have been synthesized and their magnetic properties have been compared to those of CoO-core\/CoFe2O4-shell nanoparticles with similar morphology. The coercive field values are much lower than those for CoO\/CoFe2O4 nanoparticles (e.g. at 5 K : Hc = 7.8 kOe for ZnO\/CoFe2O4; Hc = 27.8 kOe for CoO\/CoFe2O4). The nature of the coercive field values is explained by a phenomenological model for the free energy of a non-magnetic core, or an antiferromagnetic core, encapsulated by a hard ferrimagnetic shell. ","palabras_clave":"MAGNETIC ANISOTROPY|CORE\/SHELL NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88957,"idioma_id":4,"titulo":"Life history of Tanais dulongii (Tanaidacea: Tanaidae) in an intertidal flat in the southwestern Atlantic","resumen":"We studied the life history, reproductive biology and spatial distribution of Tanais dulongii on an intertidal flat near Mar del Plata,  Argentina. The animals were obtained by systematic sampling in three intertidal zones (high, mid and low), from October 2008 to  September 2009. The population density was low during most of spring and summer, increased during autumn and reached its maximum  values at the end of this season (35 000 individuals\/m2); a second, but lower, density peak occurred at the end of winter (15 000  individuals\/m2). Male density remained below 1000 individuals\/m2 during most of the year in the three zones, although in September  it was higher than 1800 individuals\/m2 in the high and mid intertidal zones. Female and juvenile density was below 5000 individuals\/m2  in spring and summer, with little variation between areas, but it differed among areas during autumn and winter, when both groups reached  their maximum densities (20 000-40 000 individuals\/m2) in the low and mid intertidal zones. Ovigerous females were always present; their  maximum occurred in spring and summer but earlier in the low and later in the high intertidal zone. Recruitment was higher in autumn  and early winter. The sex ratio was strongly female biased (0.08 ± 0.01). Individual life time was estimated to be 8-9 months and females  developed through more instars than males. This study suggests that the different environmental conditions that T. dulongii faced in the 3  intertidal zones caused an important effect on the population dynamics","palabras_clave":"intertidal, life history|reproduction|spatial and temporal variation|Tanais dulongii"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88958,"idioma_id":5,"titulo":"Supervivencia y capacidad infectiva de larvas criopreservadas de nematodes trichostrongylideos","resumen":"El desarrollo de una técnica de criopreservación de larvas infectantes (L3) ha permitido mantenernematodes gastrointestinales en laboratorio por prolongados periodos. El objetivo de este trabajofue determinar la tasa de supervivencia y la capacidad infectiva post-descongelado de L3 de nematodes gastrointestinales. Para ello se utilizaron L3 denominadas en base a su origen como Ayacucho y Balcarce, las que fueron desenvainadas y posteriormente congeladas en nitrógeno líquido a \u2013196ºC. Transcurrido un período de 3 y 7 meses, las larvas fueron descongeladas calculándose la tasa de supervivencia (%) considerando la movilidad como factor discriminante&nbsp;vivo\/muerto. La capacidad infectiva se determinó en 6 ovinos, inoculados vía oral con 18.500 L3criopreservadas. El desarrollo de los nematodes se comprobó a través de la excreción de huevos en heces de los animales inoculados. La supervivencia post-descongelado varió entre 31-70% a los 3 meses y entre 68-72% a los 7 meses. Los animales comenzaron a excretar huevos de nematodes a los 21 días post-inoculación, independientemente del tiempo de congelado y del origen de las larvas. Se destacan las ventajas de la técnica de criopreservación de nematodes como una contribución significativa a la investigación en parasitología veterinaria.","palabras_clave":"CRIOPRESERVACIÓN|HAEMONCHUS|OVINOS|DESCONGELADO|INFECCIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88959,"idioma_id":4,"titulo":"The phylogenetic relationships of four monospecific caesalpinioids (Leguminosae) endemic to southern South America","resumen":"Abstract:  Balsamocarpon, Lophocarpinia, Stenodrepanum and Zuccagnia are monospecific endemic genera from arid or saline areas of southern South America (Argentina, Paraguay, Chile). Several molecular studies have explored relationships within Caesalpinioideae and the Caesalpinia group but, until now, Stenodrepanum has not been included, Lophocarpinia has been poorly represented and these four South American taxa have not been analyzed together. In order to resolve their evolutionary relationships, a phylogenetic analysis of the plastid trnL-F intron and spacer region that included a broad range of published sequences from Caesalpinieae was used. Combined trnL-F, matK\/trnK and morphological data were analysed for a subset of taxa. Stenodrepanum, Balsamocarpon and Zuccagnia formed a monophyletic group with the amphitropical American genus Hoffmannseggia. The clade shares a synapomorphy of sepal persistence in the fruit. Lophocarpinia is shown also to belong to the Caesalpinia informal generic group as traditionally proposed, and grouped with Haematoxylum with which it shares the presence of branches and inflorescences crowded on short shoots and spines derived from branches. As a contribution to the understanding of the Caesalpinia group, phylogenetic hypotheses were used to discuss evolution of selected characters within the group.","palabras_clave":"BALSAMOCARPON|LOPHOCARPINIA|MATK\/TRNK|MORPHOLOGY|SOUTH AMERICA|STENODREPANUM| TRNL-F|ZUCCAGNIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88960,"idioma_id":4,"titulo":"Biodiversity characterization of cellulolytic bacteria present on native Chaco soil by comparison of ribosomal DNA sequences","resumen":"Sequence analysis of the 16S ribosomal RNA gene was used to study bacterial diversity of a pristine forest soil and of two cultures of the same soil enriched with cellulolytic bacteria. Our analysis revealed high bacterial diversity in the native soil sample, evidencing at least 10 phyla, in which Actinobacteria, Proteobacteria and Acidobacteria accounted for more than 76% of all sequences. In both enriched samples, members of Proteobacteria were the most frequently represented. The majority of bacterial genera in both enriched samples were identified as Brevundimonas and Caulobacter, but members of Devosia, Sphingomonas, Variovorax, Acidovorax, Pseudomonas, Xanthomonas, Stenotrophomonas, Achromobacter and Delftia were also found. In addition, it was possible to identify cellulolytic taxa such as Acidothermus, Micromonospora, Streptomyces, Paenibacillus and Pseudomonas, which indicates that this ecosystem could be an attractive source for study of novel enzymes for cellulose degradation.","palabras_clave":"metagenomics|native soils|ribosomal RNA gene|cellulolytic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88961,"idioma_id":4,"titulo":"Some issues on the design of a solar vehicle based on hybrid energy system","resumen":"The conception and assembly of an experimental Hybrid Electric Vehicle based on the combination of human energy contribution and photovoltaic solar energy is presented in this manuscript. The vehicle has a battery for storing the energy provided by both systems. The application\u2019s aim is to achieve the lowest possible energy consumption for the vehicle\u2019s movement, with photovoltaic modules as the main electricity source. The development of the solar vehicle was motivated by a Latin-American solar vehicles race about 1000km across the Atacama Desert in Chile, South America. The main constructive aspects, energy issues and experimental results are presented.","palabras_clave":"Hybrid Electric Vehicle"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88962,"idioma_id":4,"titulo":"Immunogenicity of a Bovine Herpes Virus I peptide expressed in tandem copies in attenuated Salmonella","resumen":"Foot and Mouth Disease (FMD) is an acute disease of cloven-hoofed species. We studied the protection and early immune response induced in the murine model by vaccines formulated with inactivated virus and two different adjuvants. The presence of IMS12802PR or ISA206VG adjuvants yielded protection against viral challenge at early times post vaccination and induced FMDV-specific, but non neutralizing, antibody titers. In vivo macrophage depletion in vaccinated mice severely decreased the protection levels after virus challenge, indicating a  central role of this cell population in the response elicited by the vaccines. Accordingly, opsonophagocytosis of FITC-labelled virus was augmented in 802-FMDVi and 206-FMDVi vaccinated mice. These results demonstrate the ability of the studied adjuvants to enhance the protective responses of these inactivated vaccines without the increase in seroneutralizing antibodies and the main role of opsonization and phagocytosis in the early protective immune responses against  FMD infection in the murine model.","palabras_clave":"SALMONELLA|VACCINE|EPITOPE|BoHV-1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88963,"idioma_id":4,"titulo":"Isolation and characterization of bovine parainfluenza virus type 3 from water buffaloes (Bubalus bubalis) in Argentina","resumen":"Background: Parainfluenza virus type 3 (PIV3) was isolated from dairy buffaloes (Bubalus bubalis) naturally affectedwith respiratory and reproductive clinical conditions.Results: Examination of nasal and vaginal swabs collected from 12 diseased buffaloes led to the isolation of threeparamyxovirus isolates from two animals. Antigenic, morphological and biological characteristics of these threeisolates were essentially similar to those of members of the Paramyxoviridae family. Antigenic analysis by directimmunofluorescence and cross neutralization test placed these isolates together with bovine parainfluenza virustype 3 (BPIV3). Nucleotide and amino acid phylogenetic analysis of partial matrix gene sequences of the buffaloisolates and six field BPIV3 isolates from bovines in Argentina were studied. Buffalo isolates were similar togenotype B (BPIV3b) while the six BPIV3 isolates were similar to genotypes A (BPIV3a) and C (BPIV3c).Conclusions: This is the first characterization of BPIV3 in water buffalo.According to the samples analyzed, in Argentina, the genotype B was found in buffalo and the genotypes A and Cwere found in cattle.","palabras_clave":"parainfluenza virus|PI3|BPIV3"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88964,"idioma_id":5,"titulo":"Avances en el desarrollo    de vacunas contra la neosporosis bovina","resumen":"La neosporosis es una enfermedad que ocasiona abortos en bovinos y está causada por un protozoo intracelular obligado denominado Neospora caninum. Las graves pérdidas económicas que provoca en los sistemas de producción de bovinos justifica la necesidad de avanzar en el desarrollo de vacunas. La resistencia a parásitos Apicomplexa está asociada a una respuesta inmune T helper 1 mediada por linfocitos T CD4 citotóxicos y a la producción de interferón-gamma, interleuquina-12, factor de necrosis tumoral e inmunoglobulina G2. La disminución de la transmisión vertical en las sucesivas preñeces y el bajo nivel de repetición de abortos en animales infectados sugieren la existencia de mecanismos inmunitarios de protección. Hasta el momento se conoce que la inoculación pre-servicio con taquizoítos vivos protege contra la infección y el aborto. Los antecedentes de desarrollo de vacunas vivas contra otros protozoos estimulan a los investigadores a continuar en la búsqueda de una vacuna de este tipo contra N. caninum de buena eficacia. Por otra parte, una vacuna inactivada, aun con una baja eficacia, es útil en la prevención del aborto en aquellos establecimientos donde la enfermedad es epizoótica. Una vacuna contra la neosporosis debería evitar el aborto, la transmisión transplacental y la persistencia de la infección. Este trabajo menciona los diversos tipos de vacunas que han sido evaluados hasta el momento, incluyendo inmunógenos inactivos, taquizoítos vivos, antígenos recombinantes y vacunas en vectores.","palabras_clave":"Neospora caninum|bovinos|aborto|vacuna"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88965,"idioma_id":4,"titulo":"Effects of stratocumulus, cumulus, and cirrus clouds on the UV-B diffuse to global ratio: Experimental and modeling results","resumen":"Broadband measurements of global and diffuse UV-B irradiance (280\u2013315&nbsp;nm) together with modeled and measured diffuse to global ratios (DGR) have been used to characterize the influence of different types of clouds on irradiance at the surface. Measurements were carried out during 2000\u20132001 in Córdoba City, Argentina. The Tropospheric Ultraviolet Visible (TUV) model was used to analyze the behavior of the modeled DGRs for different cloud optical depths and at different altitudes and solar zenith angles (SZA). Different cloud altitudes were also tested, although only the results for a cloud placed at 1.5\u20132.5&nbsp;km of altitude are shown. A total of 16 day with stratocumulus, 12 with cumulus, and 16 with cirrus have been studied and compared among them and also against 21 clear sky days. Different behaviors were clearly detected and also differentiated through the analysis of the averages and the standard deviations of the DGRs: 1.02±0.06 for stratocumulus, 0.74±0.18 for cumulus, 0.63±0.12 for cirrus, and 0.60±0.13 for the clear sky days, respectively. Stratocumulus clouds showed a low variability in the DGR values, which were concentrated close to one at all SZAs. DGR values for cumulus clouds presented a large variability at all SZAs, mostly associated with the different optical depths. Finally, the closeness between the DGR values for cirrus clouds and the DGR values for clear days showed that these clouds generally do not strongly affect the UV-B irradiance at the surface at any SZA. In the opposite side, stratocumulus clouds were identified as those with the largest effects, at all SZAs, on the UV-B irradiance at the surface.","palabras_clave":"TIPOS DE NUBES|DGR|UV-B IRRADIANCE|RADIATIVE TRANSFER MODEL|CLOUD OPTICAL PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88966,"idioma_id":4,"titulo":"Heat Shock Proteins (HSPs) based anti-cancer vaccines","resumen":"The importance of HSPs themselves in antigen presentation and cross-presentation remains controversial. Most studies agree that as part of their molecular chaperone function, HSPs can bind and present tumor associated antigens to professional antigen presenting cells through MHC class I and class II molecules, leading to the activation of anti-tumor CD8+ and CD4+ T cells. The regulation of the innate and adaptive immune responses by HSPs is still a matter of intense research. HSPs are seen as important anticancer vaccine adjuvants. They are used through different delivery systems: HSPs\/antibodies, peptide\/protein-HSP complexes, tumor antigen\/HSP gene fusion, viral peptides\/HSP complexes or gene fusion, viral proteins\/bacterial HSP fusion. In preclinical models different administration routes, subcutaneous, intradermal, intramuscular or even peroral (under special conditions) can be used, and the animal toxicities are non-significant. The HSP-based vaccines can induce specific and non-specific cellular immune responses all of which are important to induce tumor rejection. In addition, the antibodies generated after vaccination are emerging as important protagonist in the antitumoral response. This response is significantly enhanced when the suppressive tumor microenvironment and the immune suppressing effector cells are blocked. Several clinical studies have been carried out and are ongoing, immunizing cancer patients with autologous tumor derived HSP-peptide complexes (HSPPCs). The most promising results have been observed in patients with melanoma and renal clear cell cancer without advanced disease. There are clinical trials with HSP-based anticancer vaccines other than with HSPPCs (including patients with non-Hodgkin lymphoma, high-grade transitional cell carcinoma of the bladder, high-grade cervical dysplasia, etc).","palabras_clave":"CANCER|HEAT SHOCK PROTEINS|IMMUNE SYSTEM|VACCINES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88967,"idioma_id":4,"titulo":"Dinuclear copper(II) complexes with valsartan. Synthesis, characterization and cytotoxicity","resumen":"Two novel dinuclear complexes involving the antihypertensive drug valsartan and copper(II) ion have been prepared in water and DMSO. The complex compositions were determined as: [Cu(vals)(H2O)3]2.6H2O and [Cu(vals)(H2O)2DMSO]2.2H2O. They were thoroughly characterized by elemental and thermal analysis, spectrophotometric titrations and UV\u2013visible, diffuse reflectance, FTIR, Raman and EPR spectroscopies. No effect of the ligand on two tested osteoblastic cell lines in culture (one normal MC3T3E1 and one tumoral UMR106) was observed in concentrations up to 100 &#956;M. Higher concentrations of Valsartan are required to induce cytotoxicity in both cell lines. The antiproliferative effect of the tested complex ([Cu(vals)(H2O)3]2.6H2O) in a dose\u2013response manner, was higher in the UMR106 osteoblastic cell line than that of the MC3T3E1 normal line at concentrations &#8805;100 &#956;M. Morphological alterations are in accordance with proliferative observations.","palabras_clave":"COPPER(II) DINUCLEAR COMPLEXES|ANTIHYPERTENSIVE DRUGS|VARSALTAN DERIVATIVES|IN VITRO CYTOTOXICITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88968,"idioma_id":4,"titulo":"Recent patents for detecting the species of origin in animal feedstuff, and raw and processed meat products","resumen":"The value of the traceability and labeling of food is attributable to two main aspects: health safety and\/or product or process certification. The identification of the species related to meat production is an important matter for economic, religious and health reasons. Many approaches and technologies have been used for species identification in animal feedstuff and food. The early methods for meat products identification include physical, anatomical, histological and chemical. Since 1970, a variety of methods were developed, these include electrophoresis (i.e. isoelectrofocusing), chromatography (i.e. HPLC), immunological techniques (i.e. ELISA), Nuclear Magnetic Resonance, Mass Spectrometry and PCR (DNA and RNA based methods). The recent patents on species detection in animal feedstuffs, raw meat and meat processed products, listed in this work, are mainly based on monoclonal antibodies and PCR, especially RT-PCR. The new developments under research are looking for more sensible, specific, less time consuming and quantitatively detection methods, which can be used in highly processed or heated treated meat food.","palabras_clave":"Contaminant|DNA|fraud|meat|processed|species identification"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88969,"idioma_id":4,"titulo":"Variation for Single Sequence Repeats (SSR) polymorphism in a tomato Second Cycle Hybrid (SCH) and its parents in respect to the uniform genotypes from which they were derived","resumen":"Forty nine SSR were applied to a tomato SCH and its parents, two Recombinat Inbred Lines (RIL18 and RIL1) derived from a cross among the cultivated Solanum lycopersicum cv. Caimanta (C) and the wild S. pimpinellifolium LA722 (P). These original genotypes together with the interspecific F1(CxP)had been previously characterized with the same SSR. In the first group of genotypes (RIL18, RIL19 and SCH), 41 SSR amplified. Just 26 of them were polymorphic, 22 being codominant (as expected for SSR) and 4 being dominant. In adittion, 10 of the polymorphic SSR amplified two bands (6 in RIL18 and 4 in RIL1), which is not expected in homozygous genotypes. Five of the 15 monomorphic SSR had also been monomorphic in the second group of genotypes: C, P and F1(CxP). The remaining 10 monomorphic SSR had been polymorphic in the second group and represent genomic regions fixed by artificial selection during the selfing generations that allowed obtaining the RILs. Also, 6 of the SSR showing two bands in the first group had been monomorphic in the second group, these results suggesting that chromosomal rearrangments ocurred during the selfing generations. Though a less levels of polymorphism was found in the first group in respect to the second one, an adequate number of SSR was selected to characterize the segregant generations of the SCH in order to validate QTLs detected in early generations derived from F1(CxP).","palabras_clave":"GENETIC RESOURCES|SECOND CYCLE HYBRID |MOLECULAR MARKERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88970,"idioma_id":4,"titulo":"Plasmonics Meets Far-Field Optical Nanoscopy","resumen":"Plasmonics and near-&#64257;eld optical nanoscopy both deal with expanding optics into the subwavelength regime. However, these two &#64257;elds have so far followed parallel paths of development and only recently have researchers started to explore combinations of their concepts with potential synergy. In this Perspective, we provide an up-to-date summary of the successful combinations reported and give insight into some new possibilities.","palabras_clave":"SUPERRESOLUTION|PLASMONICS|OPTICAL NANOSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88971,"idioma_id":4,"titulo":"Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines","resumen":"In this work two cytokines were used in combination with inactivated bacteria (bacterin) to test the bovine conjuctival immune response to the pathogen Moraxella bovis, the causative agent of Infectious bovine keratoconjunctivitis (IBK). Treatments using the bacterin vaccine combined with interleukin-2 and interferon-&#945; as adjuvants (Group A), the bacterin vaccine only (Group B), and controls without treatment (Group C), were applied by ocular spraying to evaluate the local immune response in the corneal structure of cattle experimentally infected with M. bovis. Six weeks after infection, 14 out of a total of 34 animals presented different corneal lesions; 9 corresponding to the control group C, 4 to the group B and only one to the group A. According to the clinical manifestations, a numeric score was calculated. Control animals presented the highest score value (12 points), followed by group B (7.5 points) and group A (1 point). These results suggest that the addition of cytokines to M. bovis treatments can reduce not only eye injuries caused by IBK but also the number of diseased animals.","palabras_clave":"infectious bovine keratoconjunctivitis|Moraxella bovis|cytokines"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88972,"idioma_id":4,"titulo":"Cationic amino acid uptake occurs in the flagellar pocket of Trypanosoma cruzi and constitutes a metabolic regulation mechanism","resumen":"Trypanosomatids´ amino acid permeases are key proteins in parasite metabolism since  they participate in the adaptation of parasites to different environments. Here, we  report that TcAAP3, a member of a Trypanosoma cruzi multigene family of permeases,  is a bona fide arginine transporter. Most of higher eukaryotic cells incorporate cationic  amino acids through a single transporter. In contrast, T. cruzi can recognize and  transport cationic amino acids by mono-specific permeases since, a 100-fold molar  excess of lysine could not affect the arginine transport in parasites that over-express  the arginine permease (TcAAP3 epimastigotes). In order to test if the permease activity  regulates downstream processes of the arginine metabolism, the expression of the  single T. cruzi enzyme that uses arginine as substrate, arginine kinase, was evaluated  in TcAAP3 epimastigotes. In this parasite model, intracellular arginine concentration  increases 4-folds and ATP level remains constant until cultures reach the stationary  phase of growth, when decrease about 6-folds respect to the controls. Interestingly,  Western Blot analysis demonstrated that arginine kinase is significantly downregulated  during the stationary phase of growth in TcAAP3 epimastigotes. This  decrease could represent a compensatory mechanism for the increase in ATP  consumption as a consequence of the displacement of the reaction equilibrium of  arginine kinase, when the intracellular arginine concentration augments and the  glucose from the medium is exhausted. Using immunofluorescence techniques we also  determined that TcAAP3 and the specific lysine transporter TcAAP7 co-localize in a  specialized region of the plasma membrane named flagellar pocket, staining a single  locus close to the flagellar pocket collar. Taken together these data suggest that  arginine transport is closely related to arginine metabolism and cell energy balance.  The clinical relevance of studying trypanosomatids´ permeases relies in the possibility  of using these molecules as a route of entry of therapeutic drugs.","palabras_clave":"Trypanosoma cruzi|Chagas Disease|Amino acid transport|Arginine transport"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88973,"idioma_id":4,"titulo":"New records of mosquito  species (Diptera: Culicidae)  from Neuquén and La Rioja  provinces, Argentina","resumen":"The presence of Aedes aegypti is reported beyond its current limit of distribution in Argentina, in the city of Neuquén, Neuquén Province. Ovitraps were placed to collect Ae. aegypti eggs between December 2009 and April 2010. The geographical distribution of Culex eduardoi, Psorophora ciliata and Ps. cingulata is extended with new records from two provinces.","palabras_clave":"Insect Vectors|Aedes aegypti|Culex eduardoi|Psorophora ciliata|Psorophora cingulata|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88974,"idioma_id":4,"titulo":"Bioremediation of an aged diesel oil-contaminated Antarctic soil: evaluation of the 'on site' biostimulation strategy using different nutrient sources","resumen":"Autores: Romina L. Dias, Lucas Ruberto, Susana C. Vázquez  Edgardo Hernández, Alfredo Lo Balbo, María T. Del Panno, & Walter P. Mac Cormack.  Título del trabajo: \u201CBioremediation of an aged diesel oil-contaminated Antarctic soil: evaluation of the 'on site' biostimulation strategy using different nutrient sources\u201D.  Nombre de la revista: International Biodeterioration & Biodegradation. 75, 96 -103 (2012).","palabras_clave":"BIOSTIMULATION|BIOREMEDIATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88975,"idioma_id":4,"titulo":"Acetohydroxyacid synthase (AHAS) in vivo assay for screening imidazolinone-resistance in sunflower (Helianthus annuus L.)","resumen":"The objective of this work was to evaluate the in vivo acetohydroxyacid synthase (AHAS) activity response to imidazolinones and its possible use as a selection method for evaluating AHAS inhibitor resistance. In vivo AHAS assay and the comparison of parameters from dose-response curves have been used as a valid tool for comparing sunflower lines and hybrids differing in imidazolinone resistance. The sunflower resistant genotypes evaluated here were 100-fold and 20-fold more resistant compared with the susceptible line for imazethapyr and imazapyr, respectively. This assay also allowed discrimination of homozygous from heterozygous genotypes for Imr1locus that codify for the catalytic subunit of AHAS. The in vivo AHAS assay described in this study was useful for the selection of sunflower genotypes differing in herbicide resistance and could be a useful tool when breeding for imidazolinone resistance in sunflower.","palabras_clave":"AHAS INHIBITORS|IN VIVO AHAS ACTIVITY|IMIDAZOLINONE|HELIANTHUS ANNUUS L"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88976,"idioma_id":4,"titulo":"Hydrogenation of Tetralin over Ir-Containing Mesoporous Catalysts","resumen":"A new series of catalysts based on noble metals have been prepared with the main aim of obtaining thiotolerant catalysts to be used in second-stage processes of mild hydrotreating. We studied the catalytic properties of 1 wt % Ir-containing mesoporous materials in the hydrogenation of tetralin to decalin, in the presence of 100 ppm of dibenzotiophene at 250 °C and 15 atm pressure of hydrogen, using a Parr reactor. Ir\/mesoporous materials were prepared by wetness impregnation, using iridium acetylacetonate as the source of Ir. The Ir\/SBA-3 catalyst synthesized by us had a high activity in tetralin hydrogenation under mild conditions. The experimental data were quantitatively represented by a modified Langmuir&#8722;Hinshelwood-type rate equation. The preliminary results reveal that these materials are promising catalyts for HDS\/HDN reactions.","palabras_clave":"Ir- SBA-3|Ir-MCM-41|HYDROGENATION|REACTION KINETIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88977,"idioma_id":5,"titulo":"Exomorfología y anatomía de órganos vegetativos aéreos en especies de Flourensia DC. (Asteraceae) con importancia fi toquímica","resumen":"(Exomorfología y Anatomía de órganos vegetativos en especies de Flourensia DC. (Asteraceae) con importanciafotoquímica). El género Flourensia DC. es americano y comprende 32 especies. Son arbustos resinosos utilizadosen medicina popular; poseen un potencial valor económico, por lo que, en algunas especies representantes, se hancaracterizado sus compuestos químicos y determinado algunos posibles usos. En el presente trabajo, se estudió laexomorfología y anatomía de órganos vegetativos de F. hirta S. F. Blake, F. leptopoda S. F. Blake, F. niederleinii S. F.Blake y F. tortuosa Griseb., especies endémicas del centro de Argentina. Se observó que todas son similares en cuantoa la anatomía de hoja y tallo. En cuanto al estudio de la epidermis foliar, se concluye que es posible diferenciar lasespecies teniendo en cuenta la frecuencia estomática y la presencia de tricomas. Finalmente, las diferencias másnotables se encontraron en la exomorfología foliar ya que se observó una gran variación en cuanto a la forma delas hojas y tamaño de las láminas y pecíolos. Con respecto a las estructuras secretoras, se encontraron tricomas yconductos secretores esquizógenos en las hojas y los tallos de todas las especies, las cuales serían responsables de laproducción y secreción de las resina","palabras_clave":"Asteraceae|Flourensia|Anatomía"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88978,"idioma_id":5,"titulo":"Mapeo de genes ribosómicos y heterocromatina en seis especies de Lycium de Sudamérica (Solanaceae)","resumen":"El clado Lycieae (Solanaceae) reune 92 especies, actualmente agrupadas en un único género, Lycium. Se realizó un estudio citogenético en seis especies sudamericanas de este género,usándose por primera vez en el grupo la técnica de FISH, además de la técnica de bandeo CMA\/DAPI. Se emplearon ápices radicales de las siguientes especies: L. boerhaviifolium (previamente Grabowskia), L. bridgesii (previamente Phrodus), el tetraploide L. chilense y los diploides L. cestroides, L. ciliatum y L. tenuispinosum. Se confirmó el número básico x=12. La técnica de bandeo reveló la presencia de una banda CMA+\/DAPI- asociada a NORs en el primer par metacéntrico en las especies diploides, y en los dos primeros pares m en la tetraploide. Además, L. tenuispinosum mostró una banda intercalar CMA+\/DAPI- en uno de sus cromosomas, en tanto que en L. bridgesii se encontraron bandas terminales e intercalares en todos los cromosomas. Con la técnica de FISH se observó que los loci 18-5,8-26S fueron consistentes con los bloques CMA+\/DAPI-\/NORs. Las especies diploides presentaron siempre un parcromosómico m portador de genes ADNr 5S, mientras que la especie tetraploide presentó dos pares, concordando con su nivel de ploidía. En las especies estudiadas, la diversificación no fue acompañada por rearreglos cromosómicos estructurales significativos, excepto L. bridgesii, que se destaca por poseer una fórmula cariotípica distinta y un mayor porcentaje de heterocromatina.","palabras_clave":"bandeo cromosomico|citogenetica|evolucion|sistematica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88979,"idioma_id":4,"titulo":"The scaler mode in the Pierre Auger Observatory to study heliospheric modulation of cosmic rays","resumen":"The impact of the solar activity on the heliosphere has a strong influence on the modulation of the flux of low energy galactic cosmic rays arriving at Earth. Different instruments, such as neutron monitors or muon detectors, have been recording the variability of the cosmic ray flux at ground level for several decades. Although the Pierre Auger Observatory was designed to observe cosmic rays at the highest energies, it also records the count rates of low energy secondary particles (the scaler mode) for the self-calibration of its surface detector array. From observations using the scaler mode at the Pierre Auger Observatory, modulation of galactic cosmic rays due to solar transient activity has been observed (e.g., Forbush decreases). Due to the high total count rate coming from the combined area of its detectors, the Pierre Auger Observatory (its detectors have a total area greater than 16,000 m2) detects a flux of secondary particles of the order of &#8764;108 counts per minute. Time variations of the cosmic ray flux related to the activity of the heliosphere can be determined with high accuracy. In this paper we briefly describe the scaler mode and analyze a Forbush decrease together with the interplanetary coronal mass ejection that originated it. The Auger scaler data are now publicly available.","palabras_clave":"COSMIC RAYS|CHERENKOV DETECTORS|INTERPLANETARY CORONAL MASS EJECTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88980,"idioma_id":4,"titulo":"Expansion of magnetic clouds in the outer heliosphere","resumen":"Context. A large amount of magnetized plasma is frequently ejected from the Sun as coronal mass ejections (CMEs). Some of theseejections are detected in the solar wind as magnetic clouds (MCs) that have flux rope signatures.Aims. Magnetic clouds are structures that typically expand in the inner heliosphere. We derive the expansion properties of MCs in theouter heliosphere from one to five astronomical units to compare them with those in the inner heliosphere.Methods. We analyzeMCs observed by the Ulysses spacecraft using in situ magnetic field and plasma measurements. The MC boundariesare defined in the MC frame after defining the MC axis with a minimum variance method applied only to the flux rope structure.As in the inner heliosphere, a large fraction of the velocity profile within MCs is close to a linear function of time. This is indicativeof a self-similar expansion and a MC size that locally follows a power-law of the solar distance with an exponent called &#950;. We derivethe value of &#950; from the in situ velocity data.Results. We analyze separately the non-perturbedMCs (cases showing a linear velocity profile almost for the full event), and perturbedMCs (cases showing a strongly distorted velocity profile). We find that non-perturbed MCs expand with a similar non-dimensionalexpansion rate (&#950; = 1.05 ± 0.34), i.e. slightly faster than at the solar distance and in the inner heliosphere (&#950; = 0.91 ± 0.23). The subsetof perturbed MCs expands, as in the inner heliosphere, at a significantly lower rate and with a larger dispersion (&#950; = 0.28 ± 0.52)as expected from the temporal evolution found in numerical simulations. This local measure of the expansion also agrees with thedistribution with distance of MC size, mean magnetic field, and plasma parameters. The MCs interacting with a strong field region,e.g. another MC, have the most variable expansion rate (ranging from compression to over-expansion).","palabras_clave":"magnetohydrodynamics (MHD)|Sun: coronal mass ejections (CMEs)|solar wind|interplanetary medium"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88981,"idioma_id":4,"titulo":"Nature and origin of very high-energy cosmic rays","resumen":"The Earth is exposed to a permanent rain of cosmic particles from  outer space [1]. Most of the particles are fully ionised atomic nuclei,  moving with relativistic energies. The bulk of them with energies up  to 1017 eV originate within our Milky Way. They are most likely accelerated  in supernova remnants. Some particles have a thousand times  higher energies, i.e., around 1020 eV. This corresponds to the kinetic  energy of a tennis ball with a mass of 50 g and a velocity of 90 km\/h.","palabras_clave":"PIERRE AUGER|ULTRA HIGH ENERGY COSMIC RAYS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88982,"idioma_id":4,"titulo":"Antennas for the detection of radio emission pulses from cosmic-ray induced air showers at the Pierre Auger Observatory","resumen":"The Pierre Auger Observatory is exploring the potential of the radio detection technique to study extensive air showers induced by ultra-high energy cosmic rays.  The Auger Engineering Radio Array (AERA) addresses both technological and scientific aspects of the radio    technique. A first phase of AERA has been operating since September 2010 with detector stations observing radio signals at frequencies between 30 and 80 MHz.  In this paper we present comparative studies to identify and optimize the antenna design for the final configuration of AERA    consisting of 160 individual radio detector stations. The transient nature of the air shower signal requires a detailed description of the antenna sensor. As the ultra-wideband reception of pulses is not    widely discussed in antenna literature, we review the relevant antenna characteristics and enhance theoretical considerations towards the impulse response of antennas including polarization effects and multiple signal reflections.  On the basis of the vector effective length we study the transient    response characteristics of three candidate antennas in the time domain. Observing the variation of the continuous galactic background intensity we rank the antennas with respect to the noise level added to the galactic signaL  ","palabras_clave":"Large detector systems for particle and astroparticle physics|Antennas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88983,"idioma_id":4,"titulo":"Can a halo CME from the limb be geoeffective?","resumen":"The probability for a halo coronal mass ejection (CME) to be geoeffective is assumedto be higher the closer the CME launch site is located to the solar central meridian.However, events far from the central meridian may produce severe geomagnetic storms,like the case in April 2000. In this work, we study the possible geoeffectiveness of full haloCMEs with the source region situated at solar limb. For this task, we select all limb fullhalo (LFH) CMEs that occurred during solar cycle 23, and we search for signatures ofgeoeffectiveness between 1 and 5 days after the first appearance of each CME in theLASCO C2 field of view. When signatures of geomagnetic activity are observed in theselected time window, interplanetary data are carefully analyzed in order to look for thecause of the geomagnetic disturbance. Finally, a possible association between geoeffectiveinterplanetary signatures and every LFH CME in solar cycle 23 is checked in order todecide on the CME\u2019s geoeffectiveness. After a detailed analysis of solar, interplanetary,and geomagnetic data, we conclude that of the 25 investigated events, there are only fourgeoeffective LFH CMEs, all coming from the west limb. The geoeffectiveness of theseevents seems to be moderate, turning to intense in two of them as a result of cumulativeeffects from previous mass ejections. We conclude that ejections from solar locations closeto the west limb should be considered in space weather, at least as sources of moderatedisturbances.","palabras_clave":"Space Weather|Coronal Mass Ejections"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88984,"idioma_id":5,"titulo":"Diseño de un programa de conservación de un hato de criollo Yacumeño asistido por marcadores genéticos en Santa Cruz - Bolivia","resumen":"La Facultad de Ciencias Veterinarias de la UAGRM consolido un programa de conservación del ganado Bovino Criollo Yacumeño a partir del año 2004. La conservación de recursos zoogenéticos generalmente se realiza en poblaciones pequeñas, las cuales tienen un tamaño poblacional efectivo muy reducido. En estos casos es importante realizar apareamientos que mantengan la variabilidad genética alta y los niveles de consanguinidad bajos. El objetivo del presente trabajo consistió en determinar las paternidades y los linajes paternos mediante el uso de marcadores moleculares. El ADN se extrajo partir de muestras de sangre de los 149 animales del hato y se procedió a genotipificar todos los individuos utilizando 18 microsatélites y 7 marcadores del cromosoma Y. Los resultados obtenidos permitieron identificar dos grandes grupos de vacas y 3 linajes paternos. Esta información servirá para diseñar un programa reproductivo que evite en lo posible la perdida de la variabilidad genética y mantenga niveles aceptables de consaguinidad en el hato a conservar.","palabras_clave":"Conservación|Linajes paternos|Marcadores moleculares|Paternidades"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88985,"idioma_id":4,"titulo":"Does acclimation at higher temperatures affect the locomotor performance of one of the southernmost reptiles in the world?","resumen":"When an animal in the laboratory experiences a change in temperature, physiological processes are affected but they stabilize under the new temperature condition over a few weeks by a process of phenotypic plasticity called acclimation, but whether an organism can acclimate or not depends on the trait and the taxon. Liolaemus sarmientoi is one of the southernmost reptiles in the world, inhabiting the extreme and arid environment of Patagonia, Argentina, characterised by great seasonal climatic variation and cold air temperatures throughout the year (mean air temperature of 8 ºC; ranging from 1.2 to 14.1 ºC). However, these lizards prefer body temperatures in the laboratory ranging from 26.3 to 37.8 ºC (mean Tpref = 34.4 ºC ± 0.28), temperatures that they rarely achieve in nature. Herein, we explore the effects of thermal acclimation on performance of L. sarmientoi at a temperature higher than their mean natural environmental temperature during their activity period (austral spring-summer). We analysed the speed in sprint and long runs at medium and high temperatures in the field and again after a period of acclimation of 20 days at 21 ºC. Acclimation to higher and constant temperature resulted in a decrease in running speed in both long and sprint runs, suggesting potentially negative effects for natural populations if environmental temperature increases.","palabras_clave":"LIZARD|LIOLAEMUS SARMIENTOI|ACCLIMATION|LOCOMOTOR PERFORMANCE|HIGH LATITUDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88986,"idioma_id":4,"titulo":"Emerging engineering principles for yield improvement in microbial cell design","resumen":"Metabolic Engineering has undertaken a rapid transformation in the last ten years making real progress towards the production of a wide range of molecules and fine chemicals using a designed cellular host. However, the maximization of product yields through pathway optimization is a constant and central challenge of this field. Traditional methods used to improve the production of target compounds from engineered biosynthetic pathways in non-native hosts include: codon usage optimization, elimination of the accumulation of toxic intermediates or byproducts, enhanced production of rate-limiting enzymes, selection of appropriate promoter and ribosome binding sites, application of directed evolution of enzymes, and chassis re-circuit. Overall, these approaches tend to be specific for each engineering project rather than a systematic practice based on a more generalizable strategy. In this mini-review, we highlight some novel and extensive approaches and tools intended to address the improvement of a target product formation, founded in sophisticated principles such as dynamic control, pathway genes modularization, and flux modeling.","palabras_clave":"METABOLIC ENGINEERING|CELL DESIGN|MODULARIZATION|METABOLIC FLUX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88987,"idioma_id":4,"titulo":"Induction of somatic growth in juvenile crayfish Cherax quadricarinatus (Decapoda, Parastacidae) by ecdysone and insulin growth factor","resumen":"The effect of ecdysone and IGF-1 on the somatic growth of juvenile crayfish Cherax quadricarinatus, was examined both in vitro and in vivo. After 24 h of incubating explants of abdominal muscle, protein synthesis was augmented by exposure to 0.15 &#956;M of ecdysone, 0.02 &#956;M of IGF-1 or the combination of both hormones. The in vivo experiments were done by feeding the juveniles a pellet food supplemented with ecdysone, IGF-1 or a combination of both hormones, at doses equivalents to those that had an effect in the in vitro experiment. Animals fed IGF-1 or IGF-1 and ecdysone enriched pellets showed a higher weight gain than controls, while no differences were detected in the case of juveniles fed pellets enriched with ecdysone alone. In close correspondence with these results, and also with the in vitro results, a significant increment in protein content was found in muscle of crayfish treated with IGF-1, alone or in combination with ecdysone. On the other hand, significant lower lipid content was found in the hepatopancreas of both groups treated with IGF-1. Our results confirm the in vivo anabolic effects of IGF-1 on crustaceans, in terms of enhancing growth and protein synthesis, therefore identifying this hormone as a potential tool for crayfish culture.","palabras_clave":"CRAYFISH|SOMATIC GROWTH|ECDYSONE|IGF-1|PROTEIN SYNTHESIS|ENERGETIC RESERVES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88988,"idioma_id":4,"titulo":"Human occupations during the Middle Holocene and beginning of the Late Holocene in the Pocitos basin, Puna of Salta, Argentina: New research and regional comparison","resumen":"This article analyzes the human occupations of the Middle Holocene and beginnings of the Late Holocene at Pocitos as compared with other areas of the Salta Puna (Highlands region) such as Pastos Grandes and  more generally in a macroregional framework (south-central Andes). Pocitos is a basin presenting an arid environment of salt flat, and with very scant primary productivity. Its location in the Salta Puna, midway  between the Puna of Jujuy and that of Catamarca, is suitable for social interaction and cultural communication. From information on surface and stratified contexts from the Middle Holocene and beginnings of the Late Holocene the technological and faunal variability in the area is analyzed. The site serving as a chronological referential base is Abrigo Pozo Cavado.","palabras_clave":"Pocitos|Middle Holocene|Archaeology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88989,"idioma_id":4,"titulo":"Proceeding Título: The importance of natural framework in cytotoxicity of diamide derivatives","resumen":"Several diamides have shown a large number of bioactivities, includingcytotoxic, antibacterial, antifungal, and anti-inflammatoryeffects. In this order we work in synthetize a group of cytotoxiccompounds derivatives from natural products which ensure goodlevels of bioactivity keeping the specificity provided by naturalframework. Diamides were synthetized by Ugi reaction using acetone,aniline or benzylamine and terbutilisocianide. As source ofcarboxyl group was used a natural labdane.","palabras_clave":"diamide|cytotoxicity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88990,"idioma_id":4,"titulo":"Andean oblique folds in the Cordillera Oriental - Northwestern Argentina: Insights from analogue models","resumen":"The dominant Cenozoic structural grain in northwestern Argentina trends northesouth. However,several oblique folds have been mapped, mainly in the Cordillera Oriental and the Sistema de Santa Bárbara. Two oblique NEeSW-trending anticlines are well exposed in the Luracatao Valley-Salta, along the western border of the Cordillera Oriental. These oblique anticlines are defined by the Palaeogene Santa Bárbara Subgroup and are cut by the reverse faults bounding the Luracatao Valley. We constructed  analogue models to simulate the generation of oblique NEeSW anticlines inside the narrow, trough-like Luracatao Valley. Orthogonal compression and basement oblique heterogeneities, oblique compression and basement oblique heterogeneities, and oblique compression configurations were tested in the models. The first two configurations simulate the anticline formation well. In addition, we analyse dextral rotation and the influence of Neoproterozoic basement\/Cretaceous rift structures as the cause of the oblique orientation. The analogue models suggest pre-Andean oblique structures controlling the oblique orientation of these Andean folds despite being a second-order planes of weakness.","palabras_clave":"Andean oblique folds|Luracatao valley|Cordillera Oriental|Analogue models"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88991,"idioma_id":4,"titulo":"Morphology, morphometry, histochemistry and lectin histochemistry of the vagina of the plains viscacha (Lagostomus maximus)","resumen":"The aim of the present work was to describe the morphology of the vagina in Lagostomus maximus as well as to characterize its epithelial cells using morphometrical and histochemical techniques (variations of PAS, Alcian Blue and lectinhistochemistry). Thirty five adult sexually mature females were captured in their natural environment during four periods of the year and their genital organs were dissected. The vagina of the viscacha is a tubular organ, 7.16±0.35 cm long and 1.75±0.05 cm in diameter. The organ is divided longitudinally by a medial septum in the cranial region having a unique cavity in the caudal region. The vagina wall has three tunics: mucosa, muscularis and adventitia or serosa according to the region. In both cranial and caudal regions the epithelium is stratified but their characteristics vary depending on the physiological state. Thus, in anoestrous, non-pregnant females show a stratified epithelium of two to three cellular layers with cylindrical PAS+ superficial mucous cells; during follicular phase the epithelium of the vagina is squamous stratified and cornified; females at early pregnancy, middle pregnancy and pregnancy at term present a cylindrical stratified epithelium with mucous cells. Glycoproteins in mucous cells were detected using several histochemical techniques (PAS, PA*S, KOH\/PA*\/BH\/PAS, Alcian Blue pH 0.5, pH 1, pH 2,5 and 0.006M). Lectinhistochemical analysis showed that UEA-I and RCA-1 lectins strongly or moderately reacted with epithelial cells in all the analysed stages. These results indicate the presence of L-fucose and â-galactose. The binding with other lectins was variable. ","palabras_clave":"histricomorph|rodent|mucous cells|morphometry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88992,"idioma_id":4,"titulo":"Characterization of glycoconjugates in the pharyngeal cavity and the oesophagus of Odontesthes bonariensis by lectins","resumen":"  Seven types of biotinylated lectins were used to examine glycoconjugates (GCs) expression patterns in  the mucosa of the pharyngeal cavity and the oesophagus of Odontesthes bonariensis. Con-A, RCA-I, and WGA   binding sites were positive for glycocalyx, epithelial cells, and mucous cells in both organs with similar reaction  patterns. PNA just stained glycocalyx and epithelial cells in the mucosa in both organs. DBA, SBA, and UEA-I  binding sites were positive for glycocalyx, epithelial cells, and mucous cells in both organs with similar reaction  patterns. PNA just stained glycocalyx and epithelial cells in the mucosa in both organs. DBA, SBA, and UEA-I  Odontesthes bonariensis. Con-A, RCA-I, and WGA   binding sites were positive for glycocalyx, epithelial cells, and mucous cells in both organs with similar reaction  patterns. PNA just stained glycocalyx and epithelial cells in the mucosa in both organs. DBA, SBA, and UEA-I  stained only the oesophagus, and a greater affinity to glycocalyx and the epithelial cells was observed. The  results of this study were discussed and their possible functional implications were compared.","palabras_clave":"GLYCOCONJUGATES|LECTIN HISTOCHEMISTRY|OESOPHAGUS|PHARYNGEAL CAVITY|SILVERSIDE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88993,"idioma_id":4,"titulo":"Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines","resumen":"Purpose: The objective of the present study was to examine the consequences of a mild hyperthermia in human tumor cell lines deficient and proficient in the DNA Mismatch repair system (MMR) to advance our understanding on the relationship between MMR and Heat Shock Proteins (HSPs).   Materials and methods: The human colon carcinoma cell lines HCT116 (parent cells), HCT116+ch2 (MMR-deficient), and HCT116+ch3 (MMR-proficient) were used. Cells were incubated at 41°C and or 42°C for 1 hour and then at 37°C for 4 and or 24 hours. The expression of HSP27 and HSP72 was evaluated by immunocytochemistry. HSP27, HSP72, hMLH1 and hMSH2 levels were assessed by Western blotting in nuclear and cytoplasmic fractions. The alkaline comet assay was used to evaluate the DNA damage.   Results: The mild hyperthermia significantly increased the protein expression levels of HSP27 and HSP72 in all cell lines, which was higher in the cytoplasm and nucleus of HCT116+ch3 cells. We also observed that heat induced translocation of hMLH1 and hMSH2 proteins from the nucleus to the cytoplasm in HCT116+ch3 cells. The comet assay revealed that HCT116 parent cells were more resistant to heat-induced DNA damage. However, the MMR-proficient and deficient cell lines repaired the DNA damage at the same rate.   Conclusions: The present study demonstrates that hyperthermia induced the nuclear accumulation of HSP27 and HSP72 and affected the subcellular localization of hMLH1 and hMSH2 in HCT116+ch3 cells. Our findings suggest that the MMR system is not a direct determining factor for the different heat shock response in HCT116 cells.","palabras_clave":"MILD HYPERTHERMIA|HETA SHOCK PROTEINS|MISMATCH REPAIR|COMET ASSAY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88994,"idioma_id":4,"titulo":"Molecular typing of Adenoviruses in pediatric respiratory infections in Buenos Aires, Argentina (1999- 2010)","resumen":"Background: The human adenovirus (HAdV) types most commonly found in respiratory samples belong to HAdV species C (HAdV-C1, -C2, -C5, and -C6) and to HAdV species B (HAdV-B3 and -B7). Several studies in South America have shown the association between severe respiratory infections and subspecies B1.Objectives: The aim of this study was to identify the adenovirus types associated with acute lower respiratory tract infections in children, found as single or coinfections, throughout a 12-year period.Study design: All samples that tested positive for adenovirus by immunofluorescence assay from January 1999 to December 2010 were typed by evaluating a set of four viral genes (E1A, VA, hexon and fiber). Quantitative PCRs for HAdV-B and HAdV-C species were performed to compare the viral load found in single infections and coinfections.Results: From a total of 743 HAdV, 654 (88%) were single infections and 89 (12%) coinfections. From the 654 single HAdV infections, members of four species were present: species B (n = 492, 75.23%), species C (n = 138, 21.1%), species E (n = 19, 2.91%), and species D (n = 5, 0.76%). Only members of species B (n = 109, 57.67%) and species C (n = 80, 42.33%) were detected in coinfections. HAdV-B7 and HAdV-B3 were the most prevalent types (n = 308, 36.54%; n = 230, 27.28% respectively) and HAdV-C1, -C2, -E4, -C5, -C6, -D8, -B11, -B14 and -B21 were also detected. Viral loads for species C viruses were higher in single infections than in coinfections (p &lt; 0.01), whereas the opposite was observed for species B viruses (p &lt; 0.0001).Conclusions: This study provides a thorough description of adenovirus circulation and diversity in Buenos Aires in a 12-year period. The high proportion of coinfections found in this work shows that this phenomenom might be more common than expected.","palabras_clave":"ADENOVIRUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88995,"idioma_id":4,"titulo":"Molecular Evidence of St. Louis Encephalitis Virus Infections in Patients in Buenos Aires, Argentina","resumen":"We report two cases of St. Louis encephalitis where the virus was detected in patients\u2019  sera directly by molecular techniques allowing subsequent typing.. Phylogenetic analysis of both  samples showed that NS5 sequences clustered with viruses previously classified as genotype III.","palabras_clave":"ST. LOUIS ENCEPHALITIS VIRUS|MOLECULAR TYPING|NEXT GENERATION SEQUENCING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88996,"idioma_id":4,"titulo":"New Insights Into Sexually Dimorphic Skin Glands of Anurans: The Structure and Ultrastructure of the Mental and Lateral Glands in Hypsiboas punctatus (Amphibia: Anura: Hylidae)","resumen":"Many anuran species are characterized by sexually dimorphic skin glands. These glands often are concentrated on speci&#64257;c areas, such as the mental region, &#64258;anks, or the nuptial pads. We studied the histology and histochemistry of mental and lateral glandsin Hypsiboas punctatus, and compared them to skin  from other body regions. We describe four types of dermal glands, two types of mucous and two types of serous glands. The mucous glands are formed by a single layered epithelium. The mucocytes surrounding a central lumen are &#64257;lled with polyhedral granules. Ordinary mucoid content, and small granules. Specialized mucous glands are characterized by a larger size, a columnar epithelium, a proteinaceous content and  larger granules. Both types of serous glands are syncytial and share some structural features including size,  shape, and morphology of secretory granules. However, ordinary and specialized serous glands differ in their  histochemical properties, size and appearance of secretory granules, and glandular outlets. The specialized  type of mucous glands in H. punctatus resembles most SDSGs described in anurans, whereas the presence of  specialized serous glands that are sexually dimorphic is less common. Both specialized glands occur only in  mental and lateral regions of males, whereas ordinary mucous and ordinary serous glands occur in males and  females.","palabras_clave":"anfibios|dimorfismo sexual|distribución glandular|comunicación química"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88997,"idioma_id":5,"titulo":"MONITOREO Y CARACTERIZACIÓN DE SISTEMAS FOTOVOLTAICOS                   CONECTADOS A RED","resumen":"&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Para determinar la condición de funcionamiento de sistemas fotovoltaicos conectados a red (SFCR) deforma continua es necesario contar con una metodología capaz de determinar la potencia que entrega el sistema, sininterferir en su operación, y compararla con el valor real que debe aportar. En el presente trabajo se evalúa unalgoritmo para determinar anomalías en la generación en estos sistemas a través del monitoreo de la potenciagenerada. Resultados del seguimiento continuo del sistema son contrastados con valores obtenidos en lacaracterización, realizada a través del empleo de una trazador de curvas I-V basado en una carga capacitiva. Losresultados obtenidos permiten concluir que es posible caracterizar adecuadamente el punto de máxima potencia desistemas fotovoltaicos conectados a red con desvíos menores al 2 % utilizando datos parciales de la curva I-V. De estaforma, se cuenta con una herramienta que permite evaluar las condiciones de generación de SFCR en funcionamientosin interferir con la operación del mismo.","palabras_clave":"SOLAR|FOTOVOLTAICO|RED|CURVA I-V"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88998,"idioma_id":5,"titulo":"EVALUACIÓN DEL DESEMPEÑO DE SISTEMAS FOTOVOLTAICOS AUTÓNOMOS EN ZONAS RURALES DE LA PROVINCIA DE CORRIENTES, ARGENTINA","resumen":"&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; El uso de sistemas fotovoltaicos autónomos (SFA) durante los últimos años, demostró que es una soluciónpresente y del futuro para la electrificación rural descentralizada (ERD). Sin embargo, se observa que la falta de unadecuado dimensionamiento, equipamiento y mantenimiento, afecta al funcionamiento de sistemas instalados y podríancomprometer el éxito de los próximos proyectos. El nivel de confiabilidad de cada SFA instalado depende directamentede factores típicos de su región, como lo son las condiciones climáticas. En la provincia de Corrientes, en Argentina, elGrupo Energías Renovables (GER) está llevando a cabo un estudio completo de caracterización de 85 SFA instaladosen escuelas rurales, con el objetivo de ofrecer soluciones para optimizar el comportamiento de tales sistemas en lazona. Se realizaron ensayos en laboratorio de módulos fotovoltaicos (FV) y baterías a fin de controlar suscaracterísticas nominales. Además, un monitoreo in situ de un SFA en condiciones reales de operación y datosgenerales de mantenimiento, permitieron analizar problemas específicos que afectan directamente al funcionamientode los SFA. Se observaron casos concretos de mala calidad de módulos FV, de inversores afectados por la presenciade ranas, y de configuraciones de SFA inadecuadas en el control de carga y descarga de las baterías, provocandopérdidas prematuras de capacidad de las mismas. Finalmente, se concluye que un proyecto de electrificación con SFAno puede limitarse en las tareas de instalación. Se debe prever, financiar y organizar también un mantenimientoadecuado, sin el cual no se podrá lograr un éxito a largo plazo.","palabras_clave":"RADIACION SOLAR|FOTOVOLTAICO|DESCENTRALIZADO|RURAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":88999,"idioma_id":5,"titulo":"MEDIDA EN LABORATORIO DE LA EMISIÓN UV EMITIDA   POR LÁMPARAS FLUORESCENTES COMPACTAS.","resumen":"&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; En el presente trabajo se muestran los primeros resultados de los ensayos realizados a un reducido conjunto delámparas fluorescentes compactas (FLC), con el fin de determinar su respuesta espectral en la zona visible y también en elultravioleta cercano. Los mismos se realizaron con las lámparas nuevas y se repitió después de un determinado período deutilización. Las mediciones se realizan en una cámara diseñada para tal fin, midiéndose también la intensidad luminosa en diferentesángulos. Del trabajo se desprende que si bien la respuesta espectral no se modificó demasiado, algunas lámparas. presentaron unaimportante disminución de la intensidad. Por otra parte, puede considerarse que el objetivo de los ensayos es por una parte, laobtención de resultados preliminares, y por otro, la puesta a punto de la técnica empleada.","palabras_clave":"FLUORESCENTE|ULTRAVIOLETA|CAMARA|FLUJO LUMINOSOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89000,"idioma_id":5,"titulo":"ANÁLISIS DE PÉRDIDAS POR DESADAPTACIÓN EN CELDAS Y MÓDULOS FOTOVOLTAICOS","resumen":"&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; El presente trabajo analiza el efecto que se produce en un módulo fotovoltaico o arreglo (FV) debido a unacelda o módulo FV en condiciones de pérdidas por desadaptación eléctrica. Se utilizan modelos matemáticos de celdas FV através de una herramienta de simulación de circuitos electrónicos de código abierto capaz de simular el comportamientoeléctrico de módulos o arreglos fotovoltaicos tanto en condiciones normales de generación como en condiciones dedesadaptación eléctrica. La precisión obtenida en los resultados en base del contraste de curvas I-V experimentales concurvas I-V simuladas logra vincular el efecto producido por una celda defectuosa dentro de un módulo FV con los parámetroscorrespondientes al modelo equivalente eléctrico, y vincular el efecto que se produce en el sombreado parcial de una celda deun módulo FV. Como conclusión se destaca el hecho de que esta metodología ayuda a establecer que sucede en un arreglofotovoltaico que presenta condiciones de pérdidas por desadaptación.","palabras_clave":"SIMULACION|FOTOVOLTAICO|CURVAS i-v|MISMATCH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89001,"idioma_id":4,"titulo":"Influence of the shape of the particles in the solidification of  composite materials","resumen":"The shape of a solidifying interface is generally affected  when it encounters foreign inert particles. The degree of   deformation depends on the morphology and physical properties of the particles, the melt, the solid and the external fields,   affecting the pushing and capture process of the particles.  The particle can be trapped by the interface at slower   solidification velocity than that predicted by simple models which do not include any deformation of the interface. In all   cases this interaction strongly determines the segregation of particles in the microstructure  and therefore affecting the   physical and physicochemical properties of the final material. In the present report the interaction between particle and   interface is analyzed by means of a mathematical model employing the finite element method. The effect on interface   shape of different particle shapes and relative thermal conductivities between particle and melt was studied. Thermal field   results show that when the particle is more conductive than the melt, the interface is concave. Comparing the concave   interfaces for different particle shapes it is observed that, when the particle is not spherical the separation particle-interface   at the edge of the particle is the smallest. As a consequence of this phenomenon, which occurs in non-spherical particles,   there is a remaining amount of melt between particle and solid which is the last in solidify.","palabras_clave":"numerical modeling|pushing|solidification|composites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89002,"idioma_id":4,"titulo":"The influence of gravity on the CET in diluted Zn-Al alloys","resumen":"In a solidification process, the microstructure depends on the alloy characteristics and is a function mainly of the temperature evolution ahead the solid\/liquid interphase. Among the several phenomena occurring during solidification, like solute segregation and morphology  stability, one of the most important is dendritic growth. The most important dendrite parameters are the primary, secondary and tertiary arm spacings due to their influence on mechanical properties. An efficient method of examining the evolution of dendrite arms is to apply steady-state directional solidification with an imposed growth rate, V, and a thermal gradient, G, at the solid\/liquid interphase. In this work, experiments were performed under unidirectional solidification in a device cooled with water, and Zn-1%Al and Zn-2%Al (wt%) alloys were solidified in a vertical upward (0º), inclined at 30° and 45° to the vertical and horizontally upward (90º to the vertical).The position of the transition from columnar-to-equiaxed structure (CET) through macro- and micro-analysis was determined, and significant thermal parameters by recording temperature-time data. The results show that the direction of growth of dendrites is about the direction of heat extraction and that the angle of inclination of the columnar grains with the longitudinal axis of the alloy sample coincides approximately with the angle of inclination of the furnace.","palabras_clave":"solidification|interphases|alloys|columnar to equiaxed transition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89003,"idioma_id":4,"titulo":"Structural Characterization and Dimensional Analysis During  Directional Solidification of Al-Cu Alloys","resumen":"The columnar - to - equiaxed transition (CET) was investigated in Al-Cu alloys (Al-1wt.%Cu, Al-4.5wt.%Cu, Al-15wt.%Cu and Al-33.2wt.%Cu) solidified directionally upward from a chill face. The CET occurs when the temperature gradient in the melt ahead of the columnar front reaches minimum and critical values. Two dimensionless numbers ( and  numbers) that can relate the system parameters (cooling rate, local solidification time and liquidus temperature of the alloy) were defined. T which shows a linear relationship with the local solidification time and t , that for the Al-rich region in the Al-Cu system, strongly depend on the macrostructure. These results are important to correlate the experimental values of physical quantities, which are relevant to describe the solidification process","palabras_clave":"solidification|columnar to equiaxed transition|aluminum - copper alloys|microstrucure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89004,"idioma_id":5,"titulo":"Espectro trófico de la Gaviota de Olrog (Larus atlanticus) en dos sitios de invernada de Argentina y Uruguay","resumen":"La composición de la dieta de la Gaviota de Olrog (Larus atlanticus) fue monitoreada durante el período no reproductivo 2008 en dos lagunas costeras: Mar Chiquita (Argentina) y José Ignacio (Uruguay). La abundancia de la Gaviota de Olrog fue similar en los dos sitios, registrándose en ambos sitios una menor cantidad de juveniles que sub-adultos y adultos. La dieta fue determinada por medio del análisis de egagrópilas. Los cangrejos Neohelice granulata y Cyrtograpsus angulatus fueron las presas más importantes en ambos sitios. Las tallas de N. granulata consumidos en Mar Chiquita fueron mayores a las tallas de los consumidos en José Ignacio, mientras que las tallas de C. angulatus consumidos en José Ignacio fueron mayores que en Mar Chiquita. Las tallas de ambas especies de cangrejos variaron entre estaciones. En los dos sitios el consumo de N. granulata estuvo desviado hacia los machos, pero de C. angulatus hubo un mayor consumo de hembras en José Ignacio. La consistencia observada en el consumo de cangrejos varúnidos en estos humedales costeros durante la invernada, junto con el estado de conservación vulnerable de la Gaviota de Olrog muestra la importancia de conservar ambientes de invernada con cangrejales, no obstante que la especie utilice recursos tróficos alternativos no reflejados en el análisis de egagrópilas.","palabras_clave":"Gaviota de Olrog|Larus atlanticus|Laguna Mar Chiquita|Laguna Jose Ignacio"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89005,"idioma_id":4,"titulo":"Seabird and marine mammal attendance in the Chub mackerel Scomber japonicus semi-industrial Argentinian purse seine fishery","resumen":"We assessed for the first time marine bird and mammal attendance in the Chub mackerel Scomber japonicus semi-industrial coastal purse seine fishery in northern Argentina. Information was gathered during a fishery run from late spring 2007 to early summer 2008. Sixteen marine top predator species attended vessels, and the most abundant seabirds (percent of overall individuals and percent of occurrence)were the Kelp Gull Larus dominicanus (25% and 40% respectively), and White-chinned Petrel Procellaria aequinoctialis (24% and 47% respectively). Other attending bird species were the Black-browed Albatross Thalassarche melanophrys (18.5% and 12% respectively) and South American Tern Sterna hirundinacea(30% and 22% respectively). The most abundant marine mammal\u2019s species was the South American Sea Lion Otaria flavescens (2% and 8% respectively). Analysis of environmental and operational variability affecting the abundance of the four main seabird species indicated a clear spatial variability in the numbers of seabirds attending coastal purse seiners. Other factors included fishing operation, time of day, seasonality, and wind intensity and wind direction. Neither seabird nor marine mammal species were observed to be incidentally taken during 82 fishing operations. The results of this study showed that the semi-industrial purse seine fishery operating in coastal waters in northern Argentina may have a relatively minor impact on some marine top predator populations mainly because (1) the fishing grounds are close to shore, and at relatively shallow depths, and (2) for economic reasons, the fishingfleet operates at considerable distance from dense schooling areas. Still, it has to be stressed that data were obtained during operations in which the levels of discards (<2%) were by far lower than the averageof 30% reported in the literature. Given this background, further studies including long-term monitoring are needed for an adequate modeling of the interactions and the identification of core areas for seabirdsinteracting with purse seiners in the waters of northern Argentina.","palabras_clave":"Chub mackerel fishery|seabird attendance|Marine mammal attendance|risk of interaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89006,"idioma_id":4,"titulo":"The diet of the South American sea lion (Otaria flavescens) at Río Negro, Patagonia, Argentina, during the winter-spring period","resumen":"The South American sea lion, Otaria flavescens (Shaw, 1800) population is steadily expanding along the Patagonian coast of Argentina in the last decades. However, little is known about the feeding ecology of the species in the area. The aim of this study was to analyze the food habits of O. flavescens from 91 scats collected at Río Negro province, during the winter and spring of 2005. Fish occurred in 96% of scats containing prey remains, followed by cephalopods (26%). Raneya brasiliensis (Kaup, 1856) was the most frequent and abundant species occurring in 58.6% of samples and constituting almost 50% of fish predated. Second in importance were Porichthys porosissimus (Cuvier, 1829) and Cynoscion guatucupa (Cuvier, 1830) in terms of occurrence (%FO 20.7) and numbers (29.6%) respectively. The squid Loligo gahi (d´Orbigny, 1835) was the most frequent cephalopod prey (42.1%), whereas Octopus tehuelchus (d´Orbigny, 1834) was the most abundant (77%). The higher amount and diversity of prey found in the spring in comparison with the winter season might be related to a higher feeding activity of seals or to a seasonal increase in food availability in the area.","palabras_clave":"Trophic ecology|Pinnipedia|fishes|cephalopods"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89007,"idioma_id":5,"titulo":"La fluidez lectora en los primeros grados : relación entre habilidades de decodificación, características textuales y comprensión. Un estudio piloto con niños hablantes de español.","resumen":"The purpose of this study was to examine the relationship between letter naming, isolated word recognition, word reading in text, and reading comprehension, which are all considered critical variables for reading fluency. The analysis of the variation of this relationship in the earliest years of primary school was undertaken.It may be assumed that, if comprehension is evaluated with a complex text, the accurate and rapid word reading might not be enough for comprehension because this process requires another kind of operations and knowledge that children could not possess.In order to explore the relationships between text features and decoding abilities, Spanish speaking children were tested in second, third, and fourth grades. They were assessed in letter naming, isolated word reading, word reading in texts and comprehension of narrative and expository texts.The results of this study show a difference among groups in all the variables: children´s performance increased throughout the school years. In fourth grade, children reached the highest scores in word reading in texts. The performance of 2nd and 3rd grade groups in decoding task was lower, between 40% and 60% of the total score. Although there were no differences in the amount of words read in one minute between narrative and expository texts, there were differences in comprehension: even though the performance is generally low, it was higher in narrative texts than in expository texts. These findings could indicate that both accurate and rapid word recognition skills could only explain part of the variation in reading comprehension which might be affected by text variables.","palabras_clave":"Fluidez Lectora|Comprensión|Reconocimiento de palabras|Características textuales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89008,"idioma_id":4,"titulo":"SIZE DEPENDENT CU DIELECTRIC FUNCTION FOR PLASMON SPECTROSCOPY. CHARACTERIZATION OF COLLOIDAL SUSPENSION GENERATED BY FS LASER ABLATION","resumen":"Copper metal nanoparticles (Nps) have received increasing interest during the last years due to their potential applications in several fields of science and technology. Their optical properties depend on the characteristics of the dielectric function of the metal, their size, and the type of environment. The contribution of free and bound electrons on the dielectric function of copper Nps is analyzed as well as their influence on its plasmonic properties. The contribution of free electrons is corrected for particle size under 10 nm, introducing a term inversely proportional to the particles radius in the damping constant. For bound electron contribution, interband transitions from the d-band to the conduction band are considered. For particles with sizes below 2 nm, the larger spacing between electronic energy levels must be taken into account by making the electronic density of states in the conduction band size-dependent. Considering these specific modifications, optical parameters and band energy values could be determined by fitting the bulk complex dielectric function. The obtained values were coefficient for bound electron contribution K bulk=2 &times; 10 24, gap energy E g=1.95 eV, Fermi energy E F=2.15 eV, and bound electrons damping constant &gamma; b=1.15 &times; 10 14 Hz. Based on the dielectric function determined in this way, experimental extinction spectra of colloid suspensions generated by ultrafast laser ablation of a solid copper target in liquids was fitted using the Drude-interband model and Mies theory. Depending on the experimental conditions and liquid medium, the particles in the suspension may have nanometric or subnanometric core size and may be capped with a shell of oxide. From the fitting, it was possible to determine the structure and size distribution of spherical bare core and core-shell copper Nps in the nanometer-subnanometer size range. These results were compared with those obtained by standard microscopy techniques such as AFM and HRTEM. There is a very good agreement between the three techniques, showing that optical extinction spectroscopy (OES) is a good complementary technique to standard high resolution electron microscopy and AFM for sizing spherical nanometric-subnanometric Nps. OES has also the advantage of a very good measurement statistics, due to the large number of probed particles across the sample cell. Besides, it avoids coalescence effects since the measurement is made directly on the colloidal suspension. &copy; 2012 American Institute of Physics.","palabras_clave":"DIELECTRIC FUNCTION|PLASMON SPECTROSCOPY|LASER ABLATION |COPPER NANOPARTICLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89009,"idioma_id":4,"titulo":"PLASMONIC PROPERTIES AND SIZING OF CORE-SHELL CU-CU2O NANOPARTICLES FABRICATED BY FEMTOSECOND LASER ABLATION IN LIQUIDS","resumen":"We report on the analysis of structure, configuration, and sizing of Cu and Cu oxide nanoparticles  (Nps) produced by femtosecond (fs) laser ablation of solid copper target in liquids. Laser pulse  energy ranged between 500 lJ and 50 lJ. Water and acetone were used to produce the colloidal  suspensions. The study was performed through optical extinction spectroscopy using Mie theory to  fit the full experimental spectra, considering free and bound electrons size dependent contributions  to the metal dielectric function. Raman spectroscopy and AFM technique were also used to  characterize the sample. Considering the possible oxidation of copper during the fabrication  process, two species (Cu and Cu2O) arranged in two structures (bare core or core-shell) and in two  configuration types (Cu-Cu2O or Cu2O-Cu) were considered for the fitting depending on the laser  pulse energy and the surrounding media. For water at high energy, it can be observed that a Cu-  Cu2O configuration fits the experimental spectra of the colloidal suspension, while for decreasing  energy and below a certain threshold, a Cu2O-Cu configuration needs to be included for the  optimum fit. Both species coexist for energies below 170 lJ for water. On the other hand, for  acetone at high energy, optimum fit of the full spectrum suggests the presence a bimodal Cu-Cu2O  core-shell Nps distribution while for decreasing energy and below a 70 lJ threshold energy value,  Cu2O-Cu core-shell Nps must be included, together with the former configuration, for the fit of the  full spectrum. We discuss possible reasons for the changes in the structural configuration of the core-shell Nps","palabras_clave":"nanoparticles|core-shell|fs laser| Copper"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89010,"idioma_id":5,"titulo":"Los hidrocarburos no convencionales en el escenario energético argentino","resumen":"Desde diciembre de 2010, y sobre todo a partir del conflicto que Repsol mantuvo con el Estado nacional y los provinciales entre enero y mayo de 2012, se ha instalado en la agenda pública la necesidad de avanzar en la extracción de hidrocarburos no convencionales: depósitos de petróleo y gas alojados a gran profundidad en formaciones geológicas de baja porosidad y permeabilidad, cuyas reservas ubicarían a la Argentina en tercer lugar, detrás de China y Estados Unidos. En el siguiente trabajo analizaré los factores estructurales internos y externos que alientan esta potencial ?revolución? del sector en el país, y sus posibles consecuencias sociales y ecológicas.","palabras_clave":"Hidrocarburos no convencionales|Política energética|YPF"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89011,"idioma_id":5,"titulo":"Trazos de sangre y fuego: ¿continuidad de la acumulación originaria en nuestra época?","resumen":"El despojo de la naturaleza vis á vis el cercamiento de los territorios de América Latina constituye un proceso central de la acumulación capitalista a escala planetaria. No obstante, ¿se trata de un fenómeno inédito, o de un mecanismo permanente en la geografía histórica del capitalismo desde su génesis? En este último caso, ¿qué particularidades y consecuencias tiene la depredación de los bienes naturales en la actual coyuntura regional? ¿Nos enfrentamos a un problema estrictamente ligado a los procesos vivos de orden biológico, o a una dimensión, entre otras, en el marco de un proceso que involucra tanto la mercantilización general de todo lo común (derechos sociales, servicios públicos, saberes ancestrales y populares), como una agudización de la contradicción capital trabajo?","palabras_clave":"Acumulación originaria|Acumulación por desposesión|Nuevos cercamientos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89012,"idioma_id":4,"titulo":"Microsatellite markers in candidate genes for wood properties and its application in functional diversity assessment in Eucalyptus globulus","resumen":"Background: Functional genetic markers have important implications for genetic analysis by providing direct estimation of functional diversity. Although high throughput sequencing techniques for functional diversity analysis are being developed nowadays, the use of already well established variable markers present in candidate genes is still an interesting alternative for mapping purposes and functional diversity studies. SSR markers are routinely used in most plant and animal breeding programs for many species including Eucalyptus. SSR markers derived from candidate genes (SSR-CG) can be used effectively in co-segregation studies and marker-assisted diversity management. Results: In the present study, eight new non reported SSRs were identified in seven candidate genes for wood properties in Eucalyptus globulus: cinnamoyl CoA reductase (CCR), homocysteine S-methyltransferase (HMT), shikimate kinase (SK), xyloglucan endotransglycosylase 2 (XTH2), cellulose synthase 3 (CesA3), glutathione S-transferase (GST) and the transcription factor LIM1. Microsatellites were located in promoters, introns and exons, being most of them CT dinucleotide repeats. Genetic diversity of these eight CG-derived SSR-markers was explored in 54 unrelated genotypes. Except for XTH2, high levels of polymorphism were detected: 93 alleles (mean of 13.1 sd 1.6 alleles per locus), a mean effective number of alleles (Ne) of 5.4 (sd 1.6), polymorphic information content values (PIC) from 0.617 to 0.855 and probability of Identity (PI) ranging from 0.030 to 0.151. Conclusions: This is the first report on the identification, characterization and diversity analysis of microsatellite markers located inside wood quality candidate genes (CG) from Eucalyptus globulus. This set of markers is then appropriate for characterizing genetic variation, with potential usefulness for quantitative trait loci (QTL) mapping in different eucalypts genetic pedigrees and other applications such as fingerprinting and marker assisted diversity management.","palabras_clave":"FUNCTIONAL MARKERS|GENETIC DIVERSITY|LIGNIN PATHWAY|SSR|WOOD DENSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89013,"idioma_id":4,"titulo":"Cage Effect in Poly (alkyl-methacrylate) Thin Films Studied by Nile Red Single Molecule Fluorescence Spectroscopy","resumen":"Interactions in a probe\u2013polymer cage were monitored by spectral fluctuations in the emission spectroscopy of single molecules of Nile Red in poly(alkyl methacrylate) thin films (25\u2013200 nm) in the 278\u2013323 K temperature range. Three types of emission spectra were identified. The highest emission energy spectra show small amplitude fluctuations and a very low probability of changing their spectral emission features. On the other hand, the other two types of emission profiles exchange more frequently. The fluctuations are analyzed by the complementary cumulative distribution function of spectral emission energy difference between successive spectra in a time trace. The fluctuations show three components: two of them with zero mean average and distinctly different standard deviations and a third component with much lower frequency and an amplitude absolute value of 0.13\u20130.15 eV. This amplitude is the same in all conditions, pointing to a common feature of the probe\u2013polymer cage as responsible for their presence: complex cage rearrangements, involving the carbonyl side chain of the polymer as the common actor are postulated to be the cause of these spectral fluctuations in the time range of seconds.","palabras_clave":"nile red|cage effect|single molecule spectroscopy|fluorescence|poly(alkyl-methacrylate)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89014,"idioma_id":4,"titulo":"Phospholipase D&#948; is involved in nitric oxide-induced stomatal closure","resumen":"Nitric oxide (NO) has recently emerged as a second messenger involved in the complex network of signaling events that regulate stomatal closure. Little is known about the signaling events occurring downstream of NO. Previously, we demonstrated the involvement of phospholipase D (PLD) in NO signaling during stomatal closure. PLD&#948;, one of the 12 Arabidopsis PLDs, is involved in dehydration stress responses. To investigate the role of PLD&#948; in NO signaling in guard cells, we analyzed guard cells responses using Arabidopsis wild type and two independent pld&#948; single mutants. In this work, we show that pld&#948; mutants failed to close the stomata in response to NO. Treatments with phosphatidic acid, the product of PLD activity, induced stomatal closure in pld&#948; mutants. Abscisic acid (ABA) signaling in guard cells involved H(2)O(2) and NO production, both required for ABA-induced stomatal closure. pld&#948; guard cells produced similar NO and H(2)O(2) levels as the wild type in response to ABA. However, ABA- or H(2)O(2)-induced stomatal closure was impaired in pld&#948; plants. These data indicate that PLD&#948; is downstream of NO and H(2)O(2) in ABA-induced stomatal closure.","palabras_clave":"Nitric oxide|guard cells|stomatal closure|Phospholipase D"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89015,"idioma_id":4,"titulo":"Classical Trajectory Monte Carlo Calculation of the Recoil-Ion Momentum Distribution for Positron-Impact Ionization Collisions","resumen":"We investigate ionization processes induced by positron impact on H2 by studying the momentum distributions of the receding ion. To this end, we employ classical trajectory Monte Carlo techniques. The investigation of the recoil ion momentum distribution allows us to shed new light on some known phenomena like the familiar ?electron capture to the continuum? peak of electron momentum spectroscopy, and also to unveil new structures which?up to our knowledge?have never been reported in the literature. We propose that some of these new effects represent fingerprints of a strong orientation of low-energy electrons into the direction of motion of the electron?positron centre of mass. We analyse the mechanisms that might give rise to these effects, and relate them to structures in the electron and positron momentum distributions. We also discuss how these theoretical predictions can be put to test in actual positron reaction microscopic experiments.","palabras_clave":"IONIZATION|POSITRON|RECOIL-ION|MONTECARLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89016,"idioma_id":4,"titulo":"Periodic variations in the wavelength distributions following photon interferences : analogy with electron interferences","resumen":"A new interference phenomenon is reported, which has so far not been observed with either matter or light. In a nanometer-sized version of Feynman´s famous two-slit ?thought? experiment with single electrons, the width of a quasi-monochromatic line has been found to oscillate with the detection angle. Since this experiment resembles the original double-slit experiment by Young with light (1807), photon interferences were investigated in order to determine the wavelength distribution as a function of the position in the interference field. In addition to the well-known oscillating dependence of the intensity with a succession of dark and bright fringes, a periodic dependence with respect to the detection position has also been observed for the width of the wavelength distribution, revealing a larger analogy between electron and photon interferences.","palabras_clave":"INTERFERENCE|PHOTON|ELECTRON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89017,"idioma_id":4,"titulo":"BCZT ceramics prepared from activated powders","resumen":"Ultra-fine BayCa1-y(ZrxTi1-x)O3 powders, with y = 0.89 and x = 0.10, has   been synthesized by solid state reaction route from commercial BaCO3,   CaCO3, TiO2 and ZrO2 powders using the high-energy ball milling   technique in air at room temperature. Dense BCZT ceramics were prepared   by varying the sintering conditions from green pellets obtained by   uniaxial pressing of powders calcined at 800&nbsp;C. The results of   dielectric and ferroelectric properties show that the high-energy ball   milling process is a practical and promising way to prepare BCZT   ceramics","palabras_clave":"ceramics|dielectrics| ferroelectricity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89018,"idioma_id":5,"titulo":"Hiperandrogenización prenatal en ratas y el metabolismo lipídico en la vida adulta","resumen":"El síndrome del ovario poliquístico (PCOS) es una afección de alta incidencia en mujeres en edad fértil. Si bien la etiología de la enfermedad se desconoce, se cree que la exposición a andrógenos durante la vida intrauterina generaría reprogramación fetal afectando vías endocrinas y metabólicas que, junto a alteraciones génicas y ambientales, inducirían la aparición de PCOS en etapas muy tempranas de la vida. Es por ello que se buscan marcadores tempranos del desarrollo de PCOS. Utilizando un modelo murino de hiperandrogenización prenatal (HA) recreamos dos fenotipos de PCOS: ovulatorio y anovulatorio. La HA no alteró el colesterol circulante pero disminuyó el colesterol HDL y aumentó el LDL y los triglicéridos (TG) con respecto a los controles. La relación colesterol total\/HDL como marcador de riesgo cardiovascular y la relación TG\/HDL se vieron incrementadas con respecto a los controles, resultando mayor en el grupo PCOS anovulatorio. El presente trabajo demuestra la importancia de la determinación del perfil lipídico a edades tempranas en poblaciones de riesgo (como es el caso de hijas de madres con PCOS).","palabras_clave":"SÍNDROME DE OVARIO POLIQUÍSTICO|DISLIPIDEMIA|COLESTEROL|BAJO PESO AL NACER|OBESIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89019,"idioma_id":4,"titulo":"Physicochemical and functional characterization of by-products from chia (Salvia hispanica L.) seeds of Argentina","resumen":"The objective of this study was to characterize the physicochemical and functional properties of meals (M) and fibrous fractions (FRF) of chia seeds (Salvia hispanica L.), and to compare the effect of oil extraction methods (pressing -p- and solvent extraction -s-) and sieving process on these properties. Both processes affect the physicochemical and functional properties of residual meals and their corresponding fibrous fractions. Mp and FRFp showed a significantly higher residual oil content than Ms and FRFs (11.39, 10.85, 0.21 and 0.21&nbsp;g\/100 dry base, respectively). The sieving process of both meals allowed to obtain fibrous fractions with a significant increase of crude fiber (27.57, 32.84, 23.81 and 28.35&nbsp;g\/100&nbsp;g in Ms, FRFs, Mp and FRFp, respectively), and a marked decrease of protein content (41.36, 35.32, 35.00 and 33.74&nbsp;g\/100&nbsp;g in Ms, FRFs, Mp and FRFp, respectively). Total dietary fiber and their respective components (soluble and insoluble dietary fiber) were significantly higher in FRF. All the samples exhibited a high antioxidant activity due to the presence of phenolic compounds and tocopherols in the case of Mp and FRFp. Ms and FRFs presented a better oil-holding capacity, organic molecule absorption capacity, emulsifying activity and emulsion stability than Mp and FRFp, and allowed to achieve more stable emulsions. FRFs showed the highest values of water absorption and adsorption capacity.","palabras_clave":"by-product of chia seeds|functional properties|physicochemical properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89020,"idioma_id":5,"titulo":"Control biológico in vitro por bacterias ácido lácticas aisladas de residuos de cervecería","resumen":"Los residuos de cervecería son suplementos de bajo costo y de fácil disponibilidad, sin embargo, el alto contenido de humedad los hace susceptibles a la degradación fúngica y al desarrollo de microorganismos patógenos. Las bacterias ácido lácticas (BAL) se encuentran formando parte de la microbiota de los granos de cebada, de manera tal, que podrían contribuir en la calidad y seguridad tanto de la malta como de los productos derivados. El objetivo de este estudio fue determinar la presencia BAL, especies fúngicas de Aspergillus sección Flavi, Listeria monocytogenes e incidencia de AFB1 en residuos de cervecería, y evaluar in vitro el efecto antifúngico y antiaflatoxicogénico de las BAL. El análisis de los residuos de cervecería mostró que, en general, los recuentos de BAL fueron elevados durante todos los períodos analizados, sin embargo, el recuento de A. sección Flavi, L. monocytogenes e incidencia natural de AFB1 fue variable. El hallazgo de L. monocytogenes es el primero informado en Argentina en este tipo de sustrato. Lactobacillus coryniformis subsp. coryniformis L47 y Lactobacillus cellobiosus L56 fueron las cepas más efectivas en inhibir el crecimiento y la producción de AFB1 de todas las cepas de A. sección Flavi ensayadas in vitro. Futuros estudios con estas cepas de BAL podrían realizarse para demostrar su efectividad in situ en estos sustratos alternativos destinados a la producción animal, como así también evaluar in vitro sus propiedades antilisteria.","palabras_clave":"BACTERIAS ÁCIDO LÁCTICAS|A. SECCION FLAVI|LISTERIA MONOCYTOGENES|AFLATOXINA B1|BIOCONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89021,"idioma_id":4,"titulo":"Habitat selection of Molina´s hog-nosed skunk in relation to prey abundance in the Pampas grassland of Argentina","resumen":"We radiotracked 16 (6 males, 10 females) adult Molina\u2019s hog-nosed skunks (Conepatus chinga) to examine habitat selection using compositional analysis at 2 spatial scales in a protected area and a landscape fragmented by agriculture. To aid in understanding the habitat use of skunks, the abundance of invertebrates was estimated in each habitat. Habitat use and selection varied between the two study sites. Skunks selected habitat at landscape level but not at home range level in the protected area. In the cropland area skunks showed overall habitat selection at both scales, although at landscape level we did not detect a significant ranking of habitats. In both sites, when we found a significant selection grassland patches ranked first. Although this habitat does not reach 10% of the total area, it presented the highest abundance of Coleoptera. Because Coleoptera ar 31 e the main prey item of this mephitid, these results support the hypothesis that habitat selection in C. chinga is highly related to food availability. We conclude that the preservation of grassland patches may be essential formanaging C. chinga populations in the highly human-modified landscapes of the Pampas.","palabras_clave":"Compositional analysis|Conepatus chinga|Mephitidae|Radiotelemetry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89022,"idioma_id":4,"titulo":"Preferential Formation of the Different Hydrogen Bonds and Their Effects in Tetrahydrofuran and  Tetrahydropyran Microhydrated Complexes","resumen":"The role of cycloether-water (c-w) andwater-water (w-w) hydrogen bonds (H-bonds) on &nbsp;the stability of thetetrahydrofuran (THF)\/(H2O)n and thetetrahydropyran (THP)\/(H2O)n complexes with n=1-4 was investigated herein using the density functional and ab initio methodsand the atoms in molecules theory. Geometry optimizations for these complexeswere carried out with various possible initial guess structures. It wasrevealed that the major contributions of the mono and dihydrated complexes camefrom c-w H-bonds. A competition between c-w and w-w H-bonds contribution wasobserved for trihydrated complexes. For most of tetrahydrated complexes, theinter-water H-bonds provided the greatest contribution, whereas the c-wcontributions were small but not negligible. It was confirmed that to produce a hydrophobichydration of cycloethers, the C-H···Ow H-bond shouldbeassociated witha network of H-bonds that connects both portionsof the solute, throughthe formation of a bifunctionalH-bond. A linear correlation is obtained for the sum of electron density at thebond critical points (rb) with the interaction energy (DE) and with the solute-solventinteraction energy (DEs-w) of the microhydrated complexes. Inaddition, a new way to estimate the energetic contribution as well as thepreferential formation of the different H-bonds based completely on rbwas found. Even more, it allows to differentiate the contribution from c?winteractions in both hydrophilic and hydrophobic contributions, it is thereforea useful tool for studying the hydration of large biomolecules. Theanalysis of the modifications in the atomic and group properties brought aboutby successive addition of H2O molecules allowedto pinpoint the atoms or molecular groups that undergo the greatest changes inelectron population and energetic stabilization. It was identified that the remarkable stabilization of the water oxygen atoms is crucial forthe stabilization of the complexes.","palabras_clave":"HYDROPHILIC AND HYDROPHOBIC HYDRATION|BIFUNCTIONAL HBOND|CHARGE DENSITY, |ATOMIC AND GROUPS PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89023,"idioma_id":4,"titulo":"Microsolvation of morpholine, a bidentate base. The importance of cooperativity","resumen":"                            The structure, relative energies and bonding in morpholine(water)n  (n = 1-4) clusters have beeninvestigated at the  B3LYP\/6-311+G(3df,2p)\/\/B3LYP\/6-311+G(d,p) level of theory. Cooperative effects  have been analyzed through the use of structural, energetic and electron  density indexes.&nbsp; Our analysis shows that these effects are crucial to  trace the relative stability of the complexes formed. In all cases water  molecules prefer to self-associate forming chains in which each individual  molecule behaves as a HB donor and HB acceptor. The chain so formed behaves in  turn as HB donor and HB acceptor with respect to morpholine, being the most  stable arrangements those in which the NH group of morpholine behaves  simultaneously as HB donor and HB acceptor. Higher in energy lie complexes in  which the HB acceptor continues to be the NH group, but the HB donor is a CH group,  or alternative structures in which the HB acceptor is the ether-like oxygen of  morpholine and the HB donor its NH group.&nbsp; Cooperativity increases with  the number of solvent molecules, but there is a clear attenuation effect. Thus,  whereas the additive interaction energy on going from dihydrated to trihydrated  species increases by a factor of 3, this increase is about half on going from  trihydrated to tetrahydrated complexes                          ","palabras_clave":"DENSITY FUNCTIONAL THEORY|HERTEROCYCLIC COMPOUNDS|HYDROGEN BOND|MICROSOLVATION|QUANTUM THEORY OF ATOMS IN MOLECULES (QTAIM)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89024,"idioma_id":5,"titulo":"DIVERSIDAD DE VERTEBRADOS ACUÁTICOS DE TRES HUMEDALES URBANOS DE LA CIUDAD DE BUENOS AIRES","resumen":"The urban wetlands are sites of high biodiversity that are under a great anthropogenicpressure. In the city of Buenos Aires, one of the more important areas of recreation is constituted byParque Tres de Febrero (well-known as like \u201CBosques de Palermo\u201D), that conforms a green zone of 25 ha. Inthis area there are artificial wetlands of diverse physical characteristics. In the present work, the goal isto determine vertebrate\u2019s diversity in these urban aquatic enviroments in order to evaluate the degree ofimpact of the recreational activity on the conservation of the vertebrates associated to the water bodies.The study was carried out in three artificial lagoons included in the park: Regatas, Rosedal and Planetario.Altogether, seventeen species of fish (Prochilodus lineatus, Oligosarcus jenynsii, Cheirodon interruptus, Bryconamericusiheringii, Hoplias malabaricus, Hypostomus commersoni, Rhamdia quelen, Pimelodus albicans, Pimelodusmaculatus, Cyprinus carpio carpio, Cnesterodon decemmaculatus, Gambusia affinis, Jenynsia multidentata, Synbranchusmarmoratus, Australoheros facetus, Gymnogeophagus meridionalis and Crenicichla scottii), eighteen species ofbirds (Podiceps rolland, Podilymbus podiceps, Podiceps major, Phalacrocorax olivaceus, Ardea alba, Egretta thula,Butorides striatus, Nycticorax nycticorax, Anas georgica, Anas platyrhynchos, Anas platyrhynchos domesticus, Anseranser, Cairina moschata, Netta peposaca, Aramus guarauna, Fulica armillata, Fulica leucoptera and Chloroceyleamazona), three species of turtles (Phrynops hilarii, Trachemys scripta elegans and Trachemys venusta) and onespecies of mammal were registered (Myocastor coipo). Among these species, eight are introduced: two fishes(Cyprinus carpio carpio and Gambusia affinis), two turtles (Trachemys scripta elegans and Trachemys venusta) andfour birds (Anas platyrhynchos, Anas platyrhynchos domesticus, Anser anser and Cairina moschata). Regatas wasthe site with greater diversity of fishes (n=17) that represents a 10.43% of Río de la Plata\u2019s ichthyofauna(n=163). This site lodges a 13% of the bird species associated to registered water bodies in the City ofBuenos Aires (n=107). When comparing the specific richness among lagoons, we found high similaritybetween Regatas and Planetarium. Also, both sites presented the greatest specific richness of fish duringthe months of January and February. From this preliminary study it was possible to describe and to differentiateeach lagoon by its fauna and physical characteristics, and also it constitutes the base to continuewith further studies of communities which allow the development of the necessary guidelines of handlingfor the protection of Lagos Tres de Febrero.","palabras_clave":"HUMEDALES URBANOS|BIODIVERSIDAD|VERTEBRADOS ACUATICOS|BUENOS AIRES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89025,"idioma_id":4,"titulo":"Selenized garlic: a future prospect or already a current functional food?","resumen":"La aplicación de selenio en forma foliar permitió aumentar los niveles de este elemento en los bulbos de ajo","palabras_clave":"Allium sativum|Selenio |Alimentos funcionales|salud humana"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89026,"idioma_id":5,"titulo":"LAS LÓGICAS DE OCUPACIÓN DEL ESPACIO URBANO. UN ESTUDIO DE REALIDADES CONTRAPUESTAS. EL CASO DE LAS URBANIZACIONES CERRADAS Y VILLAS MISERIA EN YERBA BUENA, GRAN SAN MIGUEL DE TUCUMÁN","resumen":"Desde el punto de vista socio-espacial una de las transformaciones más importantes acaecidas en la estructura urbana del Gran San Miguel de Tucumán -GSMT-, desde la década del 70`, ha sido el cambio en los patrones de expansión. A partir de esto el objetivo principal de este artículo radica en estudiar y comparar las lógicas de ocupación del espacio urbano a partir del análisis de las Villas Miseria -VM- y las Urbanizaciones Cerradas -UC- en el Municipio Yerba Buena -MYB-, teniendo en cuenta la participación de este municipio en el proceso de conformación del aglomerado GSMT. Se toma como punto de partida la década de 1970 momento en el cual se produjo una fuerte expansión de la ciudad hacia su periferia caracterizada, principalmente, por el aumento de las VM junto con el surgimiento de la primera UC. La expansión urbana presenta un crecimiento exponencial de las UC mientras que la superficie ocupada por las VM prácticamente no se modificó.  En el MYB el contraste más significativo está representado por la coexistencia de UC y VM. Las UC son una tendencia que aumenta rápidamente y conducen la expansión ocupando grandes extensiones de tierra. Por el contrario el incremento de las VM es escaso teniendo en cuenta su proliferación en el resto del GSMT. No obstante muchas de estas UC y VM se encuentran localizadas muy próximas entre sí pero la distancia socio-económica que separa a sus habitantes es cada vez más amplia, acentuando la brecha entre ambos grupos.","palabras_clave":"Lógicas de Ocupación|Urbanizaciones Cerradas|Villas Miseria|Yerba Buena"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89027,"idioma_id":4,"titulo":"E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation","resumen":"Central to the maintenance of genomic integrity is the cellular DNA damage response. Depending on the type of genotoxic stress and through the activation of multiple signaling cascades, it can lead to cell cycle arrest, DNA repair, senescence, and apoptosis. p19INK4d, a member of the INK4 family of CDK inhibitors, plays a dual role in the DNA damage response, inhibiting cell proliferation and promoting DNA repair. Consistently, p19INK4d has been reported to become upregulated in response to UV irradiation and a great variety of genotoxic agents. Here, this induction is shown to result from a transcriptional stimulatory mechanism that can occur at every phase of the cell cycle except during mitosis. Moreover, evidence is presented that demonstrates that E2F1 is involved in the induction of p19INK4d following UV treatment, as it is prevented by E2F1 protein ablation and DNA-binding inhibition. Specific inhibition of this regulation using triplex-forming oligonucleotides that target the E2F response elements present in the p19INK4d promoter also block p19INK4d upregulation and sensitize cells to DNA damage. These results constitute the first description of a mechanism for the induction of p19INK4d in response to UV irradiation and demonstrate the physiological relevance of this regulation following DNA damage.","palabras_clave":"E2F1|p19INK4d|DNA DAMAGE RESPONSE|UV IRRADIATION|TRANSCRIPTIONAL REGULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89028,"idioma_id":4,"titulo":"Monoglyceride synthesis by glycerolysis of methyl oleate on MgO: Catalytic and DFT study of the active site","resumen":"The synthesis of monoglycerides by glycerolysis of methyl oleate, a fatty acid methyl ester (FAME), was efficiently promoted on strongly basic MgO. The chemical nature of the base sites responsible for the catalytic activity was investigated, both experimentally and by density functional theory (DFT). MgO catalysts stabilized at different temperatures were used to control the distribution of surface base sites. The nature, density and strength of the catalyst base sites were characterized by TPD and FTIR of CO2. Catalytic results suggested that the synthesis of monoglycerides was promoted mainly on strongly basic low coordination O2- surface sites.&nbsp; The molecular modeling of glycerol (Gly) and FAME adsorptions was carried out using terrace, edge and corner sites for representing the MgO surface. Results indicated that Gly was more strongly adsorbed than FAME. Dissociative chemisorption of Gly with O-H bond breaking was favored on low coordination O2- surface sites such as those on edges, in agreement with the experimental results. Thus, the proton abstraction from the OH groups of Gly, a necessary step in the reaction mechanism, would take place on unsaturated oxygen anions and the resulting glyceroxides would react with weakly adsorbed FAME molecules.","palabras_clave":"GLYCEROL|MONOGLYCERIDE|DFT|BASE CATALYSIS|GLYCEROLYSIS|FATTY ACID METHYL ESTER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89029,"idioma_id":5,"titulo":"Evaluación de estrés oxidativo en juveniles de Prochilodus lineatus expuestos a cipermetrina","resumen":"Las aplicaciones de grandes cantidades de pesticidas en zonas agrícolas pueden encontrar su camino en los cursos de agua, lo que produce un impacto adverso en la biota acuática. En este estudio se utilizaron biomarcadores de daño oxidativo, peroxidación lipídica (TBARS) y defensas antioxidantes: Catalasa (CAT) y Glutation reducido (GSH), en tejido hepático de Prochilodus lineatus expuesto in vivo a cipermetrina (0,300, 0,150, 0,075 y 0,000 µg\/l) por 96h. Los resultados no mostraron diferencias significativas en las concentraciones crecientes de cipermetrina ensayadas con respecto al grupo control al evaluar TBARS y GSH (p>0,05 en ambos casos). Para CAT, se encontró una disminución estadísticamente significativa (p<0,05) a  las concentraciones de 0,150 y 0,300 µg\/l de cipermetrina. De los marcadores de daño oxidativo utilizados, CAT demostró ser el  más eficaz para monitorear in vivo los efectos de cipermetrina en Prochilodus lineatus, siendo este un organismo sensible.","palabras_clave":"PROCHILODUS LINEATUS|ESTRÉS OXIDATIVO|CIPERMETRINA|TEJIDO HEPÁTICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89030,"idioma_id":4,"titulo":"The Tell-Tale Heart: heart rate fluctuations index objective and subjective events during a game of chess","resumen":"During a decision making process, the body changes. These somatic changes have been related to specific cognitive events and also have been postulated to assist decision making indexing possible outcomes of different options. We used chess to analyze heart rate (HR)  modulations on specific cognitive events. In a chess game, players have a limited time- budget to make about 40 moves (decisions) that can be objectively evaluated and retrospectively assigned to specific subjectively perceived events, such as setting a goal and  the process to reach a known goal. We show that HR signals events: it predicts the conception of a plan, the concrete analysis of variations or the likelihood to blunder by fluctuations before to the move, and it reflects reactions, such as a blunder made by the opponent, by fluctuations subsequent to the move. Our data demonstrate that even if HR  constitutes a relatively broad marker integrating a myriad of physiological variables, its dynamic is rich enough to reveal relevant episodes of inner thought.","palabras_clave":"decision-making |cognitive processes |problem solving |heart rate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89031,"idioma_id":4,"titulo":"Antioxidant capacity without DNA damage of aqueous extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae)","resumen":"The aim of the present work was to make a contribution to the knowledge of aqueous extracts of Lippia turbinata and Aloysia citriodora (Verbenaceae; infusion and decoction) in relation with the establishment of its antioxidant activity and lack of DNA damage, for its potential use in therapeutics. The cytogenotoxic profile was evaluated through genotoxic biomarkers such as mitotic index, cellular proliferation kinetics, sister chromatid exchanges, single-cell gel electrophoresis assay, and micronucleus test in human peripheral blood lymphocyte cultures. No statistical differences were found (P &gt; .05) between control and exposed cultures, even between both aqueous extracts. The total antioxidant capacity was shown to be higher in the decoction than in the infusion and both aqueous extracts protected against protein carbonylation and lipid peroxidation, the decoction being moreefficient than the infusion (P &lt; .005). These results suggest the safe use of these medicinal plants as chemoecologic agents in therapeutics.","palabras_clave":"biomarkers|antioxidant activity|Verbenaceae|Aloysia citriodora|Lippia turbinata"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89032,"idioma_id":5,"titulo":"Reseña de 'Historia de las clases populares en la Argentina. Desde 1516 hasta 1880'","resumen":"Se reseñó el libro 'Historia de las clases populares en la Argentina. Desde 1516 hasta 1880' de Gabriel Di Meglio.","palabras_clave":"Reseña |Clases Populares|Historia Colonial|Siglo XIX"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89033,"idioma_id":4,"titulo":"Maltooligosaccharides production catalysed by cyclodextrin glycosyltransferase from Bacillus circulans DF 9R in batch and continuous operation","resumen":"Cyclodextrin glycosyltransferase catalyses the synthesis of cyclodextrins from starch by intramoleculartransglycosylation. However, under certain conditions, the reaction can be directed towards the productionof linear dextrins, suppressing the synthesis of cyclodextrins. Thus, the starch acts as donormolecule and low molecular weight oligosaccharides act as acceptors in intermolecular transglycosylationreactions. In this paper the optimal conditions to transform starch into maltooligosaccharideswere determined employing glucose and maltose as acceptors and cyclodextrin glycosyltransferase fromBacillus circulans DF 9R as catalyst. Maltooligosaccharides production was optimised in a batch processreaching a yield of 60%. Besides, a continuous process was developed in a membrane reactor, increasingthe yield to 72% and multiplying eight times the productivity. In this way, it was possible to obtain ahigh purity product with higher efficiency, using a cyclodextrin glycosyltransferase. This is even moreadvantageous when compared with the processes currently used in industry which uses three enzymes.","palabras_clave":"Cyclodextryn glycosyltransferase|Bacillus circulans|Maltooligosaccharides|Starch conversion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89034,"idioma_id":4,"titulo":"Effect of fasting on the structure and function of the gastrointestinal tract of house sparrows (Passer domesticus)","resumen":"Abstract  Starvation is a condition that often affects animals in nature. The gastrointestinal tract is the organ system displaying the most rapid and dramatic changes in response to nutrient deprivation. To date, little is known about starvation phases and effects on the organ morphology and digestive function in small passerine birds. In this study, we determined the phases of starvation and examined the effect of final stage of starvation in the organ morphology and, intestinal histology and enzymatic function in the small intestine. Our results show the three phases of the classical model of fasting in a shorter period of time. The mass of heart, pancreas, stomach, small intestine and liver of long-term fasted birds was reduced between 20 and 47%. The mass decrease in small intestine was correlated with reduction in small intestinal histology: perimeter, mucosal thickness, villus height and width. In contrast, the enzyme activity of sucrase isomaltase and aminopeptidase-N in enterocytes, all expressed per &#956;g of protein, was higher in long-term fasted birds than fed animals. This suggest that, while autophagy of digestive organs is induced by starvation, consistent with phenotypic plasticity, the activity of sucrase?isomaltase and aminopeptidase-N remains high, probably as an anticipatory strategy to optimize digestion at re-feeding time.","palabras_clave":"STARVATION|ORGAN|HISTOLOGY|PASSERINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89035,"idioma_id":4,"titulo":"Phylogeny of the Paniceae (Poaceae: Panicoideae): integrating plastid DNA sequences and morphology into a new classification","resumen":"Included in the PACMAD clade of the family Poaceae (Panicoideae, Arundinoideae, Chloridoideae, Micrairoideae, Aristidoideae,Danthonioideae), the tribe Paniceae s.l. is one of the largest tribes of the subfamily Panicoideae, with more than 2000 species. This tribecomprises a huge morphological, cytological and physiological diversity represented by different inflorescence types, several basicchromosome numbers, and at least four major photosynthetic pathways. The tribe Paniceae has been the subject of molecular studiesthat have confirmed its paraphyly: two major clades were recognized based on their basic chromosome numbers (x = 9, x = 10). Thex = 10 Paniceae clade is sister to the Andropogoneae?Arundinelleae s.s. clade (x = 10), while the combined x = 10 clade is sister tothe x = 9 clade that contains the remaining genera of Paniceae. As a result of a recent realignment within the tribe in terms of thephylogenetic position of minor and major Paniceae genera, a reanalysis of the whole sampling is performed and new underrepresentedtaxa are discussed. A total of 155 genera, currently considered within subfamily Panicoideae, are represented here by almost all generaof Paniceae s.l., representatives of Andropogoneae and Arundinelleae s.s., and the endemic and small tribe Steyermarkochloeae; wealso included specimens of subfamilyMicrairoideae, tribes Isachneae and Eriachneae. The sampling includes as outgroups 18 genera ofthe PACMAD clade (excluding Panicoideae) and four genera from the BEP clade (Bambusoideae, Ehrhartoideae, Pooideae), rootingwith Bromus inermis. A matrix with 265 taxa based on the combined evidence from ndhF plastid sequences (2074 bp) and 57morphological characters was subjected to parsimony analyses. Jackknife resampling was used to calculate group support. Most cladesare characterized by morphological, cytological, anatomical, and\/ or physiological characters. Major tribal changes are based on thebasic chromosome number; the pantropical x = 9 clade is here recognized as Paniceae s.s., while the American x = 10 Paniceae s.l. isrestricted to the reinstated tribe Paspaleae. The optimization of the photosynthetic pathway for the Paspaleae?Andropogoneae?Arundinelleae s.s. clade, including the monotypic Reynaudia, shows a plesiomorphic C4 state while the ancestral state for Paniceae s.s. isambiguous. If Reynaudia were not included or placed elsewhere, the ancestral photosynthetic pathway for both the Paspaleae?Andropogoneae?Arundinelleae s.s. clade and the Paniceae s.s. would be unambiguously C3. In order to explore character evolutionfurther, the morphological characters were mapped onto one of the most parsimonious trees. A relationship between photosyntheticpathways and inflorescence morphology is suggested here for the first time. Based on the optimization of morphological characters andadditional data, we propose names for almost all inner clades at the rank of subtribe with a few groups as incertae sedis. With thisextensive sampling, we resolved the phylogenetic relationships and the assignation of synapomorphies, and improved the support insubtribe sorting; consequently a robust circumscription of the tribe Paniceae s.l. is proposed.","palabras_clave":"PANICEAE|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89036,"idioma_id":4,"titulo":"Colonization and yield promotion of tomato by Gluconacetobacter diazotrophicus","resumen":"Gluconacetobacter diazotrophicus is a N2-fixing bacterium originally associated with sugarcane and considered a Plant Growth Promoting Bacteria (PGPB) for diverse crops. Aiming to find PGPB for horticultural species, tomato seedlings were inoculated with G. diazotrophicus to test its ability to colonize and to evaluate whether it can enhance fruit production. Tomato seedlings were inoculated with G. diazotrophicus PAL 5 and UAP 5541\/pRGS561 (containing the marker gene gusA) under gnotobiotic conditions. In greenhouse experiments tomato seedlings were only inoculated with G. diazotrophicus PAL 5. Colonization was monitored by plating bacterial suspensions from homogenized tissues and by microscopic localization of bacteria after staining with gus substrate. Tomato yields were determined quantifying total tomato production throughout the crop in two different seasons. Root and stems endophytic population was higher than 4.0 log CFU g-1 fresh weight. Microscopic localization showed colonizing bacteria in sites of emergence of lateral roots, root hairs, and stomata. Inoculated plants significantly increased both number and weight of fruit production as compared to non-inoculated controls. These results show the ability of G. diazotrophicus to stimulate fruit production of tomato plants. ","palabras_clave":"Endophytes|PGPR|Inoculation|Gluconacetobacter diazotrophicus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89037,"idioma_id":4,"titulo":"Aggregation of non-polar solutes in water at different pressures and temperatures: The role of hydrophobic interaction","resumen":"Debido a la importancia de la interacción hidrófobica en el plegamiento de proteínas, hemos estudiado el efecto de la presión y la temperatura en las transiciones de fase de solutos no polares en agua y asi de este modo abordamos su solubilidad. Utilizamos para este estudiola tecnica de dinámica molecular. Los principales resultados son: (1) En un cierto rango, la temperatura induce la agregación de las partículas de Lennard-Jones en agua, y (2) la presión induce la desagregación de los grupos conformados. A partir de los datos simulados, una obtuvimos la curva de coexistencia para el sistema binario, en la que se observa una temperatura crítica a 383 ± 9 K y una presion critica a 937± 11 bar. Los resultados concuerdan con la evidencia experimental para mezclas de hidrocarburos en agua y para el desplegamiento de proteínas.","palabras_clave":"hydrophobic interaction|molecular dynamics|water structure|SPC\/E"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89038,"idioma_id":4,"titulo":"Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction","resumen":"Aim. To test the potential role of PPAR&#947; in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg\/Kg BW\/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content\/expression, and leptin release by isolated adipocytes incubated with di&#64256;erent concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these e&#64256;ects were signi&#64257;cantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased signi&#64257;cantly in FRD rats, those of insulin receptor-substrate (IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD e&#64256;ects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPAR&#947; would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction.&nbsp;","palabras_clave":"ADIPOKINES|EXPERIMENTAL METABOLIC SYNDROME|ADIPOCYTES|INSULIN SIGNALLING|LIPIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89039,"idioma_id":4,"titulo":"The nuclear receptor coactivator RAC3 inhibits autophagy","resumen":"RAC3 is an oncogene naturally overexpressed in several tumors.Besides its role as coactivator, it can exert several protumoralcytoplasmic actions. Autophagy was found to act either as atumor suppressor during the early stages of tumor development,or as a protector of the tumor cell in later stages under hypoxicconditions. We found that RAC3 overexpression inhibits autophagywhen induced by starvation or rapamycin and involvesRAC3 nuclear translocation-dependent and -independent mechanisms.Moreover, hypoxia inhibits the RAC3 gene expressionleading to the autophagy process, allowing tumor cells to surviveuntil angiogenesis occurs. The interplay between RAC3, hypoxia,and autophagy could be an important mechanism for tumorprogression and a good target for a future anticancer therapy.","palabras_clave":"Autophagy|RAC3|Hypoxia|Tumoral development"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89040,"idioma_id":4,"titulo":"Magnetic studies and elemental analysis of river sediments: A case study from the Ponnaiyar River (Southeastern India)","resumen":"Abstract The Ponnaiyar River is one of the largest rivers of the Tamil Nadu state (India), &#64258;owing a distance of 430 km from its point of origin to the sea. This work contributes with new data of magnetic and elemental composition of river sediments, and improves the knowledge obtained by preliminary and previous studies of rivers from Southeastern India. Magnetic susceptibility, anhysteretic and isothermal remanent magnetization and chemical determinations (major and trace metals) were measured. Magnetic results reveal the predominance of magnetite-like mineral with magnetic grain size variations along the river and in depth. Most of the uppermost samples have the major presence of trace metals and higher values of magnetic concentration. Magnetic and chemical variables were also analysed as potential pollution indicators using multivariate statistical techniques: canonical correlation and fuzzy c-means clustering analyses, which con&#64257;rmed the existence of relationships, but not in a simple way, between magnetic and chemical variables. Furthermore, fuzzy analysis allows classifying the data in different well-differentiated groups regarding the trace metal load, concentration and feature-dependent parameters. The most polluted samples show high concentration of trace elements and magnetic carriers, softer and coarser magnetic minerals; on the contrary, the unpolluted samples (from the deepest sediments) have the opposite characteristics.","palabras_clave":"ENVIRONMENTAL MAGNETISM|MAGNETIC SUSCEPTIBILITY|FUZZY METHOD|POLLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89041,"idioma_id":4,"titulo":"Nmag_2608, an extracellular ubiquitin-like domain containing protein from the haloalkaliphilic archaeon Natrialba magadii","resumen":"Ubiquitin-like proteins (Ubls) and ubiquitin like domain-containing proteins (Ulds) found in both eukaryotes and prokaryotes display an ubiquitin fold. We previously characterized a 124-amino acid polypeptide  (P400) from the haloalkaliphilic archaeon Natrialba magadii having structural homology with ubiquitin family proteins. The reported N. magadii?s genome allowed the identification of the Nmag_2608 gene for the protein containing P400, which belongs to specific orthologs of halophilic organisms. It was found that Nmag_2608 has an N-terminal signal peptide with a lipobox motif characteristic of bacterial lipoproteins. Also, it presents partial identity with the ubiquitin-like domain-containing proteins, soluble ligand binding b-grasp proteins. Western blots and heterologous expression tests in E. coli evidenced that  Nmag_2608 is processed and secreted outside the cell, where it could perform its function. The analysis of Nmag_2608 expression in N. magadii´s cells suggests a co-transcription with the adjoining Nmag_2609 gene encoding a protein of the cyclase family. Also, the transcript level  decreased in cells grown in low salinity and starved. To conclude, this work reports for the first time an extracellular archaeal protein with an ubiquitin-like domain.","palabras_clave":"Halophillic archaea|Natrialba magadii|Ubiquitin like domains|Extracellular proteins|Protein-subtrate interaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89042,"idioma_id":4,"titulo":"Toxicity persistence in runoff and soil from experimental soybean plots following insecticide applications","resumen":"Persistence of toxicity in runoff water and soil was investigated in experimental soybean plots subjected to successive runoff eventsfollowing pesticide application. Runoff events were produced by irrigation using a sprinkler system. The pesticides applied werecypermethrin and endosulfan, which are widely used in soy production in Argentina. Toxicity tests were performed on two abundantcomponents of the regional fauna, the amphipod Hyalella curvispina and the fish Cnesterodon decemmaculatus. Runoffs from twopesticide applications were assayed at different stages of the growing season: an early application when the soil was almost bare anda late one close to harvest, when the ground was covered by vegetation and just before soy leaves fell. Toxicity to H. curvispina inrunoff ceased almost one month after the early application of the two pesticides, while it persisted for over three months after the lateapplication. Soil toxicity to H. curvispina and runoff toxicity to C. decemmaculatus followed the same pattern. Higher temperaturesand solar radiation are likely to have enhanced insecticide degradation after the early application. Lower temperatures and solarradiation in combination with increased organic matter from litter probably contributed to the longer persistence of toxicity recordedafter the late application, as compared with the early application. Cypermethrin caused no mortality to C. decemmaculatus after theearly application, while endosulfan toxicity persisted for almost four months after the late one.","palabras_clave":"toxicidad|persistencia|escorrentía superficial|cipermetrina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89043,"idioma_id":4,"titulo":"Cypermethrin, Chlorpyrifos and Endosulfan Toxicity to Two Non-Target Freshwater Organisms","resumen":"Pesticide consumption has increased considerably overthe last decades in the Argentine Pampa. The persistenceof toxicity of three commonly used insecticides to tworegionally abundant organisms was assayed at environmentallyrealistic conditions. To simulate a runoff event,insecticides were added to aquariums containing water andsediment collected from a representative stream. The toxicityof insecticides formulations containing cypermethrin,chlorpyrifos and endosulfan to the amphipod Hyalella curvispinaand the fish Cnesterodon decemmaculatus wasassessed with laboratory bioassays conducted on watertaken from the aquariums immediately after pesticide additionand every 2 to 3 days thereafter until toxicity ceased.Endosulfan did not cause mortality to H. curvispina at anominal concentration of 1 &#956;g\/L. Cypermethrin and chlorpyrifoscaused 100% mortality immediately after applicationat this concentration. Toxicity ceased 4 days afteraddition of chlorpyrifos, and 9 days after addition of cypermethrin,resulting in a 50% lethal time of 3 and 4 days,respectively.C. decemmaculatus demonstrated no mortality at 1 &#956;g\/Lnominal concentration of the formulated insecticides assayed.At a dose of 5&#956;\/L, no mortality was exhibited forcypermethrin and chlorpyrifos, while endosulfan produced100% mortality immediately after application, but no significanttoxicity 2 days after application.Present results suggest short persistence of toxicity ofthe commonly used insecticide formulations in Pampasicsurface waters.","palabras_clave":"cipermetrina|endosulfan|clorpirifos|toxicidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89044,"idioma_id":4,"titulo":"Assessment of biotic integrity of the coastal freshwater tidal zone of a temperate estuary of South America through multiple indicators","resumen":"The aim of this study was to propose an index (the IBIRP: Index of Biotic Integrity for the Río de la Plata) formulated from a minimum of information-rich metrics related to biological integrity for evaluation of the coastal freshwater tidal zone of the Río de la Plata estuary. A total of 23 sites were selected along 170 km of shoreline (34º 27´ 10' S, 58º 30´ 21' W and 35° 23´ 28' S, 57° 08´ 50' W), being influenced by different land uses. We explored 36 biotic descriptors (designated candidate metrics), each of which is considered as an environmental indicator, and selected four metrics: two related to phytoplankton assemblage (planktonic cyanobacterial density and phytoplanktonic total density) and two linked to benthic assemblages, the diatoms (percent most tolerant taxa) and the invertebrates (percent Tanaidacea). The metrics that were chosen to integrate the IBIRP provide valuable information about the biotic integrity both in terms of time and space. The multimetric index can assume values between 0 (very bad status) and 10 (very good status). The IBIRP correlated significantly with the second (p <0.001) and fourth (p <0.01) factors of the Factor Analysis -those being related to variables indicative of eutrophication and organic pollution. This index constitutes an approach that is capable of reflecting the anthropogenic impacts produced along the coast of the Río de la Plata, with the inherent flexibility of being subject to modification and ultimate validation for estuaries of similar characteristics.","palabras_clave":"BIOTIC INTEGRITY INDEX|FRESHWATER TIDAL ZONE|ESTUARY|PHYTOPLANCTON-BENTHIC INVERTEBRATES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89045,"idioma_id":4,"titulo":"The need for speed: testing acceleration for estimating animal travel rates in terrestrial dead-reckoning systems","resumen":"Numerous methods are currently available to track animal movements.   However, only one of these, dead-reckoning, has the capacity to provide   continuous data for animal movements over fine scales. Dead-reckoning   has been applied almost exclusively in the study of marine species, in   part due to the difficulty of accurately measuring the speed of   terrestrial species. In the present study we evaluate the use of   accelerometers and a metric known as overall dynamic body acceleration   (ODBA) as a proxy for the measurement of speed for use in   dead-reckoning. Data were collated from previous studies, for 10 species   locomoting on a treadmill and their ODBA measured by an attached data   logger. All species except one showed a highly significant linear   relationship between speed and ODBA; however, there was appreciable   inter- and intra-specific variance in this relationship. ODBA was then   used to estimate speed in a simple trial run of a dead-reckoning track.   Estimating distance travelled using speed derived from prior calibration   for ODBA resulted in appreciable errors. We describe a method by which   these errors can be minimised, by periodic ground-truthing (e.g., by GPS   or VHF telemetry) of the dead-reckoned track and adjusting the   relationship between speed and ODBA until actual known positions and   dead-reckoned positions accord.","palabras_clave":"DEAD RECKONING|OVERALL DYNAMIC BODY ACCELERATION|TELEMETRY|TERRESTRIAL LOCOMOTION|TRACK TORTUOSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89046,"idioma_id":4,"titulo":"The &#946;-Scaffold of the LOV Domain of the Brucella Light-Activated Histidine Kinase Is a Key Element for Signal Transduction","resumen":"Light-Oxygen-Voltage (LOV) domains are blue-light-activated signaling modules present in a wide range of sensory proteins. Among them, the histidine kinases are the largest group in prokaryotes (LOV-HK). Light modulates the virulence of the pathogenic bacteria Brucella abortus through LOV-HK. One of the striking characteristic of Brucella LOV-HK is the fact that the protein remains activated upon light sensing, without recovering the basal state in the darkness. In contrast, the light state of the isolated LOV domain slowly returns to the dark state. To gain insight into the light activation mechanism, we have characterized by X-ray crystallography and solution NMR spectroscopy the structure of the LOV domain of LOV-HK in the dark state and explored its light-induced conformational changes. The LOV domain adopts the &#945;\/&#946; PAS (PER-ARNT-SIM) domain fold and binds the FMN cofactor within a conserved pocket. The domain dimerizes through the hydrophobic &#946;-scaffold in an antiparallel way. Our results point to the &#946;-scaffold as a key element in the light activation, validating a conserved structural basis for light-to-signal propagation in LOV proteins.","palabras_clave":"LOV DOMAIN|HISTIDINE KINASE|BRUCELLA|X-RAY CRYSTALLOGRAPHY|NMR SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89047,"idioma_id":4,"titulo":"The NtrY\/X two-component system of Brucella spp. acts as a redox sensor and regulates the expression of nitrogen respiration enzymes","resumen":"  \t&amp;amp;amp;amp;lt;!--  \t\t@page { margin: 2cm }  \t\tP { margin-bottom: 0.21cm }  \t--&amp;amp;amp;amp;gt;  \t          Brucella  spp.  are facultative intracellular bacteria pathogenic for many mammalian  species including humans, causing a disease called brucellosis.  Learning how Brucella  adapts  to its intracellular niche is crucial for understanding its  pathogenesis mechanism, allowing for the development of new and more  effective vaccines and treatments against brucellosis. Brucella  pathogenesis  resides mostly in its ability to adapt to the harsh environmental  conditions encountered during host infection such as the oxygen  depletion. The mechanism by which Brucella  senses  the oxygen tension and triggers its environmental adaptation is  unknown. In this work we show that the Brucella  abortus NtrY\/NtrX  two-component system is involved in oxygen sensing through a heme  group contained in a Per-ARNT-SIM (PAS) domain of the NtrY histidine  kinase. The NtrY heme iron can be reduced to the ferrous form and is  rapidly oxidized to the ferric form in presence of oxygen.  Importantly, we show that the oxidation state of the heme iron  modulates theautokinase  activity, being the anoxygenic reduced ferrous form the signaling  state of NtrY. Also, we show that ntrY  gene  expression increases under low oxygen tension and that NtrY transfers  its signal to its cognate response regulator NtrX, regulating in this  way the expression of nitrogen respiration enzymes. Based on these  findings, we postulate that NtrY acts as a redox sensor in Brucella  spp.          ","palabras_clave":"BRUCELLA|HEME PROTEIN|HYPOXIA|REDOX SENSOR|TWO-COMPONENT SYSTEM|HOST-PATHOGEN INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89048,"idioma_id":5,"titulo":"Las ciencias agropecuarias como herramienta de crecimiento económico. Un análisis basado en cuatro cultivos extensivos.","resumen":"La producción agropecuaria provee alimentos a la población y genera divisas a los países exportadores. Una de sus fuerzas impulsoras es el desarrollo del conocimiento y la tecnología, herramientas indispensables para permitir el crecimiento sustentable del sector agropecuario. Este trabajo analizó la relación entre la producción de un bien primario y la generación de conocimiento para producirlo en distintos países líderes de productos agrícolas. Mediante un estudio basado en la cantidad de trabajos publicados en revistas científicas encontramos una relación general positiva entre la producción nacional de diversos cultivos y la generación de conocimiento sobre cada uno de ellos. Sin embargo, los países industrializados contribuyeron proporcionalmente más al conocimiento que a la producción física de los cultivos y la mayor parte de su producción científica se publicó en revistas internacionales de mayor impacto científico. Dentro del grupo de países menos industrializados, en general la producción fue proporcionalmente mayor en grano que en conocimiento, excepto para ciertos cultivos en Brasil, China e India. La mayoría del conocimiento producido por este grupo de países se difundió en revistas de menor impacto, con la excepción de Argentina, que mostró un patrón intermedio entre ambos grupos de países. En general, la cantidad de artículos publicados se asoció positivamente a los recursos asignados a la investigación y al desarrollo, que resultó notablemente superior, tanto en términos absolutos como relativos a su Producto Bruto Interno, en los países industrializados. El reconocimiento del papel protagónico de las ciencias para el desarrollo de la agricultura resultará crucial para las economías emergentes y deberá ser un tema central de sus políticas públicas.","palabras_clave":"ANALISIS BIBLIOMETRICO|PRODUCCION CIENTÍFICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89049,"idioma_id":4,"titulo":"Effects of an invasive reef-building polychaete on the biomass and composition of estuarine macroalgal assemblages","resumen":"Invasive species can transform ecological communities. Their profound effects may alter the sources and pathways of primary production. We investigated the effects of the reef forming polychaete Ficopomatus enigmaticus invasion on the biomass and distribution of estuarine macroalgae in a SW Atlantic coastal lagoon (Mar Chiquita, 37 40 S, 57 23 W, Argentina). Reefs built by this species serve as substrates for macroalgal development and furnish structures that modify physical and biological conditions for the surrounding benthos. We showed that (1)he red macroalga Polysiphonia subtilissima settles and grows almost exclusively on the surface of the reef, (2) the green macroalgae Cladophora sp. and Enteromorpha intestinalis are found almost exclusively in areas without reefs attached to mollusk shells and, (3) no macroalgae occur in the sediment between reefs. Manipulative experiments show that reefs provide a complex substrate for settlement and survival and therefore benefit red macroalga. These experiments also show that the invasive reef builder has negative indirect effects on green macroalgae by increasing grazing and probably by increased sedimentation between reefs. Via these direct and indirect effects, reefs change the relative biomass contribution of each macroalgal species to the overall production in the lagoon. Knowledge of these processes is important not only for predicting net effects on primary production but also because changes inmacroalgal species composition may produce effects that cascade through the food web.","palabras_clave":"Coastal lagoon|Macroalgae|Ecosystem engineer|Biological invasion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89050,"idioma_id":4,"titulo":"New records of hypocrealean fungi infecting aphids and whiteflies: pathogenicity against Myzus persicae and interaction with its predator Eriopis connexa","resumen":"Occurrence of hypocrealean entomopathogenic fungi in Argentina is reported. Bioassays were performed to evaluate their pathogenicity against Myzus persicae, and Eriopis connexa. The findings underscore the importance to preserve these fungi and to investigate their potential for vector control. ","palabras_clave":"BIOASSAYS|ENTOMOPATHOGENIC FUNGI|ERIOPIS CONNEXA|HYPOCREALES|MYZUS PERSICAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89051,"idioma_id":4,"titulo":"Relationships between colour parameters, phenolic content and sensory changes of processed blueberry, elderberry and blackcurrant commercial juices","resumen":"There is an increased interest in the consumption of fruits containing high phenolic concentrations such asberry fruits. Attractive colour of berries plays a vital role for consumer acceptance. The aim of this work wasto evaluate colour parameters (a*, b*, L*), phenolic content and sensory changes of blueberry, elderberryand blackcurrant (BC) pasteurised commercial juices during accelerate storage. Initial phenolic concentrationwas 3.21, 10.06, 10.72 g GAE L)1 for blueberry, elderberry and BC, respectively. Moreover, phenolicconcentration of all juices decreased by approximately 40% throughout the first 30 days. Blueberry exhibiteda substantial decrease in a* (40%) in the first 30 days, while elderberry presented a gradual decrease and BConly presented a slight decrease (7%) at the end of storage. Colour preferences decreased when storage timeincreased. However, when consumers were informed that ?the juices are a rich source of phenolics, whichcontribute to reducing risk of suffering chronic diseases?, a high level of purchase intention was obtained.","palabras_clave":"ANTIOXIDANT CAPACITY|BLACKCURRANT|BLUEBERRY|COLOUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89052,"idioma_id":4,"titulo":"Non linear fracture mechanics of polymers: Load Separation and Normalization methods","resumen":"Innovatively here, the Load Separation Principle and the deformation function are expressed in terms of total displacement without distinguishing between elastic and plastic displacement components. Hence, calculations are simply made using the J-Integral formula based on total energy. The performance of the proposed methods is evaluated and compared with the standard multiple-specimen technique for a broad spectrum of ductile polymers. Several features of the approaches are discussed like: suitability of functional forms, influence of blunting assumption, calibration points and general limitations to their application. The results demonstrate the ease and the accurate of the Normalization method based on total displacement for ductile polymer J?R curve determination. Conversely, the great potentiality of Load Separation method relies on the special fracture cases in which the actual final crack length cannot be easily determined.","palabras_clave":"Ductile polymers |fracture toughness testing|J-Integral approach|R curves,"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89053,"idioma_id":4,"titulo":"Depth sensing indentation of organic?inorganic hybrid coatings deposited onto a polymeric substrate","resumen":"PEO-Si\/SiO2 hybrid coatings deposited onto a PVC substrate were micromechanically characterized using depth sensing indentation. The effect of curing time and coating thickness was investigated. Elastic moduli of coated systems determined by the Oliver?Pharr approach displayed a continuous decreasing trend with increasing indentation depth, reflecting that the hybrids are stiffer than the substrate. Aiming to extract coating-only elastic modulus a simple method based on FE simulations was developed. The method was applied to evaluate the  moduli of the hybrid coatings and the values were compared with those obtained by applying different approaches available in literature. The elastic modulus of PEO-Si\/SiO2 hybrids was proven to be practically independent of curing time after 24 h. However, large curing times resulted in coatings being more prone to failure.","palabras_clave":"DEPTH SENSING INDENTATION |ORGANIC-INORGANIC HYBRID COATING|ELASTIC MODULUS|NUMERICAL SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89054,"idioma_id":5,"titulo":"OBSIDIANAS EN LA PAYUNIA (SUR DE MENDOZA, ARGENTINA): PATRONES  DE DISTRIBUCIÓN E IMPLICANCIAS EN LA OCUPACIÓN REGIONAL","resumen":"En este trabajo se presentan los resultados obtenidos del análisis tecnológico de artefactos de obsidiana procedentes del campo volcánico de La Payunia (sur de Mendoza, Argentina). Estudios previos en el centro oeste argentino y Chile central abordaron desde una escala macro regional, el rol las fuentes de obsidiana dentro de las redes de interacción y movilidad humana en diferentes escalas temporales. En La Payunia se identificaron dos fuentes de obsidiana, ubicadas en áreas con características ambientales e historia ocupacional diferentes: fuente El Peceño en área el Nevado y fuente Payún Matrú en área El Payén. Se explora desde escalas meso y micro espaciales, y sobre la base de estudios tecnológicos de artefactos caracterizados por medio de fluorescencia de rayos-X (XRF), las estrategias de abastecimiento y posibles rangos de acción humana en el extremo sur de Mendoza, durante la segunda mitad del Holoceno tardío. Los resultados sugieren marcadas diferencias en el modo uso estas fuentes, así como en la amplitud y direccionalidad de los territorios explotados.","palabras_clave":"Obsidiana|Nord Patagonia|Estrategias de aprovisionamiento|Holoceno tardío|Cazadores-recolectores"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89055,"idioma_id":5,"titulo":"EL REGISTRO ARQUEOBOTÁNICO EN EL VALLE DEL SALADO, MENDOZA: PROBLEMAS TAFONÓMICOS Y EXPLOTACIÓN HUMANA","resumen":"El objetivo del presente estudio es dar a conocer los resultados de la identificación taxonómica de los macrorrestos vegetales  recuperados en las excavaciones arqueológicas llevadas a cabo en el valle del Salado, Malargüe, Mendoza (Argentina), discutiendo  aspectos vinculados al origen de las muestras y al uso de las especies identificadas por parte de las poblaciones humanas.  Los macrorrestos estudiados fueron recuperados durante las excavaciones de los sitios arqueológicos Puesto Jaque II (PJ-II) y  Gendarmería Nacional 5 (GN-5). Temporalmente los sitios corresponderían a los últimos 1000 años a.p. La identificación taxonómica  de los restos arqueobotánicos se basó en el análisis morfológico comparativo de macrorrestos (frutos y semillas) actuales y  arqueológicos. Los resultados sugieren un origen diferencial de las muestras de ambos sitios arqueológicos. Así, mientras que por  un lado la muestra obtenida en PJ-II tendría un origen principalmente antrópico, con el consumo de especies tales como Schinus  polygamus (Cav.) Cabrera, Berberis empetrifolia Lam. y probablemente Oxalis sp. y Chenopodium sp., por el otro, la muestra  proveniente de GN-5 habría tenido un origen natural. En el trabajo se concluye que es poco probable que las dos últimas especies  mencionadas hayan sido consumidas (aunque no se descarta esta posibilidad), siendo su estatus diferente al de las tres especies  previamente mencionadas.","palabras_clave":"ARQUEOBOTÁNICA|AMBIENTES DE ALTURA|SUBSISTENCIA|TAFONOMÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89056,"idioma_id":4,"titulo":"Geographic variation in bone carbonate and water d18O values in Mendoza, Argentina and their relationship to prehistoric economy and settlement","resumen":"Questions of mobility, settlement pattern, and their relation to economic organization and resource use are central to ongoing work in central-western Argentina. Here we analyze geographic patterns in the distribution of 178 human bone carbonate d18O samples, 46 human tooth enamel carbonate d18O samples, and 48 water d18O samples from throughout the Andean Cordillera and Monte Desert and evaluate their implications for prehistoric mobility and economy. We confirm and refine previous generalizations regarding a highland\/lowland dichotomy in water d18O values and show that the range of human carbonate d18O values generally reflect available water sources. While there is little withinlifetime change in patterns of water use, we show that most individuals have stable isotope signatures consistent with water use from multiple areas or areas other than where they were ultimately interred. These data indicate high levels of residential mobility, and we conclude by discussing their implications for our understanding of regional prehistory. ","palabras_clave":"Stable isotopes|d18O|Water|Argentina|Mendoza|Archaeology|Settlement pattern|Mobility|Agriculture"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89057,"idioma_id":5,"titulo":"Modelo ecológico para evaluar la sobreexplotación de Ungulados: implicancias en los conjuntos zooarqueológicos de guanaco del sur de Mendoza","resumen":"Los conceptos ecológicos son útiles para explorar las razones de la declinación en la abundancia de ungulados a través del tiempo. Los datos demográficos, tales como perfiles de mortalidad y datos biométricos que reflejan el tamaño corporal pueden ser analizados conjuntamente para determinar si el decrecimiento en la disponibilidad de presas es el resultado de un incremento de la presión de caza o de un deterioro ambiental. Este último caso está relacionado a la disponibilidad de recursos para las presas. El modelo de depresión de presas de ungulados (UPDM; Ungulate Prey Depression Model) sintetiza conceptos ecológicos y explicita implicancias para la contrastación de hipótesis arqueológicas.Aspectos del modelo y conceptos relacionados han sido usados porlos zooarqueólogos para examinar exitósamente el impacto dela presión de caza y\/o el deterioro ambiental sobre las especies de ungulados. La disminución del guanaco como recurso ha sido propuesta para el registro arqueológico del Holoceno tardío en el sur de Mendoza, como parte de un proceso de intensificación regional. La misma se refleja en la declinación de los Artiodactyla en favor de especies de menor tamaño y la introducción de otros recursos a la dieta, como plantas silvestres y domésticas alrededor de 2000 años AP.Aplicaciones del UPDM podrían ayudar a clarificar el debate actual acerca de las causas que llevaron a la disminución de la importancia relativa del guanaco en la dieta de las poblaciones humanas prehispánicas del sur de Mendoza.","palabras_clave":"GUANACO|DISMINUCIÓN DE RECURSOS|MENDOZA|UNGULADOS|NTENSIFICACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89058,"idioma_id":4,"titulo":"Histopathological changes in the gills and liver of Prochilodus lineatus from the Salado river basin (Santa Fe, Argentina)","resumen":"This study evaluated the histopatholo-gical changes in gills and liver of Prochiloduslineatus inhabiting the Salado River basin. Fish werecollected in four different sampling stations. Thehistological lesions in the tissues were examinedunder light microscopy and evaluated with quantita-tive analyses. The morphometric analysis of the gillsshowed a signi&#64257;cant shortening of secondary lamel-lae and a lower percentage of area for gas exchangein &#64257;sh from station 1 (an urban area, located near themouth of the Salado River) in comparison with &#64257;shgills from the reference site (station 4, a relativelypristine area). Moreover, a signi&#64257;cantly higher areaoccupied with necrotic foci and the occurrence of animportant in&#64258;ammatory response were observed in&#64257;sh liver of station 1 than the samples caught from other stations. Thus, histopathological evidencesshowed differences among sites, which could berelated to different environmental conditions.","palabras_clave":"FISH|HISTOLOGY|BIOMARKER|POLLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89059,"idioma_id":5,"titulo":"yCaracterización microscópica de las glándulas anexas del aparato reproductor masculino de la llama (Lama glama)  y de la alpaca (Lama pacos). Aspectos microscópicos y  macroscopicos","resumen":"Caracterización microscópica de las glándulas anexas del aparato reproductor masculino de la llama (Lama glama)  y de la alpaca (Lama pacos). Aspectos microscópicos y macroscopicos.","palabras_clave":"GLANDULAS |ALPACA |LLAMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89060,"idioma_id":4,"titulo":"An Autonomous Multi-Agent Approach to Supply Chain Event Management","resumen":"Organizations have made significant effort to implement software for planning nd scheduling, but disruptive events management is still a problem to be solved. Because of  disruptive event can affect the overall performance of the supply chain, SCEM (Supply hain Event Management) systems presenting different automation levels such as monitoring, larm, and decision support have been proposed. However, the management of disruptive vents, taking into account the distributed nature of the supply chain, the members´ autonomy, and the ability to exert corrective control actions, has been identified as a problem that requires further research. This work presents an agent-based approach for the SCEM problem, which can perform autonomous corrective control actions to minimize the effect of deviations in the plan that is currently being executed. These control actions consist of a distribution of the variation between supply chain members, using the plan?s slack in a collaborative way. An innovative feature of this approach is its focus on resources, which are affected by disruptive events in a direct way. Based on this approach, a SCEM system is designed as a net of control points defined on resources connected through supply process orders. Two novel aspects are the distributed collaborative inter-organizational architecture of the SCEM system and a Double Contract Net Protocol. This protocol allows a set of resource-representing agents to interact through an agent, representing a supply process order as a mediator. An application to a case study of the Multi-Agent SCEM system implemented with JADE is provided.","palabras_clave":"Multi-Agent|System|Supply|Chain"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89061,"idioma_id":4,"titulo":"Process-Oriented Integration and Coordination of Healthcare Services across Organizational Boundaries","resumen":"To achieve an integration and coordination healthcare services among organizations through inter-organizational processes to enable organizations to provide high quality healthcare integrated services and continuous process improvements, this paper proposes a methodology that follows a top-down approach based on a Model-Driven Architecture. It provides a modeling language that enables organizations conceptualizing an integration agreement, and identifying and designing cross-organizational process models. These models are used for the automatic generation of: process models representing the private view each organization requires to perform the role it fulfills in cross-organizational processes, and Colored Petri Net (CP-Net) specifications to implement these processes. A multi-agent system platform provides agents that interpret CP-Nets and enable the communication between the Healthcare Information Systems of the organizationsfor executing the cross-organizational processes. Clinical documents are defined using the HL7 Clinical Document Architecture. This methodology guarantees that important requirements for healthcare services integration and coordination are fulfilled: interoperability between heterogeneous Healthcare Information Systems; ability to cope with changes in cross-organizational processes; guarantee of alignment between the integrated healthcare service solution defined at the organizational level and the solution defined at technological level; and the distributed execution of cross-organizational processes keeping the organizations autonomy.","palabras_clave":"healthcare|systems|cross-organizational|process"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89062,"idioma_id":4,"titulo":"A Service-Oriented Approach to Collaborative Management of Disruptive  Events in Supply Chains","resumen":"This work presents a comprehensive proposal to systematically address the problem of the Collaborative Management of Disruptive Events in Supply Chains (CMDESC). This is defined as a collaborative business process that specifies a set of decision making activities that require complex models to systematize the activities of capturing information about internal and external changes to predict disruptive events that can affect the schedule execution, and to systematize the activities of feasibility checking and schedule repairing considering the distributed nature of supply chains. A service?oriented approach implementing this collaborative business process is presented. Reference Models developed for automatically derive appropriate executable models for feasibility checking and schedule repairing, and for monitoring orders and resources, are described. Examples of models validation are also described. ","palabras_clave":"bussines|process|SOA|Supply Chain"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89063,"idioma_id":4,"titulo":"Genetic structure in cultivated quinoa (Chenopodium quinoa Willd.) a reflection of landscape structure in Northwest Argentina","resumen":"Quinoa (Chenopodium quinoa Willd.),   one of the main crops domesticated in the Andean highlands 1,000 of   years ago, played an important role as a protein source. 35 germplasm   accessions collected along the Northwest Argentina (NWA) region were   studied using 22 microsatellite (SSR) markers. Results showed a great   level of genetic diversity, differing from previous reports about the   geographical distribution of quinoa variability. All SSR loci analysed   were highly polymorphic detecting a total of 354 alleles among all   populations, with an average of 16 alleles per locus. Cluster analyses   grouped the accessions into four main clusters at the average genetic   distance level (0.80), each of which represented a different environment   of the NWA region: Puna (UHe&nbsp;=&nbsp;0.42, ±0.07 SE), Dry Valleys   (UHe&nbsp;=&nbsp;0.27, ±0.05 SE), Eastern Humid Valleys (UHe&nbsp;=&nbsp;0.16, ±0.04 SE) and   a transition area with high altitudes between the last two environments   (UHe&nbsp;=&nbsp;0.25, ±0.03 SE). An eastward decreasing genetic diversity   gradient was found. AMOVA analyses showed a strong genetic structure: a   high population subdivision relative to the grouping by region   (Fsr&nbsp;=&nbsp;0.47) together with a high genetic differentiation among   populations (Fst&nbsp;=&nbsp;0.58) and a heterozygous defect (Fis&nbsp;=&nbsp;0.63) in each   of them. The variability structure, a reflection of the structure of the   NWA landscapes, is discussed in connection with environmental   variables.","palabras_clave":"GENETIC DIVERSITY|QUINOA GERMPLASM|MICROSATELLITES |NORTHWEST ARGENTINE |CLUSTER ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89064,"idioma_id":4,"titulo":"Cognitive processes in Vespula germanica wasps ( Hymenoptera: Vespidae) when  relocating a food source.","resumen":"The German yellowjacket Vespula germanica (F.) (Hymenoptera: Vespidae), an invasive wasp, is a highly efficient forager. We studied wasp cognitive ability while varying land Mark disposition and cue conspicuity. Learning flights were used as an indicator of forager cognition while relocating a food source.We recorded the number of learning flights (circling above the food location) performed after each visit by each wasp. We studied the effect of modifying a learned location and analyzed how the addition of conspicuous cues affected wasp learning. Cognitive ability also was studied in relation to food manipulation efficiency, i.e., the time taken to extract a piece of meat and fly away. We found that one feeding visit was sufficient for wasps to learn relevant cues asóciate with a rewarded location, as shown by the reduction of learning flights after just one experience. Moreover, wasps reached asymptotic levels in food manipulation after only one feeding visit. The introduction of a contextual change, such as moving the food location a few centimeters from the original feeding site, affected returning foragers, who increased the number of learning flights when leaving the array. Interestingly, enriched contexts with conspicuous cues seemed to facilitate wasp cognition as they performed fewer learning flights than in nonenriched ones. Learning flights seem to be a good cognitive indicator, reflecting wasp experience with a certain context, thus revealing theirsensitivity to landmark cue conspicuity. This study highlights the cognitive capacities of V. germanica foragers.","palabras_clave":"SOCIAL WASP|LEARNING FLIGHT|FORAGING|FOOD MANIPULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89065,"idioma_id":4,"titulo":"Large time-step explicit integration method for solving problems with dominant convection","resumen":"An explicit time integrator without the CFL&nbsp;&lt;&nbsp;1   restriction for the momentum equation is presented. This allows stable   large time-steps in problems dominated by convection, independently of   the spatial discretization.  The idea is to use the information existing at time t=tn   in the velocity streamlines as well as in the acceleration streamlines   to update the particle position as well as the velocity in an updated   Lagrangian frame. The method may be used with moving or fixed meshes.","palabras_clave":"Explicit time integration|Large time-steps|Incompressible fluid flows|Updated Lagrangian formulations|Real Time"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89066,"idioma_id":4,"titulo":"Residence Time Distribution Determination of a Continuous Stirred Tank Reactor using Computational Fluid Dynamics and its Application on the Mathematical Modeling of Styrene Polymerization","resumen":"The continuous operation of a stirred tank reactor for styrene polymerization was modeled. The proposed approach consists of an iterative procedure between two modules that considers the fluid-dynamics and kinetics respectively. The kinetic module considers a complex kinetic mechanism and is used to predict the time evolution of global variables, such as conversion and species concentrations, physicochemical properties and molecular structure characteristics of the final product. In order to obtain a 3D representation of the flow field, the simulation of the hydrodynamics of the reactor was carried out with the aid of a commercial computational fluid dynamics (CFD) software package. Because CFD is capable to predict the complete velocity distribution in a tank, it provided a good alternative to carry out residence time distribution (RTD) studies. It was found that the stimulus-response tracer method is reasonably accurate to obtain a complete RTD compared to the particle tracking method. The obtained RTD results showed a good agreement when validated with experimental data and literature information.From the estimates of the kinetic module and the RTD predictions, a statistical calculus allows the determination of the average properties at the reactor outlet. The convergence of the iterative procedure was tested and reasonable predictions were achieved for an industrial reactor.","palabras_clave":"CFD|residence time distribution|CSTR|polymerization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89067,"idioma_id":4,"titulo":"gdbOF: A Debugging Tool for OpenFOAM","resumen":"OpenFOAM® libraries are a great contribution to CFD community and a powerful way to create solvers and other tools. Nevertheless in this creative process a deep knowledge is needed concerning with classes structure, for value storage in geometric fields and also for matrices resulting from equation systems, becoming a hard task for debugging.    To help in this process a new tool, called gdbOF, attachable to gdb (GNU debugger) is presented in this paper. It allows to analyze classes structure at debugging time. This application is implemented by gdb macros, these macros can access to code classes and also to their data in a transparent way, giving the requested information. This tool is tested for different application cases, such as the assemble and storage of matrices in a scalar advective?diffusive problem, non orthogonal correction methods in purely diffusive tests and multiphase solvers based on Volume of Fluid Method. In these tests several types of data are checked, such as: internal and boundary vector and scalar values from solution fields, fluxes in cell faces, boundary patches and boundary conditions. As additional features of this tool data dumping to file and a graphical monitoring of fields are presented.    All these capabilities give to gdbOF a wide range of use not only in academic tests but also in real problems.","palabras_clave":"Computational fluid dynamics|Finite volume method|OpenFOAM|Data structures|Debugging|gdbOF"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89068,"idioma_id":4,"titulo":"A polyelectrolyte-surfactant complex as support layer for membrane functionalization","resumen":"A polyelectrolyte-surfactant complex, polyallylamine-dodecylsulfate system, is presented as an alternative method for the modification of membranes. Due its chemical structure, the complex, once casted on a surface, is highly stable in aqueous solutions.This allows modifying with the same method different types of membranes, exemplified here by alumina and polycarbonate. Using different strategies, the complex system can   also incorporate other elements useful for catalysis, biorecognition or separation. Two applications are presented: the incorporation of gold nanoparticles to catalyze the reduction of 4-nitrophenol using a polycarbonate membrane, and the modification of alumina with a biotin derivative for the recognition of avidin in label-free sensors.","palabras_clave":"polielectrolito |surfactante|nanopartículas de oro|catalisis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89069,"idioma_id":4,"titulo":"The adsorption of acrolein on a Pt (1 1 1): A study of chemical bonding and electronic structure","resumen":"                The adsorption of acrolein on a Pt  (111) surface was studied using ab-initio and semiempirical calculations.  Geometry optimization and densities of states (DOS) curves were carried out  using the Vienna  Ab-initio Simulation Package (VASP) code. We started our study with the  preferential geometries corresponding to the different acrolein\/Pt (111)  adsorption modes previously reported. Then, we examined the evolution of the  chemical bonding in these geometries, using the crystal orbital overlap  populations (COOP) and overlap population (OP) analysis of selected pairs of atoms.  We analyzed the acrolein intramolecular bonds, Pt (111) superficial bonds and  new molecule-surface formed bonds after adsorption. We found that Pt!  Pt bonds  interacting with the molecule and acrolein C=O and C=C bonds are weakened after  adsorption; this last bond is significantly linked to the surface. The obtained  C! Pt and O!  Pt OP values  suggest that the most stable adsorption modes are &#951;3-cis and &#951;4-trans, while the &#951;1-trans is the less favored configuration. We also  found that C pz orbital and Pt pz and dz2 orbitals participate strongly in the  adsorption process.","palabras_clave":"Bonding|Acrolein|DFT| Pt (111)|Adsorption"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89070,"idioma_id":4,"titulo":"Nd60Fe30Al10 Glass Forming Magnetic Alloys: a Mechanical Spectroscopy Study at the 300- 560 K Temperature Range","resumen":"The ferromagnetic amorphous phase in rapidly solidified Nd60Fe30Al10 glass forming alloys is investigated in melt spun ribbons (100 µm thick) and in chill cast cylinders (2 mm diameter). The amorphous resulting for these two different quenching rates were characterized by their room temperature hysteresis loops, magnetization and differential calorimetric measurements in the temperature range 300K-900K. The mechanical damping was explored in the 300-560 K temperature range, by measuring the internal friction and the shear modulus in a forced inverted pendulum operating in the frequency range 0.1-10Hz. Simultaneously, the electrical resistance of the samples was measured. The internal friction spectra of both, ribbons and a cylinder, exhibit a local maximum at about 500K, arising in a relaxation mechanism. After some thermal cycles the peak parameters stabilize reaching an apparent activation enthalpy of 1.5 eV and a limit relaxation time &#964;0 &#8776; 0.4-2.5 . 10-17s. In both samples, the electrical resistance largely decreases during the first heating run to 560K and remains unchanged during subsequent thermal cycles. No changes in the elastic modulus or in the damping properties are detected at the Curie temperature of the alloys.Full&nbsp;Paper Get the full paper by clicking here The ferromagnetic amorphous phase in rapidly solidified Nd60Fe30Al10 glass forming alloys is investigated in melt spun ribbons (100 µm thick) and in chill cast cylinders (2 mm diameter). The amorphous resulting for these two different quenching rates were characterized by their room temperature hysteresis loops, magnetization and differential calorimetric measurements in the temperature range 300K-900K. The mechanical damping was explored in the 300-560 K temperature range, by measuring the internal friction and the shear modulus in a forced inverted pendulum operating in the frequency range 0.1-10Hz. Simultaneously, the electrical resistance of the samples was measured. The internal friction spectra of both, ribbons and a cylinder, exhibit a local maximum at about 500K, arising in a relaxation mechanism. After some thermal cycles the peak parameters stabilize reaching an apparent activation enthalpy of 1.5 eV and a limit relaxation time &#964;0 &#8776; 0.4-2.5 . 10-17s. In both samples, the electrical resistance largely decreases during the first heating run to 560K and remains unchanged during subsequent thermal cycles. No changes in the elastic modulus or in the damping properties are detected at the Curie temperature of the alloys.","palabras_clave":"Internal Friction| Nd60Fe30Al10| Permanent Magnet"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89071,"idioma_id":4,"titulo":"Stabilized finite element method based on local preconditioning for unsteady compressible flows in deformable domains with emphasis on the low Mach number limit application","resumen":"Flows with low Mach numbers represent a limit situation in the solution of compressible flows. The preconditioning of flow equations is one of the classical approaches proposed to capture the solution in the low Mach number limit. In this method, the time derivatives are premultiplied by a suitable preconditioning matrix in order to achieve a well-conditioned system by means of the scaling of the system eigenvalues. Hence, the modified equations have only steady-state solutions in common with the original system. For the application of these methods to unsteady problems, the dual time-stepping technique has emerged, where the physical time derivative terms are treated as source and\/or reactive terms. The use of a preconditioning matrix defined to compute steady-state solutions may not be a good choice for unsteady problems, as showed by Vigneronit et al. (European Conference on Computational Fluid Dynamics, 2006). However, such matrices can be adapted to perform the computation of transient flows by means of the appropriate redefinition of some coefficients. The application of a \u2018steady-state\u2019 preconditioning matrix to unsteady problems with an ALE (Arbitrary Lagrangian Eulerian) approach is presented. The equations are discretized in space using a stabilized Finite Element method and in time using finite differences. The preconditioning of the governing equations is not applied in the numerical scheme but is used, through the eigenvalues of the preconditioned system, to design appropriately the stabilization term. Several test cases are solved, including incompressible flows and the in-cylinder flow in a motored opposed-piston engine.","palabras_clave":"Low Mach number compressible viscous flows|Local preconditioning|Arbitrary Lagrangian Eulerian|Stabilized finite elements"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89072,"idioma_id":4,"titulo":"K\/CeO2 Catalysts Supported on Cordierite Monoliths: Diesel Soot Combustion Study","resumen":"The combination of filters and oxidation catalysts is one of the most effective aftertreatmenttechniques to eliminate soot particles from the exhaust gases of diesel engines.The activity of powder K\/CeO2 catalysts has been extensively reported in the literature butfew studies refer to K\/CeO2 supported on monoliths. This work presents a study of K\/CeO22 catalysts has been extensively reported in the literature butfew studies refer to K\/CeO2 supported on monoliths. This work presents a study of K\/CeO22 supported on monoliths. This work presents a study of K\/CeO2catalysts supported on cordierite for the reaction of diesel soot combustion. The catalystswere prepared by sequential impregnation of the monolith with ceria and differentpotassium precursors. The activity was studied by temperature-programmed oxidation(TPO) in the soot combustion with loose contact. No deactivation was observed after sixcycles of combustion-soot charge. The activity depends on the potassium precursor used,decreasing in the order KNO3 &gt; K2CO3 &gt; KOH. The structural effects caused by thedifferent precursors of potassium determine the material activity. The X-ray diffractioncharacterization does not indicate a crystalline structure change before and after reaction.The optical microscopy and scanning electron microscope determined a redistribution ofthe crystals in the monolith by heating or by the soot combustion reaction. A weight lossduring the reaction was ascribed to the degradation of the catalytic monolith. The nondeactivationof the samples during the reaction allowed us to discard the volatilization ofthe active species in the temperature range of 20 to 600 ºC, in which the tests wereperformed. On the other hand, the ageing treatments at 800 ºC led to the deactivation ofK\/CeO2 catalysts due to a partial loss of potassium loading.3 &gt; K2CO3 &gt; KOH. The structural effects caused by thedifferent precursors of potassium determine the material activity. The X-ray diffractioncharacterization does not indicate a crystalline structure change before and after reaction.The optical microscopy and scanning electron microscope determined a redistribution ofthe crystals in the monolith by heating or by the soot combustion reaction. A weight lossduring the reaction was ascribed to the degradation of the catalytic monolith. The nondeactivationof the samples during the reaction allowed us to discard the volatilization ofthe active species in the temperature range of 20 to 600 ºC, in which the tests wereperformed. On the other hand, the ageing treatments at 800 ºC led to the deactivation ofK\/CeO2 catalysts due to a partial loss of potassium loading.2 catalysts due to a partial loss of potassium loading.","palabras_clave":"Diesel|Soot|Monolith|Catalysts"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89073,"idioma_id":4,"titulo":"Near-isogenic wheat lines carrying altered function alleles of the Rht-1 genes exhibit differential responses to potassium deprivation","resumen":"Most of the elements involved in the integration of signals of low external K+-supply into a physiological response pathway remain essentially unknown. The aim of this work was to study the in&#64258;uence exerted by DELLA proteins, which are known to be key components for the control of growth, on plant responses during&nbsp; K&nbsp;&nbsp; deprivation&nbsp; in&nbsp; wheat&nbsp; (Triticum&nbsp; aestivum)&nbsp; by&nbsp; using&nbsp; two&nbsp; sets&nbsp; of&nbsp; near-isogenic&nbsp; lines&nbsp; (NILs)&nbsp; in the&nbsp; Maringa&nbsp; and&nbsp; April&nbsp; Bearded&nbsp; cultivars.&nbsp; After&nbsp; K+&nbsp;&nbsp;&nbsp; shortage,&nbsp; the&nbsp; NILs&nbsp; of&nbsp; both&nbsp; cultivars&nbsp; containing&nbsp; the Rht-B1b,Rht-D1b alleles, which encode altered function DELLA proteins, displayed either a slight or no decrease in chlorophyll content, in contrast to the sharp decrease observed in the NILs having the wild type alleles (Rht-B1a,Rht-D1a). That difference was accompanied by a lower relative decrease of biomass accumulation only in the Maringa cultivar. In both cultivars, high chlorophyll retention was coupled with K+&nbsp; starvation-induced differences in superoxide dismutase and ascorbate peroxidase activities, which were enhanced in K+ -starved Rht-B1b,Rht-D1b&nbsp; NILs. In addition, Rht-B1b,Rht-D1b&nbsp; and Rht-B1a,Rht-D1a NILs markedly differed in the accumulation of the major cations Ca2+, Na+ and K+. These results suggest a major role of the Rht-1 genes in the control of physiological responses during K+&nbsp; deprivation. ","palabras_clave":"DELLA|potassium deficiency|Rht|Triticum aestivum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89074,"idioma_id":4,"titulo":"Mitochondrial Fusion Is Essential for Steroid Biosynthesis","resumen":"Although the contribution of mitochondrial dynamics (a balance in fusion\/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve efficient steroid production has never been explored. The mitochondria are central during steroid synthesis and different enzymes are localized between the mitochondria and the endoplasmic reticulum to produce the final steroid hormone, thus suggesting that mitochondrial fusion might be relevant for this process. In the present study, we showed that the hormonal stimulation triggers mitochondrial fusion into tubular-shaped structures and we demonstrated that mitochondrial fusion does not only correlate-with but also is an essential step of steroid production, being both events depend on PKA activity. We also demonstrated that the hormone-stimulated relocalization of ERK1\/2 in the mitochondrion, a critical step during steroidogenesis, depends on mitochondrial fusion. Additionally, we showed that the SHP2 phosphatase, which is required for full steroidogenesis, simultaneously modulates mitochondrial fusion and ERK1\/2 localization in the mitochondrion. Strikingly, we found that mitofusin 2 (Mfn2) expression, a central protein for mitochondrial fusion, is upregulated immediately after hormone stimulation. Moreover, Mfn2 knockdown is sufficient to impair steroid biosynthesis. Together, our findings unveil an essential role for mitochondrial fusion during steroidogenesis. These discoveries highlight the importance of organelles? reorganization in specialized cells, prompting the exploration of the impact that organelle dynamics has on biological processes that include, but are not limited to, steroid synthesis.","palabras_clave":"MITOCHONDRIAL FUSION|STEROIDOGENESIS|ERK1\/2"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89075,"idioma_id":4,"titulo":"Involvement of the L-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth","resumen":"Ethnopharmacological relevance: Prosopis strombulifera (Lam.) Benth. is a rhizomatous shrub that grows in north and central zone of Argentina. In folk medicine, the fruits of this plant have been used as astringent, anti-inflammatory, odontalgic agent and anti-diarrheic. Aim of the study: To investigate the antinociceptive effect of different extracts of P. strombulifera fruits and the involvement of the nitric oxide-L-arginine pathway in this effect.Materials and methods: The antinociceptive effects and the participation of the nitric oxide-L-arginine pathway of different extracts of P. strombulifera fruits were evaluated in vivo using formalin-induced pain test in mice, whereas the inhibitory effect of these extracts on the LPS-induced nitric oxide production and iNOS expression was investigated in vitro using JJ74 macrophage-derived cell lines.Results: The chloroformic extract (CE) caused significant inhibition of both neurogenic and inflammatory phases of formalin test. This antinociception caused by CE in the formalin test was significantly attenuated by the oral treatment with L-arginine. CE also produced a significant and concentration-dependent inhibition of LPS-induced nitric oxide production and iNOS expression in J774A.1 cells.Conclusions: CE of P. strombulifera fruits produced significant antinociception against both neurogenic and inflammatory phases of the mice formalin model, suggesting that the nitric oxide-L-arginine pathway is involved in the analgesic effect. These results seem to indicate that the inhibition of nitric oxide synthesis is involved in the antinociception exerted by CE of P. strombulifera fruits, supporting in part the ethnomedical use of this plant.","palabras_clave":"PROSOPIS STROMBULIFERA|ANTINOCICEPTION|FORMALIN TEST|NITRIC OXIDE|NITRIC OXIDE SYNTHASE|LEGUMINOSAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89076,"idioma_id":4,"titulo":"Discrimination of motile bacteria from filamentous fungi using dynamic speckle","resumen":"We present a dynamic laser speckle method to easily discriminate filamentous fungi from motile bacteriain soft surfaces, such as agar plate. The method allows the detection and discrimination between fungi and bacteriafaster than with conventional techniques. The new procedure could be straightforwardly extended to differentmicro-organisms, as well as applied to biological and biomedical research, infected tissues analysis, and hospitalwater and wastewaters studies.","palabras_clave":"Bacteria|Fungi|Laser |Speckle"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89077,"idioma_id":4,"titulo":"The phosphatidylcholine synthase of Pseudomonas putida A ATCC 12633 is responsible for the synthesis of phosphatidylcholine which acts as a temporary reservoir for Al3+","resumen":"In Pseudomonas putida A ATCC 12633 cells grown with tetradecyltrimethylammonium bromide and exposed to Al3Cl, phosphatidylcholine levels increased, which alleviated stress caused by the Al3+. Here we have cloned and sequenced a gene in this strain that encodes a phosphatidylcholine synthase (PCS) and characterized a pcs-deficient mutant. In the pcs-deficient mutant, detectable levels of phosphatidylcholine were not found, whereas the same mutant was successfully complemented and the enzyme was expressed, indicating that phosphatidylcholine synthesis occurs exclusively via the phosphatidylcholine synthase pathway in this organism. Although under non-stressing growth conditions the pcs-deficient mutant showed a growth likely to wild-type strain, the mutant was much more sensitive when challenged with Al3+, which strongly supports that phosphatidylcholine is involved in the response of P. putida to Al3+ and acts as a temporary reservoir of available ions through the formation of Al3+:PC complexes. ","palabras_clave":"Pseudomonas putida|phosphatidylcholine|phosphatidylcholine synthase |aluminnium"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89078,"idioma_id":5,"titulo":"Iluminación en espacios de trabajo.  Propuestas al protocolo de medición del factor iluminación de la superintendencia de riesgos de trabajo.","resumen":"El presente trabajo analiza el actual marco reglamentario nacional del factor iluminación en espacios de trabajo. A partir de la aprobación por parte de la Superintendencia de Riesgos de Trabajo (SRT) del Protocolo de medición del factor iluminación en puestos de trabajo se analiza su contenido y se realiza una propuesta de inclusión de aspectos representativos del factor iluminación con mayor énfasis en la iluminación natural. Asimismo se incluye un cuestionario para obtener datos de comportamiento y percepción de usuarios. Se espera poder aportar en forma complementaria al protocolo aprobado con las propuestas realizadas. Éstas se completan en el aspecto de modelado y de contrastes para analizar deslumbramientos.","palabras_clave":"ILUMINACIÓN|PUESTOS DE TRABAJO|NORMATIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89079,"idioma_id":5,"titulo":"«Poder legislativo y democracia electoral. Santa Fe, 1912-1930","resumen":"En este trabajo se pone el foco en el ámbito legislativo de un espacio subnacional, la provincia de Santa Fe, en el período de democratización electoral que se abre con la sanción, a nivel nacional, de la ley electoral Sáenz Peña, en 1912, y culmina con el primer golpe de estado en la Argentina. A lo largo de estos años en que la provincia estará gobernada por el partido radical, se analiza: 1. la composición de la legislatura tratando de establecer en qué medida el personal político circula, se renueva o si lo que predomina es la presencia de una elite política que insiste en la permanencia en sus bancas a lo largo del período en estudio; 2. los principales temas de la agenda legislativa; 3. la permeabilidad de la institución legislativa y sus miembros a los conflictos sociales y políticos de esos años.","palabras_clave":"Reforma política|1912|Argentina|Provincia de Santa Fe"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89080,"idioma_id":4,"titulo":"The multi-reference contrast method: facilitating set enrichment analysis","resumen":"Set enrichment analysis (SEA) is used to identify enriched biological categories\/terms within high-throughput differential expression experiments. This is done by evaluating the proportion of differentially expressed genes against a background reference (BR). However, the choice of the \u2018\u2018appropriate\u2019\u2019 BR is a perplexing problem and results will depend on it.  Here, a visualization procedure that integrates results from several BRs and a stability analysis of enriched terms is presented as a tool to aid SEA. The multi-reference contrast method (MRCM) combines results from multiple BRs in a unique picture. The application of the proposed method was illustrated in one proteomic and three microarray experiments. The MRCM facilitates the exploration task involved in ontology analysis on proteomic\/genomic experiments, where consensus terms were found to validate main experimental hypothesis. The use of more than one reference may provide new biological insights. The tool automatically highlights non-consensus terms assisting SEA.","palabras_clave":"Gene Ontology |Genomics, Proteomics |Data integration |Background reference"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89081,"idioma_id":4,"titulo":"Genome of Epinotia aporema granulovirus (EpapGV) a polyorganotropic fast killing betabaculovirus with a novel thymidylate kinase gene","resumen":"Background: Epinotia aporema (Lepidoptera: Tortricidae) is an important pest of legume crops in South America.  Epinotia aporema granulovirus (EpapGV) is a baculovirus that causes a polyorganotropic infection in the host larva.  Its high pathogenicity and host specificity make EpapGV an excellent candidate to be used as a biological control  agent.  Results: The genome of Epinotia aporema granulovirus (EpapGV) was sequenced and analyzed. Its circular  double-stranded DNA genome is 119,082 bp in length and codes for 133 putative genes. It contains the 31  baculovirus core genes and a set of 19 genes that are GV exclusive. Seventeen ORFs were unique to EpapGV in  comparison with other baculoviruses. Of these, 16 found no homologues in GenBank, and one encoded a  thymidylate kinase. Analysis of nucleotide sequence repeats revealed the presence of 16 homologous regions (hrs)  interspersed throughout the genome. Each hr was characterized by the presence of 1 to 3 clustered imperfect  palindromes which are similar to previously described palindromes of tortricid-specific GVs. Also, one of the hrs (hr4)  has flanking sequences suggestive of a putative non-hr ori. Interestingly, two more complex hrs were found in  opposite loci, dividing the circular dsDNA genome in two halves. Gene synteny maps showed the great colinearity  of sequenced GVs, being EpapGV the most dissimilar as it has a 20 kb-long gene block inversion. Phylogenetic  study performed with 31 core genes of 58 baculoviral genomes suggests that EpapGV is the baculovirus isolate  closest to the putative common ancestor of tortricid specific betabaculoviruses.  Conclusions: This study, along with previous characterization of EpapGV infection, is useful for the better  understanding of the pathology caused by this virus and its potential utilization as a bioinsecticide.","palabras_clave":"Baculovirus|Granulovirus|Thymidylate |Epinotia aporema"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89082,"idioma_id":4,"titulo":"Anisotropic response of the moving vortex lattice in superconducting Mo(1-x)Gex amorphous films","resumen":"We have performed magnetic susceptibility measurements in Mo1xGex amorphous thin films biasedwith an electrical current using anisotropic coils. We tested the symmetry of the vortex response changingthe relative orientation between the bias current and the susceptibility coils. We found a region in theDC current\u2013temperature phase diagram where the dynamical vortex structures behave anisotropically. Inthis region the shielding capability of the superconducting currents measured by the susceptibility coilsis less effective along the direction of vortex motion compared to the transverse direction. This anisotropicresponse is found in the same region where the peak effect in the critical current is developed.On rising temperature the isotropic behavior is recovered","palabras_clave":"Superconductivity|2D systems|Transverse critical current|Anisotropic behavior"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89083,"idioma_id":4,"titulo":"Small mammal remains from Cueva Huenul 1, northern Patagonia, Argentina. Taphonomy and paleoenvironments since the Late Pleistocene","resumen":"Small mammal samples from the archaeological sequence of Cueva Huenul 1 (CH1, 36°56´45´´S, 69°47´32'W, Neuquén Province, Argentina) are described and taphonomic and paleoenvironmental conditions assessed. This site is located near the steppe-monte ecotone in the northernmost Patagonia. Small mammal remains (NISP = 1426, MNE= 1409, MNI = 87) were recovered from Late Pleistocene (13,800-11,800 14C years BP), Early Holocene (9500 14C years BP) and Late Holocene layers (1400 14C years BP). Taphonomic analysis indicates that the CH1 assemblage is an archaeofaunistic owl pellet accumulation. It has a good post-depositional preservation since it was rapidly incorporated in the sedimentary matrix, although it previously experienced trampling action. From latest Pleistocene to Late Holocene the assemblages are mainly composed by the sigmodontines Eligmodontia spp. and Phyllotis xanthopygus, and the caviomorphs Microcavia australis and Ctenomys sp., suggesting in overall terms a marked ecological stability. CHl is one of the few sites where the Pleistocene-Holocene transition is represented by faunal evidence. The latest Pleistocene sample spanning 13,800 and 11,800 14C years BP indicate scrub steppe with substantial open ground and rocky exposition; one Early Holocene sample (9500 14C years BP) suggests a more heterogeneous environment as evidenced by the first occurrence of Akodon iniscatus and Euneomys chinchilloides. In this context, CH1 assemblages do not reflect the small mammal community reworking that putatively accompanied the Pleistocene-Holocene transition.","palabras_clave":"PALEOECOLOGIA|ARQUEOLOGIA|ROEDORES|TAFONOMÍA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89084,"idioma_id":4,"titulo":"Checklist of the Argentine Agaricales I. Amanitaceae, Pluteaceae and Hygrophoraceae","resumen":"A checklist of species belonging to families Amanitaceae, Plutaceae, and Hygrophoraceae was made for Argentina. The list included all species published till year 2011. Eleven genera and 150 species were recorded. The family Pluteaceae is the most cited for the country with 93species.","palabras_clave":"AMANITA|PLUTEUS|HYGROCYBE|AGARICOMYCETES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89085,"idioma_id":4,"titulo":"New species and records of Pouzarella (Agaricomyetes, Entolomataceae) from northern Argentina","resumen":"Five new species of Pouzarella are described from northern Argentina, P. brunneonigrescens, P. olivacea, P. parvispora, P. sulcata and P. variabilis. Pouzarella ferreri var. ferreri is also reported for the first time from Argentina. All known Pouzarella species reported from Argentina are discussed and a key to species is provided.","palabras_clave":"Biodiversity|mushrooms|Yungas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89086,"idioma_id":4,"titulo":"Improvements in the Design of the Ammonia Synthesis Process implementing Counter Current Gas Permeation Modules","resumen":"This paper explores mass exchanging the outlet and inlet streams of the reactor, following a design heuristic proposed by Fischer and Iribarren in Industrial and Engineering Chemistry Research 2011, 50 (11), 6849&#8722;6859 within the Hierarchical Process Design Procedure by J. M. Douglas in Conceptual Design of Chemical Processes, McGraw-Hill, 1988. When applied to the ammonia synthesis process, this design methodology generated a process alternative different from that previously proposed by other authors, resorting to ceramic membrane counter current gas permeation units to perform the mass exchange of hydrogen. This alternative design is shown to produce a reduction of the gas recycle stream (hydrogen and nitrogen) of up to an interesting 8.40%, reducing recompression associated costs. However, as the present cost of zeolite membranes is still high and their hydrogen-nitrogen selectivity moderate, in the optimal economical solution, the net annual income amounted to 4.56%, corresponding to U.S. $817,793\/year savings. The heuristic was used again at a later refinement stage, yielding an appreciable percent reduction in the cost of recovering hydrogen from the purge. As gas permeation technology (and hydrogen permeation, in particular) is a very active R&amp;D area, we hope that the results of this paper bring some attention to this novel (concentration driven) counter current application for gas permeation modules, apart from the presently more widespread (pressure driven) cross-flow application.","palabras_clave":"PROCESS|DESIGN|MEMBRANES|AMMONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89087,"idioma_id":4,"titulo":"Staufen: from embryo polarity to cellular stress and neurodegeneration","resumen":"Staufen is a double-stranded RNA-binding protein that forms RNA granules by RNA-dependent and -independent interactions. Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate mRNA transport, thus affecting neuron plasticity, learning and memory. Staufen also regulates translation and mRNA decay. In recent years, Staufen was shown to be an important regulatory component of stress granules (SGs), which are large aggregates of silenced mRNPs specifically induced upon acute cellular stress. SGs contribute to cell survival by reprogramming translation and inhibiting pro-apoptotic pathways, and Staufen appears to negatively modulate SG formation by several mechanisms. More recently, mammalian Staufen was found in RNA granules and pathological cytoplasmic aggregates related to SGs containing huntingtin, TDP43, FUS\/TLS or FMRP. In addition, Staufen binds CUG repeats present in mutant RNAs causative of degenerative conditions, thus ameliorating disease. Finally, Staufen affects HIV and influenza infection at several levels. Collectively, these observations unveil important roles for Staufen-mediated posttranscriptional regulation in a growing number of human diseases.Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate mRNA transport, thus affecting neuron plasticity, learning and memory. Staufen also regulates translation and mRNA decay. In recent years, Staufen was shown to be an important regulatory component of stress granules (SGs), which are large aggregates of silenced mRNPs specifically induced upon acute cellular stress. SGs contribute to cell survival by reprogramming translation and inhibiting pro-apoptotic pathways, and Staufen appears to negatively modulate SG formation by several mechanisms. More recently, mammalian Staufen was found in RNA granules and pathological cytoplasmic aggregates related to SGs containing huntingtin, TDP43, FUS\/TLS or FMRP. In addition, Staufen binds CUG repeats present in mutant RNAs causative of degenerative conditions, thus ameliorating disease. Finally, Staufen affects HIV and influenza infection at several levels. Collectively, these observations unveil important roles for Staufen-mediated posttranscriptional regulation in a growing number of human diseases.","palabras_clave":"STAUFEN|RNA BINDING PROTEIN|MRNA TRANSPORT|STRESS GRANULES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89088,"idioma_id":4,"titulo":"Managing Distribution in Refined Products Pipelines Using Discrete-Event Simulation","resumen":"The management of oil products pipelines represents a critical task in the daily operation of petroleum supply chains. Efficient computational tools are needed to schedule pipeline operations in a reliable and cost-effective manner. This work presents a novel discrete event simulation system for the detailed scheduling of a multi-product pipeline consisting of a sequence of pipes that connects a single input station to several receiving terminals. The pipeline is modeled as a non-traditional multi-queuing system involving a number of servers at every pipe end that perform their tasks in a synchronized manner. By using alternative priority rules, the model decides which server should dispatch the entity waiting for service to the associated depot. Also, the model deals with the timely fulfillment of terminal demands and the system response to unexpected events. In combination with optimization tools, the proposed simulation technique permits to easily manage real-world pipelines operations with low computational effort.","palabras_clave":"Delivery Schedule|Discrete-Event Simulation|Multi-Server Queuing System|Petroleum Supply Chain"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89089,"idioma_id":4,"titulo":"Rigorous scheduling of mesh-structure refined petroleum pipeline networks","resumen":"Pipeline networks represent the major mode of transportation for crude oil and refined fuels. Recent data suggest that this trend will persist in coming years. A multiproduct pipeline network can be described as a set of interconnected pipelines with several input and receiving terminals. In the most general case, it has a mesh-like configuration with alternative paths between two terminals. Pumping and delivery operations should be scheduled all at once in an integrated fashion. This work introduces a novel MILP continuous-time formulation for the scheduling of mesh pipeline networks. The pipeline operational plan is conceived as a sequence of composite pumping runs each one involving at most a batch injection at every input station. The model solution simultaneously provides the timing of batch inputs at every source, the product sequence and lot sizes at every pipeline, and the flows diverted to terminals. Three examples of growing complexity were successfully solved at low CPU times. ","palabras_clave":"MULTIPRODUCT PIPELINE NETWORK|MESH STRUCTURE|OPERATIONAL PLANNING|CONTINUOUS APPROACH|MILP FORMULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89090,"idioma_id":4,"titulo":"Detailed Scheduling of Single-Source Pipelines with Simultaneous Deliveries to Multiple Offtake Stations","resumen":"Continuous formulations for the scheduling of single-source pipelines with multiple distribution terminals have already been published. They help the scheduler make key operating decisions such as the sequence of batch injections at the input station, the batch sizes, the start and end times of pumping runs, and the set of aggregate product deliveries to perform during each run. In this way, the aggregate pipeline schedule is defined. However, the scheduler has yet to decide not only on the order of execution of such product extractions but also the number of batch cuts to make to accomplish each aggregate delivery. Therefore, it becomes necessary to refine the aggregate schedule. Most previous contributions providing a refined delivery plan have assumed that product withdrawals at receiving locations over a single-source pipeline should be made one at a time. However, such pipelines do not actually work in this way because their operators usually perform simultaneous product deliveries to cut down on pump operating and maintenance costs. By doing so, they seek to reduce the number of pipeline segments where the liquid flow should be restarted. This article presents a new mixed-integer linear programming (MILP) continuous formulation for developing the detailed schedules of single-source pipelines assuming that simultaneous deliveries to multiple receiving terminals can be performed. The problem goal is to minimize the overall flow restart and stoppage volumes through the smallest number of pipeline operations. Solutions to two examples obtained with the proposed approach present significant reductions in both the operating cost and the CPU time with respect to previous contributions.","palabras_clave":"MULTIPRODUCT PIPELINE SYSTEM|DETAILED SCHEDULING|MILP MATHEMATICAL APPROACH|SIMULTANEOUS PRODUCT DELIVERIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89091,"idioma_id":4,"titulo":"Characterization of the lightning activity of 'Relámpago del Catatumbo'","resumen":"The 'Relámpago del Catatumbo' (Catatumbo Lightning) is a phenomenon known for more than 500 years that occurs in Venezuela. This phenomenon occurs almost all along the year in a very small region of the southwest region of Maracaibo Lake and, according to the Lightning Imaging Sensor (LIS) data, this region presents the highest lightning activity of the world. The region presents a complex topography with particular climate conditions. The lightning activity of the region was examined using the World Wide Lightning Location Network (WWLLN) data. The results show two very localized high-lightning activity centers, one of them is confined around [9.5° N; 71.5° W] over the southwest region of the Maracaibo Lake, and the another one is around [9°N; 73°W] near the Colombia-Venezuela border. The lightning activity has a semiannual behavior with two maxima, one around May and another one around October. The diurnal cycle shows substantial lightning activity during local night.","palabras_clave":"CATATUMBO LIGHTNING|WORLD WIDE LIGHTNING LOCATION NETWORK|LIGHTNING IMAGING SENSOR|HIGHEST FLASH RATE OF THE GLOBE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89092,"idioma_id":4,"titulo":"Management System for Product Development Process for Small And Medium Enterprises which Produces Drugs","resumen":"Management of the Product Development Process (PDP) involves performing a set of activities, in which should intervene the majority of functional areas of the organization. Each of them is carried out taking into account the product to develop, business strategy and the philosophical conception of the company.The PDP management is performed by reference models involving tools, concepts and practices. Its structure is advantageous for all companies, as it improves the understanding of customer needs in the early stages of development, reduces duplication of work in the stages of development and helps control the cost, quality and schedule project. However, this task is not easy for Small and Medium Enterprises (SMEs), mainly due to: (i) lack of knowledge about the product engineering practices, (ii) the lack of skilled and knowledge and \/ or appropriate management techniques for planning, monitoring and control of projects, (iii) organizational difficulties of each company that operates in unstable environments, with social and cultural difficulties and (iv) other external features that harm the internal performance of the companies.In this paper a System for Management of the Product Development Process for Small and Medium Enterprises Producing Drugs is developed, taking into account the reference model of Rozenfeld [1] and the characteristic parameters of the companies. The proposed management system is developed in order to improve procedures in the development of products, taking into account the culture of business, so as to adjust, adapt and be accepted by the community productive. Furthermore, the system is developed in terms of competitive environment, strategies and capabilities of enterprises, presenting concepts, tools and information flow applied in the various activities for understanding and translating customer requirements, improving product specifications of its production process and monitoring.","palabras_clave":"Management|Drugs Development|SMEs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89093,"idioma_id":5,"titulo":"ESTUDIO DEL COMPORTAMIENTO DE MUROS DE GRAN ESPESOR SOLICITADOS BIAXIALMENTE","resumen":"Las técnicas constructivas de comienzos del siglo XX en la ciudad de Mendoza se caracterizan por edificaciones con muros de mampostería de ladrillos cerámicos macizos asentados con mortero de cal. Es común encontrar diferentes tipos de aparejo en una misma estructura, pero en general todos conformando muros de grandes espesores que varían entre 30 cm y 75 cm o más. Un desafío actual consiste en el análisis de estructuras de estas características que han sido afectadas por acciones sísmicas y el paso del tiempo, para ser rehabilitadas. El empleo de materiales para refuerzo se fundamenta en muchos casos en resultados de ensayos obtenidos en muros de menor espesor. En el presente trabajo se estudia el comportamiento de muros de mampostería simple de espesores mayores a los convencionales sometidos a cargas estáticas equivalentes a la fuerza sísmica. También se analiza el comportamiento de estos muros con una propuesta de refuerzo. Se presentan resultados de ensayos obtenidos a través de la simulación numérica efectuada mediante el uso del software Abaqus, con el objeto de analizar el comportamiento de este tipo de muros. En un próximo trabajo se contrastarán estos resultados con los obtenidos en ensayos experimentales a realizar sobre las probetas ya materializadas, así como se estudiará la influencia del refuerzo.","palabras_clave":"mampostería|gran espesor|simulación |biaxial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89094,"idioma_id":4,"titulo":"Sources and distribution of aliphatic and polyaromatic hydrocarbons in coastal sediments from the Ushuaia Bay (Tierra del Fuego, Patagonia, Argentina)","resumen":"Abstract. The environmental quality of Ushuaia Bay, located at the southernmost tip of South America, is affected by the anthropogenic pressure of Ushuaia city. In this study, levels and sources of hydrocarbons in coastal sediments were assessed. Aliphatic hydrocarbon fractions ranged between 5.5 and 1185.3 mg\/g dry weight and PAHs from not detected to 360 ng\/g. Aliphatic diagnostic indices, the nalkanes homologous series occurrence, Aliphatic Unresolved Complex Mixtures (AliUCMs), and pristane and phytane isoprenoids indicated a petrogenic input. Some sites showed biogenic features masked by the anthropogenic signature. Particularly in port areas biodegradation processes were evident. PAH ratios showed a mixture of petrogenic and pyrogenic sources. Aliphatic and aromatic UCMs were strongly correlated, reflecting chronic pollution. Three areas were distinguished inside the bay: (1) east, with low hydrocarbons impact; (2) central, where hydrocarbons accumulation was related to source proximity and sediment characteristics; (3) south-west, where sediment characteristics and current circulation favour hydrocarbons accumulation.","palabras_clave":"Hydrocarbon sources  |PAH ratios |Aliphatic diagnostic indices|Ushuaia Bay |Beagle Channel"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89095,"idioma_id":4,"titulo":"Nitrate reduction activity determined with a continuous flow-through system in sediments from a subantarctic coastal environment","resumen":"Sedimentation and accumulation of autochthonous and allochthonous organic detritus in marinesediments stimulate microbial activity, consume dissolved oxygen and decrease redox potential. Inanaerobic conditions, other electron acceptors are utilized in organic matter oxidation process. Nitrate reduction is an important pathway which is related with nitrogen cycling and oxidation. The purpose of this study was to assess the nitrate reduction activity in sediments of Encerrada Bay, which is under a strong anthropogenic influence from Ushuaia city. Sediment samples were taken in September 2007 with a Van-Veen dredge and stored in darkness. Nitrate reduction activity was estimated in vitro using continuous flow-through system. Nitrate uptake rate followed a Michaelis-Menten kinetic where Km and Vmax values were equal to 1028 &#956;M and 2.7 &#956;mol g-1 h-1, respectively. We concluded that nitrate is used principally as terminal electron acceptor during the oxidation of organic compounds in sediment of Encerrada Bay.","palabras_clave":"nitrato|amonio|reactor|denitrificación|Patagonia argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89096,"idioma_id":4,"titulo":"Near-threshold properties of the electronic density of layered quantum dots","resumen":"We present a way to manipulate an electron trapped in a layered quantum dot based on near-threshold properties of one-body potentials. First, we show that potentials with a simple global parameter allow the manipulation of the wave function, changing its spatial localization. This phenomenon seems to be fairly general and could be implemented using current quantum-dot quantum-well technologies and materials if a proper layered quantum dot is designed. So, we propose a model layered quantum dot that consists of a spherical core surrounded by successive layers of different materials. The number of layers and the constituent materials are chosen to highlight the near-threshold properties. The manipulation of the spatial localization of the electron in a layered quantum dot yields results consistent with actual experimental parameters.","palabras_clave":"Quantum Dot|Electronic Density|Near Threshold|Optical Properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89097,"idioma_id":5,"titulo":"Production and evaluation of a purified protein derivative from an Argentine strain of Mycobacterium avium subsp. paratuberculosis","resumen":"Los derivados proteicos purificados (PPD) son mezclas antigénicas no definidas obtenidas de distintas  micobacterias. Los PPD bovino (PPDb) y PPD aviar (PPDa) son los antígenos que se emplean para evaluar la  respuesta inmunitaria celular en infecciones como tuberculosis y paratuberculosis en el bovino. El PPDa comercial  se produce a partir de Mycobacterium avium subsp. avium, y no a partir de la subespecie paratuberculosis. En  este trabajo se seleccionó una cepa local de Mycobacterium avium subsp. paratuberculosis cuyo patrón molecular  por RFLP es el más frecuente entre los aislamientos de nuestro país que han sido estudiados, y a partir de esta,  se obtuvo un derivado proteico purificado: PPDj-IB. Se emplearon tanto el PPDa comercial como el PPDj-IB como  antígenos en la prueba de liberación de gamma-interferón en animales de un tambo con paratuberculosis y en  animales control. Aun cuando ambos PPD fueron capaces de estimular diferencialmente la liberación de la  citoquina en el tambo infectado (respecto de los tambos control), no hubo diferencias significativas en los niveles  de estimulación producidos y solo dos animales fueron positivos mediante el empleo de PPDj-IB. A partir del  análisis por Western blot se demostró que el contenido de lipoarabinomano y del antígeno Apa\/ModD era distinto  en los PDD evaluados. Estas diferencias podrían explicar, en parte, las diferencias en los niveles de estimulación  en términos individuales. Si bien el empleo de PPDj-IB no mejoró significativamente los resultados de la prueba de  liberación de &#947;IFN, es importante destacar que se logró producir en el laboratorio un PPD apto para su empleo en  ensayos in vitro","palabras_clave":"diagnóstico|paratuberculosis|antígenos |gamma interferón"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89098,"idioma_id":4,"titulo":"Accuracy assessment and screening of a dairy herd with paratuberculosis by three different ELISAs","resumen":"Although the culture of Mycobacterium avium subsp. paratuberculosisis is the gold standardfor the diagnosis of paratuberculosis, this bacterium is difficult to grow. In contrast,serological tests like ELISAs are inexpensive, rapid, and easy to perform. The aims of thisstudy were to evaluate the accuracy of three different ELISAs: one with the commercialantigen PPA-3, another one with L5P (a recently described lipopentapeptide), and a thirdone with an in-house antigen whole cell lysates (WCL) of M. avium (MAA) strain D4ER(Study 1), and to compare them with other tests for paratuberculosis (PTB) diagnosis(Study 2). In Study 1, the sensitivities of the three ELISAs tested were 74.1%, 37% and 74.1%,respectively, whereas their specificities were 98.9%, 100% and 100%, respectively. In Study2, we compared the three above-mentioned ELISAs with the intradermal reaction testusing Avian PPD (PPDa) and fecal culture associated with Ziehl\u2013Neelsen stain and PCRtests, in a dairy herd with 4.6% of cows with clinical signs of PTB. The results showed thatfecal samples from 14 cows (16%) were culture-positive and that fecal samples from ninecows (10%) were PPDa-positive. Most of these animals (culture-positive and PPDapositive)were detected as positive with any of the three ELISAs tested. Serological resultsshowed that 31% of the animals were positive to ELISA-PPA-3, 17% to ELISA-L5P and 42.5%to ELISA-WCL. The combination of these three ELISAs identified 50.6% of the animals aspositive in the infected herd. In particular, the results show that the locally developedELISA seems to be useful for identifying many infected animals in a herd.","palabras_clave":"Diagnosis|Paratuberculosis|ELISA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89099,"idioma_id":4,"titulo":"Trace metal concentrations in Southern Right Whale (Eubalaena australis) at Península Valdés, Argentina","resumen":"The presence of essential (Fe, Mn, Zn, Cu, Ni and Al) and non-essential trace metals (Cd and Pb) was tested in liver (N&nbsp;=&nbsp;26) and kidney (N&nbsp;=&nbsp;42) from dead Southern Right Whale (SRW ? Eubalaena australis)   calves found beached in Península Valdés, Argentina. Essential metals   were detected in all samples, particularly in hepatic tissue; though Ni   and Al were accumulated mainly in the kidney. Cd and Pb were not   detected in any samples. Sex and length of calves did not influence   metal levels found, nor did the geographic location of carcasses. Our   findings for essential metals were similar to those reported for   mysticetes in other parts of the world. Except for a previous report on   one SRW calf, this is the first data on trace metals for this species in   Patagonia. This information is vital for SRW management considering   increasing human pressures impacting their feeding and breeding grounds.","palabras_clave":"Southern Right Whale |Trace metals |Península Valdés |Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89100,"idioma_id":4,"titulo":"Aggressiveness variation of Fusarium graminearum isolates from Argentina following point inoculation of field grown wheat spikes","resumen":"Aggressiveness variation among isolates of Fusarium graminearum from Argentina was analyzed by following disease development on point inoculated spikes of field grown wheat. Two aspects of the capacity of the isolates to induce disease were observed: (i) the infection efficiency reflected by the ability to produce symptoms and evaluated as the number of symptomatic spikes over the inoculated ones; and (ii) the size of the lesion provoked, which is reflected by the number of symptomatic spikelets over its total number. One hundred and twelve isolates were found to induce significantly different levels of disease severity, reflecting variation in aggressiveness. Differences were also found between the isolates for the thousand kernel weight (TKW) and the area under the disease progress curve (AUDPC) and the correlations between disease severity, AUDPC, and TKW were highly significant. Based on disease severity, isolates were clustered as low, medium and highly aggressive and both lesion size and infection efficiency were significantly different between these groups. The movement of the pathogen in the spike occurred primarily downwards the point of inoculation. Movement towards the upper portion was related with the aggressiveness of the isolates and the premature ripening of the spike appeared to be a function of isolate aggressiveness. In this work point inoculation allowed us to study not only the aggressiveness of a large collection of F. graminearum isolates but also to analyze the development of FHB symptoms in large numbers of spikes under conditions similar to those in which this disease naturally occurs. ","palabras_clave":"INFECTION EFFICIENCY|DISEASE SEVERITY|FUSARIUM HEAD BLIGHT|TRITICUM AESTIVUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89101,"idioma_id":4,"titulo":"Delta Np63 is regulated by BMP4 signaling and is required for early epidermal development in Xenopus","resumen":"It has been established in several models that the p63 gene has an important role in the development of the epidermis and its derivatives. In&nbsp; Xenopus, only the&nbsp; &#8710;Np63 isoform of this gene has been cloned and its role during epidermal development remains unknown. In this work we showed that &#8710;Np63 is expressed in the non2neural ectoderm since the gastrula stage and that it is regulated by the BMP4 signaling pathway. Our&nbsp;in vivo and in vitro experiments demonstrated that &#8710;Np63 is required in the earliest inductive steps of epidermal development. The overexpression&nbsp; of&nbsp; &#8710;Np63 caused an increase in epidermal markers with a suppression of neural induction while the blocking of &#8710;Np63 led to the opposite results. Finally, we found that&nbsp; &#8710;Np63 acts as an antiapoptotic gene, regulating the transcription of some apoptotic and anti2apoptotic factors. Taken together, these results suggest that&nbsp; &#8710;Np63&nbsp; is an essential gene in early epidermal specification under the control of BMP4.                                                                                                                                     ","palabras_clave":"EPIDERMIS|SPECIFICATION|BMP4|deltaNp63"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89102,"idioma_id":4,"titulo":"Expansion  and  intensification  of  row  crop  agriculture  in  the  Pampas  and  Espinal of  Argentina  can  reduce  ecosystem  service  provision  by  changing  avian  density","resumen":"In Argentina, the rapid expansion and intensification of row crop production that has occurred during the last 20 years has resulted in the loss of habitat and spatial heterogeneity in agroecosystems. One of the principal effects of industrialized row crop production is the loss of avian diversity and associated ecosystem services that benefit crop production. To better understand the response of bird species to the intensification and expansion of row crop agriculture in Argentina, and the potential effects on the provision of ecosystems services, we analyzed the relationship between short- and long-term changes in agricultural land use on the densities of six bird species (Milvago chimango, Caracara plancus, Tyrannus savana, Zenaida auriculata, Molothrus bonariensis, and Sturnella supercilliaris) using data from a large-scale, long-term avian monitoring program in central Argentina. Species densities responded individually to long-term landuse changes; T. savana and M. chimango densities were positively related to an increase in the annual cropping area, whereas C. plancus and S. supercilliaris were positively related to the area of non-plowed fields. M. bonariensis and Z. auriculata (considered crop pests) showed a weak relationship with land use. None of the species exhibited response to short-term changes in land-use. Although generalist species can apparently adapt to a diversity of open habitats, species that provide pest control services were also related to semi-natural habitats and thus likely to suffer from land transformation associated with intensive agricultural management. Our results, as well as those found in similar systems, denote strong inferential evidence that the disappearance of remnants of natural and semi-natural habitats in heavily transformed agricultural landscapes will have a substantial negative effect on the provision of pest control services provided by avian abundance and diversity.","palabras_clave":"ARGENTINA|BIRD DENSITY|REGIONAL BIRD SURVEY |ECOSYTEM SERVICES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89103,"idioma_id":4,"titulo":"Detection and characterization of a new metallocarboxypeptidase inhibitor from Solanum tuberosum cv. Desirèe using proteomic techniques","resumen":"Protease inhibitors have been considered only as long as anti-nutritional factors, but have regained much interest in recent years because of their potential anti-cancer action and also because of its positive dietary effects. A new potato carboxypeptidase inhibitor (PCI) was isolated using proteomics techniques; the inhibitor was detected in an extract of Solanum tuberosum cv. Desirée by intensity fading MALDI-TOF mass spectrometry, and then was purified and characterised. The mass spectral from tryptic digestion (peptide mass fingerprint) was analysed with the \u201CMASCOT search tool\u201D and did not match any of the inhibitors of other plants. Protein identification and differentiation by peptide mass fingerprinting (PMF) has been adopted in our group as an excellent tool to differentiate, in fast an unequivocal way, proteins with very similar physicochemical and functional properties. The new PCI exhibited a molecular mass of 4218 Da and consists of a single polypeptide chain with an isoelectric point of 6.5. MALDI-TOF\/TOF sequence analysis allowed determines a sequence belonging to the inhibitor.","palabras_clave":"Carboxypeptidase inhibitor|Plant inhibitor|Solanum tuberosum|Protease"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89104,"idioma_id":4,"titulo":"Cyclooxygenase-2 Prostaglandins Mediate Anandamide-Inhibitory Action on Nitric Oxide Synthase Activity in the Receptive Rat Uterus","resumen":"Anandamide, an endocannabinoid, prostaglandins derived from   cyclooxygenase-2 and nitric oxide synthesized by nitric oxide synthase   (NOS), are relevant mediators of embryo implantation. We adopted a   pharmacological approach to investigate if anandamide modulated NOS   activity in the receptive rat uterus and if prostaglandins mediated this   effect. As we were interested in studying the changes that occur at the   maternal side of the fetal?maternal interface, we worked with uteri   obtained from pseudopregnant rats. Females were sacrificed on day 5 of   pseudopregnancy, the day in which implantation would occur, and the   uterus was obtained. Anandamide (2&nbsp;ng\/kg, i.p.) inhibited NOS activity   (P&nbsp;&lt;&nbsp;0.001) and increased the levels of prostaglandin E2 (P&nbsp;&lt;&nbsp;0.001) and prostaglandin F2&#945;   (P&nbsp;&lt;&nbsp;0.01). These effects were mediated via cannabinoid receptor   type 2, as the pre-treatment with SR144528 (10&nbsp;mg\/kg, i.p.), a selective   cannabinoid receptor type 2 antagonist, completely reverted anandamide   effect on NOS activity and prostaglandin levels. The pre-treatment with a   non-selective cyclooxygenase inhibitor (indomethacin 2.5&nbsp;mg\/kg, i.p.)   or with selective cyclooxygenase-2 inhibitors (meloxicam 4&nbsp;mg\/kg,   celecoxib 3&nbsp;mg\/kg, i.p.) reverted anandamide inhibition on NOS,   suggesting that prostaglandins are derived from cyclooxygenase-2   mediated anandamide effect. Thus, anandamide levels seemed to modulate   NOS activity, fundamental for implantation, via cannabinoid receptor   type 2 receptors, in the receptive uterus. This modulation depends on   the production of cyclooxygenase-2 derivatives. These data establish   cannabinoid receptors and cyclooxygenase enzymes as an interesting   target for the treatment of implantation deficiencies.","palabras_clave":"IMPLANTATION|ENDOCANNABINOIDS|NITRIC OXIDE|UTERUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89105,"idioma_id":4,"titulo":"The Plastic and Liquid Phases of CCl3Br Studied by Molecular Dynamics Simulations","resumen":"We present a molecular dynamics study of the liquid and plastic crystalline phases of CCl3Br. We investigated the short-range orientational order using a recently developed classification method and we found that both phases behave in a very similar way. The only differences occur at very short molecular separations, which are shown to be very rare. The rotational dynamics was explored using time correlation functions of the molecular bonds. We found that the relaxation dynamics corresponds to an isotropic diffusive mode for the liquid phase but departs from this behavior as the temperature is decreased and the system transitions into the plastic phase","palabras_clave":"Dinámica Molecular|Cristales plásticos|relajación|correlaciones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89106,"idioma_id":4,"titulo":"Identification and validation of Trypanosoma cruzi's glycosomal adenylate kinase containing a peroxisomal targeting signal","resumen":"Adenylate kinases are key enzymes involved in cell energy management. Trypanosomatid organisms have the largest number of isoforms found in a single cell, constituting a major difference with the mammalian hosts. In this work we study an adenylate kinase, TcADK3, the only Trypanosoma cruzi protein harboring the putative peroxisomal (glycosomal) targeting signal, '-CKL'. Parasites expressing GFP fused to TcADK3 showed a strong fluorescence in the glycosomes. The same result was obtained when the tripeptide '-CKL' was added at the C-terminus of the GFP, demonstrating that this signal is necessary and sufficient for targeting proteins to glycosomes. When this tripeptide was removed from the GFP-TcADK3 fusion protein, the fluorescence was re-localized in the cytoplasm. The CKL signal could be used for targeting foreign proteins to the glycosomes. This model also provides a useful tool to study glycosomes dynamics, morphology or number in living parasites in any stage of the life cycle.Copyright © 2012 Elsevier Inc. All rights reserved.","palabras_clave":"Trypanosoma cruzi|Adenylate kinase|Glycosome|Peroxisomal targeting signal"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89107,"idioma_id":5,"titulo":"LA VÍA DE TRANSDUCCIÓN DE SEÑALES TOR DE MAMÍFEROS ESTÁ PRESENTE EN TRYPANOSOMA CRUZI. RECONSTRUCCION IN SILICO Y POSIBLES FUNCIONES.","resumen":"La vía TOR (?Target Of Rapamycin?) de mamíferos es una red proteica de regulación parauna amplia gama de procesos involucrados en el crecimiento y la diferenciación celular,constituyendo un interruptor funcional entre el metabolismo anabólico y catabólico de lacélula. El Trypanosoma cruzi, agente etiológico de la enfermedad de Chagas, tiene un ciclode vida muy complejo con diferentes estadíos morfológicos en varios hospedadores. Esteciclo de vida implica que los parásitos enfrentan grandes fluctuaciones en el medioextracelular que deben ser detectadas y a las cuales deben responder adaptando sumetabolismo. Un candidato a ser el mediador entre los receptores\/sensores del medio y larespuesta adaptativa celular es la vía TOR. En este trabajo integramos los datosbibliográficos de la vía TOR de organismos tripanosomátidos con un análisis in silico(simulación computacional de procesos o estructuras biológicas) del genoma del parásito.Se proponen además posibles efectores y procesos regulados por esta ruta metabólica.Teniendo en cuenta que existe muy poca información sobre los mecanismos detransducción de señales en tripanosomátidos, consideramos que el mapa presentado eneste trabajo puede ser una referencia para futuros trabajos experimentales.","palabras_clave":"TRYPANOSOMA CRUZI|mTOR|ENFREMEDAD DE CHAGAS|TRANSDUCCION DE SEÑAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89108,"idioma_id":4,"titulo":"The role of Fe(III) modified montmorillonite on fluoride mobility: adsorption experiments and competition with phosphate","resumen":"Fluoride adsorption onto Fe(III) modified montmorillonite was investigated using batch experiments. The effect of reaction time, pH, ionic strength and phosphate, as a competitive anion, was evaluated. Kinetics indicated that adsorption obeys a pseudo-first-order rate law which involves two steps. The fast one (bulk transport\/surface reaction) occurs instantaneously. The slower (diffusion in pores) takes hours to complete. The adsorption rate increases by increasing the fluoride concentration and by decreasing pH. The presence of phosphate reduces fluoride adsorption and reveals that both ions are in competition for surface sites. The reduction in fluoride adsorption when phosphate is present depends on the order of adsorbate addition. The higher fluoride adsorption occurs when both anions are added simultaneously, whereas when either fluoride or phosphate is added first, the fluoride adsorption is lower. The presence of fluoride does not have a measurable effect on phosphate adsorption. The results obtained contribute to our understanding of the mobility of fluoride in surface water which has naturally high levels of fluoride, in both the presence and absence of phosphate.","palabras_clave":"FLUORIDE|PHOSPHATE|COMPETITIVE ADSORPTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89109,"idioma_id":5,"titulo":"Evidencias de trauma en el periodo formativo en el valle de San Francisco, Jujuy, Argentina","resumen":"Las sociedades que vivieron durante el Período Formativo en el noroeste de Argentina, fueron interpretadas como grupos sin diferencias sociales estructurales y con relaciones de interacción entre sí. Esto configura un escenario con ausencia de conflictividad social lo cual se vería reflejado en el registro arqueológico. En este trabajo se presenta el caso de dos individuos procedentes de la región piedemontana de las Yungas de Jujuy, Argentina con cronologías que los adscriben al Período Formativo (800 aC-500 dC), con evidencias de lesiones vitales en el cráneo las cuales dan cuenta de la presencia de violencia interpersonal entre los grupos tradicionalmente denominados San Francisco.","palabras_clave":"Periodo Formativo|Tradicion San Francisco|bioarqueología|violencia interpersonal"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89110,"idioma_id":4,"titulo":"Effect of repeated eCG treatments and ovum pick-up on ovarian response and oocyte recovery during early pregnancy in suckling beef cows","resumen":"This study was designed to evaluate in suckling early pregnant beef cows with and without eCG-pre-stimulation: (i) the influence of day gestation (from 40 to 101 days) and the consecutive eCG treatments on the follicular growth induced by means of ultrasound-guided transvaginal follicle ablation (FA; all follicles &#8805; 5 mm) and the number and quality oocytes recovered by ovum pick-up (OPU) and (ii) the possible effects of repeated hormonal stimulation and FA\/OPU on pregnancy outcome. Twelve suckling early pregnant Angus cows (40 days post fixed-time artificial insemination) were randomly assigned to each of two groups (n=6 group(-1)). Group 1 treatments included: FA (Day 0), eCG (1600 IU; Day 1) and OPU (Day 5). Group 2: as cited Group 1 with no eCG treatment. In both groups, OPU was repeated five times (Days 45, 59, 73, 87 and 101 of gestation). The numbers (mean ± SEM) of class II (5-9 mm; 4.3 ± 0.9) and class III (&#8805;10 mm; 2.5 ± 0.4) follicles visualized per cow per OPU session in eCG-treated cows were greater (P&lt;0.05) than for non-treated cows (0.9 ± 0.1 and 0.9 ± 0.1, respectively). In contrast, the number (mean ± SEM) of class I (&lt;5mm) follicles per cow per OPU session was lower for cows with eCG treatment (2.8 ± 0.4) than for non-treated cows (5.7 ± 0.5). The mean number of aspirated follicles was not significantly different (P&lt;0.05) between eCG-treated cows and non-treated cows at 45 and 59 days of pregnancy. However, the mean number of aspirated follicles was greater (P=0.03) in eCG-treated cows than non-treated cows from 73 day of pregnancy onwards. The numbers (mean ± SEM) of recovered oocytes and viable oocytes\/cow\/session were greater (P&lt;0.05) for eCG-treated cows (2.2 ± 0.2 and 1.6 ± 0.4, respectively) than for non-treated cows (1.0 ± 0.2 and 0.9 ± 0.2, respectively). No donor pregnancies were lost either during or following OPU procedure. We can conclude that (1) eCG-treated pregnant suckled cows can be a source of oocytes for IVF at least to 100 days of gestation and (2) repeated FA\/eCG treatment\/OPU procedures did not affect the pregnancy outcome.","palabras_clave":"Cattle|Early pregnancy|Ovum pick-up|eCG|Oocyte"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89111,"idioma_id":4,"titulo":"Effect of Aqueous Phase Composition on Stability of Sodium Caseinate \/Sunflower oil Emulsions","resumen":"AbstractThe aim of the present work was to investigate the effect of aqueous phase composition on the stability of emulsions formulated with 10 wt% sunflower oil as fat phase. Aqueous phase was formulated with 0.5, 2, or 5 wt% sodium caseinate, or sodium caseinate with the addition of two different hydrocolloids, xanthan gum or locust bean gum, both at 0.3 or 0.5 wt% level or sodium caseinate or with addition of 20 wt% sucrose. Emulsions were processed by Ultra-Turrax and then further homoge-nized by ultrasound. Creaming and flocculation kinetics were quantified by analyzing the samples with a Turbiscan MA 2000. Emulsions were also analyzed for particle size distribution, microstructure, viscosity, and dynamic surface properties. The most stable systems of all selected in the present work were the 0.3 or 0.5 wt% XG or 0.5 wt% LBG\/0.5 wt% NaCas coarse emulsion and the 20 wt% sucrose\/5 wt% NaCas fine emulsion. Surprisingly, coarse emulsions with the lower concentration of NaCas, which had greater D4,3, were more stable than fine emulsions when the aque-ous phase contained XG or LBG. In these conditions, the overall effect was less negative bulk interactions between hydrocolloids and sodium caseinate, which led to stability. Sugar interacted in a positive way, both in bulk and at the interface sites, producing more stable systems for small-droplet high-protein-concentration emulsions. This study shows the relevance of components interactions in micro-structure and stability of caseinate emulsions.","palabras_clave":"EMULIONES|ESTABILIDAD|CASEINATO DE SODIO|HIDROCOLOIDES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89112,"idioma_id":4,"titulo":"Mean Atomic Number Quantitative Assessment in Backscattered Electron Imaging","resumen":"A method for obtaining quantitative mean atomic number images in a scanning electron microscope for different kinds of samples has been developed. The backscattered electron signal is monotonically increasing with the mean atomic number Z, and accordingly Z can be given as a function of the image gray levels. From results obtained from Monte Carlo simulations, an exponential function is fitted to convert the backscattered registered gray levels into a Z image map. Once this fitting was performed, the reproducibility of the Z determination was checked through the acquisition of backscattered electron images from metal and mineral standards. The developed method can be applied to any unknown sample, always controlling the experimental conditions, as shown here for a thin section of a rock in which several unknown mineral phases are present; the results obtained herein are compared to quantitative assessments performed with X-ray spectra from each mineral phase.","palabras_clave":"SEM|Monte Carlo simulation|backscattered electron imaging|energy dispersive analysis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89113,"idioma_id":5,"titulo":"Novedades para el Género Rosellinia (Ascomycota-Xylariaceae) en el noroeste de la República Argentina","resumen":"Se cita por primera vez para el Cono Sur a Rosellinia canzacotoana y para la Argentina a Rosellinia arcuata. Rosellinia necatrix se cita creciendo sobre árboles en descomposición de la flora autóctona de la Argentina. Se realiza una revisión de tres holotipos de Spegazzini: Rosellinia australis, Rosellinia bonaerensis, Rosellinia smilacina, detallando su estado nomenclatural y taxonómico actual. También se presenta una clave dicotómica de las especies con aspecto rosellinoide del Noroeste del país y un mapa de distribución.","palabras_clave":"XYLARIALES|MICOGEOGRAFÍA|YUNGAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89114,"idioma_id":4,"titulo":"First Report of Anthracnose on Fruits of Duchesnea indica Caused by Colletotrichum acutatum in Northwestern Argentina","resumen":"Duchesnea indica (Andrews) Focke, a cosmopolitan wild species related to the cultivated strawberry that is widely distributed in northwestern Argentina, grows in close proximity to strawberry crops and has proven to be almost immune to Colletotrichum spp. isolated from diseased strawberry plants (1), hence it has never been considered a phytopathological risk. During a field survey of ?La Heladera? (27°01&#8242;45&#8243;S, 65°39&#8242;20&#8243;W), Tafí del Valle (Tucumán, Argentina) from November 2009 to November 2010, a genotype of D. indica showing fruits with dark brown, necrotic, irregular, circular lesions of 5 to 20 mm in diameter were collected. Setose acervuli were observed on the center of the fruit lesions. Pathogens were obtained from 10 diseased fruit collected at random, and four fungal isolates were isolated per fruit on potato dextrose agar (PDA). To reduce the number of samples for evaluation, two isolates per fruit that were exhibiting stable but distinctive morphological features were chosen to continue the studies. Isolates were characterized by morphological, molecular, and phytopathological criteria. After 10 days of incubation on PDA medium at 28°C with continuous white light, colonies exhibited a gray, aerial mycelium, whereas the reverse of the colony is a pale maroon with a radial, pale salmon color. Masses of salmon-colored conidia formed in the center of the colonies. Conidia were hyaline, one celled, fusiform, tapered to a point at both ends, and measured 14.8 to 17.3 × 4.5 to 7.4 &#956;m (n = 100). Setae were scarce and sclerotia were absent. All morphological characteristics that were observed indicated that the isolates were C. acutatum (3). To fulfill Koch´s postulates and verify the pathogenicity on commercial varieties of strawberry, six healthy plants of D. indica and Fragaria × ananassa cv. Camarosa with mature fruits were used to test each isolate. Four plants were spray inoculated with conidial suspensions of the virulent isolates (1.5 × 106 conidia\/ml) and two with sterile distilled water as controls. Both treatments were maintained under white light (2,000 lux, 12 h per day) at 28°C and 70% relative humidity. Nine days after the inoculation, dark brown lesions and salmon-colored masses of conidia were observed only in inoculated fruits of both genotypes. The fungus isolated from diseased fruits and the conidia that were produced were identical to the isolates used to inoculate the plants. To confirm pathogen identity, PCR amplification with the species-specific pair of primer CaInt2\/ITS4 (4) were carried out using fungal total DNA from the original isolates and isolates obtained from inoculated fruits. An amplification product of approximately 490 bp, which is specific for C. acutatum, was observed in all DNA samples (4). Although C. acutatum has already been reported in Fragaria × ananassa in Argentina (2), to our knowledge, this is the first report of C. acutaum causing anthracnose in D. indica species. This result is relevant since this species grows close to strawberry fields and can be an alternative host and potential vector of the anthracnose disease agent.","palabras_clave":"Duchesnea indica|Anthracnose|Colletotrichum acutatum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89115,"idioma_id":4,"titulo":"PARTICIPATION OF IP3R, RYR AND L-TYPE Ca2+ CHANNEL IN THE NUCLEAR MATURATION OF RHINELLA ARENARUM OOCYTES","resumen":"During meiosis resumption, oocytes undergo a series of nuclear and cytosolic changes that preparethem for fertilization and that are referred to as oocyte maturation. These events are characterizedby germinal vesicle breakdown (GVBD), chromatin condensation and spindle formation and, amongcytosolic changes, organelle redistribution and maturation of Ca2+-release mechanisms. The progressionof the meiotic cell cycle is regulated by M phase\/maturation-promoting factor (MPF) and mitogenactivatedprotein kinase (MAPK). Changes in the levels of intracellular free Ca2+ ion have also beenimplicated strongly in the triggering of the initiation of the M phase. Ca2+ signals can be generatedby Ca2+ release from intracellular Ca2+ stores (endoplasmic reticulum; ER) or by Ca2+ influx from theextracellular space. In this sense, the L-type Ca2+ channel plays an important role in the incorporationof Ca2+ from the extracellular space. Two types of intracellular Ca2+ receptor\/channels are knownto mediate the intracellular Ca2+ release from the ER lumen. The most abundant, the inositol 1,4,5-trisphosphate receptor (IP3R), and the other Ca2+ channel, the ryanodine receptor (RyR), have alsobeen reported to mediate Ca2+ release in several oocytes. In amphibians, MPF and MAPK play acentral role during oocyte maturation, controlling several events. However, no definitive relationshipshave been identified between Ca2+ and MPF or MAPK. We investigated the participation of Ca2+in the spontaneous and progesterone-induced nuclear maturation in Rhinella arenarum oocytes andthe effect of different pharmacological agents known to produce modifications in the Ca2+ channels.We demonstrated that loading competent and incompetent oocytes with the intracellular calciumchelator BAPTA\/AM produced suppression of spontaneous and progesterone-induced GVBD. In ourresults, the capacity of progesterone to trigger meiosis reinitiation in Rhinella in the presence of L-typeCa2+ channel blockers (nifedipine and lanthane) indicated that spontaneous and progesterone-inducedmaturation would be independent of extracellular calcium influx, but would be sensitive to intracellularCa2+ deprivation. As demonstrated by the effect of thimerosal and heparin in Rhinella arenarum, theintracellular increase in Ca2+ during maturation is alsomediated mainly by IP3R. In addition, our resultsusing caffeine, an agonist of the RyR, could suggest that Ca2+ release from ryanodine-sensitive storesis not essential for oocyte maturation in Rhinella. The decrease in MPF activity with NaVO3 negativelyaffected the percentage of thimerosal-induced GVBD. This finding suggests that Ca2+ release through theIP3R could be involved in the signalling pathway that induces MPF activation. However, the inhibitionof MAP\/ERK kinase (MEK) by PD98128 or P90 by geldanamycin produced a significant decrease in thepercentages of GVBD induced by thimerosal. This finding suggests that Ca2+ release per se cannot bypassthe inhibition of the MAPK activity.","palabras_clave":"AMPHIBIAN|Ca++ CHANELS|OOCYTE MATURATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89116,"idioma_id":4,"titulo":"EFFECT ON SPERM QUALITY OF DIFFERENT CRYOPROTECTANS IN SPERM OF Chinchilla lanigera","resumen":"Chinchilla lanigera is an endangered species therefore the development of cryopreservation protocols for its gametes is a useful tool in the application of assisted reproduction techniques. A study of thefunctionality of the spermatozoa punctured from the cauda epididymis was performed on fresh orfrozen\u2013thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). Theeffect that these media had on sperm physiology during the freezing, storage and later thawing processwas analysed. A decrease in the percentages of viability, motility, membrane integrity and capacityto undergo the induced acrosome reaction was found with all the media assayed, an increase in thepercentages of DNA fragmentation was also observed. The comparative analysis of the effect of thedifferent cryoprotectants assayed showed that the best medium to use to cryopreserve epididymalsperm in this species is test-yolk buffer. This medium had the least effect on the abovementionedphysiological parameters, especially at the level of genetic material.for its gametes is a useful tool in the application of assisted reproduction techniques. A study of thefunctionality of the spermatozoa punctured from the cauda epididymis was performed on fresh orfrozen\u2013thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). Theeffect that these media had on sperm physiology during the freezing, storage and later thawing processwas analysed. A decrease in the percentages of viability, motility, membrane integrity and capacityto undergo the induced acrosome reaction was found with all the media assayed, an increase in thepercentages of DNA fragmentation was also observed. The comparative analysis of the effect of thedifferent cryoprotectants assayed showed that the best medium to use to cryopreserve epididymalsperm in this species is test-yolk buffer. This medium had the least effect on the abovementionedphysiological parameters, especially at the level of genetic material.for its gametes is a useful tool in the application of assisted reproduction techniques. A study of thefunctionality of the spermatozoa punctured from the cauda epididymis was performed on fresh orfrozen\u2013thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). Theeffect that these media had on sperm physiology during the freezing, storage and later thawing processwas analysed. A decrease in the percentages of viability, motility, membrane integrity and capacityto undergo the induced acrosome reaction was found with all the media assayed, an increase in thepercentages of DNA fragmentation was also observed. The comparative analysis of the effect of thedifferent cryoprotectants assayed showed that the best medium to use to cryopreserve epididymalsperm in this species is test-yolk buffer. This medium had the least effect on the abovementionedphysiological parameters, especially at the level of genetic material.for its gametes is a useful tool in the application of assisted reproduction techniques. A study of thefunctionality of the spermatozoa punctured from the cauda epididymis was performed on fresh orfrozen\u2013thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). Theeffect that these media had on sperm physiology during the freezing, storage and later thawing processwas analysed. A decrease in the percentages of viability, motility, membrane integrity and capacityto undergo the induced acrosome reaction was found with all the media assayed, an increase in thepercentages of DNA fragmentation was also observed. The comparative analysis of the effect of thedifferent cryoprotectants assayed showed that the best medium to use to cryopreserve epididymalsperm in this species is test-yolk buffer. This medium had the least effect on the abovementionedphysiological parameters, especially at the level of genetic material.is an endangered species therefore the development of cryopreservation protocols for its gametes is a useful tool in the application of assisted reproduction techniques. A study of thefunctionality of the spermatozoa punctured from the cauda epididymis was performed on fresh orfrozen\u2013thawed samples with three cryoprotective media (test-yolk buffer, sucrose and glycerol). Theeffect that these media had on sperm physiology during the freezing, storage and later thawing processwas analysed. A decrease in the percentages of viability, motility, membrane integrity and capacityto undergo the induced acrosome reaction was found with all the media assayed, an increase in thepercentages of DNA fragmentation was also observed. The comparative analysis of the effect of thedifferent cryoprotectants assayed showed that the best medium to use to cryopreserve epididymalsperm in this species is test-yolk buffer. This medium had the least effect on the abovementionedphysiological parameters, especially at the level of genetic material.","palabras_clave":"CHINCHILLA|EPYDIDIMAL SPERM|CRYOPRESERVATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89117,"idioma_id":4,"titulo":"The skew-torsion holonomy theorem and naturally reductive spaces","resumen":"We prove a Simons-type holonomy theorem for totally skew 1-forms with values  in a Lie algebra of linear isometries. The only transitive case, for this  theorem, is the full orthogonal group. We only use geometric methods and we do  not use any classification (not even that of transitive isometric actions on  the sphere or the list of rank one symmetric spaces). This result was  independently proved, by using an algebraic approach, by Paul-Andy Nagy. We  apply this theorem to prove that the canonical connection of a compact  naturally reductive space is unique, provided the space does not split off,  locally, a sphere or a compact Lie group with a bi-invariant metric. From this  it follows easily how to obtain the full isometry group of a naturally  reductive space. This generalizes known classification results of Onishchick,  for normal homogeneous spaces with simple group of isometries, and Shankar, for  homogeneous spaces of positive curvature. This also answers a question posed by  J. Wolf and Wang-Ziller. Namely, to explain why the presentation group of an  isotropy irreducible space, strongly or not, cannot be enlarged (unless for  spheres, or for compact simple Lie groups with a bi-invariant metric).","palabras_clave":"HOLONOMY|SKEW-TORSION|NATURALLY REDUCTIVE|ISOMETRY GROUP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89118,"idioma_id":4,"titulo":"Araucaria araucana tree-ring chronologies in Argentina: spatial growth variations and climate influences","resumen":"Seventeen tree-ring chronologies from the conifer Araucaria araucana (Molina) K. Koch have been analyzed across its range of distribution in Argentina. We studied the growth patterns and determined the main climatic factors influencing A. araucana radial growth. All the chronologies show a strong common signal observed by the high amount of variance explained by the first principal component (PC1) and the high mean correlation (r = 0.597) between the chronologies over the 1676\u20131974 interval. On this basis, we developed a regional chronology that is 866 years long (A.D. 1140\u20132006) and includes 621 tree-ring series. Based on the PC2 scores, chronologies were clearly separated by elevation in high- and low-elevation records. Regional tree growth is strongly negatively related to temperatures during summer and fall in the previous-growing season and spring in the current-growing season, respectively. A positive association of tree growth with precipitation is recorded during spring in the current growing season. These results suggest a close relationship between A. araucana tree growth and water availability on a regional scale. This observation is also consistent with a positive and significant correlation between our A. araucana regional record and a reconstruction of November\u2013December rainfall for northern Patagonia inferred from the xeric Austrocedrus chilensis during the past 400 years. Negative correlations between A. araucana regional growth and the sea surface temperature in the Niño 3.4 region reflect the occurrence of above-mean summer temperatures in the region during positive tropical Pacific SST anomalies. The negative relationship with the Antarctic Oscillation (AAO) results from reduced precipitation in our study region during the positive phase of the AAO. The effect of elevation on water availability is consistent with significant correlations between ring-width variations at lower elevations and the Palmer Drought Severity Index during spring and summer in the current growing season. Our study emphasizes the high dendroclimatological potential of A. araucana chronologies for reconstructing past climate variations in northern Patagonia during the past millennium.&nbsp;","palabras_clave":"growth patterns|PCA|northern Patagonia|ENSO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89119,"idioma_id":4,"titulo":"Spatiotemporal analysis of channel wall erosion in ephemeral torrents using tree roots: An example from the Patagonian Andes","resumen":"This paper presents absolute ages for flash floods and related sediment entrainment in headwater catchments to construct a spatiotemporal framework of process dynamics and locations of major areas of  channel wall erosion. The most reliable method for datingerosion is through dendrogeomorphic studies of exposed tree roots. Based on the analysis of erosion signals in root-ring records we documented a time series of channel wall erosion and successfully dated 21 erosive fl ash fl ood events since A.D. 1870 in an ephemeral gully in the Patagonian Andes. The study was performed with roots from Austrocedrus chilensis, Nothofagus dombeyi, and Pseudotsuga menziesii. Results demonstrate the potential of root analyses for the determination of major areas of sediment entrainment. In addition, we show that the position of damage within individual root rings allows inferences about the seasonal timing of fl ash flood effects and thus an assessment of possible meteorological triggers of erosive events, short intense storms occurring primarily in austral fall and late winter in this case. The approach presented adds significantly to the documentation of sediment entrainment and facilitates identification of areas of rapid erosion in small, remote headwater catchments with ephemeral fl ash flood activity.","palabras_clave":"flash flood|channel erosion|dendrogeomorphology|northern Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89120,"idioma_id":4,"titulo":"Snowpack variations since AD 1150 in the Andes of Chile and Argentina (30-37 S) inferred from rainfall, tree-ring and documentary records","resumen":"The Andean snowpack is the main source of freshwater and arguably the single most important natural resource for the populated, semi-arid regions of central Chile and central-western Argentina. However, apart from recent analyses of instrumental snowpack data, very little is known about the long term variability of this key natural resource. Here we present two complementary, annually-resolved reconstructions of winter snow accumulation in the southern Andes between 30°\u201337°S. The reconstructions cover the past 850 years and were developed using simple regression models based on snowpack proxies with different inherent limitations. Rainfall data from central Chile (very strongly correlated with snow accumulation values in the adjacent mountains) were used to extend a regional 1951\u20132010 snowpack record back to AD 1866.  Subsequently, snow accumulation variations since AD 1150 were inferred from precipitation-sensitive tree-ring width series. The reconstructed snowpack values were validated with independent historical and instrumental information. An innovative time series analysis approach allowed the identification of the onset, duration and statistical significance of the main intra- to multi-decadal patterns in the  reconstructions and indicates that variations observed in the last 60 years are not particularly anomalous when assessed in a multi-century context. In addition to providing new information on past variations for a highly relevant hydroclimatic variable in the southern Andes, the snowpack reconstructions can also be used to improve the understanding and modeling of related, larger-scale atmospheric features such as ENSO and the PDO.","palabras_clave":"snowpack|Central Andes|tree rings|climate reconstruction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89121,"idioma_id":4,"titulo":"Precipitation changes in the South American Altiplano since 1300AD reconstructed by tree-rings","resumen":"Throughout the second half of the 20th century,  the Central Andes has experienced significant climatic and  environmental changes characterized by a persistent warming  trend, an increase in elevation of the 0 C isotherm, and  sustained glacier shrinkage. These changes have occurred  in conjunction with a steadily growing demand for water resources.  Given the short span of instrumental hydroclimatic  records in this region, longer time span records are needed to  understand the nature of climate variability and to improve  the predictability of precipitation, a key factor modulating  the socio-economic development in the South American Altiplano  and adjacent arid lowlands. In this study we present  the first quasi-millennial, tree-ring based precipitation reconstruction  for the South American Altiplano. This annual  (November?October) precipitation reconstruction is based  on the Polylepis tarapacana tree-ring width series and represents  the closest dendroclimatological record to the Equator  in South America. This high-resolution reconstruction  covers the past 707 yr and provides a unique record characterizing  the occurrence of extreme events and consistent  oscillations in precipitation. It also allows an assessment  of the spatial and temporal stabilities of the teleconnections  between rainfall in the Altiplano and hemispheric forcings  such as El Ni?no-Southern Oscillation. Since the 1930s to  present, a persistent negative trend in precipitation has been recorded in the reconstruction, with the three driest years  since 1300AD occurring in the last 70 yr. Throughout the  707 yr, the reconstruction contains a clear ENSO-like pattern  at interannual to multidecadal time scales, which determines  inter-hemispheric linkages between our reconstruction and  other precipitation sensitive records modulated by ENSO in  North America. Our reconstruction points out that centuryscale  dry periods are a recurrent feature in the Altiplano climate,  and that the future potential coupling of natural and  anthropogenic-induced droughts may have a severe impact  on socio-economic activities in the region. Water resource  managers must anticipate these changes in order to adapt to  future climate change, reduce vulnerability and provide water  equitably to all users.","palabras_clave":"SOUTH AMERICAN ALTIPLANO|PRECIPITATION RECONSTRUCTION|POLYLEPIS TARAPACANA|TREE RING PROXY RECORD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89122,"idioma_id":5,"titulo":"Aislamiento, cultivo e identificación de microorganismos ambientales a partir de muestras naturales","resumen":"se emplearán muestras naturales (agua, suelo, sedimentos de ríos o lagos,  heces, etc.) a partir de las cuales se aislaran microrganismos cultivables, principalmente   bacterias, mediante el empleo de medios selectivos. Posteriormente se procederá a la   identificación por características morfológicas y patrones fisiológicos particulares.","palabras_clave":"BACTERIAS|ALGAS|HONGOS|AISLAMIENTO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89123,"idioma_id":4,"titulo":"Biodiversity of Xylariaceae (Ascomycota) and their hosts in protected areas from Tucuman (Argentina)","resumen":"Fourty nine species belonging to the genera Astrocystis, Biscogniauxia, Daldinia, Entonaema, Hypoxylon, Kretzschmaria, Phylacia, Poronia, Rosellinia, Stilbohypoxylon and Xylaria were recorded in protected areas from Tucumán. The species are grouped in endemic, cosmopolitan, neotropical and pantropical. The biodiversity of Xylariaceae in this province is compared with those from other countries. Twenty-three host taxa are registered, most of them were dicots. Cinnamomum porphyrium and Podocarpus parlatorei were the two native hosts more colonized. ","palabras_clave":"ARGENTINA|MYCOGEOGRAFIA|XYLARIALES|YUNGAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89124,"idioma_id":4,"titulo":"Experimental and numerical study of the role of crystallographic texture on th eformability of an electro-galvanized steel sheet","resumen":"In this work, the influence of plastic anisotropy on forming-limit strains for a drawing-quality steel sheetwas investigated. For this purpose, hourglass-type samples, taken at 0&#9702;, 45&#9702; and 90&#9702; with respect to thesheet rolling direction were tested with a typical punch and die fixturing. Numerical simulations werecarried out in order to validate two viscoplastic (VP) polycrystalline models, self-consistent (SC) and fullconstraintTaylor-type (FC), in conjunction with the Marciniak and Kuczynski (MK) localization approach.The observed shift to the right in the minimum of the forming limit diagram (FLD), inherent to Nakazimatest, was taken into account in the simulations. Keeping the set of adjustable parameters to a minimumin the calibration of the viscoplastic polycrystal model, only the material\u2019s initial texture and a powerlaw fit to the tensile data needed to be measured. Without other adjustments to either model, MK-VPSCgives realistic predictions over the entire FLD, while the MK-FC predictions only follow the measuredlimit curve on the tensile side of plane strain. In the positive biaxial quadrant of the FLD, MK-FC predictsunrealistic high limit values. It was found that, despite these extremely high limit values, the similarityin the measured limit strains for the three sample orientations is captured by both models. However, aconsistency in the MK-VPSC predictions indicates that this model seems to be a more suitable tool fordescribing the role of crystallographic texture on the sheet metal forming processes.","palabras_clave":"FORMING LIMITS|ANISOTROPY|TEXTURE|MK-VPSC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89125,"idioma_id":4,"titulo":"Metabolic oligosaccharide engineering of Plasmodium falciparum intraerythrocytic stages allows direct glycolipid analysis by mass spectrometry","resumen":"AbstractA recent addition to the arsenal of tools for glycome analysis is the use of metabolic labels that allow covalent tagging of glycans with imaging probes. In this work we show that N-azidoglucosamine was successfully incorporated into glycolipidic structures of Plasmodium falciparum intraerythrocytic stages. The ability to tag glycoconjugates selectively with a fluorescent reporter group permits TLC detection of the glycolipids providing a new method to quantify dynamic changes in the glycosylation pattern and facilitating direct mass spectrometry analyses. Presence of glycosylphosphatidylinositol and glycosphingolipid structures was determined in the different extracts. Furthermore, the fluorescent tag was used as internal matrix for the MALDI experiment making even easier the analysis.","palabras_clave":"Metabolic oligosaccharide engineering|Plasmodium falciparum| mass spectrometry|glycolipid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89126,"idioma_id":4,"titulo":"'Structural and immunological characterization of sulfatides: Relevance of sulfate moieties in Trypanosoma cruzi Glycoconjugates'","resumen":"\u2022\t'Structural and immunological characterization of sulfatides: Relevance of sulfate moieties in Trypanosoma cruzi Glycoconjugates' Diana M Acosta, Luciana L. Soprano, Maximiliano Ferrero, Mónica I. Esteva, Adelina Riarte, Alicia S. Couto and Vilma G. Duschak. Parasite immunology, 2012 Nov; 34 (11): 499-510.","palabras_clave":"Sulfatides|Trypanosoma cruzi|glycoconjugates"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89127,"idioma_id":4,"titulo":"Characterization of lipid a profiles from Shigella flexneri variant X lipopolysaccharide","resumen":"RATIONALE: In developing countries, Shigella flexneri (Sf) is the major causative agent of the endemic shigellosis  (bacillary dysentery) responsible annually for one million fatalities mostly among infants. Lipopolysaccharides (LPSs)  are characteristic components of the outer membrane of the overwhelming majority of Gram-negative bacteria.  Since lipid A is essential for the viability of the Gram-negative bacteria, it is subject to extensive chemical studies with  new analytical techniques.  METHODS: Lipid A was released by mild acid hydrolysis from the lipopolysaccharide which was obtained via the  phenol\/water extraction, purified and analyzed by matrix-assisted laser desorption\/ionization time-of-flight mass  spectrometry (MALDI-TOF-MS) and matrix-assisted laser desorption\/ionization laser-induced dissociation tandem  mass spectrometry (MALDI-LID-MS\/MS).  RESULTS: A detailed structural study of the whole lipid A obtained from S. flexneri variant X was carried out for the  first time. Thus, we have shown that lipid A is a heterogeneous mixture having different numbers of acylated and  phosphoethanolamine groups attached to the diglucosamine backbone. Furthermore, we found in the phenol phase an  unusual hepta-acylated lipid A species, although the abundance was very low.  CONCLUSIONS: MALDI-TOF-MS allowed us to unravel the lipid A heterogeneity, which was not previously reported in  Sf LPS. It is well known that slight variations of the chemical structure of lipid A may change its biological activity. Thus,  the knowledge of the detailed chemical structure represents an essential step for further development of new preventive  or therapeutically active compounds. Copyright © 2012 John Wiley & Sons, Ltd.","palabras_clave":"LIPID A|MALDI-TOF-MS|SHIGELLA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89128,"idioma_id":4,"titulo":"An anionic synthetic sugar containing 6-SO(3) -NAcGlc mimics the sulfated cruzipain epitope that plays a central role in immune recognition.","resumen":"Cruzipain (Cz), the major cysteine proteinase of Trypanosoma cruzi, is a glycoprotein that contains sulfated high-mannose-type oligosaccharides. We have previously determined that these sulfate groups are targets of specific immune responses. In order to evaluate the structural requirements for antibody recognition of Cz, a systematic structure-activity study of the chemical characteristics needed for antibody binding to the Cz sulfated epitope was performed by immunoassays. With this aim, different synthesized molecules were coupled to the proteins BSA and aprotinin and confronted with (a) mouse sera specific for Cz and its carboxy-terminal (C-T) domain, (b) antibodies raised in rabbits immunized with Cz and its C-terminal domain and (c) IgGs purified from human Chagas disease sera. Our results indicate that a glucosamine containing an esterifying sulfate group in position O-6 and an N-acetyl group was the preferred epitope for the immune recognition of sera specific for Cz and its C-T domain. Although to a minor extent, other anionic compounds bearing sulfate groups in different positions and number as well as different anionic charged groups including carboxylated or phosphorylated monosaccharides, disaccharides and oligosaccharides were recognized. In conclusion, we found that synthetic anionic sugar conjugates containing N-acetyl d-glucosamine-6-sulfate sodium salt (GlcNAc6S) competitively inhibit the binding of affinity purified rabbit anti-C-T IgG to the C-T extension of Cz. Extending these findings to the context of natural infection, immune assays performed with Chagas disease serum confirmed that the structure of synthetic GlcNAc6S mimics the N-glycan-linked sulfated epitope displayed in the C-T domain of Cz.","palabras_clave":"sugar|6-SO3 -NAcGlc |sulfated |cruzipain"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89129,"idioma_id":4,"titulo":"VVV DR1: The first data release of the Milky Way bulge  and southern plane from the near-infrared ESO public survey VISTA variables in the Via Lactea","resumen":"Context. The ESO Public Survey VISTA Variables in the Vía Láctea (VVV) started in 2010. VVV targets 562 sq. deg in the Galactic bulge andan adjacent plane region and is expected to run for &#8764; 5 years.Aims. In this paper we describe the progress of the survey observations in the first observing season, the observing strategy and quality of the data obtained.Methods. The observations are carried out on the 4-m VISTA telescope in the ZY JHKs filters. In addition to the multi-band imaging the variabilitymonitoring campaign in the Ks filter has started. Data reduction is carried out using the pipeline at the Cambridge Astronomical Survey Unit. The photometric and astrometric calibration is performed via the numerous 2MASS sources observed in each pointing.Results. The first data release contains the aperture photometry and astrometric catalogues for 348 individual pointings in the ZY JHKs filterstaken in the 2010 observing season. The typical image quality is &#8764; 0. &#8242;&#8242;9 &#8722; 1. &#8242;&#8242;0. The stringent photometric and image quality requirements of thesurvey are satisfied in 100% of the JHKs images in the disk area and 90% of the JHKs images in the bulge area. The completeness in the Z andY images is 84% in the disk, and 40% in the bulge. The first season catalogues contain 1.28 × 108 stellar sources in the bulge and 1.68 × 108 inthe disk area detected in at least one of the photometric bands. The combined, multi-band catalogues contain more than 1.63 × 108 stellar sources.About 10% of these are double detections due to overlapping adjacent pointings. These overlapping multiple detections are used to characterisethe quality of the data. The images in the JHKs bands extend typically &#8764; 4 mag deeper than 2MASS. The magnitude limit and photometric qualitydepend strongly on crowding in the inner Galactic regions. The astrometry for Ks = 15 &#8722; 18 mag has rms &#8764; 35 &#8722; 175 mas.Conclusions. The VVV Survey data products offer a unique dataset to map the stellar populations in the Galactic bulge and the adjacent planeand provide an exciting new tool for the study of the structure, content and star formation history of our Galaxy, as well as for investigations ofthe newly discovered star clusters, star forming regions in the disk, high proper motion stars, asteroids, planetary nebulae, and other interestingobjects.","palabras_clave":"Galaxy: bulge|Galaxy: disk|Galaxy: stellar content  |stars: abundances"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89130,"idioma_id":4,"titulo":"Tailoring Population Inversion in Landau-Zener-Stuckelberg Interferometry of Flux Qubits","resumen":"We distinguish different mechanisms for population inversion in flux qubits driven by dc + ac magneticfields. We show that for driving amplitudes such that there are Landau-Zener-Stuckelberg interferences, itis possible to have population inversion solely mediated by the environmental bath. Furthermore, we findthat the degree of population inversion can be controlled by tailoring a resonant frequency Wp in theenvironmental bath. To observe these effects experiments should be performed for long driving times afterfull relaxation.","palabras_clave":"Landau-Zener-Stuckelberg interferences|Dissipation|Population inversion|Flux Qubit"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89131,"idioma_id":4,"titulo":"On completeness of integral manifolds of nullity distributions","resumen":"We give a conceptual proof of the fact that if M is a complete submanifold of a space form, then the maximal integral manifolds of the nullity distribution of its second fundamental form through points of minimal index of nullity are complete.","palabras_clave":"NULLITY DISTRIBUTION|COMPLETENESS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89132,"idioma_id":4,"titulo":"(-)-Epicatechin prevents TNF-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes","resumen":"Obesity is major public health concern worldwide and obese individuals exhibit a higher risk of chronic diseases such as type 2 diabetes. Inflammation plays a significant role in metabolic regulation and mounting evidence highlight the contribution of adipose tissue to systemic inflammatory state. Food extracts with a high content of (_)-epicatechin have been found to exert systemic anti-inflammatory actions, however the anti-inflammatory actions of (_)-epicatechin on adipose tissue remain to be determined. The aim of this study was to investigate the capacity of (_)-epicatechin to prevent tumor necrosis alpha (TNFa)-induced activation of cell signals involved in inflammation and insulin resistance (NF-jB, mitogen-activated protein kinases (MAPKs), AP-1, and peroxisome proliferator activated receptor c (PPARc)) in differentiated white adipocytes (3T3-L1). TNFa triggered the activation of transcription factors NF-jB and AP-1, and MAPKs ERK1\/2, JNK, and p38. (_)-Epicatechin caused a dose (0.5\u201310 lM)- dependent decrease in TNFa-mediated JNK, ERK1\/2, and p-38 phosphorylation, and nuclear AP-1-DNA binding. (_)-Epicatechin also inhibited TNFa-triggered activation of the NF-jB signaling cascade, preventing TNFa-mediated p65 nuclear transport and nuclear NF-jB-DNA binding. (_)-Epicatechin also attenuated the TNFa-mediated downregulation of PPARc expression and decreased nuclear DNA binding. Accordingly, (_)-epicatechin inhibited TNFa-mediated altered transcription of genes (MCP-1, interleukin-6, TNFa, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling. In conclusion, (_)-epicatechin can attenuate TNFa-mediated triggering of signaling cascades involved in inflammation and insulin resistance.","palabras_clave":"ADIPOCYTES|EPICATECHIN|INFLAMMATION|INSULIN RESISTANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89133,"idioma_id":4,"titulo":"Apoptosis of Endothelial Progenitor Cells in a Metabolic Syndrome Experimental Model","resumen":"AIM:   This study tests the hypothesis postulating that metabolic syndrome induced by chronic administration of fructose to spontaneously hypertensive rats (FFHR) generates impairment in vascular repair by endothelial progenitor cells (EPC).  MATERIALS AND METHODS:   TO CHARACTERIZE THE VASCULAR ADVERSE ENVIRONMENT PRESENT IN THIS EXPERIMENTAL MODEL WE MEASURED: NAD(P)H oxidase activity, eNOS activity, presence of apoptosis in the arterial wall, all these parameters were most affected in the FFHR group. Also, we found decreased level and proliferative capacity of EPC measured by flow cytometry and colonies forming units assay in cultured cells, respectively, in both groups treated with fructose; FFHR (SHR fructose fed rats) and FFR (WKY fructose fed rats) compared with their controls; SHR and WKY.  RESULTS:   The fructose-fed groups FFR and SHR also showed an incremented number of apoptotic (annexinV+\/7AADdim) EPC measured by flow cytometry that returns to almost normal values after eliminating fructose administration.  CONCLUSION:   Our findings suggest that increased apoptosis levels of EPC generated in this experimental model could bein part the underlying cause for the impaired vascular repair by in EPC.","palabras_clave":"ENDOTHELIAL PROGENITORS CELLS|METABOLIC SYNDROME|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89134,"idioma_id":4,"titulo":"Flavonoids and metabolic syndrome","resumen":"Increasing evidence indicates that several mechanisms, associated or not with antioxidant actions, are involved in the effects of flavonoids on health. Flavonoid-rich beverages, foods, and extracts, as well as pure flavonoids are studied for the prevention and\/or amelioration of metabolic syndrome (MS) and MS-associated diseases. We summarize evidence linking flavonoid consumption with the risk factors defining MS: obesity, hypertriglyceridemia, hypercholesterolemia, hypertension, and insulin resistance. Nevertheless, a number of molecular mechanisms have been identified; the effects of flavonoids modifying major endpoints of MS are still inconclusive. These difficulties are explained by the complex relationships among the risk factors defining MS, themultiple biological targets controlling these risk factors, and the high number of flavonoids (including theirmetabolites) present in the diet and potentially responsible for the in vivo effects. Consequently, extensive basic and clinical research is warranted to assess the final relevance of flavonoids for MS in&nbsp;vivo effects.       ","palabras_clave":"POLYPHENOLS|INFLAMMATION|OBESITY|HYPERTENSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89135,"idioma_id":4,"titulo":"Subtyping of STEC by MLVA in Argentina","resumen":"Shigatoxin-producing Escherichia coli(STEC) causes serious human illness such as hemolytic uremic síndrome (HUS).Argentina has the world?s highest rate of this syndrome, which is the leading causeof acute renal failure among children. E. col iO157:H7is the most common cause of HUS, but a substantial and growing proportion of thisillness is caused by infection due to non-O157 strains. Multiple-locus variablenumber tandem repeat analysis (MLVA) has become an established technique to subtypeSTEC. This review will address the use of routine STEC subtyping by MLVA in orderto type this group of isolates and to get insight into the genetic diversity ofSTEC. With regard to these objectives we modified and adapted two MLVA protocols,one exclusive for O157 and the other, a generic E. coli assay.A total of 202 STEC isolates, from different sources and corresponding to 20 serotypes,have been MLVA genotyped in our laboratory. In our experience, MLVA constitutesa very sensitive tool and enables us to perform an efficient STEC subtyping. Thediversity found in many serotypes may be useful for future epidemiological studiesof STEC clonality, applied to O157 as well as to non-O157 isolates.","palabras_clave":"STEC|MLVA|genotyping|O157:H7,non-O157"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89136,"idioma_id":4,"titulo":"DNA Immunization Against Proacrosin Impairs Fertility in Male Mice","resumen":"PROBLEM:   Evaluation of proacrosin\/acrosin ability to induce   an immune response in male mice after genetic immunization and   assessment of animal fertility.  METHOD OF STUDY:   Mice   received 50&nbsp;&#956;g per animal of a plasmid containing the human proacrosin   cDNA (pSF2-Acro) (control: empty plasmid, pSF2). The humoral response   was evaluated by ELISA and immunocytochemistry. In vivo fertility was   assessed by mating immunized males with control females. The effect of   antibodies upon Ca(+2) -ionophore-induced acrosomal exocytosis (AE) and   in vitro sperm-zona pellucida (ZP) binding was also studied.  RESULTS:   pSF2-Acro-immunized   mice developed high levels of specific antibodies (P&nbsp;&lt;&nbsp;0.05) that   recognized the sperm acrosomal cap. The number of fertile mice was lower   (P&nbsp;=&nbsp;0.027) in pSF2-Acro-immunized animals than in controls. Litter   size was smaller (P&nbsp;&lt;&nbsp;0.05) in the pSF2-Acro group compared with   controls. A negative correlation (P&nbsp;&lt;&nbsp;0.05) between antibody levels   and litter size was found. Antiproacrosin\/acrosin antibodies inhibited   sperm-ZP binding (P&nbsp;&lt;&nbsp;0.0001) and Ca(+2) -ionophore-induced AE   (P&nbsp;&lt;&nbsp;0.05).  CONCLUSION:   DNA immunization against   proacrosin elicits an immune response in male mice associated with   abnormal sperm functions and reduced fertility.","palabras_clave":"acrosomal exocytosis|fertilization|genetic immunization|infertility|proacrosin\/acrosin|sperm antigens|zona pellucida"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89137,"idioma_id":4,"titulo":"Schizymenia dubyi (Rhodophyta, Schizymeniaceae), a new introduced species in Argentina","resumen":"Schizymenia dubyi (Chauvin ex Duby) J. Agardh is a red alga of the order Nemastomatales that  is native to Europe, Asia and Oceania. The first specimen of this seaweed from the Argentinian  coast was collected in the Chapadmalal intertidal wave-cut platform (38º  12 S, 57º 40 W) in  September 2008. Taxonomic identification of the species was made on the basis of vegetative  and reproductive characters and confirmed by DNA sequence analysis of the rbcL gene. The  S. dubyi samples collected in the field were represented by foliose gametophytes as well as  crustose tetrasporophytes. The gametophytes were distributed in patches of c. 50% coverage of  the analysed quadrants (n20). Gametophyte abundance was 3.1 ± 2.5 (mean ± SD) plants per  quadrant (0.04 m2). All these were fertile females. Molecular results placed the specimens from  Argentina within the S. dubyi clade, closely related to S. dubyi from Japan and France.","palabras_clave":"intertidal|invasive species|molecular analysis|Nemastomatales"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89138,"idioma_id":4,"titulo":"Catalytic and physicochemical characterization of the MnVOx system. Influence of vanadium on methanol oxidation","resumen":"Manganese and mixed vanadium oxides were prepared by the hydrolysis of acetylacetonates. They were characterized by different techniques, such as X-ray diffraction, XPS, temperature-programmed surface reaction (TPSR), and conversion and selectivity measurements. TPSR studies showed that H2O, CO2, and O2 are present in manganese oxide samples and that the ones containing vanadium desorb CO2, H2O, methanol, formaldehyde, O2. The vanadium-free catalysts and the ones with a lower vanadium content also exhibit high methanol conversion and selectivity to CO2 at higher temperatures. The selectivity to dimethyl ether is important in the catalyst without V at lower temperature. The greatest conversion at lower temperatures and the highest selectivities to CO2 are achieved with the catalysts having the highest vanadium content.2O, CO2, and O2 are present in manganese oxide samples and that the ones containing vanadium desorb CO2, H2O, methanol, formaldehyde, O2. The vanadium-free catalysts and the ones with a lower vanadium content also exhibit high methanol conversion and selectivity to CO2 at higher temperatures. The selectivity to dimethyl ether is important in the catalyst without V at lower temperature. The greatest conversion at lower temperatures and the highest selectivities to CO2 are achieved with the catalysts having the highest vanadium content.","palabras_clave":"Manganese oxide \u0002  \u0002|\u0002 Vanadium oxide |Vanadates|Methanol TPSR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89139,"idioma_id":4,"titulo":"Structural and transport characterization of ultra thin Ba0.05Sr0.95TiO3 layers grown over Nb electrodes for the development of Josephson junctions","resumen":"A phenomenological approach was used to obtain critical information about the structure and electrical properties of ultra thin Ba0.05Sr0.95TiO3 (BSTO) layers over Nb electrodes. The applied method allows in a direct and simple way, to study and to optimize the growth of the barrier in order to improve the performance and application of Josephson junctions (JJ). A very good control of the layer thickness with a low roughness (~ 0.35 nm) was achieved during the deposition process. The BSTO layers present an energy barrier of 0.6 eV and an attenuation length of 0.4nm, indicating its good insulating properties for the development of JJ with improved performance and functionality.","palabras_clave":"Josephson Junction|tunneling |CAFM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89140,"idioma_id":5,"titulo":"Rasgos biológicos de macroinvertebrados de ríos subtropicales: patrones de variación a lo largo de gradientes ambientales espacio-temporales","resumen":"Los rasgos biológicos reflejan las tácticas de los organismos como respuesta al cambio ambiental. Analizamos la organización funcional del grupo EPT (Ephemeroptera, Plecoptera y Trichoptera) en una cuenca subtropical de montaña para evaluar si sus rasgos biológicos están asociados con patrones espacio-temporales de variación ambiental y si la actividad humana modifica la organización funcional de las comunidades. Entre 2005 y 2007 muestreamos 11 ríos durante dos períodos hidrológicos consecutivos, de alto y bajo caudal. Definimos diez rasgos biológicos a nivel de género, incluyendo aspectos de morfología (tamaño máximo, forma del cuerpo y flexibilidad, dureza del exoesqueleto), fisiología (déficit de tolerancia al oxígeno, tipo de la respiración y la forma de las branquias) y comportamiento (locomoción, hábitos alimentarios, adaptaciones específicas a las restricciones del flujo). El análisis RLQ permitió vincular las características del hábitat y los rasgos biológicos a través de una tabla de abundancia. La combinación de niveles altitudinales con los regímenes de flujo definen ?Habitat Templets? espacio-temporales. El tamaño del cuerpo, los hábitos alimentarios, la respiración y la tolerancia al déficit de oxígeno fueron los rasgos más asociados con el gradiente ambiental detectado. Los sitios de mayor altitud que muestran vegetación marginal, alta potencia y aguas bien oxigenadas presentan organismos filtradores, raspadores y depredadores, con respiración tegumentaria y baja tolerancia al déficit de oxígeno. Los sitios de menor altitud exhiben conductividad elevada, modificación del bosque de ribera, uso agrícola, escorrentía alta, transporte de sedimentos y concentración reducida de oxígeno. Estos sitios están caracterizados por organismos pequeños, colectores, con branquias y alta tolerancia al déficit de oxígeno. Estos resultados nos permiten proyectar un marco para monitorear cambios funcionales del sistema a través del grupo EPT.","palabras_clave":"EPT|ORGANIZACIÓN FUNCIONAL|YUNGAS|ANÁLISIS RLQ"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89141,"idioma_id":4,"titulo":"Towards a Dynamic Analysis of Weighted Networks in Biogeography","resumen":"An improvement to the Network Analysis Method (NAM) in Biogeography based on weighted inference and dynamic exploration of sympatry networks is proposed. Intricate distributions of species result in a reticulated structure of spatial associations. Species are geographically connected through sympatry links forming an overall natural network inbiogeography. Spatial records are the signals that provide evidence to infer these sympatry links in the network. Punctual data are independent of a priori area determination. NAM is oriented to detect groups of species embedded into the global network that are internally sustained by sympatric cohesiveness but weakly connected (or disconnected) to outgroup entities. These groups, called units of co-occurrence (UCs), are segregated through the iterative removal of intermediary species according to their betweenness scores. Instances of analysis of the original NAM are improved through the following changes and extensions: (i) inference of weighted sympatry networks using new measures sensitive to the strength ofoverlap and topological resemblance between set of points; (ii) construction of a basal network discriminating major from minor sympatry associations; (iii) evaluation of the entire process of iterative removal of intermediary species for the selection of UCs found on different subnetworks; (iv) network partitioning based on the intrinsic cohesiveness of the UCs; (v) production of a graphical tool (cleavogram) depicting the structural changes of the network along the removal process. Improvements are tested using real and hypothetical data sets. Resolution of patterns is notably increased due to a more accurate recognition of allopatric patterns and the possibility of segregating spatially overlapped UCs. As in original NAM, spatial expressions of UCs are building blocks for biogeography supported by strictly endemic and connected species through sympatry paths.&nbsp;","palabras_clave":"CLUSTER PATTERN RECOGNITION|COHESIVENESS|DOT MAPS|NAM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89142,"idioma_id":4,"titulo":"Melanin concentrating hormone (MCH) is involved in the regulation of growth hormone in Cichlasoma dimerus (Cichlidae, Teleostei)","resumen":"Growth hormone (GH) is the main pituitary hormone involved in somatic growth. In &#64257;sh, the neuroendocrine control of GH is multifactorial due to the interaction of multiple inhibitors and stimulators. Melanin-concentrating hormone (MCH) is a cyclic peptide involved in skin color regulation of &#64257;sh. In  addition, MCH has been related to the regulation of food intake in both mammals and &#64257;sh. There is only  one report presenting evidences on the GH release stimulation by MCH in mammals in experiments  in vitro, but there are no data on non-mammals. In the present work, we report for the &#64257;rst time the  sequence of MCH and GH cDNA in Cichlasoma dimerus, a freshwater South American cichlid &#64257;sh. We  detected contacts between MCH &#64257;bers and GH cells in the proximal pars distalis region of the pituitary  gland by double label confocal immuno&#64258;uorescence indicating a possible functional relationship. Besides,  we found that MCH increased GH transcript levels and stimulated GH release in pituitary cultures. Additionally, C. dimerus exposed to a white background had a greater number of MCH neurons with a larger  nuclear area and higher levels of MCH transcript than those &#64257;sh exposed to a black background. Furthermore, &#64257;sh reared for 3 months in a white background showed a greater body weight and total length  compared to those from black background suggesting that MCH might be related to somatic growth in  C. dimerus. Our results report for the &#64257;rst time, that MCH is involved in the regulation of the synthesis  and release of GH in vitro in C. dimerus, and probably in the &#64257;sh growth rate.","palabras_clave":"Melanin concentrating hormone|growth hormone|pituitary|teleosts"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89143,"idioma_id":4,"titulo":"A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determination","resumen":"Gonadal sex determination in vertebrates generally follows a sequence of genetically programmed events. In what is seemingly becoming a pattern, all con&#64257;rmed or current candidate \u201Cmaster\u201D sex-determining genes reported in this group, e.g., SRY in eutherian mammals, DMY\/dmrt1bY in medaka, DM-W in the African clawed frog, andDMRT1 in chicken encode transcription factors. In contrast, here we show that a male-speci&#64257;c, duplicated copy of the anti-Müllerian hormone (amh) is implicated in testicular development of the teleost &#64257;sh Patagonian pejerrey (Odontesthes hatcheri). The gene, termed amhy because it is found in a single metacentric\/submetacentric chromosome of XY individuals, is expressed much earlierthan the autosomal amh (6 d after fertilization vs. 12 wk after fertilization) and is localized to presumptive Sertoli cells of XY males during testicular differentiation.Moreover, amhy knockdown in XY embryos resulted in the up-regulation of foxl2 and cyp19a1a mRNAs and the development of ovaries. These results are evidence of a functional amh duplication in vertebrates and suggest that amhy may be the master sex-determining gene in this species. If con&#64257;rmed, this would be a unique instance of a hormone-related gene, a member of the TGF-&#946; superfamily, in such a role.","palabras_clave":"amh|sex determination|pejerrey"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89144,"idioma_id":4,"titulo":"Feminization and altered gonadal gene expression profile by ethynylestradiol exposure to pejerrey, Odontesthes bonariensis, a South American teleost fish","resumen":"In pejerrey, the ovarian differentiation has been associated with gonadal aromatase expression and it is also known that exposure of pejerrey larvae to estradiol (E2) produces all female populations. During the last years the presence of ethynylestradiol (EE2), an E2 analogue, has been reported in water reservoirs of different parts of the world. Here, the effects of EE2 were assessed on sex ratios and gene expression levels of gonadal aromatase (cyp19a1a), 11&#946;-hydroxysteroid deshydrogenase 2 (11&#946;hsd2), estrogens (er&#945;, er&#946;1) and androgens receptors (ar&#945;, ar&#946;). Pejerrey larvae were fed with commercial food containing EE2 (0.1 µg\/g and 1 µg\/g), and E2 (50 µg\/g) as a positive control for 6 weeks after hatching. The gonadal histological analysis showed that 42-46% of the fish had clearly differentiated ovaries both, in the EE2 and E2 treated groups, compared to 27 % in the control group. Moreover, in EE2 (1 µg\/g) and E2 treated groups, no fish presented signs of testicular development compared to controls. In addition, the expression of cyp19a1a and 11&#946;hsd2 were respectively significantly up- and down-regulated by EE2 and E2. Our results suggested that the feminization process driven by EE2 depends on the positive balance of cyp19a1a in relation to 11&#946;hsd2. These genes can then be used as early indicators of exposure to xenoestrogens in this species.","palabras_clave":"Endocrine Disruptors|Fish|Biomarkers|Ecotoxicology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89145,"idioma_id":4,"titulo":"The cortisol and androgen pathways cross-talk in high temperature-induced masculinization: the 11&#946;- hydroxysteroid dehydrogenase as a key enzyme","resumen":"          &nbsp;In many ectotherm species the  gonadal fate is modulated by temperature early in life  (Temperature-Dependent Sex Determination,  TSD) but the transducer mechanism between temperature and  gonadal differentiation is still elusive.  We  have recently shown that cortisol, the glucocorticoid stress-related  hormone in vertebrates, is involved in the TSD process of  pejerrey, Odontesthes  bonariensis. Particularly, all larvae  exposed to a male-producing temperature (MPT, 29°C) after hatching showed increased whole-body  cortisol and 11-ketotestosterone (11-KT, the main bioactive androgen in fish)  levels and developed as males. Moreover, cortisol administration  at an intermediate, mixed sex-producing temperature (MixPT, 24°C) caused increases in 11-KT  and in the frequency of males, suggesting a relation  between this glucocorticoid and androgens during  the masculinization process. In order to clarify the link between stress and  masculinization, the expression of hsd11b2, glucocorticoid receptors gr1 and gr2, and androgen receptors ar1 and ar2 was analyzed by RT-qPCR and in situ hybridization in larvae reared  at MPT, MixPT, and FPT (female-producing  temperature, 17°C) during the sex determination period. We also analyzed the effects  of cortisol treatment in larvae reared at MixPT and in adult  testicular explants incubated in vitro. MPT and cortisol treatment produced  significant increases in hsd11b2 mRNA expression. Also, gonadal  explants incubated in the presence of cortisol showed increases of 11-KT  levels in the medium. Taken together these  results suggest that cortisol promotes 11-KT production during high temperature-induced  masculinization by modulation of hsd11b2 expression and thus drives the  morphogenesis of the testes.  ","palabras_clave":"11&#946;-HSD|cortisol|11-ketotestosterone|glucocorticoid receptors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89146,"idioma_id":5,"titulo":"El litio y su relación con la Acuaporina-2 y el canal de sodio ENaC","resumen":"a","palabras_clave":"Lithium|Epithelial Sodium Channel|Aquaporin 2|Diabetes Insipida Nefrogénica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89147,"idioma_id":4,"titulo":"Angular and frequency dependence of standing spin waves in FePt films","resumen":"We present a detailed analysis of the dynamic response of the   magnetization in as-made FePt thin films, particularly studying the   angular dependence of standing spin waves that can be observed when the   external field is applied close to the film normal. We have found that   the field separation between the uniform and the first excited mode   depends strongly on angle and microwave frequency. To explain the   observed behavior we have adopted the surface inhomogeneity model in the   circular precession approximation. Using this model the experimental   data could be very well fitted assuming that spins are not totally   pinned at the surfaces by introducing a finite surface anisotropy. The   experimental angular behavior of the resonance field at three different   frequencies could be fitted with a single set of parameters indicating   that the reported changes in the surface anisotropy as a function of   film thickness are intrinsic to the samples.","palabras_clave":"IRON ALLOYS|magnetic anisotropy|magnetic thin films|magnetisation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89148,"idioma_id":4,"titulo":"Trypanosoma cruzi discrete typing units in Chagas disease patients from endemic and non endemic regions of Argentina","resumen":"Genetic diversity of Trypanosoma cruzi may play a role in pathogenesis of Chagas disease forms. Natural populations are classified into 6 Discrete Typing Units (DTUs) Tc I-VI with taxonomical status. This study aimed to identify T. cruzi DTUs in bloodstream and tissue samples of Argentinean patients with Chagas disease. PCR-based strategies allowed DTU identification in 256 clinical samples from 239 Argentinean patients. Tc V prevailed in blood from both asymptomatic and symptomatic cases and Tc I was more frequent in bloodstream, cardiac tissues and chagoma samples from immunosuppressed patients. Tc II and VI were identified in a minority of cases, while Tc III and Tc IV were not detected in the studied population. Interestingly, Tc I and Tc II\/VI sequences were amplified from the same skin biopsy slice from a kidney transplant patient suffering Chagas disease reactivation. Further data also revealed the occurrence of mixed DTU populations in the human chronic infection. In conclusion, our findings provide evidence of the complexity of the dynamics of T. cruzi diversity in the natural history of human Chagas disease and allege the pathogenic role of DTUs I, II, V and VI in the studied population.","palabras_clave":"Trypanosoma cruzi|DTUs|Chagas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89149,"idioma_id":4,"titulo":"Effects of Quaternary climatic changes on the phylogeography and historical demography of the subterranean rodent Ctenomys porteousi","resumen":"The contemporary distribution of organisms cannot be understood without knowing how species have responded to the geologic and climatic history of their environments. Genetic studies related to the demographic history of wildlife species can help us to elucidate the role of climate changes and other environmental forces in shaping patterns of distribution and population structure of the species. In this work we investigated the phylogeographic pattern and historical demography of the subterranean rodent Ctenomys porteousi. We examinedmitochondrial DNA control region sequences of 101 individuals collected from 7 localities that cover the complete distributional range of this species. Haplotype frequencies showed a significant population differentiation whereas the spatial distribution of haplotypes suggests moderate geographical structure. Genetic differentiation was not consistent with a simple model of isolation by distance and several independent estimates suggest that the observed phylogeographical pattern is the consequence of a complex demographic scenario. Our data suggest both reduction and population expansion events. Both kinds of demographic events were associated to major climatic changes that affected the study area during the Late Pleistocene and the Holocene. In particular, a relationship between historical changes in the degree of vegetation cover and population size for this rodent was inferred. We propose that the decrease in aridity of the Pampean region that started in the Pleistocene?Holocene boundary could have promoted a major decline in the effective population size of this species.                                                                                   ","palabras_clave":"phylogeography|historical demography| Ctenomys| climate change."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89150,"idioma_id":4,"titulo":"The impact of point source pollution on shallow groundwater used for human consump-tion in a threshold country","resumen":"Many developing and threshold countries rely on shallow groundwater wells for their water supplywhilst pit latrines are used for sanitation. We employed a unified strategy involving satellite images and environmental monitoring of 16 physico-chemical and microbiological water quality parameters to identify significant land uses that can lead to unacceptable deterioration of source water, in a region with a subtropical climate and seasonally restricted torrential rainfall in Northern Argentina.Agricultural and non-agricultural sources of nitrate were illustrated in satellite images and used toassess the organic load discharged. The estimated human organic load per year was 28.5 BOD5 tons and the N load was 7.5 tons, while for poultry farms it was 9940-BOD5 tons and 1037-N tons, respectively.Concentrations of nitrates and organics were significantly different between seasons in well water (pvalues of 0.026 and 0.039, respectively). The onset of the wet season had an extraordinarily negative impact on well water due in part to the high permeability of soils made up of fine gravels and coarse sand. Discriminant analysis showed that land uses had a pronounced seasonal influence on nitrates and introduced additional microbial contamination, causing nitrification and denitrification in shallow groundwater. P-well was highly impacted by a poultry farm while S-well was affected by anthropogenic pollution and background load, as revealed by Principal Component Analysis. The application of microbial source tracking techniques is recommended to corroborate local sources of human versus animal origin","palabras_clave":"POLLUTION|GROUNDWATER|HUMAN CONSUMPTION|THRESHOLD COUNTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89151,"idioma_id":4,"titulo":"ApoTransferrin: Dual Role on Adult Subventricular Zone-Derived Neurospheres","resumen":"Neural stem and progenitor cells (NSC\/NPCs) are multipotent self-renewing cells that are able to generate neurons,astrocytes and oligodendrocytes (OLs) within the adult central nervous system. We cultured NSC\/NPCs from the ratsubventricular zone as neurospheres (NS) and studied apoTransferrin (aTf) effects on oligodendroglial specification andmaturation. Our findings suggest that aTf acts at different stages during progression from NSC to mature oligodendrocytes.On the one hand, an early event associated with the activation of NSC\/NPCs proliferation and commitment toward theoligodendroglial fate, as indicated by increased BrdU incorporation, larger neurospheres production, and higher ability togenerate OL precursors (OPCs) from undifferentiated cultures. On the other hand, aTf exposure during differentiatingconditions favours OL maturation from OPCs by promoting OL morphological development. This evidence supports a keyrole of Tf on the generation of OL from NSC\/NPCs and highlights its potential in demyelinating disorder treatment.Citation: Silvestroff L, Franco PG, Pasquini JM (2012) ApoTransferrin: Dual Role on Adult Subventricular Zone-Derived Neurospheres. Silvestroff L, Franco PG, Pasquini JM (2012) ApoTransferrin: Dual Role on Adult Subventricular Zone-Derived Neurospheres. ","palabras_clave":"NEUROSPHERES|TRANSFERRIN|OLIGODENDROCYTES|STEM CELLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89152,"idioma_id":4,"titulo":"Direct interaction between EgFABP1, a fatty acid binding protein from Echinococcus granulosus, and membranes","resumen":"Background: Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requiresa high degree of lipid trafficking facilitated by lipid transporter proteins. Members of the fatty acid binding protein (FABP)family have been identified in Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requiresa high degree of lipid trafficking facilitated by lipid transporter proteins. Members of the fatty acid binding protein (FABP)family have been identified in Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requiresa high degree of lipid trafficking facilitated by lipid transporter proteins. Members of the fatty acid binding protein (FABP)family have been identified in Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling. This requiresa high degree of lipid trafficking facilitated by lipid transporter proteins. Members of the fatty acid binding protein (FABP)family have been identified in Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.Echinococcus granulosus, one of which, EgFABP1 is expressed at the tegumental level in the protoscoleces, but it has also been described in both hydatid cyst fluid and secretions of protoscoleces. In spite of aconsiderable amount of structural and biophysical information on the FABPs in general, their specific functions remainmysterious.Methodology\/Principal Findings: We have investigated the way in which EgFABP1 may interact with membranes using a variety of fluorescence-based techniques and artificial small unilamellar vesicles. We first found that bacterial recombinantEgFABP1 is loaded with fatty acids from the synthesising bacteria, and that fatty acid binding increases its resistance toproteinases, possibly due to subtle conformational changes induced on EgFABP1. By manipulating the composition of lipidvesicles and the ionic environment, we found that EgFABP1 interacts with membranes in a direct contact, collisional,manner to exchange ligand, involving both ionic and hydrophobic interactions. Moreover, we observed that the protein cancompete with cytochrome c for association with the surface of small unilamellar vesicles (SUVs).variety of fluorescence-based techniques and artificial small unilamellar vesicles. We first found that bacterial recombinantEgFABP1 is loaded with fatty acids from the synthesising bacteria, and that fatty acid binding increases its resistance toproteinases, possibly due to subtle conformational changes induced on EgFABP1. By manipulating the composition of lipidvesicles and the ionic environment, we found that EgFABP1 interacts with membranes in a direct contact, collisional,manner to exchange ligand, involving both ionic and hydrophobic interactions. Moreover, we observed that the protein cancompete with cytochrome c for association with the surface of small unilamellar vesicles (SUVs).variety of fluorescence-based techniques and artificial small unilamellar vesicles. We first found that bacterial recombinantEgFABP1 is loaded with fatty acids from the synthesising bacteria, and that fatty acid binding increases its resistance toproteinases, possibly due to subtle conformational changes induced on EgFABP1. By manipulating the composition of lipidvesicles and the ionic environment, we found that EgFABP1 interacts with membranes in a direct contact, collisional,manner to exchange ligand, involving both ionic and hydrophobic interactions. Moreover, we observed that the protein cancompete with cytochrome c for association with the surface of small unilamellar vesicles (SUVs).We have investigated the way in which EgFABP1 may interact with membranes using a variety of fluorescence-based techniques and artificial small unilamellar vesicles. We first found that bacterial recombinantEgFABP1 is loaded with fatty acids from the synthesising bacteria, and that fatty acid binding increases its resistance toproteinases, possibly due to subtle conformational changes induced on EgFABP1. By manipulating the composition of lipidvesicles and the ionic environment, we found that EgFABP1 interacts with membranes in a direct contact, collisional,manner to exchange ligand, involving both ionic and hydrophobic interactions. Moreover, we observed that the protein cancompete with cytochrome c for association with the surface of small unilamellar vesicles (SUVs).Conclusions\/Significance: This work constitutes a first approach to the understanding of protein-membrane interactions of EgFABP1. The results suggest that this protein may be actively involved in the exchange and transport of fatty acidsbetween different membranes and cellular compartments within the parasite.EgFABP1. The results suggest that this protein may be actively involved in the exchange and transport of fatty acidsbetween different membranes and cellular compartments within the parasite.EgFABP1. The results suggest that this protein may be actively involved in the exchange and transport of fatty acidsbetween different membranes and cellular compartments within the parasite.This work constitutes a first approach to the understanding of protein-membrane interactions of EgFABP1. The results suggest that this protein may be actively involved in the exchange and transport of fatty acidsbetween different membranes and cellular compartments within the parasite.","palabras_clave":"Echinococcus granulosus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89153,"idioma_id":4,"titulo":"Geophysical characterization of two circular structures at Bajada del Diablo (Patagonia, Argentina): Indication of impact origin","resumen":"AbstractAn impact origin has been proposed for the circular structures found in Bajada del Diablo, Patagonia, Argentina. Taking into account its extension and the number of impact structures, Bajada del Diablo would be the largest meteoritic impact areas known on Earth, being an extremely interesting area for the research of impact events and processes. Moreover, the global distribution of known impact structures shows a surprising asymmetry. Particularly, South America has only seven described areas. It is evident that this situation is an artifact, highlighting the importance of intensifying the research in the least studied areas such as Argentina. Circular structures in Bajada del Diablo have been identified on two rock types: the Quiñelaf eruptive complex and Pampa Sastre Formation. In the first case, circular structures are placed in olivine basalts. On the other hand, Pampa Sastre Formation (late Pliocene\/early Pleistocene) corresponds to conglomerate layers with basalt clasts boulder and block in size in a coarse sandy matrix. With the aim of further the investigation of the proposed impact origin for these circular structures, we carried out detailed topographic, magnetic and electromagnetic ground surveys in two circular structures (?8? and ?A?) found in Pampa Sastre conglomerates. Both circular structures are simple, bowl-shaped with rim diameters of 300 m and maximum depths of 10 m. They have been partially filled in by debris flows from the rims and wind-blown sands. Two preliminary magnetic profiles have also been carried out in circular structure ?G? found in Quiñelaf basalts. The magnetic anomalies show a circular pattern with a slightly negative and relatively flat signal in the circular structures? bases. Furthermore in the circular structures? rims, high-amplitude, conspicuous and localized (short wavelength) anomalies are observed. Such large amplitude and short wavelength anomalies are not detected outside the circular structures. For all used frequencies, the electromagnetic profiles show lower apparent electrical conductivities in the circular structures? base, while the rims present notably higher values. Curvature attributes, analytic signal, horizontal gradient and Euler solutions were calculated for the magnetic data. 2.5D magnetic models were developed across the studied circular structures. Our results suggest that in the circular structures? bases up to 12 m of Pampa Sastre conglomerate would have been removed. On the contrary, the circular structures? rims exhibit high-amplitude, localized magnetic anomalies and higher apparent electrical conductivities, which would be related to the anomalous accumulation of basalt boulders and blocks remanently magnetized. Such high-amplitude anomalies are not present outside the surveyed circular structures. The geomorphological, geological and geophysical features of the studied circular structures can only be explained by means of an extra-terrestrial projectile impact. We conclude that, considering the results obtained to date, Bajada del Diablo should be envisaged as a focus of further research, which could provide novel information about impact events, associated processes and their evidences. Particularly, the data produced in this study could represent one of the first documented geophysical signatures of the impact of a comet nucleus on Earth.","palabras_clave":"MAGNETOMETRY|CIRCULAR STRUCTURES|IMPACT CRATER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89154,"idioma_id":4,"titulo":"The Bajada del Diablo astrobleme-strewn field, central Patagonia Argentina: Extending the exploration to surrounding areas","resumen":"Ver archivo adjunto.","palabras_clave":"astrobleme-strewn field|magnetometry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89155,"idioma_id":4,"titulo":"Mayariochloa, a New Monotypic Genus Segregated from Scutachne (Poaceae, Panicoideae, Paniceae)","resumen":"The genus Scutachne (Poaceae, Paniceae) is revised. This American genus, which included two species from the Caribbean, wascircumscribed on the basis of morphological and molecular characters. To analyze both species of the genus, S. amphistemon and S. dura, adetailed study of the micromorphology of the upper anthecium and leaf anatomy, together with exomorphological characters, wasperformed. Both species differ in vegetative and reproductive characters, including blade distribution, ligules, presence of axillary inflorescences,consistency of upper glume, lower lemma, and lower palea, presence of a lower flower, upper anthecium ornamentation, andpresence of a rachilla extension. Anatomically, S. dura is a C4 PCK species, while S. amphistemon is a C3, non-Kranz taxon. The molecularphylogenetic analysis supports these morphological differences. As a result, we concluded that Scutachne, as presently circumscribed, is apolyphyletic genus. Therefore, the genus is here redefined and S. amphistemon is transferred to the new genus Mayariochloa. Affinities of thenew genus with other genera of Paniceae are also discussed.","palabras_clave":"Cuba|leaf anatomy|Melinidinae|phylogeny"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89156,"idioma_id":4,"titulo":"Two new shrubby species of the genus Staelia (Rubiaceae) from Serra do Curral Frio, Bahia, Brazil","resumen":"Two new shrubby species of Staelia (Rubiaceae) from northeastern Brazil are described and illustrated. Staelia glandulosa inhabits rocky fields on white sand areas,and differs from S. virgata in its shrubby habit, entirely glandular stipular bristles, large flowers, number of calyx lobes and large seeds. Staelia harleyi was found in the Cerrado biome on sandstone rocks at altitudes of 1000 m, recognizably different from S. virgata because the plant is shrubby, its calyx is a conspicuous tube, the calyx lobe is longer than the corolla tube, the corolla lobes are internally pilose, the ventral face of seeds has transversal furrows and the bracteole is sagittate at the apex. Electron microphotographs of the fruit and seed and images of both species in their habitats are provided.","palabras_clave":"S. glandulosa|S. harleyii|Curral Frio |Flora"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89157,"idioma_id":4,"titulo":"Non-O157:H7 Shiga Toxin Producing Escherichia coli in Bovine Rectums and Surface Water Streams on a Beef Cattle Farm in Argentina","resumen":"The purposes of this study were to detect non-O157 Shiga toxin producing Escherichia coli (STEC) in bovine rectums and water in a beef cattle farm in Argentina country-region, and to determine the pathogenic potential of the circulating strains. During the study, 292 rectal swabs from healthy animals and 79 environmental water samples were collected. The rectal swabs and one loop of the swabs, enriched in Escherichia coli broth for 24 h at 37_C, were streaked on MacConkey agar plates and incubated overnight at 37_C. The isolates were characterized by biochemical tests and serotyped. Nonmotile STEC strains were typed for their H-specific (fliC) antigens by polymerase chain reaction (PCR). Isolates were characterized by detection of stx1, stx2, and their variants, eae, ehxA, and saa genes. Macrorestriction fragment analysis by pulsed-field gel electrophoresis (PFGE) was performed using the PulseNet standardized protocol. From 371 samples analyzed, 36.6% of rectal swabs and 34.2% of water samples were non-O157 STEC-positive by PCR, and 110 strains from rectal swabs, but only three from water, were isolated. The strains were grouped into 24 different serotypes, from which, O103:[H2] (n = 12), O136:H12 (n = 8), O178:H19 (n = 8), and O103:NM (n = 5) were most prevalent, representing 29.2% of the isolates. Predominant genotypes were stx1\/eae\/ehxA (16.8%) and stx2\/saa\/ehxA (15.9%). PFGE analysis revealed 56 different patterns, with 65 strains grouped in 19 clusters of 100% similarity. Two STEC O124:H19 strains isolated from rectal swabs and water with a 5-month interval harbored the stx1\/stx2\/saa\/ehxA genotype, and showed an indistinguishable PFGE profile. By comparison, some XbaI-PFGE patterns identified in the present study were identical to the profiles of strains isolated from human, food, and animal sources included in the Argentine PulseNet database. By PCR, similar non-O157 detection rates were found in rectal swabs and water. However, the methodology for water samples needs to be improved, since only three strains from the total number of positive samples were recovered","palabras_clave":"non-O157 Shiga toxin-producing Escherichia coli (STEC)|bovine rectums | water |polymerase chain reaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89158,"idioma_id":4,"titulo":"Patterns of skull development in anurans: size and shape relationship during postmetamorphic cranial ontogeny in five species of the Leptodactylus fuscus Group (Anura, Leptodactylidae)","resumen":"The effect of allometric ontogenetic changes onmorphology has been examined primarily in larval stagesof anurans. To our knowledge, such studies after metamorphosisare non-existent, and this information isimportant because the skull acquires its adult configurationin that period. Using geometric morphometrics, we studiedpostmetamorphic shape changes in the skull of five speciesof the Leptodactylus fuscus Group (Leptodactylus bufonius,Leptodactylus elenae, Leptodactylus fuscus, Leptodactyluslatinasus, and Leptodactylus mystaceus), a group of smalltomedium-sized frogs. Size change is an important factorin explaining shape change during postmetamorphicgrowth in four of these species; ontogenetic trajectorieshave in general parallel directions and similar rates ofshape change. L. latinasus skulls tend to differ in size andshape from the others, and the allometric model, althoughsignificant, explains low percentages of shape change. Thediverging slope of its ontogenetic trajectory indicates nonheterochronic,allometric repatterning change regarding theontogenies of L. bufonius, L. elenae, and L. fuscus. Conversely,ontogenetic scaling appears as the main mechanismmodeling shape change as regard to L. mystaceus;hence, we suggest that a process of progenesis determinesthe small, juvenile-like cranium of L. latinasus. The disparity analysis shows a broader morphological divergencein metamorph morphospace than in adults, suggestingthat postmetamorphic stages can contribute withinformative characters to phylogenetic analysis. Differencesin shapes between metamorphs and adults indicatethat many changes occur after metamorphosis, but whetherthese changes result from internal or ecological requirementsat different stages remains unknown.","palabras_clave":"Allometry|Geometric Morphometrics|Ontogenetic Trajectories"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89159,"idioma_id":4,"titulo":"M-estimators for Isotonic Regression","resumen":"In this paper we propose a family of robust estimates for isotonic regression: isotonic M-estimators. We show that their asymptotic distribution is, up to an scalar factor, the same as that of Brunk\u2019s classical isotonic estimator. We also derive the influence function and the breakdown point of these estimates. Finally we perform a Monte Carlo study that shows that the proposed family includes estimators that are simultaneously highly efficient under Gaussian errors and highly robust when the error distribution has heavy tails.","palabras_clave":"Isotonic regression|Robust estimators|M-estimators"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89160,"idioma_id":4,"titulo":"Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast","resumen":"The apicoplast is a highly specialized organelle that mediates required functions in the growth and replication of apicomplexan parasites. Despite structural conservation of the apicoplast among different parasite genera and species, there are also critical differences in the metabolic requirements of different parasites and at different stages of the life cycle. To specifically compare apicoplast pathways between parasites that have both common and unique stages, we characterized the apicoplast in Babesia bovis, which has only intraerythrocytic asexual stages in the mammalian host, and compared it to that of Plasmodium falciparum, which has both asexual intraerythrocytic and hepatic stages. Specifically focusing on the type II fatty acid (FASII) and isoprenoid (MEP) biosynthesis pathways, we searched for pathway components and retention of active sites within the genome, localized key components [acyl carrier protein (ACP) and 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB)] to the apicoplast, and demonstrated that the N-terminal bipartite signals of both proteins are required and sufficient for trafficking to the apicoplast lumen. Using specific pharmacologic inhibition, we demonstrated that MEP biosynthesis may be disrupted and its presence is required for intraerythrocytic growth of B. bovis asexual stages, consistent with the genomic pathway analysis and with its requirement in the asexual erythrocytic stages of P. falciparum. In contrast, FASII biosynthesis may or may not be present and specific drug targets did not have any inhibitory effect to B. bovis intraerythrocytic growth, which is consistent with the lack of requirement for P. falciparum intraerythrocytic growth. However, genomic analysis revealed the loss of FASII pathway components in B. bovis whereas the pathway is intact for P. falciparum but regulated to be expressed when needed (hepatic stages) and silent when not (intraerythrocytic stages). The results indicate specialized molding of apicoplast biosynthetic pathways to meet the requirements of individual apicomplexan parasites and their unique intracellular niches.","palabras_clave":"Apicmplexan|apicoplast|babesia bovis|Plasmodim falciparum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89161,"idioma_id":5,"titulo":"Relación con el saber y recursos matemáticos de adultos que inician la escolaridad primaria","resumen":"En este artículo se presentan algunos resultados de un estudio de casos realizado en la Ciudad de Buenos Aires dirigido a conocer la relación con el saber matemático de alumnos adultos que recién inician o reinician su escolaridad primaria y sus conocimientos sobre la numeración y las operaciones. Un marco teórico en el que se apoyó este estudio ha sido la Relación con el Saber de Charlot (1991). También se han tomado los aportes de la Didáctica de la Matemática francesa, en particular de las teorías de  Brousseau (1986) y Vergnaud (1990).  Entre los principales hallazgos encontramos que las razones que llevan a los alumnos adultos a ir a la escuela y a estudiar matemáticas no refieren exclusivamente a un sentido utilitario. Por el contrario, la escuela es vivida como un lugar de profunda transformación personal.  Relevamos una gran disponibilidad de conocimientos aritméticos. Por ejemplo, leen y escriben números de varias cifras, resuelven problemas que involucran la posicionalidad del sistema de numeración y disponen de variadas estrategias de cálculo mental.  Los resultados obtenidos permiten discutir perspectivas didácticas vigentes en la enseñanza de la matemática a adultos y constituyen puntos de partida para el diseño y estudio de situaciones de enseñanza.","palabras_clave":"MATEMÁTICA|ADULTOS|PRIMARIA|RELACIÓN CON EL SABER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89162,"idioma_id":4,"titulo":"Atorvastatin improves sodium handling and decreases blood pressure in salt loaded rats with chronic renal insufficiency","resumen":"Objective: Oxidative stress and inflammation seem to mediate the cardiovascular risks associated  with salt sensitivity. Because hydroxymethyl glutaryl coenzyme A reductase inhibitors decrease  oxidation and increase nitric oxide (NO) synthesis, we examined the effects of atorvastatin (ator)  on tissue injury in rats with a reduced renal mass produced by 5\/6 nephrectomy. This salt-sensitive  hypertension model causes kidney and cardiovascular injuries.  Methods: After undergoing 5\/6 nephrectomy or sham surgery, male Sprague\u2013Dawley rats were  randomized into five groups: sham, reduced renal mass and a normal salt diet (NNaD), NNaDþator  (50 mg $ kg1 $ d1), reduced renal mass and a high salt diet (HNaD), and HNaDþator. After  assessing the sodium balance for 7 d, we measured blood pressure (BP), creatinemia, proteinuria,  nitrites, and 12(S)-hydroxy 5,8,10-heptadecatrienoic acid, the renal cortical expression of endothelial  NO synthase, and the ratio of left ventricular weight to body weight.  Results: In NNaD rats, creatinine, proteinuria, and 12(S)-hydroxy 5,8,10-heptadecatrienoic acid  increased, renal NO indices decreased, but the Naþ balance, BP, and the left ventricular weight\/  body weight ratio remained unchanged. In the NNaD group, atorvastatin normalized the  NO indices and decreased BP and proteinuria, although the remaining parameters continued  unchanged. In contrast, HNaD increased creatinemia, proteinuria, and 12(S)-hydroxy  5,8,10-heptadecatrienoic acid excretion rates and decreased renal endothelial NO synthase. Salt  retention was accompanied increased BP and ventricular weight. In this HNaD group, atorvastatin  prevented a BP increase, partly decreased sodium retention, but failed to improve NO indices,  proteinuria, oxidant stress, and the left ventricular weight\/body weight ratio.  Conclusion: Atorvastatin exerts beneficial effects on renal function, injury, and salt sensitivity in  rats with a reduced renal mass on an NNaD. The HNaD hampers these beneficial effects.","palabras_clave":"Renal failure|Salt sensitivity|Sodium balance|Nitric Oxide"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89163,"idioma_id":4,"titulo":"Nothofagus dombeyi regeneration in declining Austrocedrus chilensis forests: effects of overstory mortality and climatic events","resumen":"This research examines the regeneration dynamics of Nothofagus dombeyi and Austrocedrus chilensis in A. chilensis-dominated forests growing near the eastern limit of N. dombeyi where precipitation is limiting. In these forests the widespread decline and mortality of overstory A. chilensis trees, known as ´mal del ciprés´ (cypress sickness), generates large canopy gaps in which new individuals establish. Our objective was to study the population dynamics of N. dombeyi and A. chilensis in these forests to investigate the influences of verstory tree death and climatic variation on establishment. We sampled 6 symptomatic A. chilensis stands and used dendrochronological techniques to reconstruct basal area development and regeneration establishment over time. Bivariate event analysis was performed to examine the temporal relationships between tree establishment and mortality events and climatic variation. Overstory A. chilensis trees established as post-fire cohorts, with subsequent establishment of A. chilensis and N. dombeyi during the past 50-60 years. Regeneration in the past two decades was primarily N. dombeyi. The establishment of both A. chilensis and N. dombeyi was synchronous with overstory tree mortality events, but it was more consistent among stands and prolonged for N. dombeyi. Establishment of A. chilensis was not associated with climatic events but N. dombeyi establishment was synchronous with droughts, possibly related to climate-driven mortality creating canopy gaps or reducing competition within gaps. We have demonstrated that N. dombeyi has the ability to establish in post-fire A. chilensis-dominated forests resulting in mixed-species, uneven-aged forests. The ongoing increase in the abundance of N. dombeyi relative to A. chilensis represents a shift in composition and increased complexity in stand structure driven by ´mal del ciprés´ and climatic variation.","palabras_clave":"Regeneration|Tree death|Climate|Stand dynamics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89164,"idioma_id":4,"titulo":"Frost ring distribution in Araucaria araucana trees from the xeric forests of Patagonia, Argentina","resumen":"Frost rings are defined as anatomically abnormal and ecophysiologically pathological structures. We studied the frost injuries in treerings of Araucaria araucana trees growing at the northern limit of its natural distribution. We recorded 121 frost injuries at two sites in the northern xeric distribution of A. Araucana forests.Frost rings at both sites were primarily restricted to the middle frost ring section of the rings. These results represent the first attempt to report and describe the occurrence of these events for this species and region. These proxy records represent important indicators of extreme temperature conditions.","palabras_clave":"tree-rings|injuries|earlywood|latewood|extreme events"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89165,"idioma_id":4,"titulo":"Apple snails and their endosymbionts bioconcentrate heavy metals and uranium from contaminated drinking water","resumen":"Purpose The differential ability of apple snail tissues, endosymbionts,  and eggs to bioaccumulate several metals (Sb,As, Ba, Br, Zn, Cr, Fe, Hg, Se, and U) was investigated.Methods Metal concentrations were determined by neutron activation analysis in several tissues, endosymbionts, and eggs from mature apple snails cultured in either drinking water or reconstituted water (prepared with American Society for Testing and Materials type I water).","palabras_clave":"sentinel organism|symbiosis|Cyanobacteria|water pollution"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89166,"idioma_id":4,"titulo":"-Cultivable microbiota of Lithobates catesbeianus and advances in the selection of lactic acid bacteria as biological control agents in raniculture.","resumen":"The cultivable microbiota of skin and cloaca of captive Lithobates catesbeianus includes microorganisms generally accepted as beneficial and potentially pathogenic bacteria. In order to select a group of potentially probiotic bacteria, 136 isolates were evaluated for their surface properties and production of antagonistic metabolites. Then, 11 lactic acid bacteria (LAB) strains were selected and identified as Lactobacillusplantarum, Lb. brevis, Pediococcus pentosaceus, Lactococcus lactis, L. garvieae and Enterococcus gallinarum. Studies of compatibility indicate that all the strains could be included in a multi-strain probiotic, withthe exception of Ent. gallinarum CRL 1826 which inhibited LAB species through a bacteriocin-like metabolite. These results contribute to the design of a probiotic product to improve the sanitary status of bullfrogsin intensive culture systems, to avoid the use of antibiotics and thus to reduce production costs. Itcould also be an alternative to prevent infectious diseases during the ex situ breeding of amphibian species under threat of extinction.Lithobates catesbeianus includes microorganisms generally accepted as beneficial and potentially pathogenic bacteria. In order to select a group of potentiallyprobiotic bacteria, 136 isolates were evaluated for their surface properties and production of antagonisticmetabolites. Then, 11 lactic acid bacteria (LAB) strains were selected and identified as Lactobacillus plantarum, Lb. brevis, Pediococcus pentosaceus, Lactococcus lactis, L. garvieae and Enterococcus gallinarum. Studies of compatibility indicate that all the strains could be included in a multi-strain probiotic, with the exception of Ent. gallinarum CRL 1826 which inhibited LAB species through a bacteriocin-like metabolite. These results contribute to the design of a probiotic product to improve the sanitary status of bullfrogs in intensive culture systems, to avoid the use of antibiotics and thus to reduce production costs. It could also be an alternative to prevent infectious diseases during the ex situ breeding of amphibian species under threat of extinction. Lithobates catesbeianus includes microorganisms generally accepted as beneficial and potentially pathogenic bacteria. In order to select a group of potentiallyprobiotic bacteria, 136 isolates were evaluated for their surface properties and production of antagonisticmetabolites. Then, 11 lactic acid bacteria (LAB) strains were selected and identified as Lactobacillus plantarum, Lb. brevis, Pediococcus pentosaceus, Lactococcus lactis, L. garvieae and Enterococcus gallinarum. Studies of compatibility indicate that all the strains could be included in a multi-strain probiotic, with the exception of Ent. gallinarum CRL 1826 which inhibited LAB species through a bacteriocin-like metabolite. These results contribute to the design of a probiotic product to improve the sanitary status of bullfrogs in intensive culture systems, to avoid the use of antibiotics and thus to reduce production costs. It could also be an alternative to prevent infectious diseases during the ex situ breeding of amphibian species under threat of extinction. Lithobates catesbeianus includes microorganisms generally accepted as beneficial and potentially pathogenic bacteria. In order to select a group of potentiallyprobiotic bacteria, 136 isolates were evaluated for their surface properties and production of antagonisticmetabolites. Then, 11 lactic acid bacteria (LAB) strains were selected and identified as Lactobacillus plantarum, Lb. brevis, Pediococcus pentosaceus, Lactococcus lactis, L. garvieae and Enterococcus gallinarum. Studies of compatibility indicate that all the strains could be included in a multi-strain probiotic, with the exception of Ent. gallinarum CRL 1826 which inhibited LAB species through a bacteriocin-like metabolite. These results contribute to the design of a probiotic product to improve the sanitary status of bullfrogs in intensive culture systems, to avoid the use of antibiotics and thus to reduce production costs. It could also be an alternative to prevent infectious diseases during the ex situ breeding of amphibian species under threat of extinction.","palabras_clave":"L. catesbeianus Raniculture |Red-leg syndrome|Lactic acid bacteria| Probiotics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89167,"idioma_id":4,"titulo":"Nature of inclined growth in thin-layer electrodeposition under uniform magnetic fields","resumen":"Electrochemical deposition (ECD) in thin cells in a vertical position relative to gravity, subject to an externaluniform magnetic field, yields a growth pattern formation with dense branched morphology with branches tiltedin the direction of the magnetic force. We study the nature of the inclined growth through experiments andtheory. Experiments in ECD, in the absence of magnetic forces, reveal that a branch grows by allowing fluid topenetrate its tip and to be ejected from the sides through a pair of symmetric vortices attached to the tip. Theupper vortices zone defines an arch separating an inner zone ion depleted and an outer zone in a funnel-likeform with a concentrated solution through which metal ions are carried into the tip. When a magnetic field isturned on, vortex symmetry is broken, one vortex becoming weaker than the other, inducing an inclination ofthe funnel. Consequently, particles entering the funnel give rise to branch growth tilted in the same direction.Theory predicts, in the absence of a magnetic force, funnel symmetry induced through symmetric vortices drivenby electric and gravitational forces; when the magnetic force is on, it is composed with the pair of clockwiseand counterclockwise vortices, reducing or amplifying one or the other. In turn, funnel tilting modifies particletrajectories, thus, growth orientation.","palabras_clave":"ELECTROCHEMICAL DEPOSITION|MAGNETIC FIELD|IONIC TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89168,"idioma_id":5,"titulo":"AMENAZAS DE DEPÓSITOS DE LADERAS EN AMBIENTES ÁRIDOS. LA REVEGETACIÓN COMO ACCIÓN PREVENTIVA (BROMELIACEAE - DEUTEROCOHNIA LONGIPETALA (BAKER) MEZ.)","resumen":"En la región central de la vertiente occidental de la Precordillera Oriental, se efectuó un estudio del subsistema físico y del biótico, para reconocer amenazas potenciales de lóbulos o depósitos de abanicos aluviales y su probable atenuación mediante la propagación de vegetación nativa existente. El análisis geomorfológico presenta numerosos depósitos con distintos tipos de dinámicas y en diferentes posiciones topográficas, correspondientes a ciclos sedimentarios acontecidos durante el Cenozoico tardío. La vegetación relevada muestra especies y coberturas vegetales diferentes en los depósitos fanglomerádicos, destacándose el predominio de Deuterocohnia longipetala (Baker) Mez.). Los depósitos actuales y activos tienen un predominio de Bulnesia retama y Larrea divaricata mientras que los inactivos tienen un dominio de chaguares (Deuterocohnia longipetala). Se recomienda la propagación y revegetación de los lóbulos semiactivos con esta planta dada su alta resistencia a las condiciones xéricas y  buena capacidad de fijación y formación de suelos.","palabras_clave":"Aluviones|Piedemontes |mitigacion |revegetacion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89169,"idioma_id":4,"titulo":"A new proterochampsid Chanaresuchus ischigualastensis (Diapsida, Archosauriformes) in the Early Late Triassic Ischigualasto Formation, Argentina","resumen":"The proterochampsids are a group of crocodile-like archosauriforms usually considered as one of the potential successive sister-taxa of the crown-group Archosauria (e.g., Sereno and Arcucci, 1990; Sereno, 1991; Dilkes and Sues, 2009; Ezcurra et al., 2010). The clade is currently endemic for the late Middle to the early Late Triassic of South America. The best known proterochampsids come from the Chañares and Ischigualasto formations, which belong to the Ischigualasto-Villa Unión Basin (Fig. 1), formed during the breakup of Gondwana (Uliana and Biddle, 1988; Ramos and Kay, 1991). The tetrapod assemblage from the Chañares Formation (Anisian-early Carnian; Desojo et al., 2011) has been usually interpreted to differ from that of the Ischigualasto Formation (late Carnian-earliest Norian; Martínez et al., 2011), and this traditional view also applies for proterochampsids. In the Chañares Formation the proterochampsid genera Chanaresuchus, Gualosuchus, and Tropidosuchus (Romer, 1971, 1972; Arcucci, 1990) were documented, whereas in the Ischigualasto Formation only the genus Proterochampsa was reported (Reig, 1959). The latter highlighted a complete replacement at a generic level among these proterochampsid assemblages in southwestern Pangea. However, an almost complete proterochampsid skeleton from the Late Triassic Ischigualasto Formation is preliminarily described here and assigned to the traditional Middle Triassic genus Chanaresuchus (cf. Sill et al., 1994). Accordingly, the new proterochampsid record reported here changes the pattern of macroevolutionary history of the group during the Middle to Late Triassic southwestern in Pangea.","palabras_clave":"Triassic|Ischigualasto|Proterochampsidae|Carnian"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89170,"idioma_id":4,"titulo":"Paleolimnology evolution in rift basins: the Ischigualasto-Villa Unión Basin (Central-Western Argentina) during the Triassic","resumen":"Extensional basins offer a high preservation potential for sedimentary and fossil records. Nonmarine rift basins contain diverse environments, including fluvial and lacustrine. Lake deposits have long been recognized as significant archives of the paleoenvironmental record. The Ischigualasto-Villa Unión Basin represents the only nearly continuous continental Triassic record with up to 6000 m of alluvial, fluvial, and lacustrine deposits. The deep lacustrine interval is known as the Los Rastros Formation that consists of several lacustrine-deltaic cycles. A detailed facies analysis allowed the characterization of five facies associations and two types of cycles: (1) a shoreline-dominated, progradational Type I cycle containing Facies association A (offshore lacustrine deposits) and Facies association B (marginal palustrine deposits along the shoreline of the lake) or Facies association C (lacustrine siliciclastic coastal deposits) and (2) a deltaic-dominated, progradational Type II cycle characterized by Facies association A (offshore lacustrine and prodelta deposits), Facies association D (delta front deposits), and Facies association E (deltaic plain deposits). The sedimentary evolution of the Chañares-Los Rastros sequence is defined within this extensional setting as one depositional sequence with three system tracts (lowstand, transgressive, and highstand system tract). Biotic, abiotic, and sedimentologic data allowed the interpretation of the limnologic dynamics of the Los Rastros paleolake as a deep freshwater lake within a half-graben, exhibiting meromixis, and showing a change from moderate eutrophic conditions with low oxygen content to relatively oxygenated oligotrophic conditions.. Thus, the successive fluctuations recorded in lake level are considered, in the sequence stratigraphy framework of Bohacs et al., to reflect the relative balance of sediment and water input versus potential for accommodation in an overfilled lacustrine basin.","palabras_clave":"Los Rastros Formation|Western Gondwana|Limnogeology|Rift Basin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89171,"idioma_id":4,"titulo":"First occurrence of charophyte algae from a Triassic Paleolake in Argentina and their 2 paleoenvironmental context","resumen":"This paper presents the first record of charophytes from the Triassic sedimentary rocks of Argentina and the entire southern hemisphere. Algal remains were found in the Cerro Puntudo Formation dated as Anisian  (243.8±1.9 Ma). The formation is part of the Cuyana Basin, which formed as consequence of the Triassic rifting of Pangaea. The paleoenvironments represented by this succession include from bottom to top: (1) a  proximal to medial alluvial fan system; (2) a distal alluvial fan deposit; (3) a braided fluvial system with small channelized bodies; (4) a distal fluvial system containing rare carbonates; and (5) a carbonate-rich lacustrine system. The lacustrine facies association corresponds mainly to carbonate microbialites with three recognized facies, namely disrupted micritic limestones (Lmd), stromatolitic limestones (Ls), and oncolitic limestones (Lo). The Lo facies is rich in oncolites formed by filamentous algae in the cortex and charophyte remains (gyrogonites) in the nucleus and is interpreted as being deposited in a carbonate-rich pond environment,perhaps sourced from springs. Filamentous algae are thought to cause the precipitation of carbonates and trigger the development of micritic coatings in the ponds. Sedimentary and paleobiologic evidence suggest minor movement of the oncolites in a ponded environment where charophytes developed. The charophyte remains found in the Cerro Puntudo Formation are gyrogonites attributed to the Porocharaceae family. All the previous records for Triassic Charophyta correspond to Laurasia in the northern hemisphere, therefore, the paleolatitudinal location of this finding allows the expansion of the paleobiogeographic distribution of the group into Gondwana.","palabras_clave":"Carbonate lake|Freshwater algae|Gondwana|Gyrogonites|Rift basin|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89172,"idioma_id":4,"titulo":"Large-Diameter Burrows of the Triassic Ischigualasto Basin, NW Argentina: Paleoecological and Paleoenvironmental Implications","resumen":"Large-diameter ichnofossils comprising three morphotypes have been identified in the Upper Triassic Ischigualasto and Los Colorados formations of northwestern Argentina. These burrows add to the global record of the early appearance of fossorial behavior during early Mesozoic time. Morphotypes 1 and 2 are characterized by a network of tunnels and shafts that can be assigned to tetrapod burrows given similarities with previously described forms. However, differences in diameter, overall morphology, and stratigraphic occurrence allow their independent classification. Morphotype 3 forms a complex network of straight branches that intersect at oblique angles. Their calcareous composition and surface morphology indicate these structures have a composite biogenic origin likely developed due to combined plant\/animal interactions. The association of Morphotypes 1 and 2 with fluvial overbank lithologies deposited under an extremely seasonal arid climate confirms interpretations that the early appearance of burrowing behavior was employed by vertebrates in response to both temperature and moisture-stress associated with seasonally or perpetually dry Pangean paleoclimates. Comparisons of burrow morphology and biomechanical attributes of the abundant paleovertebrate fauna preserved in both formations permit interpretations regarding the possible burrow architects for Morphotypes 1 and 2. In the case of the Morphotype 1, the burrow constructor could be one of the small carnivorous cynodonts, Ecteninion or Probelesodon. Assigning an architect for Morphotype 2 is more problematic due to mismatches between the observed burrow morphology and the size of the known Los Colorados vertebrates.","palabras_clave":"Burrows|Ischigualasto|Paleoecological|Paleoenvironmental"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89173,"idioma_id":4,"titulo":"Oil quality of maize and soybean genotypes with increased oleic acid percentage as affected by intercepted solar radiation and temperature","resumen":"Oil fatty acid composition of traditional genotypes of several crops including maize and soybean is affected by intercepted solar radiation per plant and temperature during grain filling. The effect of intercepted radiation on oil fatty acid composition of genotypes with increased oleic acid percentage of maize and soybean is unknown. Likewise, on such kind of maize genotypes, no studies have been performed about the effect of temperature on the oleic acid percentage. The objective of this work was to investigate and model the effect of intercepted solar radiation per plant and daily mean temperature during grain filling on the oleic acid percentage in the oil of maize and soybean genotypes with increased oleic acid grown under non limiting conditions. Field experiments were conducted in Balcarce and Cordoba in two growing seasons. An experiment with maize genotypes was also conducted in two sowing dates in Pergamino. The effect of intercepted solar radiation during grain filling on oil fatty acid composition was studied by shading and thinning plants. To evaluate the effect of daily mean temperature, plants were exposed to different temperatures during grain filling in two experiments performed in greenhouse and growth chambers. At harvest oil fatty acid composition was determined by gas-liquid chromatography. Intercepted solar radiation per plant or temperature increased the oleic acid percentage between 9 and 30 percentage points depending on the species and genotype. In both species, genotypes with increased oleic acid percentage presented a higher sensitivity of oleic acid percentage to variations in intercepted solar radiation than traditional ones. The effect of temperature on oil fatty acid composition was also higher in maize genotypes with increased oleic acid percentage than in the traditional one of the same species. In soybean, the sensitivity of oleic acid percentage to temperature was higher in one genotype and lower in the other as compared to the traditional one. Oleic acid percentage was linearly related to DMT but curvilinearly related to ISR per plant, reaching a maximum concentration of this fatty acid at high levels of irradiance. For both species, models that consider the additive effects of intercepted solar radiation and temperature were established. Predictions of the models were validated with data from six field independent experiments. The models adequately estimated (r2>sup 0.65) the oleic acid percentage of these genotypes grown under different temperatures and ISR per plant during grain filling from these experiments. These results could help to identify crop management practices (e.g. sowing dates, locations, sowing density), in the view to obtain a given oil quality when growing maize and soybean with increased oleic acid percentage.","palabras_clave":"OIL|OLEIC ACID|INTERCEPTED SOLAR RADIATION|TEMPERATURE SENSITIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89174,"idioma_id":4,"titulo":"Oil yield components and oil quality of high stearic-high oleic sunflower genotypes as affected by intercepted solar radiation during grain filling","resumen":"High stearic-high oleic sunflower oil presents high thermal stability. This oil is an alternative to the hydrogenation process which produces trans fatty acids. The effect of intercepted solar radiation (ISR) per plant during grain filling on oil yield components and oil fatty acid composition was investigated in three sunflower high stearic-high oleic genotypes. Three field experiments were conducted and treatments to modify ISR per plant were applied during grain filling: shading, defoliating and thinning plants. Increasing ISR per plant linearly increased grain number per capitulum, weight per grain and in some cases palmitic and stearic acid percentages. In the hybrid, grain oil percentage and oleic acid concentration increased with a decreasing rate, reaching a maximum value at high levels of ISR per plant. Linoleic acid percentage decreased with a decreasing rate, reaching a minimum value at high levels of ISR per plant. Oil yield components presented heterosis. This information contributes to explain the effects of environment on yield and oil quality in high stearic-high oleic genotypes and could be used to design management practices that optimize these traits. ","palabras_clave":"FATTY ACID COMPOSITION|LINOLEIC ACID|STEARIC ACID|HETEROSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89175,"idioma_id":4,"titulo":"A model driven development approach based on a reference model for predicting disruptive events in a supply process","resumen":"Due to the impossibility of predicting with certainty the occurrence of disruptive events, buffers defined to obtain a robust schedule could not absorb all the changes. Then, local modifications of the schedule are usually performed to avoid a new planning task. For this task, obtaining disruptive event information in advance can help to make better decisions. As a result, ability to predict disruptive events that affect the execution of the supply process an order represents is required. With the objective of satisfying this requirement, this work proposes a model driven development approach based on a reference model to automate the generation of the monitoring model of a supply process able to anticipate the occurrence of a disruptive event by monitoring variables that can explain it.","palabras_clave":"SCEM SYSTEMS|DISRUPTIVE EVENTS|EVENT MANAGEMENT|MONITORING SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89176,"idioma_id":4,"titulo":"Logistic models for estimating epidemic increase rates of blueberry foliar diseases based on meteorological and leaf senescence variables","resumen":"Alternaria tenuissima is one of the most important pathogens on blueberry  (Vaccinium corymbossum) in Argentina, causing leaf spots, twig blight and fruit rot. The severity of leaf spots caused by A. tenuissima was estimated in crops located in San Pedro, Gualeguaychú and Concordia (Argentina), during spring and summer 2008 and 2009. Each linearised disease progress curve (3-4 observations per crop cycle) adjusted to Logistic and Gompertz epidemiological models (R2  > 0.77 to 0.98) for Concordia and San Pedro. Every 14 days, epidemic daily increase rate (DI) was estimated from disease epidemic curves. DI values were binary categorized according to median values (DI= 0.04253) for the 36 severity percentages estimated every 14 days, into severe (DI&#8805; 0.04253), and slight to null (DI 0.55). The best logistic regression model of binary response, that integrated LS, RF and the interaction MMT*RF, showed a prediction accuracy of 97%. Among ordinal response models, the bivariate one that integrated LS factor and the interaction MMT*RF was chosen (92% prediction accuracy). These results add information for the development of a predictive system for blueberry leaf diseases, in a context of sustainable crop health management.","palabras_clave":"Vaccinium corymbossum|Alternaria tenuissima|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89177,"idioma_id":4,"titulo":"The Development of Dermatonotus muelleri (Anura: Microhylidae: Gastrophryninae)","resumen":"The monophyly of Microhylidae is supported by an overwhelming accumulation of synapomorphic larval features. Despite the distinctiveness of the microhylid tadpole, few studies have focused on larval development. Microhylid larval morphology is usually described and based on standard tables that imply that developmental events at equivalent stages of overall tadpole development are independent from species-specific patterns of developmental timing. Herein, we present additional developmental data based on external morphology and field data on larval growth for the gastrophrynine microhylid Dermatonotus mueller&lt;bold&gt;i. We describe internal morphological variation (e.g., skeletal and soft systems) during larval development. The results indicate that the onset of some metamorphic changes occur earlier than those implied in current anuran developmental tables. This study provides baseline information for microhylid species that will allow comparisons of ontogenetic trajectories, heterochronic patterns influencing larval body plan, and the role of larval morphology on the adult microhylid body plan.","palabras_clave":"Anura|tadpole|heterchrony|development"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89178,"idioma_id":4,"titulo":"Ontogenetic and structural variation of mineralizations and ossifications in the Integument within ceratophryid frogs (Anura, Ceratophryidae)","resumen":"ver pdf","palabras_clave":"calcified layer|dorsal shield|Ceratophrys|Lepidobatrachus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89179,"idioma_id":4,"titulo":"Arginase-dependent suppression by CpG-ODN plus IFA-induced splenic myeloid CD11b(+)Gr1(+) cells","resumen":"The ability of synthetic oligodeoxynucleotides containing unmethylated cytosine guanine motifs (CpG-ODN) to induce both stimulatory and counter-regulatory responses offers novel opportunities for using these molecules as immunomodulatory agents in different therapeutic strategies. Here, we investigated the potential of CpG-ODN to activate the arginase (ARG) enzyme in vivo and focused on the consequences of this activation in T cell proliferation. Challenging mice via s.c. with CpG-ODN emulsified in incomplete Freund´s adjuvant (IFA) induced ARG and reduced T cell proliferation associated with CD3&#950; chain down-regulation. Interestingly, impaired T cell expansion correlated with elevated levels of CD11b+Gr1+ myeloid cells localized near T-cell areas in spleen. In addition, purified CD11b+ cells obtained from the spleen of CpG-ODN+IFA-treated mice exhibited increased ARG activity and  ARG I expression along with an augmented [3H]-L-arginine uptake. CD11b+ myeloid cells significantly suppressed T cell proliferation and CD3&#950; chain expression induced by a polyclonal stimulus. Furthermore, these effects could be recovered by the addition of excess L-arginine or by treatment of CD11b+ cells with a specific ARG inhibitor. This study provides a novel evidence that CpG-ODN+IFA are able to induce splenic CD11b+ cells with ARG activity, with this population being responsible for the impaired T-cell proliferation observed after the treatment with CpG-ODN+IFA. These results underscore a key role of CpG-ODN on ARG activity in vivo and add support to the growing body of evidence in favor of a counter-regulatory role for CpG-ODN in an immune response.","palabras_clave":"ARGINASA|CpG-ODN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89180,"idioma_id":4,"titulo":"Effect of plant preparations on lettuce yield","resumen":"Plant preparations are commonly used in organic horticulture. Herbal teas and broths are considered to be plant growth stimulating and disease suppressive. However, scarce scientific support is available. The aims of this work were to  evaluate the effect of onion (Allium cepa) and stinging nettle (Urtica dioica)  preparations on the growth of lettuce crops. The experiments were carried out in the Experimental Organic Orchard of the Faculty of Agronomy, University of Buenos Aires. The assays were planned as completely randomized blocks, with 6 replications per treatment. Lettuce (Lactuca sativa) cv. Criolla was sown in continuous rows (3 kg seeds\/ha) in each 1 m 2 minimum tillage experimental unit. Manual thinning out was required to reach an optimum number of plants per area. Onion and nettle preparations were obtained as follows. Broths were prepared by boiling 1 kg of chopped bulbs or leaves, respectively, in 10 L of water during 20 min, fermenting during 15 days, filtering and adding water to complete 10 L. Teas were prepared by chopping 1 kg of bulbs or leaves, respectively, adding 10 L of water, fermenting during 15 days, filtering and adding water to complete 10 L. Each preparation (diluted 1:20) was applied to the corresponding experimental units 3 times per week, during the whole crop cycle. Controls were treated with water. Plots treated with onion tea showed the highest leaf area and fresh head weight. Variations in the analyzed chemical components of the different plant preparations can, at least, partially explain these results. Further research is needed on the presence and role of organic compounds present in these preparations.","palabras_clave":"Lactuca sativa|onion |stinging nettle |broth-tea"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89181,"idioma_id":4,"titulo":"Micromammals and microinvertebrates records from Campo Laborde archaeological site (SOUTHEASTERN PAMPAS, ARGENTINA). Paleoecological and paleoenvironmental relationships.","resumen":"The firsts results ofthe integration of the two paleoenvironmental researches carried out for the sedimentary sequence of Campo Laborde archaeological siteare presented. The aims of this study were to identify the microvertebrates associations and to contributeinformation of species used like environmental markers during thehunter-gatherers' occupation of the site in the early Holocene. This data obtained from zooarchaeological andtaphonomical studies of the bone remains recovered from the site is alsocomplemented with indicator derived from the gastropodsrecorded throughout the stratigraphical sequence. The results of booths proxies\u2019 approachesshow the existence of arid condition temporally occupied by armadillos androdents in marginal sectors of a swamp and there is a considerable developmentof pedogenetic activity since a palustrine environment during human occupation.The obtained data indicates that the human populations occupied Campo Labordesite under the changing semiarid to humid climatic conditions during the earlyHolocene.","palabras_clave":"MICROMAMMALS|GASTEROPODS|TAPHONOMY|PALEOECOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89182,"idioma_id":4,"titulo":"Bioprospection of marine microorganisms: biotechnological applications and methods","resumen":"Environmental microorganisms constitute an almost inexhaustible reserve of genetic and functional diversity, accumulated during millions of years of adaptive evolution to various selective pressures. In particular, the extent of microbial biodiversity in marine habitats seems to grow larger as new techniques emerge to measure it. This has resulted in novel and more complex approaches for the screening of molecules and activities of biotechnological interest in these environments. In this review, we explore the different partially overlapping biotechnological fields that make use of microorganisms and we describe the different marine habitats that are particularly attractive for bioprospection. In addition, we review the methodological approaches currently used for microbial bioprospection, from the traditional cultivation techniques to state of the art metagenomic approaches, with emphasis in the marine environment.","palabras_clave":"BIOPROSPECTION|MARINE MICROORGANISMS|BIOTECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89183,"idioma_id":4,"titulo":"Bioprospection of marine microorganisms: potential and challenges for Argentina","resumen":"The marine environments of Argentina have a remarkable extension, as well as a high biological productivity and biodiversity of both macro- and microorganisms. Despite having a great potential for biotechnological applications, the microorganisms inhabiting these ecosystems remain mostly unexplored and unexploited. In this review, we study the research topics and the interactions among Argentinean laboratories, by analyzing the articles published by researchers of this country to date in biotechnology-related marine microbiology. In addition, we identify the challenges and opportunities for Argentina to take advantage of the genetic potential of its marine microorganisms. Lastly, we suggest possible actions that could improve the development of this research field, as well as the utilization of this knowledge to solve societal needs. &nbsp;","palabras_clave":"BIOPROSPECTION|ARGENTINA|MARINE MICROORGANISMS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89184,"idioma_id":4,"titulo":"Efficiency of Ovidia andina extracts in the control of the plant pathogen Rhizoctonia solani","resumen":"The evaluation of plant extracts as disease suppressive is an option to look  for alternative crop health management options. Pillo-pillo (Ovidia andina,  Thymelaeaceae) is native to southern Argentina and Chile. O. andina extracts  control plant damaging arthropods. Our objective was to evaluate O. andina  extracts for the control of the plant pathogen Rhizoctonia solani. Powdered and  dried aerial parts were successively extracted by maceration with dichloromethane (CH2Cl2) and methanol. Aqueous extract was obtained by decoction of aerial plant parts. The fungus was cultivated on PDA added with CH2Cl2 extract (diluted in CH2Cl2), methanolic, ethanolic and aqueous extract (diluted in ethanol), and hydrodistillation remaining water (diluted in H2O), all at 1:10 and 1:100 v\/v (controls: CH2Cl2, ethanol, water). Pathogen growth was significantly reduced by 1:10 CH2Cl2 extract, showing hyphal alterations. When five CH2Cl2 extract fractions diluted in CH2Cl2 were tested, fraction 5 showed equal efficiency as the whole extract. To evaluate extract effect on fungal colonization of plant organs, beetroot glomerules incubated in R. solani colonized soil were recovered, blotted dry and submerged in 1:10 CH2Cl2 extract for 30, 60, 90, 120, or 150 sec (controls: water, CH2Cl2). Glomerules were again recovered, blotted dry, and incubated on PDA for pathogen emergence. Infection was significantly reduced by extract treatments for 120 sec. These results are the basis of future greenhouse experiments and led us to continue with further phytochemical investigation of O. andina. Bioguided fractionation of the extracts will enable us to search for new antifungal compounds.","palabras_clave":"CH2Cl2 extract |fractions|fungal growth |cumarines-flavonoids"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89185,"idioma_id":5,"titulo":"Democratización subnacional: algunas preguntas teóricas","resumen":"Este artículo parte de un análisis de la literatura sobre democratización y de la discusión reciente sobre democratización subnacional para plantear algunas preguntas teóricas acerca de cómo pensar la democratización subnacional. Plantea una discusión acerca de qué es la democratización subnacional en tanto proceso diferenciado de la democratización nacional, y acerca de qué se entiende por autoritarismo subnacional. Para ello, discute la relación entre tres dimensiones centrales para el estudio de la democratización subnacional: el tipo de régimen nacional, el tipo de régimen subnacional y el rol del estado nacional. El artículo desglosa el concepto de autoritarismo subnacional y propone una nueva tipología de autoritarismo subnacional que consiste en: prácticas autoritarias subnacionales, situaciones autoritarias subnacionales y regímenes autoritarios subnacionales. A su vez, plantea el problema de cómo conceptualizar a un régimen nacional que contiene provincias\/estados menos democráticos o autoritarios.","palabras_clave":"SUBNACIONAL|DEMOCRATIZACIÓN|AUTORITARISMO|FEDERALISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89186,"idioma_id":4,"titulo":"Endozoochory decreases environmental filtering imposed to seedlings","resumen":"Questions: Recruitment microsites are imposed on plants, first by seed dispersal and then by the environment. Different seed dispersal vectors could decrease or increase the environmental filtering imposed on seedlings, depending on their specificity to deliver seeds to suitable microsites for germination and establishment. We addressed the hypothesis that endozoochory reduces the environmental filtering imposed to seedlings to a larger extent than does anemochory. We predicted that seedlings from animal-dispersed species should show a higher degree of environmental coupling. Location: Northern Patagonian Andean region of Argentina, 40-42 S. Methods: We characterized the relationship of seedlings, saplings and reproductive individuals to total radiation, air temperature and relative humidity for 16 woody species growing in 25 plant communities of different post-fire ages in temperate forests of southern South America. Results: Seedlings and saplings of endozoochorous species occurred under more similar environmental conditions than seedlings and saplings of anemochorous species. Basically, the mean difference in plant-environment correlation coefficients between saplings and seedlings was lower than 0.2 for all endozoochorous species and higher than 0.2 for all anemochorous species for all environmental variables. Comparisons between dispersal modes were also statistically significant before and after controlling for phylogenetic relationships among species. Even though saplings and seedlings of endozochorous species tended to occur under similar environmental conditions, we did not find evidence that saplings and seedlings co-occur in the same physical microsites. Finally, we did not find evidence either that seedlings of endozoochorous species tended to occur differentially underneath reproductive individuals of the same species (i.e. more seeds falling by gravity beneath maternal plants). Conclusions: The tighter coupling between seedlings of endozoochorous species and environmental factors persisting to the sapling stage suggests that relying on animals for seed dispersal reduces mortality costs during the early stages of recruitment by reducing the environmental filtering imposed on seedlings.","palabras_clave":"ANEMOCHORY|ECOLOGICAL FILTERS|ENVIRONMENTAL HETEROGENEITY|SAPLINGS|SEED DISPERSAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89187,"idioma_id":4,"titulo":"Hepatic lipase activity is increased in non- alcoholic fatty liver disease beyond insulin resistance","resumen":"BACKGROUND AND OBJECTIVE:Hepatic lipase is a lipolytic enzyme mostly synthesized and localized at the surface of liver sinusoidal capillaries, which hydrolyses triglycerides and phospholipids of intermediate density, large low density (LDL) and high density lipoproteins. Hepatic lipase activity is increased in insulin resistant states. Non-alcoholic fatty liver disease (NAFLD) is characterized by insulin resistance. However, at present, no data are available regarding the behaviour of hepatic lipase with regard to the degree of hepatic steatosis. Our aim was to evaluate hepatic lipase activity in NAFLD patients and its relationship to the severity of hepatic steatosis.DESIGN AND PATIENTS:We studied 48 patients with NAFLD (diagnosed by ultrasonography and confirmed by liver biopsy) and 30 controls. Steatosis was semi-quantitatively assessed and considered as mild or grade 1, moderate or grade 2 and severe or grade 3.MEASUREMENTS:hepatic lipase activity, lipid and lipoprotein profile (including intermediate density lipoproteins and dense LDL), adiponectin, insulin, glucose and high sensitivity C-reactive protein were measured. Homeostasis model assessment for insulin resistance (HOMA) index was calculated.RESULTS:Patients with hepatic steatosis presented with higher hepatic lipase activity, HOMA and dense LDL and lower levels of adiponectin, high density lipoproteins, cholesterol and apoA-I. Hepatic lipase activity positively correlated significantly with the severity of hepatic steatosis. Hepatic lipase correlated with a more atherogenic profile and persisted higher in patients even after corrected for age, gender, body mass index, HOMA and adiponectin.CONCLUSION:The higher hepatic lipase activity in NAFLD patients contributes to a more atherogenic profile linked to increased cardiovascular risk, beyond the insulin resistance and the reduction in adiponectin.","palabras_clave":"HEPATIC LIPASE|INSULINE RESISTANCE|NON-ALCOHOLIC FATTY LIVER|ADIPONECTIN|CARDIOVASCULAR RISK"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89188,"idioma_id":4,"titulo":"Cladosporium cladosporioides LPSC 1088 produces the 1,8-dihydroxynaphthalene-melanin-like compound and carries a putative pks gene","resumen":"Cladosporium cladosporioides is a dematiaceous fungus with coloured mycelia and conidia due to the  presence of dark pigments. The purpose of this study was to characterize the dark pigments synthetized by  Cladosporium sp. LPSC no. 1088 and also to identify the putative polyketide synthase (pks) gene that might  be involved in the pigment biosynthesis. Morphological as well as molecular features like the ITS sequence  confirmed that LPSC 1088 is Cladosporium cladosporioides . UV-visible, Fourier Transform Infrared (FTIR)  and Electron Spin Resonance (ESR) spectroscopy analysis as well as melanin inhibitors suggest that the main  dark pigment of the isolate was 1,8 dihydroxynaphthalene (DHN)-melanin-type compound. Two commercial  fungicides, Difenoconazole and Chlorothalonil, inhibited fungal growth as well as increased pigmentation of  the colonies suggesting that melanin might protect the fungus against chemical stress. The pigment is most  probably synthetized by means of a pentaketide pathway since the sequence of a 651 bp fragment, coding for  a putative polyketide synthase, is highly homologous to pks sequences from other fungi.","palabras_clave":"Cladosporium cladiosporioides|Polyketide synthesa|DHN Melanin|Fungicides"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89189,"idioma_id":5,"titulo":"Una nueva especie de Holmesina Simpson (Xenarthra, Cingulata, Pampatheriidae) del Pleistoceno de Rondônia, sudoeste de la Amazonia Brasil","resumen":"ABSTRACT ? NEW SPECIES OF HOLMESINA SIMPSON (XENARTHRA, CINGULATA, PAMPATHERIIDAE) FROMTHE PLEISTOCENE OF RONDÔNIA, SOUTHWEST AMAZONIA, BRAZIL. The Xenarthra Cingulata is one of the mostcharacteristic groups in the Neotropical region. These American endemic mammals comprise several families, among them,the Pampatheriidae (middle Miocene-early Holocene) which are characterized by sharing traits with both the Dasypodidaeand the Glyptodontidae. The genera Pampatherium Gervais & Ameghino and Holmesina Simpson, occur in both North andSouth America. In North America, the species H. floridanus, H. septentrionalis and P. mexicanum are recorded from the latePliocene to the Pleistocene, whereas H. occidentalis, H. paulacoutoi, H. majus, P. humboldtii and P. typum are recorded in thePleistocene of South America. New specie of the genus Holmesina is here proposed based on a skull without mandible foundat the locality Araras\/Periquitos, right margin of Madeira River, municipality of Vila Nova Mamoré, Rondônia State, from theRio Madeira Formation (late Pleistocene-Holocene). The new specie differs from the other species of the genera Holmesina andPampatherium by a series of distinctive morphological and allometric features: markedly slender skull, narrow straight nasals,slightly convex frontals, long parietals, and little developed sagittal crest. The zygomatic arch long and slender, without thelarge lateral area at orbital level observed in the other species, infraorbital process absent; temporal fossa wide and excavated\/deep; supraoccipital very high, deep, with external occipital crest prominent and lambdoid crest expanded posteriorly; palatenarrow, with imbrication molariforms between MF2, MF3 and MF4.","palabras_clave":"xenarthra|mammalia|Pleistoceno Brasil|Holmesina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89190,"idioma_id":4,"titulo":"Chalcones in Bioactive Argentine Propolis Collected in Arid Environments","resumen":"The aim of this study was to assess the chemical and biological profile of propolis samples collected in arid environments of north-western Argentina. The samples were from two phytogeographical regions (Prepuna and Monte de Catamarca Province). Propolis ethanolic extracts (PEE) and chloroform (CHL), hexane (HEX) and aqueous (AQ) sub-extracts of samples from three regions (CAT-I; CAT-II and CAT-III) were obtained. All PEE exhibited antioxidant activity in the DPPH radical scavenging assay (SC50 values between 28 and 43 £gg DW\/mL). The CHL extract was the most active (SC50 values between 10 and 37 £gg DW\/mL). The antioxidant activity in the ?Ò-carotene bleaching assays was more effective for PEE and CHL (IC50 values between 2 and 9 £gg DW\/mL, respectively). A similar pattern was observed for antibacterial activity. The highest inhibitory effect on the growth of human Gram-positive bacteria was observed for CHL-III and CHL-I (Monte region) with minimal inhibitory concentration values (MIC100) of 50 to 100 £gg DW\/mL. Nine compounds were identified by HPLC-PAD. Two of them (2¡¦, 4¡¦- dihydroxychalcone and 2¡¦,4¡¦- dihydroxy 3¡¦-methoxychalcone) were found only in propolis samples from the Monte phytogeographical region. We consider that the Argentine arid region is appropriate to place hives in order to obtain propolis of excellent quality because the dominant life forms in that environment are shrubby species that produce resinous exudates with a high content of chalcones, flavones and flavonols.           ","palabras_clave":"propolis|caracterization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89191,"idioma_id":5,"titulo":"Movilidad científica y reflexividad De cómo los desplazamientos de los investigadores modelan modos de producir conocimientos","resumen":"Este artículo, cuya versión en francés fue publicada el mismo año en la Revue d Anthropologie des Connassainces, Vol. 6, Nro. 2, forma parte de una edición conjunta entre ambas revistas.Este artículo se propone contribuir al debate en torno de la movilidad científica a partir de relatos de trayectorias profesionales de investigadores argentinos. La propuesta consiste en cartografiar los recorridos geográficos e institucionales de dos físicos a lo largo de sus carreras y analizar las formas de pensar, valorizar y hacer investigación que resultan, al menos en parte, de esos recorridos. Se parte de la base de que los desplazamientos de los científicos ponen en circulación, además de individuos, modos de producción de conocimientos. Modos que están constituidos por prácticas, valores e identificaciones colectivas e institucionales que participan en los procesos de producción de la ciencia. En ese sentido, los desplazamientos posicionan a los investigadores en relación a sus actividades creando diferencias respecto de aquello que producen, sus objetivos y de las miradas sobre sus contextos de trabajo. A partir de este análisis discutiremos, además, uno de los ejes explicativos de las direcciones que guían la movilidad de científicos: la distinción entre centro(s) y periferia(s) abriendo la reflexión en otras direcciones a profundizar. ","palabras_clave":"MOVILIDAD CIENTIFICA|TRAYECTORIAS PROFESIONALES|GEOGRAFÍAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89192,"idioma_id":6,"titulo":"Mobilité scientifique et réflexivité des chercheurs. Comment les déplacements façonnent des modes de production de connaissances","resumen":"NOTA: Revista indexada por la Agence d'évaluation de la recherche et de l'enseignement supérieur (AERES) en la 'Liste Sociologie - Démographie'. Ver : http:\/\/www.aeres-evaluation.fr\/Publications\/Methodologie-de-l-evaluation\/Listes-de-revues-SHS-sciences-humaines-et-sociales&nbsp;---&nbsp; RESUMEN: 'Cet article se propose de contribuer aux débats concernant la circulation des scientifiques à partir de récits de trajectoires professionnelles de chercheurs argentins. La proposition consiste à cartographier les parcours géographiques et institutionnels de deux physiciens tout au long de leur carrière, et à analyser les façons de penser, valoriser et faire de la recherche qui résultent, au moins en partie, de ces parcours. Elle pose l´hypothèse que les déplacements des scientifiques mettent en circulation des modes de production de connaissances. Ces derniers sont constitués de pratiques, de valeurs et d´identifications collectives et institutionnelles, qui participent des processus de production de connaissances. Ils positionnent les chercheurs au regard de leur activité, en créant des différences à propos de ce qu´ils produisent, leurs objectifs et leurs regards sur leur contexte de travail. A partir de ces analyses, nous discutons un des axes explicatifs de la mobilité scientifique, la distinction entre centre(s) et périphérie(s), et nous proposons de nouveaux axes de réflexion pour approfondir l´analyse de la relation entre mobilité scientifique et modes de production de connaissances.' ","palabras_clave":"GEOGRAPHIES|MOBILITE SCIENTIFIQUE|PRODUCTION DE CONNAISSANCES|TRAJECTOIRES PROFESSIONNELLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89193,"idioma_id":4,"titulo":"Alkane Biodegradation Genes from Chronically Polluted Subantarctic Coastal Sediments and Their Shifts in Response to Oil Exposure","resumen":"Although sediments are the natural hydrocarbon sink in the marine environment, the ecology of hydrocarbon-degrading bacteria in sediments is poorly understood, especially in cold regions. We studied the diversity of alkane-degrading bacterial populations and their response to oil exposure in sediments of a chronically polluted Subantarctic coastal environment, by analyzing alkane monooxygenase (alkB) gene libraries. Sequences from the sediment clone libraries were affiliated with genes described in Proteobacteria and Actinobacteria, with 67 % amino acid identity in average to sequences from isolated microorganisms. The majority of the sequences were most closely related to uncultured microorganisms from cold marine sediments or soils from high latitude regions, highlighting the role of temperature in the structuring of this bacterial guild. The distribution of alkB sequences among samples of different sites and years, and selection after experimental oil exposure allowed us to identify ecologically relevant alkB genes in Subantarctic sediments, which could be used as biomarkers for alkane biodegradation in this environment. 16 S rRNA amplicon pyrosequencing indicated the abundance of several genera for which no alkB genes have yet been described (Oleispira, Thalassospira) or that have not been previously associated with oil biodegradation (Spongiibacter formerly Melitea, Maribius, Robiginitomaculum, Bizionia and Gillisia). These genera constitute candidates for future work involving identification of hydrocarbon biodegradation pathway genes.","palabras_clave":"SUBANTARCTIC ENVIRONMENTS|COASTAL SEDIMENTS|ALKANE MONOOXYGENASE|OIL RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89194,"idioma_id":4,"titulo":"Abundance, Dynamics and Biogeographic Distribution of Seven Polycyclic Aromatic Hydrocarbon Dioxygenase Gene Variants in Coastal Sediments of Patagonia","resumen":"Novel polycyclic aromatic hydrocarbon dioxygenase gene variants were present in abundances similar to or higher than those of phnA1 from Cycloclasticus spp. at a chronically polluted subantarctic coastal marine environment in Patagonia. These novel gene variants were detected over a 6-year time span and were also present in sediments from temperate Patagonian sites","palabras_clave":"POLYCYCLIC AROMATIC HYDROCARBONS (PAHs)|MARINE SEDIMENTS|PAH DIOXYGENASE GENES|QPCR|SUBANTARCTIC ENVIRONMENTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89195,"idioma_id":4,"titulo":"Effects of the Ti\/Fe ratio on the phase composition and magnetic properties of mechanochemically activated Ti-Fe2O3 mixtures","resumen":"The mechanochemical activation of Ti\/Fe2O3 powder   mixtures with molar ratio 1 and 1.5 was performed with the aim of   understanding the effects of the starting composition on the reactivity   and structure of the produced phases. The solid mixture was   characterized by scanning electron microscopy, X-ray diffraction,   vibrating sample magnetometry and Mössbauer spectroscopy. The   consumption of the reactants and the formation of metallic iron are   observed at short activation times. After 3&nbsp;h, the redox reaction   completes, yielding a composite powder formed by nanocrystalline Fe   particles dispersed in an oxide matrix. The mixture with the highest   Ti\/Fe ratio leads to the formation of a TiO2 matrix, whereas the other composition forms FeTiO3.   Both composite materials have very high saturation magnetization and   moderate coercivities. Under subsequent thermal treatment at 700&nbsp;°C, the   activated solids show a progressive crystalline ordering with partial   oxidation of Fe (mainly to FeTiO3 and Fe2O3) and crystallization into the rutile phase of TiO2. This leads to a significant decrease of magnetization and coercivity.","palabras_clave":"COMPOSITE MATERIALS|MOSSBAUER SPECTROSCOPY|MAGNETOMETER|MAGNETIC PROPERTIES|MECHANOCHEMISTRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89196,"idioma_id":4,"titulo":"Aromatic compound-dependent Staphylococcus aureus is safe in a nasal colonization leukopenic murine model","resumen":"Staphylococcus aureus nasal carriage is a risk factor for individuals   suffering from trauma, surgical procedures, invasive devices, and\/or   decreased immunity. Recently, we demonstrated that artificial nasal   colonization with an attenuated S. aureus mutant reduced by bacterial   interference with the colonization of pathogenic strains of S. aureus.   This could be an optional tool to diminish the rate of S. aureus   infections in hospitalized patients. The aim of this study was to   construct a safe &#916;aroA mutant of S. aureus and to discriminate it from   nasal colonizing and osteomyelitis S. aureus isolates by SmaI   pulsed-field gel electrophoresis (PFGE) typing. The &#916;aroA mutant, named   RD17, exhibited an LD(50) (3.2 × 10(6) colony-forming unit (CFU))   significantly higher than that of the parental strain (2.2 × 10(3)&#8201;CFU).   The colony number of the RD17 mutants recovered from nares of   leukopenic mice was similar to that observed in the animals of the   control group. Therefore, the &#916;aroA mutant was demonstrated to be safe   due to maintaining low growth levels in the nares regardless of immune   status of the animals. PFGE typing allowed the unequivocal   identification of the S. aureus and differentiation of aroA mutants in   nasal colonizing and osteomyelitis isolates. This information could be   important to discriminate endogenous infections from laboratory strains   of S. aureus.","palabras_clave":"STAPHYLOCOCCUS AUREUS|AROMATIC|COLONIZATION|ANIMAL MODEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89197,"idioma_id":4,"titulo":"A LOV Protein Modulates the Physiological A ttributes of Xanthomonas axonopodis pv citri Relevant for Host Plant Colonization","resumen":"Recent studies have demonstrated that an appropriate light environment is required for the establishment of efficient vegetal resistance responses in several plant-pathogen interactions. The photoreceptors implicated in such responses are mainly those belonging to the phytochrome family. Data obtained from bacterial genome sequences revealed the presence of photosensory proteins of the BLUF (Blue Light sensing Using FAD), LOV (Light, Oxygen, Voltage) and phytochrome families with no known functions. Xanthomonas axonopodis pv. citri is a Gram-negative bacterium responsible for citrus canker. The in silico analysis of the X. axonopodis pv. citri genome sequence revealed the presence of a gene encoding a putative LOV photoreceptor, in addition to two genes encoding BLUF proteins. This suggests that blue light sensing could play a role in X. axonopodis pv. citri physiology. We obtained the recombinant Xac-LOV protein by expression in Escherichia coli and performed a spectroscopic analysis of the purified protein, which demonstrated that it has a canonical LOV photochemistry. We also constructed a mutant strain of X. axonopodis pv. citri lacking the LOV protein and found that the loss of this protein altered bacterial motility, exopolysaccharide production and biofilm formation. Moreover, we observed that the adhesion of the mutant strain to abiotic and biotic surfaces was significantly diminished compared to the wild-type. Finally, inoculation of orange (Citrus sinensis) leaves with the mutant strain of X. axonopodis pv. citri resulted in marked differences in the development of symptoms in plant tissues relative to the wild-type, suggesting a role for the Xac-LOV protein in the pathogenic process. Altogether, these results suggest the novel involvement of a photosensory system in the regulation of physiological attributes of a phytopathogenic bacterium. A functional blue light receptor in Xanthomonas spp. has been described for the first time, showing an important role in virulence during citrus canker disease.","palabras_clave":"BACTERIAL BLUE LIGHT PHOTORECEPTOR|LOV PROTEIN|XANTHOMONAS AXONOPODIS PV. CITRI|CITRUS CANKER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89198,"idioma_id":4,"titulo":"ASSOCIATION BETWEEN BoLA-DRB3 AND SOMATIC CELL COUNT IN HOLSTEIN CATTLE FROM ARGENTINA","resumen":"Different studies have proved that the resistance\/susceptibility to mastitis is genetically determined. The Major Histocompatibility Complex (MHC) in cows is known as Bovine Lymphocyte Antigen (BoLA). Genes from the BoLA have been associated with the occurrence of infectious diseases such as mastitis and leukosis, especially the BoLA-DRB gene. The object of the present study was to detect associations between BoLA-DRB3 alleles and somatic cell count (SCC), as an indicator of resistance\/susceptibility to mastitis in Holstein cattle (N=123) from La Pampa, Argentina. Fisher?s exact test and Woolf?Haldane odds ratio (OR) were applied to study the association between SCC and BoLA-DRB3 allele frequencies. Significant association was noted between BoLA-DRB3.2*23 and *27 alleles (p &lt; 0.05) and protective or susceptibility effects, respectively. In addition, alleles BoLA-DRB3.2*20 and *25 exhibit suggestive association with high SCC (p &lt; 0.1). These results were partially in agreement with data reported from Japanese Holstein cattle, but differed from those published by other authors. A possible explanation for the contrasting results could be that the mastitis is a multifactor disease caused by different pathogens. Moreover, most of the studies were carried out using PCR-RFLP method, which has less resolution than PCR-SBT because PCR-RFLP defined alleles included more than one sequenced alleles. ","palabras_clave":"BOLA-DRB3|MASTITIS|RESISTANCE\/SUSCEPTIBILITY|SOMATIC CELL STORE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89199,"idioma_id":4,"titulo":"The molecular gas around the luminous blue variable star G24.73+0.69","resumen":"Aims: We study the molecular environment of the luminous bluevariable star G24.73+0.69 to investigate the origin of the two infraredshells around this massive star and determine its effects on thesurrounding interstellar medium.  Methods: We analyze thedistribution of the molecular gas using the 13CO J = 1-0emission extracted from the Galactic Ring Survey. We use near- andmid-infrared data from 2MASS and GLIMPSE to identify the young stellarobjects in the field.  Results: We discover the molecularcounterpart to the outer infrared shell around G24.73+0.69. The CO shellwas probably blown by the stellar wind of the star mainly during itsmain sequence phase. We also find molecular gas that corresponds to theinner infrared shell, although its origin remains uncertain. We identifyseven young stellar objects within the molecular material, whose birthmight have been triggered by the stellar wind of the luminous bluevariable star. We suggest that both G24.73+0.69 and the progenitor ofthe nearby supernova remnant G24.7+0.6 were formed from the same natalcloud and represent the most evolved members of a so far undetectedcluster of massive stars.","palabras_clave":"STARS: INDIVIDUAL: G24.73+0.69|STARS: WINDS|STARS: OUTFLOWS|ISM: CLOUDS|STARS: FORMATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89200,"idioma_id":4,"titulo":"Study of the dense molecular gas surrounding the 'Extended Green Object' G35.03+0.35","resumen":"We present the results of a new study of the molecular gas associatedwith the 'extended green object' (EGO) G35.03+0.35. This object, verylikely a massive young stellar object, is embedded in a molecular cloudat the border of an H II region. The observations were performed withthe Atacama Submillimeter Telescope Experiment in the 12COand 13CO J= 3-2, HCO+ J= 4-3 and CS J= 7-6 lineswith an angular resolution of about 22 arcsec. From the 12COJ= 3-2 line, we discovered outflowing activity of the massive youngstellar object. We obtained a total mass and kinetic energy for theoutflows of 30 and 3000 Msun (kms-1)2 (6 × 1046 erg),respectively. We discovered an HCO+ and CS clump towards theEGO G35.03+0.35. The detection of these molecular species supports thepresence of molecular outflows and a dense molecular envelope withtemperatures and densities above 40 K and 6 × 106cm-3, respectively. Using public near- and mid-infrared andsubmillimetre data, we investigated the spectral energy distributionconfirming that EGO G35.03+0.35 is a massive young stellar object at itsearliest evolutionary stage (i.e. a class I young stellar object). Byanalysing radio-continuum archival data, we found three radio sourcestowards the object, suggesting the presence of several young stellarobjects in the region. Our radio-continuum analysis is consistent withthe presence of at least one ultracompact H II region and a hypercompactH II region or a constant-velocity ionized wind source.","palabras_clave":"ISM: CLOUDS|H II REGIONS|ISM: JETS AND OUTFLOWS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89201,"idioma_id":4,"titulo":"Study of the luminous blue variable star candidate G26.47+0.02 and its environment","resumen":"Aims: The luminous blue variable (LBV) stars are peculiar very  massive stars. The study of these stellar objects and their surroundings  is important for understanding the evolution of massive stars and its  effects on the interstellar medium. We study the LBV star candidate  G26.47+0.02.  Methods: Using several large-scale surveys in  different frequencies we performed a multiwavelength study of  G26.47+0.02 and its surroundings.  Results: We found a molecular  shell (seen in the 13CO J = 1-0 line) that partially  surrounds the mid-infrared nebula of G26.47+0.02, which suggests an  interaction between the strong stellar winds and the molecular gas. From  the HI absorption and the molecular gas study we conclude that  G26.47+0.02 is located at a distance of ~4.8 kpc. The radio continuum  analysis shows both thermal and non-thermal emission toward this LBV  candidate, pointing to wind-wind collision shocks from a binary system.  This hypothesis is supported by a search of near-IR sources and the  Chandra X-ray analysis. Additional multiwavelength and long-term  observations are needed to detect some possible variable behavior, and  if that is found, to confirm the binary nature of the system.","palabras_clave":"STARS: INDIVIDUAL: G26.47+0.02|STARS: WINDS, OUTFLOWS|ISM: CLOUDS|STARS: MASSIVE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89202,"idioma_id":4,"titulo":"The molecular clump towards the eastern border of SNR G18.8+0.3","resumen":"The eastern border of the SNR G18.8+0.3, close to an HII regions complex, is  a very interesting region to study the molecular gas that it is probably in  contact with the SNR shock front. We observed the aforementioned region using  the Atacama Submillimeter Telescope Experiment (ASTE) in the 12CO J=3-2, 13CO  J=3-2, HCO+ J=4-3, and CS J=7-6 lines with an angular resolution of 22'. To  complement these observations, we analyzed IR, submillimeter and radio  continuum archival data. In this work, we clearly show that the radio continuum  'protrusion' that was early thought to belong to the SNR is an HII regions  complex deeply embedded in a molecular clump. The new molecular observations  reveal that this dense clump, belonging to an extended molecular cloud that  surrounds the SNR southeast border, is not physically in contact with SNR  G18.8+0.3, suggesting that the SNR shock front have not yet reached it or maybe  they are located at different distances. We found some young stellar objects  embedded in the molecular clump, suggesting that their formation should be approximately coeval with the SN explosion.","palabras_clave":"ISM: clouds|ISM: SNR|star formation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89203,"idioma_id":4,"titulo":"Evaluating sampling completeness in a desert plant-pollinator network","resumen":"The study of plant-pollinator interactions in a network context is receiving increasing attention. This approach has helped to identify several emerging network patterns such as nestedness and modularity. However, most studies are based only on qualitative information, and some ecosystems, such as deserts and tropical forests, are underrepresented in these data sets.  We present an exhaustive analysis of the structure of a four-year plant-pollinator network from the Monte  desert in Argentina using qualitative and quantitative tools. We describe the structure of this network and  evaluate sampling completeness using asymptotic species richness estimators. Our goal is to assess the extent to  which the realised sampling eort allows for an accurate description of species interactions and to estimate the minimum number of additional censuses required to detect 90% of the interactions. We evaluated completeness of detection of the community-wide pollinator fauna, of the pollinator fauna associated to each plant species and of the plant-pollinator interactions. We also evaluated whether sampling completeness was infuenced by plant characteristics, such as ower abundance, ower life span, number of interspecic links (degree) and selectiveness in the identity of their ower visitors, as well as sampling effort.  We found that this desert plantpollinator network has a nested structure and that it exhibits modularity and high network-level generalisation.  In spite of our high sampling effort, and although we sampled 80% of the pollinator fauna, we recorded only 55% of the interactions. Furthermore, although a 64% increase in sampling eort would suce to detect 90% of  the pollinator species, a 5-fold increase in sampling eort would be necessary to detect 90% of the interactions.  Detection of interactions was incomplete for most plant species, particularly specialists with a long owering season and high ower abundance, or generalists with short owering span and scant owers. Our results suggests that sampling of a network with the same eort for all plant species is inadequate to sample interactions.  Sampling the diversity of interactions is labor intensive, and most plantpollinator networks published to date are likely to be undersampled. Our analysis allowed estimating the completeness of our sampling, the  additional effort needed to detect most interactions and the plant traits that influence the detection of their interactions.","palabras_clave":"Argentina|generalization|interaction web|mendoza"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89204,"idioma_id":4,"titulo":"The strength of plant-pollinator interactions","resumen":"Recent studies of plant--animal  mutualistic networks have assumed that interaction frequency between  mutualists predicts species impacts (population-level effects), and  that field estimates of interaction strength (per-interaction  effects) are unnecessary. Although existing evidence supports this  assumption for the effect of animals on plants, no studies have  evaluated it for the reciprocal effect of plants on animals. We  evaluate this assumption using data on the reproductive effects of  pollinators on plants and the reciprocal reproductive effects of  plants on pollinators. The magnitude of species impacts of plants on  pollinators, the reciprocal impacts of pollinators on plants, and  their asymmetry were well predicted by interaction frequency.  However, interaction strength was key to determine the sign of  species impacts. These results underscore the importance of  quantifying interaction strength in studies of mutualistic networks.  We also show that the distributions of interaction strengths and  species impacts are highly skewed, with few strong and many weak  interactions. This skewed distribution matches the pattern observed  in food webs, suggesting that the community-wide organization of  species interactions is fundamentally similar between mutualistic and  antagonistic interactions. Our results have profound ecological  implications, given the key role of interaction strength for  community stability.               ","palabras_clave":"asymmetry|ecological networks|interaction frequency|interaction strength|Monte desert|mutualism|plant-pollinator interactions|pollination|species impact"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89205,"idioma_id":5,"titulo":"Catolicismo y trabajo femenino: una aproximación desde la prensa del sudoeste bonaerense argentino a principios del siglo XX","resumen":"En el presente artículo se analizan las representaciones de género sobre el trabajo femenino en la prensa de tendencia católica que aparece en Bahía Blanca (Provincia de Buenos Aires, Argentina) y circula por su zona de influencia durante las tres primeras décadas del siglo XX. Se postula que los\/as católicos\/as comparten el concepto de diferencia sexual dominante en la época y abordan el problema del trabajo de las mujeres centrándose en las nociones de maternidad y domesticidad pero las reformulan frente a los nuevos procesos de la modernización, como resultado de lo cual expresan algunas ideas que, si bien no tienen en sí mismas la intención de subvertir las relaciones de género, avalan ciertas mutaciones de signo moderno en la condición femenina.","palabras_clave":"ARGENTINA|MUJERES|TRABAJO|CATOLICISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89206,"idioma_id":4,"titulo":"Neural network-based compensation control of mobile robots with partially known structure","resumen":"This study proposes an inverse non-linear controller combined with an adaptive neural network proportional integral (PI) sliding mode using an on-line learning algorithm. The neural network acts as a compensator for a conventional inverse controller in order to improve the control performance when the system is affected by variations on their dynamics and kinematics. Also, the proposed controller can reduce the steady-state error of a non-linear inverse controller using the on-line adaptive technique based on Lyapunov\u2019s theory. Experimental results show that the proposed method is effective in controlling dynamic systems with unexpected large uncertainties.","palabras_clave":"Mobile robots|Neural networks|Compensators"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89207,"idioma_id":4,"titulo":"Quantum-mechanical interference in charge exchange between hydrogen and graphene-like surfaces","resumen":"The neutral to negative charge fluctuation of a hydrogen atom in front   of a graphene surface is calculated by using the Anderson model within   an infinite intra atomic Coulomb repulsion approximation. We perform an ab&nbsp;initio   calculation of the Anderson hybridization function that allows   investigation of the effect of quantum-mechanical interference related   to the Berry phase inherent to the graphene band structure. We find that   consideration of the interaction of hydrogen on top of many C atoms   leads to a marked asymmetry of the imaginary part of the hybridization   function with respect to the Fermi level. Consequently, Fano factors   larger than one and strongly dependent on the energy around the Fermi   level are predicted. Moreover, the suppression of the hybridization for   energies above the Fermi level can explain the unexpected large negative   ion formation measured in the scattering of protons by graphite-like   surfaces.","palabras_clave":"Quantum-mechanical interference|charge exchange"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89208,"idioma_id":4,"titulo":"Localization status of hepatocellular transporters in cholestasis","resumen":"         TABLE OF CONTENTS1. Abstract  2. Introduction  3. Hepatocellular transporters and their role in bile formation  3.1. Sinusoidal transporters  3.2. Canalicular transporters  3.3. Water transporters  4. Alterations of the dynamic localization of transporters in cholestasis4.1. Endocytic internalization of transporters in experimental cholestasis4.1.1. Bile duct ligation (BDL)  4.1.2. Drug-induced cholestasis4.1.3. Oxidative stress-induced cholestasis4.1.4. Lipopolysaccharide (LPS)-induced cholestasis4.2. Endocytic internalization of transporters in human cholestatic liver disease5. Mechanisms of endocytic internalization of transporters in cholestasis5.1. Structural basis  5.2. Role for signaling pathways6. Anticholestastic therapeutic approaches based upon modulation of dynamic transporter localization6.1. cAMP  6.2. Tauroursodeoxycholate (TUDC)  7. Perspectives  8. Acknowledgements  9. References           1. ABSTRACT          Vectorial transport of osmotically active solutes from blood into bile is essential for bile flow generation. Therefore, the localization status of hepatocellular transporters involved in this function is critical. These transporters are localized either in the plasma membrane or in an endosomal, submembranous compartment, from where they undergo recycling to the plasma membrane.   The balance between exocytic targeting\/endocytic internalization   from\/to this recycling compartment is therefore a chief determinant of   the liver capability to secrete bile.   Furthermore, its impairment may lead to sustained endocytic   internalization, eventually resulting in transporter degradation.   Exacerbated internalization of hepatocellular transporters occurs in   several experimental models of cholestasis, and also in most human cholestatic liver diseases. This review outlines the possible mechanisms explaining this alteration (e.g., alteration of the organization of actin or actin-transporter linking proteins), and the mediators involved (e.g., activation of 'cholestatic' signaling pathways).   Finally, several experimental therapeutic approaches based upon the   administration of compounds that stimulate exocytic targeting of   canalicular transporters (e.g., cAMP, tauroursodeoxycholate) are   described with regard to their capability to prevent cholestatic   alterations resulting from transporter internalization.  ","palabras_clave":"Transporters|Cholestasis|exocytosis |endocytosis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89209,"idioma_id":4,"titulo":"ERK1\/2 and p38 MAPKs ARE COMPLEMENTARILY INVOLVED IN ESTRADIOL 17ß- D-GLUCURONIDE-INDUCED CHOLESTASIS: CROSSTALK WITH cPKC AND PI3K","resumen":"Objective: The endogenous, cholestatic metabolite estradiol 17ß-D-glucuronide (E217G)induces endocytic internalization of the canalicular transporters relevant to bile formation,Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect.Design: ERK1\/2, JNK1\/2, and p38 MAPK activation was assessed by the increase in theirphosphorylation status. Hepatocanalicular function was evaluated in isolated rat hepatocytecouplets (IRHCs) by quantifying the apical secretion of fluorescent Bsep and Mrp2substrates, and in isolated, perfused rat livers (IPRLs), using taurocholate and 2,4-dinitrophenyl-S-glutathione, respectively. Protein kinase participation in E217G-inducedsecretory failure was assessed by co-administering selective inhibitors. Internalization ofBsep\/Mrp2 was assessed by confocal microscopy and image analysis.Results: E217G activated all kinds of MAPKs. The PI3K inhibitor wortmannin preventedERK1\/2 activation, whereas the cPKC inhibitor Gö6976 prevented p38 activation,suggesting that ERK1\/2 and p38 are downstream of PI3K and cPKC, respectively. The p38inhibitor SB203580 and the ERK1\/2 inhibitor PD98059, but not the JNK1\/2 inhibitorSP600125, partially prevented E217G-induced changes in transporter activity andlocalization in IRHCs. p38 and ERK1\/2 co-inhibition resulted in additive protection,suggesting complementary involvement of these MAPKs. In IPRLs, E217G inducedendocytosis of canalicular transporters and a rapid and sustained decrease in bile flow andbiliary excretion of Bsep\/Mrp2 substrates. p38 inhibition prevented this initial decay, andthe internalization of Bsep\/Mrp2. Contrarily, ERK1\/2 inhibition accelerated the recovery ofbiliary secretion and the canalicular reinsertion of Bsep\/Mrp2.","palabras_clave":"estradiol 17ß-D-glucuronide|cholestasis|canalicular transporter internalization|p38 MAPK|ERK1\/2|PI3K|cPKC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89210,"idioma_id":4,"titulo":"Genetic population structure and trichothecene genotypes of Fusarium graminearum isolated from wheat in Southern Brazil","resumen":"A sample of 140 Fusarium graminearum isolates from Rio Grande do Sul, Brazil, representing three populations at least 150 km from one other, were examined for trichothecene genotype based on PCR amplification of portions of the Tri3,Tri12 genes and a species-specific (Fg16F&#8260; R) primer. Genetic diversity was assessed in a sample of 103 F. graminearum lineage 7 (F. graminearum sensu stricto) isolates using amplified fragment length polymorphism (AFLP) markers. The 15-ADON genotype was dominant, followed by the NIV genotype (2\u201318% prevalence), across all three populations. All NIV-type isolates were in lineage 2 (F. meridionale) and all 15-ADON-type isolates were in lineage 7. Isolates with the same haplotype were rare and genotypic diversity was uniformly high (\u202198% of the count), suggesting that recombination has played a significant role. The number of migrants (Nm) was estimated between 5 and 6 across all loci and all populations, but the high frequency of private alleles (up to 30%) suggests a historical, rather than contemporary, gene flow. Regarding linkage disequilibrium, 0Æ8, 1Æ5 and 2Æ2% of the locus pairs from the three populations were in disequilibrium, which is lower than values reported in other locations. Thus, Brazilian populations differ from those found in Europe, North America and most of Asia in the presence of a significant frequency (7Æ8%) of isolates of theNIVgenotype in lineage 2 ","palabras_clave":"CHEMOTYPE  |DEOXYNIVALENOL|GIBBERELLA ZEAE|SMALL GRAINS|TRITICUM AESTIVUM|WHEAT SCAB"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89211,"idioma_id":4,"titulo":"Natural occurrence of alternariol and alternariol monomethyl ether in soya beans","resumen":"The natural occurrence of alternariol (AOH) and alternariol monomethyl ether (AME) in soya beans harvestedin Argentina was evaluated. Both toxins were simultaneously detected by using HPLC analysis coupled with a solid phase extraction column clean-up. Characteristics of this in-house method such as accuracy, precision and detection and quantification limits were defined by means of recovery test with spiked soya bean samples. Out of 50 soya bean samples, 60% showed contamination with the mycotoxins analyzed; among them, 16% were only contaminated with AOH and 14% just with AME. Fifteen of the positive samples showed co-occurrence of both mycotoxins analyzed. AOH was detected in concentrations ranging from 25 to 211 ng\/g, whereas AME was found in concentrations ranging from 62 to 1,153 ng\/g. Although a limited number of samples were evaluated, this is the first report on the natural occurrence of Alternaria toxins in soya beans and is relevant from the point of view of animal public health.Alternaria toxins in soya beans and is relevant from the point of view of animal public health.","palabras_clave":"ALTERNARIA ALTERNATA|ALTERNARIOL|ALTERNARIOL MONOMETHYL ETHER|SOYA BEAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89212,"idioma_id":4,"titulo":"Impact of cycling temperatures on Fusarium verticillioides and Fusarium graminearum growth and mycotoxins production in soybean","resumen":"Fusarium graminearum and F. verticillioides are two very important mycotoxigenic species as they cause diverse diseases in crops. The effect of constant and cycling temperatures on growth and mycotoxin production of these species were studied on soybean based medium and on irradiated soya beans. Fusarium graminearum grew better when was incubated at 15, 20 and 15-20 ºC (isothermal or cycling temperature). With respect to F. verticillioides, grew better at 25 ºC in culture medium and at 15-20 ºC, 15-25 ºC on soybean seeds. Besides, mycotoxins production was higher under isothermal temperatures compared to cycling temperatures. Maximum levels of zearalenone (ZEA) and deoxynivalenol (DON) (39.25 and 1040.4 µg\/g, respectively) were detected on soya beans after 15 days of incubation. However, optimum temperature for mycotoxin production was different for each toxin: 15 ºC for ZEA and 20 ºC for DON. On the other side, F. verticillioides only produced fumonisin B1 (FB1) on culture medium, and the maximum level (7.38 µg\/g) was found at 15 ºC after 7 days of incubation. Finally, growth and mycotoxin production under cycling temperatures were predicted with the sum of 12 hours under constant condition. In general, observed values were different from calculated (p&lt;0.05) for both species and substrate medium. Therefore, care should be taken when data are extrapolated to real field conditions from constant growth conditions.          ","palabras_clave":"FUSARIUM GRAMINEARUM|FUSARIUM VERTICILLIOIDES|SOYBEAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89213,"idioma_id":4,"titulo":"Control of ochratoxin A production in grapes","resumen":"Ochratoxin A (OTA) is a mycotoxin commonly present in cereals, grapes, coffee, spices, and cocoa. Even though the main objective of the food and feed chain processors and distributors is to avoid the extended contamination of plant-derived foods and animal feeds with mycotoxins, until now, complete OTA removal from foods and feedstuffs is not feasible. Prevention through pre-harvest management is the best method for controlling mycotoxin contamination. However, in the case that the contamination occurs after this stage, the hazards associated with OTA must be managed through post-harvest strategies. Due to the increasing number of fungal strains resistant to chemical fungicides and the impact of these pesticides on the environment and human health, maximum levels of chemical residues have been regulated in many products. Alternative methods are necessary to substitute or complement treatments with fungicides to control fungi under field or storage conditions. Yeasts are considered one of the most potent biocontrol agents due to their biology and non-toxic properties. Epiphytic yeasts are the major component of the microbial community on the surface of grape berries and they are evolutionarily adapted to this ecological niche. Nowadays, several yeast species included in different genera are considered as potential biocontrol agents to control both, growth of ochratoxigenic Aspergillus species and OTA accumulation.","palabras_clave":"Ochratoxin A|prevention strategy|fungicides|biological control"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89214,"idioma_id":4,"titulo":"Block Copolymer Concentration Gradient and Solvent Effects on Nanostructuring of Thin Epoxy Coatings Modified with Epoxidized Styrene&#8722;Butadiene&#8722;Styrene Block Copolymers","resumen":"The gradient on block copolymer concentration through film thickness as well as the effects of casting solvents used on the nanostructuring of a thermosetting epoxy coating modified with an epoxidized poly(styrene-b-butadiene-bstyrene) (SBS) triblock copolymer was studied by means of atomic force microscopy and attenuated total reflectance infrared spectroscopy. Thin coating films based on a commercial epoxy&#8722;amine formulation consisting of diglycidyl ether of bisphenol A and a low-temperature fast curing amine were modified with several amounts of epoxidized SBS triblock copolymer. Toluene and a mixture of tetrahydrofuran and N,N-dimethylformamide were used as casting solvents. With epoxidation degrees higher than 45 mol % of polybutadiene block nanostructuring was achieved. Fast curing rate of the epoxy\/amine system and the comparatively slow evaporation rate of the casting solvent led to a gradient of morphologies through the film cross section owing to the coalescence of small micelles into larger micellar domains in the case of low block copolymer content. For these reasons, different morphologies were also obtained in the midtransverse section of a film with variable thickness. Finally, pseudolamellar nanostructure at high copolymer contents was achieved as confirmed by parallel and perpendicular cuttings to the air\/polymer interface. ","palabras_clave":"BLOCK COPOLYMERS|NANOTECHNOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89215,"idioma_id":5,"titulo":"El indigenismo argentino de Rodolfo Kusch desde la  crítica postestructuralista","resumen":"El presente escrito se propone reflexionar sobre el tratamiento y la construcción discursiva de la categoría americano en la bibliografía indigenista argentina de Rodolfo Kusch,principalmente en su producción de las décadas posteriores al Peronismo de los años 50, 60 y 70. La crítica se establece desde puntos nodales vinculados a autores postestructuralista particularmente desde una postura antiesencialista puntualizando en la cuestión de la identidad y la diferencia. Kusch, al tiempo que pone sobre la mesa la cuestión indígena, en un país como Argentina sin tradición indigenista, apuesta a la búsqueda de la especificidad del sujeto y del pensamiento en el suelo americano,basándose en la reflexión estrechamente ligada a la retórica del existencialismo y particularmente desde la obra Heidegger. Esta es la arista filosófica que se someterá a crítica respecto a la figura que hoy se reivindica como uno de los primeros indigenistas argentinos o se critica por su abigarrado carácter eurocéntrico.","palabras_clave":"INDIGENISMO|RODOLFO KUSCH|IDENTIDAD|DISCURSO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89216,"idioma_id":4,"titulo":"Scientific evidence of three different insecticide-resistant profiles in Triatoma infestans (Hemiptera: Reduviidae) populations from Argentina and Bolivia","resumen":"(1)=Estos autores contribuyeron igualmente en este trabajo.    ABSTRACT:  Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae) is the main vector of Chagas disease in the southern cone South America. Chemical control to the vectors appears to be the best option to reduce the incidence of the disease. However, since 2002, high resistance to insecticides that correlated with field control failures was detected in T. infestans from Argentina and Bolivia. In this paper, we analyzed three T. infestans populations whose pyrethroid-resistance had been recently detected, and we defined at least three resistant proÞles according to the toxicological and biochemical characteristics of the studied resistant populations. The resistance profiles were identified as Ti-R1, Ti-R2, and Ti-R3, corresponding to the Argentinean Acambuco, and the Bolivians Entre Ríos and Mataral. Ti-R1 exhibited nymphs and eggs with medium resistance level to deltamethrin (RR  32.5 and 28.6; respectively). Pyrethroid-esterases played a relevant role in deltamethrin resistance. Ti-R2 exhibited nymphs with high resistance to deltamethrin (RR  173.8) and low resistance to fipronil (RR  12.4). Pyrethroid-esterases were involved in resistance. Moreover, eggs showed medium resistance level to deltamethrin (RR  39.1). Ti-R3 had nymphs with low resistance to deltamethrin (RR  17.4), and medium resistance to fipronil (RR  66.8). Pyrethroid-esterases showed increased activity, and eggs possessed low resistance to deltamethrin (RR  8.4). The characterization of the resistance to pyrethroid in these T. infestans populations from Argentina and Bolivia do not permit the generalization of three forms of resistance profile. So far as we appear to know, the forms of mechanisms and their frequencies reported here are selected independently, so additional sites might well show additional combinations of resistance mechanisms and their frequencies.","palabras_clave":"Triatoma infestans,|insecticide resistance|toxicological profile|Chagas disease vector"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89217,"idioma_id":4,"titulo":"Tectono-sequence stratigraphy and U-Pb zircon ages of the Rincón Blanco depocenter, northern Cuyo rift, Argentina","resumen":"Extensional processes that followed the Gondwanan Orogeny rise to the development of a series of rift basins  along the continental margin over older accreted Eopaleozoic terranes. Stratigraphic, structural, paleontological,  and isotopic studies are presented in this work in order to constrain the ages of the sedimentary  infilling and to analyze the tectosedimentary evolution of one of the Cuyo basin depocenters, known as Rincón  Blanco. This asymmetrical half-graben was filled by continental sediments under a strong tectonic control.  The infilling was strongly controlled by tectonics which in term produced distinctive features along the whole  sedimentary sequence. Using a combination of lithological and structural data the infilling was subdivided  into packages of genetically linked units bounded by regional extended surfaces. Several tuffs and acid  volcanic rocks have been collected across the whole section of the Rincon Blanco sub-basin for SHRIMP and  LA-MC-ICPMS U\u2013Pb zircon dating. The ages obtained range from 246.4±1.1 Ma to 230.3±1.5 Ma which is  the time elapsed for the deposition of three tectono-sequence units separated by regional unconformities and  mainly constrained to the Middle Triassic. They are interpreted as a result of a reactivation of the extensional  system that has evolved along strike as segments of faults that linked together and\/or as laterally propagating  faults. Regional correlation with coeval rift basins permits to establish north-south propagation in the  extensional regime along the western margin of SW Gondwana. This trending started in the lowermost  Triassic and extended until the latest Triassic. Two of them were precisely correlated with Cerro Puntudo and  Cacheuta half-graben systems. The new data indicate that the three sequences were mostly deposited during  the Middle Triassic (246 to 230 Ma), with no evidence of sedimentation during Norian and Rhaetian, which is  in conflict with some previous biostratigraphic studies.","palabras_clave":"RINCÓN BLANCO|MENDOZA PROVINCE|SHRIMP DATING|TRISSIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89218,"idioma_id":4,"titulo":"SILICIFICATION OF THE ADAXIAL EPIDERMIS OF LEAVES OF A PANICOID GRASS IN RELATION TO LEAF POSITION AND SECTION AND ENVIRONMENTAL CONDITIONS","resumen":"Many studies relate silica content in plants with internal or external factors; however, few works analyse the effect of these factors on the silicification of different cell types. In this study, we examined the effect of leaf section and leaf position, and environmental conditions on the percentages of silicified epidermal cells of a native Pampean panicoid grass, Bothriochloa laguroides D. C. Pilger. Two different environmental situations were selected for the collection of plants: a natural wetland and a quartzite quarry, located in the southeast Buenos Aires province, Argentina. Clarification and staining methodologies were applied so as to study the distribution of silicified cells in different sections of leaves of the plants collected. Two and three-factor anovas were applied to the data. Between 13% and 19% of total cells of the adaxial epidermis of leaf blades were silicified. Typical silica short cells were the largest contributor to total silicified cells (53?98%), while the second largest contributor was bulliform cells (0?30%). Percentages of total silicified cells were higher in superior than in inferior leaves, while values from leaf sections varied. When collection sites were compared, plants growing in Los Padres pond, where the silica content in soils is higher, had the higher percentage of silicified cells. Among all types of cell, bulliform cells showed differences in the proportion of silicified cells between leaf position and section and collection site. These results show that silica availability in soils is an important factor that conditions silica accumulation and overlaps with the transpiration effect.","palabras_clave":"BOTHRIOCHLOA LAGUROIDES|BULLIFORM CELLS|PAMPEAN GRASS|PHYTOLITHS|QUARRIES|SOIL SILICA CONTENT|WETLAND"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89219,"idioma_id":4,"titulo":"First report of phytoliths in the air of Argentina","resumen":"A first analysis of airborne phytoliths wascarried out in Mar del Plata, Argentina. Its primaryaims were to characterize the phytolith morphotypespresent in the atmosphere, to quantify their abundanceand to detect whether seasonal variations existthroughout the year. The standard method was usedfor monitoring airborne particulate matter applying aHirst-type suction bioaerosol sampler. The meandaily phytoliths concentrations (p\/m3) were calculatedfor eight selected days from the driest year,1993, bearing in mind that its atmospheric conditionscould favour the presence of biomineralizations in theair. The amount of phytoliths reached was of 1,543. Itwas composed of 61% isolated and 1% articulatedtypes. The rest were unknown or unidentified phytoliths(38%). The most abundant morphotypes (72.1%of those identified) were elongates, followed byrondels (16.1%) already described for Poaceae subfamilies,such as Pooideae and Stipoideae. Finally,trapeziform and point shaped were identified with 3.8and 3.4%, respectively. A lower abundance of silicaparticles was detected on high wind speed days fromthe south (sea coast) and under wetter conditions.Maximum phytoliths concentrations were recorded inwinter when pasture burning is carried out alongsideploughing; this also coincides with the period inwhich soils were not covered by vegetation. Theseresults shed light on the importance of consideringthe potential ways of phytoliths dispersion and thefactors that could be affecting their aerial transport,especially when they are applied to the interpretationof paleovegetation from phytolith fossil records.","palabras_clave":"AIRBORNE PHYTOLITHS|DIVERSITY AND SEASONALITY|PAMPEAN PLAINS|AGRICULTURAL PRACTICES|ATMOSPHERIC CONDITIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89220,"idioma_id":4,"titulo":"Problem solving and video games: the Sim City Creator case","resumen":"Video games have proven to be a valuable resource to work different school subjects and topics. Beyond specific content, they could help to develop different abilities, like problem solving. However, not much has been studied on this topic, or many of the studies followed a perspective not entirely compatible with an educational approach. Based on the theory of information processing we analyse the problem-solving processes presented in a classroom when the commercial game Sim City Creator was introduced. The data come from an ethnographic study conducted in a secondary school in Madrid, with students of 3 º ESO, where Sim City Creator was used in Socio-Linguistic Area. Qualitative approach and case study perspective along with discourse analysis was the frame for the data analysis. When students are faced with the problems of the game, they build representations. To do so, they identify the necessary operators, located in the game menu, also considering  the conditions exposed by them, the teacher or the game play, which narrow the problem space. Also, in order to solve the problems students use different strategies, among which we highlight the use of previous schemes and the establishment of subgoals. Commercial video games used in educational settings can become  valuable resources to develop problem-solving processes. The support of teachers and their knowledge of the game are a valuable asset when it comes to take advantage of the game, favouring the construction of representations of the different problems that appear during the game.","palabras_clave":"PROBLEM SOLVING|VIDEO GAMES|SECONDARY SCHOOL|NEW TECHNOLOGIES IN EDUCATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89221,"idioma_id":4,"titulo":"Impaired cardiac mitochondrial function and contractile reserve following an acute exposure to environmental particulate matter","resumen":"DOI: 10.1016\/j.bbagen.2012.11.012Background  It has been suggested that mitochondrial function plays a   central role in cardiovascular diseases associated with particulate   matter inhalation. The aim of this study was to evaluate this   hypothesis, with focus on cardiac O2 and energetic metabolism, and its   impact over cardiac contractility.  Methods  Swiss mice were   intranasally instilled with either Residual Oil Fly Ash (ROFA) (1.0   mg\/kg body weight)or saline solution. After 1, 3 or 5 h of exposure, O2   consumption was evaluated in heart tissue samples.  Mitochondrial   respiration, respiratory chain complexes activity, membrane potential   and ATP content and production rate were assessed in isolated   mitochondria. Cardiac contractile reserve was evaluated according to the   Langendorff technique.  Results  Three hours after ROFA exposure,   tissue O2 consumption was significantly decreased by 35% (from 1180±70   to 760±60 ng-at O\/min g tissue), as well as mitochondrial rest (state 4)   and active (state 3) respiration, by 30 and 24%, respectively (control   state 4: 88±5 ng-at O\/min mg protein; state 3: 240±20 ng-at O\/min mg   protein). These findings were associated with decreased complex II   activity, mitochondrial depolarization and deficient ATP production.   Even though basal contractility was not  modified (control: 75±5 mmHg),   isolated perfused hearts failed to properly respond to isoproterenol in   ROFA-exposed mice. Tissue O2 consumption rates positively correlated   with cardiac contractile state  in controls (r2=0.8271), but not in   treated mice (r2=0.1396).  Conclusion and general significance The   present results show an impaired mitochondrial function associated with   deficient cardiac contractility, which could represent an early   cardiovascular alteration after the exposure to environmental   particulate matter.  ","palabras_clave":"Heart|Mitochondria|Contractile reserve|Particulate matter"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89222,"idioma_id":5,"titulo":"CONTRIBUCIONES AL CONOCIMIENTO DEL ESTADO ACTUAL DE LA MIELOPATIA DEGENERATIVA","resumen":"Escribo esto en relación al artículo \u201CMielopatía degenerativa en caninos raza boxer: aproximación diagnóstica y manejo terapéutico\u201D, publicado en la Revista Veterinaria Argentina (volumen XXIX No.285). Es mi intención realizar algunos aportes en relación al estado actual del conocimiento del tema de esta patología devastadora de algunas razas de perros, en virtud de los avances de la medicina veterinaria, particularmente en lo que se refiere al diagnóstico de enfermedades genéticas.","palabras_clave":"Mielopatía Degenerativa|Actualización"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89223,"idioma_id":4,"titulo":"Numerical Solution of the Variational PDEs Arising in Optimal Control Theory","resumen":"An iterative method based on Picard\u2019s approachto ODEs\u2019 initial-value problems is proposed to solve first-orderquasilinear PDEs with matrix-valued unknowns, in particular,the recently discovered variational PDEs for the missing boundaryvalues in Hamilton equations of optimal control. As illustrationsthe iterative numerical solutions are checked against theanalytical solutions to some examples arising from optimal controlproblems for nonlinear systems and regular Lagrangians infinite dimension, and against the numerical solution obtainedthrough standard mathematical software. An application tothe (n + 1)-dimensional variational PDEs associated with then-dimensional finite-horizon time-variant linear-quadratic problemis discussed, due to the key role the LQR plays in twodegrees-of freedom control strategies for nonlinear systems withgeneralized costs.","palabras_clave":"NUMERICAL METHODS|FIRST ORDER PDES|NONLINEAR SYSTEMS|OPTIMAL CONTROL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89224,"idioma_id":4,"titulo":"Predicting the environmental niche of the genus Phymaturus: Are palluma and patagonicus groups ecologically differentiated?","resumen":"The genus Phymaturus (Reptilia: Liolaemidae) is distributed in the mountains and rocky plateaux of Argentina and Chile and comprises two groups of species, palluma and patagonicus.The two lineages have diverged early in the evolution of the genus and up to today, there is very little geographical overlap between them.We worked with records of localities from the literature, herpetological collections and &#64257;eld data to evaluate habitat suitability of the genus Phymaturus. We used 11 environmental variables to develop environmental niche models (ENMs) for each group within the genus using the Maxent software, and to determine those variables that best explain the distribution of each group.We also estimated measures of niche similarity using ENMTools to determine whether niche differentiation is real or apparent.The geographical overlap between the groups was very low considering the large geographical range of the genus. Some variables, such as mean annual temperature, soil type and bare soil cover, have a high contribution to the models for both groups. The current niche overlap between Phymaturus groups indicates that the environmental niches of the palluma and patagonicus groups are not equivalent. Based on background analysis, we cannot reject the hypothesis that similarity (or divergence) between groups of Phymaturus is no more than expected based on the availability of habitat. The results of this study are a &#64257;rst approximation to the knowledge of the environmental variables associated with the palluma and patagonicus groups, and reveal that the ecological differences found between these groups are more likely due to habitat availability in their respective regions than to differences in habitat preferences.","palabras_clave":"ENVIRONMENTAL NICHE MODEL|LIZARDS|NICHE SIMILARITY|PHYMATURUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89225,"idioma_id":5,"titulo":". Petrología del complejo volcánico Barril Niyeu (Mioceno inferior), Patagonia Argentina","resumen":"El plateau volcánico oligoceno de Somún Curá, en el norte de la Patagonia extraandina de Argentina, está compuesto principalmente por basaltos afíricos de olivino, alcalinos a transicionales, que cubren un área de ~25,000 km2. Se distinguen varios eventos post-plateau del Mioceno que originaron grandes centros bimodales y volúmenes menores provenientes de volcanes monogenéticos. Uno de los complejos post-plateau más grandes es el Complejo Volcánico Barril Niyeu (CVBN), conformado por una secuencia de rocas lávicas y piroclásticas asociadas a por lo menos cinco calderas de varios kilómetros de diámetro. Dataciones K\/Ar sobre roca total (20.6±0.4 Ma y 18.7±0.4 Ma) acotan la actividad del CVBN al Mioceno temprano. La facies lávica y piroclástica de traquitas predomina en la base de la secuencia y las composiciones basálticas en la parte superior. La facies piroclástica está integrada por flujos piroclásticos y depósitos de caída de composición ácida y depósitos de tipo estromboliano subordinados. Toda la serie tiene tendencia alcalina y presenta un gap composicional de 52 a 67% SiO2. Los datos geoquímicos e isotópicos (Sr, Nd) indican que las rocas del CVBN están relacionadas genéticamente por procesos cristal-líquido, esencialmente de fusión parcial y cristalización fraccionada. Según el modelado geoquímico, el basalto más primitivo de la serie (Mg# = 66; Ni = 160 ppm; Cr = 290 ppm) habría derivado de la fusión parcial (8\u201310%) de una fuente peridotítica granatífera. Las interrelaciones de elementos de alto potencial iónico (Th\/Yb, Ta\/Yb) indican un ambiente de intraplaca, y las relaciones LILE\/REE (Ba\/La) una contribución subordinada de componentes de zona de subducción. Las relaciones Rb\/Nb y las concentraciones de Th en algunos basaltos podrían ser el resultado de asimilación de rocas corticales. En general, la composición isotópica de los basaltos sugiere una fuente mantélica empobrecida (DM) con contribuciones subordinadas de manto enriquecido de tipo 1 (EM1). El magmatismo oligo-mioceno de Somún Curá es atribuido a un proceso de delaminación litosférica disparado por perturbaciones gravitacionales durante la reorganización de placas en el borde Pacífico de la placa Sudamericana, con contribución subordinada de una placa oceánica desprendida (Aluk?).","palabras_clave":"vulcanismo bimodal, .|Mioceno|Barril Niyeu|Patagonia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89226,"idioma_id":4,"titulo":"Changes in micro RNA expression in a wild tuber-bearing Solanum species induced by 5-Azacytidine treatment","resumen":"Phenotypic plasticity is often postulated as a principal characteristic of tuber-bearing wild Solanum species. The hypotheses to explore this observation have been developed based on the presence of genetic variation. In this context, evolutionary changes and adaptation are impossible without genetic variation. However, epigenetic effects, which include DNA methylation and microRNAs expression control, could be another source of phenotypic variation in ecologically relevant traits. To achieve a detailed mechanistic understanding of these processes, it is necessary to separate epigenetic from DNA sequence-based effects and to evaluate their relative importance on phenotypic variability. We explored the potential relevance of epigenetic effects in individuals with the same genotype. For this purpose, a clone of the wild potato Solanum ruiz-lealii, a non-model species in which natural methylation variability has been demonstrated, was selected and its DNA methylation was manipulated applying 5-Azacytidine (AzaC), a demethylating agent. The AzaC treatment induced early flowering and changes in leaf morphology. Using quantitative real-time PCR, we identified four miRNAs up-regulated in the AzaC-treated plants. One of them, miRNA172, could play a role on the early flowering phenotype. In this work, we showed that the treatment with AzaC could provide meaningful results allowing to study both the phenotypic plasticity in tuber-bearing Solanum species and the inter-relation between DNA methylation and miRNA accumulations in a wide range of species.","palabras_clave":"DNA METHYLATION| EPIGENETICS| MICRO RNAs| PHENOTYPIC PLASTICITY| WILD POTATO SPECIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89227,"idioma_id":4,"titulo":"High-pressure liquid-liquid equilibrium boundaries  for systems containing polybutadiene and\/or polyethylene and a light solvent or solvent mixture","resumen":"In this work, we have obtained experimental cloud points, i.e., liquid\u2013liquid equilibrium boundariesat constant composition, for the systems \u2018polybutadiene (PB) + n-pentane (C5)\u2019, \u2018PB + dimethyl ether(DME) + C5\u2019, \u2018polyethylene (PE) + DME + C5\u2019, and \u2018PB + PE + DME + C5\u2019. The temperature range of the experimentswas from 50 to 184 &#9702;C. The maximum pressure was 303 bar. In all cases the overall polymerconcentration was less than or equal to 4.1 wt%. At the ranges of conditions of the experiments we havefound the following: (a) For PB + C5, the minimum pressure required to guarantee homogeneity is 140 bar.(b) For \u2018PB + C5 + DME\u2019, the cloud point pressure (CPP) curves lie in between the CPP curves of \u2018PB + DME\u2019and \u2018PB + C5\u2019, and the maximum CPP was 226 bar. The CPP increases with the increase of the DME\/C5ratio in the solvent mixture. (c) For \u2018PE + DME + C5\u2019, there is a substantial decrease in the CPPs with theaddition of C5 to the DME + C5 solvent mixture, and the maximum CPP was 303 bar. (d) The CPPs for\u2018PB + PE + DME + C5\u2019 are higher than the CPPs of \u2018PB + DME + C5\u2019 but lower than the CPPs of \u2018PE + DME + C5\u2019.","palabras_clave":"POLYETHYLENE|MIXTURES|PHASE EQUILIBRIUM|HIGH PRESSURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89228,"idioma_id":5,"titulo":"Explotación de recursos vegetales silvestres y domesticados en Neuquén: implicancias del hallazgo de restos de maiz y algarrobo en artefactos de molienda del holoceno tardío.","resumen":"En este trabajo se presentan los resultados obtenidos del análisis de artefactos de molienda recuperados de los sitios Aquihuecó (3700 AP) y Michacheo (1860 AP) en la provincia de Neuquén. Dichos análisis consistieron en la identificación de microrrestos vegetales adheridos a sus superficies. Los resultados obtenidos evidencian el procesamiento de frutos de Prosopis sp en ambos sitios y de granos de Zea mays en Michacheo. Este ultimo sitio cuenta además con restos de cerámica, por lo cual hacia el 2000 AP habría una ampliación de la base tecnológica y de recursos alimenticios. El análisis de los contextos arqueológicos evidencian la asociación entre estos artefactos de molienda y el entierro de mujeres adultas a lo largo del Holoceno tardío. La evidencia bioantropológica asociada señala un aumento en la presencia de caries y una disminución del desgaste dental a partir de los 2000 AP, lo cual se asociaría a la incorporación de nuevos recursos y tecnología, si bien los análisis de isótopos estables señalan la ausencia de dietas enriquecidas por el consumo de plantas C4 como el maíz.","palabras_clave":"maíz|Norpatagonia|molienda|Prosopis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89229,"idioma_id":4,"titulo":"The invasion of Patagonia by Chinook salmon ( Oncorhynchus tshawytscha ): inferences from mitochondrial DNA patterns","resumen":"The Chinook salmon Oncorhynchus tshawytscha, which was introduced deliberately in Chile four decades ago for sport fishing and aquaculture, represents a rare example of a successful translocation of an anadromous Pacific salmon into the southern Hemisphere, offering an unique opportunity to examine the role of introduction history and genetic variability in invasion success. We used historical information and mitochondrial displacement loop sequences (D-loop) from seven colonized sites in Chile and Argentina and from native and naturalized Chinook salmon populations to determine population sources and to examine levels of genetic diversity associated with the invasion. The analysis revealed that the Chinook salmon invasion in Patagonia originated from multiple population sources from northwestern North America and New Zealand, and admixed in the invaded range generating genetically diverse populations. Genetic analyses further indicated that the colonization of new populations ahead of the invasion front appear to have occurred by noncontiguous dispersal. Dispersal patterns coincided with ocean circulation patterns dominated by the West Wind Drift and the Cape Horn Currents. We conclude that admixture following multiple introductions, as well as long-distance dispersal events may have facilitated the successful invasion and rapid dispersal of Chinook salmon into Patagonia.","palabras_clave":"human-mediated invasions|multiple introductions|admixture|long-distance dispersal"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89230,"idioma_id":4,"titulo":"No evidence of extra-pair paternity or intraspecific brood parasitism in the Imperial Shag Phalacrocorax atriceps","resumen":"In long-lived birds with significant paternal care contribution, as the case of seabirds, extra-pair paternity (EPP) is an infrequent phenomenon. Intriguingly, and in contrast to the general pattern exhibited by seabirds, EPP rates appear relatively high in the two species of cormorants and shags (Phalacrocoracidae family) analyzed so far. We test for EPP in the Imperial Shag Phalacrocorax atriceps, a medium-sized colonial seabird, using four DNA microsatellites originally developed for Great Cormorants P. carbo, and successfully cross-amplified in our focal species. We assessed the parentage of 110 chicks from 37 broods sampled at Punta Leo´n, Argentina, during the 2004 and 2005 breeding seasons. We found no evidence of EPP or intraspecific brood parasitism (IBP). Given our sample sizes, the upper 95% confidence limits for both EPP and IBP were estimated at 3.3% for the chicks and 8.4% for the broods. Our results did not agree with the previous reports of EPP within the family, probably as consequence of different copulation and courtship behaviours, mostly related to male\u2019s solicitation display and females active search for extra pair copulations.","palabras_clave":"CORMORANTS|GENETIC PARENTS|MICROSATELLITES|PHALACROCORACIDAE|SEABIRDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89231,"idioma_id":4,"titulo":"How much is too much? Assessment of prey consumption by Magellanic penguins in Patagonian colonies","resumen":"Penguins are major consumers in the southern oceans although quantification of this has been problematic. One suggestion proposes the use of points of inflection in diving profiles (´wiggles´) for this, a method that has been validated for the estimation of prey consumption by Magellanic penguins (Spheniscus magellanicus) by Simeone and Wilson (2003). Following them, we used wiggles from 31 depth logger-equipped Magellanic penguins foraging from four Patagonian colonies; Punta Norte (PN), Bahía Bustamente (BB), Puerto Deseado (PD) and Puerto San Julián (PSJ), all located in Argentina between 42-49° S, to estimate the prey captured and calculate the catch per unit time (CPUT) for birds foraging during the early chick-rearing period. Numbers of prey caught and CPUT were significantly different between colonies. Birds from PD caught the highest number of prey per foraging trip, with CPUT values of 68 ± 19 prey per hour underwater (almost two times greater than for the three remaining colonies). We modeled consumption from these data and calculate that the world Magellanic penguin population consumes about 2 million tons of prey per year. Possible errors in this calculation are discussed. Despite this, the analysis of wiggles seems a powerful and simple tool to begin to quantify prey consumption by Magellanic penguins, allowing comparison between different breeding sites. The total number of wiggles and\/or CPUT do not reflect, by themselves, the availability of food for each colony, as the number of prey consumed by foraging trip is strongly associated with the energy content and wet mass of each colony-specific ´prey type´. Individuals consuming more profitable prey could be optimizing the time spent underwater, thereby optimizing the energy expenditure associated with the dives.","palabras_clave":"PREY CONSUMPTION|FORAGING SUCCES|FORAGING EFFORT|MAGELLANIC PENGUIN|SPHENISCUS MAGELLANICUS|PATAGONIA|CONSERVATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89232,"idioma_id":4,"titulo":"Foraging effort in Magellanic penguins in coastal Patagonia, Argentina","resumen":"In long-lived species such as seabirds, foraging success is considered to be related to breeding success, so quantification of foraging parameters during the breeding season should help understand population trends. Using GPS units, we studied the foraging effort of 55 breeding Magellanic penguins Spheniscus magellanicus from 5 colonies in coastal Patagonia, Argentina (42 to 54°S): Punta Norte, Bahía Bustamante, Puerto Deseado, Puerto San Julián and Isla Martillo, in an attempt to relate this to differences in breeding population trends. Measures of foraging effort\u2014trip duration, total distance covered and maximun distance of the foraging trips from the breeding colony\u2014decreased with increasing rate of population change. This information suggests that there are large differences in foraging effort and success among Patagonian penguin colonies, and penguins from Bahía Bustamante and Puerto Deseado, which are in the centre of the geographic range, require the highest foraging effort but are the least successful. It is plausible that lower population growth rates in these 2 colonies stem from the differences in food availability rather than any other process on land.","palabras_clave":"MAGELLANIC PENGUIN|SPHENISCUS MAGELLANICUS|FORAGING EFFORT|POPULATION TRENDS|GPS TRACKING|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89233,"idioma_id":5,"titulo":". Mixobiota del departamento Chilecito (La Rioja Argentina)","resumen":"Se citan por primera vez para la región de Cuyo los géneros Hemitrichia y Ceratiomyxa, así como también a Arcyria oerstedii. Se amplia el área de distribución de Physarum pusillum para la provincia de La Rioja. Se describen los esporangios, incluyendo dibujos y fotografías. Se incluye una clave dicotómica de las especies citadas para el departamento Chilecito.","palabras_clave":"Myxomycetes|, Protista|Taxonomía, |La Rioja"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89234,"idioma_id":4,"titulo":"Conditional Wwox deletion in Mouse Mammary Gland by Means of Two Cre Recombinase Approaches","resumen":"Loss of WWOX   expression has been reported in many different cancers including breast   cancer. Elucidating the function of this gene in adult tissues has not   been possible with full Wwox knockout models. Here we characterize the first conditional models of Wwox ablation in mouse mammary epithelium utilizing two transgenic lines expressing Cre recombinase, keratin 5-Cre (BK5-Cre) and MMTV-Cre. In the BK5-Cre model we observed very efficient Wwox ablation in KO mammary glands. However, BK5-Cre Wwox KO animals die prematurely for unknown reasons. In the MMTV-Cre model we observed significant ablation of Wwox in mammary epithelium with no effect on survival. In both of these models we found that Wwox deletion resulted in impaired mammary branching morphogenesis. We demonstrate that loss of Wwox   is not carcinogenic in our KO models. Furthermore, no evidence of   increase proliferation or development of premalignant lesions was   observed. In none of the models did loss of a single Wwox allele (i.e. haploinsufficiency) have any observable phenotypic effect in mammary gland. To better understand the function of Wwox in the mammary gland, transcriptome profiling was performed. We observed that Wwox   ablation results in the deregulation of genes involved in various   cellular processes. We found that expression of the non-canonical Wnt   ligand, Wnt5a, was significantly upregulated in Wwox KO mammary   epithelium. Interestingly, we also determined that components of the   Jak\/Stat3 signaling pathway were upregulated in KO mice and this   correlated with a very robust increase in phospho-Stat3 signaling, which   warrants further testing. Even though the loss of Wwox expression in breast and other cancers is very well documented, our findings suggest that Wwox does not act as a classical tumor suppressor as previously thought","palabras_clave":"WWOX|MOUSE|MAMMARY|GLAND"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89235,"idioma_id":4,"titulo":"Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein","resumen":"Tristetraprolin (TTP) is a RNA-binding protein that  inhibits the expression of pro-inflammatory cytokines and invasiveness-associated  genes. TTP levels are decreased in many different cancer types and it has been proposed  that this protein could be used as a prognostic factor in breast cancer. Here,  using publicly available DNA microarray datasets, 'erial analysis of gene  expression' libraries and qRT-PCR analysis, we determined that TTP mRNA is  present in normal breast cells and its levels are significantly decreased in  all breast cancer subtypes. In addition, by immunostaining, we found that TTP  expression is higher in normal breast tissue and benign lesions than in  infiltrating carcinomas. Among these, lower grade tumors showed increased TTP  expression compared to higher grade cancers. Therefore, these data indicate  that TTP protein levels would provide a better negative correlation with breast  cancer invasiveness than TTP transcript levels. In mice, we found that TTPmRNA  and protein expression is also diminished in mammary tumors. Interestingly, a  strong positive association of TTP expression and mammary differentiation was  identified in normal and tumor cells. In fact, TTP expression is highly  increased during lactation, showing good correlation with various mammary  differentiation factors. TTP expression was also induced in mammary HC11 cells  treated with lactogenic hormones, mainly by prolactin, through Stat5A  activation. The effect of this hormone was highly dependent on mammary  differentiation status, as prolactin was unable to elicit a similar response in  proliferating or neoplastic mammary cells. In summary, these studies show that  TTP expression is strongly linked to the mammary differentiation program in  human and mice, suggesting that this protein might play specific and relevant  roles in the normal physiology of the gland","palabras_clave":"TTP|BREAST|CANCER|EXPRESSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89236,"idioma_id":4,"titulo":"RHBDD2: a 5-fluorouracil responsive gene overexpressed in the advanced stages of colorectal cancer","resumen":"In previous studies, we identified rhomboid domain containing 2 (RHBDD2) gene to be markedly overexpressed in breast cancer patients that developed recurrence of the disease. In this study, we evaluated for the first time RHBDD2 gene expression in colorectal cancer (CRC). Five public available DNA microarray studies were compiled in a homogeneous dataset of 906 colorectal samples. The statistical analysis of these data showed a significant increase of RHBDD2 expression in the advanced stages of CRC (p < 0.01). We validated these findings by immunohistochemistry on 130 colorectal tissue samples; RHBDD2 protein overexpression was also observed in the advanced stages of the disease (p < 0.001). In addition, we investigated RHBDD2 expression in response to the chemotherapy agent 5-fluorouracile (5FU). We detected a significant increase of RHBDD2 mRNA and protein after 5FU treatment (20-40 &#956;M; p < 0.001). Overall, these results showed that RHBDD2 overexpression might play a role in colorectal cancer progression.","palabras_clave":"COLORECTAL CANCER|TUMOR MARKER|RHBDD2|5FU"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89237,"idioma_id":4,"titulo":"Brucella invasion of human intestinal epithelial cells elicits a weak proinflammatory response but a significant CCL20 secretion","resumen":"In spite of the frequent acquisition of Brucella infection by the oral route in humans, the interaction of the bacterium with cells of the intestinal mucosa has been poorly studied. Here, we show that different Brucella species can invade human colonic epithelial cell lines (Caco-2 and HT-29), in which only smooth species can replicate efficiently. Infection with smooth strains did not produce a significant cytotoxicity, while the rough strain RB51 was more cytotoxic. Infection of Caco-2 cells or HT-29 cells with either smooth or rough strains of Brucella did not result in an increased secretion of TNF-alpha, IL-1beta, MCP-1, IL-10 or TGF-beta as compared with uninfected controls, whereas all the infections induced the secretion of IL-8 and CCL20 by both cell types. The MCP-1 response to flagellin from Salmonella typhimurium was similar in Brucella-infected or uninfected cells, ruling out a bacterial inhibitory mechanism as a reason for the weak proinflammatory response. Infection did not modify ICAM-1 expression levels in Caco-2 cells, but increased them in HT-29 cells. These results suggest that Brucella induces only a weak proinflammatory response in gut epithelial cells, but produces a significant CCL20 secretion. The latter may be important for bacterial dissemination given the known ability of Brucella to survive in dendritic cells.","palabras_clave":"BRUCELLA|GUT EPITHELIAL CELLS|INTRACELLULAR REPLICATION|INFLAMMATORY RESPONSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89238,"idioma_id":4,"titulo":"Provisional dichotomic keys for the genera and species of Xylariaceae (Ascomycota) from Tucumán, ARGENTINA","resumen":"Sir, E. B.; T. C. Perera; A. I. Romero; A. I. Hladki. 2012. Provisional dichotomic keys for the genera and species of Xylariaceae (Ascomycota) from Tucumán, Argentina. Lilloa  49 (1). Dichotomous keys to eleven genera and fortynine species based primarily on collections from Las Yungas in Tucuman province, Argentina are presented. The number of each species per genus is presented and expressed graphically in percentages.   Keywords:Hypoxyloid species,  Kretzschmaria, Rosellinia, Stilbohypoxylon, Xylaria.","palabras_clave":"HYPOXYLOID SPECIES|KRETZSCHMARIA|ROSELLINIA|STILBOHYPOXYLON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89239,"idioma_id":4,"titulo":"Fe\/MnAs bilayers: Magnetic anisotropy and the role of the interface","resumen":"We have studied different aspects of the magnetic behavior of Fe(5   nm)\/MnAs(100 nm) bilayers epitaxially grown on GaAs(1 0 0).   Ferromagnetic resonance (FMR) measurements were performed in order to   characterize the magnetic anisotropies of the films and the interlayer   coupling between them. The chemical composition of the interface was   investigated by X-ray photoemission spectroscopy (XPS). The iron layer   FMR spectrum is highly temperature dependent between 280 K and 320 K as   its parameters are strongly altered in the alpha\/beta phase coexistence regime   of the MnAs layer, revealing a strong interlayer coupling in this   T-region. Additionally, the XPS experiments demonstrate the existence of   an Fe-MnAs intermixed interface. This result would explain the   appearance of an additional uniaxial anisotropy in the plane of the Fe   films, together with a strong reduction in its magnetocrystalline   anisotropy and a negligible direct exchange coupling in the MnAs   ferromagnetic state.","palabras_clave":"bilayers|interfaces|manganese arsenide|spintronics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89240,"idioma_id":4,"titulo":"Magnetic structure of hydrogen-induced defects on graphene","resumen":"Using density-functional-theory (DFT), Hartree-Fock, exact-diagonalization, and numerical-renormalization-group methods, we study the electronic structure of diluted hydrogen atoms chemisorbed on graphene. A comparison between DFT and Hartree-Fock calculations allows us to identify the main characteristics of the magnetic structure of the defect. We use this information to formulate an Anderson-Hubbard model that captures the main physical ingredients of the system while still allowing a rigorous treatment of the electronic correlations. We find that the large hydrogen-carbon hybridization puts the structure of the defect halfway between the one corresponding to an adatom weakly coupled to pristine graphene and that of a carbon vacancy. The impurity's magnetic moment leaks into the graphene layer where the electronic correlations on the C atoms play an important role in stabilizing the magnetic solution. Finally, we discuss the implications for the Kondo effect.","palabras_clave":"hydrogen|Graphene|magnetism|LDA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89241,"idioma_id":4,"titulo":"Tunable Charge and Spin Seebeck Effects in Magnetic Molecular Junctions","resumen":"We study the charge and spin Seebeck effects in a spin-1 molecular junction as a function of temperature, applied magnetic field, and magnetic anisotropy (D) using Wilson´s numerical renormalization group. A hard-axis magnetic anisotropy produces a large enhancement of the charge Seebeck coefficient Sc (&#8764;kB\/|e|) whose value only depends on the residual interaction between quasiparticles in the low-temperature Fermi-liquid regime. In the underscreened spin-1 Kondo regime, the high sensitivity of the system to magnetic fields makes it possible to observe a sizable value for the spin Seebeck coefficient even for magnetic fields much smaller than the Kondo temperature. Similar effects can be obtained in C60 junctions where the control parameter, instead of D, is the gap between a singlet and a triplet molecular state.","palabras_clave":"KONDO|MOLECULAR|THERMOPOWER|SEEBECK"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89242,"idioma_id":4,"titulo":"Thermopower of an SU(4) Kondo resonance under an SU(2) symmetry-breaking field","resumen":"We calculate the thermopower of a quantum dot described by two doublets hybridized with two degenerate bands of two conducting leads, conserving orbital (band) and spin quantum numbers, as a function of the temperature T and a splitting &#948; of the quantum dot levels that breaks the SU(4) symmetry. The splitting can be regarded as a Zeeman (spin) or valley (orbital) splitting. We use the noncrossing approximation (NCA), the slave bosons in the mean-field approximation (SBMFA), and also the numerical renormalization group (NRG) for large &#948;. The model describes transport through clean C nanotubes and in Si fin-type field-effect transistors, under an applied magnetic field. The thermopower as a function of temperature S(T) displays two dips that correspond to the energy scales given by the Kondo temperature TK and &#948; and one peak when kBT reaches the charge-transfer energy. These features are much more pronounced than the corresponding ones in the conductance, indicating that the thermopower is a more sensitive probe of the electronic structure at intermediate or high energies. At low temperatures (T&#8810;TK), TKS(T)\/T is a constant that increases strongly near the degeneracy point &#948;=0. We find that the SBMFA fails to provide an accurate description of the thermopower for large &#948;. Instead, a combination of Fermi liquid relations with the quantum-dot occupations calculated within the NCA gives reliable results for T&#8810;TK.","palabras_clave":"THERMOPOWER|KONDO|NANOTUBE|SU(4)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89243,"idioma_id":4,"titulo":"Transport through side-coupled double quantum dots: From weak to strong interdot coupling","resumen":"We report low-temperature transport measurements through a double-quantum-dot device in a configuration where one of the quantum dots is coupled directly to the source and drain electrodes, and a second (side-coupled) quantum dot interacts electrostatically and via tunneling to the first one. As the interdot tunneling coupling increases, a crossover from weak to strong interdot tunneling is observed in the charge stability diagrams that present a complex pattern with mergings and apparent crossings of Coulomb blockade peaks. While the weak-coupling regime can be understood by considering a single level on each dot, in the intermediate- and strong-coupling regimes, the multilevel nature of the quantum dots needs to be taken into account. Surprisingly, both in the strong- and weak-coupling regimes, the double-quantum-dot states are mainly localized on each dot for most values of the parameters. Only in an intermediate-coupling regime does the device present a single dotlike molecular behavior as the molecular wave functions weight is evenly distributed between the quantum dots. At temperatures larger than the interdot coupling energy scale, a loss of coherence of the molecular states is observed.","palabras_clave":"electronic transport|quantum dots"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89244,"idioma_id":5,"titulo":"Variación interpoblacional y ontogenética de la dieta de rana llorona Physalaemus albonotatus (Anura: Leiuperidae)","resumen":"Se analizó y comparó el espectro trófico de dos poblaciones de Physalaemus albonotatus que habitan en ecosistemas diferentes: a) un terreno baldío urbano y b) un área protegida del valle aluvial del río Paraná Medio. Physalaemus albonotatus posee una dieta compuesta fundamentalmente de hormigas, coleópteros, colémbolos e isópodos, pero con numerosas presas secundarias. Al comparar tres clases de tamaño dentro de cada población (adultos, subadultos y jóvenes), se encontró una variación ontogenética relacionada con el volumen, cantidad y tipo de presa ingerida. Los anfibios de mayor tamaño consumieron una mayor cantidad de presas y más voluminosas, pero los jóvenes tuvieron una amplitud del nicho trófico mayor. Entre los adultos, la similitud de la dieta entre sexos fue muy elevada, aunque las hembras consumieron una mayor cantidad de hormigas que los machos. Si bien el solapamiento trófico entre las poblaciones fue elevado, la amplitud trófica resultó mayor en la población del humedal fluvial. Las diferencias en la alimentación encontradas entre las dos poblaciones y con otros trabajos realizados en diferentes ambientes reflejan la plasticidad trófica por parte de este anuro, característica que le permite prosperar en hábitats diversos, incluso ampliamente antropizados.","palabras_clave":"Anuros|hábitats de forrajeo|ambiente urbano|humedal fluvial|plasticidad trófica|solapamiento trófico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89245,"idioma_id":5,"titulo":"Especies exoticas y conservacion. El primer registro del hongo quitridio en rana toro (Lithobates catesbeianus) de Argentina","resumen":"La quitridiomicosis, enfermedad emergente producida por el hongo Batrachochytrium dendrobatidis (B.d.), es reconocida como uno de los factores causantes de la declinación global de anfibios. El comercio mundial de este grupo de vertebrados ha sido señalado como una de las fuentes de dispersión de B.d. Muchos trabajos advierten sobre la pre-sencia del hongo vinculada a la compra-venta de ejemplares para mascotismo, ornamentación de estanques, acuicultura, zoológicos y actividades de laboratorio, entre otros. Numerosos estudios demuestran que B.d. infecta asintomáticamente a la rana toro nortemaricana (Lithobates catesbeianus), lo que contribuye con la dispersión de la enfermedad en nuevas áreas geográficas donde este anfibio es introducido. En este trabajo se determinó la presencia de B.d. en la especie exótica rana toro mediante cortes histológicos de nueve ejemplares provenientes de un criadero de la ciudad de Santa Fe (Argentina), depositados y conservados desde 1993 en la Colección Herpetológica del Museo Provincial de Ciencias Naturales ?Florentino Ameghino?. Este registro representa el hallazgo más antiguo de B.d. en Argentina y el primer caso de este hongo en la exótica rana toro en el país; por lo que enfatizamos la importancia de determinar y monitorear la distribución y dispersión de B.d., particularmente en los sitios donde ya se han detectado poblaciones silvestres de rana toro.","palabras_clave":"quitridiomicosis|invasiones biológicas|registros históricos de museo|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89246,"idioma_id":4,"titulo":"Public Policies Addressed to the Social and Solidarity Economy in South America. Toward a New Model?","resumen":"Since the beginning of this century, most South American countries have modified their position within society, challenging the self-regulating nature of markets and intervening in social issues. This approach supports the transition toward a ?third-generation? model for the social policy field, one in which Social and Solidarity Economy (SSE) acquires a relevant role. In the last few years, many public policies have included SSE in their design, with the purpose of addressing the key issues of developing societies: unemployment and poverty. This article analyzes the main regulatory dimensions and conditionings of the national programs that promote SSE in South American countries and aim to enhance social inclusion and employment. Particularly, the article examines the most illustrative social programs implemented at the national level in Argentina, Brazil, Ecuador, Uruguay and Venezuela in the last decade.","palabras_clave":"Social policies|Regulations|Social Economy|South America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89247,"idioma_id":4,"titulo":"Effects of spin density wave quantization on the electrical transport in epitaxial Cr thin films","resumen":"We present measurements of the electrical resistivity &#961; in epitaxial Cr films of different thicknesses grown on MgO (100) substrates, as a function of temperature T . The &#961;(T ) curves display hysteretic behavior in a certain temperature range, which is film thickness dependent. The hysteresis are related to the confinement of quantized incommensurate spin density waves (ISDW) in the film thickness. Our important finding is to experimentally show that the temperature Tmid where the ISDW changes from N to N + 1 nodes decreases as the film thickness increases. Identifying Tmid with a first-order transition between ISDWstates with N and N + 1 nodes, and using a Landau approach to the free energy of the ISDW together with Monte Carlo simulations, we show that the system at high temperatures explores all available modes for the ISDW, freezing out in one particular mode at a transition temperature that indeed decreases with film thickness L. The detailed dependence of Tmid(L) seems to depend rather strongly on the boundary conditions at the Cr film interfaces.","palabras_clave":"CHROMIUM|FILMS|SPIN-DENSITY-WAVES|HYSTERESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89248,"idioma_id":4,"titulo":"Neogene tectonic rotations and margin curvature at the pampean flat slab segment (28°-33°Sl, Argentina)","resumen":"Available paleomagnetic data from the Pampean flat slab segment reveal a heterogeneous rotation pattern that is interpreted herein as the result of the overprinting of late NNW-WNW left-lateral brittle-ductile megashear zones that would be also responsible for the continental margin bending.","palabras_clave":"Paleomagnetism|transpressional and transtensional belts|Precordillera|subduction of aseismic ridges"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89249,"idioma_id":4,"titulo":"EVIDENCE OF REDUCED FEEDING AND OXIDATIVE STRESS IN COMMON TREE FROGS (HYPSIBOAS PULCHELLUS) FROM AN AGROECOSYSTEM EXPERIENCING SEVERE DROUGHT","resumen":"The intensification of modern agriculture may impact amphibian populations through habitat loss and the direct and indirect effects of the pesticides upon which it relies. The increased homogeneity of modern agricultural landscapes may be detrimental in times of extreme low and high temperatures associated with climate change, as refuge abundance and habitat connectivity decrease. In this study, we evaluated the impacts of the herbicide glyphosate and subsequent intense drought on the Common Tree Frog, Hypsiboas pulchellus, inhabiting an agricultural landscape. We examined a series of organismic indices (stomach content index, hepatosomatic index, body fat index, gonadosomatic index, condition factor) as well as biomarkers of oxidative stress (hepatic catalase activity and reduced glutathione [GSH] content), exposure to contaminants (hepatic gluthatione-S-transferase activity), and genotoxicity (frequency of micronuclei). No significant differences were observed in the parameters measured when comparing frogs sampled before, 2, and 15 days after glyphosate exposure. However, anurans sampled in the same site two months later, when a drought was at its peak, presented a decrease in stomach content and hepatosomatic index, as well as an increase in hepatic catalase activity, hepatic GSH content and micronuclei frequency in peripheral circulating erythrocytes. Our findings demonstrate that drought is challenging to these anurans in this environment as evidenced by an apparent reduction in food intake and oxidative stress.","palabras_clave":"agriculture|global warming|amphibian|pesticides"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89250,"idioma_id":4,"titulo":"A consistent total Lagrangian finite element for composite closed section thin walled beams","resumen":"This work presents a consistent geometrically exact finite element formulation of the thin-walled anisotropic beam theory. The present formulation is thought to address problems of composite beams with nonlinear behavior. The constitutive formulation is based on the relations of composite laminates and thus the cross sectional stiffness matrix is obtained analytically. The variational formulation is written in terms of generalized strains, which are parametrized with the director field and its derivatives. The generalized strains and generalized beam forces are obtained by introducing a transformation that maps generalized components into physical components. A consistent tangent stiffness matrix is obtained by parametrizing the finite rotations with the total rotation vector; its derivation is greatly simplified by obtention of the derivatives of the director field via interpolation of nodal triads. Several numerical examples are presented to show the accuracy of the formulation and also its frame invariance and path independence.","palabras_clave":"Composite beams|Finite elements| Finite rotations|Thin-walled beams|Optimization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89251,"idioma_id":5,"titulo":"Implicancia de las prostaglandinas en la fisiopatología de la endometriosis.","resumen":"Las  prostaglandinas (PGs), los tromboxanos (TXs) y los leukotrienos (LTs)  denominados en forma colectiva eicosanoides, son productos de ciclooxigenasas  (COX) y lipoxigenasas (LOX). Los prostanoides, PGs y TXs, son efectores de una  amplia variedad de acciones en una enorme cantidad de células y tejidos. Se han  descripto acciones de los eicosanoides en diversos mecanismos fisiopatológicos  como contracción y relajación muscular, neurontransmisión, fiebre, inducción  del sueño, apoptosis, proliferación celular, oncogénesis. Asimismo se sabe que  estas moléculas son claves en la funcionalidad del sistema reproductor femenino  y en endometriosis, que es el tema que vamos a abordar en este capítulo.","palabras_clave":"ENDOMETRIOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89252,"idioma_id":4,"titulo":"Monitoring melatonin and its isomer in Vitis vinifera cv. Malbec by UHPLC-MS\/MS from grape to bottle","resumen":"Several studies have shown the presence of melatonin and relatedcompounds in grapes and wines. The latter provides evidence of thepossibility to enhance the nutraceutical properties of premium wines.However, there are many external factors that can influence the levels of thisindolamine in grape and wines. In this study, the monitoring of melatoninand its tentatively identified isomer was carried out during the entirewinemaking process in Vitis vinifera cv. Malbec by ultra high-performanceliquid chromatography-tandem mass spectrometry. Laboratory and pilotstudies were carried out to elucidate the role of grape, yeasts, and tryptophanin the evolution of the indolamines during the fermentation process.Melatonin was detected in grape extract within the range 120?160 ng\/g whileits isomer was found in musts and finished wines. Our results demonstratethat Saccaromyces cervisiae plays a decisive role in contributing to thecontent of melatonin and its isomer in wine.","palabras_clave":"GRAPES|MELATONIN|UHPLC-MS\/ MS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89253,"idioma_id":5,"titulo":"HETEROGENEIDADES TEXTURALES Y COMPOSICIONALES EN PRODUCTOS PIROCLÁSTICOS DE LA ERUPCIÓN DE 1960 DEL SISTEMA CORDÓN CAULLE (40°30?S, 72°10?O)","resumen":"Los depósitos de cenizas volcánicas son excelentes marcadores estratigráficos y cronológicos ya que pueden ser dispersados a cientos de kilómetros de su fuente. Sin embargo, su correlación puede ser problemática. Si bien la mayoría de los estudios basan estas correlaciones en análisis geoquímicos de roca total, las partículas volcánicas juveniles poseen gran heterogeneidad en cuanto a la forma de los fragmentos, textura y composición de la matriz y las fases minerales. Trabajos previos en niveles volcánicos identificados en una secuencia del lago Nahuel Huapi permitieron identificar los productos de la erupción del año 1960 del Sistema Cordón Caulle, presentando una gran variabilidad en el tipo de partículas volcánicas juveniles identificadas, como pómez blanca, marrón, escorias y trizas vítreas, con variaciones en la composición de roca total de cada tipo de partícula. Con esta información como base, en el presente trabajo se presentan los primeros análisis morfológicos, texturales y composicionales de los diferentes productos juveniles con el objeto de identificar el origen de las variaciones morfológicas y de geoquímica de roca total de las mismas. Los resultados permitieron asociar dichas diferencias a variaciones en el contenido de cristales y tamaño, forma y distribución de vesículas. Dicha variación, a su vez, fue relacionada a procesos de fraccionamiento previos a la erupción de 1960 del Sistema Cordón Caulle, generando información de valiosa utilidad para el uso de estos niveles como marcadores cronoestratigráficos.","palabras_clave":"CENIZAS VOLCÁNICAS|TEXTURA|GEOQUÍMICA|DATACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89254,"idioma_id":4,"titulo":"Spin-orbit induced chirality of Andreev states in Josephson junctions","resumen":"We study Josephson junctions (JJs) in which the region between the two superconductors is a multichannel system with Rashba spin-orbit coupling (SOC) where a barrier or a quantum point contact (QPC) is present.  These systems might present unconventional Josephson e\u000Bects such as Josephson currents for zero phase di\u000Berence or critical currents that  depend on the current direction. Here, we discuss how the spin polarizing properties of the system in the normal state a\u000Bect the spin characteristic of the Andreev bound states inside the junction. This results in a strong correlation between the spin of the Andreev states and the direction in which they transport Cooper pairs. While the current phase relation for the JJ at zero magnetic field is qualitatively unchanged by SOC, in the presence of a weak magnetic field a strongly anisotropic behavior and the mentioned anomalous Josephson e\u000Bects follow. We show that the situation is not restricted to barriers based on constrictions such as QPCs and should generically arise if in the normal system the direction of the carrier?s spin is linked to its direction of motion.","palabras_clave":"SPIN ORBIT|JOSEPHSON JUNCTIONS|ANDREEV STATES|QUANTUM TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89255,"idioma_id":4,"titulo":"BUTHIONINE SULFOXIMINE AND 1,25-DIHYDROXYVITAMIN D  INDUCE  APOPTOSIS  IN BREAST CANCER CELLS VIA INDUCTION OF REACTIVE OXYGEN SPECIES","resumen":"Calcitriol or 1,25(OH)2D3 is a negative growth regulator of breast cancer cells.  The aim of this study was to determine whether L-buthionine-S,R-sulfoximine, a  glutathione-depleting drug, modifies the antiproliferative effects of 1,25(OH)2D3 on  MCF-7 cells . For comparison, we included studies in MCF-7 cells selected for vitamin D  resistance and in human mammary epithelial cells transformed with SV40 and ras. Our  data indicate that L-buthionine-S,R-sulfoximine enhances the growth inhibition of  1,25(OH)2D3 in all transformed breast cell lines. This effect is mediated by ROS leading  to apoptosis. In conclusion, BSO alters redox state and sensitizes breast cancer cells to calcitriol mediated apoptosis","palabras_clave":"CALCITRIOL|BREAST CANCER|BSO|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89256,"idioma_id":4,"titulo":"Thermal Evolution and Stability of Pr2O3 - doped ZrO2 Powder and Thin Films","resumen":"ZrO2 powders and films with 5, 8, 9 and 10 mol % of Pr2O3 were prepared by a modified sol-gel method using liquid precursors. The thermal stability of the different phases is crucial in order to use this material in devices such as fuel cells, where the appearance of unwanted spurious phases causes a negative impact in the efficiency of such devices. DTA-TG and HT-XRD analysis carried out on the powders show that crystallization takes place around 500 °C. Heat treatments over 1000 °C produces destabilization of the initial crystallization cubic phase in the powders as well as in the films. However, aging treatments consisting in thermal cycles between room temperature and 750 °C, which is the temperature of technological interest, do not affect the structure, the microstructure and the stresses state of the Pr-doped ZO2 thin films.","palabras_clave":"zirconia|Praseodymiun|thermal evolution|thin films"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89257,"idioma_id":4,"titulo":"Effects of heavy metal concentrations (Cd, Zn and Pb) in agricultural soils near different emission sources on quality, accumulation and food safety in soybean [Glycine max (L.) Merrill]","resumen":"Argentina is one of the major producers of soybean in the world, this generates a high global demand for this crop leading to find it everywhere, even close to human activities involving pollutant emissions. This study evaluated heavy metal content, the transfer of metals and its relation to crop quality, and the toxicological risk of seed consumption, through soil and soybean sampling. The results show that concentrations of Pb and Cd in soils and soybeans at several sites were above the maximum permissible levels. The heavy metal bioaccumulation depending on the rhizosphere soil compartment showed significant and high regression coefficients. In addition, the similar behavior of Cd and Zn accumulation by plants reinforces the theory of other studies indicating that these metals are incorporated into the plant for a common system of transport. On the other hand, the seed quality parameters did not show a clear pattern of response to metal bioacumulation. Taken together, our results show that soybeans grown nearby to anthropic emission sources might represent a toxicological hazard for human consumption in a potential Chinese consumer. Hence, further studies should be carried out taking into account the potential negative health effects from the consumption of soybeans (direct or indirect through consumption of meat from cattle) in these conditions.","palabras_clave":"Glycine max|Heavy metals|Food safety|Emission|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89258,"idioma_id":4,"titulo":"Synthesis of imidazo[2,1-b]thiazoles linked to an unprotected carbohydrate moiety","resumen":"Two series of imidazo[2,1-b]thiazoles substituted on C-3 or C-5 with an unprotected carbohydrate moiety were synthesized. Different protective groups for position 3 of the carbohydrate moiety were ested (acetyl, tert-butyldimethylsilyl (TBDMS), and p-methoxybenzyl (PMB)) and the latter turn out to be the best strategy to obtain the desired products. Full deprotection of the carbohydrate was performed successfully in only one step.","palabras_clave":"HETEROCYCLES|CARBOHYDRATES|PROTECTIVE GROUPS|IMIDAZO[2,1-b]THIAZOLES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89259,"idioma_id":5,"titulo":"La construcción del territorio del noreste bonaerense: Patrones de paisaje, desarrollo económico y configuración político-territorial","resumen":"Desde principios del siglo XX, en el noreste bonaerense se constituyeron dos modelos de desarrollo bien diferenciados: uno basado en la productividad de la Pampa Deprimida, otro en el turismo urbano-costero. Las actividades económicas que aprovechan recursos paisajísticos con características y dinámicas muy diferentes, llevaron a una paulatina segregación entre municipios (denominados 'partidos') netamente costeros y netamente rurales. El objetivo de este trabajo fue analizar las relaciones entre las características del paisaje, los modelos productivos y la configuración político-territorial de la región bajo estudio. A partir de imágenes satelitales Landsat 5 TM, se elaboró un mapa de coberturas de la tierra y se analizó la estructura de los paisajes regionales a partir de índices paisajísticos. Se pusieron a prueba distintas zonificaciones ambientales, relacionadas con las características del paisaje y los modelos de desarrollo. Los resultados obtenidos indicaron que los disímiles modelos productivos de la zona costera y el interior rural se encuentran estrechamente vinculados a los patrones de paisaje, y que la configuración político-territorial ha ido evolucionando desde mitad del siglo XIX hasta la actualidad para ajustarse paulatinamente a esos patrones, en coincidencia con la zonificación ambiental.","palabras_clave":"Zona costera|Ecología de paisajes|Desarrollo territorial|Municipios costeros"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89260,"idioma_id":4,"titulo":"A modern subtropical playa complex: Salina de Ambargasta, central Argentina","resumen":"Salina de Ambargasta is a playa located at mid latitudes in central Argentina (29 Se64 W). Because of its hydrological behaviour, this playa complex can be subdivided into a closed system \u201Csensu-stricto\u201D and an \u201Copen-like system\u201D due to the presence of a seasonal outflow. Geomorphological and sedimentological features enable the separation of the Ambargasta playa into well-defined western, eastern and northern zones, where aeolian processes, groundwater supply and surface inflow, respectively, define distinctive sedimentary environments and typical processes of deposition. The following depositional settings were recognized: (1) alluvial fan; (2) sandflat; (3) springs; (4) dunes and paleo-dune field; (5)dry mudflat; (6) capillary mudflat; (7) ephemeral saline lake (includes saline mudflat and salt pan).The dry mudflat is present at the highest topographical zone, where the groundwater influence is less important and only intermittent ponds are present. In the capillary mudflat, evaporite sedimentation is limited to the development of efflorescence by evaporative pumping. The ephemeral saline lake, placed in the lowermost topographical region, alternates cycles of lake expansion and contraction responding to inter-annual hydrological variability as well as to seasonal variability. Lake expansion takes place during early austral summer (DecembereMarch), while continuous evaporation of brine leads to the growth of halite crystals during late summer. Sodium chloride-type brines result from both chemical fractionation as evaporation increases and salt dissolution. The isotopic compositions of surficial and underground waters (d18O and d2H) indicate that lake waters become isotopically enriched during summer when evaporation plays a significant role in the playa complex","palabras_clave":"Playa| Sedimentary subenvironment |Mud&#64258;at|Ephemeral lakes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89261,"idioma_id":4,"titulo":"Muds and salts from Laguna Mar Chiquita (or Mar de Ansenuza), Córdoba, Argentina: natural materials with potential therapeutic uses","resumen":"The Laguna Mar Chiquita, located in Cordoba´s province, Argentina, is the largest saline lake in South America, with a variable surface between 2,000 to 6,000 km2. During the last 50´and 60´ the mud collected directly from the bottom of the lake was extensively used for topical application over the skin and the salts precipitated in the coast were used for domiciliary baths. Subsequent water level increases (decades of the 70, 80, 90) diminish the possibility of using these materials. However, during the last decade the decline of water levels has increased the potential for reuse of muds and salt deposits of this lake. The aim of this study was to characterize the composition of the muds and salts obtained from Laguna Mar Chiquita like natural materials with potential therapeutic uses. The salinity of the water, 28 to 360 g\/L like minimum and maximum reported, has reached in the last decades values as low as 33 g\/L, with salt contents above 70 g\/L at the present. The predominant dissolved anion was chloride while sodium was the most important cation. Sulphate was present in minor proportions in the water but it was the most important anion in the precipitated salts. The pH was neutral or slightly alkaline. The dominant composition of the mud, with possible therapeutic application, was a mixture  of illite-like predominant phyllosilicate, quartz, plagioclase, feldspar, muscovite, calcite and halite. Waters and muds from Laguna Mar Chiquita showed significant similarity to those from the Lo Pagán in Mar Menor, Murcia, Spain, place in which widely promoted tourism is related to the use of muds with therapeutic purposes.","palabras_clave":"Laguna Mar Chiquita|sapropelic muds|evaporites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89262,"idioma_id":5,"titulo":"ARQUEOMALACOLOGÍA EN LAS COSTAS DE ANSENUZA: ANÁLISIS DE UNA ALMEJA NACARÍFERA (ANODONTITES TRAPESIALIS) HALLADA EN CONTEXTO FUNERARIO DEL SITIO EL DIQUECITO (LAGUNA MAR CHIQUITA, CÓRDOBA)","resumen":"Mollusk shells are relatively frequent items in archaeological sites from different regions of Argentina, as part of human diet, utilitarian or ornamental items, as well as rituals. In this paper we analyze the biological characteristics of a unique mollusk shell found in a burial context of a residential site located on the southern coast of Laguna Mar Chiquita or Mar de Ansenuza (Córdoba province) and its surrounding  environment, inferring the hydroclimatic conditions during the occupation of the site. Photographs were taken of the recovered material, and observations were made using binocular microscope. The specimen  was dated by AMS in 2077 ± 38 BP. The mollusk shell was classified as Anodontites trapesialis (Lam.),previously unreported in archaeological sites in the region, which lives in rivers and freshwater lakes, and  therefore would not have lived in Laguna Mar Chiquita. The specimen probably came from the tributary rivers or neighboring regions of North Pampas. The event would have taken place in a period characterized  by hydric oscillations, dry and probably very cold climate conditions.","palabras_clave":"Arqueomalacología|Bivalvo|paleoclima|Córdoba"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89263,"idioma_id":4,"titulo":"Efficient azoic dye degradation by Trametes trogii and a novel strategy to evaluate products released","resumen":"Culture filtrates from the white rot fungus Trametes trogii were used for the degradation of two azo dyes: Xylidine and Methyl Orange. These culture filtrates showed a great potential for decolorizing even high concentrations of both azo dyes, without the addition of redox mediators, possibly due to the synergistic action of their high contents of laccase (104 U ml-1), accompanied by Mn-peroxidase (0.54 U ml-1), cellobiose dehydrogenase (0.45 U ml-1) and glioxal oxidase (0.38 U ml-1) activities. 75% of Methyl Orange (980 ppm) and 96% of Xylidine (480 ppm) were degraded after 24 hs, degradation occurred after 6 days with a 94% of Xylidine removed (1440 ppm). Biodegradation products from Xylidine were determined by capillary electrophoresis followed by MALDI-TOF mass spectra. Neither aromatic amines nor colored quinones were detected, major metabolites being naphtalene sulphonate and xylene.","palabras_clave":"azo dyes |white rot fungi|capillary electrophoresis|MALDI-TOF mass spectra|degradation products"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89264,"idioma_id":4,"titulo":"Molecular response of Musca domestica L. to Mintostachys verticillata essential oil, (4R) (+)-pulegone and menthone.","resumen":"Intense applications of synthetic insecticides for the control of adult Musca domestica have led  to the insects developing resistance to most of them. In consequence, there is interest in new  active ingredients as alternatives to conventional insecticides. Essential oils (EO) are potential  tools for controlling M. domestica because of their effectiveness and their minimal environmental  effects. In a fumigant assay, M. domestica adults treated with Minthostachys verticillata EO  [LC50=0.5 mg\/dm3; majority components by SPME-GC: (4R)(+)-pulegone (67.5%), menthone  (22.3%) and (4R)(+)-limonene (3.8%)], died within 15 min or less. The terpenes absorbed by  the flies and their metabolites, analyzed using SPME fiber, were (4R)(+)-limonene  (LC50=6.2 mg\/dm3), menthone (LC50=1.9 mg\/dm3), (4R)(+)-pulegone (LC50=1.7 mg\/  dm3) and a new component, menthofuran (LC50=0.3 mg\/dm3), in a relative proportion of  12.4, 6.5, 35.9 and 44.2% respectively. Menthofuran was formed by oxidation of either  (4R)(+)-pulegone or menthone mediated by cytochrome P450, as demonstrated by a fumigation  assay on flies previously treated with piperonyl butoxide, a P450 inhibitor, which showed a  decrease in toxicity of the EO, (4R)(+)-pulegone and ofmenthone, supporting the participation  of the P450 oxidizing system in the formation of menthofuran. The enzymatic reaction of isolated  fly microsomes with the EO or the (4R)(+)-pulegone produced menthofuran in both cases.  Contrary to expectations, the insect detoxification system contributed to enhance the toxicity of  the M. verticillata EO. Consequently, resistant strains overexpressing P450 genes will be more  susceptible to either M. verticillata EO or (4R)(+)-pulegone and menthone.","palabras_clave":"Musca domestica|Minthostachys verticillata|(4R)(+)-Pulegone|Cytochrome P450"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89265,"idioma_id":4,"titulo":"Contribution of Subunits to Caenorhabditis elegans Levamisole-Sensitive Nicotinic Receptor Function","resumen":"Caenorhabditis elegans muscle contains seven different nicotinicreceptor (AChR) subunits, five of which have been shownto be components of adult levamisole-sensitive AChRs (LAChRs).To elucidate the reason for such subunit diversity, weexplore their functional roles in larva 1 (L1) muscle cells. Singlechanneland macroscopic current recordings reveal that the-type LEV-8 subunit is a component of native L1 L-AChRs butbehaves as a nonessential subunit. It plays a key role in maintaininga low rate and extent of desensitization of L-AChRs. Inthe absence of the -type ACR-8 subunit, L-AChR channelproperties are not modified, thus indicating that ACR-8 is not acomponent of L1 L-AChRs. Together with our previous findings,this study reveals that L1 muscle cells express a mainL-AChR type composed of five different subunits: UNC-38,UNC-63, UNC-29, LEV-1, and LEV-8. Analysis of a doublelev-8\/acr-8?null mutant, which shows an uncoordinated andlevamisole-resistant phenotype, reveals that ACR-8 can replaceLEV-8 in its absence, thus attributing a functional role tothis subunit. Docking into homology modeled L-AChRs proposesthat ACh forms the typical cation- interaction, suggestswhy levamisole is less efficacious than ACh, andshows that ACR-8 can form activatable binding-sites, thusopening doors for elucidating subunit arrangement and anthelminticselectivity.","palabras_clave":"C. ELEGANS|PATCH CLAMP|NICOTINIC RECEPTOR|ANTHELMINTIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89266,"idioma_id":4,"titulo":"Synthesis and structural and vibrational analysis of (5,7-dichloro-quinolin-8-yloxy) acetic acid","resumen":"We have prepared the (5,7-dichloro-quinolin-8-yloxy) acetic acid and characterized it by infrared andRaman spectroscopies in the solid phase and by nuclear magnetic resonance (NMR) spectroscopy in aCDCl3 solution. The density functional theory (DFT) together with the 6-31G and 6-311++G basis setswere used to study its structure and vibrational properties. Two stable conformations of the compoundwere theoretically determined in the gas phase and probably these conformations are present in the solidphase. The harmonic vibrational wavenumbers for the optimized geometries were calculated at the sametheory levels. For a complete assignment of all the observed bands in the vibrational spectra the DFT calculationswere combined with Pulay\u2019s scaled quantum mechanical force field (SQMFF) methodology inorder to fit the theoretical wavenumber values to the experimental ones. The force constants for the(5,7-dichloro-quinolin-8-yloxy) acetic acid were calculated and compared with those obtained for the(5-chloro-quinolin-8-yloxy) acetic acid and 2-(quinolin-8-yloxy)-acetic acid compounds. Furthermore,the characteristics of the electronic delocalization, the topological properties of the electronic charge densitytogether with the highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital(LUMO) energy gaps were studied","palabras_clave":"(5,7-Dichloro-quinolin-8-yloxy) acetic acid |Vibrational spectra| Molecular structure |Force field DFT calculations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89267,"idioma_id":4,"titulo":"The phylogenetic relationships of the Andean Swamp Rat genus Neotomys (Rodentia, Cricetidae, Sigmodontinae) based on mitochondrial and nuclear markers","resumen":"The aim of this study was to assess the phylogenetic position of the South American cricetid genus Neotomys using two molecular markers: one nuclear (Irbp) and one mitochondrial (mt-cyb). This genus is currently considered as incertae sedis in the Sigmodontinae radiation. The phylogenetic relationships were estimated using three approaches: Bayesian inference, maximum likelihood and parsimony. We found the genus Neotomys closely related to the genera Euneomys and Irenomys, which are also considered incertae sedis. Our results suggest a common origin for this group of genera; this fact should be reflected in the taxonomy as a supra generic group with a tribal level. However, further and deeper analysis of both, molecular and morphological data, are needed to diagnose and formalize the proposed tribe. The relationships of this clade to the other members of Sigmodontinae were not clear as assessed by this data set. The three genera are distributed around the Central and Southern Andes in South America evidencing that the Andes have played an important role in the diversification of several tribes of sigmodontine rodents.","palabras_clave":"Neotomys|Sigmodontinae|Phylogenetics|Cytochrome b"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89268,"idioma_id":4,"titulo":"Comparison of morpho-functional phytoplankton classifications in human impacted shallow lakes with different stable states","resumen":"The morpho-functional classifications ofphytoplankton have been recently proposed as usefultools in the aquatic biomonitoring. In this study, wecompared three different classifications in a range ofdifferent environmental conditions, a set of sixshallow lakes with different stable states. The studiedlakes are located in the Pampa Plain from Argentina, aregion highly impacted as a consequence of the humanactivities. Among the selected lakes, three are in aturbid state, two of which have high phytoplanktonabundances (phytoplankton-turbid), and one shows ahigh concentration of suspended inorganic matter(inorganic-turbid). Two lakes are clear and profuselycolonized by submerged plants (clear-vegetated).Only one lake shows a typical alternative steady-statebehavior, shifting turbid periods of high phytoplanktonbiomass with periods of more transparency anddevelopment of submerged macrophytes. We comparedthe three morpho-functional classificationsapplied by means of multivariate analyses in order toexplore how much the variance of the biomass of thephytoplankton functional groups (for each functionalclassification) was explained by the environmentalvariables. The analyses performed showed a clearseparation of the human-impacted turbid lakes fromthe clear-vegetated lakes. The advantages and disadvantagesof the different morpho-functional classificationsare discussed, concluding that the functionalapproach is adequate to analyze the phytoplanktoncommunities in aquatic systems subjected to anthropogenicinfluence and for monitoring them.","palabras_clave":"PHYTOPLANKTON|CLEAR AND TURBID SHALLOW LAKES|FUNCTIONAL GROUPS|PAMPA PLAIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89269,"idioma_id":5,"titulo":"Comportamiento en desgaste deslizante de polietileno de alta densidad entrecruzado con radiación gamma","resumen":"El propósito del trabajo fue evaluar el comportamiento de polietilenos irradiados con rayos gamma sometidos a desgaste deslizante. Para ellos se utilizaron dos polietilenos lineales, que fueron irradiados con radiación gamma a temperatura ambiente, aplicándose a cada grupo dosis de 2, 5, 10 y 20 Mrad. Los estudios tribológicos fueron realizados usando un tribómetro Pin On Disc. Los ensayos se efectuaron aplicando cargas normales entre 2,5 y 15 N. Se encontró que la velocidad de desgaste se incrementa con la carga aplicada en los materiales irradiados con bajas dosis, mientras que aquellos irradiados con las dosis más altas la velocidad de desgaste atraviesa por un valor máximo con la carga.       ","palabras_clave":"Desgaste deslizante|Entrecruzamiento por irradiación|Polietileno"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89270,"idioma_id":5,"titulo":"Comportamiento térmico en mezclas de caucho natural y caucho estireno butadieno. Un estudio mediante DSC","resumen":"Se presenta un estudio del comportamiento térmico de mezclas elastoméricas vulcanizadas de caucho natural(NR) y de caucho estireno-butadieno (SBR). Como técnica experimental se usó la calorimetría diferencial de barrido (DSC). Se estudiaron 10 mezclas con diferentes composiciones NR\/SBR, usando el sistema de cura azufre\/acelerante TBBS, las cuales fueron vulcanizadas a 160ºC durante un tiempo de cura óptimo el cual se determinó por ensayos reométricos. Además se midió una mezcla física de partes iguales de NR y SBR, previamente ambos elastómeros fueron vulcanizados usando el mismo procedimiento de cura. Las muestras se sometieron a un procedimiento de calentamiento\/enfriamiento\/calentamiento entre -90ºC y 0ºC a una tasa de  10ºC\/min. De los termogramas obtenidos se estimaron las temperaturas de transición vítrea, Tg, de cada fase en el compuesto y se analizó la variación de este parámetro con la composición. Con el objetivo de comparar los resultados con los de las mezclas curadas, usando la misma configuración experimental, se estudiaron muestras puras de NR y SBR no vulcanizadas y se analizó la influencia de la estructura del reticulado sobre la Tg. Sobre la base de los resultados obtenidos, se discute la influencia de la interfase generada en la mezcla entre el SBR y el NR.","palabras_clave":"CAUCHO NATURAL|STIRENO BUTADIENO|MEZCLAS ELASTOMÉRICAS|CALORIMETRÍA DIFERENCIAL DE BARRIDO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89271,"idioma_id":4,"titulo":"Magnetic behavior of Mg - Al - Zn - Fe mixed oxides from precursors layered double hydroxide","resumen":"Mixed oxides of Mg-Al-Zn-Fe were obtained by calcination of layered double hydroxides (LDH) prepared by coprecipitation reaction with hydrothermal treatment. The structural characterization of precursors and oxides was carried out by X rays diffraction, showing increases of ZnO phase with the increase of the zinc content. Magnetic behavior was studied by vibrating sample magnetometer (VSM) and by a superconducting quantum interference device (SQUID) showing both paramagnetic and super paramagnetic behavior depending on both particles size and composition.","palabras_clave":"Mixed oxides|Magnetic properties"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89272,"idioma_id":4,"titulo":"Form and function within a phylogenetic framework: locomotory habits of extant predators and some Miocene Sparassodonta (Metatheria)","resumen":"In this study, we analysed locomotory habits in extant predators and Sparassodonta species through geometric morphometric techniques and discriminant analyses of the distal humerus in anterior view, proximal ulna inlateral view, and tibia in proximal view. We included a wide sample of extant predators, and considered the phylogenetic and allometric structure in the data sets. We also included some Sparassodonta, a group of carnivorous metatherians that inhabited South America during the Cenozoic, and inferred their locomotory habits.Results suggest the presence of a close relationship between shape and locomotory habits, even after removing the shape component explained by phylogeny in the three postcranial elements. Terrestrial habits were inferred forArctodictis sinclairi, Borhyaena tuberata, \u2018Lycopsis\u2019 longirostrus, and Thylacosmilus atrox. Some degree of cursoriality was highlighted in B. tuberata and T. atrox, and climbing abilities in \u2018L.\u2019&nbsp; longirostrus, and to a lesser degree in B. tuberata. Scansorial habits were inferred for Cladosictis patagonica, Sipalocyon gracilis, Prothylacynus patagonicus, and Pseudonotictis pusillus, and in the case of C. patagonica, some digging ability was also tentatively inferred.","palabras_clave":"ALLOMETRY|COMPARATIVE METHODS|GEOMETRIC MORPHOMETRICS|LOCOMOTION|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89273,"idioma_id":4,"titulo":"DNA methylation index and methylation profile of invasive ductal breast tumors","resumen":"The goal of this study was to identify alterations in DNA methylation related to invasive ductal carcinomas, evaluating the methylation status of 49 CpG islands (CpG) localized within 34 cancer-involved genes. Our key findings reveal epigenetic alterations which could contribute to a better understanding of the heterogeneity of breast tumorigenesis; and their relationship with previously known prognostic factors. We found that the epigenetic signature is specific for each invasive ductal carcinoma. WT1 and RASSF1 are frequently methylated in IDC. Invasive ductal carcinomas are organized in hierarchical clusters based on the epigenetic information. The methylation status of p73 and RARB is associated with clinic and pathological factors. The concurrent methylation of p73 and RARB is associated with poor prognostic factors. Tumors with poor prognostic factors present a high methylation index. Our study results indicate that MI and methylation of p73 and\/or RARB are related to unfavorable prognostic factors of patients with IDCs. Therefore, these epigenetics markers could be included in further studies to improve the molecular diagnosis of patients with invasive ductal carcinomas.&nbsp;                                                                                                                                   ","palabras_clave":"METHYLATION INDEX|RETINOIC ACID RECEPTOR BETA|TUMOR PROTEIN P73|BREAST CANCER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89274,"idioma_id":4,"titulo":"Methylation profile of triple negative breast carcinomas","resumen":"Breast cancer is a group of clinically, histopathologically and molecularly heterogeneous diseases, with different outcomes and  responses to treatment. Triple-negative (TN) breast cancers are defined as tumors that lack the expression of estrogen receptor,  progesterone receptor and epidermal growth factor receptor 2. This subgroup accounts for 15% of all types of breast cancer and its  prevalence is higher among young African, African-American and Latino women. The hypermethylation of CpG islands (CpGI) is a  common epigenetic alteration for suppressing gene expression in breast cancer and has been shown to be a key factor in breast  carcinogenesis. In this study we analyzed the hypermethylation of 110 CpGI within 69 cancer-related genes in TN tumors. For the  methylation analysis, we used the methyl-specific multiplex-ligation probe amplification assay. We found that the number of  methylated CpGI is similar between TN and non-TN tumors, but the methylated genes between the groups are different. The  methylation profile of TN tumors is defined by the methylation of five genes (that is, CDKN2B, CD44, MGMT, RB and p73) plus the  non-methylation of 11 genes (that is, GSTP1, PMS2, MSH2, MLH1, MSH3, MSH6, DLC1, CACNA1A, CACNA1G, TWIST1 and ID4). We  conclude that TN tumors have a specific methylation profile. Our findings give new information for better understanding tumor  etiology and encourage future studies on potential drug targets for triple-negative breast tumors, which now lack a specific  treatment.","palabras_clave":"CpG ISLAND|TRIPLE NEGATIVE BREAST TUMORS|METHYLATION PROFILE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89275,"idioma_id":4,"titulo":"Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin","resumen":"Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive  physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and  significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we  investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity  and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino  swiss mice were injected (sc) daily with HEXr: 100 mgkg1 day1 (HEXr D1) or 200 mgkg1 day1 (HEXr D2) for 53  days in males and 30 days in females.We detected a significantly decreased ratio in the number of fetuses per corpora lutea  in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a  downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the  analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose  certain effects of HEXr on the implantation process and\/or early development of embryos and over the in vivo reproductive  capability of males.","palabras_clave":"GHRELIN|GROWTH HORMONE SECRETAGOGUES|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89276,"idioma_id":4,"titulo":"Reproduction in chinchilla (Chinchilla lanigera): current status of environmental control of gonadal activity and advances in reproductive techniques.","resumen":"A review of the biology of reproduction of chinchilla, focusing on environmental control of the gonadal activity, is presented.Chinchilla is a South American hystricomorph rodent genus currently considered almost extinct in the wild. However, a domesticform is still widespread in breeding farms around the world. Information regarding their reproductive biology has been obtainedfrom studies on captive animals. In the case of Chinchilla lanigera, a seasonal reproductive pattern has been frequently reportedin breeding facilities, but factors that might trigger gonadal activity have not been identified. The available information onreproductive productivity in farms worldwide shows a range of 1.2 to 2.4 deliveries per female per yr (with up to 2.1 weanedyoung per female per yr). Indeed, as found in all rodents, chinchillas can multiply at high fecundity and fertility rates (4 to 6follicles mature during estrous cycles). Some new research avenues are postulated to improve the control of gonadal activity bymeans of environmental and\/or pharmacologic factors. Furthermore, reproductive techniques that have been validated in chinchillaare reviewed (noninvasive hormone monitoring, semen collection, sperm cryopreservation, estrus induction), and several technicalsteps are proposed to be able to achieve AI. Because domesticated chinchilla still share some genomic characteristics with theircounterparts in the wild, validated reproductive techniques in chinchilla males and females might contribute to the success ofbreeding programs.Chinchilla lanigera, a seasonal reproductive pattern has been frequently reportedin breeding facilities, but factors that might trigger gonadal activity have not been identified. The available information onreproductive productivity in farms worldwide shows a range of 1.2 to 2.4 deliveries per female per yr (with up to 2.1 weanedyoung per female per yr). Indeed, as found in all rodents, chinchillas can multiply at high fecundity and fertility rates (4 to 6follicles mature during estrous cycles). Some new research avenues are postulated to improve the control of gonadal activity bymeans of environmental and\/or pharmacologic factors. Furthermore, reproductive techniques that have been validated in chinchillaare reviewed (noninvasive hormone monitoring, semen collection, sperm cryopreservation, estrus induction), and several technicalsteps are proposed to be able to achieve AI. Because domesticated chinchilla still share some genomic characteristics with theircounterparts in the wild, validated reproductive techniques in chinchilla males and females might contribute to the success ofbreeding programs.","palabras_clave":"CHINCHILLA|REPRODUCTION|PHOTOPERIOD|SEMEN COLLECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89277,"idioma_id":5,"titulo":"Impacto de la obesidad en la función reproductiva masculina.","resumen":"RESUMEN\t\t\t\t\tTanto la obesidad como la infertilidad masculina han \t\t\t\t\taumentado durante las últimas décadas por lo que se ha \t\t\t\t\texplorado una posible asociación entre estas patologías. Los \t\t\t\t\testudios informan que la obesidad puede afectar la \t\t\t\t\tfertilidad del varón por diferentes mecanismos, los que en \t\t\t\t\túltima instancia, pueden provocar disfunción eréctil y\/o \t\t\t\t\tdeteriorar la calidad espermática. Dichos mecanismos \t\t\t\t\tincluyen: 1) disrupción en la fisiología del eje hipotálamo-hipófiso-testicular \t\t\t\t\t(HHT): disminución en la concentración sérica de \t\t\t\t\ttestosterona, gonadotrofinas, SHBG y\/o inhibina B e \t\t\t\t\thyperestrogenemia; 2) incremento en la liberación de \t\t\t\t\thormonas derivadas del tejido adiposo, entre ellas leptina, \t\t\t\t\tque podrían alterar la fisiología del eje HHT y\/o afectar \t\t\t\t\tdirectamente las células de Leydig y la espermatogénesis; 3) \t\t\t\t\taumento de las adipoquinas (proinflamatorias), incremento de \t\t\t\t\tla temperatura escrotal y acumulación de disruptores \t\t\t\t\tendócrinos en los adipocitos; todos ellos responsables de un \t\t\t\t\taumento en el estrés oxidativo testicular y 4) la apnea del \t\t\t\t\tsueño, frecuente en obesos, que suprime el pico nocturno de \t\t\t\t\ttestosterona necesario para la espermatogénesis. Finalmente, \t\t\t\t\tsi bien está discutido, estos mecanismos podrían alterar la \t\t\t\t\tespermatogénesis y\/o la maduración epididimaria, \t\t\t\t\tdisminuyendo así la concentración y la motilidad espermática \t\t\t\t\ty aumentando la fragmentación del ADN.\t\t\t\t\tEn resumen, si bien la obesidad puede afectar la fertilidad \t\t\t\t\tmasculina por algunos\/todos los mecanismos mencionados, lo \t\t\t\t\tcierto es que sólo una pequeña proporción de obesos son \t\t\t\t\tinfértiles; probablemente aquéllos con obesidad mórbida o \t\t\t\t\tgenéticamente predispuestos. Sin embargo, ya que la \t\t\t\t\tincidencia de obesidad sigue aumentando, es de esperar que \t\t\t\t\tel número de hombres con sub\/infertilidad también lo haga.\t\t\t\t\t","palabras_clave":"obesidad|semen|reproducción"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89278,"idioma_id":4,"titulo":"New records and notes on gasteroid fungi of arid lands in Argentina","resumen":"A survey of gasteroid fungi from arid regions in the La Rioja province (northwestern Argentina) resulted in 20 species of 13 genera. Each species is briefly commented on and descriptions are provided for taxa poorly known or with few records in the world. In addition,photographs of basidiomata and SEM micrographs illustrating basidiospores are provided  for most of the taxa. The most noticeable records are Bovista grandipora, new for Argentina,Schizostoma argentinense with few records in the world, and Vascellum intermedium and Disciseda verrucosa, new for South America. In addition, the distribution of the species among the main types of habitat is discussed in relation to spore release and humidity.  Keywords: desert, ecology, Gasteromycetes, spore dispersion.","palabras_clave":"Geastrum|Tulostoma|Disciseda|Spores"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89279,"idioma_id":4,"titulo":"Geastrum species of the La Rioja province, Argentina","resumen":"A survey of Geastrum species from arid lands in the La Rioja province (northwestern Argentina) recovered fourteen species previously unreported from the province: G. arenarium, G. campestre var. famatinum, G. corollinum, G. fimbriatum, G. floriforme, G. glaucescens, G. hieronymi, G. aff. lloydianum, G. pampeanum, G. pampeanum var. pallidum, G. parvistriatum, G. rufescens, G. saccatum, and G. schmidelii. Of these, new records are G. corollinum for Argentina, G. arenarium for South America, and G. parvistriatum for the Americas, and G. campestre var. famatinum is proposed as a new variety. Each taxon is described, and photographs of basidiomes and SEM micrographs illustrating spores are provided for selected taxa.","palabras_clave":"GEASTRALES|MYCOBIOTA|PHALLOMYCETIDAE|TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89280,"idioma_id":4,"titulo":"Complex gas kinematics in compact, rapidly assembling star-forming galaxies","resumen":"Deep, high-resolution spectroscopic observations have been obtained for six compact, strongly star-forming galaxies at redshift z ~ 0.1-0.3, most of them also known as green peas. Remarkably, these galaxies show complex emission line profiles in the spectral region including Halpha, [N II] 6548, 6584A, and [S II] 6717, 6731A, consisting of the superposition of different kinematical components on a spatial extent of few kiloparsecs: a very broad line emission underlying more than one narrower component. For at least two of the observed galaxies some of these multiple components are resolved spatially in their two-dimensional spectra, whereas for another one a faint detached Halpha blob lacking stellar continuum is detected at the same recessional velocity ~7 kpc away from the galaxy. The individual narrower Halpha components show high intrinsic velocity dispersion (sigma ~ 30-80 km\/s), suggesting together with unsharped masking Hubble Space Telescope images that star formation proceeds in an ensemble of several compact and turbulent clumps, with relative velocities of up to ~500 km\/s. The broad underlying Halpha components indicate in all cases large expansion velocities (full width zero intensity 1000 km\/s) and very high luminosities (up to ~10^42 erg\/s), probably showing the imprint of energetic outflows from supernovae. These intriguing results underline the importance of green peas for studying the assembly of low-mass galaxies near and far. ","palabras_clave":"galaxies: dwarf|galaxies: evolution|galaxies: kinematics and dynamics|galaxies: starburst"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89281,"idioma_id":4,"titulo":"Species delimitation in Lippia section Goniostachyum (Verbenaceae) using the Phylogenetic Species Concept","resumen":"Lippia section Goniostachyum comprises plants distinguished by their numerous axillary florescences (three to six, sometimes up to nine) and tetrastichous floral bracts. Species of section Goniostachyum occur in the Neotropics, from Mexico to northern Argentina. Delimitation of the species grouped under Goniostachyum has remained unclear. Forty-one names exist under this section, but only c. eight to ten names have been used frequently. To resolve the taxonomy of this group, a modified population aggregation analysis, based on the phylogenetic species concept, was employed. As a result, Goniostachyum is here circumscribed to only four species: L. grata, L. origanoides, L. sericea and L. stachyoides. These species are supported by different combinations of three characters of the 13 qualitative attributes analysed: canescent sericeous pubescence, frondose or frondose-bracteose inflorescences and free or fused florescence apical bracts. Two varieties based on significant differences among quantitative characters are recognized: L. stachyoides var. stachyoides and L. stachyoides var. martiana comb. nov. Fifteen lectotypifications and four neotypifications are proposed.","palabras_clave":"AGGREGATION ANALYSIS |NEOTROPICS |POPULATION |TAXONOMY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89282,"idioma_id":5,"titulo":"ANÁLISIS DE LA RADIACIÓN SOLAR EN EL NORTE DE CHILE. COMPARACIÓN ENTRE  DATOS MEDIDOS Y ESTIMADOS POR MODELOS DE DÍA CLARO ARG-P Y BASE DE DATOS  SWERA.","resumen":"Los&nbsp; valores&nbsp; de&nbsp; radiación&nbsp; solar&nbsp; media&nbsp; diaria&nbsp; anual&nbsp; disponibles&nbsp; en&nbsp; la&nbsp; región&nbsp; que&nbsp; abarca&nbsp; el&nbsp; norte&nbsp; de&nbsp; Chile,&nbsp; el sudoeste de Bolivia y el noroeste de Argentina, serian superiores a 8.5 KWh\/m2 día, siendo de los pocos sitios del planeta con estos&nbsp; altos&nbsp; valores&nbsp; de&nbsp; energía&nbsp; solar.&nbsp; Sin&nbsp; embargo,&nbsp; ese&nbsp; valor&nbsp; es&nbsp; una&nbsp; estimación&nbsp; calculada&nbsp; a&nbsp; partir&nbsp; de&nbsp; modelos&nbsp; que&nbsp; utilizan imágenes satelitales y pocos datos medidos en superficie. Para determinar el grado de veracidad de esta estimación, en este trabajo se compararon los valores medios mensuales&nbsp; de radiación solar global medidos en 8 estaciones ubicadas en Chile, contra&nbsp; valores&nbsp; de&nbsp; la&nbsp; base&nbsp; de&nbsp; datos&nbsp; satelital&nbsp; SWERA&nbsp; y&nbsp; estimados&nbsp; con&nbsp; el&nbsp; modelo&nbsp; de&nbsp; día&nbsp; claro&nbsp; ARG-P.&nbsp; Se&nbsp; calcularon&nbsp; las irradiancias de día promedio (IDP) de cada mes paracada estación; se calculó la irradiación de esos días promedios y se realizó&nbsp; un&nbsp; análisis&nbsp; de&nbsp; las&nbsp; diferencias&nbsp; entre&nbsp; los&nbsp; valores&nbsp; medidos&nbsp; y&nbsp; los&nbsp; estimados&nbsp; por&nbsp; SWERA&nbsp; y&nbsp; ARG-P,&nbsp; a&nbsp; los&nbsp; efectos&nbsp; de determinar la validez del uso de las base de datos SWERA como fuente confiable con error conocido.","palabras_clave":"irradiacion solar global|SWERA|Chile|ARG-P"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89283,"idioma_id":4,"titulo":"Eye movements blink the Attentional Blink","resumen":"When presented with a sequence of visual stimuli in rapid succession, participants often fail to detect a  second salient target, a phenomenon referred as the attentional blink (AB; Raymond, Shapiro, & Arnell,  1992; Shapiro, Raymond, & Arnell, 1997). On the basis of a vast corpus of experiments, several cognitive  theories suggest that the blink results from a discrete structuring of attention, sampling information from  temporal episodes during which several items can access encoding process (Wyble, Bowman, &  Nieuwenstein, 2009; Wyble, Potter, Bowman, & Nieuwenstein, 2011). The objective of this work is to  explore the AB when multiple items are presented at the fovea during ocular movements. The authors  reasoned that each fixation may cohesively form an episode and hence expected that the blink may vanish  within a single fixation. In turn, they expected saccades to accentuate episodic borders and hence shorten  the regime of interference when 2 targets are presented fovealy in successive fixations. Evidence is  provided in favor of this hypothesis, showing that the blink vanishes when both targets are presented in  the core of a single fixation (far from the saccadic boundaries) and that it recovers more rapidly in  successive fixations. These studies support current views that episodes should have an effect on the AB  and provide evidence that eye movements play an important role in the formation of episodes.","palabras_clave":"attentional blink|eye movements, |episodes,|attention"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89284,"idioma_id":4,"titulo":"Fixation-related potentials in visual search: A combined EEG and eye tracking study","resumen":"We report a study of concurrent eye movements and electroencephalographic (EEG) recordings while subjects freely explored  a search array looking for hidden targets. We describe a sequence of fixation-event related potentials (fERPs) that unfolds  during ; 400 ms following each fixation. This sequence highly resembles the event-related responses in a replay experiment,  in which subjects kept fixation while a sequence of images occurred around the fovea simulating the spatial and temporal  patterns during the free viewing experiment. Similar responses were also observed in a second control experiment where the  appearance of stimuli was controlled by the experimenters and presented at the center of the screen. We also observed a  relatively early component (;150 ms) that distinguished between targets and distractors only in the freeviewing condition. We  present a novel approach to match the critical properties of two conditions (targets\/distractors), which can be readily adapted  to other paradigms to investigate EEG components during free eye-movements.","palabras_clave":"ERP  |Eye Movements|Visual Search|Target Detection"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89285,"idioma_id":4,"titulo":"CUDAICA: GPU optimization of Infomax- ICA EEG analysis","resumen":"In recent years Independent Component Analysis (ICA) has become a standard to identify relevant dimensions of the data in neuroscience. ICA is a very reliable method to analyze data but it is, computationally, very costly. The use of ICA for on-line analysis of the data, used in brain computing interfaces, results almost completely prohibitive. We show an increase with almost no cost (a rapid video card) of speed of ICA by about 25 fold. The EEG data, which is a repetition of many independent signals in multiple channels is very suitable for processing using the vector processors included in the graphical units. We profiled the implementation of this algorithm and detected two main types of operations responsible of the processing bottleneck and taking almost 80% of computing time: vector-matrix and matrix-matrix multiplications. By replacing function calls to basic linear algebra functions to the standard CUBLAS routines provided by GPU manufacturers, does not increase performance due to CUDA kernel launch overhead. Instead, we developed a GPU-based solution that, comparing with the original BLAS and CUBLAS versions, obtains a 25x increase of performance for the ICA calculation.","palabras_clave":"Independent Component Analysis|electroencephalography|GPU"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89286,"idioma_id":5,"titulo":"ANÁLISIS INTEGRADO DEL PERIURBANO DE LA CIUDAD DE MAR DEL PLATA, A PARTIR DE LA IDENTIFICACIÓN Y CARACTERIZACIÓN DE UNIDADES AMBIENTALES. [Indexaciones: Latindex]","resumen":"RESUMEN Las áreas periurbanas constituyen zonas de interfase sujetas a transformaciones constantes que suelen manifestar desajustes en la articulación sociedad-naturaleza. Dichos desajustes se traducen en problemas asociados con degradaciones ecológicas, superposiciones e incompatibilidades de usos de suelo, dificultades para dotar de equipamientos y servicios públicos a la población, exposición a situaciones de riesgo, procesos de contaminación, entre otros. El periurbano de Mar del Plata (Partido de General Pueyrredon, 614.350 habitantes), evidencia muchos de los problemas mencionados. Así, la ordenación territorial se concibe como un instrumento de gestión que intenta definir aptitudes espaciales para la localización de actividades y dar respuesta a los conflictos emergentes en estos espacios. Partiendo de estudios previos, el presente trabajo propone realizar un análisis integrado del periurbano marplatense, a partir de la identificación y caracterización de unidades ambientales. Se pretende con ello, elaborar una base diagnóstica que contribuya con la ordenación territorial del periurbano. La definición de unidades ambientales implica integrar diferentes atributos correspondientes a los subsistemas natural, social y de infraestructura, y económico-productivo. Ello demandó, la identificación de subunidades homogéneas en cada uno de los subsistemas mencionados. Con ese fin, se utilizó un Sistema de Información Geográfica, se recurrió a distintas fuentes de información, se realizaron estudios en campo y se aplicaron técnicas y métodos específicos requeridos para el abordaje de cada subsistema. Se identificaron 29 unidades homogéneas correspondientes al subsistema natural, 3 situaciones diferentes de condiciones de vida, 3 de infraestructura y 10 usos de suelo dominantes. El análisis integrado, permitió caracterizar alrededor de 100 unidades ambientales, las cuales expresan diferentes formas de articulación sociedad-naturaleza en el periurbano. El procedimiento empleado permitió definir zonas con características distintas dentro del periurbano, que demandan la formulación de lineamientos y alternativas de gestión territorial particulares. Estas posibles líneas de intervención, se identifican y describen en el estudio.","palabras_clave":"INTERFACE URBANO-RURAL|USOS DEL SUELO|RÉGIMEN DE RUPTURA|ORDENAMIENTO TERRIROTIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89287,"idioma_id":4,"titulo":"When order matters: last-come first-served effect in sequential arithmetic operations","resumen":"Cognitive psychologists have relied on dual-task interference experiments to understand the low-capacity and serial nature of conscious mental operations. Two widely studied paradigms, the Attentional Blink (AB) and the Psychological Refractory Period (PRP) have demonstrated a 'first-come first-served' policy; processing a stimulus either impedes conscious access (AB) or postpones treatment (PRP) of a concurrent stimulus. Here we explored the transition from dual-task paradigms to multi-step human cognition. We studied the relative weight ofindividual addends in a sequential arithmetic task, where number notation (symbolic\/non-symbolic) and presentation speed were independently manipulated. For slow presentation and symbolic notation, the decision relied almost equally on all addends, whereas for fast ornon-symbolic notation, the decision relied almost exclusively on the last item reflecting a last-come first-served policy. We suggest that streams of stimuli may be chunked in events in which the last stimuli may override previous items from sensory buffers.","palabras_clave":"Sequential operations|arithmetic|decision-making|multi-step cognition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89288,"idioma_id":5,"titulo":"La prevalencia de geohelmintiasis se relaciona con las condiciones socio-ambientales","resumen":"Se realizó un estudio socioambiental y parasitológico en niños de áreas urbanas, periurbanas y rurales de las provincias de Buenos Aires y Misiones. Se completó una encuesta epidemiológica y se tomaron muestras fecales seriadas, las cuales se analizaron mediante técnicas de flotación y sedimentación. Del total de muestras fecales (1 893), 5.5% fueron positivas en Buenos Aires y 25.6% en Misiones. El área periurbana de Misiones presentó la mayor prevalencia de parasitosis total (34.1%) y de biparasitados y poliparasitados (45.4%). Las especies más prevalentes fueron Strongyloides stercoralis (22.1%) en el sector periurbano y Ancylostomideos (21.6%) en el área rural de Misiones. Hymenolepis nana y Ascaris lumbricoides mantuvieron bajas frecuencias en ambas provincias y Trichuris trichiura sólo se encontró en el periurbano de Buenos Aires. La prevalencia de geohelmintos aumentó con la edad (p < 0.05) y se asoció en el área periurbana de ambas provincias y rural de Misiones con las condiciones socioambientales: vivienda precaria, piso de tierra, eliminación de excretas en letrinas o a cielo abierto, sin recoleccióndomiciliaria de residuos, madre sin actividad laboral, padres sin instrucción primaria (p < 0.05). Las características biogeográficas y las condiciones socioambientales de la provincia de Misiones favorecen lapersistencia de las formas parasitarias en el ambiente.","palabras_clave":"geohelmintos|condiciones socioambientales|Buenos Aires|Misiones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89289,"idioma_id":4,"titulo":"Differential expression of PDZ-containing proteins in human diseases: challenging topics and novel issues","resumen":"The general features of PDZ domains structure and functions have been extensively studied during the last decade. The PDZ domains are generally present in proteins involved in multiple interactions that allow the assembly of functional protein complexes that control key cellular processes. One of the best characterized functions of the PDZ-containing proteins is the control of epithelial cell polarity and cell-cell contacts. In the present review we summarize the current knowledge about the regulation of the expression of certain PDZ polarity proteins that localized at the intercellular junctions. In addition, we provide a critical overview of recent findings about the role of these proteins during the development of human diseases. The complete understanding of these issues would be valuable for the design of novel therapeutic intervention for common pathologies, such as cancer.","palabras_clave":"PDZ PROTEINS|REGULATION|EXPRESSION|CANCER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89290,"idioma_id":4,"titulo":"Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system","resumen":"The aim of this study was to evaluate the role of NAD(P)H oxidase in liver oxidative stress  (OS), the metabolic changes induced by a fructose-rich diet (FRD), and their prevention by  apocynin co-administration. Wistar rats were fed for 21 days a) a control diet, b) a control diet  plus 10% fructose in the drinking water, and c) a control and FRD diet plus apocynin in the  drinking water. Glycemia, triglyceridemia and insulinemia were measured and the  homeostasis model of assessment of insulin resistance (HOMA-IR) ratio calculated. In liver  we measured a) NAD(P)H oxidase activity, gene and protein expression, b) protein carbonyl  groups, reduced glutathione (GSH) and lipid peroxidation, c) catalase, CuZn-superoxide  dismutase (CuZnSOD) and Mn-superoxide dismutase (MnSOD) gene and protein expression,  d) liver glycogen and triglyceride content, and e) glucokinase (GK), glucose-6-phosphatase  (G-6-Pase) and glucose-6-phosphate dehydrogenase (G-6-P DH) activities. FRD animals  showed hypertriglyceridemia, hyperinsulinemia and higher activity\/expression of NAD(P)H  oxidase, increased OS markers, reduced antioxidant enzyme expression, enhanced liver  glycogen and triglyceride storage, and increased GK, G-6-Pase and G-6-P DH activities. In  FRD rats, apocynin co-administration reduced triglyceridemia but not hyperinsulinemia, and  normalized NAD(P)H oxidase expression and activity together with OS markers and  antioxidant enzymes. Apocynin also prevented hepatic triglyceride accumulation. In  conclusion, NAD(P)H oxidase plays a key role in FRD-induced hepatic reactive oxygen  species production and could also be involved in liver steatosis. Apocynin prevents most of  these alterations, thus suggesting its potential usefulness for the prevention\/treatment of the  metabolic syndrome and type 2 diabetes mellitus.","palabras_clave":"apocinina|fructosa|trastorno metabólico hepático|insulinorresistencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89291,"idioma_id":4,"titulo":"Production of structured lipids by acidolysis with immobilized Rhizomucor miehei lipases: selection of suitable reaction conditions","resumen":"Enzymatic modification of vegetable oils can be used to produce plastic fat or structured lipids (SL) avoiding the generation of trans fatty acids. Biocatalysts previously prepared by immobilization of Rhizomucor miehei lipases onto alkylated chitosan microspheres were used to synthesize SL by acidolysis reaction of sunflower oil and palmitic?stearic acids mixture. Effects of some reaction parameters, substrate molar ratio (SR), amount of biocatalyst (E) and amount of solvent (H), over selected response variables were analyzed by applying an incomplete factorial design of three factors with three levels   (Box?Behnken). Responses were selected to evaluate not only the   development of desired TAG but also the yield and quality of obtained   products, through by-products and undesired trisaturated lipids   quantification. The analysis of variable effects showed that E was the most significant factor on each analyzed response. Multiresponse optimization with restrictions from practical considerations revealed that maximum saturated fatty acids composition in glycerides of the SL (38.6%) is obtained when SR = 3, E = 0.34 g and H = 3.2 ml are used. Under these conditions, a change in the composition of the desired TAG group (monounsaturated TAG) from 2.5% in the original oil to 33.9% in the final product was achieved. On the other hand, time and temperature behavior studies showed that generation of trisaturated triacylglycerols and by-products were favored mainly by increasing temperature. After 12 h of reaction, overall hydrolysis and esterification reactions rates were comparable. However, TAG   distribution continued changing.","palabras_clave":"ACIDOLYSIS |STRUCTURED LIPIDS |SUNFLOWER OIL|SATURATED FATTY ACIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89292,"idioma_id":4,"titulo":"CDK2 and PKA Mediated-sequential Phosphorylation is Critical for p19INK4d  function in the DNA damage response","resumen":"DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4\/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into the activation mechanism of p19INK4d linked to the response to DNA damage. Results showed that p19INK4d becomes phosphorylated following UV radiation, &#946;-amyloid peptide and cisplatin treatments. ATM-Chk2\/ATR-Chk1 signaling pathways were found to be differentially involved in p19INK4d phosphorylation depending on the type of DNA damage. Two sequential phosphorylation events at serine 76 and threonine 141 were identified using p19INK4d single-point mutants in metabolic labeling assays with 32P-orthophosphate. CDK2 and PKA were found to participate in p19INK4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively. Nuclear translocation of p19INK4d induced by DNA damage was shown to be dependent on serine 76 phosphorylation. Most importantly, both phosphorylation sites were found to be crucial for p19INK4d function in DNA repair and cell survival. In contrast, serine 76 and threonine 141 were dispensable for CDK4\/6 inhibition highlighting the independence of p19INK4d functions, in agreement with our previous findings. These results constitute the first description of the activation mechanism of p19INK4d in response to genotoxic stress and demonstrate the functional relevance of this activation following DNA damage.","palabras_clave":"DNA DAMAGE|APOPTOSIS|CDK|PKA|CELL CYCLE|INK4"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89293,"idioma_id":5,"titulo":"Evaluación perceptivo-auditiva de voces degradadas y su correlación con medidas acústicas","resumen":"El objetivo es determinar utilizando las mediciones acústicas, qué información es más relevante para el oyente al momento de categorizar el grado general de disfonía. Se eligieron 8 (4 voces femeninas y 4 voces masculinas. Cada emisión fue evaluada auditivo perceptualmente a través del item G de la escala GRBAS por 10 oyentes experimentados y acústicamente mediante medidas de aperiodicidad, ruido y caos. El estudio estadístico de análisis discriminante señala la importancia de GNE, Jit y Jitter_cc y Lyapunov como parámetros predictores del grado general de disfonía. La aplicación del método k-means evidencia que existen rasgos en los parámetros acústicos empleados que permiten agrupar objetivamente las voces estudiadas  con 100% de precisión para la clase 0, 96% a la clase 2 y 79% a la clase 3. Un mayor número y variabilidad de casos se necesita a fin de verificar los resultados preliminares.                               ","palabras_clave":"DESÓRDENS VOCALES|ANÁLISIS ACÚSTICO|ANÁLISIS PERCEPTIVO-AUDITIVO|GRBAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89294,"idioma_id":4,"titulo":"Cyclic organic peroxides thermal decomposition in the presence of CuFe2O4 magnetic nanoparticles","resumen":"The effect of magnetically recoverable CuFe2O4nanoparticles on thermaldecomposition of acetone and pinacolone cyclicorganic diperoxides, and acetone triperoxide was studied. Ethanol, toluene or ethylbenzene were used as reaction solvents, the initial peroxide concentration was ca. 0.02 mol L&#8722;1 and the amount of heterogeneous catalyst added was ca. 0.5 mg mL&#8722;1. CuFe2O4nanoparticles, obtained according to the citric acid-aided process, greatly accelerates the thermaldecomposition of methyl substituted cyclicperoxide, but in the case of pinacolone diperoxide only slightly catalytic effects can be detected, probably due to the presence of the bulky tert-butyl substituent in the proximity of the OO bond. This heterogeneously catalyzed reaction can be explained by a free radical mechanism which involves the initiation reaction on the catalyst surface. The products detected (ethane, 2,2-dimethylpropane, ethylbenzene, bibenzyl and 2,3-diphenylbutane) can be interpreted in terms of the initial OO bond homolysis catalyzed by copper ferrites to form an iron peroxo radical species which later undergoes CO and CC bond cleavage. The reduction of the reaction temperature in the styrene and methylmethacrylate polymerization processes could be the main application of the results obtained in the present work, where the thermaldecomposition of multifunctional cyclicperoxides in the presence of copper ferrites can be reached decreasing the working temperatures.","palabras_clave":"Diperoxides|Triperoxides|Catalytic decomposition|Heterogeneous catalysis|Ferrites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89295,"idioma_id":4,"titulo":"Longitudinal analysis of the 5'UTR, E2-PePHD and NS5A-PKRBD genomic regions of hepatitis C virus genotype 1a in association with the response to peginterferon and ribavirin therapy in HIV-coinfected patients","resumen":"BACKGROUND:The rate of non-response to pegylated interferon plus ribavirin (peg-IFN+RBV) in HCV\/HIV coinfected patients is higher than in HCV-monoinfected patients. In this sense, the contribution of HCV genetic variability is unknown. The 5' untranslated (5'UTR), the nonstructural 5A (NS5A) and the second envelope (E2) HCV genomic regions have been implicated to peg-IFN therapy response. The proteins appear to block interferon (IFN)-induced RNA-dependent protein kinase (PKR) and the 5'UTR may influence the viral lymphotropism.METHODS:We examined comparatively the pretreatment HCV variability between HIV coinfected and HCV monoinfected patients as well as assessed longitudinally the impact of peg-IFN+RBV on HCV variability when HIV is co-present. For this purpose, 15 HIV coinfected and 20 HCV monoinfected patients were compared. They were peg-IFN+RBV non-responders and infected with HCV 1a.RESULTS:Irrespectively of the HIV-coexistence, at baseline the amino acid variation in the NS5A-related domains was significantly higher than in the E2-PePHD (p<0.001). The number of amino acid variations (mean±SD) at the NS5A-ISDR domain was higher among HCV\/HIV patients than HCV-monoinfected ones (1.80±0.77 vs. 0.95±1.05; p=0.009) but such difference was slightly lower when comparing NS5A-PKRBD sequences (2.47±1.13 vs. 1.60±1.57; p=0.06). No differences were found at the E2-PePHD (0±0 vs. 0.2±0.4). At intra-HIV coinfected patient level, only minor (HCV genetic analysis) or no (HCV substitution rate and quasispecies heterogeneity) changes were observed during therapy (basal, 24h, 4weeks, and 12weeks).CONCLUSIONS:Among HCV-1a\/HIV coinfected and HCV-monoinfected peg-IFN+RBV non-responder patients, the HCV variability at the 5'UTR, E2-PePHD and NS5A-PKRBD\/ISDR domains was mostly comparable exhibiting a low number of variations. Four well-defined amino acid substitutions in NS5A-ISDR domain appeared most frequently when HIV coexists. The interferon-based therapy did not exert any effect in the variation, selection or diversity in the above mentioned HCV regions that could influence clinical responsiveness to IFN therapy.","palabras_clave":"5'UTR|E2-PePHD|NS5A-PKRBD|HIV\/HCV coinfection"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89296,"idioma_id":4,"titulo":"A clustering phenomenon among HCV-1a strains among patients coinfected with HIV from Buenos Aires, Argentina","resumen":"The human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share the same transmission routes which lead to high coinfection rates. Among HIV-infected individuals such rates reached 21% in Argentina, being HCV-1a the most predominant subtype. In this work, 25 HCV subtype 1a (HCV-1a) strains from Argentinean patients coinfected with HIV were studied based on E2 and NS5A sequences. Phylogenetic analyses indicated that 12 strains were highly related to each other, constituting a highly supported (posterior probability&#8201;=&#8201;0.95) monophyletic group that we called 'M.' The remaining HCV strains (group dispersed or 'D') were interspersed along the phylogenetic trees. When comparing both groups of HCV-1a, 10 amino acid differences were located in functional domains of E2 and NS5A proteins that appeared to affect eventually the peptides binding to MHC-I molecules thus favoring immune escape and contributing to the divergence of HCV genotypes. Bayesian coalescent analyses for HCV-1a cluster M isolates indicated that the time to the most recent common ancestor (tMRCA) overlaps with the age estimated recently for the HIV-BF epidemic in Argentina. Furthermore, the genomic characterization based on pol gene analysis from HIV viremic patients showed that most HIV isolates from patients coinfected with HCV-1a cluster M were BF recombinants with identical recombination patterns. In conclusion, these results suggest the presence of an HCV-1a monophyletic cluster with a potential HIV co-transmission by phylogenetic analyses.","palabras_clave":"HCV|HIV|Genotype 1"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89297,"idioma_id":4,"titulo":"Comparative analysis of hepatitis B virus genotype a molecular evolution in patients infected with HBV and in patients co-infected with HBV and HIV","resumen":"HIV infection has a significant impact on the natural progression of liver disease caused by infection with hepatitis B virus (HBV), but its role in the molecular evolution of HBV is unknown. It is difficult to study the molecular evolution of HBV longitudinally considering its genomic complexity, which implies the analysis of paired samples. This study aimed to analyze the difference in the evolutionary dynamics of HBV among patients with HIV and uninfected individuals. In this study, 17 patients infected chronically with HBV were recruited, 9 of them were co-infected with HIV. Patients were HBe antigen-positive and infected with HBV genotype A. Paired plasma samples were collected from each patient 3 years apart, and they were compared subsequently to each other. The HBV phylogenetic inference among isolates from patients infected with HBV and co-infected with HBV and HIV tends to cluster separately. Likewise, when comparing the HBV evolutionary rate and genetic distances, values were higher in the former in both preC\/C and S genomic regions. Intra-host analyses of HBV isolates revealed high diversity and complexity of quasispecies among patients infected with HBV exhibiting high numbers of viral variants and genetic distance. In summary, after studying the HBV molecular evolution among isolates ascribed to genotype A at inter- and intra-host levels, HBV exhibited low quasispecies complexity and diversity as well as low evolutionary rates in the presence of HIV co-infection, suggesting that the co-infection may have an impact on the HBV molecular evolution most likely from the weakened cellular immune response.","palabras_clave":"HBV|HIV|EVOLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89298,"idioma_id":5,"titulo":"\u201CDe la fenomenología de la corporeidad a una epistemología del sujeto encarnado\u201D","resumen":"El&nbsp;trabajo presenta un camino reflexivo que va de la fenomenología de la corporeidad, esto es, del descubrimiento del cuerpo propio y de su experiencia, a una epistemología, entendida como una concepción del conocimiento que asume las condiciones de su producción, situación y encarnación, como un aspecto insoslayable en su justificación.&nbsp;Desarrollo en él algunos de los tópicos centrales que jalonan el recorrido propuesto para&nbsp;esbozar lo que entiendo puede ser una epistemología de la subjetividad encarnada. Para ello me propongo comenzaré con una introducción general a la revalorización del lugar del cuerpo en el contexto filosófico del S XX, para luego avanzar en el tratamiento del problema del cuerpo propio y la experiencia del otro en el seno de la fenomenología merleau-pontyana. La filosofía de M. Merleau-Ponty es la inspiración teórica que guía estas reflexiones, de allí la importancia y la necesidad de plantear algunos de sus postulados centrales, en especial su concepción del cuerpo fenomenal y sus reflexiones en torno a la experiencia de la alteridad en el contexto del mundo cultural . Una vez realizado esto paso a tratar la relación entre la fenomenología de la corporeidad y la epistemología de la subjetividad encarnada en virtud de la reconsideración del cuerpo como condición de posibilidad del conocimiento. El trasfondo problemático que subyace a esta exposición es, precisamente, la factibilidad de las ciencias humanas más allá de la canónicas distinciones sujeto-objeto, naturaleza-cultura, materia-conciencia.                                 ","palabras_clave":"FENOMENOLOGIA|EPISTEMOLOGIA|SUBJETIVIDAD|CUERPO PROPIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89299,"idioma_id":4,"titulo":"Bioindication of volatile elements emission by the Puyehue-Cordón Caulle (North Patagonia) volcanic event in 2011","resumen":"            The emission of  volatile pollutants from the volcanic eruption of the Puyehue-Cordón Caulle  complex (North Patagonia Andean Range) that started in June 4th, 2011, was  investigated by bioindication means with the epyphytic fruticose lichen Usnea  sp. The elemental composition of pooled samples made up with 10 lichen thalli  were analysed by Instrumental Neutron Activation Analysis. Eleven sampling  sites were selected within the impacted region at different distance from the  volcanic source. Five sites were selected as they were already sampled in a  previous study prior to the eruption. Two other new sampling sites were  selected from outside the impacted zone to provide non-impacted baseline  sites.The elements associated with the lichen incorporation of particulate  matter (PM) of geological origin were identified by linear correlation with a  geochemical tracer (Sm concentrations). The elements associated with PM uptake  were Ce, Eu, Fe, Hf, La, Lu, Na, Nd, Sb, Sc, Se, Ta, Tb, Th, U, and Yb. Arsenic  and Cs concentrations showed contributions exceeding the PM fraction in sites  near the volcanic centre, also higher than the baseline concentrations, which  could be associated with permanent emissions from the geothermal system of the  Puyehue-Cordón Caulle complex. The lichen concentrations of Ba, Ca, Co, Hg, K,  Rb, Sr, and Zn were not associated with the PM, not showing higher  concentrations in the sites nearby the volcanic source or respect to the  baseline values either. Therefore, there is no indication of the emission of  volatile forms of these elements in the lichen records. The lichen records only  identified Br volatile emissions associated with the Puyehue-Cordón Caulle  complex eruption in 2011  ","palabras_clave":"Lichen|Puyehue-Cordón Caulle volcanic complex|Arsenic|Bromine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89300,"idioma_id":4,"titulo":"Performance of pilot-scale constructed wetlands for secondary treatment of chromium-bearing tannery wastewaters","resumen":"Tannery operations consist of converting raw animal skins into leather through a series of complex waterand chemically-intensive batch processes. Even when conventional primary treatment is supplemented  with chemicals, the wastewater requires some form of biological treatment to enable the safe disposal to the natural environment. Thus, there is a need for the adoption of low cost, reliable, and easy-to-operate alternative secondary treatment processes. This paper reports the findings of two pilot-scale wetlands for the secondary treatment of primary effluents from a full tannery operation in terms of resilience (i.e.,ability to produce consistent effluent quality in spite of variable influent loads) and reliability (i.e., ability to cope with sporadic shock loads) when treating this hazardous effluent. Areal mass removal rates of 77.1 g COD\/m2\/d, 11 g TSS\/m2\/d, and 53 mg Cr\/m2\/d were achieved with a simple gravity-flow horizontal subsurface flow unit operating at hydraulic loading rates of as much as 10 cm\/d. Based on the findings, a  full-scale wetland was sized to treat all the effluent from the tannery requiring 68% more land than would have been assumed based on literature values. Constructed wetlands can offer treatment plant resilience for minimum operational input and reliable effluent quality when biologically treating primary effluents from tannery operations.","palabras_clave":"horizontal flow constructed wetlands|chromium|anaerobic|solids|sizing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89301,"idioma_id":5,"titulo":"Parámetros micrográficos para la identificación de leño, corteza y hoja de Quassia amara L. (Simaroubaceae)","resumen":"Quassia amara L.popularly known as 'quasia', is a shrubby plant from Tropical America. The wood, bark and leave are used in either folk medicine or in procuring phytotherapeutic drugs. The aim of the present work was to analize morphoanatomical and micrographic features which might provide assistance in the identification, analysis and standardization of Quasia amara L wood, bark and leaves. Results. Anatomical study showed white yellowish and diffuse porous wood, confluent paratracheal parenchyma. Rays width 1 cell wide and 8-30 cells high. CaOx crystals are absent. Cortex, 1-4 mm thick, a periderm up to 12 layers phellem cells. Leaf, hipostomatic with dorsiventral mesophyll and high number of sclerosed idioblasts. ","palabras_clave":"QUASSIA AMARA|PARÁMETROS MICROGRÁFICOS|MADERA|CORTEZA|HOJA."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89302,"idioma_id":5,"titulo":"Preparación y caracterización de materiales catalíticos para ser empleados en la producción de biodiesel","resumen":"&lt;!-- \/* Style Definitions *\/ p.MsoNormal, li.MsoNormal, div.MsoNormal\t{mso-style-parent:'';\tmargin:0cm;\tmargin-bottom:.0001pt;\tmso-pagination:widow-orphan;\tfont-size:12.0pt;\tfont-family:'Times New Roman';\tmso-fareast-font-family:'Times New Roman';}p.CM3, li.CM3, div.CM3\t{mso-style-name:CM3;\tmso-style-next:Normal;\tmargin-top:0cm;\tmargin-right:0cm;\tmargin-bottom:11.4pt;\tmargin-left:0cm;\tmso-pagination:widow-orphan;\tmso-layout-grid-align:none;\ttext-autospace:none;\tfont-size:12.0pt;\tfont-family:'Times New Roman';\tmso-fareast-font-family:'Times New Roman';}@page Section1\t{size:612.0pt 792.0pt;\tmargin:70.85pt 3.0cm 70.85pt 3.0cm;\tmso-header-margin:36.0pt;\tmso-footer-margin:36.0pt;\tmso-paper-source:0;}div.Section1\t{page:Section1;}--&gt;La obtención de biodiesel a partir de catálisisheterogénea permite simplificar la separación de los productos deseados yreduce la cantidad de efluentes líquidos generados en el proceso. Ademásprotege a los equipos e instalaciones del ataque de los ácidos o basesconvencionales.En un principio se prepararon catalizadoresácido\/base en zeolitas tipo&nbsp; ZSM-5 yZSM-11.Los distintos catalizadores se caracterizaron mediante técnicas fisicoquímicas:medición de área superficial por el método BET, acidez determinada por FTIR,DRX&nbsp; y TG-DTG. Se desarrollarán técnicaspara determinar el grado de conversión del aceite en biodiesel (TLC, CG y HPLC).El primero sistema de reacción será un sistema del tipo discontinuo, en el cualse evaluarán distintas variables como tipo y cantidad de catalizador,temperatura de reacción, relación metanol\/aceite y tiempo de reacción. Elsegundo sistema será continuo y se evaluará la influencia de la temperatura,tipo y cantidad de catalizador y caudales de alimentación. ","palabras_clave":"Biodiesel|Catálisis heterogénea |Zeolitas|Heteropoliácidos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89303,"idioma_id":4,"titulo":"Cloning and sequencing analysis of Bufo arenarum oviductin cDNA and detection of its orthologous gene expression in the mouse female reproductive tract.","resumen":"The glycoprotein envelope surrounding the Bufo arenarum egg exists in different functional forms. Conversion between types involves proteolysis of specific envelope glycoproteins. When the egg is released from the ovary, the envelope cannot be penetrated by sperm. Conversion to a penetrable state occurs during passage through the pars recta portion of the oviduct, where oviductin, a serine protease with trypsin-like substrate specificity, hydrolyzes two kinds of envelope glycoproteins: gp84 and gp55. The nucleotide sequence of a 3,203 bp B. arenarum oviductin cDNA was obtained. Deduced amino acid sequence showed a complete open reading frame encoding 980 amino acids. B. arenarum oviductin is a multi-domain protein with a protease domain at the N-terminal region followed by two CUB domains and toward the C-terminal region another protease domain, which lacked an active histidine site, and one CUB domain. Expression of ovochymase 2, the mammalian orthologous of amphibian oviductin, was assayed in mouse female reproductive tract. Ovochymase 2 mRNA was unnoticeable in the mouse oviduct but expression was remarkable in the uterus. Phylogenetic relationship between oviductin and ovochymase 2 opens the possibility to understand the role of this enzyme in mammalian reproduction.","palabras_clave":"BUFO ARENARUM|OVIDUCT|OVIDUCTIN|OVOCHYMASE 2|SERINE PROTEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89304,"idioma_id":4,"titulo":"TDR Targets: a chemogenomics resource for neglected diseases","resumen":"The TDR Targets Database (http:\/\/tdrtargets.org) has been designed and developed as an online resource to facilitate the rapid identification and prioritization of molecular targets for drug development, focusing on pathogens responsible for neglected human diseases. The database integrates pathogen specific genomic information with functional data (e.g., expression, phylogeny, essentiality) for genes collected from various sources, including literature curation.  This information can be browsed and queried using an extensive web interface with functionalities for combining, saving, exporting and sharing the query results.  Target genes can be ranked and prioritised using numerical weights assigned to the criteria used for querying.  In this report we describe recent updates to the TDR Targets database, including the addition of new genomes (specifically helminths), and integration of chemical structure, property and bioactivity information for biological ligands, drugs and inhibitors, and cheminformatic tools for querying and visualizing these chemical data. These changes greatly facilitate exploration of linkages (both known and predicted) between genes and small molecules, yielding insight into whether particular proteins may be druggable, effectively allowing the navigation of chemical space in a genomics context.","palabras_clave":"drug discovery|tropical diseases|chemogenomics|bioinformatics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89305,"idioma_id":4,"titulo":"Diagnostic Peptide Discovery: Prioritization of Pathogen Diagnostic Markers Using Multiple Features","resumen":"The availability of complete pathogen genomes has renewed interest in  the development of diagnostics for infectious diseases.  Synthetic  peptide microarrays provide a rapid, high-throughput platform for  immunological testing of potential B-cell epitopes. However, their  current capacity prevent the experimental screening of complete  ``peptidomes´´.  Therefore, computational approaches for prediction and\/or  prioritization of diagnostically relevant peptides are required. In this  work we describe a computational method to assess a defined set of  molecular properties for each potential diagnostic target in a reference  genome. Properties such as sub-cellular localization or expression level  were evaluated for the whole protein. At a higher resolution (short  peptides), we assessed a set of local properties, such as repetitive  motifs, disorder (structured vs natively unstructured regions),  trans-membrane spans, genetic polymorphisms (conserved vs. divergent  regions), predicted B-cell epitopes, and sequence similarity against  human proteins and other potential cross-reacting species (e.g. other  pathogens endemic in overlapping geographical locations). A scoring  function based on these different features was developed, and used to  rank all peptides from a large eukaryotic pathogen proteome.  We applied  this method to the identification of candidate diagnostic peptides in  the protozoan Trypanosoma cruzi, the causative agent of Chagas disease.  We measured the performance of the method by analyzing the enrichment of  validated antigens in the high-scoring top of the ranking. Based on this  measure, our integrative method outperformed alternative prioritizations  based on individual properties (such as B-cell epitope predictors  alone). Using this method we ranked ~10 million 12-mer overlapping  peptides derived from the complete T. cruzi proteome. Experimental  screening of 190 high-scoring peptides allowed the identification of 37  novel epitopes with diagnostic potential, while none of the low scoring  peptides showed significant reactivity. Many of the metrics employed are  dependent on standard bioinformatic tools and data, so the method can be  easily extended to other pathogen genomes.","palabras_clave":"Pathogen genomes|epitope mapping|Diagnostic antigens|Predictitive Algorithms"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89306,"idioma_id":5,"titulo":"Notas descoloniales sobre la escritura de Fanon","resumen":"El trabajo se enfoca en el análisis de las contribuciones que realizó Frantz Fanon para entender la complejidad política y cultural del colonialismo y los procesos de alienación que supone en la dimensión productiva de subjetividad. Desde nuestra perspectiva, la escritura de Fanon constituye una fuente clave para explicar la genealogía de los  movimientos teóricos y políticos que constituyen el giro descolonial. Al mismo tiempo, sugerimos, se ofrece como una referencia insoslayable a la hora de problematizar articulaciones conceptuales que guían casos de estudio donde está comprometida la noción misma de colonialidad, en sus distintas constituciones. El desarrollo de una analítica de la subjetividad colonial subalterna en Fanon permite discutir críticamente las relaciones entre conceptos como los de independencia, liberación y desalienación que circulan con notable frecuencia en ese amplio espectro que constituye el pensamiento latinoamericano.","palabras_clave":"FANON|DESCOLONIAL|ALIENACION|LATINOAMERICANO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89307,"idioma_id":4,"titulo":"1,2,4-Triazole D-ribose derivatives: Design, synthesis and antitumoral evaluation","resumen":"Herein we report the design, synthesis and characterization of novel 1,2,4-triazole D-ribose derivatives, aswell as their synthetic precursors.The antitumoral activity against T cell lymphoma cell line of these products was studied. Structurescontaining a 1,2,4-triazolic ring linked by sulfur to the carbohydrate moiety showed a moderate antiproliferative activity. The presence of the second heterocyclic ring did not show significant changes in their biological activity. Meanwhile, structures with 3-thiobenzyl-5-substituted-1,2,4-triazole ring linked by nitrogen leads to compounds with a biphasic behavior, stimulating cell proliferation at low concentrations and inhibiting it at higher ones. An increment in the polarity was associated with a decrease in the activity of the evaluated compounds.A preliminary antitumoral screening pointed the 1,2,4-triazolic structures linked to protected sugars as promising leaders for further studies.","palabras_clave":"1,2,4-TRIAZOLE|ISOXAZOLINE|D-RIBOSE|ANTITUMORAL ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89308,"idioma_id":5,"titulo":"LMRE: Un entorno multiprocesador para la enseñanza de conceptos de concurrencia en un curso CS1","resumen":"Se presenta un entorno visual interactivo para la enseñanza de conceptos de concurrencia y paralelismo en un curso inicial de algoritmos. El entorno LMRE (Lidi MultiRobot Environment) es una evolución del Visual Da Vinci utilizado extensamente en la introducción a la programación en varias Universidades. El artículo analiza la problemática del cambio tecnológico a partir de la introducción de los procesadores de múltiples núcleos y su impacto sobre la programación y describe una definición del entorno, así como las primitivas a utilizar en la programación de aplicaciones concurrentes. Por último se detallan aspectos de implementación del prototipo actualmente en prueba, así como la evolución del mismo para ser empleado en cursos más avanzados de concurrencia.","palabras_clave":"MULTIROBOT|CONCURRENCIA|PARALELISMO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89309,"idioma_id":4,"titulo":"SMCV: a Methodology for Detecting Transient Faults in Multicore Clusters","resumen":"The challenge of improving the performance of current processors is achieved by increasing the integration scale. This carries a growing vulnerability to transient faults, which increase their impact on multicore clusters running large scientific parallel applications. The requirement for enhancing the reliability of these systems, coupled with the high cost of rerunning the application from the beginning, create the motivation for having specific software strategies for the target systems. This paper introduces SMCV, which is a fully distributed technique that provides fault detection for message-passing parallel applications, by validating the contents of the messages to be sent, preventing the transmission of errors to other processes and leveraging the intrinsic hardware redundancy of the multicore. SMCV achieves a wide robustness against transient faults with a reduced overhead, and accomplishes a trade-off between moderate detection latency and low additional workload.&nbsp;","palabras_clave":"transient fault|silent data corruption|multicore cluster|parallel scientific application|soft error detection|message content validation|reliability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89310,"idioma_id":4,"titulo":"MODIFICATION OF THE PERFORMANCE OF WO3 -ZrO2  CATALYSTS BY METAL ADDITION IN  HYDROCARBON REACTIONS","resumen":"A study of the different hydrocarbon reactions over Ni doped WO3-ZrO2 catalysts was performed. Ni was found as NiO at low Ni concentration while at high Ni concentrations a small fraction was present as a metal. For both cases, Ni strongly modified total acidity and concentration of strong acid sites. In the cyclohexane dehydrogenation reaction, Ni addition promotes both benzene and methyl cyclopentane production. The hydroconversion activity (n-butane and n-octane) increases with the augment of total acidity produced by Ni. The selectivity to reaction products is modified according to the acid strength distribution changes produced by Ni addition. ","palabras_clave":"tungstated zirconia|Ni addition|hydrocarbon reactions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89311,"idioma_id":5,"titulo":"La 'nueva filosofía de la ciencia' y la 'concepción semántica de las teorías científicas' en la didáctica de las ciencias naturales","resumen":"Integración de las corrientes epistemológicas 'nueva filosofía de la ciencia' y 'concepción semántica de las teorías científicas' en el campo de la didáctica de las ciencias naturales.","palabras_clave":"EPISTEMOLOGÍA|NUEVA FILOSOFÍA DE LA CIENCIA|FAMILIA SEMANTICISTA|EDUCACIÓN CIENTÍFICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89312,"idioma_id":4,"titulo":"LOCAL INFLUENCE IN COMPOUND-POISSON MODELS: PERTURBING THE MEAN-VARIANCE RELATION","resumen":"Local influence is a useful tool to detect abnormalities in regression models, Cook proposed this method in 1986 for classical regression models and, since then, numerous extensions have been developed. The aim of this paper is to derive methods to asses local influence under various perturbation schemes, for compound-Poisson regression models. These models can be applied to continuous data with positive probability in zero, and they are characterized by the variance function that defines the mean-variance relationship. Formulas are obtained to apply local influence methods for different perturbations and it is of particular interest the perturbation of the parameter that defines the mean-variance relation. These schemes are applied to perturbed data generated by simulations and the sensibility of the method is compared for different values of the parameters. Finally, a real data set about home expenditures is analyzed and local influence graphics are obtained to detect influential points.","palabras_clave":"compound-Poisson model|local influence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89313,"idioma_id":4,"titulo":"Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose Rich Diet","resumen":"The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype. We studied the impact of FRD administration to mothers on pregnancy outcome. On gestational day (Gd) zero rats were assigned to either group: ad libitum drinking tap water alone (normal diet, ND) or containing fructose (10% w\/vol; FRD) through pregnancy; all rats were fed a Purina chow diet ad libitum ND and FRD rats were daily cotreated or not with metformin (60&#8201;mg\/Kg\/day oral; ND + MF and FRD + MF) and submitted to a high glucose load test on Gd 14. Additionally, placentas from different groups were studied on Gd 20. Data indicated that: (1) although FRD rats well tolerated glucose overload, their circulating levels of insulin were significantly higher than in ND rats; (2) the mesometrial triangle blood vessel area was significantly lower in placentas from FRD than ND dams; (3) the detrimental effects of FRD administration to mothers were ameliorated by metformin cotreatment. Our study suggests that excessive intake of fructose during pregnancy enhanced the risk for developing gestational diabetes and subsequent preeclampsia, and that metformin prevented the poor pregnancy outcome induced by FRD.","palabras_clave":"Angiogénesis|Dietas Modernas|Insulino Sensibilidad|Placenta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89314,"idioma_id":4,"titulo":"Inhibitory Receptors Are Expressed by Trypanosoma cruzi-Specific Effector T Cells and in Hearts of Subjects with Chronic Chagas Disease","resumen":"We had formerly demonstrated that subjects chronically infected withTrypanosoma cruzi show impaired T cell responses closely linked with a process of T cell exhaustion. Recently, the expression of several inhibitory receptors has been associated with T cell dysfunction and exhaustion. In this study, we have examined the expression of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the leukocyte immunoglobulin like receptor 1 (LIR-1) by peripheral T. cruzi antigen-responsive IFN-gamma (IFN-&#947;)-producing and total T cells from chronically T. cruzi-infected subjects with different clinical forms of the disease. CTAL-4 expression was also evaluated in heart tissue sections from subjects with severe myocarditis. The majority of IFN-&#947;-producing CD4+ T cells responsive to a parasite lysate preparation were found to express CTLA-4 but considerably lower frequencies express LIR-1, irrespective of the clinical status of the donor. Conversely, few IFN-&#947;-producing T cells responsive to tetanus and diphtheria toxoids expressed CTLA-4 and LIR-1. Polyclonal stimulation with anti-CD3 antibodies induced higher frequencies of CD4+CTAL-4+ T cells in patients with severe heart disease than in asymptomatic subjects. Ligation of CTLA-4 and LIR-1 with their agonistic antibodies, in vitro, reduces IFN-&#947; production. Conversely, CTLA-4 blockade did not improved IFN-&#947; production in response to T. cruzi antigens. Subjects with chronic T. cruzi infection had increased numbers of CD4+LIR-1+ among total peripheral blood mononuclear cells, relative to uninfected individuals and these numbers decreased after treatment with benznidazole. CTLA-4 was also expressed by CD3+ T lymphocytes infiltrating heart tissues from chronically infected subjects with severe myocarditis. These findings support the conclusion that persistent infection with T. cruzi leads to the upregulation of inhibitory receptors which could alter parasite specific T cell responses in the chronic phase of Chagas disease.","palabras_clave":"TRYPANOSOMA CRUZI|CTLA-4"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89315,"idioma_id":4,"titulo":"Effects of the GnRH antagonist acyline on the testis of the domestic cat (Felis catus)","resumen":"The aim of this study was to describe the effects of a   single dose of the gonadotrophin releasing hormone (GnRH) antagonist   acyline on testicular characteristics of the domestic cat. Twelve mature   cats were orchidectomised unilaterally (right testis) on Day -7 (n&nbsp;=&nbsp;7) or Day 15 (n&nbsp;=&nbsp;5). On Day 0, 330&nbsp;&#956;g\/kg acyline was administered SC to all the animals. Left orchidectomy was carried out on Day 15 (n&nbsp;=&nbsp;2), Day 30 (n&nbsp;=&nbsp;4) and Day 60 (n&nbsp;=&nbsp;6). Sperm were recovered from the epididymis and the testes were evaluated grossly, histologically and immunohistochemically.        Significant differences (P&nbsp;&lt;&nbsp;0.05)   were found between days for epididymal sperm motility, vigor, abnormal   morphology, germinal epithelium height, spermatocytes, spermatids,   spermatozoa, lumen and cellular debris. Conversely, no significant   differences were found for gross testicular and tubular characteristics,   spermatogonia, Sertoli and Leydig cells and intertubular compartments.   It was concluded that a single dose of acyline reversibly impaired   spermiogenesis, spermatocytogenesis and sperm motility for 2&nbsp;weeks.","palabras_clave":"Feline|GnRH analogs|Testicular histology|Acyline"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89316,"idioma_id":4,"titulo":"Unilateral orchidectomy in mature cats is not followed by compensatory hypertrophy","resumen":"The aim of this study was to describe the effect of unilateral orchidectomy on testicular characteristics of mature domestic cats. Five, 1- to 2-year-old, cross-bred male cats were unilaterally orchidectomized on day 0 (right) and day 60 (left). The testes were processed for histological and immunohistochemical evaluation and groups compared by Student?s t-test. No significant differences (p &gt; 0.05) were found between testes groups for any of the gross (volume and gonadosomatic index) and microscopic (tubular diameters, axis, area, length and perimeter, germinal epithelium height, spermatogonias, spermatocytes, spermatids, spermatozoa, Sertoli and Leydig cells, intertubular compartment, lumen, cellular debris, tubular- intertubular proportion and basement membrane) parameters assessed. According to these biometric and morphometric results, mature cats do not develop compensatory hypertrophy within 60 days of unilateral orchidectomy.t-test. No significant differences (p &gt; 0.05) were found between testes groups for any of the gross (volume and gonadosomatic index) and microscopic (tubular diameters, axis, area, length and perimeter, germinal epithelium height, spermatogonias, spermatocytes, spermatids, spermatozoa, Sertoli and Leydig cells, intertubular compartment, lumen, cellular debris, tubular- intertubular proportion and basement membrane) parameters assessed. According to these biometric and morphometric results, mature cats do not develop compensatory hypertrophy within 60 days of unilateral orchidectomy.","palabras_clave":"Unilateral Orchidectomy|Cats|Compensatory Hypertrophy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89317,"idioma_id":4,"titulo":"Frequency of virulence genes of Escherichia coli among newborn piglets from an intensive pig farm in Argentina","resumen":"The enterotoxigenic and porcine enteropathogenic strains of Escherichia coli (ETEC and PEPEC) are agents associated with swine neonatal diarrhea, causing economic losses in swine production. The main goal of this study was to identify virulence genes of E. coli ETEC, verotoxigenic (VTEC) and PEPEC in intestinal strains responsible for swine diseases, by molecular typing using PCR in newborn piglets from an intensive  farm system. Two hundred and sixty seven rectal swabbings from 7-15 day- old Landrace x Large White crossbred piglets were taken, and 123 randomly selected samples, biochemically compatible with E. coli, were tested for E. coli virulence genes by PCR. A frequency (%) compatible with: 68 ETEC, 24 VTEC, and 8 EPEC were found. Of all E. coli strains studied, 19.51 % carried at least one virulence gene. These data showed conclusively that, in spite of the application of strict sanitary measures in the intensive farm, genes encoding virulence factors of intestinal pathogens compatible with ETEC are still detected; therefore these strains will probably keep circulating among animals.","palabras_clave":"VIRULENCE GENES|ESCHERICHIA COLI|PIGLETS|INTENSIVE FARM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89318,"idioma_id":5,"titulo":"Plantas y hongos tintóreos de los wichís del Gran Chaco","resumen":"Se presentan los resultados de una investigación etnobotánica que trata los tintes vegetales y fúngicos entre los indígenas wichí del Chaco Semiárido. Se realizaron trabajos de campo con informantes calificados y ocasionales de ambos sexos en localidades de las provincias argentinas de Salta y Formosa. Asimismo, se hizo una revisión minuciosa de la bibliografía vinculada con el tema. Se encontraron 24 especies de plantas y 2 de hongos que son usadas para colorear productos textiles realizados a partir de fibras de cháguar (Bromelia hieronymi y B. urbaniana). Se proporcionan informaciones y detalles sobre los nombres vernáculos de las especies, las partes usadas, los procedimientos de tinción y los colores logrados. El número total de plantas tintóreas encontrado es alto comparado con los que fueron citados para otras etnias chaquenses y se registraron especies que antes no fueron mencionadas como tintóreas entre los wichís.","palabras_clave":"TINTURAS VEGETALES|ETNOBOTÁNICA|BOTÁNICA ECONÓMICA|ARTE TEXTIL|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89319,"idioma_id":4,"titulo":"Tide and wind forced near-shore dynamics in Nuevo Gulf (Northern Patagonia, Argentina): potential implications for cross-shore transport","resumen":"The coastal hydrodynamics of an eastward-facing bay (Nueva Bay) located in the west coast of Nuevo Gulf (42.76° S, 65.03° W) was inferred using time series of seawater temperature, winds and tides. Temperature was measured at surface and near the bottom at a station with a maximum depth of 18&nbsp;m. Concurrent observations of wind intensity and direction were registered at ~&nbsp;3&nbsp;km from the station. Tidal levels were predicted using the WXTide software. Surface heat flux explained the observed annual cycle of seawater temperature and the seasonal thermal stratification. Events of upwelling\/downwelling were observed associated to offshore\/onshore winds, with lags of approximately 5\u20136&nbsp;hours. Spectral analysis of the temperature time series showed significant diurnal and semidiurnal peaks during the warm season (spring and summer), when the water column was stratified. The semidiurnal peaks of spectral energy were correlated with the main components of the tidal cycle. Diurnal thermal variability was driven by diurnal cycles of wind (sea breeze) occurring during 52% of spring days and 61% of summer days. We present two conceptual models of nearshore dynamics that are coherent with the observed thermal variability (up to 4&nbsp;°C in 6&nbsp;hours).","palabras_clave":"NEARSHORE DYNAMICS|SEA BREEZE|DIURNAL CYCLES|CROSS-SHORE TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89320,"idioma_id":4,"titulo":"Early distal axonopathy of the visual pathway in experimental diabetes.","resumen":"Diabetic retinopathy is a leading causeof acquired blindness. Visual function disorders have been observed in diabeticpatients with very early retinopathy or even before the onset of retinopathy.The aim of the present work was to analyze the visual pathway in an early stageof experimental diabetes. Diabetes was induced in Wistar rats by an i.p.injection of streptozotocin. A deficit in anterograde transport from the retinato the superior colliculus was observed 6 weeks after streptozotocin injection.At this time point, morphologic studies did not reveal retinal ganglion cellloss or substantial alterations in the superior colliculus. The optic nerve wasmorphometrically evaluated at intraorbital (unmyelinated and myelinated) andintracranial sections. In animals that had been diabetic for 6 weeks, a largeincrease in astrocyte reactivity occurred in the distal (but not theintraorbital) portion, which coincided with significant axon loss. Moreover,profound myelin alterations and altered morphologic features of oligodendrocytelineage were observed at the distal (but not the proximal) optic nerve portion.The present results suggest that axoglial alterations at the distal portion ofthe optic nerve could be the first structural change in the diabetic visualpathway.","palabras_clave":"DIABETIC RETINOPATHY|VISUAL PATHWAY|ANTEROGRADE TRANSPORT|OPTIC NERVE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89321,"idioma_id":4,"titulo":"Intranasal administration of aTf protects and repairs the neonatal white matter after a cerebral hypoxic-ischemic event","resumen":"ABSTRACTOur previous studies showed that the intracerebral injectionof apotransferrin (aTf) attenuates white matter damage andaccelerates the remyelination process in a neonatal rat modelof cerebral hypoxia-ischemia (HI) injury. However, the intracerebralinjection of aTf might not be practical for clinicaltreatments. Therefore, the development of less invasive techniquescapable of delivering aTf to the central nervous systemwould clearly aid in its effective clinical use. In thiswork, we have determined whether intranasal (iN) administrationof human aTf provides neuroprotection to the neonatalmouse brain following a cerebral hypoxic?ischemic event.Apotransferrin was infused into the naris of neonatal miceand the HI insult was induced by right common carotid arteryligation followed by exposure to low oxygen concentration.Our results showed that aTf was successfully deliveredinto the neonatal HI brain and detected in the olfactory bulb,forebrain and posterior brain 30 min after inhalation. Thistreatment successfully reduced white matter damage, neuronalloss and astrogliosis in different brain regions andenhanced the proliferation and survival of oligodendroglialprogenitor cells (OPCs) in the subventricular zone and corpuscallosum (CC). Additionally, using an in vitro hypoxicmodel, we demonstrated that aTf prevents oligodendrocyteprogenitor cell death by promoting their differentiation. Insummary, these data suggest that iN administration of aTfhas the potential to be used for clinical treatment to protectmyelin and to induce remyelination in demyelinatinghypoxic?ischemic events in the neonatal brain.corpuscallosum (CC). Additionally, using an in vitro hypoxicmodel, we demonstrated that aTf prevents oligodendrocyteprogenitor cell death by promoting their differentiation. Insummary, these data suggest that iN administration of aTfhas the potential to be used for clinical treatment to protectmyelin and to induce remyelination in demyelinatinghypoxic?ischemic events in the neonatal brain.(CC). Additionally, using an in vitro hypoxicmodel, we demonstrated that aTf prevents oligodendrocyteprogenitor cell death by promoting their differentiation. Insummary, these data suggest that iN administration of aTfhas the potential to be used for clinical treatment to protectmyelin and to induce remyelination in demyelinatinghypoxic?ischemic events in the neonatal brain.","palabras_clave":"Hypoxia\/Ischemia|Myelin|Oligodendrocytes|Apotransferrin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89322,"idioma_id":4,"titulo":"Ischemic conditioning protects from axoglial alterations of the optic pathway induced by experimental diabetes in rats","resumen":"PLoS One. 2012;7(12):e51966. doi: 10.1371\/journal.pone.0051966. Epub  2012 Dec 20.  Ischemic conditioning protects from axoglial alterations of the optic pathway induced by experimental diabetes in rats.  Fernandez DC, Pasquini LA, Dorfman D, Aldana Marcos HJ, Rosenstein RE.    Source  Laboratory   of Retinal Neurochemistry and Experimental Ophthalmology, Department of   Human Biochemistry, School of Medicine, University of Buenos   Aires\/CEFyBO, CONICET, Buenos Aires, Argentina.    Abstract    Diabetic   retinopathy is a leading cause of blindness. Visual function disorders   have been demonstrated in diabetics even before the onset of   retinopathy. At early stages of experimental diabetes, axoglial   alterations occur at the distal portion of the optic nerve. Although   ischemic conditioning can protect neurons and synaptic terminals against   ischemic damage, there is no information on its ability to protect   axons. We analyzed the effect of ischemic conditioning on the early   axoglial alterations in the distal portion of the optic nerve induced by   experimental diabetes. Diabetes was induced in Wistar rats by an   intraperitoneal injection of streptozotocin. Retinal ischemia was   induced by increasing intraocular pressure to 120 mm Hg for 5 min; this   maneuver started 3 days after streptozotocin injection and was weekly   repeated in one eye, while the contralateral eye was submitted to a sham   procedure. The application of ischemia pulses prevented a deficit in   the anterograde transport from the retina to the superior colliculus, as   well as an increase in astrocyte reactivity, ultraestructural myelin   alterations, and altered morphology of oligodendrocyte lineage in the   optic nerve distal portion at early stages of experimental diabetes.   Ischemia tolerance prevented a significant decrease of retinal glutamine   synthetase activity induced by diabetes. These results suggest that   early vision loss in diabetes could be abated by ischemic conditioning   which preserved axonal function and structure.","palabras_clave":"Diabetic retinopathy|diabetics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89323,"idioma_id":5,"titulo":"Poblaciones de la Estepa Rionegrina: Desafíos de la Economía Social, el Desarrollo Comunitario y la Construcción de Autonomía","resumen":"El presente artículo recorre las actividades de un sector geográfico-poblacional históricamente invisibilizado., ubicado en la población de la estepa rionegrina, situada en la Patagonia argentina. Nuestro objetivo es dar cuenta de la interpelación a esa invisibilidad a partir de la valoración económica de actividades feminizadas, situadas en la producción artesanal. Tomamos como eje de nuestra reflexión a una experiencia comercial y productiva asociativa, el Mercado de la Estepa 'Quimey Piuké'. Mostraremos como, tras una experiencia asociativa se encuentra una fuerte disputa respecto de una mirada económica que históricamente ha ignorado las capacidades y potencialidades implícitas en esta experiencia, llevando a revisar el concepto mismo de economía social.","palabras_clave":"Desarrollo Comunitario|Género|Economía Social|Estepa rionegrina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89324,"idioma_id":4,"titulo":"Effects of Cucumber mosaic virus on yield and yield components of peanut","resumen":"In Argentina, peanut (Arachis hypogaea) is naturally infected by Cucumber mosaic virus (CMV), subgroup II. The study involved the evaluation of the effects on yield and yield components in response to CMV infection at different growth stages: 4-6 developed nodes on the main axis (V4-6), 12-16 developed nodes on the main axis (V12-16) and onset of bloom (R1). The resultsshowed that CMV infection significantly reduces peanut seed yield, mainly due to a severe decrease in seed average weight which declined approximately by 30%, 20% and 11% when the virus was inoculated at V4-6, V12-16 and R1, respectively. The number of pods, seeds, and seeds per pod were affected only when the virus was inoculated at V4-6. The percentage of confectionery peanut was also significantly affected when CMV was inoculated at vegetative crop stages. In addition, seed size and weight\/volume ratio were greatly affected by the virus since the infected plants produced a higher proportion of small seeds. Larger seeds decreased when the plants were infected at earlier growth stages. Finally, infected plants produced a significantly greater number of immature pods than the healthy ones.","palabras_clave":"ARACHIS HYPOGAES|CUCUMOVIRUS|YIELD LOSSES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89325,"idioma_id":5,"titulo":"Estudios de magnetismo de rocas aplicados  a un horizonte edafizado del Cuaternario tardío en Bahía San Sebastián, Isla Grande de Tierra del Fuego, Argentina","resumen":"Se presenta un estudio de magnetismo de rocas realizado en un depósito glacifluvial edafizado, de edad cuaternaria, en Bahía San Sebastián, Tierra del Fuego, Argentina.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Se determinó que la mineralogía magnética dominante en el perfil es magnetita y\/o titanomagnetita tamaño de grano PSD y MD. Se observó una disminución en la concentración de minerales ferrimagnéticos en los niveles pedogenéticos con respecto a los niveles inferiores sin edafizar, similar comportamiento se obtuvo en los perfiles de la región pampeana.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; No se detectó la formación de neominerales de alta coercitividad o magnetita superparamagnetica. La generación de estos minerales se produce en los períodos de sequía, en los cuales los geles amorfos producidos durante la fase húmeda se deshidratan&nbsp; y cristalizan.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; A partir de los resultados se estima &nbsp;que la edafización tuvo lugar en el Estadio Isotópico cálido 18O 5, durante el subestadio 5e.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ","palabras_clave":"Cuaternario|Sedimentos Glacifluviales|Paleosuelo|Paleoclima|magnetismo ambiental"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89326,"idioma_id":4,"titulo":"'Paleomagnetic evidence of earliest Paleocene deformation in Calama (~22°S),northern Chile: Andean-type or ridge-collision tectonics?'","resumen":"A paleomagnetic study from the earliest Paleocene Cerros de Montecristo   Quartz Monzonite and its Jurassic to uppermost Cretaceous host rock   (northern Chile, ~22°S) provided high-temperature, high-coercivity   magnetizations of dominantly reversed polarity. The remanences of the   tilted host rock gave a negative fold-test and are indistinguishable   from the remanences found in the pluton, indicating that the uppermost   Cretaceous rocks underwent deformation before intrusion of the earliest   Paleocene pluton, thus documenting a K\u2013T deformation at the locality.   Although this deformation may be another product of typical subduction-related noncollisional tectonics in the Central Andes, an alternative hypothesis, permitted by plate reconstructions, is that the event was associated with collision of an oceanic plate boundary. This latter hypothesis may also provide a context for several other tectonic events from northern Chile to the Patagonian Andes, wherein deformation would the consequence of a southward migrating triple junction between the latest Maastrichtian and Early Eocene.","palabras_clave":"Paleomagnetic|Earliest Paleocence|Calama"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89327,"idioma_id":4,"titulo":"RHEOLOGICAL PERFORMANCE OF PECTIN ENRICHED PRODUCTS ISOLATED FROM RED BEET (Beta vulgaris L. var. conditiva) THROUGH ALKALINE AND ENZYMATIC TREATMENTS","resumen":"The rheological performance of pectin-enriched products extracted from red beet (Beta vulgaris L. var. conditiva) root by-products was evaluated in the present work. They were extracted through an alkaline pre-treatment with or without a subsequent enzymatic (hemicellulase or cellulase) hydrolysis at pH 5.2.Flow assays performed with 2.00% w\/v-pectin aqueous systems showed pseudoplastic (flow index, nz0.4 or 0.8) or Newtonian (n ¼ 1.0) behaviour after fitting of experimental data to Ostwald\u2019s law, also showing poor thickening effect. When Ca2þ was added to water with the same pectin concentration, true gels developed as confirmed by the mechanical spectra obtained through dynamic assays. Junction zones of homogalacturonan (HG) side chains mediated by Ca2þ were able to build up rigid networks in water.Isolated pectins (2.00% w\/v) were also used to constitute milk model systems. Whole and skimmed milk were used at two different concentrations. Milk systems showed more transient and weaker gel networks when compared to Ca2þ-aqueous systems, and were associated to the formation of a [k-casein\/calcium cross linked low methoxyl pectin] complex dampened by the included milk fat globules.Relaxation spectra of pectinemilk systems were in general extended to large relaxation times (104 s) forall isolated fractions studied, which is typical of structured systems. Since all pectin fractions showedvery similar chemical composition and molecular weight (average value and distribution), it was suggestedthat some differences in the rheological performance of each pectin product came from thedifferent length of arabinans and distribution of rhamnose kinks (RG-I, random coil) as well as from thelength of demethylated HG chains (semi-flexible coils).The results of this research show that the pectin-enriched fractions isolated from red beet root wastesare useful as additives in food formulation.","palabras_clave":"red beet|pectin|alkaline treatment |enzymes|rheology|dairy products"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89328,"idioma_id":4,"titulo":"Microwave inactivation of red beet (Beta vulgaris L. var. conditiva) peroxidase and polyphenoloxidase and the effect of radiation on vegetable tissue quality","resumen":"The inactivation of polyphenoloxidase (PPO) and peroxidase (POX) in red beet by traditional and microwave (MW) blanching was studied. Microwave heating effects on color and texture were also studied.  Red beet subjected to MW blanching for 5 min at 100\u2013200W resulted in large weight losses accompanied by a high degree of shrinking. POX was the more heat resistant enzyme. The 90% destruction (D value) of the activity of both enzymes could be achieved only at 200Wwithin the 5 min frame employed for the tests.  When the samples were immersed in water and both the food sample and the water were submitted to  MW exposure at 250\u2013450Wor variable power with a maximum at 935 W, shrinking was avoided. The D value at 90 C (reference; DTref ) and z could be determined after time\u2013temperature corrections, and it was  observed that, in general, DTref values for POX were smaller than for PPO. The microwave treatment (maximum power: 935 W) designed to provide a similar temperature profile to the one observed for traditional  blanching (immersion in water at 90 C), showed the smallest DTref value for POX inactivation.  All treatments reduced elastic characteristics and changed the color of the tissues showing a shift to blue  mainly in the case of microwave processes.","palabras_clave":"Red beet|Blanching|Microwave|Enzymes|Texture|Color"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89329,"idioma_id":4,"titulo":"Hydrolytic and oxidative stability of L-(+)- ascorbic acid supported in pectin films: influence of the macromolecular structure and calcium presence","resumen":"The hydrolytic and oxidative stability of L-(+)-ascorbic acid (AA) into plasticized pectin films were separately  studied in view of preserving vitamin C activity and\/or to achieve localized antioxidant activity at pharmaceutical and food  interfaces. Films were made with each one of the enzymatically tailored pectins (50%, 70%, and 80% DM; Cameron et al.  Carbohydr. Polym. 2008, 71, 287&#8722;299) or commercial high methoxyl pectin (HMP; 72% DM). Since AA stability was dependent  on water availability in the network, pectin nanostructure affected the AA kinetics. Higher AA retention and lower browning rates  were achieved in HMP films, and calcium presence in them stabilized AA because of higher water immobilization. Air storage did  not change AA decay and browning rates in HMP films, but they significantly increased in Ca-HMP films. It was concluded that  the ability of the polymeric network to immobilize water seems to be the main factor to consider in order to succeed in retaining  AA into film materials.","palabras_clave":"Pectin nanostructure|Edible film|Ascorbic acid|Browning|Water|Hydrolysis|Oxidation|Kinetics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89330,"idioma_id":4,"titulo":"Conceptualizing the e-Learning Assessment Domain using an Ontology Network","resumen":"During the last year, approaches that use ontologies, the backbone of   the Semantic Web technologies, for different purposes in the assessment   domain of e-Learning have emerged. One of these purposes is the use of   ontologies as a mean of providing a structure to guide the automated   design of assessments. The most of the approaches that deal with this   problem have proposed individual ontologies that model only a part of   the assessment domain. The main contribution of this paper is an   ontology network, called AONet, that conceptualizes the e-assessment   domain with the aim of supporting the semi-automatic generation of it.   The main advantage of this network is that it is enriched with rules for   considering not only technical aspects of an assessment but also   pedagogic","palabras_clave":"ontology network|e-learning assessment"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89331,"idioma_id":5,"titulo":"Manual de Ecología. Poblaciones: Introducción a las técnicas para el estudio de las poblaciones silvestres","resumen":"El manual se inicia con una aproximación al estudio de las poblaciones  silvestres. Esta primera parte incluye conceptos sobre los métodos más  difundidos para cuantificar la abundancia de las poblaciones y se  plantean ejercitaciones de las técnicas para la estimación de la  densidad poblacional tanto en campo como en el laboratorio","palabras_clave":"Muestreo|Transectas|Historias de vida|Ecologia de Poblaciones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89332,"idioma_id":5,"titulo":"Manual de Ecología. Poblaciones: demografía, crecimiento e interacciones","resumen":"Este manual aborda y ejercita la construcción de tablas de vida horizontales o dinámicas y tablas de vida verticales o estáticas, y se definen y realizan ejercicios sobre estadísticos y parámetros poblacionales, con el apoyo de planillas de cálculo específicas. Para estudiar los modelos de crecimiento exponencial y logístico se plantean actividades de simulación de crecimiento y fluctuación de abundancia de poblaciones. Se aplican herramientas como el cálculo de elasticidad para el manejo de poblaciones. Un breve desarrollo teórico de conceptos y ejercitaciones sirve de introducción a los modelos clásicos de competencia interespecífica y de depredador-presa de Lotka-Volterra, seguido de actividades de simulación de crecimiento y fluctuación de abundancia de poblaciones. Luego continúa con problemas relacionados con el principio de exclusión competitiva, usando como herramienta un programa de simulación. Se define para cada una de las especies que compiten el tipo de recursos que explotan, la tasa de consumo, la asignación de energía para supervivencia y para reproducción y se plantea como desafío verificar la predicción que se deriva de la hipótesis de exclusión competitiva.","palabras_clave":"Ecología de Poblaciones|Demografía|Tablas de vida|Modelos de Crecimiento"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89333,"idioma_id":5,"titulo":"Manual de Ecología. Evaluación de la biodiversidad","resumen":"Como primera actividad se enseña a cuantificar la Biodiversidad mediante índices de diversidad y modelos de distribución de abundancia de especies, usando bases de datos de comunidades neotropicales. A continuación se plantea un trabajo práctico de campo para discutir la resolución de conflictos que surgen entre el manejo de cuencas hídricas y la conservación de especies. En laboratorio se desarrollan situaciones de simulación basadas en las hipótesis de disturbio intermedio y predador clave. Por último, se propone un trabajo de síntesis sobre el impacto de la actividad urbana sobre la diversidad de aves, que incluye tanto actividades de campo para la colecta de los datos como su análisis y la discusión de los resultados obtenidos.","palabras_clave":"Ecología de Comunidades|Diversidad|Modelos de abundancia|Conservación de la biodiversidad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89334,"idioma_id":5,"titulo":"Manual de Ecología. Dinámica espacial en el manejo de las poblaciones","resumen":"En este módulo se incorpora el componente espacial en el estudio de las poblaciones, en referencia a la conservación y manejo de vida silvestre. Primero se presentan ejercicios para examinar cómo diferentes niveles de fragmentación del paisaje y pérdida de hábitat afectan las tasas de crecimiento de las poblaciones y se discute el concepto de trampas ecológicas. Luego, se propone un ejercicio de simulación sobre un modelo de dinámica de metapoblaciones usando planillas de cálculo. Como cierre, se presentan casos de estudio donde se analiza la problemática de las invasiones biológicas.","palabras_clave":"Ecología del Paisaje|Fragmentacion|Metapoblaciones|Manejo de Poblaciones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89335,"idioma_id":4,"titulo":"Grazing and nutrient effects on a high rocky intertidal of the Peruvian central coast","resumen":"Bottom-up and top-down forces simultaneously influence benthic communities. However, their relative strength may vary with environmental conditions. In the Peruvian coast, the periwinkles are conspicuous grazers able to control both biofilm abundance and barnacle recruitment. Moreover, even in upwelling areas, algae living in the high intertidal may be nutrient-limited. Here we tested, in a nutrient-rich system, the relative effects of grazing and nutrient on the early succession of the high rocky intertidal. For this, we experimentally manipulated grazing and nutrient combined in a completely crossed design. Since nutrient and grazing seem to alter benthic community at different temporal scales, their effects were tested over the long-term (14 months) and the short-term (1 months). Over the long-term, barnacle cover increased throughout time, but was neither affected by grazing nor fertilization. At all sampling times fertilization increased biofilm cover and reduced bare rock, while exclusion of grazers also enhanced biofilm. The effect of grazing on bare rock varied through the succession. Macroalgae reached a maximum cover of 6.88%. Over the short-term, chlorophyll-a content was not affected by nutrient addition but was always higher in plots where grazer were excluded. Our results suggest that biofilm might be nutrient-limited in the high intertidal, despite being located in an upwelling area. However, the effects of grazers and nutrients on the biofilm are not reflected in macroalgae or barnacles, probably because of the occurrence of other structuring factors. In the short-term, grazing seems to have greater effect on biofilm, irrespective of the nutrient level, whereas over the longer-term, biofilm can take advantage of nutrient enhancement only in the absence of grazers","palabras_clave":"BIOFILM|GRAZING|HIGH ROCKY INTERTIDAL|LITTORINID|NUTRIENTS|PERU"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89336,"idioma_id":4,"titulo":"3CaH2+4MgB2+CaF2 Reactive Hydride Composite as a Potential Hydrogen Storage Material: Hydrogenation and Dehydrogenation Pathway","resumen":"A reactive hydride composite (RHC) with initial composition 3CaH2 + 4MgB2 + CaF2 was studied by in situ synchrotron radiation powder X-ray diffraction (SR-PXD) and X-ray absorption near edge structure (XANES) at the B K-edge and at the Ca K-edge. The hydrogenation reaction proceeds by an unknown intermediate. No evidence of intermediates was observed during the dehydrogenation reaction. B and Ca K-edge XANES results hint to a closed interaction of CaF2 and Ca(BH4)2. The main function of CaF2 in the 3CaH2 + 4MgB2 + CaF2 RHC is as a dopant for the hydrogenation and dehydrogenation reactions.","palabras_clave":"Reactive Hydride Composite|Hydrogene Storage|NEXAFS|In situ XRD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89337,"idioma_id":4,"titulo":"NEXAFS study of 2LiF\u2013MgB2 composite","resumen":"Synthesis of lithium borohydridofluorides may pave a new way to pursue improved hydrogen storage properties of LiBH4 as reversible hydrogen storage materials that fit the fuel cell application. The main products of the hydrogen absorption by 2LiF\u2013MgB2 composite are MgF2 and LiBH4. In addition to them, LiBH4&#8722;xFx compounds might be present during hydrogen absorption\u2013desorptions and play important role on their kinetics and reversibility.    First results of Near Edge X-ray Absorption Fine Structure (NEXAFS) at the B K-edge (193 eV) for LiF\u2013MgB2 composite with molar ratio (2:1) are presented. Obtained results indicate a formation of mixed borohydrides\/borofluorides of the type of LiBH4&#8722;xFx, thus suggesting fluorine substituting for hydrogen.","palabras_clave":"Lithium borohydridofluoride|Reactive hydride composite|Substitution of hydrogen|NEXAFS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89338,"idioma_id":4,"titulo":"New Insights into the Chemistry of Thiolate-Protected Palladium  Nanoparticles","resumen":"This paper establishes the chemical nature of Pd nanoparticles protected by alkanethiolates that were prepared through a ligand place-exchange approach and the two-phase method, first developed for Au nanoparticles by Brust and Schiffrin. After 10 years since the first study on this kind of Pd nanoparticles was published, the surface composition of the particles is a matter of debate in the literature and it has not been unambiguously assessed. The nanoparticles were studied by means of several techniques: UV\u2013visible spectroscopy, scanning transmission electron microscopy, Fourier-transform infrared spectroscopy, extended X-ray absorption fine structure, and X-ray photoelectron spectroscopy. The experimental data, obtained for the 3 nm diameter Pd particles, prepared by both synthetic routes, are consistent with nanoparticles composed by Pd(0) cores surrounded by a submonolayer of sulfide species, which are protected by alkanethiolates. Also, we unambiguously demonstrate that the chemical nature of these particles is very similar to that experimentally found for alkanethiolate-modified bulk Pd. The results from this paper are important not only for handling thiolate-protected Pd nanoparticles in catalysis and sensing, but also for the basic comprehension of metallic nanoparticles and the relation of their surface structure with the synthesis method.","palabras_clave":"Thiolate-Protected Palladium Nanoparticles|EXAFS|sulfide species"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89339,"idioma_id":5,"titulo":"Estudio comparativo iberoamericano sobre la participación de la mujer en las actividades de investigación y desarrollo?. Documento de trabajo Nº 42","resumen":"Lasituación de las mujeres en la ciencia se ha transformado en los últimostiempos en un tema de alto&nbsp; interés en las agendas públicas &nbsp;de diversos países del mundo. Se hanmultiplicado los foros de discusión, las redes de intercambio y otrosemprendimientos para su estudio en todo el mundo. En líneas generales observauna&nbsp; creciente presencia femenina entre la población de alta formacióneducativa que aún no &nbsp;alcanza a expresare en su totalidad en la fuerza detrabajo científico pero que evoluciona positivamente. Conel fin de atender este problema se han realizado una serie de estudios de casonacionales en 8 países de la región iberoamericana (Argentina, Brasil, CostaRica, España, México, Paraguay, Uruguay y Venezuela ) en el marco del proyectoGentec, una iniciativa de apoyo al desarrollo de la mujer en la ciencia y latecnología de la UNESCO. Estos estudios fueron realizados en dos fases entre elaño 2002 y el 2003 y dieron lugar a sendos informes que han formado parte de lainformación utilizada en este trabajo . &nbsp;El articulo expone los resultadosdel analisis cuyo propósito &nbsp;central es obtener un primer panorama basadoen la sistematización de las principales estadísticas nacionales y en suanálisis comparativo, procurando detectar en el nivel del conjunto los principalesproblemas detectados para el logro de una mayor equidad de la mujer en laciencia. Se espera que este estudio forme parte de un proceso de más largoalcance dirigido al conocimiento profundo de las características de lapresencia femenina en la ciencia de estas sociedades, que genere explicacionesa este &nbsp;fenómeno y proponga recomendaciones para el logro de la equidad enla ciencia regional  ","palabras_clave":"genero|ciencia |iberoamerica|politica cientifica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89340,"idioma_id":4,"titulo":"Biofouling of crypts of historical and architectural interest at La Plata Cemetery (Argentina)","resumen":"Cemeteries are part of the cultural heritage of urban communities, containing funerary crypts and monuments of historical and architectural interest. Efforts aimed at the conservation of these structures must target not only the abiotic stresses that cause their destruction, such as light and humidity, but also biofouling by biotic agents. The purpose of this study was to assess the development of biofouling of several historically and architecturally valuable crypts at La Plata Cemetery (Argentina). Samples obtained from the biofilms, lichens, and fungal colonies that had developed on the marble surfaces and cement mortar of these crypts were analyzed by conventional microbiological techniques and by scanning electron microscopy. The lichens were identified as Caloplaca austrocitrina, Lecanora albescens, Xanthoparmelia farinosa and Xanthoria candelaria, the fungi as Aspergillus sp., Penicillium sp., Fusarium sp., Candida sp. and Rhodotorula sp., and the bacteria as Bacillus sp. and Pseudomonas sp. The mechanisms by which these microorganisms cause the aesthetic and biochemical deterioration of the crypts are discussed.","palabras_clave":"Cultural Heritage|Funerary monument|Crypt|Marble|Cement|Mortar|Biofouling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89341,"idioma_id":4,"titulo":"An in situ  test  to explore the responses of Scenedesmus acutus and Lepocinclis acus as indicators of the changes in water quality in lowland streams.","resumen":"This bioassay was designed with the aim of exploring the responses of two wild planktonic microalgae exposed in situ (72 h) as indicators of the changes in water quality. Monocultures of both strains within dialysis membrane bags were placed at two sites in a small lowland stream. Site 1 is located at a suburban area with low horticultural activity and Site 2 is impacted by toxic industrial discharges and urban land use.  There was a decrease in population growth of both species at Site 2 compared with Site 1. The comparison of the algae exposed in situ with the normal specimens cultured at the laboratory indicated a significant increase in the cellular volume for both species at both sites. Abnormal shape was recorded at both sites, being the percentage significantly greater for S. acutus at Site 2. Significant changes in pyrenoids size were observed in S. acutus and in the percentage of fragmented nuclei in L. acus. Also in the latter abnormal paramylon grains were observed. These responses were accentuated at Site 2.  This bioassay was sensitive, short term, low cost, and therefore is a suitable tool to contribute with the monitoring and ecological risk assessment of lowland streams.","palabras_clave":"ECOTOXICOLOGY|IN SITU BIOASSAY|MICROALGAE|WATER QUALITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89342,"idioma_id":4,"titulo":"Chromium induced stress conditions in heterotrophic and auxotrophic strains of Euglena gracilis","resumen":"Oxidative stress parameters and antioxidant defense compounds were studied in relation to different Cr(VI) concentrations (0, 10, 20, 40 µM) on two strains of Euglena gracilis, and the modulation of their toxicity by autotrophic and heterotrophic  conditions. One strain isolated from a polluted river (MAT) and the other a commercial one (UTEX) were used for this research.  The highest levels of chromium uptake by autotrophic cultures were reflected on the inhibition on cell proliferation and the lower IC50 levels observed than their heterotrophic strains. A reduction of chlorophyll levels were showed, whereas the ratio protein and paramylon content was augmented due to a higher increase in protein levels over the carbohydrates. Total lipid content was also increased with the treatment presenting the highest values the autotrophic strains. TBARS content was measured as lipid peroxidation index, increasing with 40µM Cr(VI) concentration. Unsaturated fatty acids were increased with the treatment, showing the higher storage lipid (saturated acids) content the heterotrophic cells. The antioxidant responses, such as SOD activity and GSH content increased with the greatest chromium concentration, showing the highest GSH values the heterotrophic cultures.   The main differences between MAT and UTEX were the major values of IC50, the highest carbohydrate and saturated acid contents, and a better response in the antioxidant system, presented by MAT treated strains. This strain showed the highest GSH content and SOD activity not only in control cells but also in almost all treated cultures. SOD activity levels reached 9-fold increased in both MAT strains. These results would suggest that tolerance to Cr(VI) in treated MAT strain not only would be related to GSH levels and\/or biosynthesis capacity, as was observed by other authors, but also the participation of SOD antioxidant enzyme. Chromium toxicity depended on the culture conditions reaching a more efficient defense\/detoxification system the cells cultured in heterotrophic conditions.","palabras_clave":"EUGLENA GRACILIS|OXIDATIVE STRESS|HEXAVALENT CHROMIUM|ANTIOXIDANT DEFENSE|LIPID PEROXIDATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89343,"idioma_id":4,"titulo":"A taxonomic and ultrastructural study of naked Euglenophyta from Colombia","resumen":"A floristic and ultrastructural study on naked green Euglenophyta was performed in the Amazonian and Caribbean regions of Colombia, where a large number of taxa are contained in several freshwater bodies. A total of 37 taxa were recorded, 1 belonging to the genus Cryptoglena Ehr., 9 to Lepocinclis Perty, 1 to Monomorphina Meresch., and 26 to Phacus Duj. From the identifi ed taxa, 22 were recorded for the fi rst time in Colombia, 2 in the Amazonian region, and 14 in the Caribbean region. Among the taxa described in this work we propose Phacus sesquitortus var. longicauda as a new variety. In addition, 9 taxa were examined by scanning electron microscopy (SEM) to illustrate in detail their ultrastructure; 3 of them were examined for the fi rst time under this method.","palabras_clave":"Euglenales|Euglenophyceae|Euglenophyta|freshwater algae|Colombia|taxonomy|ultrastructure|phytoplankton|thychoplankton"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89344,"idioma_id":4,"titulo":"First ocurrence of a Rhabdovirus  infecting maize in Argentina .","resumen":"Se iniciaron los estudios de identificación de un nuevo virus de maize que produce la formación de estrías y bandeado en las hoja , enanismo de las plantas&nbsp; y espigas estériles . Estos síntomas se detectaron en plantas de&nbsp; lotes de las provincias de Buenos Aires ,&nbsp;Santa &nbsp;Fé y Córdoba . Se estudiaron las partículas virales&nbsp; por microscopía electrónica , se trasmitió la enfermedad a traves del Delphacido&nbsp; Peregrinus maidis en forma persistente . Los estudios moleculares permitieron comprobar que este virus que infecta maiz esta muy relacionado con los&nbsp;cytorhabdovirus &nbsp; y muy separado del grupo de los nucleorbabdovirus. Esta es la primera mención de un cytorhabdovirus infectando maiz en Argentina .","palabras_clave":"Rhabdoviridae|Peregrinus maidis| Cytorhabdovirus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89345,"idioma_id":4,"titulo":"Long-term effects of intermittent IL-2 in HIV infection: extended follow-up of the INSIGHT STALWART Study.","resumen":"BACKGROUND:  The Study of Aldesleukin with and without Antiretroviral Therapy (STALWART) was designed to evaluate whether intermittent IL-2 alone or with peri-cycle ART increased CD4+ cell counts (and so delayed initiation of ART) in HIV infected individuals having &#8805; 300 CD4+ cells\/mm(3) compared to untreated controls. When the results of two large clinical trials, ESPRIT and SILCAAT, showed no clinical benefit from IL-2 therapy, IL-2 administration was halted in STALWART. Because IL-2 recipients in STALWART experienced a greater number of opportunistic disease (OD) or death and adverse events (AEs), participants were asked to consent to an extended follow-up phase in order to assess persistence of IL-2 effects.  METHODOLOGY:  Participants in this study were followed for clinical events and AEs every 4 months for 24 months. Unadjusted Cox proportional hazards models were used to summarize death, death or first OD event, and first grade 3 or 4 AE.  PRINCIPAL FINDINGS:  A total of 267 persons were enrolled in STALWART (176 randomized to the IL-2 arms and 91 to the no therapy arm); 142 individuals in the IL-2 group and 80 controls agreed to enter the extended follow-up study. Initiation of continuous ART was delayed in the IL-2 groups, but once started, resulted in similar CD4+ cell and viral load responses compared to controls. The hazard ratios (95% CI) for IL-2 versus control during the extension phase for death or OD, grade 3 or 4 AE, and grade 4 AE were 1.45 (0.38, 5.45), 0.43 (0.24, 1.63) and 0.20 (0.04, 1.03), respectively. The hazard ratios for the AE outcomes were significantly lower during the extension than during the main study.  CONCLUSIONS:  Adverse events associated with IL-2 cycling did not persist upon discontinuation of IL-2. The use of IL-2 did not impact the subsequent response to initiation of cART.","palabras_clave":"HIV|INFECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89346,"idioma_id":4,"titulo":"A putative functional vomeronasal system in anuran tadpoles","resumen":"In the present work we examine the occurrence and anatomy of the vomeronasal system (VNS) in tadpoles of 13 different anuran species. A morphological fully developed VNS is present in all species examined with a highly conserved anatomical organization. A bean-shaped vomeronasal organ (VNO) develops earlier in tadpoles, during final embryonic stages, and localises in the anteromedial nasal region. Histology reveals the presence of bipolar chemosensory neurons in the VNO that are immunoreactive for the Gáo protein. Tack tracing experiments demonstrate that chemosensory neurons from the VNO reach specific areas in the brain, where a clear discernibly accessory olfactory bulb (AOB) can be observed. The AOB was located in the ventrolateral side of the anterior telencephalon, somewhat caudal to the main olfactory bulb. Synaptophisin-like immunodetection reveals that synaptic contact are earlier establishes in the AOB. Moreover, using lectin staining, noticeable glomerular structures were identified in the AOB of most species examined. All together, these data reveals that a significant maturity in the VNS is achieved in anuran larvae. Recent evidence strongly suggests that the VNS appeared earlier in vertebrates? evolution and it&nbsp; would be already present in the aquatic last common ancestor of lungfishes and tetrapods. In this context, tadpoles are exceptional models to investigate anatomical, biochemical, and functional aspect of the VNS in the aquatic environment.","palabras_clave":"CHEMICAL SENSING|PHEROMONES|VOMERONASAL ORGAN|G PROTEIN|ACCESSORY OLFACTORY SYSTEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89347,"idioma_id":4,"titulo":"NEUTRALIZATION OF EARLY PREGNANCY FACTOR BY PASSIVE IMMUNIZATION ALTERS NORMAL EMBRYONIC DEVELOPMENT AND CYTOKINE BALANCE","resumen":"The aim of this study was to evaluate the effects of passive immunization with polyclonal anti-swine Early Pregnancy Factor (EPF) antibody in pregnant rats during the pre-implantation period, and to analyse the regional distribution of EPF in placenta of rats. The immunodetection of EPF in rat placenta, as well as fertilization, development and immunological parameters, were evaluated. The average number of embryos and the embryo\/corpora lutea ratio of rats treated with anti-EPF antibody were significantly lower than control groups. Also expected, &nbsp;the embryos showed a delay in their development. Further, while IL-10 and INF-ã&nbsp; levels increased, TGF-â decreased significantly in the group treated with anti-EPF in serum and placenta. EPF was present in giant and decidual cells, as well as in blood vessels and trophoblastic lacuna cells, as revealed by positive immunostaining. This study provides new results on the function and location of EPF, and has revealed the usefulness of polyclonal anti-swine EPF antibody. ","palabras_clave":"EARLY PREGNANCY FACTOR|EARLY DEVELOPMENT|CYTOKINES|IMPLANTATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89348,"idioma_id":5,"titulo":"[Pharmacogenomics in gastroenterologic diseases].","resumen":"Pharmacogenomics is the study of genetic variations that produce a modification of the response to drugs. These variations are expressed as a different capacity for the metabolism or the transport of drugs, or a variable activity of drug receptors. Drug use in gastroenterology offers different examples of the use of pharmacogenomic analysis in the identification of the appropriate drug and drug dose for each individual patient. The use of proton pump inhibitors in the treatment of gastroesophagic reflux disease and Helicobacter pylori eradication may be optimized by the analysis of polymorphisms of the CYP2C19 gene. Additionally, the study of variants of IL28 helps in the identification of patients with more chances of response to the treatment of hepatitis C with interferon and ribavirin. The analysis of polymorphisms of the gene coding for the enzyme thiopurine methyl transferase (TPMT) helps in the reduction of the risks associated with the use of azathioprine in the treatment of inflammatory bowel disease. In this way, pharmacogenomics constitute not only a therapeutic tool that already shows an impact in the individualization of drug use in gastroenterology but also a tool with a great projection in the future.","palabras_clave":"Pharmacogenomics |gastroenterologic |diseases"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89349,"idioma_id":4,"titulo":"Prevalence of CYP2C9 and VKORC1 alleles in the Argentine population and implications for prescribing dosages of anticoagulants","resumen":"Dicumarinic oral anticoagulants have a narrow therapeutic range and a great individual variability in response, which makes calculation of the correct dose difficult and critical. Genetic factors involved in this variability include polymorphisms of genes that encode the metabolic enzyme CYP2C9 and the target enzyme vitamin K epoxide reductase complex 1 (VKORC1); these polymorphisms can be associated with reduced enzymatic expression. We examined the frequency of the most relevant variants encoding CYP2C9 (alleles *1, *2 and *3) and VKORC1 (SNP -1639A>G) in the Argentinian population. Molecular typing was performed by PCR-RFLP on a randomly selected sample of 101 healthy volunteers from the Hospital Italiano de Buenos Aires gene bank. Fifty-seven subjects were identified as homozygous for CYP2C9*1 and 14 for *2, while 24 and 5 were heterozygous for *2 and *3 alleles; one individual was a composite heterozygote (*2\/*3). When we examined VKORC1, 21 subjects were AA homozygous, 60 were AG heterozygotes and 20 were GG homozygotes. This is the first analysis of genotypic frequencies for CYP2C9 and VKORC1 performed in an Argentinian population. These allele prevalences are similar to what is known for Caucasian population, reflecting the European ancestor of our patient population, coming mostly from Buenos Aires city and surroundings. Knowledge of this prevalence information is instrumental for cost-effective pharmacogenomic testing in patients undergoing oral anticoagulation treatment.","palabras_clave":"CYP2C9|VKORC1|ANTICOAGULANTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89350,"idioma_id":4,"titulo":"Building an expert system to assist system refactorization","resumen":"The separation of concerns is an important issue in the building of maintenable systems. Aspect oriented programming (AOP) is a software paradigm that allows the encapsulation of those concerns that crosscut a system and can not be modularized using current paradigms such as object-oriented programming. In this way, AOP increases the software modularization and reduces the impact when changes are made in the system. In order to take advantage of the benefits of AOP, the legacy OO systems should be migrated. To migrate object-oriented systems to aspect-oriented ones, specific refactorings for aspects should be used. This is a complex and tedious task for the developer because he\/she needs to know how the refactorings should be applied and under what context. Therefore, it is desirable to have tools that help him\/her through the process. In this article, we present an expert software agent, named RefactoringRecommender, that assists the developer during a refactorization of a system. The agent uses a Markovian algorithm with the goal of predicting the needed restructurings.","palabras_clave":"Interface agents|Expert systems|Aspect-oriented software development|Aspect refactoring"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89351,"idioma_id":4,"titulo":"Geographical distribution and ecological diversification of South American octodontid rodents","resumen":"Caviomorph rodents represent one of the most distinctive groups of mammals in southern South America drylands; they colonized South America from Africa via trans-oceanic dispersions in the Eocene (40?50 Ma) and underwent an extraordinary ecological radiation after their arrival, thus making this group of great interest for biogeographic and evolutionary studies. The aim of this article was to provide a working hypothesis regarding the biogeographical history and ecological diversification of one of its conspicuous families, the Octodontidae. We reconstruct the evolutionary theater where their ecological diversification took place, and potential events of dispersal, vicariance and extinctions. We analyzed the historical biogeography of the Octodontidae across the eight ecoregions where they occur, based on species phylogeny and divergence times. Four approaches were used to reconstruct ancestral area: (1) Statistical Dispersal?Vicariance Snalysis (S-DIVA); (2) Bayesian binary MCMC analysis implemented in Reconstruct Ancestral State in Phylogenies (RASP); (3) Fitch optimization method; and (d) weighted ancestral area analysis (WAAA). Parsimony ancestral state reconstructions were implemented in order to explore the evolutionary history of an ecological character, mode of life. We propose the northern portion of the Monte desert ecoregion as the ancestral area in the evolution of the Octodontidae, with subsequent dispersal and enlargement of the family geographic range. The evolution of their ecological specialization (i.e. modes of life) suggests an ambiguous ancestral condition (saxicolous, generalist terrestrial, semifossorial) linked to species adaptation to arid environments, with fossoriality appearing later in octodontid evolution. The evolution of the Octodontidae is associated with contrasting environmental conditions (i.e. climate and vegetation) produced by the Andean Uplift between eastern and western sides.","palabras_clave":"South America|Rodents|Historical Biogeography|Diversification"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89352,"idioma_id":4,"titulo":"Diversity and distribution of small mammals in the South American Dry Andes","resumen":"The Andean mountain range has played an important role in the evolution of South American biota. However, there is little understanding of the patterns of species diversity across latitudinal and altitudinal gradients. In this paper, we examine the diversity of small mammals along the South Central Dry Andes (SCDA) within the framework of two contrasting hypotheses: (a) species richness decreases with increasing elevation and latitude; and (b) species richness peaks at altitudinal midpoints (mid-domain).We explore the composition of the species pool, the impact of species?area relationships and the Rapoport effect (i.e. size of geographic ranges) along latitudinal and elevational gradients. First, we constructed a database of SCDA small mammals. Then, species richness patterns were analysed through generalized models, and species?area relationships were assessed by log?log regressions; the curvilinear method (c = S\/Az) was use to compute richness corrected by area size. Lastly, the Rapoport effect was evaluated using the midpoint method. Our results show: (1) a richness of 67 small mammals along the SCDA, of which 36 are endemic; (2) a hump-shaped pattern in species richness along elevation and latitudinal gradients; (3) a species?area relationship for both gradients; (4) endemic species corrected by area present a strong and positive relationship with elevation; (5) a Rapoport effect for the latitudinal ranges, but no effect across the elevational gradient; and (6) a major species turnover between 28° and 30° south latitude. This is the first study quantifying the diversity of small mammals encompassing the central Andean region. Overall, our macrogeographic analysis supports the previously postulated role of the Andes in the diversification of small mammals (i.e. in situ cladogenesis) and highlights some basic attributes (i.e. anatomy of geographic ranges; species?area relationships) when considering the consequences of climate change on biodiversity conservation of mountain ecosystems.","palabras_clave":"ANDEAN ECOREGIONS|MOUNTAINS |RICHNESS|GRADIENTS|SPECIES-AREA RELATIONSHIPS|DISTRIBUTIONAL RANGES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89353,"idioma_id":4,"titulo":"Strategies for enhanced CWPO of phenol solutions","resumen":"The performance of a commercial CuO\/alumina catalyst used in the catalytic wet peroxide oxidation(CWPO) of 1 g\/l phenol solutions is investigated in a batch reactor. The effect of temperature, catalyst load,hydrogen peroxide concentration and dosage strategies on phenol mineralization, hydrogen peroxideconsumption efficiencies and catalyst stability was studied. Experiments were performed at 298, 323and 343 K, using catalyst loads of 1 g\/l or 25 g\/l and concentrations of hydrogen peroxide 1.3, 2.6 and 3.9times the stoichiometric requirement added at once or in distributed doses. The critical goal of the CWPOin terms of Process Intensification is to achieve total phenol mineralization working at optimal hydrogenperoxide consumption efficiencies while retaining catalyst stability. The present work highlights thecomplexity of this objective and shows viable working alternatives.Results indicate that high temperatures and concentrations of catalyst and hydrogen peroxide (addedat once) can be employed when fast mineralization and high pH values are required in order to preventcatalyst leaching, although oxidant consumption efficiencies are then low. However, simultaneoushigh mineralization and hydrogen peroxide consumption efficiencies are obtained with a proper oxidantdosage strategy at high temperature, using high catalyst load. Then, hydrogen peroxide degradation intonon-oxidising (parasitic) species is minimized with final TOC conversions close to 90%. The drawback ofthis strategy is that the rate of reaction is lower because of the limited amount of oxidant available.","palabras_clave":"Phenol CWPO|H2O2 addition|CuO Catalyst"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89354,"idioma_id":4,"titulo":"Mating system and population analysis of the broad-snouted caiman (Caiman latirostris) using microsatellite markers","resumen":"The knowledge about reproductive strategies of a species contributes to their conservation. Multiple paternity is a reproductive behavior increasing effective population size, which could increase genetic diversity particularly in populations submitted to bottlenecks events. In Argentina, wild populations of Caiman latirostris are subject of a management plan devoted to their preservation and sustainable utilization based on its commercial interest. This program started in response to the evident numeric reduction of the populations, as a consequence of hunting pressure and habitat modification; it had a remarkable success in population recovery allowing the commercial use of C. latirostris. Data on reproductive behavior of C. latirostris are limited because mating occurs in the water and the information about their genetic diversity is scarce too. Our specific aims were to study the mating system and population genetic structure applying microsatellite markers in twelve C. latirostris families. The obtained results showed highly significant difference among populations and a lack of correspondence between geographical distance and genetic differentiation suggesting that populations of C. latirostris represent unstable metapopulations. In the paternity analysis was detected more than one father in two nests, which could be explained by capacity of storage sperm, proposed in females of a related species. The behavior of multipaternity could contribute to maintain viable populations of &nbsp;C. latirostris, since the maintenance of genetic variability within populations could help increase their capacity to respond to selective pressure. Further studies employing genetic and behavioral framework are needed to better understand the reproductive biology of C. latirostris.","palabras_clave":"CAIMAN LATIROSTRIS|MOLECULAR MARKERS|MULTIPLE PATERNITY|POPULATION GENETICS|SUSTAINABLE USE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89355,"idioma_id":5,"titulo":"Trabajadores de la industria terminal automotriz del Mercosur: acciones ante la nueva etapa de la crisis de superproducción mundial del capital.","resumen":"En la segunda mitad del 2008 se puso en evidencia el avance manifiesto de una nueva etapa de crisis de superproducción a nivel mundial. Crisis que tiene como una de sus expresiones más notorias la crisis en la industria automotriz.En los países que conforman el Mercosur, esta crisis vino a cerrar un ciclo de crecimiento \u201Crecord\u201D de la industria, que se hubo iniciado con la recuperación del proceso nacional argentino desde la post-convertibilidad coincidente con la recuperación del crecimiento sostenido del proceso nacional de Brasil. El fin de éste ciclo de crecimiento \u201Crecord\u201D implicó un proceso de reacomodamiento de la producción que tuvo como principal acción por parte de las empresas la reducción abrupta de la producción y la consiguiente reducción de stocks.Frente al cambio de escenario los trabajadores del sector se encontraron inmersos en un proceso que incluyó desde adelantamiento de vacaciones hasta las suspensiones, retiros voluntarios, no renovación de contratos y despidos.El presente trabajo se propone analizar las características mostradas por las distintas respuestas protagonizadas por los trabajadores de la industria automotriz en ambos países, frente a este nuevo escenario de crisis.A través de la información recogida desde las cámaras que nuclean a las empresas terminales, la vertida por las organizaciones sindicales de los trabajadores (Confederación Nacional de Metalúrgicos-CUT Y SMATA-CGT) y la divulgada por la prensa, se sistematizan y analizan distintas acciones adoptadas por los trabajadores, por las empresas, así como las intervenciones de los estados nacionales frente a la crisis.En el tratamiento de la información relevada se resaltan las limitaciones en la acción de los trabajadores, al no haber logrado avanzar sobre las condiciones de contratación y uso de la fuerza de trabajo implementadas por la reforma laboral aplicada durante la década del 90. Límite que en este nuevo escenario se pone plenamente de manifiesto, ya que si bien la negociación colectiva se vio reactivada -y en un proceso creciente- en el período anterior a la crisis, la mayor parte de las negociaciones giraron en torno a la cuestión salarial. Es decir que no se modificaron (y sí se ratificaron) las condiciones flexibles de contratación (contratos a plazo determinado, contratos para tareas eventuales \u2013sólo en la Argentina-) y de uso de la fuerza de trabajo (banco de horas, condiciones de suspensión de actividades, polivalencia, etc.). De forma tal que en cuanto la producción automotriz dejó de crecer las empresas pudieron hacer uso de estos mecanismos para resguardarse de la crisis.","palabras_clave":"CRISIS MUNDIAL|RELACIONES LABORALES|FLEXIBILIZACION LABORAL|RESISTENCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89356,"idioma_id":4,"titulo":"Sequence characterization, in silico mapping and cytosine methylation analysis of markers linked to apospory in Paspalum notatum","resumen":"In previous studies we reported the identification of several AFLP, RAPD and RFLP molecular markers linked to apospory in Paspalum notatum. The objective of this work was to sequence these markers, obtain their flanking regions by chromosome walking, and perform an in silico mapping analysis in rice and maize. Moreover, methylation-sensitive RFLP experiments were carried out to investigate the methylation status of two apospory-related sequences. Fourteen molecular markers were analyzed. Several protein-coding sequences were identified. Copy number estimations and RFLP linkage analysis showed that sequence PnMAI3 displayed 2-4 copies per genome and linkage to apospory. Extension of this marker by chromosome walking revealed an additional protein-coding sequence mapping in silico at the apospory-syntenic regions of rice and maize. Through the global sequencing procedure, ~ 5 kb corresponding to different markers were characterized. Sequence information allowed a more refined synteny analysis with model species. Results indicate synteny with segments of chromosomes 2 and 12 of rice, as well as 3 and 5 of maize. Two apomixis-associated loci were tested in methylation-sensitive RFLP experiments on genomic DNA extracted from leaves. Although both target sequences were methylated, no methylation polymorphisms associated with the mode of reproduction were detected.","palabras_clave":"Paspalum notatum|apomixis|apospory|molecular markers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89357,"idioma_id":4,"titulo":"Surface characterization of self assembled N-Cu nanostructures","resumen":"We report on the process of low energy N2+   implantation and annealing of a Cu(0&nbsp;0&nbsp;1) surface. Through AES we study   the N diffusion process as a function of the substrate temperature. With   STM and LEIS we characterize the surface morphology and the electronic   structure is analyzed with ARUPS. Under annealing (500&nbsp;&lt;&nbsp;T&nbsp;&lt;&nbsp;700&nbsp;K) N migrates to the surface and reacts forming a CuxN compound that decomposes at temperatures above 700&nbsp;K. LEIS measurements show that N locates on the four-fold hollow sites of the Cu(0&nbsp;0&nbsp;1) surface in a c(2&nbsp;×&nbsp;2)   arrangement. Finally, a gap along the [0&nbsp;0&nbsp;1] azimuthal direction is   determined by ARUPS. DFT calculations provide support to our   conclusions.","palabras_clave":"COPPER NITRIDE|NANOSTRUCTURES|SELF-ASSEMBLING|LEIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89358,"idioma_id":4,"titulo":"Intensive field surveys in conservation planning: Priorities for cactus diversity in the Saltenian  Calchaquíes Valleys (Argentina","resumen":"Cacti are a plant group of special conservation interest because of their economic value and the threats they face. In this paper, we studied cactus diversity in the Saltenian Calchaquíes Valleys, the most diverse region in Argentina. Our goals were: 1) to analyze diversity patterns, 2) to evaluate the effectiveness of the extant reserve network, 3) to select the complementary areas for cactus conservation, and 4) to evaluate the effectiveness of endemic cactus diversity as surrogate for all cactus diversity in this region. In our study, we recorded 41 cactus species, 22 of which were endemic. The most diverse cells of the survey grid were located in the High Monte ecoregion and in transition zones between this ecoregion and the Dry Chaco and Central Andean Puna ecoregions. Spatial congruence between species richness and endemism was high. The extant Saltenian Calchaquíes Valleys reserve network was effective for the cactus conservation because only three cells were necessary to maximize their protection with minimum representation. Endemic species had a good performance as surrogates of all cactus diversity. The present study is the first to define cactus diversity and to establish conservation strategies in this singular region.","palabras_clave":"Cactaceae|Endemism|Reserve network|Species richness|Surrogate"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89359,"idioma_id":4,"titulo":"Level anti-crossings in ParaHydrogen Induced Polarization experiments with Cs-symmetric molecules","resumen":"Hyperpolarization by means of ParaHydrogen Induced Polarization (PHIP) has found increasing applications since its discovery. However, in the last decade only a few experiments have been reported describing the hydrogenation of symmetric molecules. A general AA'BB' system is studied here. Calculations of the spin dynamics with the density matrix formalism support the experimental &#64257;ndings, providing profound understanding of the experiments in Cs-symmetric molecules. Level anti-crossings between states related to the triplet and the singlet state of one pair of the protons are identi&#64257;ed as being responsible for hyperpolarization transfer in a PHIP experiment, when the former p-H2 protons occupy the sites AA' .The hydrogenation of acetylene dicarboxylic acid dimethylester with parahydrogen is used to illustrate the case. The theoretical treatment applied to this particular reaction explains the signal enhancements in both groups of protons in the spectrum when the sample is placed in the proper magnetic &#64257;eld strength, including the phase inversion of the signal of the methyl group.The treatment described here can be extended to every molecule which can be approximated as an AA' BB' system.","palabras_clave":"Parahydrogen|Hyperpolarization|Enhanced NMR|Symmetric Molecules|Hyperpolarization Trenasfer|PHIP|Level Anti-crossings"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89360,"idioma_id":4,"titulo":"Long-Lived 1H Singlet Spin States Originating from Para-Hydrogen in Cs-Symmetric Molecules Stored for Minutes in High Magnetic Fields","resumen":"Nuclear magnetic resonance (NMR) is a very powerful tool in physics,   chemistry, and life sciences, although limited by low sensitivity. This   problem can be overcome by hyperpolarization techniques dramatically   enhancing the NMR signal. However, this approach is restricted to   relatively short time scales depending on the nuclear spin-lattice   relaxation time T1 in the range of seconds. This makes   long-lived singlet states very useful as a way to extend the   hyperpolarization lifetimes. Para-hydrogen induced polarization (PHIP)   is particularly suitable, because para-H2 possesses singlet   symmetry. Most PHIP experiments, however, are performed on asymmetric   molecules, and the initial singlet state is directly converted to a NMR   observable triplet state decaying with T1, in the order of   seconds. We demonstrate that in symmetric molecules, a long-lived   singlet state created by PHIP can be stored for several minutes on   protons in high magnetic fields. Subsequently, it is converted into   observable high nonthermal magnetization by controlled singlet-triplet   conversion via level anticrossing.","palabras_clave":"ParaHydrogen|Hyperpolarization|Nuclear Magnetic Resonance|Long lived states"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89361,"idioma_id":4,"titulo":"Evolutionary Multi-Objective Scheduling Procedures in Non-Standardized Production Processes","resumen":"Scheduling problems can be seen as multi-objective optimization problems (MOPs), involving the simultaneous satisfaction of several goals related to the optimal design, coordination, and management of tasks. The complexity of the goal functions and of the combinatorial methods used to find analytical solutions to them is quite high. The search for solutions (Pareto-optima) is better served by the use of genetic algorithms (GAs). In this paper, we analyze the performance of the non-dominated sorting genetic algorithm II (NSGAII), strength Pareto evolutionary algorithm II (SPEAII), and their predecessors, NSGA and SPEA, when these are devoted to scheduling tasks in non-standardized production activities.","palabras_clave":"Job-shop scheduling|Local search|Memetic algorithm|Multi-objective optimization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89362,"idioma_id":5,"titulo":"Mortalidad y años de esperanza de vida perdidos a causa del consumo de alcohol en Argentina. 2008","resumen":"Los datos sobre prevalencia de consumo dealcohol en Argentina, podrían indicar un fuerte impacto delconsumo de alcohol en la mortalidad general y en la esperanza de vida,en especial en el sexo masculino. El objetivo de este trabajo esanalizar el impacto del consumo de alcohol en la mortalidad de losargentinos en el año 2008, mediante la metodologíapropuesta por el Centers of Disease Control and Prevention (CDC, 1990),suavizando los casos con el promedio de defunciones producidas entrelos años 2007 a 2009. Así mismo se analizan losAños de Esperanza de Vida Perdidos (AEVP) del año 2008,según la metodología propuesta por Arriaga (1996). Seutilizaron fuentes de datos secundarios: registro de defunciones ydatos de prevalencia de consumo de alcohol en la población. Enese año se produjeron 11.013 muertes atribuidas al consumo dealcohol (3,6% del total de muertes en la población), de lascuales el 73% se produjeron en el sexo masculino. Los AEVP a causa delconsumo de alcohol fueron de 0,20 años en mujeres y 0,80años en hombres. Las causas con más impacto en lapérdida de esperanza de vida son las causas externas demortalidad y el grupo más afectado fue el de 15 a 34años. Los resultados de este trabajo reflejan la necesidad depotenciar las estrategias de intervención dirigidas a controlarel consumo de alcohol, en especial en hombres jóvenes.                                                 ","palabras_clave":"Mortalidad|Alcoholismo|Esperanza de Vida"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89363,"idioma_id":4,"titulo":"Effectiveness of normalized difference water index in modelling Aedes aegypti house index","resumen":"The application of remotely sensed data to public health has increased in Argentina in the past few years, especially to study","palabras_clave":"WATER|INDEX|MODELLING|DENGUE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89364,"idioma_id":4,"titulo":"New records of mosquito species (Diptera: Culicidae)  for the provinces of Chaco and Formosa,  Argentina.","resumen":"ABSTRACT. Seven mosquito species are recorded for the first time for the northeastern Argentina: Culex (Melanoconion) albinensis, Cx. (Mel.) elevator, Cx. (Mel.) intrincatus, and Cx.(Mel.) serratimarge for Formosa Province, and Sabethes (Peytonulus) undosus, Sa. (Sabethinus) melanoninphe, and Toxorhynchites (Lynchiella) theobaldi for Chaco Province. The geographical distribution of these species is extended to the northeastern Argentina, as well as, the number ofspecies increases to 97 and 75 for the provinces of Chaco and Formosa, respectively.","palabras_clave":"MOSQUITOS|DISTRIBUCION|CHACO|FORMOSA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89365,"idioma_id":5,"titulo":"Una Nueva especie de Brachyglossula Hedicke con una morfología particular del primer tergo metasómico (Hymenoptera, Colletidae)","resumen":"Se describe una nueva especie, Brachyglossula schlumpbergeri, en base a dos machos colectados en eldepartamento de Cochabamba, Bolivia. Esta nueva especie tiene una estructura notable en el primer tergo metasómico,se trata de una proyección basal en forma de quilla que no está presente en ninguna otra abeja conocida.También se destaca por no poseer la mandíbula tridentada característica de los machos del género. Se amplíatambién el rango de distribución norte de B. martinezi y B. communis en Bolivia y se aportan registros floralesasociados a los ejemplares de las especies tratadas.","palabras_clave":"abejas|Sudamérica|Colletidae|nueva especie"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89366,"idioma_id":4,"titulo":"An Anionic synthetic sugars containing 6-SO3-NAcGlc mimic the sulfated cruzipain epitope that plays a central role in immune recognition","resumen":"Cruzipain (Cz), the major cysteine proteinase of Trypanosoma cruzi, is a  glycoprotein that contains sulfated high-mannose-type oligosaccharides.  We have previously determined that these sulfate groups are targets of specific  immune responses. In order to evaluate the structural requirements for  antibody recognition of Cz, a systematic structure\u2013activity study of the  chemical characteristics needed for antibody binding to the Cz sulfated epitope  was performed by immunoassays. With this aim, different synthesized  molecules were coupled to the proteins BSA and aprotinin and confronted  with (a) mouse sera specific for Cz and its carboxy-terminal (C-T) domain,  (b) antibodies raised in rabbits immunized with Cz and its C-terminal  domain and (c) IgGs purified from human Chagas disease sera. Our results  indicate that a glucosamine containing an esterifying sulfate group in position  O-6 and an N-acetyl group was the preferred epitope for the immune  recognition of sera specific for Cz and its C-T domain. Although to a  minor extent, other anionic compounds bearing sulfate groups in different  positions and number as well as different anionic charged groups including  carboxylated or phosphorylated monosaccharides, disaccharides and oligosaccharides  were recognized. In conclusion, we found that synthetic anionic  sugar conjugates containing N-acetyl D-glucosamine-6-sulfate sodium salt  (GlcNAc6S) competitively inhibit the binding of affinity purified rabbit  anti-C-T IgG to the C-T extension of Cz. Extending these findings to the  context of natural infection, immune assays performed with Chagas disease  serum confirmed that the structure of synthetic GlcNAc6S mimics the  N-glycan-linked sulfated epitope displayed in the C-T domain of Cz.","palabras_clave":"cruzipain|glycoprotein|sulfated GlcNAc|Trypanosoma cruzi"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89367,"idioma_id":5,"titulo":"Vetas mesotermales de Pb-Zn-Ag-Au emplazadas al este del Batolito Cerro Áspero, Sierra de Comechingones, Córdoba","resumen":"En  este trabajo se presenta un modelo descriptivo de vetas mesotermales portadoras  de Pb-Zn- Ag-Au hospedadas en milonitas de la Faja de Cizalla Guacha Corral  (FCGC) a ~2 km al este del Batolito Cerro Áspero (BCA) en la Sierra de  Comechingones, Córdoba. Las mineralizaciones conforman cuerpos tabulares de alto  buzamiento, con un control estructural marcado y un desarrollo longitudinal  discontinuo en dirección NO-SE que alcanza los 8 km. Las vetas mayores poseen  potencias entre 0,2 y 1 m y se asocian con vetillas menores que definen  diversos juegos secundarios. Están compuestas principalmente de cuarzo que es  portador de una variedad de sulfuros, óxidos y carbonatos, tanto de origen  hipogénico como supergénico. Los mayores tenores de metales preciosos se  registraron en las zonas de oxidación de los depósitos, con valores entre  1,63-3,57 g\/t de Au y 149? 216 g\/t de Ag. La alteración hidrotermal de las  rocas de caja es común y en sectores muy desarrollada. Consiste principalmente  de sericitización penetrativa y hematización de moderada a fuerte intensidad  que se desarrolla en venillas tensionales. Subordinadamente ocurren  silicificación y carbonatación. Las relaciones de campo, evidencias estructurales,  microestructurales y petrográficas sugieren que el emplazamiento de estos  depósitos ha ocurrido posteriormente a la última fase de deformación de la  FCGC, bajo un regimen de cizalla simple. La vinculación de las mineralizaciones  con el BCA no ha podido establecerse aún en este modelo descriptivo. Los  estudios a futuro están principalmente orientados a determinar la influencia  del magmatismo devónico como un posible metalotecto de las mineralizaciones.","palabras_clave":"Vetas mesotermales|Control estructural|Metales preciosos|Faja de Cizalla Guacha Corral|Sierra de Comechingones"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89368,"idioma_id":4,"titulo":"WHEAT FLOUR ENRICHED WITH CALCIUM AND INULIN: A STUDY OF HYDRATION AND RHEOLOGICAL PROPERTIES OF DOUGH","resumen":"The aim of this work was to study the effect of calcium (Ca) carbonate-inulin (In) systems on hydration and rheological properties of wheat flour dough. Wheat flour, Ca carbonate from 108 to 252 (mg Ca\/100 g flour) content, and enriched In oligofructose at levels of 1% to 13% (flour basis), were used. Hydration dough properties were researched  17 analyzing water absorption (Wabs), moisture content (Mcont), water activity (aw), and relaxation time (&#955;). Wabs and aw decreased with increasing In levels independently of Ca content. Dough development time increased with the amount of Ca. In the presence of In, samples with the lowest content of Ca were those showing the highest development time  values. Inulin was the main component that controled Wabs in dough. In the presence of CaCO3, although water seemed to be in a free state according to the high aw value measured (>0.975), the low value of relaxation time obtained suggests less molecular mobility. Rheological properties of dough were studied by texture, relaxation, and viscoelasticity assays. Dough hardness and consistency significantly   increased with Ca and mainly with In content. At high In content, dough texture was enhanced by CaCO3 due to the fact that this salt could behave as dough strengthener. Adhesiveness of dough was not modified by CaCO3 at low In levels. However, Ca affected adhesiveness at intermediate In levels. Adhesiveness was significantly increased by In presence. Calcium and In both diminished dough cohesiveness. The In presence increased dough elasticity, independently of Ca content. A second-order polynomial model and response surface methodology were used for studying hydration dependence and rheological parameters (R2>0.771) on Ca and In. Dough Mcont varied with In2 and mainly inversely proportional to In. An inverse dependence of &#955; on In was detected. Dynamic and relaxation elastic moduli (G&#8242; and E3) showed a linear dependence on In.","palabras_clave":"Calcium inulin system |Wheat flour dough | Dough hydration|Dough rheology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89369,"idioma_id":4,"titulo":"Direct reductive amination of aldehydes using lithium-arene(cat.) as reducing system. A simple one-pot procedure for the synthesis of secondary amines","resumen":"A simple one-pot procedure for the direct reductive amination of aldehydes using lithium powder and a catalytic amount of 4,4-di-tert-butylbiphenyl (DTBB) or a polymer supported naphthalene as reducing system is described. The direct reductive amination of a variety of aldehydes with primary amines was achieved simply by adding a mixture of the corresponding carbonyl compound and the amine, over a solution of the lithium arenide in THF at room temperature. For most of the substrates tested the main reaction products were the secondary amines along with variable amounts of the corresponding alcohol and\/or imine products. Theoretical DFT calculations have been applied in order to explain the differences in reactivity observed for aromatic substrates.","palabras_clave":"LITHIUM-ARENE|ALDEHYDES|REDUCTIVE AMINATION|SECONDARY AMINES|DFT METHODS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89370,"idioma_id":4,"titulo":"Differences in yield, biomass and their components between triticale and wheat grown under contrasting water and nitrogen environments","resumen":"A number of evidences have shown that triticale produces more above-ground dry matter (AGDM) than  other winter cereals in dry environments. As AGDM accumulated by crop before anthesis has been pointed  out as an important attribute under rainfed environments, the comparison of its physiological attributes  (i.e. accumulated intercepted radiation \u2013 IPAR and radiation use efficiency \u2013 RUE), comparing among  different cultivars and respect to other cereals, could be valuable to identify prospective traits to be  used in breeding programs. Three experiments were carried out during the 2004 and 2005 growing  seasons to (i) determine the effect of water stress on the yield and the eco-physiological components  of biomass (i.e. accumulated intercepted radiation and RUE throughout the crop cycle) in a wide range  of triticale cultivars to evaluate the genotypic variability (in interaction with water regime) for those  traits and (ii) to analyze the causes for the commonly found differences in yield and AGDM between  triticale and wheat under different water and nitrogen conditions. The triticale cultivars showed an  important variability in yield and yield components sensitivity to drought. Water restrictions reduced  AGDM, more than its partitioning to the reproductive organs, due to reductions in crop growth rate mainly  through reduced RUE when different triticale cultivars were analyzed. Triticale outyielded wheat due to  an increased biomass at anthesis and at maturity associated with higher RUE, probably due to a better  light distribution into the canopy, more than by differences in IPAR. Triticale advantages were especially  noticeable in the Mediterranean-type environment where yield and biomass were almost twice than that  of wheat, associated with differences of similar magnitude in RUE","palabras_clave":"Triticale|Biomass"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89371,"idioma_id":4,"titulo":"DIFFERENCES BETWEEN WHEAT AND BARLEY IN LEAF AND TILLERING CO-ORDINATION UNDER CONTRASTING NITROGEN AND SULFUR CONDITIONS","resumen":"It is traditionally assumed that barley has a higher tillering capacity than wheat whatever the environmentalcondition; however, this supposition has not been formally tested under experimental conditionsnor analyzed its relationship with leaf appearance. In the present work, leaf appearance and tilleringdynamics were studied in wheat and barley genotypes grown under contrasting nitrogen and sulfur levelsat sowing. There was no difference in phenology (seedling emergence, first visible node and flowering)between wheat and barley or due to different nutrients. Phyllochron in barley tended to be higher than(or at least equal to) that observed in wheat, without effect of the N or S levels on this trait. Differences infinal leaf number were negligible. Tillering dynamics was analyzed considering the tillering appearancerate (TAR), the maximum number of tillers appeared (MTN), the tillering mortality rate (TMR), and thefinal number of tillers per plant (FTN). TAR was significantly greater in barley than in wheat genotypesin all experiments. In both species, TAR was enhanced as N supply was increased while S promoted TARonly under high N conditions. The MTN was positively and significantly associated with TAR. Althoughcessation of tillering was similar between both species, the maximum number of tillers was superior inbarley than in wheat, due to the differences between species in tiller appearance rate. A high MTN wasrelated to a high tiller mortality rate. In spite of that counterbalance, FTN was closely related to MTN; as aconsequence, FTN was pre-defined during the early phase of the tillering process. Barley showed highervalues of tiller initiated per leaf appeared (synchrony) than wheat, while N and S deficiencies decreasedthat synchrony.","palabras_clave":"Tillering|Wheat|Barley"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89372,"idioma_id":4,"titulo":"Low levels of residual oil fly ash (ROFA) impair innate immune response against environmental mycobacteria infection in vitro","resumen":"Epidemiological studies have shown that pollution derived from industrial and vehicular transportation provokes adverse health effects causing broad spectrum of ambient respiratory diseases. Therefore, air pollution should be taken into account when microbial diseases are evaluated. Environmental mycobacteria(EM) are opportunist pathogens in a variety of immunocompromised patients eliciting significant impact on human morbidity and mortality. The aim of this study was to evaluate the in vitro effects of residual oil fly ash (ROFA) on the alveolar macrophages (AMs) response to opportunistic bacteria. AMs from young Wistar rats were obtained by bronchoalveolar lavage and co-cultured with Mycobacterium phlei (MOI 10). We exposed AM cultures to ROFA to characterize the effect of low ROFA concentrations(0, 2.5, and 5 lg\/ml) and evaluated the response of pre-exposed AM against the bacilli. Low ROFA concentrations induced superoxide anion and nitrites production (p < 0.001). Pre-exposure to ROFA (2.5 and 5 lg\/ml) caused a significant reduction on TNFa (p < 0.001) and superoxide anion (p < 0.001) production but, did not modify the nitrite production when AM were co-cultured with M. phlei. In addition, ROFA significantly diminished AM killing ability in culture (p < 0.001). Hence, our results indicate that preexposure to low levels of ROFA modifies the innate pulmonary defence mechanisms against environmental mycobacteria.","palabras_clave":"Alveolar macrophages  |Environmental mycobacteria|Mycobacterium phlei| ROFA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89373,"idioma_id":4,"titulo":"Angiotensin-(1-7) Attenuates Diabetic Nephropathy in Zucker Diabetic Fatty Rats","resumen":"Abstract  Angiotensin (ANG)-(1-7) is known to attenuate diabetic nephropathy; however, its role in the modulation of renal inflammation and oxidative stress in type 2 diabetes is poorly understood. Thus in the present study we evaluated the renal effects of a chronic ANG-(1-7) treatment in Zucker diabetic fatty rats (ZDF), an animal model of type 2 diabetes and nephropathy. Sixteen-week-old male ZDF and their respective controls [lean Zucker rats (LZR)] were used for this study. The protocol involved three groups: 1) LZR + saline, 2) ZDF + saline, and 3) ZDF + ANG-(1-7). For 2 wk, animals were implanted with subcutaneous osmotic pumps that delivered either saline or ANG-(1-7) (100 ng·kg(-1)·min(-1)) (n = 4). Renal fibrosis and tissue parameters of oxidative stress were determined. Also, renal levels of interleukin-6 (IL-6), tumor necrosis factor-&#945; (TNF-&#945;), ED-1, hypoxia-inducible factor-1&#945; (HIF-1&#945;), and neutrophil gelatinase-associated lipocalin (NGAL) were determined by immunohistochemistry and immunoblotting. ANG-(1-7) induced a reduction in triglyceridemia, proteinuria, and systolic blood pressure (SBP) together with a restoration of creatinine clearance in ZDF. Additionally, ANG-(1-7) reduced renal fibrosis, decreased thiobarbituric acid-reactive substances, and restored the activity of both renal superoxide dismutase and catalase in ZDF. This attenuation of renal oxidative stress proceeded with decreased renal immunostaining of IL-6, TNF-&#945;, ED-1, HIF-1&#945;, and NGAL to values similar to those displayed by LZR. Angiotensin-converting enzyme type 2 (ACE2) and ANG II levels remained unchanged after treatment with ANG-(1-7). Chronic ANG-(1-7) treatment exerts a renoprotective effect in ZDF associated with a reduction of SBP, oxidative stress, and inflammatory markers. Thus ANG-(1-7) emerges as a novel target for treatment of diabetic nephropathy.","palabras_clave":"kidney|neutrophil gelatinase-associated lipocalin|renin-angiotensin system|oxidative stress"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89374,"idioma_id":4,"titulo":"Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication in alfa-synuclein aggregation","resumen":"Lewy bodies and Lewy neurites, neuropathological hallmarks of several neurological diseases, are mainly made of filamentous assemblies of &#61537;-synuclein. However, other macromolecules including tau, ubiquitin, glyceraldehyde-3-phosphate dehydrogenase and glycosaminoglycans are routinely found associated with these amyloid deposits. Glyceraldehyde-3-phosphate dehydrogenase is a glycolytic enzyme that can form fibrillar aggregates in the presence of acidic membranes but its role in Parkinson\u2019s disease is still unknown. In this work, the ability of heparin to trigger the amyloid aggregation of this protein at physiological conditions of pH and temperature is demonstrated by infrared and fluorescence spectroscopy, dynamic light scattering, small angle X-Ray scattering, circular dichroism and fluorescence microscopy. Aggregation proceeds through the formation of short rod-like oligomers, which elongates in one-dimension. Heparan sulphate was also capable of inducing glyceraldehyde-3-phosphate dehydrogenase aggregation, but chondroitin sulphates A, B and C together with dextran sulphate had negligible effect. Aided with molecular docking simulations a putative binding site on the protein is proposed providing a rational explanation for the structural specificity of heparin and heparan sulphate. Finally, it is demonstrated that in vitro the early oligomers present in the glyceraldehyde-3-phosphate dehydrogenase fibrillation pathway promote &#61537;-synuclein aggregation. Taking into account the toxicity of &#61537;-synuclein prefibrillar species, the heparin-induced glyceraldehyde-3-phosphate dehydrogenase early oligomers might come in useful as a novel therapeutic strategy in Parkinson\u2019s disease and other synucleinophaties.","palabras_clave":"Parkinson|GAPDH|amyloid|heparin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89375,"idioma_id":4,"titulo":"Exchange-bias effect at La0.75Sr0.25MnO3\/LaNiO3 interfaces","resumen":"We show that ferromagnetic\/paramagnetic La0.75Sr0.25MnO3\/LaNiO3 multilayers present an unexpectedmagnetic exchange-bias effect (EBE), observed in field-cooled magnetization loops. The exchange-bias fieldand the enhancement of the coercivity vanish around 50 K. We demonstrate that the oxidation state of the Niand Mn cations changes from Mn3+-Ni3+ to Mn4+-Ni2+ in the layers close to the interface probed by x-rayabsorption spectroscopy measurements. The variation of the valence states is accompanied by a change in themagnetic behavior of the cations at the La0.75Sr0.25MnO3\/LaNiO3 interface, possibly giving rise to the formationof magnetic or magnetically frustrated regions that may pin the ferromagnetic La0.75Sr0.25MnO3 layers and explainthe EBE.","palabras_clave":"EXCHANGE BIAS EFFECT|LSMO\/LNO INTERFACES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89376,"idioma_id":4,"titulo":"Magnetic properties of nanoscale crystalline maghemite obtained by a new synthetic route","resumen":"In this work we describe the synthesis and characterization of maghemite nanoparticles obtained by a new synthetic route. The material was synthesized using triethylamine as a coprecipitation agent in the presence of the organic ligand N,N0-bis(3,5-di-tert-butyl-catechol)-2,4-diaminotoluene (LCH3). Mössbauer spectrum at 4 K shows typical hyperfine parameters of maghemite and Transmission Electron Microscopy images reveal that the nanoparticles have a mean diameter of 3.9 nm and a narrow size distribution. AC magnetic susceptibility in zero field presents an Arrhenius behavior with unreasonable relaxation parameters due to the strong influence of dipolar interaction. In contrast when the measurements are performed in a 1kOe field, the effect of dipolar interactions becomes negligible and the obtained parameters are in good agreement with the static magnetic properties. The dynamic energy barrier obtained from the AC susceptibility results is larger than the expected from the average size observed by HRTEM results, evidencing the strong influence of the surface contribution to the anisotropy.","palabras_clave":"NANOMAGNETISM|MAGNETIC MATERIAL|CO-PRECIPITATION|DIPOLAR INTERACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89377,"idioma_id":4,"titulo":"Thermal stability and the magnetic properties of hybrid vanadium oxide-tetradecylamine nanotubes","resumen":"Vanadium oxide nanotubes (NTs) were synthesized by the sol-gel method followed by a long-term hydrothermal treatment. The obtained nanotubes have a multiwall structure, and 70% of vanadium ions are in the V 4+ state. This percentage was derived by evaluating three components of the magnetic susceptibility; namely, (i) the paramagnetic Curie-Weiss behavior, (ii) antiferromagnetic dimers, and (iii) magnetic trimers. The as-made NTs were annealed in situ in the cavity of the electron paramagnetic resonance (EPR) spectrometer. The line shape changes irreversibly at 390 K, and the EPR susceptibility presents an anomaly at 425 K. These changes are interpreted as a partial oxidation of the V 4+ ions and consequently a decrease in the concentration of the magnetic species. The quantification of the V 4+ ions of the annealed NTs reveals a diminution to 39% of V 4+, a weakening of the Curie-Weiss and antiferromagnetic dimers contributions, and the suppression of magnetic trimers. Vibrational studies confirm the decrease of V 4+ amount. © 2012 American Institute of Physics.","palabras_clave":"Vanadium oxide nanotubes|Magnetic susceptibility|Magnetic resonance|Dimers"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89378,"idioma_id":4,"titulo":"'Mycoflora and natural incidence of selected mycotoxins in rabbit and chinchilla feeds'","resumen":"Mycotoxins are secondary metabolites produced by filamentous fungi that cause a toxic response when ingested by animals or man. Demand of natural fur, such as those from rabbit and chinchilla, produced under controlled conditions, has increased worldwide. The toxicogenic mycoflora contaminating feeds for these animals was enumerated and identified. Six of the major mycotoxins implicated in animal mycotoxicosis were detected and quantified. Moulds count ranged from &lt; 10 to 4 . 7 × 1 0 5 CFU g&#8722;1; 14% of the samples exceeded the limit that determines hygienic feed quality. More than twenty species belonging to the five most important mycotoxigenic mould genera were recovered. Among the analyzed mycotoxins, aflatoxins were recovered in 100% of the examined samples, deoxynivalenol in 95%, fumonisins in 100%, ochratoxin A in 98%, T2 toxin in 98%, and zearalenone in 100%. Cooccurrence of mycotoxins was observed in 100% of the samples analyzed. Exposure to multiple mycotoxins was thus demonstrated for these animals.","palabras_clave":"Mycotoxins|Fungi|Feeds|Rabbit"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89379,"idioma_id":5,"titulo":"El Marco Categorial de la Crisis Ambiental en un Contexto Globalizado","resumen":"El trabajo desarrollado se estructura en torno a la construcción de un marco categorial a partir del cual se propone una síntesis de la posición adoptada por el pensamiento ambiental crítico, en cuanto al análisis de las características específicas que adopta la crisis ambiental en el marco del proceso globalizador.  A partir de este análisis se propone inferir la relación causal entre las características de la modernidad avanzada y la profundización de la crisis ambiental, teniendo en cuenta las contradicciones que se vislumbran entre sus manifestaciones crecientes y las dificultades que conlleva la implementación de estrategias alternativas de solución, considerando la capacidad del sistema de integrar sus elementos distorsivos a través de dispositivos o mecanismos de reproducción, desde los cuales, las relaciones de poder subyacentes al proceso de ruptura ambiental se mantienen inalterables.","palabras_clave":"análisis categorial|pensamiento ambiental crítico|CRISIS MODERNIDA|RUPTURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89380,"idioma_id":4,"titulo":"Modeling the evolution of item rating networks using time-domain preferential attachment","resumen":"The understanding of the structure and dynamics of the intricate network of connections among people that consumes products through Internet appears as an extremely useful asset in order to study emergent properties related to social behavior.This knowledge could be useful, for example, to improve the performance of personal recommendation algorithms. In this contribution we analyzed five-years records of movie-rating transactions provided by Netflix, a movie rental platform where users rate movies from an on-line catalog. This dataset can be studied as a bipartite user-item network whose structure evolves in time. Even though several topological properties from subsets of this bipartite network have been reported with a model that combinesrandom and preferential attachment mechanisms, there are still many aspects worth to be explored, as they are connected to relevant&nbsp; phenomena underlying the evolution of the network. In this work, we test the hypothesis that bursty human behavior is essential in order to describe how a bipartite user-item network evolves in time. To that end, we propose a novel model that combines, for user nodes, a network growing prescription based on a preferential attachment mechanism acting not only in the {em topological domain} (i.e. based on node degrees) but also in {em time domain}. In the case of items, the model mixes degree preferential attachment and random selection. With these ingredients the model is not only able to reproduce the asymptotic degree distribution, but also showing an excellent agreement with the Netflix data in severaltime-dependent topological properties.","palabras_clave":"Complex Systems|Complex Networks|Recommendation systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89381,"idioma_id":4,"titulo":"On pseudo-applicatives","resumen":"Applicativization is an operation that allows a peripheral (oblique) participant to become a core argument of a predicate. In the tradition of formal linguistics, applicative constructions are considered to be those where the applied argument has all the properties of a direct object, and can thus be passivized and trigger agreement on the verb (Aissen 1983, Marantz 1984, Baker 1988, a.o.). The present article deals with applicatives in two languages of lowland South America. Contrary to what happens in the canonical cases, these applicatives apparently don't change verbal valency, and their main effect seems to be restricted to vary the ordering of syntactic dependents of the predicate. We contend that such applicatives may not be treated as syntactically incorporated adpositions, as is proposed by Baker (1988). Instead, we think that what is called applicative in these languages is a regular adposition, and the observed alternations are simply phonologically or morphologically-driven phenomena. We call such alternations pseudo-applicatives. Keywords: Chorote (Mataco-Mataguayo), Panará (Jê), Mebengokre (Jê), applicatives, word order, incorporation, adpositions ","palabras_clave":"CHOROTE (MATACO-MATAGUAYO)|PANARA (JÊ)|MEBENGOKRÊ (JÊ)|APPLICATIVES|WORD ORDER|INCORPORATION|ADPOSITIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89382,"idioma_id":4,"titulo":"Differential effects of climate, environment, and land use on two sympatric species of Akodon","resumen":"We describe changes in abundance of two rodent species over a 12-year period and assess the relationship between population abundance, climate, and agricultural practices in southern Córdoba Province, Argentina. We estimated abundance from trapping edges of agricultural areas, railway rights of way, and roadsides. Variables considered were: normalized difference vegetation index (NDVI), surface temperature, minimum and maximum temperature, rainfall, and cultivated areas of different crops. Species abundances varied over time; those of Akodon dolores declined, whereas those of A. azarae increased. Climatic and environmental changes may have had differential influences on species abundances. Autumn abundance of A. dolores was positively related to spring rainfall and area of harvested sorghum, and negatively related to NDVI. Akodon azarae abundance was negatively correlated with winter minimum temperature, spring rainfall, and sorghum harvested area, but positively associated with NDVI. On the other hand, both species were negatively correlated with each other. We suggest that environmental conditions may have changed the competition outcome for Akodon spp., and thus, had direct, differential effect on species abundances.","palabras_clave":"agroecosystem|rodent abundance|weather|crops|agricultural practices|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89383,"idioma_id":4,"titulo":"EVIDENCE OF GREGARIOUSNESS IN REBBACHISAURIDS (DINOSAURIA, SAUROPODA, DIPLODOCOIDEA) FROM THE EARLY CRETACEOUS OF NEUQUE´ N (RAYOSO FORMATION), PATAGONIA, ARGENTINA","resumen":"For the first time an association of adult and juvenile rebbachisaurid sauropods is described. The material comes from the Early Cretaceous locality of Agrio del Medio (Neuquén, Argentina). The three specimens apparently formed a single group, and their death seems to have been almost simultaneous. The two juvenile specimens are represented by axial and appendicular bones. These show a close relationship with Zapalasaurus bonapartei, which comes from a different sector of the same basin, but which is approximately the same in age. The discovery at Agrio del Medio suggests that rebbachisaurid sauropods displayed gregarious behaviour. The paleoenvironments in which rebbachisaurids are normally recorded implies a greater tolerance toward extremely arid environments than that shown by macronarian sauropods.","palabras_clave":"Rebbachisauridae|gregariousness |Early Cretaceous|Rayoso Formation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89384,"idioma_id":4,"titulo":"A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A 1 receptors and enhances consolidation of step-down avoidance","resumen":"Adenosine A1 receptor antagonists are of potential value in the treatment of cognitive dysfunction. We have developed compound AJ23 (7-methyl-1-phenyl-1,8-dihydro-pyrazolo-(3,4d)(1,2,4)-triazolo(1,5a)-pyrimidin-4-one) as a novel, non-xanthine based antagonist at A1 receptors. It has micromolar affinity at human A1 receptors with a 45-fold selectivity for A1 over A2A receptors and little affinity for many other receptors and transporters tested in a screening panel. AJ23 blocks A1 receptors in the rat hippocampus, increasing the baseline size of excitatory post-synaptic potentials and blocking the inhibitory effects of adenosine. When administered directly into the rodent hippocampus this compound improves consolidation in a step-down avoidance learning task. The results suggest that AJ23 or derivatives may represent possible leads for further chemical development towards a chemically novel group of antagonists at A1 receptors with potential value as cognitive enhancers.","palabras_clave":"Adenosine|A1 receptors|Non-xanthine antagonists|Purine receptors|Hippocampus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89385,"idioma_id":5,"titulo":"Nuevos modelos de gestión pública y cultura organizacional","resumen":"La crisis internacional plantea la posibilidad de un cambio de paradigma en la cultura organizacional. El rol del Estado, la formulación de políticas públicas y las nuevas tecnologías de la gestión pública son elementos centrales del debate sobre un nuevo modelo organizacional.","palabras_clave":"MODELOS|CULTURA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89386,"idioma_id":4,"titulo":"?\tAminopropyl-modified mesoporous silica SBA-15 as recovery agents of Cu(II)-sulfate solutions: Adsorption efficiency, functional stability and reusability aspects","resumen":"Hybrid mesoporous materials are potentially useful for metal ion scavenging and retrieval because of their high surface areas, controlled accessibility and tailored functionalization. Some aspects that are linked to the performance of HMM include pore accessibility, stability of the organic functions and reusability. Knowledge of these aspects is critical in the design of adsorption?desorption protocols. In this work we produce and characterize propylamino-substituted large pore silica (SBA-15-N), which is submitted to Cu(II) adsorption from copper sulfate solutions, followed by desorption in acid media and material regeneration. We find that the hybrid material is an efficient adsorbent (1.15?1.75 mmol Cu(II) g&#8722;1), although a fraction of the organic groups is lost during the adsorption process. An X-ray photoelectron spectroscopy (XPS) study demonstrates that the contents of amino groups are higher in the material surface, leading to different behaviors in Cu(II) complexation along the material. These materials can be regenerated by exposure to acidic media. Thermal processing of the hybrid materials leads to better durability in aqueous solutions during reprocessing, due to enhanced polycondensation of the inorganic framework. Thermally treated samples, once regenerated, are efficient adsorbents in a second step of Cu(II) adsorption. We discuss the materials processing factors involved in the improved adsorption of Cu(II), its quantitative release and reusability of the material.","palabras_clave":"SOL-GEL|ABSORBENT|MESOPOROUS|HYBRID"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89387,"idioma_id":4,"titulo":"WISH cell line: From the antiviral system to a novel reporter gene assay to test the potency of human IFN-&#945; and IFN-&#946;","resumen":"Interferons (IFNs) are potent biologically active proteins that are widely used as biopharmaceuticals, so their potency must be correctly identified. Usually, the biological activity is quantified by a bioassay based on its capacity to induce an antiviral state in target cells, but this type of assays is subject to virus manipulation-related issues and they show considerable intra- and inter-assay variability.In this work, we generated a reporter gene assay (RGA) supported on the WISH-Mx\/eGFPreporter cell line to determine human type I IFN activity. WISH cells were stably transfectedwith the enhanced green fluorescent protein (eGFP) gene under the control of type I IFNinducible Mx2 promoter.This system implies the use of a standardized cell line for human IFN-potency analysis such asWISH cells and the simultaneous use of the sensitive reporter gene eGFP, having also several advantages when compared to antiviral activity assays and other RGAs: it can determine the potency of hIFN-&#945; and hIFN-&#946; using only one cell line showing the highest expression of eGFP after 28 h and being only observed in cells treated with type I IFNs due to the specificity of the Mx promoter. It is a sensitive assay and it represents a safe alternative when compared with the conventional antiviral tests. The cell line showed the same sensitivity along 57 generations, allowing its use during two months of successive culture. The inter- and intra-assay coefficients of variation were lower than 20%, demonstrating its reproducibility. In addition, this reporter cell line can be used for the conventional antiviral assay, either for hIFN-&#945; or hIFN-&#946;.In conclusion, we have developed an alternative reporter system for the analysis of type I IFNs, in which its performance make it a suitable candidate to replace or complement conventional bioassays that are currently employed to measure IFN potency.","palabras_clave":"eGFP|MX PROMOTER|IFN-&#945;|IFN-&#946;|WISH cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89388,"idioma_id":4,"titulo":"A three-dimensional study of the glottal jet","resumen":"This work builds upon the e_orts to characterize the three-dimensional features of the glottal jet during vocal fold vibration. The study uses a Stereo- scopic Particle Image Velocimetry setup on a self-oscillating physical model of the vocal folds with a uniform vocal tract. Time averages are documented and compared against observations reported for jets exiting elongated nozzles. Phase averages are locked to the audio signal and used to obtain a volumetric reconstruction of the jet. From this reconstruction, the intra-cycle dynamics of the jet axis switching is disclosed ","palabras_clave":"pulsating jet"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89389,"idioma_id":4,"titulo":"Strong and weak constraint variational assimilations for reduced order fluid flow modeling","resumen":"In this work we propose and evaluate two variational data assimilation techniques for the estimation of low order surrogate experimental dynamical models for fluid flows. Both methods are built from optimal control recipes and rely on proper orthogonal decomposition and a Galerkin projection of the Navier Stokes equation. The techniques proposed differ in the control variables they involve. The first one introduces a weak dynamical model defined only up to an additional uncertainty time-dependent function whereas the second one, handles a strong dynamical constraint in which the dynamical system\u2019s coefficients  constitute the control variables. Both choices correspond to different approximations of the relation between the reduced basis on which is expressed the motion field and the basis components that have been neglected in the reduced order model construction.  The techniques have been assessed on numerical data and for real experimental conditions with noisy particle image velocimetry data.","palabras_clave":"Reduced order models"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89390,"idioma_id":4,"titulo":"Similarity analysis of a glottal like jet","resumen":"This work discloses similarity properties of ahigh-aspect-ratio pulsating jet with lateral confinementexhibiting axis switching in a region close to the jet exit.The analysis is conducted separately within the major andminor planes of the jet source. The similarity relationsderived from the in-plane flow equations are combinedwith experimental data collected in a recent three-dimensionalvelocimetry study of a glottal-like jet. Empirically,non-collapsing profiles are shown to rescale as collapsingprofiles in the similarity variables within ranges of thestreamwise coordinate, which are determined by the analysis.The similarity properties are shown to be useful tomake predictions on the jet axis-switching characteristics.","palabras_clave":"Self similar flows"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89391,"idioma_id":5,"titulo":"Habilidades para la Vida en adolescentes: Factores Predictores de la Empatía","resumen":"El objetivo de esta investigación es indagar cómo se presentan las habilidades para la vida en los adolescentes e identificar las variables predictoras de la empatía. La muestra está constituida por 124 adolescentes escolarizados de 13 a 18 años de edad, 73 varones (59%) y 51 mujeres (41%) de una escuela pública de la Ciudad de Córdoba. El ANOVA muestra diferencias de género con respecto a algunas variables. Las mujeres presentan mayor ansiedad- timidez, empatía, autoconcepto social y conducta sumisa\/ pasiva. El análisis correlacional indica relaciones significativas entre las diferentes variables que miden las habilidades interpersonales y de comunicación (los adolescentes con alta puntuaciones en consideración por los demás, presentan altas puntuaciones en autocontrol, altruismo, empatía, asertividad, liderazgo. En tanto aquellos adolescentes que exteriorizan baja consideración por los demás presentan mayor retraimiento y conducta agresiva). Se presentan además correlaciones positivas entre las variables que miden las habilidades interpersonales y de comunicación (autocontrol, altruismo, empatía, conducta asertiva) y habilidades para el control de las emociones (autoconcepto en sus dimensiones familiar y social y académico); así como correlaciones positivas entre las habilidades interpersonales y de la comunicación (conducta asertiva, empatía y altruismo) con habilidades cognitivas (estrategias asertivas). Por último el análisis de regresión múltiple identificó como predictoras de la empatía la conducta de consideración por los demás, el autoconcepto social, la conducta agresiva y el autoconcepto académico.","palabras_clave":"Habilidades para la vida|Adolescentes |Empatía"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89392,"idioma_id":5,"titulo":"Estudio de las Propiedades Físicas y de la Cinética de Secado de Granos de Maíz Colorado Duro","resumen":"Se estudió el efecto de la humedad sobre propiedades físicas de Maíz  Colorado Duro en el rango 17-35% base seca, y la cinética de  secado para temperaturas entre 30-90°C y velocidad  de 0.43 m\/s. La humedad tuvo efecto significativo positivo sobre la longitud  (12.059 x 10-3 - 12.91 x 10-3 m),  diámetro geométrico (7.8 x 10-3 - 8.281 x 10-3  m), diámetro equivalente (8.18 x 10-3 - 8.63 x 10-3m), peso de mil granos (363.6 - 421.9 g) y ángulo de reposo (10.11 - 24.66°), y efecto negativo sobre las densidades aparente  (0.801 - 0.684 g\/mL) y real (1.339 - 1.170 g\/mL), pero el ancho, espesor, porosidad y  esfericidad no se vieron significativamente afectados. El secado ocurrió en el  período de velocidad decreciente, siendo el tiempo y la temperatura variables  significativas sobre la humedad del grano. Los modelos de Page, Difusivo de  tiempos cortos y una modificación introducida a éste ultimo resultaron  adecuados (R2&gt;0.99) para describir los datos. Los coeficientes de  difusión estuvieron entre 1.907 x 10-11 y 6.495 x 10-11 m2\/s,  y la energía de activación fue 17.74 kJ\/mol.","palabras_clave":"SECADO|PROPIEDADES FÍSICAS|COEFICIENTE DE DIFUSIÓN|MAÍZ COLORADO DURO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89393,"idioma_id":5,"titulo":"Impacto del programa de educación para la promoción de la salud auditiva en los adolescentes","resumen":"En el presente trabajo se describen las actividades llevadas a cabo a partir de la aplicación del Programa de Educación para la Promoción de la Salud Auditiva en Adolescentes y el impacto obtenido. El Programa mencionado se enmarca dentro del área de extensión a la comunidad de la línea de Conservación de la Audición en los Adolescentes del Centro de Investigación y Transferencia en Acústica (CINTRA) - Unidad Asociada a CONICET. La implementación del mismo se realizó durante el período 2010- 2011 con alumnos de 4º año del Ciclo de Especialización pertenecientes a dos escuelas secundarias de la ciudad de Córdoba, con el principal objetivo de desarrollar y aplicar estrategias de prevención de riesgos y promoción de la salud auditiva a través de la capacitación de Jóvenes Promotores de Salud Auditiva, aplicando la metodología de talleres. Se administraron cuestionarios estandarizados, entrevistas personales y observaciones directas en ambas instituciones con el propósito de evaluar la eficacia del programa de intervención, las actitudes que tienen los adolescentes hacia la música y el estado de conocimiento sobre la Salud Auditiva. ","palabras_clave":"Habilidades para la vida |Promoción de la salud |Adolescentes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89394,"idioma_id":5,"titulo":"Patrones de Flujo en Reactores Químicos: Desarrollo de Modelos Matemáticos y Numéricos Basados en CFD","resumen":"En el mundo real muchas veces el comportamiento de los reactores químicos es muy diferente del que describen los modelos ideales. Las desviaciones del comportamiento ideal pueden originarse por la formación de canalizaciones, recirculación o por formación de zonas estancadas. El conocimiento del comportamiento de los reactores reales permite ajustar los modelos ideales de manera que puedan describir más realísticamente los procesos químicos. Los problemas del flujo no ideal están íntimamente relacionados con el cambio de escala; la decisión de si ha de ensayarse o no en planta piloto depende del control que se tenga sobre las variables más importantes del proceso. A menudo, el factor no controlable en el cambio de escala es la magnitud de la no idealidad del flujo; con frecuencia este factor difiere ampliamente entre las unidades grandes y las pequeñas; por consiguiente, el desconocimiento de este factor puede conducir a grandes errores en el diseño. Para predecir las conversiones y la distribución de productos en los reactores reales resulta necesario un modelo de patrones de flujo. Una forma de evaluar cuánto tiempo permanece cada una de las moléculas en el recipiente es determinar la Distribución de Tiempos de Residencia (DTR) mediante un método de investigación ampliamente difundido: el método experimental estímulo-respuesta. La DTR muestra las condiciones hidrodinámicas que ocurren en los reactores. En base esos resultados se establecen hipótesis que permitan reproducir el comportamiento del reactor químico a través de modelos matemáticos y\/o numéricos. Un nuevo y reciente enfoque a este problema es el uso de la dinámica de fluidos computacional (CFD) que permite modelar los patrones de flujo de fluidos contribuyendo a mejorar la comprensión del sistema y a optimizar el diseño. El objetivo de este trabajo es caracterizar la hidrodinámica y desarrollar un modelo matemático y\/o numérico (CFD) de un reactor utilizado para la obtención de biodiesel, perteneciente a la Planta Piloto de Reacción  de la Facultad de Ingeniería (UNCPBA). Se estudia experimentalmente el comportamiento del flujo del reactor mediante la técnica de estímulo-respuesta, utilizando una solución patrón salina coloreada con conductividad eléctrica conocida, evaluándose la respuesta a señales conocidas, bajo diferentes condiciones de operación. Los resultados son evaluados estadísticamente para lograr la caracterización del reactor desde el punto de vista hidráulico a través de modelos matemáticos (combinación de reactores ideales de tanque agitado continuo en serie, de dispersión de flujo) y de modelos numéricos (método de los elementos finitos, CFD), evaluando su aproximación al comportamiento real del reactor para la validación del modelo.","palabras_clave":"PATRONES DE FLUJO|REACTORES QUIMICOS|CFD|DISTRIBUCION DE TIEMPOS DE RESIDENCIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89395,"idioma_id":5,"titulo":"ENSEÑANDO EL METODO DE LOS ELEMENTOS FINITOS MEDIANTE UNA ACTIVIDAD TEORICO-PRACTICA INTEGRADORA","resumen":"Se presenta el desarrollo de una actividad pedagógica llevada a cabo como trabajo final del  Curso de Posgrado ?Teoría y aplicación práctica del Método de los Elementos Finitos en el análisis  estructural y térmico? en el marco del Doctorado en Ingeniería de la Facultad de Ingeniería de la  Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). El curso de posgrado está planteado en forma interdisciplinaria. El desarrollo del curso contempla, inicialmente, un  paralelismo entre la utilización de un software educativo (ED-ELAS2D) que reproduce fielmente el entorno de una clase en la que se lleva a cabo el análisis teórico y la resolución analítica de problemáticas relacionadas con la mecánica de sólidos aplicando el Método de los Elementos Finitos (MEF). Esta estrategia permite la comprensión gradual de la metodología, afianzando la  internalización de los conceptos y de la mecánica del MEF. Sobre esta base se presenta luego una analogía entre el enfoque del análisis estructural y el de otros problemas como el de transferencia de calor, utilizándose para su resolución otros paquetes de software (ALGOR, ANSYS). El uso del  primer programa educativo tiene como objetivo comprender en profundidad la mecánica de cálculo del método, mientras que los restantes pretenden mostrar su potencialidad para resolver problemas de mayor complejidad. La estrategia de evaluación consiste en desarrollar un trabajo integrador grupal por parte de los alumnos. Esta actividad radica en el abordaje de dos problemáticas de diferentes disciplinas de la ingeniería que los alumnos deben resolver haciendo uso de conceptos teóricos del MEF impartidos en las clases teóricas; adicionando la aplicación de la  erramienta computacional mediante la implementación de dichas problemáticas en el software educativo y otros paquetes comerciales. Finalmente, los resultados de la actividad evaluativa y de una encuesta de satisfacción realizada a los alumnos, permitió al equipo docente calificar a esta experiencia como muy exitosa, la cual podría transmitirse a otros docentes mediante jornadas de capacitación con el objetivo de mejorar su práctica en la enseñanza de estos métodos.","palabras_clave":"ENSEÑANZA|ACTIVIDAD TEÓRICO-PRÁCTICA|MÉTODO DE LOS ELEMENTOS FINITOS|POSGRADO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89396,"idioma_id":5,"titulo":"Evaluación económica del tratamiento de diabetes tipo 2  con saxagliptina en Colombia","resumen":"Objetivo:  Determinar la relación costo efectividad incremental del agregado de saxagliptina o sulfonilureas en Colombia a personas con DMT2 que no logran alcanzar metas glucémicas con metformina, durante un período máximo de 20 años.  Metodología:  Se realizó un estudio de costo   efectividad, utilizando un modelo de simulación de eventos discretos con incremento de tiempo fijo Diabetes Cardiff Model). Las características de la cohorte de pacientes y el perfil de eficacia para cada tratamiento se obtuvieron de la literatura. El costo de los medicamentos se obtuvo de SISMED y Farmaprecios. Los costos de los eventos macro y microvasculares se basaron en el POS, Manual Tarifario SOAT y consulta con experto local. La tasa de descuento en costos y beneficios fue 3,5%. Resultados:  En el grupo tratado con saxagliptina registramos menos eventos fatales y no fatales y menos episodios de hipoglucemia. En ambas estrategias los mayores costos correspondieron a los medicamentos, seguidos por los asociados al tratamiento del infarto de miocardio. El costo incremental de la terapia con saxagliptina fue de US$ 555.552 a 20 años. El tratamiento con saxagliptina redundó en un mayor número de Años de Vida Ajustados por Calidad (AVAC) y Años de Vida Ganados (AVG), respecto al obtenido con sulfonilureas. El costo por AVAC fue de US$ 2.190. Los   resultados de costo efectividad fueron robustos al análisis de sensibilidad. Conclusión: El agregado de saxagliptina a pacientes que no logran un control glucémico adecuado con metformina, es muy costo   efectiva comparada con el agregado de sulfonilureas.","palabras_clave":"diabetes tipo 2|tratamiento|saxagliptina|costo-efectividad"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89397,"idioma_id":4,"titulo":"Poly(o-aminophenol) film electrodes. Synthesis and characterization. Formation mechanisms. A review article","resumen":"This review, which is divided into three parts, concerns electrochemical synthesis, spectroscopic characterization and formation mechanisms of poly(o-aminophenol) (POAP) film electrodes.  The first part of this review is devoted to describe the electropolymerization process of o-aminophenol on different electrode materials and in different electrolyte media by employing both potentiodynamic and potentiostatic methods. The evolution of the voltammogram during the electrosynthesis of POAP and the assignation of the voltammetric peaks to different species, according to the formation mechanism formulated by each author, are described. The effects of some chemical substances and electrochemical pretreatments of the electrode surface, on the electropolymerization process of o-aminophenol are also considered in this part of the review. The synthesis of POAP in neutral media, which yields a nonconducting polymer, and its use as component of biosensors and protective layer in corrosion processes, are analyzed at the end of this first part. The second part of this review refers to spectroscopic studies carried out by different authors to both, identify the products of the o-aminophenol electrooxidation and elucidate the chemical structure of poly(o-aminophenol) film electrodes. This second part of the review also describe the different spectroscopic methods employed to study the redox process of POAP, which allowed to demonstrate existence of transient species during the transition of the completely oxidized form of POAP to the completely reduced one.  The third part of this review shows the different mechanisms formulated to interpret the POAP films formation from both acid and basic solutions of o-AP. Also, some electrochemical and spectroscopic data which allowed to propos the corresponding formation mechanisms, especially in basic media, are described.","palabras_clave":"POAP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89398,"idioma_id":4,"titulo":"Spectroscopic characterization of poly(o-aminophenol) film electrodes   A review article","resumen":"This paper refers to spectroscopic studies carried out to identify the products of o-aminophenol electro-oxidation and elucidate the structure of electrochemically synthesized poly(o-aminophenol) (POAP) films. Spectroscopic studies of the redox conversion of POAP are also reviewed.","palabras_clave":"POAP|Electroquímica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89399,"idioma_id":4,"titulo":"Formation of an extended CoSi2 thin nanohexagons array coherently buried in silicon single crystal","resumen":"A Co&#8208;doped silica film was deposited on the surface of a Si(100) wafer   and isothermally annealed at 750&#8201;°C to form spherical Co nanoparticles   embedded in the silica film and a few atomic layer thick CoSi2   nanoplatelets within the wafer. The structure, morphology, and spatial   orientation of the nanoplatelets were characterized. The experimental   results indicate that the nanoplatelets exhibit hexagonal shape and a   uniform thickness. The CoSi2   nanostructures lattice is coherent with the Si lattice, and each of them   is parallel to one of the four planes belonging to the {111}   crystallographic form of the host lattice.","palabras_clave":"annealing|cobalt|nanofabrication|thin films"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89400,"idioma_id":4,"titulo":"Study of Nucleation and Growth Mechanism of the Metallic Nanodumbbells","resumen":"We propose a general nucleation and growth model thatcan explain the mechanism of the formation of CoPt3\/Au, FePt\/Au, andPt\/Au nanodumbbells. Thus, we found that the nucleation event occurs as a result of reduction of Au+ ions by partially oxidized surface Pt atoms. In cases when Au3+ is used as a gold precursor, the surface of seeds should be terminated by ions (e.g., Co2+, Pb2+) that can reduce Au3+ to Au+ ions, which can further participate in the nucleation of gold domain. Further growth of gold domain is a result of reduction of both Au3+ and Au+ by HDA at the surface of gold nuclei. We explain the different ability of CoPt3, Pt, and FePt seeds to serve as a nucleation center for the reduction of gold and further growth of dumbbells. We report that the efficiency and reproducibility of the formation of CoPt3\/Au, FePt\/Au, and Pt\/Au dumbbells can be optimized by the concentration and oxidation states of the surface ions on metallic nanocrystals used as seeds as well as by the type of the gold precursor.","palabras_clave":"multicomponent nanostructures|nanoparticles|catalytic properties|xafs"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89401,"idioma_id":4,"titulo":"Effects of perinatal asphyxia on rat striatal cytoskeleton","resumen":"Perinatal asphyxia (PA) is a medical condition associated with a high short-term morbimortality and different long term neurological diseases. In previous works, we have shown that neuronal and synaptic changes in rat striatum lead to ubi-protein accumulation in post-synaptic density (PSD) after six months of sub-severe PA. However, very little is known about the synaptic and related structural modifications induced by PA in young rats. In the present work, we studied neuronal cytoskeleton modifications in striatum induced by sub-severe PA in 30 days-old rats. We observed a significant decrease in the number of neurons, in particular calbindin immunoreactive neurons after PA. In addition, it was also observed that actin cytoskeleton was highly modified in the PSD as well as an increment of F-actin staining by Phalloidin-alexa488 in the striatum of PA rats. Using correlative fluorescence-electron microscopy photooxidation, we confirmed and extended confocal observations. F-actin staining augmentation was mostly related with an increment in the number of mushroom-shaped spines. Consistent with microscopic data, Western blot analysis revealed a &#946;-actin increment in PSD in PA rats. On the other hand, MAP-2 immunostaining was decreased after PA, being NF-200 expression unmodified. Although neuronal death was observed, signs of generalized neurodegeneration were absent. Taken together these results showed early post-synaptic F-actin cytoskeleton changes induced by PA with slightly modifications in the other components of the neuronal cytoskeleton, suggesting that F-actin accumulation in the dendritic spines could be involved in the neuronal loss induced by PA.","palabras_clave":"STRIATUM|PERINATAL ASPHYXIA|MAP-2|NEURONAL CYTOSKELETON|DENDRITIC SPINES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89402,"idioma_id":4,"titulo":"Effects of two commonly found strains of Influenza A virus on developing dopaminergic neurons, in relation to the pathophysiology of schizophrenia","resumen":"Influenza virus (InfV) infection during pregnancy is a known risk factor for neurodevelopment abnormalities in the offspring, including the risk of schizophrenia, and has been shown to result in an abnormal behavioral phenotype in mice. However, previous reports have concentrated on neuroadapted influenza strains, whereas increased schizophrenia risk is associated with common respiratory InfV. In addition, no specific mechanism has been proposed for the actions of maternal infection on the developing brain that could account for schizophrenia risk. We identified two common isolates from the community with antigenic configurations H3N2 and H1N1 and compared their effects on developing brain with a mouse modified-strain A\/WSN\/33 specifically on the developing of dopaminergic neurons. We found that H1N1 InfV have high affinity for dopaminergic neurons in vitro, leading to nuclear factor kappa B activation and apoptosis. Furthermore, prenatal infection of mothers with the same strains results in loss of dopaminergic neurons in the offspring, and in an abnormal behavioral phenotype. We propose that the well-known contribution of InfV to risk of schizophrenia during development may involve a similarspecific mechanism and discuss evidence from the literature in relation to this hypothesis.","palabras_clave":"INFLUENZA VIRUS|DOPAMINERGIC NEURONS|APOPTOSIS|NEURAL DEVELOPMENT|MATERNAL INFECTION|SCHIZOPHRENIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89403,"idioma_id":4,"titulo":"Phototropins but not cryptochromes mediate the blue light-specific promotion of stomatal conductance, while both enhance photosynthesis and transpiration under full sunlight","resumen":"Leaf epidermal peels of Arabidopsis (Arabidopsis thaliana) mutants lacking either phototropins 1 and 2 (phot1 and phot2) or  cryptochromes 1 and 2 (cry1 and cry2) exposed to a background of red light show severely impaired stomatal opening  responses to blue light. Since phot and cry are UV-A\/blue light photoreceptors, they may be involved in the perception of the  blue light-speci&#64257;c signal that induces the aperture of the stomatal pores. In leaf epidermal peels, the blue light-speci&#64257;c effect  saturates at low irradiances; therefore, it is considered to operate mainly under the low irradiance of dawn, dusk, or deep  canopies. Conversely, we show that both phot1 phot2 and cry1 cry2 have reduced stomatal conductance, transpiration, and  photosynthesis, particularly under the high irradiance of full sunlight at midday. These mutants show compromised responses  of stomatal conductance to irradiance. However, the effects of phot and cry on photosynthesis were largely nonstomatic. While  the stomatal conductance phenotype of phot1 phot2 was blue light speci&#64257;c, cry1 cry2 showed reduced stomatal conductance not  only in response to blue light, but also in response to red light. The levels of abscisic acid were elevated in cry1 cry2. We  conclude that considering their effects at high irradiances cry and phot are critical for the control of transpiration and  photosynthesis rates in the &#64257;eld. The effects of cry on stomatal conductance are largely indirect and involve the control of  abscisic acid levels.","palabras_clave":"phototropin|cryptochrome|stomata|transpiration"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89404,"idioma_id":4,"titulo":"The cyclophilin ROC1 links phytochrome and cryptochrome to brassinosteroid sensitivity","resumen":"Although multiple photoreceptors converge to control common aspects of seedling de-etiolation, we are relatively ignorant of the genes acting at or downstream of their signalling convergence. To address this issue we screened for mutants under a mixture of blue plus far-red light and identified roc1-1D. The roc1-1D mutant, showing elevated expression of the ROTAMASE CYCLOPHILIN 1 (ROC1\/AtCYP18-3) gene, and partial loss-of function roc1 alleles, has defects in phytochrome A (phyA)-, cryptochrome 1 (cry1)- and phytochrome B (phyB)-mediated de-etiolation, including long hypocotyls under blue or far-red light. These mutants show elevated sensitivity to brassinosteroids in the light but not in the dark. Mutations at brassinosteroid signalling genes and the application of a brassinosteroid synthesis inhibitor eliminated the roc1 and roc1-D phenotypes. The roc1 and roc1-D mutants show altered patterns of phosphorylation of the transcription factor BES1, a known point of control of sensitivity to brassinosteroids, which correlate with the expression levels of genes directly targeted by BES1. We propose a model where perception of light by phyA, cry1 or phyB activates ROC1 (at least in part by enhancing its expression). This in turn reduces the intensity of brassinosteroid signalling and fine-tunes seedling de-etiolation.","palabras_clave":"ROTAMASE CYCLOPHILIN 1|cryptochrome|phytochrome|brassinosteroid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89405,"idioma_id":4,"titulo":"cry1 and GPA1 signaling genetically interact in hook opening and anthocyanin synthesis in Arabidopsis","resumen":"While studying blue light-independent effects of cryptochrome 1 (cry1) photoreceptor, we observed premature opening of the hook in cry1 mutants grown in complete darkness, a phenotype that resembles the one described for the heterotrimeric G-protein &#945; subunit (GPA1) null mutant gpa1. Both cry1 and gpa1 also showed reduced accumulation of anthocyanin under blue light. These convergent gpa1 and cry1 phenotypes required the presence of sucrose in the growth media and were not additive in the cry1 gpa1 double mutant, suggesting context-dependent signaling convergence between cry1 and GPA1 signaling pathways. Both, gpa1 and cry1 mutants showed reduced GTP-binding activity. The cry1 mutant showed wild-type levels of GPA1 mRNA or GPA1 protein. However, an anti-transducin antibody (AS\/7) typically used for plant G&#945; proteins, recognized a 54 kDa band in the wild type but not in gpa1 and cry1 mutants. We propose a model where cry1-mediated post-translational modification of GPA1 alters its GTP-binding activity.","palabras_clave":"GPA1|cryptochrome|Arabidopsis|photomorphogenesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89406,"idioma_id":4,"titulo":"Diurnal Dependence of Growth Responses to Shade in Arabidopsis: Role of Hormone, Clock, and Light Signaling","resumen":"We investigated the diurnal dependence of the hypocotyl-growth responses to shade under sunlight\u2013night cycles in Arabidopsis thaliana. Afternoon shade events promoted hypocotyl growth, while morning shade was ineffective. The lhy-D, elf3, lux, pif4 pif5, toc1, and quadruple della mutants retained the response to afternoon shade and the lack of response to morning shade while the lhy cca1 mutant responded to both morning and afternoon shade. The phyB mutant, plants overexpressing the multidrug resistance-like membrane protein ABCB19, and the iaa17\/axr3 loss-of-function mutant failed to respond to shade. Transient exposure of sunlight-grown seedlings to synthetic auxin in the afternoon caused a stronger promotion of hypocotyl growth than morning treatments. The promotion of hypocotyl growth by afternoon shade or afternoon auxin required light perceived by phytochrome A or cryptochromes during the previous hours of the photoperiod. Although the ELF4\u2013ELF3\u2013LUX complex, PIF4, PIF5, and DELLA are key players in the generation of diurnal hypocotyl-growth patterns, they exert a minor role in the control of the diurnal pattern of growth responses to shade. We conclude that the strong diurnal dependency of hypocotyl-growth responses to shade relates to the balance between the antagonistic actions of LHY\u2013CCA1 and a light-derived signal.","palabras_clave":"diurnal rhythms|circadian clock|shade|auxin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89407,"idioma_id":5,"titulo":"Mapeo de desmontes en áreas de bosque nativo de la provincia de Entre Ríos, Argentina","resumen":"        El  objetivo de este trabajo fue evaluar la aplicación de una metodología de  detección y monitoreo de los desmontes, resistente a la irregularidad de la  adquisición de imágenes en la región del Espinal entrerriano. El monitoreo de  los cambios de uso y cobertura de las tierras es actualmente necesario para la  política gubernamental de manejo y conservación de los recursos naturales. El  área de estudio fue el Departamento Feliciano al norte de la Provincia de Entre  Ríos, Región noreste de Argentina. La vegetación es la típica formación arbórea  del Espinal entrerriano sometido a la actividad ganadera extensiva. La  metodología usó imágenes Landsat TM para formar un paquete multitemporal de  bandas espectrales de la imagen de la segunda fecha y una banda intensidad del  cambio obtenida por la técnica RCEN. Sobre este paquete se aplicó una técnica  de 'segmentación de imágenes por crecimiento de regiones' con  semillado manual. Finalmente, se realizó el agrupamiento temático basado en la  interpretación visual. En total fueron detectados 1680ha desmontadas entre  Agosto de 2009 y Diciembre de 2010, y 1140ha desmontadas entre Diciembre de 2010  y Abril de 2011. La segmentación de imágenes con bandas 'intensidad del  cambio' con semillado manual obtuvo buenos resultados para la detección de  desmontes. Este resultado fue corroborado por la fiscalización in situ de los  organismos gubernamentales.  ","palabras_clave":"MONITOREO|BOSQUES|TELEDETECCION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89408,"idioma_id":4,"titulo":"Photoinduced reduction of divalent mercury by quinones in  the presence of formic acid under anaerobic conditions","resumen":"The laser flash photolysis technique (kexc = 355 nm) was used to investigate the mechanism of the HgCl2 reduction mediated by CO 2 radicals generated from quenching of the triplet states of 1,4-naphthoquinone (NQ) by formic acid. Kinetic simulations of the experimental signals support the proposed reaction mechanism. This system is of potential interest in the development of UV-A photoinduced photolytic procedures for the treatment of Hg(II) contaminated waters. The successful replacement of NQ with a commercial fulvic acid, as a model compound of dissolved organic matter, showed that the method is applicable to organic matter-containing waters without the addition of quinones.","palabras_clave":"Triplet states|Naphtoquinone"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89409,"idioma_id":4,"titulo":"Evaluation of the Hg2+ binding potential of fulvic acids from fluorescence excitation-emission matrices","resumen":"The effect of Hg2+ on the fluorescence intensity of three fulvic acids (Pahokke Peat, Pony Lake and Suwanee River) was studied. The fluorescence intensity decreased in the presence of added Hg2+, while the fluorescence lifetimes were independent of the concentration of Hg2+ in solution. These results are indicative of ground-states association between the fulvic acids and Hg2+ with formation of stable non-fluorescent complexes (static quenching process). The analysis of the excitation-emission matrices with the Singular Value Decomposition (SVD) and Multivariate Curve Resolution - Alternating Least Squares (MCR-ALS) methods provided additional valuable information regarding the binding properties between Hg2+ ions and specific fluorescence components of the fulvic acids.             The three fulvic acids were shown to contain the same three groups of fluorophores characterized by excitation\/emission pairs in the following regions: (320-330 nm\/ 425-450 nm), (370-375 nm\/ 465-500 nm), (290-295 nm\/ 370-395 nm). These pairs are almost not affected by the change of pH from 2.0 to 7.0.             Ryan?Weber and modified Stern-Volmer methods were used to analyze the static fluorescence quenching of the individual components. Similar conditional stability constants of Hg2+ binding for the three components were found by both methods. The obtained logK values are in the range of 4.4 to 5.4.           ","palabras_clave":"FLUORESCENCES OF FULVIC ACID|MERCURY|EXCITATION-EMISSION MATRICES|MULTIVARIATE CURVE RESOLUTION-ALTERNATING LEAST SQUARES (MCR-ALS)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89410,"idioma_id":4,"titulo":"Salmonella enterica induces joint inflammation and the expression of IL-17 in draining lymph nodes early after the onset of enterocolitis in mice","resumen":"                In developing countries, one third of reactive arthritis (ReA)  cases are associated with Salmonella enterocolitis, nevertheless there is no animal model for  studying this pathology. Here we induced a self-limiting Salmonella enterica serovar Enteritidisenterocolitis in mice to analyze the onset  of ReA. BALB\/c mice received orally 20 &#956;g of streptomycin  24 h before intragastric inoculation of a low dose (3-4 x 103 CFU) of S. Enteritidis. In  response to Salmonella  infection, a 30-fold increase in the  expression of IL-17, measured by qPCR, was observed in mesenteric lymph nodes  5 days post infection.  At this time synovitis was already evident and concomitantly a significant increase  in joint TNF-&#945; was detected by ELISA. The early development of joint lesions was  accompanied by an increased expression of IL-17 in inguinal and popliteal  lymph nodes.  Infection with 107 CFU  of an isogenic &#916;invG mutant  bearing a defective TTSS-1 induced enterocolitis histologically similar to that  triggered by the wild type strain. Interestingly, despite the higher infective  dose used, the mutant did not trigger intestinal IL-17. Moreover, no synovitis  was observed in mice suffering &#916;invG enterocolitis.  Neutralization of IL-17 in  mice infected with S.  Enteritidis prevented both synovitis and the  increment of TNF-&#945; in the joints suggesting that IL-17 participates in the  generation of Salmonella-induced ReA through the induction of TNF-&#945; in the joints.","palabras_clave":"reactive arthritis (ReA)|Salmonella enterica |IL-17"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89411,"idioma_id":4,"titulo":"Synergistic antimicrobial effect against early biofilm formation:  micropatterned surface plus antibiotic treatment","resumen":"The detrimental effects of biofilms are a cause of great concern in medical, industrial and environmental areas. In this study, we proposed a novel eradication strategy consisting of the combined use of micropatterned surfaces and antibiotics on biofilms to reduce the rate of bacterial colonisation. Pseudomonas fluorescens biofilms were used to perform a comparative evaluation of possible strategies to eradicate these biological layers. First, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration of planktonic cultures were determined. Subsequently, adhesion of bacteria on microstructured gold surfaces (MS) with patterned features that were similar to the bacterial diameter as well as on smooth nanostructured gold (NS) was assessed. As expected, lower bacterial&nbsp; attachment as well as inhibition of bacterial aggregation were observed on MS. The effect of streptomycin treatment (ST) in the concentration range 1?4 mg\/L (0.25?1× MIC) on biofilms grown on MS and NS was also evaluated. The combined strategy involving the use of micropatterned surfaces and antibiotic treatment (MS + ST) to eradicate Pseudomonas biofilms was then investigated. Results showed a synergistic effect of MS + ST that yielded a reduction of &#8805;1000-fold in the number of surviving biofilm bacteria with respectto those obtained with single ST or MS. The combined strategy may be a significant contribution to the eradication of biofilms from different environments. In addition, the important role of early monolayer bacterial aggregates in increasing resistance to antimicrobial agents was demonstrated.","palabras_clave":"BACTERIAL ADHESION|ANTIMICROBIAL RESISTANCE|PATTERNED SURFACE|PSEUDOMONAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89412,"idioma_id":4,"titulo":"Caesalpinia spinosa tannin derivatives for antifouling formulations","resumen":"AFcoatings prevent the undesirable accumulation of a wide variety of marineorganisms (biofouling) on ship hulls can lead to significant increased costs,principally by increased fuel consumption. The bioactive compounds (biocides)used in antifouling coatings, like tributyltin (TBT), are banned for theirtoxic action towards non-target marine organisms. As a consequence, thedevelopment of alternative AF coatings with new natural products as biocidesinhibit is a key factor. In this approach, tara(Caesalpinia spinosa) tannin (TT) derivatives are being proposed as apromising solution.The aimof this research work was, primarily, to explore the possible application of anatural and abundant product, such as the TT, in the preparation of AFcoatings. So, two TT derivatives were obtained at &nbsp;different temperatures (20ºC and 60ºC) as immersion in naturalenvironments, the dissolution of TT from coatings in artificial sea water wasstudied. Antifouling paints with a soluble matrix were formulated and theiraction was assessed in natural sea water environment (Mar del Plata harbor).","palabras_clave":"ANTIFOULING COATINGS|TARA TANNIN|BIOCIDE|LEACHING RATE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89413,"idioma_id":4,"titulo":"Ceramic microspheres to improve anticorrosive performance of phosphate paints","resumen":"Zinc phosphate and related compounds have been proposed as green replacements for traditional anticorrosive pigments such as zincchromate and lead oxides. However, environmental concerns have risen in the last years because the disposal of these materials in the environmentincreased phosphate levels in water and produce eutrophication of water bodies. The present paper deals with the possible incorporation of ceramicmicrospheres in alkyd paints in order to diminish phosphate content. The results suggested that paints with low phosphate content can besuccessfully formulated with a suitable selection of the amount and type of microspheres.","palabras_clave":"ZINC PHOSPHATE|CERAMIC MICROSPHERES|ANTICORROSIVE PAINTS|BARRIER PROPERTIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89414,"idioma_id":4,"titulo":"'Quebracho' tannin derivative and boosters biocides for new antifouling formulations","resumen":"Abstract The growth of fouling communities on ships\u2019hulls causes economic losses due to increased fuelconsumption and to the deterioration of the metallicsubstrate by corrosion. Antifouling paints are formulatedto avoid the settlement of these organisms and maycontain biocides as active compounds. The objective ofthis research was to evaluate the antifouling performanceof paints formulated with a \u2018\u2018quebracho\u2019\u2019 tanninderivative (zinc \u2018\u2018tannate\u2019\u2019) and \u2018\u2018boosters\u2019\u2019 (secondarybiocides). The \u2018\u2018boosters\u2019\u2019 used in this study werebismuth lactate, a zeolite exchanged with silver cations,and the same zeolite modified with silver chloride.Bioassays with \u2018\u2018boosters\u2019\u2019 solutions were carried outemploying Artemia persimilis. Soluble matrix antifoulingpaints were formulated and their action was assessedin a natural sea water environment. Results showed thatthe bismuth lactate resulted in a coating with almosttriple service life of the antifouling paints with zinc\u2018\u2018tannate.\u2019\u2019 Paints formulated with the silver compositesbehaved slightly better than the control paint.","palabras_clave":"Coatings|Tannin|Biocides|Antifouling paints"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89415,"idioma_id":4,"titulo":"Do phosphate ions affect the biodegradation rate of fluoride-treated Mg?","resumen":"Previous studies have shown that pure Mg that is reinforced by powder metallurgy (Mg(PM)) is a promising biodegradable material, because it circumvents the drawbacks of the toxic components of Mg alloy implants. However, its degradation rate is high, which can be reduced with fluoride coatings (Mg(PM)F). This protective effect is temporary, because chloride induces further biodegradation of Mg(PM) in biological media. The aim of this report was to examine the effects of phosphates on Mg(PM)F in chloride-containing medium. By surface analysis of Mg(PM)F, the aggressive activity of chlorides induced a rapid decrease in F content of the layer. However, by electrochemical impedance spectroscopy and EDX, the surface attack was hindered in the presence of phosphates that precipitated onto the regions where localized attack occurred and formed a more protective P-containing layer. Our results highlight the robust activity of phosphates, which act synergistically with fluorides, controlling the degradation of F-coating in biological media and prolonging the service period of temporary Mg(PM)F implants.","palabras_clave":"Magnesium|phosphate|fluoride|Biomaterial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89416,"idioma_id":4,"titulo":"Large Amplitude Gravity Waves above the Southern Andes, the Drake Passage and the Antarctic Peninsula","resumen":"Above the Southern Andes Range and its prolongation in the  Antarctic Peninsula, large amplitude mountain and shear gravity  waves observed with Weather Research and Forecasting (WRF)  mesoscale model simulations during winter 2009 are analyzed. Two  specific reasons motivated this study: i) a decade of satellite  observations of temperature fluctuations in the stratosphere,  allowing to infer that this region may be launching the largest  amplitude gravity waves into the upper atmosphere and ii) a recent  design of a research Programme to investigate these features in  detail -Southern Andes ANtarctic GRavity wave InitiAtive  (SAANGRIA)-. The simulations are forced with Era-Interim data from  ECMWF. The approach selected for the regional downscaling is based  on consecutive integrations with weekly reinitialization with 24  hours of spin-up and the outputs during this period are excluded  from the analysis. From June 1 to August 31 2009, five case  studies were selected on the basis of their outstanding  characteristics and large wave amplitudes. In general, one or two  prevailing modes of oscillation are identified after applying  continuous wavelet transforms at constant pressure levels and  perpendicularly to the nominal orientation of the dominant wave  crests. In all cases, the dominant modes are characterized by  horizontal wavelengths around 50 km. Their vertical wavelengths,  depending on a usually strong background wind shear, are estimated  between 2 and 11 km. The corresponding intrinsic periods range  between 10 and 140 min. In general, the estimated vertical  wavelength (intrinsic period) maximizes (minimizes) around 250-300  hPa. The synoptic circulation for each case is described. Zonal  and meridional components of the vertical flux of horizontal  momentum are shown in detail for each case, including possible  horizontal wavelengths between 12 and 400 km. Large values of this  flux are observed at higher pressure levels, decreasing with  increasing height after a progressive deposition of momentum by  different mechanisms. As expected in the wintertime upper  troposphere and lower stratosphere in this region, a prevailing  zonal component is negative almost everywhere, with the exception  of one case above the northern tip of the Antarctic Peninsula. A  comparison with previous experimental results reported in the  region from in situ and remote sensing measurements, suggests a  good agreement with the momentum flux profiles computed from the  simulations. Partial wave reflection near the tropopause was  found, as considerable departures from equipartition between  potential and kinetic wave energy are obtained in all cases and at  all pressure levels. This ratio was always less than one below the  lower stratosphere.","palabras_clave":"MOUNTAIN WAVES|ANDESMOUNTAINS|PENINSULA ANTARCTICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89417,"idioma_id":4,"titulo":"Protected Areas Isolation in the Chaco Region, Argentina","resumen":"There is a general concern with regards to effectiveness of protected areas due to their progressive isolation caused by massive land use change in their surroundings. We examined the extent of natural vegetation fragmentation both within and around two protected areas over a period of 32 years, in the Argentine Chaco Region, in two contrasting ecoregions: Humid Chaco and Dry Chaco. We describe type and rate of change around each protected area, and discuss the potential implications for biodiversity conservation on the basis of a percolation\/connectivity model for two endemic species. The results show that the rate and type of land use change is unique in each study  area, and that the risk of isolation is imminent in both cases. This situation cancels the conservation objectives of protected areas, jeopardizing their effectiveness.","palabras_clave":"Areas Protegidas|Chaco Argentino|Fragmentación|Ecología de Paisajes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89418,"idioma_id":4,"titulo":"Quenching of the triplet state of safranine-O by aliphatic amines in AOT reverse micelles studied by transient absorption spectroscopy","resumen":"The photophysics of Safranine-O (3,6-diamino-2,7-dimethyl-5 phenyl phenazinium chloride) (SfH+Cl-) was investigated in reverse micelles (RMs) of AOT (sodium bis(2 ethylhexyl)sulfosuccinate) with special emphasis on the triplet state processes. The triplet is formed in its monoprotonated form, independently of the pH of the water used to prepare the RMs.While the intersystem crossing quantum yields in RMs are similar to those in organic solvents, the triplet lifetime is much longer. Since the pH in the water pool of AOT RMs is close to 5 and the triplet state of the dye is subjected to proton quenching, the long lifetime indicates that the dye resides in a region where it cannot be reached by protons during its lifetime. All the measurements indicate that the dye is localized in the interface, sensing a medium of micropolarity similar to EtOH : water (3 : 1) mixtures. The quenching by aliphatic amines was also investigated. While the quenching by the hydrophobic tributylamine is similar to that in methanol, the hydro-soluble triethanolamine is one order of magnitude more effective in RMs than in homogeneous solution. In the latter case the quenching process is interpreted by a very fast intramicellar quenching, the overall kinetics being controlled by the exchange of amine molecules between RMs. Semireduced dye is formed in the quenching process in RMs in the di-protonated state with a comparable quantum yield to the monoprotonated state formed in homogeneous solvents. The results point to the advantage of the reverse micellar system for the generation of active radicals for the initiation of vinyl polymerization, since a much lower concentration of amine can be employed with similar quantum yields.","palabras_clave":"Safranine|Reverse micelles|AOT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89419,"idioma_id":4,"titulo":"'Triplet State of 4-Methoxybenzyl Alcohol Chemisorbed on Silica Nanoparticles","resumen":"The knowledge of photochemical kinetics in colloidal systems is important in understanding environmental photochemistry on dispersed solid surfaces. As model materials for the chemically sorbed organic compounds present in natural environments, modi!ed silica nanoparticles (NPs) were obtained here by condensation of the silanol groups of fumed silica nanoparticles with 4-methoxybenzyl alcohol. These particles were characterized by different techniques. To evaluate their toxicity, the inhibition of the natural luminescence emission of the marine bacterium Vibrio !scheri in suspensions of the particles was measured. Laser 'ash-photolysis experiments (!exc = 266 nm) performed with NP suspensions inacetonitrile\u2013aqueous phosphate buffer mixtures showed the formation of the lowest triplet excited state of the chemisorbed organic groups (!max = 390 nm). DFT calculations of the absorption spectrum of this radical support the assignment. From the calculated triplet energy, a  thermodynamically favorable energy transfer from these triplet states to oxygen to yield singlet molecular oxygen is predicted. Avalue of 0.09was measured for the quantum yield of singlet molecular oxygen generation by air-saturated suspensions of the nanoparticles in the mixture of solvents acetonitrile\u2013aqueous phosphate buffer. The quantum yieldof singlet molecular oxygen generation by the free 4-methoxybenzyl alcohol in the same solvent is 0.31.","palabras_clave":"Silica|Nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89420,"idioma_id":4,"titulo":"Hydroxybutyrate prevents protein aggregation in the halotolerant bacterium Pseudomonas sp. CT13 under abiotic stress","resumen":"Polyhydroxybutyrate (PHB), a typical carbon and energy storage compound, is widely found in Bacteria and Archae domains. This polymer is produced in response to conditions of physiological stress. PHB is composed of repeating units of â-hydroxybutyrate (â-HB). It has been previously shown that â-HB functions as an osmolyte in extremophile strains. In this study, Pseudomonas sp. CT13, a halotolerant bacterium, and its PHB synthase-minus mutant (phaC) were used to analyze the chaperone role of â-HB. The production of this compound was found to be essential to salt stress resistance and positively correlated with salt concentration, suggesting that â-HB acts as a compatible solute in Pseudomonas sp. CT13. â-HB accumulation was also associated with the prevention of protein aggregation under combined salt and thermal stresses in Pseudomonas sp. CT13. Physiological concentrations of â-HB efficiently reduced citrate synthase (CS) aggregation and stabilized the enzymatic activities of CS during thermal stress. Docking analysis of the CS\/â-HB interaction predicted the stability of this complex under physiological concentrations of â-HB. Thus, in vivo, in vitro and in silico analyses suggest that â-HB can act as a chemical chaperone.","palabras_clave":"chemical chaperone|stress|protein aggregation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89421,"idioma_id":5,"titulo":"Paleoambiente y paleontología de la Formación Andapaico (Paleozoico superior, Precordillera Central, Argentina)","resumen":"A sedimentological, paleontological and paleoenvironmental study of the Andapaico Formation is presented (southern sector of the Paganzo Basin, San Juan). This unit overlies with an angular unconformity the Punta Negra Formation, and has a thickness of 430 m of siliciclastic sediments, that include deposits formed predominantly in nearshore environments. Lower shoreface (facies association I), anastomosed rivers and floodplain (II), high sinuosity rivers (III), beach (IV), eolian system (V), barrier island (VI) and lagoon (VII) deposits were identified. Facies association I (lower part of the unit) and VII (upper part) and their associated palynoflora assign them to the early Cisuralian (I) and late Cisuralian-early Guadalupian (VII, Lueckisporites-Weylandites Biozone). From the facies I association a fossil plant assemblage was obtained that allows it to be referred to the Ferugliocladus Superzone of the early Permian of the Tepuel-Genoa Basin, which reinforces the hypothesis of this age for the lower part of the Andapaico Formation.","palabras_clave":"Ambientes sedimentarios|Pérmico|Palinología|Paleobotánica|Formación Andapaico"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89422,"idioma_id":5,"titulo":"PALINOLOGÍA DE LA FORMACIÓN ANDAPAICO (CISURALIANO-GUADALUPIANO) PRECORDILLERA CENTRAL SANJUANINA (ARGENTINA): CONSIDERACIONES BIOESTRATIGRÁFICAS REGIONALES?","resumen":"Presented here is a palynological study of samples from the upper part of the Andapaico Formation, Precordillera of San Juan, Argentina. The samples are located just above the eolian facies and have been referred to the Lueckisporites-Weylandites Biozone (LW), probably the basal part, based on comparison with other palynofloras described for the Central-West basins of Argentina. The association is early Cisuralian-middle Guadalupian in age. In addition, 40 species are proposed to be included as new elements unique to the LW Biozone. Comparisons with coeval palynofloras of the Chacoparaná (Argentina), Paraná, and Amazonas (Brazil) biozones were made, showing a high degree of correspondence with the Striatites, Lueckisporites costabilis-Vittatina virkkiae and Vittatina costabilis biozones respectively. According to the botanical affinities of the elements identified in the association, it is possible to infer that they represent a mesophilic flora, with a low participation of hygro-hydrophilic elements, reflecting the absence of wet conditions in areas close to the site of deposition.","palabras_clave":"PALYNOLOGY|PERMIAN|ANDAPAICO FORMATION|SAN JUAN|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89423,"idioma_id":4,"titulo":"EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin","resumen":"NTRODUCTION:This study aimed to characterize the in vitro effect of EV-077, a compound that antagonises the binding of prostanoids and isoprostanes to the thromboxane receptor (TP) and inhibits the thromboxane synthase (TS), on platelet aggregation of patients with type-2 diabetes and coronary artery disease (CAD) on chronic aspirin treatment. The effect of EV-077 on 8-iso-PGE(2)-mediated TP receptor contraction of human arteries was also investigated.MATERIALS AND METHODS:Fifty-two type-2 diabetics with CAD on chronic aspirin (100mg) treatment were studied. Arachidonic acid-induced platelet aggregation was measured by impedance aggregometry in platelet-rich plasma (PRP) and whole blood anticoagulated with hirudin, and by light transmission aggregometry in citrate-anticoagulated PRP following 10-min in vitro exposure to EV-077 (100nmol\/l) or control. The effect of EV-077 was measured on isometric contraction of 24 human umbilical arteries induced by isoprostane 8-iso-PGE(2).RESULTS:Arachidonic acid (1mmol\/l) induced substantial aggregation in hirudin-anticoagulated whole blood (63±4AU), which was significantly reduced by in vitro exposure to EV-077 (38±3AU, P<0.001). Virtually no arachidonic acid-induced aggregation in citrate-anticoagulated or hirudin-anticoagulated PRP was observed. EV-077 potently, competitively and reversibly inhibited TP mediated contraction of umbilical arteries by 8-iso-PGE(2) (P<0.01).CONCLUSIONS:Aspirin did not completely inhibit arachidonic acid-induced platelet aggregation in whole blood from type-2 diabetics with CAD. This aggregation is likely induced by prostanoids and\/or isoprostanes produced by leukocytes, because it was significantly reduced by EV-077. The TP receptor-mediated contraction of human arteries induced by isoprostane 8-iso-PGE(2) was effectively inhibited by EV-077.","palabras_clave":"ARTERIAL CONTRACTION|ISOPROSTANE 8-ISO-PGE|PLATELET AGGREGATION|PROSTANOIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89424,"idioma_id":5,"titulo":"PHARMACOGENETICS IN PSYCHIATRY: HOW FAR ARE WE FROM CLINICAL APPLICATION?","resumen":"Pharmacogenetics studies how genetic variation influences the response ofpatients to drugs. This discipline has a greater impact in those medicalspecialties that treat complex diseases in which the therapeutic response isinsufficient and\/or have high costs such as psychiatry. This is a narrativereview in which we analyze the main results of pharmacogenetic studies performed with the most relevant groups of psychoactive drugs and discusses missing forincorporating these advances into our daily practice. We conclude that despitethe remarkable progress in the field of Pharmacogenetics in the last 10 years,studies in psychiatry have been inconclusive and the clinical use ofpharmacogenetic testing is still limited. However, there are some encouragingelements about the applicability of these tools for the improvement ofpsychiatric treatments.","palabras_clave":"FARMACOGENÉTICA|FARMACOGENÓMICA|PSIQUIATRÍA|ANTIPSICÓTICOS|ANTIDEPRESIVOS|ESTABILIZADORES DEL ÁNIMO|MEDICINA PERSONALIZADA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89425,"idioma_id":4,"titulo":"Severe Haemophilia A patients have reduced numbers of peripheral  memory B cells?","resumen":"The development of inhibitors is a complication of replacement treatment in Haemophilia. Loss of factor VIII-specific memory B cells in the spleen is associated with down regulation of antibodies in mice treated with high doses of FVIII, but changes in B cell memory have not been described in haemophilic patients. The aim of this study was to evaluate the phenotype of circulating lymphocytes in severe haemophilia A. Twenty patients with inhibitors (PI), 22 without inhibitors (P), nine patients during immune tolerance induction (ITI) treatment and 20 healthy donors (HD) were included. Peripheral blood lymphocytes were examined using flow cytometry. Anti-FVIII antibodies were measured using Bethesda and flow cytometry. Percentages of T subsets and B lymphocytes were similar in all groups. In contrast, memory B cells (CD27+) were decreased in PI and P compared with HD, but the level of significance was higher in PI (P = 0.001) than P (P = 0.01). PI with high level of anti-FVIII antibodies presented the lowest B memory values. CD70 expression was also lowest in PI. Non-switched CD27+ subpopulation (IgD+) was prevalent in PI, but did not show statistical significance. When ITI failed, the percentages of CD27+ B cells after 12 months of ITI were lowest. In a longitudinal study performed in four patients, an increased percentage of CD27+ and CD70+ B cells during ITI was found. This work suggests that different peripheral lymphocyte markers, such as CD27 and CD70 on B cells, may be helpful to evaluate anti-FVIII response and to monitor the success of ITI","palabras_clave":"anti-FVIII antibodies|haemophilia|memory B cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89426,"idioma_id":4,"titulo":"Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales","resumen":"Many natural phenomena display \u201Cself-organized criticality\u201D (SOC), (Bak et al., 1987). This  refers to spatially extended systems for which patterns of activity characterized by different  lengthscales can occur with a probability density that follows a power law with pattern  size. Differently from power laws at phase transitions, systems displaying SOC do not  need the tuning of an external parameter. Here we analyze intracellular calcium (Ca2+) 2+  signals, a key component of the signaling toolkit of almost any cell type. Ca\tsignals  can either be spatially restricted (local) or propagate throughout the cell (global). Different  models have suggested that the transition from local to global signals is similar to that of  directed percolation. Directed percolation has been associated, in turn, to the appearance  of SOC. In this paper we discuss these issues within the framework of simple models  2+ of Ca\tsignal propagation. We also analyze the size distribution of local signals (\u201Cpuffs\u201D)  observed in immature Xenopus Laevis oocytes. The puff amplitude distribution obtained from observed local signals is not Gaussian with a noticeable fraction of large size events. The experimental distribution of puff areas in the spatio-temporal record of the image has a long tail that is approximately log-normal. The distribution can also be fitted with a power law relationship albeit with a smaller goodness of fit. The power law behavior is encountered within a simple model that includes some coupling among individual signals for a wide range of parameter values. An analysis of the model shows that a global elevation of the Ca2+ concentration plays a major role in determining whether the puff size distribution is long-tailed or not. This suggests that Ca2+-clearing from the cytosol is key to determine whether IP3-mediated Ca2+ signals can display a SOC-like behavior or not.","palabras_clave":"calcium signals|self-organized criticality|percolations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89427,"idioma_id":4,"titulo":"Hypothyroidism: age-related influence on cardiovascular nitric oxide system in rats","resumen":"This study investigates whether changes in nitric oxide (NO) production participate in the cardiovascular manifestations of hypothyroidism and whether these changes are age-related. Sprague-Dawley rats aged 2 and 18 months old were treated with 0.02% methimazole (wt\/vol) during 28 days. Left ventricular function was evaluated by echocardiography. Measurements of arterial blood pressure, heart rate, nitric oxide synthase (NOS) activity and NOS\/caveolin-1 and -3 protein levels were performed. Hypothyroidism enhanced the age-related changes in heart function. Hypothyroid state decreased atrial NOS activity in both young and adult rats, associated with a reduction in protein levels of the three NOS isoforms in young animals and increased caveolin (cav) 1 expression in adult rats. Ventricle and aorta NOS activity increased in young and adult hypothyroid animals. In ventricle, changes in NOS activity were accompanied by an increase in inducible NOS isoform in young rats and by an increase in caveolins expression in adult rats. Greater aorta NOS activity level in young and in adult Hypo rats would derive from the inducible and the endothelial NOS isoform, respectively. Thyroid hormones would be one of the factors involved in the modulation of cardiovascular NO production and caveolin-1 and -3 tissue-specific abundance, regardless of age. Hypothyroidism appears to contribute in a differential way to aging-induced changes in the myocardium and aorta tissues. Low thyroid hormones levels would enhance the aging effect on the heart. Age-related changes in NO production participate in the cardiovascular manifestations of hypothyroidism.","palabras_clave":"THYROID DISORDERS|AGEING|AORTA |HEART"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89428,"idioma_id":4,"titulo":"Salt-induced downregulation of renal aquaporins is prevented by losartan","resumen":"Abstract AIMS: The purpose of this study was to investigate the expression of aquaporin-1 (AQP-1) and aquaporin-2 (AQP-2) in the renal tubule of rats fed with a high-salt diet and its modulation by the AT1 receptor blocker losartan.MAIN METHODS: The experiments were performed in four groups of rats fed for 3 weeks with the following diets: regular rat chow (NS); high-salt (8% NaCl) chow (HS), NS plus losartan (NS-L) and HS plus losartan (HS-L). Losartan (40 mg x kg(-1)) was administered in the drinking water. Systolic blood pressure (SBP) and renal function were evaluated. The intrarenal levels of angiotensin II (Ang II), TGF-â(1), á-smooth muscle actin (á-SMA), endothelial nitric oxide synthase (eNOS), AQP-1 and AQP-2 were determined by immunohistochemistry. AQP-1 and AQP-2 protein levels were measured by western blot analysis.KEY FINDINGS: A high-sodium diet downregulated AQP-1 and AQP-2 expression levels in the proximal tubule and collecting duct, respectively. The high-sodium diet also induced Ang II, TGF-â(1) and á-SMA overexpression and decreased eNOS expression in the renal cortex and medulla. Losartan increased the diuresis and natriuresis, favoring urinary sodium concentration. Additionally, losartan prevented the profibrogenic response, decreasing Ang II, TGF-â(1) and á-SMA levels and normalizing AQP-2 expression in the HS-L group. AQP-1 expression was upregulated by losartan in both the NS-L and HS-L groups.SIGNIFICANCE: These results show that increased intrarenal Ang II in rats fed with a high-salt diet downregulates renal AQP-1 and AQP-2 expressions. In addition, although losartan increased diuresis and natriuresis, it prevented the downregulation of aquaporins, favoring urinary sodium concentration","palabras_clave":"RIÑON|ACUAPORINAS |LOSARTAN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89429,"idioma_id":4,"titulo":". What behavior tells us about reproductive strategies in two lizard species of Liolaemus (Iguania: Liolaemidae).","resumen":"Several factors may be involved in determining behaviors associated to reproduction in different animals. Among these, where an animal lives and what it eats can give us some clues. Here we present results from three different projects on home ranges, nuptial coloration, and diet, in two lizard species of Liolaemus, and how they relate to reproductive behavior.     The study of how a species is distributed in its habitat may give insight into reproductive strategies being used by males and females. For the past 10 years, we have been following a population of L. quilmes at a site called Los Cardones (2725 m), in northwestern Argentina. This species is diurnal, oviparous and mainly insectivorous. Males are a little larger and more colorful than females. To determine their home ranges, lizards were marked with colored beads on the base of the tail and released at the point of capture. A grid of 75 x 100 m was traced in their natural habitat. Periodic censuses were conducted during austral Springs (reproductive season) and Summers (post-reproductive season), approximately 3 to 4 days each month, recording the coordinates of each lizard that was sighted. We calculated the home ranges or activity areas using the minimum convex polygon method, for more than 70 males and more than 60 females. Some of our findings were:  - Males had significantly larger home ranges than females (six times more on average), a result reported for many other lizard species.   - Core areas of home ranges, that area most frequently used by a lizard, of females did not overlap among each other whereas those of males overlapped 23 %. This meant females did not come into contact with each other but males could come in contact at home range borders where agonistic displays (headbobs, sideway presentation, arched inflated body) and occasional wrestling occured.   - Males whose home ranges were smaller than that of other males tended to overlap with only one female, indicating a possible monogamous strategy. Males with larger home ranges tended to overlap with two or more females, suggesting a polygynic strategy. Finally, in a third situation, two or three males overlapped with two or three females, indicating a polygynandric system.   - When males and females were tested on three different parameters (weight, color, and vicinity) in a choice situation in the laboratory, separately and together, neither males nor females showed preference for any of the parameters. This suggests that these lizards might not be using this type of information to choose a mate but instead may rely on other signals, such as chemical or behavioral, or a combination of these.     In another study, we explored female nuptial coloration, also in L. quilmes, and its relation to their reproductive state. Females of this species, as other closely related species of Liolaemus, exhibit what has been called nuptial coloration. Based on studies of other lizards, it has not always been clear whether this coloration indicated a receptive, a gravid, or a post-oviposition female. Females develop these colors on the sides of the neck, going from light yellow as they come out of hibernation in October to an intense orange by November and December, after which it gradually fades. We found that a light yellowish color, corresponded to early vitellogenesis, occurring at the beginning of Spring. When these colors turned to an intense orange, some females were in late vitellogenesis and others were pregnant. Once females had oviposited, this nuptial coloration was gradually lost. Interestingly matings occurred at the beginning of Spring when females were still in an early vitellogenic stage. Thus, females showed behavioural but not physiological receptivity. It is possible that courtship and mating helped activate the maturation of follicles and\/or that females might be able to store male sperm until vitellogenesis was completed. This would allow for a later fertilization of the eggs.     Finally we investigated diet preferences in L. crepuscularis looking for variations related to sex and reproductive condition. Liolaemus crepuscularis is a recently described species, belonging to the L. darwinii group as L. quilmes. It is an endemic viviparous species found only at high altitudes, above 2800 m, in the province of Catamarca, northwestern Argentina. Its biology and natural history are practically unknown although, unlike L. quilmes, the reproductive season occurs at the end of Summer, females being pregnant throughout Winter and giving birth in the Spring.     In many lizard species, diet will vary depending on the season but it also may be influenced by the reproductive condition of an individual. We investigated this question in L. crepuscularis, considering differences between males and females during the reproductive season and the post-reproductive season. Formicidae was the main prey item, as has been reported in many other Liolaemus species, but plant material was also important, especially at the end of the Summer when they also consumed the greatest amount of food. By the end of this season, males showed a great increase in testicular volume and females exhibited vitellogenic follicles. Males showed a positive tendency, although not significant, between food consumption and testicular volume. Since this occurred during their reproductive season, they may have needed the extra energy to court females and to ward off interested males. By the following Spring, testicular volume in males had decreased and females were gravid. A significant negative correlation was found in females between the amount of food consumed and pregnancy. They ate very little while pregnant, possibly in part due to the space occupied by the embryos as well as the possibly increased difficulty to forage, and vulnerability to predation.     These studies and others indicate that there is a great need for integrating studies of physiology and behavior to understand better the role of territoriality, nuptial coloration, or diet, in the dynamics of reproductive behavior.","palabras_clave":"LIZARDS|TERRITORIALITY|NUPTIAL COLORATION|DIET|REPRODUCTIVE BEHAVIOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89430,"idioma_id":4,"titulo":"Geographical and Botanical Classification of Honeys and Apicultural Products by Chemometric Methods. A Review","resumen":"The assessment of geographical and botanical origin is a topic of high interest around the world. This assessment is related to the international market of food raw materials. The chemometric tools appear as new analytical complements which, in recent years, were successfully used to determine the geographical and botanical origin of food raw materials or to detect possible adulterations. The classification can be possible using different analysis criteria, such as minor and trace elements, as well as sugars and other components by the chemometric analysis. This review covers all reported multivariate methods from January 1999 to February 2011, around the world, used for the classification and authentication of honey and apicultural products, for the geographical and botanical classification, as well as for the adulteration of honey and other apicultural products (as pollen and propolis). Topics are ordered in a way to allow easy reading and search of references.","palabras_clave":"HONEY|GEOGRAPHICAL-ORIGIN|BEE-PRODUCTS|PATTERN-RECOGNITION-METHODS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89431,"idioma_id":4,"titulo":"Development and characterization of edible chitosan\/olive oil emulsion films","resumen":"The properties of plasticized chitosan\u2013olive oil emulsion films prepared with increasing oil concentrations  were investigated. Emulsifying nature of chitosan was enough to stabilize olive oil droplets in the  film forming emulsions; hence homogeneous, thin and translucent films were obtained in all cases. The  homogeneity of the lipid globules distribution in the films was confirmed by contact angle measurements  and optical microscopy. All the tensile properties (Young Modulus, strength and maximum elongation)  increased with olive oil concentration and were explained considering the interactions developed  between lipid and carbohydrate phases in addition to the lubricant characteristics of the oil. Moisture  sorption, water vapor permeation through the films and effective diffusion coefficients decreased as oil  concentration increases, as a result of the non-polar nature of the lipid. Total soluble matter measurements  were used to confirm the development of strong associations between chitosan and olive oil.","palabras_clave":"Emulsion films|Chitosan|Olive oil"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89432,"idioma_id":4,"titulo":"COMPOSITE FILMS BASED ON SHAPE MEMORY POLYURETHANES AND NANOSTRUCTURED POLYANILINE OR CELLULOSE-POLYANILINE PARTICLES","resumen":"Conducting polyaniline (PANI) and PANI coated cellulose (PANI-NC) nanofibers doped with hydrochloric  acid were synthesized by a sonochemical method and re-dispersed in methyl isobutyl ketone  (MIBK) by ultrasonication. Composite films were prepared by mixing the dispersions with a segmented  polyurethane (SMPu) solution in MIBK, followed by casting and solvent evaporation. PANI-NC fibers  resulted more conductive than neat PANI ones and the same behavior was found for the resulting composite  films, being the last ones in the range of semi-conductive polymers. As the concentration of nanofibers  was maintained under 5 wt%, the thermal, mechanical and shape memory properties of the polyurethane  matrix were not negatively affected or even slightly improved with the addition of nanofibers. In particular,  the addition of any of the fibers led to an increase in the tensile modulus without decreasing  the elongation at break, while the use of PANI ones resulted in an increase of the recovery capacity  of the samples and the incorporation of PANI-NC fibers led to an increase in the recovery force. However,  the transparency of the neat SMPu was lost, since even the less concentrated composite films resulted  homogeneously green colored. On the other hand, no evidence of nanofiber percolation through the  matrix was found.","palabras_clave":"POLYANILINE|NANOCELLULOSE|COMPOSITES|SHAPE MEMORY POLYURETHANES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89433,"idioma_id":4,"titulo":"Moisture dependence of  the properties of composites made from tung oil based polyurethane and wood flour","resumen":"Natural composites prepared f rom a poly urethane (PU) based on tung oil  and dif f erent percentages of wood f lour (WF) or microcellulose (MC) were  exposed to humid env ironments and the resulting changes of their  properties were ev aluated. The equilibrium moisture content of the  composites increased with the wood f lour percentage. Dy namic mechanical  tests perf ormed during temperature scans rev ealed the changes resulting  f rom moisture absorption on the main transition temperature of the matrix  as well as on the storage modulus. The tensile mechanical properties of the  materials were also strongly af f ected by moisture. The dif f erent degree of  dispersion achiev ed during the incorporation of WF and MC into the matrix  was considered the main reason f or the dif f erent ef f ect of each f iller on  the thermal and mechanical properties of the resulting composites.","palabras_clave":"NATURAL FIBERS|COMPOSITES|MECHANICAL PROPERTIES|MOISTURE ABSORPTION|VEGETABLE OILS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89434,"idioma_id":4,"titulo":"An adaptive amplifier system for wireless sensor network applications","resumen":"This paper presents an adaptive amplifier that is part of a sensor node in a wireless sensor network. The system presents a target gain that has to be maintained without direct human intervention despite the presence of faults. In addition, its bandwidth must be as large as possible. The system is composed of a software-based built-in self-test scheme implemented in the node that checks all the available gains in the amplifiers, a reconfigurable amplifier, and a genetic algorithm (GA) for reconfiguring the node resources that runs on a host computer. We adopt a PSoC device from Cypress for the node implementation. The performance evaluation of the scheme presented is made by adopting four different types of fault models in the amplifier gains. The fault simulation results show that GA finds the target gain with low error, maintains the bandwidth above the minimum tolerable bandwidth, and presents a runtime lower than exhaustive search method.","palabras_clave":"adaptive hardware|test|genetic algorithms|wireless sensor networks"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89435,"idioma_id":4,"titulo":"Tomato quality during short-term storage assesed by colour and electronic nose.","resumen":"An assay based on an electronic olfactory system was set to evaluate tomato fruits by sensing the aromatic volatiles during post-harvest storage during 21 days at 19 ± 0.5 °C in darkness. Olfactory system measurements were coupled with colour values. Odour profile and senescence parameters were carried out at 7 days intervals. Discriminat function analyses applied to electronic nose data showed two components, accounting for 99.8% of the total variance. Separation achieved among all groups was observed. Fruit lost weight almost linearly with shelf life (p <0.001) presenting an averaged loss of 21% (r2=0.98) for over-expressed (Money Maker) lines\/plants, 13% (r2=0.97) for silenced (Money Maker) and 14 % (r2=0.98) for wild-type during 21 days of storage. Colour values L*, a* and b* data showed that colour properties changed during storage for all the lines considered.","palabras_clave":"TOMATOE|VOLATIL COMPOUNDS|MATURE|COLOUR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89436,"idioma_id":5,"titulo":"Efecto de la utilización de perros durante el arreo y de la maduración sobre parámetros físicos de carne bovina","resumen":"La utilización de perros para el arreo de bovinos es un generador de estrés que modifica ciertos indicadores fisiológicos y que podría afectar la calidad de la carne obtenida. Por otro lado, la maduración de la carne es una herramienta para mejorar determinadas características de la carne. En el presente trabajo se utilizaron 48 vaquillonas de biotipo británico (Angus, Hereford y sus cruzas) sobre las cuales se aplicó uno de tres tratamientos al momento del arreo (3,2 km) desde los corrales de engorde hasta el embarcadero: I) arreo calmo y al paso, sin la presencia de perros (C), 2) arreo con ladridos grabados reproducidos por altavoces (LG), y 3) arreo con la utilización de perros (P). Se midió la velocidad de desplazamiento para cada tratamiento y se tomaron muestras de sangre antes y después del arreo, sobre las cuales se midió concentración de cortisol, creatinina y proteínas plasmáticas totales. Luego del transporte y de una espera en frigorífico de 15 horas, los animales fueron faenados y se obtuvieron muestras del Longissimus dorsi. Estas muestras fueron envasadas al vacío y se aplicaron tres tiempos de maduración (2ºC): 4, 11 y 18 días. Cumplida la maduración, se evaluó: análisis del perfil de textura (TPA), fuerza de corte en la cizalla de Warner-Bratzler (WB), color de músculo y grasa, y capacidad de retención de agua (CRA). Tanto el tratamiento P como el LG aumentaron la velocidad de desplazamiento, los niveles de cortisol sérico y tendieron a aumentar los niveles de creatinina plasmática. Sin embargo, la presencia de perros o de ladridos grabados no afectó las características físicas de la carne. La maduración redujo la WB y aumentó la CRA, afectando también el color del músculo y la mayoría de los parámetros evaluados en el TPA. Los resultados obtenidos permiten concluir que, bajo las condiciones del presente ensayo, el uso de perros o de ladridos grabados durante el arreo generaría un efecto estresante sobre los bovinos sin afectar la calidad de la carne obtenida. La maduración modificó la mayoría de los parámetros físicos evaluados en el Longissimus dorsi.","palabras_clave":"CALIDAD DE CARNES|ESTRES|MADURACION|CORTISOL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89437,"idioma_id":5,"titulo":"Planificación regional: recuperación y desafíos para la agenda pública de Argentina","resumen":"Política pública y región son alocuciones centrales en el devenir de la planificación en Argentina. Sin embargo, resulta posible hallar que desde diversas visiones, incluso las favorables a una intervención estatal, se han desestimado aspectos ligados con el origen del capital así como las prácticas empresariales y sus objetivos respecto al entorno social y ambiental. Considerando lo anterior, se pretende comprender la relación entre modelo de desarrollo y política de regulación de mercados a partir de la promoción de actividades productivas. Se parte de la coyuntura argentina, evaluando fundamentalmente el lapso 2002-2009, aunque recurriendo a hitos anteriores. Una indagación como la propuesta posee el valor de exponer logros y desaciertos de la regulación pública, para profundizar aquello que propenda a una distribución más equitativa del excedente generado en diversas actividades, así como evidenciar mecanismos que favorecerían la reproducción de las desigualdades entre los actores que componen aquellas.","palabras_clave":"PLANIFICACIÓN REGIONAL|POLÍTICA PÚBLICA|ECONOMÍA REGIONAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89438,"idioma_id":4,"titulo":"Stress-Induced Sensitization To Cocaine: Actin Cytoskeleton Remodeling Within Mesocorticolimbic Nuclei","resumen":"This study investigated the consequence of repeated stress on actin cytoskeleton remodeling in the nucleus accumbens (NAc) and prefrontal cortex (Pfc), and the involvement of this remodeling in the expression of stress-induced motor cross-sensitization with cocaine. Wistar rats were restrained daily (2 h) for 7 days and, 3 weeks later, their NAc and Pfc were dissected 45 min after acute saline or cocaine (30 mg\/kg i.p.). F-actin, actin-binding proteins (ABP) and GluR1 were quantified by Western blotting, and dendritic spines and postsynaptic density (PSD) size measured by electron microscopy. In the NAc from the stress plus cocaine group we observed a decrease in the phosphorylation of two ABPs, cofilin and cortactin, and an increase in the PSD size and the surface expression of GluR1, consistent with a more highly branched actin cytoskeleton. The Pfc also showed evidence of increased actin polymerization after stress as an increase was observed in Arp2, and in the number of spines. Inhibiting actin cycling and polymerization with latrunculin A into the NAc, but not the Pfc, inhibited the expression of cross-sensitization to cocaine (15 mg\/kg i.p.) and restored the expression of GluR1 to control levels. This study shows that a history of repeated stress alters the ability of a subsequent cocaine injection to modulate dendritic spine morphology, actin dynamics and GluR1 expression in the NAc. Furthermore, by regulating GluR1 expression in the NAc, elevated actin cycling contributes to the expression of cross-sensitization between stress and cocaine, while stress-induced changes in the Pfc were not associated with cross-sensitization.&nbsp;","palabras_clave":"actin-binding proteins  |AMPA receptors|dendritic spines|F-actin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89439,"idioma_id":4,"titulo":"Water-based enhancement of the resonant photoacoustic signal from methane\u2013air samples excited at 3.3 &#956;m","resumen":"Photoacoustic spectroscopy is widely applied for  trace-gas detection because of its sensitivity and low detection  limit. In a previous work, where we studied the  potential application to methane monitoring under a resonant  excitation at 3.3 &#956;m, we showed that the signal from  methane\u2013nitrogen mixtures decreases with the addition of  oxygen. This effect is due to an energy exchange between  the &#957;4 asymmetric stretching mode of methane and the first  metastable level of oxygen. This process makes oxygen accumulate  energy, thus hindering the generation of the photoacoustic  signal. In this work, we study the possible addition  of water, as a good collisional partner of oxygen, in order  to obtain a greater sensitivity.We develop a model based  on rate equations and find good agreement between theory  and measurements. The experiment is carried out with  a novel cell of rectangular cross section and a Q factor of  165 ± 1. We find that 0.7 % water content is large enough  to obtain a signal as high as in the methane\u2013nitrogen case at  atmospheric pressure.","palabras_clave":"METHANE|WATER|PHOTOACOUSTIC|OPO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89440,"idioma_id":5,"titulo":"Respuesta a la desecación y a la temperatura de almacenamiento del germoplasma de Prosopis nigra (Grisebach) Hieron.  y Ziziphus mistol Griseb.","resumen":"temperaturas de almacenamiento, lo que constituye el objetivo de este trabajo. El contenido dehumedad de las semillas frescas se determinó en estufa a 103°C y pesando las muestras a intervalos regulares hasta peso constante. La tolerancia a la desecación y a las temperaturas de almacenamiento se evaluaron con 5 experimentos de germinación: semillas frescas (10-12%CH); 3-5% CH; y 3-5% CH almacenadas tres meses a 25, 5 y -20ºC, con dos tratamientos: control y escarificación. El CH fue del 11% en ambas especies. En P. nigra, el porcentaje de germinación de las semillas escarificadas fue mayor al 80% en todos los experimentos realizados, mientras que el poder germinativo de las semillas del control disminuyó con la desecación y el almacenamiento. La temperatura de almacenamiento no influyó en la cantidad de semillas germinadas. El porcentaje de germinación de los endocarpos frescos de Z. mistol fue bajo (&lt;35%), pero aumentó con la reducción del CH. En síntesis, P. nigra y Z. mistol son tolerantes a la desecación y al&nbsp; Almacenamiento en las temperaturas probadas, por lo que pueden considerarse como probablemente ortodoxas.","palabras_clave":"CONSERVACION|GERMOPLASMA|CONTENIDO DE HUMEDAD|GERMINACION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89441,"idioma_id":5,"titulo":"Modelado tridimensional para el análisis de tensiones termoel\u0013asticas en transistores de potencia sometidos a Quemado por Evento \u0013 Unico","resumen":"Los componentes electrónicos que forman parte de equipos y sistemas que funcionan en ambientes radioactivos o en entornos de partículas cargadas pueden resultar afectados por el fenómeno conocido como Quemado por Evento Único, (Single Event Burnout, SEB), el cual consiste en el desarrollode energía térmica en el dispositivo a partir de su interacción con un ión pesado. Este evento puede causar daño permanente y la salida de servicio del equipo en el que se encuentra el dispositivo por lo que investigaciones sobre SEB en dispositivos de potencia pueden conducir a diseños que permitan reducir la ocurrencia de fallas catastróficas y por lo tanto incrementar la supervivencia de sistemas críticos.El fenómeno SEB se observa luego de la interacción de un ión con un transistor MOS (Metal-Oxide Semiconductor) en estado bloqueado o de no conducción y a partir de la energía depositada por la partícula incidente. Esta produce la ionización de la zona alrededor del camino del ión y debido a la presencia de campos eléctricos, el flujo de electrones hacia la región drenador y de huecos hacia la región del surtidor. La corriente de huecos produce una caída de voltaje que polariza directamente la región-p y la región surtidor lo que produce el disparo de transistores bipolares parásitos presentes en la estructura MOS. Luego, la corriente se concentra en una pequeña región a lo largo de la trayectoria del ión, elevando notoriamente la temperatura por efecto Joule y llevando el dispositivo a la ruptura secundaria, produciéndose una corrida térmica. Este es el mecanismo de falla tradicionalmente postulado en trabajos previos. Sin embargo, estos autores han demostrado mediante el uso de modelos bidimensionales que las tensiones de origen termoelástico pueden alcanzar valores críticos y comprometer regiones de importancia del dispositivoelectrónico.El objetivo de este trabajo es profundizar el estudio del fenómeno termoelástico producto del SEB mediante un modelo 3D dependiente del tiempo que contemple condiciones más realistas para la localización de la región de generación y en las variaciones en las dimensiones de la misma. En el modelado propuesto se acopla unidireccionalmente el campo de temperaturas con el de desplazamientos a partir de la dependencia de las propiedades mecánicas con la temperatura. Este modelo permite conocer la evolución temporal del campo de desplazamiento y las componentes del tensor de tensiones. De esta forma se puede predecir si alguno de los materiales constituyentes puede resultar comprometido al superarse losvalores admisibles de acuerdo al criterio de falla aplicado.Dado que se estudian nuevas situaciones, únicamente posible en una geometría tridimensional, los resultados obtenidos con este nuevo modelo podrían causar alteraciones en las secuencias de eventos que se reportaron previamente.","palabras_clave":"Quemado por evento único|Método de Elementos Finitos|termoelasticidad| transistores de potencia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89442,"idioma_id":4,"titulo":"Combined Chemotherapy and ALA based Photodynamic Therapy in leukemic murine cells","resumen":"The effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR + ALA-PDT was used compared to DOX + ALA-PDT. Resistant cell lines LBR-D160 and LBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells.©","palabras_clave":"ALA therapy|photodinamic therapy|leukemic cells"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89443,"idioma_id":4,"titulo":"A low-cost configurability test strategy for an embedded analog circuit","resumen":"This paper proposes a self-test strategy, Analog Configurability Test (ACT), for an embedded analog configurable circuit (EACC) composed by operational amplifiers and interconnection resources that are present in the MSP430 microcontroller family from Texas Instruments®. The ACT strategy minimizes the cost in hardware overhead by employing only the hardware and software resources of the microcontroller.   Our test proposal consists in programming all EACC configurations and testing its functionality by measuring only a few key parameters. The processor executes an embedded test routine that sequentially programs the configurations, acquires data from an ADC channel and performs required calculations. The test strategy is experimentally evaluated using commercial hardware provided by the vendor. Our experimental results show very good repeatability, with errors below the expected.","palabras_clave":"Analog circuits|Analog self-test|Embedded analog circuit testing|Microcontroller test"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89444,"idioma_id":4,"titulo":"Synthesis, characterization and ab initio computations  on some phosphoric triamides","resumen":"New phosphoric triamides with general formula P(O)X3 where X= N-4-methylpiperazinyl (1),N-4-phenylpiperazinyl (2), N-4-ethoxycarbonyl piperazinyl (3), N-2-tetrahydrofurfuryl (4)were synthesized and characterized by 1H, 13C, 31P NMR, IR, Mass spectroscopy and elemental analysis. The molecular structure for compounds 1-4 were obtained by using quantumchemical calculations (HF and B3LYP methods with the 6-31+G** basis set). Moreover,optimized structures for previously reported 4-FC6H4C(O)NHP(O)X2 phosphoric triamides, X= pyrrolidin-1-yl (5), piperidin-1-yl (6) and hexamethyleneimin-1-yl (7) were obtained using the solid state structure (CIF files) as a starting point for the gas phase computation in which all independent molecules in structures 6 (seven structures) and 7 (two structures) were included. The computed results were in good agreement with the data obtained from the X-ray crystalstructures reported earlier. The nuclear quadrupole coupling constants (NQCCs or s) were calculated about 5.0 and 10.0 MHz for the 17O atoms of P=O and C=O bonds. For nitrogen atoms bonded to the phosphorus the NQCCs were found in the range between 4.0 and 5.5 MHz, whereas for compounds 4-7, the expected values for amidic hydrogen atoms are near 300 kHz.","palabras_clave":"phosphoric triamide|NMR|ab initio computations|NQR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89445,"idioma_id":4,"titulo":"Short periodic orbit approach to resonances and the fractal Weyl law","resumen":"We investigate the properties of the semiclassical short periodic orbit approach for the study of open quantum  maps that was recently introduced [Novaes, Pedrosa, Wisniacki, Carlo, and Keating, Phys. Rev. E 80, 035202(R)  (2009)]. We provide solid numerical evidence, for the paradigmatic systems of the open baker and cat maps, that  by using this approach the dimensionality of the eigenvalue problem is reduced according to the fractal Weyl law.  The method also reproduces the projectors |&#968;nR>< &#968;nL |, which involves the right and left states associated with a  given eigenvalue and is supported on the classical phase-space repeller.","palabras_clave":"OPEN|SYSTEMS|SCAR|FUNCTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89446,"idioma_id":4,"titulo":"Duality in reconstruction systems","resumen":"We consider reconstruction systems (RS´s), which are G-frames in a finite dimensional setting, and that includes the fusion frames as projective RS´s.    We describe the spectral picture of the set of RS operators for the projective systems with fixed weights.  We also introduce a functional defined on dual pairs of RS´s, called the joint potential, and study the structure of the minimizers of this functional. In the case of irreducible RS´s the minimizers are characterize as the tight systems. In the general case we give spectral and geometric characterizations of the minimizers of the joint potential. At the end of the paper we show several examples that illustrate our results.","palabras_clave":"Fusion frames|reconstruction systems|dual  reconstruction systems"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89447,"idioma_id":4,"titulo":"A new species of Acanthostigma (Tubeufiaceae, Dothideomycetes) from the Southern Hemisphere","resumen":"A new species belonging to the bitunicate ascomycetes genus Acanthostigma is described from bark of two Nothofagus species from Argentina. Its identity as a new species is confirmed based on both morphology and molecular sequence data. Acanthostigma patagonica differs from other species in the genus by having larger ascomata and setae and wider ascospores that are asymmetrical. An amended key to Acanthostigma species is provided along with a discussion of other species previously described from South America.","palabras_clave":"ITS|LSU|Nothofagus|phylogenetics|Southern Hemisphere|systematics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89448,"idioma_id":4,"titulo":"Rhynchomeliola Speg., an old genus new to Argentina","resumen":"During a survey of the micromycetes growing on native plants from the Patagonian Andean forests, two species of Rhynchomeliola Speg. were found: R. lomatiae S. Lee &amp; Joanne E. Taylor growing on leaves of Lomatia ferruginea (Proteaceae), and R. usteriana (Speg.) Arx &amp; Müller growing on bark of Nothofagus pumilio (Nothofagaceae). Rhynchomeliola is a small genus of long-necked, non stromatic, perithecial fungi which comprises nine species that are mostly tropical and foliicolous. In South America this genus was known only from Brazil. Rhynchomeliola lomatiae is recorded for the first time since its original description from herbarium material of Lomatia polymorpha in Australia. The finding of R. usteriana growing on bark is the first record of a Rhynchomeliola species on a lignified substrate and supports the rejection of the habit as a useful character to distinguish the genus from the morphologically akin Rhynchostoma P. Karst. Full descriptions and illustrations of the recorded species are provided along with those of the type materials of the species described by Spegazzini.","palabras_clave":"Ascomycota|Lomatia|Nothofagus|Perithecia"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89449,"idioma_id":4,"titulo":"Bubble columns dynamics inferred from the motion of a radioactive tracer followed by axially aligned detectors","resumen":"Bubble column dynamics can be properly studied with advanced velocimetry techniques, like radioactive particle tracking (RPT). However, sophisticated methods are scarcely used in the industrial environment; simpler methodologies like nuclear gauge scanning are generally preferred even if they provide more limited information. This work explores the feasibility of inferring information of the underlying dynamics in bubble columns, using a set of axially aligned detectors (AADs). The AADs scan simultaneously different column heights when a unique radioactive tracer is left free within the examined vessel, thus avoidingthe cumbersome calibration required for RPT. The combined response of the AADs is analyzed by means of a data mining procedure to determine quantitative indexes related to the underlying flow regime.","palabras_clave":"Axially Aligned Detectors|Radioactive tracers|Flow regimes|Bubble columns"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89450,"idioma_id":4,"titulo":"Blood pressure lowering effect of dietary (-)-epicatechin administration in L-NAME treated rats is associated with restoring nitric oxide levels","resumen":"Epidemiological and intervention studies have shown that the intake of   certain chocolates or cocoa products decreases blood pressure (BP) in   humans. (-)-Epicatechin is the most abundant flavanol present in cocoa   seeds and its derived foods. This work investigates the effects of   dietary (-)-epicatechin on BP in rats that received   N(&#969;)-nitro-l-arginine methyl ester (L-NAME) for 4 days. (-)-Epicatechin   administration prevented the 42mm Hg increase in BP associated with the   inhibition of NO production in a dose-dependent manner (0.2-4.0g\/kg   diet). This BP effect was associated with a reduction in L-NAME-mediated   increase in the indexes of oxidative stress (plasma TBARS and   GSSG\/GSH(2) ratio) and with a restoration of the NO concentration. At   the vascular level, none of the treatments modified NOS expression, but   (-)-epicatechin administration avoided the L-NAME-mediated decrease in   eNOS activity and increase in both superoxide anion production and NOX   subunit p47(phox) expression. In summary, (-)-epicatechin was able to   prevent the increase in BP and in oxidative stress and restored NO   bioavailability. The fact that (-)-epicatechin is present in several   plants usually consumed by humans gives the possibility of developing   diets rich in those plants or pharmacological strategies using that   flavonoid to diminish BP in hypertensive subjects.","palabras_clave":"blood pressure|epicathechin|nitric oxide|dietary"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89451,"idioma_id":4,"titulo":"An operative dengue risk stratification system in Argentina based on geospatial technology","resumen":"Based on an agreement between the Ministry of Health and the National Space Activities Commission in Argentina, an integrated informatics platform for dengue risk using geospatial technology for the surveillance and prediction of risk areas for dengue fever has been designed. The task was focused on developing stratification based on environmental (historical and current), viral, social and entomological situation for >3,000 cities as part of a system. The platform, developed with open-source software with pattern design, following the European Space Agency standards for space informatics, delivers two products: a national risk map consisting of point vectors for each city\/town\/locality and an approximate 50 m resolution urban risk map modelling the risk inside selected high-risk cities. The operative system, architecture and tools used in the development are described, including a detailed list of end users´ requirements. Additionally, an algorithm based on bibliography and landscape epidemiology concepts is presented and discussed. The system, in operation since September 2011, is capable of continuously improving the algorithms producing improved risk stratifications without a complete set of inputs. The platform was specifically developed for surveillance of dengue fever as this disease has reemerged in Argentina but the aim is to widen the scope to include also other relevant vector-borne diseases such as chagas, malaria and leishmaniasis as well as other countries belonging to south region of Latin America.","palabras_clave":"dengue|decision informatics support|geomatics|risk"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89452,"idioma_id":4,"titulo":"Summer-autumn distribution and abundance of the hantavirus host, Oligoryzomys longicaudatus, in Northwestern Chubut, Argentina","resumen":"We examined population density of Oligoryzomys longicaudatus (colilargo) and prevalence of Andes virus (ANDV) antibody at regional and landscape spatial scales in northwestern Chubut Province (Argentina) and contrasted it with climatic variables recorded by meteorologic stations near the study area. Mice were trapped in late summer\u2013early fall (March\u2013April) for 3 years (2007\u20132009). The composition of the rodent assemblage and species representation in the community varied among years, regions (forest, ecotone, and steppe), and landscape units (Nothofagus and Austrocedrus forests, sweet briar shrublands, and without sweet briar shrublands). Colilargos occurred in all regions and landscape units within the study area, from dense forest to open habitats such as steppe. The species dominated the rodent assemblages of ecotone and forest at a regional scale and the assemblages in sweet briar shrublands and Austrocedrus forests at a landscape scale. Abundance of colilargos also varied among periods, regions, and landscape units. Antibodies to ANDV were found in all regions but not in every landscape unit. Thus there is a potential for human hantavirus pulmonary syndrome (HPS) cases to occur not only in forests and shrublands, but also in steppe. At a landscape scale, Nothofagus forests appeared to pose a higher risk than Austrocedrus in wet years, because colilargo abundance and ANDV antibody prevalence were significantly greater. Within ecotone, sweet briar shrublands posed greater risk than habitats without sweet briar. Sweet briar shrublands were the landscape unit with the highest colilargo abundances during the driest periods. Sweet briar shrublands may play an important role in HPS dynamics, and should be considered when designing prevention policies.","palabras_clave":"ANDES VIRUS|ARGENTINA|HANTAVIRUS|OLIGORYZOMYS LONGICAUDATUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89453,"idioma_id":4,"titulo":"Characterization of the proteolytic system present in Vasconcellea quercifolia latex","resumen":"Vasconcellea quercifolia (Caricaceae) latex contains several cysteine endopeptidases with high proteolytic activity. Cysteine endopeptidases are the main active compounds used by the plant as a defense mechanism. A proteolytic preparation from V. quercifolia (??oak leaved papaya??) latex was purified by cation exchange chromatography. From SDS-PAGE and blotting of the selected fractions, the N-terminal amino acid sequences of polypeptides were determined by Edman?s degradation. The analysis by peptide mass fingerprinting (PMF) of the enzymes allowed their characterization and confirmed the presence of seven different cysteine proteinases in the latex of V. quercifolia. Moreover, the comparison between the tryptic maps with those deposited in databases using the MASCOT tool showed that none of the isolated proteases matched with another plant protease. Notably, a propeptidase was detected in the plant latex, which is being the first report in this sense. Furthermore, the cDNA of one of the cysteine proteases that is expressed in the latex of V. quercifolia was cloned and sequenced. The consensus sequence was aligned using the ClustalX web server, which allowed detecting a high degree of identity with cysteine proteases of the Caricaceae family and establishing the evolutionary relationship between them. We also observed a high conservation degree for those amino acid residues which are essential for the catalytic activity and tridimensional structure of the plant proteases belonging to the subfamily C1A. The PMF analysis strongly suggests that the sequence obtained corresponds to the VQ-III peptidase. ","palabras_clave":"Caricaceae|cDNA|cysteine endopeptidases|Peptide mass fingerprint |plant proteases|Vasconcellea"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89454,"idioma_id":4,"titulo":"Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc","resumen":"Cisplatin (Cs) is a chemotherapeutic agent able to generate reactive oxygen species (ROS) which are linked to several side effects of the drug. Even when it is known that Cs produces Leydig cell dysfunction, it is unknown whether this particular side effect is mediated by ROS. The aim of this study was to evaluate the in vitro effects of Cs on testosterone production and the participation of ROS in this effect. We demonstrate that Cs promotes the generation of ROS in a time-, and concentration-dependent fashion, not only in mouse testicular interstitial cells but also in MA-10 Leydig cells. Also, Cs inhibits testosterone synthesis in a concentration-dependent fashion (5-50 &#956;M for 4 h) and to a similar extent, in cells exposed to human chorionic gondadotropin hormone (hCG), to an analog of the second messenger cAMP (8Br-cAMP) or to a freely diffusible cholesterol analog (22R-hydroxycholesterol). However, this treatment does not inhibit the conversion of pregnenolone to testosterone. These data suggest that Cs exerts its inhibitory action on testosterone synthesis by an action at the level of P450scc. We also demonstrated that an antioxidant impairs the inhibitory effect of Cs on the conversion of the cholesterol analog into pregnenolone and that Cs does not change the expression level of P450scc mRNA. Therefore, it is concluded that Cs inhibits testosterone synthesis by a mechanism that includes the inhibition of P450scc by ROS.","palabras_clave":"Cisplatin|Leydig|ROS|Steroidogenesis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89455,"idioma_id":4,"titulo":"Efficient diborane-mediated synthesis of phthalocyanines carrying amino 3 groups near the macrocycle","resumen":"              Abstract:  N-(3,4-dicyanophenyl)piperidine-2,6-dione (2)  and 4-phthalimidoph-thalonitrile (3)&nbsp; were synthesized in 24% and 74% yield  respectively, using 4-aminophthalonitrile as the&nbsp; starting material. Treatment of 2 and 3 with zinc acetate in the presence of  1,8-diazabicyclo[5.4.0]undec-7-ene gave respectively phthalocyanines 4 and 5, whose reduction with diborane afforded dyes 6 and 7. Quaternization  of 6 and 7 with iodomethane gave cationic zinc(II) phthalocyanines 8 and 9 respectively. A bathochromic shift was observed in the  absorption spectra&nbsp; when amino and  ammonium groups were present near the macrocycle in comparison with those dyes  carrying alkylamino and quaternary alkyl ammonium salts &nbsp;as peripheral substituents.","palabras_clave":"ZINC(II)PHTHALOCYANINES|4-AMINOPHTHALONITRILE|REDUCTION|DIBORANE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89456,"idioma_id":4,"titulo":"Characterization of a multilayer film activated with Lactobacillus curvatus CRL705 bacteriocins","resumen":"BACKGROUND: Bacteriocins produced by lactic acid bacteria offer enormous promise for food safety preservation. In this study an active multilayer film obtained by the incorporation of lactocin 705 and lactocin AL705, two bacteriocins produced by Lactobacillus curvatus CRL705 with antimicrobial activity against Lactobacillus plantarum CRL691 and Listeria innocua 7, respectively, was characterized for its potential application in active packaging technology. Film activity performance at different storage conditions, bacteriocins transfer into water and sunflower oil, and film surface properties were evaluated.    RESULTS: Film activity against L. innocua 7 was maintained during 2, 4 and 6 weeks at 30, 10 and 5 °C respectively. At 30 and 10 °C, activity loss against L. plantarum CRL691 was observed on the second week of storage and after the fourth week at 5 °C. Results showed no significant difference for active multilayer film contact angle and seal properties compared to the control (without bacteriocins). A decrease in lactocin 705 inhibitory activity after sunflower oil contact was observed, while lactocin AL705 remained unaffected. After water contact, film activity was retained for both bacteriocins.    CONCLUSIONS: As demonstrated by antimicrobial activity and physico-mechanical properties retention, lactocin 705 and AL705 active multilayer film present potential for application in active packaging technology.","palabras_clave":"ACTIVE PACKAGING TECHNOLOGY|BACTERIOCINS|LISTERIA|MULTILAYER FILM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89457,"idioma_id":5,"titulo":"San José de Flores entre el Pacto y el bondi. Una arqueología de pueblo y ciudad","resumen":"RESUMEN  En este trabajo se plantea el desarrollo del otrora pueblo de San José de Flores en las afueras de Buenos Aires a fines de siglo XIX. En el desarrollo de las áreas periurbanas juegan un rol fundamental los nuevos medios de comunicación y transporte masivos: el telégrafo, el ferrocarril y el tranway hicieron su aparición a mediados del siglo XIX. La urbanización paulatina del paisaje rural implica la construcción de espacios públicos y la delimitación de los privados. El adoquinado y la iluminación de las vías de circulación tienen un papel esencial en ese proceso. Por otra parte, la integración al sistema urbano dinamiza las actividades comerciales, aumentando la apertura de locales y la variedad de productos consumidos por la población. Planteamos que para estudiar estos procesos es de utilidad una teoría que tenga en cuenta los cambios acontecidos con la revolución industrial a nivel global, creemos que ésta es la del Sistema Mundial.","palabras_clave":"Urbanismo|Arqueología|Consumo|Intregración|Sistema Mundial"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89458,"idioma_id":4,"titulo":"Crassoascus monocaudatus and Iodosphaeria podocarpi, two new species on Podocarpus parlatorei from ?Las Yungas?, Argentina","resumen":"During a biodiversity study of micromycetes occurring on bark and decorticated wood of a native gymnosperm, Podocarpus parlatorei Pilg., from Argentina, new taxa of Crassoascus and Iodosphaeria were found. They are described, illustrated and compared with the known species within each genus.","palabras_clave":"AMPHISPHARIACEAE|ASCOMYCOTA|IODOSPHARIACEAE|CLYPEOSPHARIACEAE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89459,"idioma_id":4,"titulo":"Bayesian conjugate analysis using a generalized inverted Wishart distribution accounts for differential uncertainty among the genetic parameters ? an application to the maternal animal model","resumen":"Consider the estimation of genetic (co)variance components from a maternal animal model (MAM) using a conjugated Bayesian approach. Usually, more uncertainty is expected a priori on the value of the maternal additive variance than on the value of the direct additive variance. However, it is not possible to model such differential uncertainty when assuming an inverted Wishart (IW) distribution for the genetic covariance matrix. Instead, consider the use of a generalized inverted Wishart (GIW) distribution. The GIW is essentially an extension of the IW distribution with a larger set of distinct parameters. In this study, the GIW distribution in its full generality is introduced and theoretical results regarding its use as the prior distribution for the genetic covariance matrix of the MAM are derived. In particular, we prove that the conditional conjugacy property holds so that parameter estimation can be accomplished via the Gibbs sampler. A sampling algorithm is also sketched. Furthermore, we describe how to specify the hyperparameters to account for differential prior opinion on the (co)variance components. A recursive strategy to elicit these parameters is then presented and tested using field records and simulated data. The procedure returned accurate estimates and reduced standard errors when compared with non-informative prior settings while improving the convergence rates. In general, faster convergence was always observed when a stronger weight was placed on the prior distributions. However, analyses based on the IW distribution have also produced biased estimates when the prior means were set to over-dispersed values.","palabras_clave":"Elicitation methods|Gibbs sampler|Prior distributions|Variance components estimation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89460,"idioma_id":4,"titulo":"The scenario of two-dimensional instabilities of the cylinder wake under electrohydrodynamic forcing: a linear stability analysis","resumen":"                                      We propose to study the stability properties of   an air flow wake forced by a dielectric barrier discharge (DBD)   actuator, which is a type of electrohydrodynamic (EHD) actuator. These   actuators add momentum to the flow around a cylinder in regions close to   the wall and, in our case, are symmetrically disposed near the boundary   layer separation point.        Since the forcing frequencies, typical of   DBD, are much higher than the natural shedding frequency of the flow,   we will be considering the forcing actuation as stationary.        In the   first part, the flow around a circular cylinder modified by EHD   actuators will be experimentally studied by means of particle image   velocimetry (PIV). In the second part, the EHD actuators have been   numerically implemented as a boundary condition on the cylinder surface.   Using this boundary condition, the computationally obtained base flow   is then compared with the experimental one in order to relate the   control parameters from both methodologies.        After validating the   obtained agreement, we study the Hopf bifurcation that appears once the   flow starts the vortex shedding through experimental and computational   approaches. For the base flow derived from experimentally obtained   snapshots, we monitor the evolution of the velocity amplitude   oscillations. As to the computationally obtained base flow, its   stability is analyzed by solving a global eigenvalue problem obtained   from the linearized Navier-Stokes equations. Finally, the critical   parameters obtained from both approaches are compared.                                                      ","palabras_clave":"hydrodynamical stability|electrohydrodynamic|wake flow"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89461,"idioma_id":4,"titulo":"Soybean seed lectin prevents the accumulation of S-adenosyl methionine synthetase and the S1 30S ribosomal protein in Bradyrhizobium japonicum under C and N starvation","resumen":"Soybean lectin (SBL) participates in recognition between Bradyrhizobium japonicum and soybean,although its role remains unknown. To search for changes in the proteome in response to SBL, B.japonicum USDA 110 was incubated for 12 h in a C- and N-free medium with or without SBL (10 &#956;gml-1), and the soluble protein profiles were compared. Two polypeptides, S-adenosyl-methioninesynthetase (MetK) and the 30S ribosomal protein S1 (RpsA), were found only in the fractions fromrhizobia incubated without SBL. Transcript levels of metK and rpsA were not correlated withpolypeptide levels, indicating that there was regulation at translation. In support of this proposal, the 5\u2019translation initiation region of rpsA mRNA contained folding elements as those involved in regulationof its translation in other species. Dissapearence of MetK and RpsA from the soluble protein fractionsof SBL-treated rhizobia suggests that SBL might have attenuated the nutritional stress response of B.japonicum.","palabras_clave":"LECTIN|SOYBEAN|PROTEOMICS|RPSA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89462,"idioma_id":4,"titulo":"Swarming motility in Bradyrhizobium japonicum","resumen":"Flagella-driven bacterial motility is an important trait  for colonization in natural environments. Bradyrhizobium  japonicum is a soil species that possesses two different flagella systems:  one subpolar and the other lateral, each one with a filament formed by a  different set of flagellins. While the synthesis of subpolar flagellins was  constitutive, translation of lateral flagellins was detected in rhizobia grown  with L-arabinose but not with D-mannitol as sole carbon-source, independently  of whether bacteria were in liquid or semisolid medium. We characterized  swarming of B. japonicum in semisolid  medium and found that this motility was faster with L-arabinose than with D-mannitol.  By using mutants with deletions in each flagellin set, we evaluated the contribution  of each flagella system to swarming in semisolid culture media, and in soil. Mutants  devoid of either of the flagella were affected in swarming in culture media, being  this impairment stronger for mutants without lateral flagellum. In sterile soil  at 100 % or 80 % field capacity, flagella-driven motility of mutants able to  swim but impaired in swarming was similar to wild-type, indicating that swimming  was the predominant movement here.          &nbsp;  Keywords: Bradyrhizobium;  swimming; swarming; flagella; soil; rhizosphere.","palabras_clave":"BRADYRHIZOBIUM|SWIMMING|SWARMING|FLAGELLUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89463,"idioma_id":4,"titulo":"Major Miocene exhumation by fault-propagation folding within a metamorphosed, early Paleozoic thrust belt: northwestern Argentina","resumen":"The central Andean retroarc thrust belt is characterized by a southward transition at ~22°S in structural style (thin-skinned in Bolivia, thick-skinned in Argentina) and apparent magnitude of Cenozoic shortening (>100 km more in the north). With the aim of evaluating the abruptness and cause of this transition, we conducted a geological and geohermochronological study of the Cachi Range (~24?25°S), which is a prominent topographic feature at this latitude. Our U-Pb detrital zircon results from the oldest exposed rocks (Puncoviscana Formation)constrain deposition to mainly Cambrian time, followed by major, Cambro-Ordovician shortening and ~484 Ma magmatism. Later, Cretaceous rift faults were locally inverted during Cenozoic shortening. Coupled with previous work, our new (U-Th)\/He zircon results require 8-10 km of Miocene exhumation that was likely associated with fault-propagation folding within  the Cachi Range. After Miocene shortening, displacement on sinistral strike-slip faults demonstrates a change in stress state to a non-vertically oriented. This change in stress state may result from an increase in gravitational potential energy in response to significant crustal thickening and\/or lithospheric root removal. Our finding of localized Cenozoic shortening in the Cachi Range increases the estimate of the local magnitude of shortening, but still suggests that significantly less shortening was accommodated south of the thin-skinned Bolivian fold-thrust belt. Our results also underscore the importance of the pre-existing stratigraphic and structural architecture in orogens in influencing the style of subsequent deformation.","palabras_clave":"Puna|Andean tectonic|South America|Cenozoic shortening"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89464,"idioma_id":4,"titulo":"Behavior Alignment and Control Flow Verification of Process and Service Choreographies","resumen":"&nbsp;The representation of process and service choreographies has been recognized as an important requirement in service-oriented methodologies. The guarantee of alignment between process and service choreographies and the veri&#64257;cation of the behavior of choreographies represent an important improvement for such methodologies, since they enable the automatic generation of choreography service speci&#64257;cations from well-de&#64257;ned choreography process models. To deal with these issues, we propose a transformation pattern that guarantees behavior alignment between process and service choreographies, and a veri&#64257;cation method for the control &#64258;ow of choreographies, which can be applied to any choreography language. These approaches make use of the Global Interaction Nets (GI-Nets) language to formalize the behavior of process and service choreographies. This formal representation can then be used to conclude on the behavioral aspects of choreographies. In addition, we present a tool for the modeling, automatic generation and veri&#64257;cation of GI-Nets, and apply the proposed approaches to the UP-ColBPIP and WS-CDL choreography languages.","palabras_clave":"Verification|Choreography|Web Service|Business Process"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89465,"idioma_id":5,"titulo":"Imágenes, abstracciones y recuerdos","resumen":"El artículo retoma críticamente la noción de lo público como espacio de encuentro de aquello que pensamos como ?común?. Propone hablar de espacios públicos, en plural, rescatando la construcción de hegemonías, los encuentros, desencuentros, las desigualdades y diferencias. El texto se convierte en una invitación al reconocimiento de las múltiples voces y narratividades que escapan de la institucionalidad moderna.Por último, se articula esta propuesta con el abordaje metodológico de la investigación.Palabras claveEspacios públicos - hegemonía - narrativas - metodología de la investigación","palabras_clave":"COMUNICACION|RADIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89466,"idioma_id":4,"titulo":"Modeling ammonia oxidation over a Pt (533) surface","resumen":"We present a new reaction model for ammonia oxidation on a Pt (533)   surface and perform numerical simulations using mean field equations.   Kinetic parameters were taken from experiments and Density Functional   Theory (DFT) calculations. The model is based on an oxygen-activated   ammonia decomposition and includes NHx (x = 0, 1, 2) intermediates.   Reaction rates and coverages obtained from calculations show   semiquantitative agreement with values from kinetic and in-situ XPS   measurements up to 0.1 mbar pressures. Pathways for ammonia oxidation   were analyzed by varying kinetic parameters in the model, which provides   new insights into the relative importance of different reaction steps.","palabras_clave":"Computer simulations| Models of surface kinetics|Catalysis|Surface chemical reaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89467,"idioma_id":4,"titulo":"Photolytic and Radiolytic Oxidation of Humic Acid","resumen":"The reactions of Br2.-), Br., HO. and N3.- with Aldrich humic  acid (AHA) were investigated. The Br &#8260; Br2.-) radicals were  obtained in flash-photolysis experiments (lambda exc = 266 nm) performed  with NaS2O8 solutions in the presence of bromide ions.  HO.and N3.- radicals were generated by pulse radiolysis of N2Osaturated  solutions. From the combination of a bilinear analysis  and computer simulations of the absorbance traces, it was  possible to obtain information on the rate constants for the  reactions of Br2Æ), BrÆ, HOÆ and N3Æ with AHA and on the  intermediate species involved in the mechanism. Evidence for the  participation of phenoxyl radicals (kmax = 410 nm) is given.","palabras_clave":"FLASH PHOTOLYSIS|PULSE RADIOLYSIS|HUMIC ACID|KINETIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89468,"idioma_id":4,"titulo":"HELICOBACTER PYLORI BIOFILM FORMATION AND GENE EXPRESSION ON ABIOTIC SURFACES USING A CYANOBACTERIAL EXTRACT","resumen":"The effects of a cyanobacterial extract (CE) on Helicobacter pylori biofilm formation onto hydrophobic and hydrophilic abiotic surfaces and the expression of luxS, flaA, omp18, lpxD and ureA genes associated to biofilm were studied. NCTC11638 reference strain and HP796, a resistant clinical isolate, were grown in Mueller-Hinton broth supplemented with 5% fetal calf serum (FCS) or 1% CE. The ability to form biofilm, viability, morphological changes and gene expression of adhered H. pylori cells were&nbsp; determined. The strains were able to form biofilm on both surfaces with the nutritional supplements analyzed. H. pylori conserved a&nbsp;&nbsp; characteristic bacillary morphology and viability with CE. Cells attachment was higher with CE than FCS regardless of strains and&nbsp; surfaces. The most remarkable increase in gene expression was observed with the omp18 gene using the CE supplement, indicating&nbsp; the important participation of outer membrane proteins in biofilm establishment. The clinical isolate showed similar and even greater&nbsp; gene expression than the reference strain. The results obtained indicated that the nutrients provided by CE favored biofilm formation&nbsp; with retained pathogenicity that under certain conditions can occur in natural aquatic environments.","palabras_clave":"HELICOBACTER|PYLORI|BIOFILM|CYANOBACTERIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89469,"idioma_id":4,"titulo":"Shape memory segmented polyurethanes: Dependence of behavior on nanocellulose addition and testing conditions","resumen":"The response of synthesized shape memory segmented polyurethanes (PUs) was affected by the addition of cellulose nanocrystals, as well as by the various conditions selected to carry out thermomechanical cyclic tests. The PUs were synthesized from an &#945;-hydro-&#969;-hydroxy-poly(ethylene oxide), tolylene-2,4-diisocyanate and 1,4-butanediol as chain extender. Nanocomposites were prepared by mixing a suspension of cellulose nanocrystals in N,N-dimethylformamide with the thermoplastic PU dissolved in the same organic solvent. The thermal properties of the neat PU and resulting composites were examined using differential scanning calorimetry. It was found that cellulose addition increases the PU soft segment melting and crystallization temperatures and the degree of crystallinity of this phase. Shape memory behavior was studied using cyclic thermal tensile tests. Both neat PU and composites exhibit shape memory properties, with fixity and recovery values that depend on heating temperature, imposed deformation, deformation rate and nanofiller addition. Copyright © 2011 Society of Chemical Industry","palabras_clave":"Shape memory|polyurethanes|nanocellulose"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89470,"idioma_id":5,"titulo":"La Universidad desde las Prácticas Docentes","resumen":"La cuestión de las prácticas docentes en la Universidad plantea eldesafío de pensarlas desde diferentes espacios entretejidos, complementarios,que permiten interrogarse sobre la vida cotidiana, tanto al interior de lasaulas como fuera de ellas; como un lugar complejo, heterogéneo y enriquecidopor las diferencias.Las buenas prácticas &nbsp;comoconcepto en cuestión, polisémico, provocativo y abierto a la pregunta, nosobliga ?a la vez? a pensarlas en sus aspectos más pragmáticos, en lascuestiones que impactan en los sujetos que transitan, que desean acceder oatravesar las barreras que les imponen algunos ámbitos universitarios. Nos centraremos aquí, por lo tanto, en los procesos académicos ligados alas buenas prácticas de enseñanza, sin olvidar ?por supuesto? que estasprácticas se encuentran enmarcadas, contextualizadas en una instituciónparticular, atravesada por innumerables componentes que las limitan o laspotencian. Focalizarnos sobre las prácticas de enseñanza es, también,comprender la fuerte responsabilidad social que tiene la Universidad y revisarel conjunto de decisiones que se toman al interior del aula, o pensando lo quesucede en ellas. ","palabras_clave":"ENSEÑANZA|UNIVERSIDAD|ACCESIBILIDAD ACADEMICA|BUENAS PRÁCTICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89471,"idioma_id":4,"titulo":"Smart and structural thermosets from cationic copolymerization of a vegetable oil","resumen":"ABSTRACT:&nbsp; Copolymers based on tung oil (TO) and presenting a very wide range of properties were obtained. Depending on the chemical composition, materials fitted for structural or functional applications were prepared.&nbsp; The use of divinylbenzene (DVB) as a comonomer in the cationic polymerization of the triglyceride allowed us to obtain polymers with a high thermal stability in an ample temperature range and with a room-temperature modulus close to 1 GPa for percentage of TO up to 40 wt%. Styrene as a partial replacement of DVB in a copolymer containing 50 wt% TO resulted in a material with shape memory behavior with switch temperatures in the range 25-40°C. The mechanical properties and shape-memory behavior of copolymers with different chemical compositions were analyzed. It was observed that an increase in the DVB content increased the glass-transition temperature and modulus, which was associated with an increase in the crosslinking density and the contribution of the rigid aromatic structure of the comonomer. &nbsp;&nbsp; Keywords: cationic polymerization; copolymers; mechanical properties; renewable resources.","palabras_clave":"CATIONIC POLYMERIZATION|COPOLYMERS|MECHANICAL PROPERTIES|RENEWABLE RESOURCES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89472,"idioma_id":4,"titulo":"Vegetable oil\/styrene thermoset copolymers with shape memory behavior and damping capacity","resumen":"The mechanical and damping properties, as well as the shape memory behavior of copolymers obtained by cationic copolymerization of tung oil with styrene with different stoichiometric ratios, are presented and analyzed in this work.&nbsp; The glass transition temperatures are close to room temperature for all the copolymers, and generally increase with the content of styrene. A similar trend is observed for the modulus, which exhibits values from 4.89 MPa for the copolymer with 30 wt% styrene to 13.92 MPa for the copolymer with 70 wt% styrene. These hard elastomers present shape memory behavior with high recovery and fixity ratios, as well as high damping quality (damping factors 0.4 and 1.38 at 28.9 and 43.3°C, for the tung oil homopolymer and the copolymer with 70wt% styrene, respectively), opening possibilities for practical applications that require material response close to room temperature.&nbsp; Keywords: vegetable oil; styrene; shape memory effect; damping properties; cationic copolymerization.","palabras_clave":"VEGETABLE OIL|STYRENE|SHAPE MEMORY BEHAVIOR|CATIONIC POLYMERIZATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89473,"idioma_id":4,"titulo":"The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells","resumen":"Aplidin is a novel cyclic depsipeptide, currently in Phase II\/III clinical trials for solid and hematologic malignancies. The aim of this study was to evaluate the effect of Aplidin in chronic lymphocytic leukemia (CLL), the most common leukemia in the adult. Although there have been considerable advances in the treatment of CLL over the last decade, drug resistance and immunosuppression limit the use of current therapy and warrant the development of novel agents. Here we report that Aplidin induced a dose- and time-dependent cytotoxicity on peripheral blood mononuclear cells (PBMC) from CLL patients. Interestingly, Aplidin effect was markedly higher on monocytes compared to T lymphocytes, NK cells or the malignant B-cell clone. Hence, we next evaluated Aplidin activity on nurse-like cells (NLC) which represent a cell subset differentiated from monocytes that favors leukemic cell progression through pro-survival signals. NLC were highly sensitive to Aplidin and, more importantly, their death indirectly decreased neoplasic clone viability. The mechanisms of Aplidin-induced cell death in monocytic cells involved activation of caspase-3 and subsequent PARP fragmentation, indicative of death via apoptosis. Aplidin also showed synergistic activity when combined with fludarabine or cyclophosphamide. Taken together, our results show that Aplidin affects the viability of leukemic cells in two different ways: inducing a direct effect on the malignant B-CLL clone; and indirectly, by modifying the microenvironment that allows tumor growth.","palabras_clave":"Aplidin|Tumor microenviorement|Chronic lymphocytic leukemia|monocytes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89474,"idioma_id":4,"titulo":"Bioindicators and biomarkers of environmental pollution in the middle-lower basin of the Suquía River (Córdoba, Argentina)","resumen":"The Suquía River middle-lower basin (Córdoba, Argentina) is subject to a strong anthropogenic impact because it receives pollutants from different sources. Recent studies have shown the importance and the need of approaching the monitoring process of water quality from integral perspectives, through the utilization of chemical as well as biological methods. The main goal of this study was to evaluate the fish species Jenynsia multidentata as a bioindicator of environmental pollution in the middle-lower basin of the Suquía River using biotransformation and antioxidant enzymes as well as gill and liver histopathology as biomarkers. We also studied the fish assemblage characteristics through the fish species pattern variation and the application of a Biotic Index based on fish data. Our study also included the analysis of a Water Quality Index (WQI), heavy metal concentrations in sediment and water and pesticide concentrations in sediment.&nbsp; The chemical analyses of the middle-lower Suquía river basin revealed a water quality degradation gradient. Fish assemblage structure changed with increasing water pollution, showing a simpler structure at the most polluted area. According to the Bioitc Index, the variation pattern of fish assemblages reflected the aquatic environment deterioration. Both molecular and histopathological biomarkers perceived the same trend in relation to water quality. However, enzymes discriminated with acuter precision between seasons. Besides, each enzyme presented different sensibility. At tissue level, the histopathological analysis detected chronic contamination at both stations and seasons. The present work that comprises different levels of biological organization together with chemical analyses generated particular although complementary information, evidencing the same trend of aquatic contamination. Thus, the development of integral investigations gives a comprehensive approach and becomes the most effective tool to construct policies both preventive and palliative. ","palabras_clave":"freshwater quality|fish assemblages|Jenynsia multidentata|gill and liver histopathology|antioxidant enzymes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89475,"idioma_id":4,"titulo":"Neuroendocrine system of the digestive tract in Rhamdia quelen juvenile: An immunohistochemical study","resumen":"In this work, an immunohistochemical study was performed to determine the distribution and relative frequencies of some neuromodulators of the digestive tract of silver catfish (Rhamdia quelen). The digestive tract of silver catfish was divided into six portions; the oesophagus, stomach, intestine (ascendant, descendant and convoluted segments), and rectum. Immunohistochemical method using a pool of specific antisera against-gastrin, -cholecystokinin-8, -leu-enkephalin, -neuropeptide Y, - calcitonin gene-related peptide (CGRP), and -vasoactive intestinal peptide (VIP) was employed. Immunoreactivity to all antisera  was identified in neuroendocrine cells (NECs) localized in the gut epithelium, although no reaction was observed in the oesophagus or stomach. The morphology of NECs immunopositive to each antibody was  similar. They were slender in shape, with basally located nucleus, and their main axis perpendicular to the basement membrane. The number of NECs immunoreactive to all antisera was higher in the ascendant  and descendant intestine, exhibiting a decreasing trend toward distal segments of the gut. In addition, immunoreactivity to CGRP and VIP was observed in the myenteric plexus and nerve fibers distributed  in the mucosal, submucosal and muscular layers. The higher number of immunopositive NECs in the ascendant and descendant intestine may indicate the primary role of these segments in the control of  food intake by means of orexigenic and anorexigenic peripheral signals.","palabras_clave":"NEUROENDOCRINE SYSTEM|GASTROINTESTINAL TRACT|NEUROMODULATORS|RHAMDIA QUELEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89476,"idioma_id":4,"titulo":"EFFECTS OF PREBIOTICS ON GROWTH AND SURVIVAL OF SILVER  CATFISH (Rhamdia quelen) JUVENILES","resumen":"Recently, proof of the advantages of employing beneficial microorganisms or organic additives as growth promoters, replacing chemoterapeutic and antimicrobial agents, has been obtained. The aim of this work was to evaluate the effect of two experimental diets, one supplemented by a flavonoid-based metabolic antioxidant (FLAVOXIN®) and the other supplemented by a combination of organic acids and yeast wall (UNIWALL   MOS 50®) on growth and survival parameters of  Rhamdia  quelen juveniles, in contrast to a control diet. The experiment consisted of three dietary treatments: a control consisting of a   commercial diet with 280g of proteins\/kg and 120g of lipids\/kg,   the commercial diet supplemented with FLAVOXIN® (FL) and commercial diet supplemented with UNIWALL MOS® (MOS), both products added on a 2g\/kg basis. Nine batches consisting of 42 specimens distributed in outdoor cement tanks of 16m3 were assigned according to a 3×3 Latin square design. The experiment lasted a total of 60 days. Weight gain was determined in all treatments, without statistical differences between them (p>0.05). The survival rate was 89% for the control diet and   97 and 95% for FL and MOS, respectively. Both FL and MOS treatments resulted superior and statistically different to the control diet (p<0.05). The results show that the use of FLAVOXIN® and UNIWALL MOS 50®   at the dose employed for this study has a positive effect on survival of  R. quelen juveniles, without modifying growth parameters.","palabras_clave":"DIETS|JUVENILES|PREBIOTICS|RHAMDIA QUELEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89477,"idioma_id":5,"titulo":"Desarrollo Ontogénico de la Columna Vertebral y del Esqueleto Caudal en Larvas de Rhamdia quelen en Condiciones de Larvicultura Intensiva","resumen":"Se analiza por primera vez el desarrollo osteologico de la columna vertebral y del esqueleto caudal en larvas de Rhamdia quelen mantenidas bajo condiciones controladas y con alimentacion artificial. Entre los d.as 1 a 20 posteriores a la eclosion (dpe) se muestrearon a intervalos regulares 400 larvas, que se colorearon y transparentaron siguiendo la tecnica de Taylor & Van Dike. En los primeros d.as de vida, las larvas presentan una notocorda recta en toda su longitud. El inicio de la formacion de la columna vertebral fue observado a los 7 dpe con la aparicion de las espinas neurales y hemales, y entre los 9 y 10 dpe para las tres primeras vertebras. La osificacion de la columna vertebral ocurrio en sentido craneo-caudal y fue completa a los 20 dpe. El esqueleto caudal inicia su desarrollo entre los 3 y 4 dpe, con la formacion de los hipurales (H), parahipural (PH) y los radios caudales. Los H 1 al 4 se formaron como primordios cartilaginosos en la cara ventral de la porcion distal de la notocorda, mientras que posteriormente lo hicieron el H 5 y el PH en el extremo distal y proximal del esqueleto caudal, respectivamente. El complejo centro ural (CCU) se osifico inicialmente en dos partes, una anterior que resulta de la combinacion del centro preural 1 y el ural 1 y una posterior con el ural 2. Los primeros radios de la aleta caudal aparecieron en larvas en flexion, mientras que despues de los 13 dpe, todos los ejemplares presentaron los radios principales osificados (ocho en la parte superior y ocho en la inferior). El desarrollo de la columna vertebral y del esqueleto caudal en R. quelen muestra patrones similares a los descriptos en otros peces teleosteos aunque con algunas particularidades que lo diferencian de los grupos relacionados.","palabras_clave":"LARVICULTURA INTENSIVA|RHAMDIA QUELEN|DESARROLLO OSTEOLOGICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89478,"idioma_id":4,"titulo":"Phylogeography and palaeodistribution modelling in the Patagonian steppe: the case of Mulinum spinosum (Apiaceae)","resumen":"Aim An integrative study of the endemic, yet ubiquitous Patagonian shrub Mulinum spinosum (Apiaceae) was performed to assess the historical processes that influenced its geographical pattern of genetic variation; to test the hypotheses of glacial refugia or in situ survival during glacial cycles; and to model extant and palaeoclimatic distributions to assess support for the phylogeographical patterns recovered. Location Chilean and Argentinean Andean region and Patagonian steppe. Methods Chloroplast DNA sequences, trnH?psbA, trnS?trnG and 3?trnV?ndhC, were obtained for 314 individuals from 71 populations. The haplotype data matrix was analysed using nested clade analysis (NCA) to construct a network. Analyses of molecular variance (AMOVA and SAMOVA) and neutrality tests were also used to test for genetic structure and range expansion. The present potential geographical distribution of Mulinum spinosum was modelled and projected onto a Last Glacial Maximum (LGM) model.2 Results Amongst the 29 haplotypes observed, one was widely distributed, but most were restricted to either northern or southern regions. The populations with highest haplotype diversity were found in southern Patagonia, the high Andean region, and northern Patagonia. AMOVA and SAMOVA showed latitudinal structure for Argentinean populations. NCA inferred patterns of restricted gene flow or dispersal but with some long distance dispersal and also long distance colonization and\/or past fragmentation. Neutrality tests did not support range expansions. The current distribution model was a fairly good representation of the extant geographical distribution of the species, and the distribution model for the LGM did not show important shifts of the extant range to lower latitudes, except for a shift towards the palaeo seashore. Main conclusions Based on agreement amongst phylogeographical patterns, distribution of genetic variability, equivocal evidence of putative refugia, and palaeodistribution modelling, it is probable that glaciations did not greatly impact the distribution of Mulinum spinosum. Our results are consistent with the in situ survival hypothesis, and not with the latitudinal migration of plant communities to avoid adverse climate conditions during Pleistocene glaciations. It is possible that populations of northern Patagonia may have been isolated from the southern ones by the Chubut and Deseado basins.","palabras_clave":"DISTRIBUTION MODELLING|NENEO|MULINUM SPINOSUM|PATAGONIAN STEPPE|PHYLOGEOGRAPHY|SOUTHERN SOUTH AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89479,"idioma_id":4,"titulo":"Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus","resumen":"Na-FAR-1 is an unusual &#945;-helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80&#8197;Å, &#945; = &#946; = &#947; = 90°) and diffracted to 2.5&#8197;Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38&#8197;Å, &#945; = &#946; = &#947; = 90°) and diffracted to 3.2&#8197;Å resolution. Crystal form 2 showed signs of significant twinning.","palabras_clave":"fatty acid and retinol binding protein|necator americanus|crystallographic structure"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89480,"idioma_id":4,"titulo":"MgH2 synthesis during reactive mechanical alloying studied by in-situ pressure monitoring","resumen":"The synthesis of MgH2 by reactive mechanicalmilling has been studied by monitoring H2 pressure changes inside amilling chamber. Mg and a Mg-10 wt.% C mixture were used as starting materialsand milled under 0.5 MPa of H2. The addition of C doubles the MgH2synthesis efficiency due to C acting as a process control agent. MgH2formation has been observed throughout milling and during the rest periodsbetween milling stages. Mg hydriding during the rest periods has been found tobe controlled by hydrogen diffusion through MgH2. High-diffusivitypaths along grain boundaries seem to be operative during the process. A lowerbound for the diffusion coefficient of H in MgH2 at room temperatureof 10-25 m2 s-1 has been estimated from thedata.","palabras_clave":"HYDROGEN DIFFUSION|MECHANICAL MILLING|MAGNESIUM HYDRIDE|SYNTHESIS|IN-SITU"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89481,"idioma_id":4,"titulo":"Effect of temperature, photoperiod, flooding, and drying on the hatching pattern of the eggs of Strelkovimermis spiculatus (Nematoda: Mermithidae)","resumen":"We assessed the number of Strelkovimermis spiculatus preparasites obtained from a known initial number of nematode eggs and the effect of  abiotic conditions (temperature, photoperiod, flooding?drying) on the number of emerged preparasites. Two egg groups were maintained: one continuously flooded, another with flooding?drying cycles (every 15, 30, 60 days). Each egg group was studied at 25 C and 14:10 (L:D) and 16 C and 12:12 (L:D). The flooded eggs contained a higher overall percentage of S. spiculatus preparasites compared to the wet?dry-cycle eggs. The Conditions of continuous flooding at 16 C and 12:12 (L:D) produced the maximum percent of emerged J2s (30 ± 15%). Preparasites were recorded by  7 (25 C) and 14 (16 C) days, suggesting this period as the minimum time for embryonic development.  The preparasite-emergence time observed from the same flooded-egg batch (98 and 112 days at 25 C  and 16 C, respectively) suggested a nonsynchronous hatching, possibly through nonuniform egg embryonation.  The time of exposure to drought in the assays did not significantly affect the total average percentage  of J2s obtained at 25 C and 14:10 (L:D), whereas at 16 C the number of emerged J2s diminished  with a prolongation of the drying period. The oviposition period was also recorded only at 16 C and  12:12 (L:D): S. spiculatus eggs were detected at 12.6 days after postparasite emergence, and oviposition  was complete at 51 days under those conditions. We propose a flooding schedule to optimize the  mass-rearing of S. spiculatus.","palabras_clave":"NEMATODEematode|CULICIDAE|ABIOTIC CONDITIONS|HATHING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89482,"idioma_id":4,"titulo":"Brucella spp. Lumazine Synthase as a novel immunomodulator to produce egg yolk antibodies","resumen":"Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein. It has been previously described as a carrier of peptides or proteins to increase their immunogenicity in different animal species, but its activity has never been evalu- ated in chickens. In this work, the use of BLS to im- prove the antibody response against bovine rotavirus (BRV) VP8d protein in laying hens was assessed. VP8d is the inner domain of the VP8 spike protein which preserves the sialic acid binding activity and the neutralizing epitopes present in the viral protein. Hens were immunized three times with 2 &#956;g of VP8d alone or fused to BLS. Hens inoculated with BLSVP8d developed higher antibody titers (evaluated by ELISA and viral neutralization test) than hens immunized either with VP8d alone or the mixture of VP8d and BLS. Furthermore, IgY antibodies against BLSVP8d were able to fully protect mice against challenge with virulent BRV in a dose-depent-manner. Overall, these results demonstrate that BLS is a potent immonumodulator that enhances the antibody response in hens, thus increasing the concentration of specific IgY in the egg yolk, one of the main issues to be adressed in order to improve the use of the IgY technology.","palabras_clave":"BLS|VP8|BOVINE ROTAVIRUS|IgY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89483,"idioma_id":4,"titulo":"Cluster automorphisms","resumen":"Abstract. We introduce a category of cluster algebras with &#64257;xed initial seeds. This categoryhas countable coproducts, which can be constructed combinatorially, but no products. We char-acterise isomorphisms and monomorphisms in this category and provide combinatorial methodsfor constructing special classes of monomorphisms and epimorphisms. In the case of clusteralgebras from surfaces, we describe interactions between this category and the geometry of thesurfaces.","palabras_clave":"Algebra Cluster"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89484,"idioma_id":5,"titulo":"CONDICIONES MEDIAS DE INVIERNO Y ONDAS CUASI-ESTACIONARIAS DE ROSSBY ASOCIADAS A LA FRECUENCIA INVERNAL DE NOCHES FRIAS Y CÁLIDAS EN ARGENTINA SUBTROPICAL","resumen":"El estudio busca definir las condiciones medias de la circulación troposférica y posibles forzantes asociados a la frecuencia de ocurrencia de noches frías (TN10) y noches calientes (TN90) durante el invierno austral (JJA) sobre Argentina subtropical, al norte de 40°S y adyacencias (ASA) a partir de datos de estaciones meteorológicas y de reanálisis (NCEP\/DOE AMIP-II  y ECMWF ERA-interim). Se encuentra que la frecuencia de ocurrencia de noches calientes (Tmin superiores al percentil 90, TN90) está modulada interanualmente por la propagación de ondas cuasi-estacionarias de Rossby inducidas por anomalías de convección en el Índico y el Pacífico. La mayor ocurrencia de noches calientes está asociado a calentamiento anómalo del Pacífico central ecuatorial (fase positiva del El Niño-Oscilación del Sur, ENSO). La menor frecuencia de ocurrencia de noches calientes está relacionada con convección anómala sobre el área monzónica de la India y el Índico sur tropical occidental. Esto favorece la propagación de actividad de ondas cuasi-estacionarias de Rossby sobre el Índico, el Pacífico y el sur de Sudamérica. Tal teleconexión a su vez favorece la mayor ocurrencia de noches frías. En cambio la menor ocurrencia de noches frías, está vinculados a variabilidad de baja frecuencia del modo de variabilidad de altas latitudes del hemisferio sur (el MAS). Los forzantes remotos encontrados involucran procesos atmosféricos\/oceánicos que se interconectan interestacionalmente lo cuál podría permitir desarrollar el pronóstico estadístico-dinámico estacional de la mayor o menor ocurrencia de noches frías o calientes en invierno.","palabras_clave":"extremos|temperatura mínima diaria|teleconexiones|ondas cuasi estacionarias de Rossby"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89485,"idioma_id":4,"titulo":"Friezes, strings and cluster variables","resumen":"-","palabras_clave":"Albragras Cluster"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89486,"idioma_id":4,"titulo":"Free nilpotent Lie algebras admitting ad-invariant metrics","resumen":"In this work we &#64257;nd necessary and su&#64259;cient conditions for a free nilpotent or a free metabelian nilpotent Lie algebra to be endowed with an ad-invariant metric. For such nilpotent Lie algebras admitting an ad-invariant metric the corresponding automorphisms groups are studied.","palabras_clave":"Free nilpotent Lie algebra| Free metabelian nilpotent Lie algebra |Ad-invariant metrics |Automorphisms and derivations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89487,"idioma_id":5,"titulo":"Influencia de la dieta sobre indicadores de calidad de carne de novillos con diferente composición de Bos taurus y Bos indicus","resumen":"El objetivo de este trabajo fue evaluar la incidencia del componente índico sobre la calidad de carne y su interacción con sistemas de alimentación de alta productividad. Se utilizaron cuatro proporciones de sangre índica: Hereford (0 % índico), Braford 1\/4, Braford 3\/8 y Braford 1\/2 sangre. Cada grupo fue sometido a tres dietas: pastoril exclusiva sobre una consociación de alfalfa y festuca (D1); igual base pastoril que D1 más suplementación con grano de maíz quebrado equivalente al 0,7% del peso vivo animal\/día  desde ingreso a terminación con interrupción entre noviembre y febrero (D2) y engorde a corral con grano de maíz quebrado, heno de alfalfa, expeller de soja y núcleo vitamínico mineral (D3). Se asignaron 10 animales por tratamiento que ingresaron con un peso promedio de 189,1 (±21,4) kg. Se faenaron conforme alcanzaban estado de terminación comercial determinado visualmente. De cada tratamiento se tomaron 6 novillos al azar de los que se obtuvieron muestras del músculo Longissimus dorsi entre 9º y 11º costilla anatómica a fin de analizar indicadores de calidad. Los pesos de faena fueron estadísticamente diferentes entre genotipos (p0,05). Salvo en AGPI el efecto de las dietas fue significativo (p<0,05). La alimentación a corral generó los menores niveles de CLA y las mayores relaciones omega-6\/omega-3 independientemente del tipo racial. Se detectó pérdida de terneza cuando el componente índico superó el 25%.","palabras_clave":"Bovinos|Bos taurus|Bos indicus|Calidad de carne"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89488,"idioma_id":4,"titulo":"Morphological and molecular identification of the fish-borne metacercaria of Ascocotyle (Phagicola) longa Ransom, 1920 in Mugil liza from Argentina","resumen":"This is the first report of Ascocotyle (Phagicola) longa Ransom, 1920 (Digenea: Heterophyidae)  in Argentina confirmed by morphological and molecular studies. The metacercaria was  found encysted in myotomal musculature, heart and mesentery of the mullet Mugil liza  (Pisces: Mugilidae) from Samborombon bay. We provide a morphological description of  the metacercaria which we identified using species-specific primers for A. (Phagicola) longa  and nucleotid sequence. This worldwide parasite has been reported as one of the causative  agents of heterophyiosis, an emerging fish-borne disease of humans, contracted by the  consumption of raw mullet. The discovery of A. (Phagicola) longa in Argentina represents a  warning of the potentially great impact of this parasite on public health.","palabras_clave":"ZOONOTIC DISEASE|MULLET|HETEROPHYIDAE|SAMBOROMBON BAY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89489,"idioma_id":4,"titulo":"Enteric infections by trematodes and nematodes in Olrog's Gull, Larus atlanticus","resumen":"Trematodes and nematodes can be pathogenic helminths of birds. Every year during the breeding season, there is variable mortality among chicks from the largest Olrog?s gull (Larus atlanticus) colony in Argentina. During two consecutive breeding seasons of Olrog?s gull, we studied epidemiological and pathological aspects of infections by digeneans (Microphallidae) and nematodes (Acuariidae) in Olrog?s gull chicks. Prevalence of nematode infection was 80.3% in 2005 and 89.2% in 2006, and  mean intensity was 23.7 in 2005 and 50.8 in 2006. The risk for infection rose 34.3% and the intensity of infection 6.7% for every increase of 1 mm in head?beak length. The nematodes occupied the proventricular glands and caused disruption of their structure and mild inflammatory proventriculitis. Prevalence of digenean infection was 97.0% in 2005 and 97.3% in 2006. In 10-day-old live chicks, prevalence was 98.0% in 2006 and 95.3% in 2007. Infection was associated with severe catarrhal enteritis, lymphocyte\/eosinophil-rich inflammatory responses, extensive fibroblast proliferation around the parasites, and disruption of the architecture of the adjacent crypts.","palabras_clave":"Helminth infections|Larus atlanticus|Olrog's Gull"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89490,"idioma_id":4,"titulo":"Parasitism (Trematoda, Digenea) in medusae from the  southwestern Atlantic Ocean: Medusa hosts, parasite prevalences, and ecological implications","resumen":"Digenean are important endoparasites of fish with complex life cycles; some genera include  medusae as secondary hosts. Their transmission to fish occurs when fish prey on these jelly hosts. Fish predation on jellyfish is a widespread phenomenon, even though predation by fish on jellyfish has not been determined through parasitism yet. We hypothesized  that medusae with high prevalences of digeneans could be important for their transmission to fish. A total of 48,900 specimens of 50 medusa species were analyzed; 2,181 harbored digeneans. Opechona sp. and Monascus filiformis were the most frequent and abundant parasites with the widest range of hosts. Hemiuridae gen. sp. and Bacciger sp. were found in few specimens of some medusa species. Prevalences  were unevenly distributed in the region. Three groups  with high prevalence values were identified mainly  related to frontal areas: Río de la Plata, Bahía Blanca, and North Patagonian tidal front. Eucheilota ventricularis, Clytia hemisphaerica, Proboscidactyla mutabilis, Liriope tetraphylla, and Aequoerea spp. were the medusae that contributed the most as secondary hosts to M. filiformis and Opechona sp. The high prevalences found in these medusae suggest that may be a fundamental part of the life cycles of both parasites in these areas.","palabras_clave":"MEDUSA|PARASITES|SOUTHATLANTIC|DIGENEA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89491,"idioma_id":4,"titulo":"The first record of a sauropod dinosaur from Antarctica","resumen":"Sauropoda is one of the most diverse and geographically widespread clades of herbivorous dinosaurs, and until now, their remains have nowbeen recovered from all continental landmasses except Antarctica. We report the first record of a sauropod dinosaur from Antarctica, represented by an incomplete caudal vertebra from the Late Cretaceous of James Ross Island. The size and morphology of the specimen allows its identification as a lithostrotian titanosaur. Our finding indicatesthat advanced titanosaurs achieved a global distribution at least by the Late Cretaceous.","palabras_clave":"ANTARCTIC PENINSULA|UPPER CRETACEOUS|TITANOSAURIA |LITHOSTROTIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89492,"idioma_id":4,"titulo":"Persistence of a Mesozoic, non-therian mammalian lineage (Gondwanatheria) in the mid-Paleogene of Patagonia","resumen":"We describe two isolated molariforms recovered from early\u2013middle Eocene (early Lutetian) levels of north- western Patagonia, Argentina. Comparisons with major lin- eages of therian and non-therian mammals lead us to refer them to a new genus and species of Gondwanatheria (Allo- theria). There is a single root supporting each tooth that is very short, wide, rounded, and covered by cementum; the steep sidewalls, lack of a neck between the crown and root, and the heavily worn stage in both molariforms suggest that they were of a protohypsodont type. Both teeth are strongly worn at their centers, all along their length, with the labial edge less worn than the lingual; they show strong transverse crests that alternate with lingual grooves. The protohypsodont aspect of the teeth, as well as the strong, transverse crests, are suggestive of sudamericid affinities; on the other hand, the thin enamel layer and the occlusal pattern formed by the crests and grooves shows more similarities to molariform teeth of the Ferugliotheriidae. The new taxon adds evidence regarding the (1) extensive radiation of the Gondwanatheria throughout the Southern Hemisphere, (2) persistence of several lineages well after the Cretaceous\/ Paleogene boundary, and (3) early evolution of hypsodont types among South American herbivorous mammals.","palabras_clave":"Gondwanatheria  |South America|Paleogene|hYPSODONCY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89493,"idioma_id":4,"titulo":"Weddellian marine\/coastal vertebrates diversity from a basal horizon (Ypresian, Eocene) of the Cucullaea I Allomember, La Meseta formation, Seymour (Marambio) Island, Antarctica","resumen":"Abstract: The La Meseta Formation crops out in Seymour\/Marambio Island, Weddell Sea, northeast of the Antarctic Peninsula  and  contains  one  of  the  world's  most  diverse  assemblages  of  Weddellian  marine\/coastal  verte-brates of Early Eocene (Ypresian) age. The La Meseta Formation is composed of poorly consolidated, marine sandstones and siltstones which were deposited in a coastal, deltaic and\/or estuarine environment. It includes marine invertebrates and vertebrates as well as terrestrial vertebrates and plants. The highly fossiliferous basal horizon (Cucullaea shell bed, Telm 4 of Sadler 1988) of the Cucullaea I Allomember is a laterally extensive shell bed with sandy matrix. The fish remains, including 35 species from 26 families, of the Ypresian Cucullaea bed represent one of the most abundant and diverse fossil vertebrate faunas yet recorded in southern latitudes. Stratigraphic distribution and phylogenetic relationships of the Weddellian sphenisciforms are consistent with a first radiation of this group in the Early Eocene. The first inquestionable archaeocete from Antarctica is recorded in this unit and is referred to a new taxon.","palabras_clave":"Antarctica|Marambio Island|Early Eocene|Vertebrates"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89494,"idioma_id":5,"titulo":"De la construcción del conocimiento científico a su enseñanza. Distintas explicaciones sobre la estructura del benceno","resumen":"Reviewing the historical development to represent a compound, in this case benzene, displays the different theories that struggled to give the best explanations, showing a dynamic vision for the scientific knowledge construction. The elemental composition and the establishment of the empirical formula, the recognition of isomers, the chemical reactivity, the availability of new technological devices and chemical bond theories (the structural theory, atomic theories, valence bond theory and molecular orbital theory) are the main factors that influenced knowledge about the structure of benzene. This work can be useful in teachers? training and perhaps enlightens on some students learning difficulties. This also is a useful model for future research that teachers can develop with their students including the meta-scientific knowledge actively in the classroom.","palabras_clave":"ESTRUCTURA DEL BENCENO|CONOCIMIENTO METACIENTÍFICO|QUÍMICA ORGÁNICA|ENSEÑANZA UNIVERSITARIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89495,"idioma_id":4,"titulo":"Difficulties of undergraduate students in the organic chemistry laboratory","resumen":"In order to study the learning difficulties of university students in the organic chemistry laboratory, a new Model for the Analysis of Experimental Work (MAEW) was developed. This article is organized into three parts: first, a historical look at the role of experimental work in science education, including the purpose of the laboratory class; next, a description of the MAEW; finally, we show how the MAEW can be applied to an actual laboratory class of organic chemistry. An original proposal for the classification of the materials used in an organic chemistry laboratory is also offered.","palabras_clave":"EXPERIMENTAL WORK|LEARNING DIFFICULTIES|ORGANIC CHEMISTRY LABORATORY|PROCEDURAL CONTENTS|UNIVERSITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89496,"idioma_id":4,"titulo":"A comparative study of two rear-arc plutons and implications for the Fuegian Andes tectonic evolution: Mount Kranck Pluton and Jeu-Jepén Monzonite, Argentina","resumen":"A petrologic, geochemical and geophysical study of two Late Cretaceous plutons of the Fuegian Andes iscarried out: the Jeu-Jepén Monzonite (JJM) and the Mt. Kranck Pluton (MKP). The plutons show a widelithological spectrum from ultramafic lithologies (clinopyroxenites and hornblendites), gabbros, dioritesto late stage K-feldspar syenite veins. They represent the top of magmatic chambers exposed at or closeto the roof level. Mode and chemistry indicate a monzonitic-mildly alkaline trend with high K2O content,equivalent to shoshonitic series. Trace element composition is typical of arc magmas. These features plustheir high LILE content (Ba 320e1600 ppm, Sr 475e1560 ppm), high LILE\/HFSE ratio (Rb\/Zr 0.6e1.6) andage confirm they belong to a rear-arc, monzonitic to mildly alkaline suite (the Fuegian Potassic Magmatism).Therefore, they represent the farthest-from-the-trench plutons in the suite. The petrographicaland chemical characteristics of the plutons suggest the lithological spectrum is the result of magmaticdifferentiation. The process involved crystal accumulation and magma mingling at the early stages,favored either by injections of fresh magma from deeper reservoirs and\/or the action of convectivecurrents within the chamber. Country rock assimilation also took part simultaneously with crystallization.The JJM and MKP lie along the trace of a Cenozoic left-lateral strike-slip fault (Magallanes-Fagnanofault system), on opposite blocks. However, lithological, chemical and geophysical subtle differencesbetween these two plutons suggest they evolved in individual magmatic chambers and therefore thedistance between them cannot be used as an estimation of total offset along the fault, as was indicated inprevious studie","palabras_clave":"MILDLY-ALKALINE PLUTONS|REAR-ARC MAGMATISM|CENOZOIC STRIKE-SLIP|FUEGIAN ANDES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89497,"idioma_id":4,"titulo":"Differences in yield physiology between modern, well adapted durum wheat cultivars grown under contrasting conditions","resumen":"not available","palabras_clave":"durum wheat|breeding|yield"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89498,"idioma_id":4,"titulo":"Selection for high grain number per unit stem length through four generations from mutants in a durum wheat population to increase yields of individual plants and crops","resumen":"In order to identify genotypes of durum wheat expressing improved yield and determining whether selection for individual plant efficiency in producing grains would improve plant and crop yield, we firstly compared the performance of segregating mutants and control cultivars and then selected divergent lines for number of grains per unit stem length, representing extreme source-sink balances further characterising the offspring lines. Research included three field experiments with individual segregating plants within the semi-arid region of the Ebro Valley during the 2006\/07, 07\/08 and 08\/09 growing seasons; a fourth experiment with segregating plants conducted under controlled conditions at Rothamsted in 2008\/09 and finally a conventional field plot experiment with the most promising lines derived from the selection. In the initial characterization of the selected mutants, there was a clear response to the selection made in M2, and differences in plant yield were due to differences in grains per plant and biomass. There was a clear response to selection for sink-strength in improving the number of grains exhibited by the offspring lines through the generations (M2\u2013M5) and the overall differences between the two divergent groups were consistently clear throughout the whole process. Response to selection was similarly expressed in field and in controlled conditions, implying high broad sense heritability of grains per plant (when there were no consistent differences in height and then it reflects grains per unit stem length). The best selections outyielded plants of the controls, without reducing the protein concentration of the grains. It seems clear that increasing the efficiency of conversion of growth during stem elongation into grains may be a relevant trait to further raise yield and that the trait used in the present study as a proxy of such efficiency (the number of grains per unit stem length) seemed appropriate as a selection criteria in early generations as it expressed similarly in isolated plants and in crop stands.","palabras_clave":"durum wheat|breeding|yield"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89499,"idioma_id":4,"titulo":"Nitrogen and water use efficiencies of wheat and barley under a Mediterranean environment in Catalonia","resumen":"no available","palabras_clave":"nitrogen use efficiency|water use efficiency |Triticum aestivum|Hordeum vulgare"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89500,"idioma_id":4,"titulo":"Environmental modulation of yield components in cereals: heritabilities reveal a hierarchy of phenotypic plasticities","resumen":"Yield components are relatively easy to measure and their interpretation is intuitive. However, strong environmental influences, genetic and physiological controls, and evolutionary constraints collectively lead to lack of independence among yield components that restrict their value in breeding and agronomic applications.Here, we first sketch a framework of plant responses to environmental factors to highlight the modulation of yield components by resources and their interplay with non-resource factors including developmental cues (e.g. maternal effects), extreme events (e.g. frost), predicting factors (e.g. photoperiod) and synchronising and integrating information (e.g. spectral composition of light). We suggest that, to the extent that non-resource cues allow plants to predict future availability of resources, simple resource-based models may be sufficient to capture the macroscopic responses of yield components to the environment.Next, we expand the original concept of hierarchy of plasticities between grain size (a relatively stable trait) and grain number (a plastic trait) to test the hypothesis of a broader hierarchy in the plasticities of yield components. Using published data for wheat, rice, barley and triticale, we verified that heritabilities capture the established hierarchy between plasticity of grain size and number. Median heritabilities of 0.31 for tiller number, 0.58 for inflorescence number, 0.59 for grains per inflorescence, and 0.79 for grain size supported the hierarchy of plasticities: tiller number > inflorescence number &#8776; grains per inflorescence > seed size. The heritability of grain yield was consistently higher than the heritability for tillering, consistently lower than the heritability for grain size, and suggestively close to the heritability of inflorescence number and grains per inflorescence, the components of grain number per unit ground area. We conclude that understanding the environmental regulation of yield components in cereals would benefit from a dual focus on yield-related traits per se and their plasticity.","palabras_clave":"yield components|cereals|breeding"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89501,"idioma_id":5,"titulo":"Aditivo orgánico en raciones para pacú (Piaractus mesopotamicus) en periodo reproductivo. Efecto sobre la recuperación de lesiones.","resumen":"El objetivo del presente trabajo  fue evaluar la recuperación de lesiones en reproductores de pacú (Piaractus mesopotamicus)  utilizando un reparador metabólico a base de flavonoides ofrecido antes o después de las  maniobras reproductivas (inducción y desove) en el alimento. Se utilizaron 39 ejemplares de  pacú, los que se distribuyeron aleatoriamente en tres grupos según el tipo de alimento ofrecido:  (G1) ración comercial; (G2) ración comercial hasta las maniobras reproductivas donde  cambia a ración comercial adicionada con 2 g\/kg de Flavoxin®; y (G3) ración comercial adicionada  con 2 g\/kg de Flavoxin® durante todo el período experimental. El ensayo tuvo una  duración de 69 días, período en el cual se realizaron biopsias ováricas como seguimiento de  la maduración gonadal. Durante el período previo a la hipofisación y desove o espermiación,  los reproductores mostraron buen estado general. Por el contrario, e inmediatamente posterior  a las maniobras reproductivas, se observó un alto número de lesiones en tegumento y aletas  en todos los ejemplares correspondientes al G1 y G2, destacándose el reducido número de  lesiones en G3, el cual se diferenció estadísticamente (p<0,05). En G3 no se observaron lesiones  posteriormente a los 9 días de las maniobras reproductivas, mientras que en G1 y G2  las mismas aún se encontraron presentes al final de la experiencia. Asimismo, al finalizar la  experiencia el porcentaje de supervivencia del G2 fue el más bajo (60%), diferenciándose  de G1 y G3 (p<0,05). Estos resultados demuestran que la utilización de 2 g\/kg de Flavoxin®  adicionado a raciones para reproductores de P. mesopotamicus, previamente a la realización  de las maniobras reproductivas, permite una pronta recuperación de las lesiones post-desove  o espermiación, mejorando el estado sanitario de los mismos.","palabras_clave":"PREBIOTICOS|REPRODUCCION|FLAVONOIDES|PIARACTUS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89502,"idioma_id":4,"titulo":"Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk","resumen":"Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by depurinating an adenine on the sarcin\u2013ricin loop (SRL) of the large subunit ribosomal RNA. Several RIPs interact with the C-terminal end of ribosomal stalk P proteins, and this interaction is required for their full activity. In contrast, the activity of Pokeweed Antiviral Protein is not affected by blocking this stalk component. Here, we provide evidence from phylogenetic analyses and sequence alignments suggesting that the interaction with the C-terminal end of P proteins evolved independently in different RIPs by convergent evolution.","palabras_clave":"Ribosome inactivating protein|Stalk|Phylogeny"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89503,"idioma_id":5,"titulo":"Una mirada sobre el estado actual  de la conservación de la flora argentina","resumen":"Argentina alberga 9.938 especies de plantas vasculares agrupadas en 2.000 géneros y 274 familias. Del total de especies presentes en el país, 1.760 son endémicas y 929 introducidas. La mayor riqueza específica se concentra en las provincias políticas del extremo noroeste argentino (Salta con 3.432 especies y Jujuy con 3.045), y del noreste, Misiones (3.166). Las familias botánicas con mayor número de especies son Asteraceae (1.498 especies, 394 endémicas), Poaceae (1.204 especies, 202 endémicas) y Fabaceae (737 especies, 162 endémicas). Estas áreas de mayor riqueza coinciden con la presencia de selvas subtropicales (Selvas de montaña o Yungas, en Salta y Jujuy) y selvas tropicales de llanura (Selva Paranaense, en Misiones). Argentina cuenta con una buena tradición botánica y hay numerosas instituciones de investigación botánica de alto nivel en el país. Pese a ello, los centros de investigación relacionados con la biología vegetal no han desarrollado aún programas destinados a solucionar problemas concretos de conservación. A pesar de las dificultades y desarrollo tardío de proyectos y programas de conservación de la diversidad vegetal en Argentina el futuro es promisorio o debiera serlo. Esta mirada se basa en los logros actuales relacionados con esta temática: la organización ininterrumpida desde su inicio del Congreso Nacional de Conservación de la Biodiversidad (Buenos Aires 2006, 2008, Tucumán 2010); la organización de entidades nacionales con planes de acción que involucran la conservación de la diversidad vegetal argentina (por ejemplo, la Red Argentina de Jardines Botánicos), la existencia de proyectos vinculados con la temática (Programa Nacional de Gestión de la Flora, proyecto PlanEAr, etc.), la generación de leyes nacionales como la Ley de Bosques, en desarrollo actual en el país, la concreción del Catálogo de las Plantas Vasculares del Cono Sur (2008), entre otros. Por supuesto, quedan cuestiones pendientes y aún puntos débiles como la articulación de los proyectos nacionales con los regionales, provinciales y locales, la mayor participación de los diferentes actores involucrados en esta problemática como las universidades, los centros científicos y organismos gubernamentales y no gubernamentales, así como un&nbsp; compromiso de toda sociedad con la conservación de la biodiversidad.","palabras_clave":"ARGENTINA|BIODIVERSIDAD|CONSERVACION|FLORA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89504,"idioma_id":4,"titulo":"The evolution of a highly speciose group in a changing environment: are we witnessing speciation in the Ibera wetlands?.","resumen":"Delimiting species is very conflicting in the case of very young taxa that are in theprocess of diversification, and even more difficult if the species inhabit a heterogeneousenvironment. In this case, even population delimitation is controversial. The SouthAmerican genus of subterranean rodents Ctenomys is highly speciose, with 62 speciesthat appeared in the lapse of 3 Myr. Within the genus, the \u2018perrensi\u2019 group, formed bythree named species and a group of forms of unknown taxonomic status, inhabits theIbera´ wetland, in northern Argentina. Almost every locality shows a particularchromosomal complement. To understand the relationships and the evolutionary processamong species and populations, we examined mitochondrial DNA sequences andmicrosatellite genotypes. We found an isolation-by-distance pattern with evidence ofcluster-like behaviour of the system. The mitochondrial DNA network revealed twodifferent groups, separated by one of the main rivers of the region. Clustering methodsdelimited 12 different populations and five metapopulation lineages that seem to beevolving independently. We found evidence of ancient migration among localities at thecentre of the distribution but no signals of current migration among the 12 delimitedclusters. Some of the genetic clusters found included localities with different chromosomalnumbers, which points to the existence of gene flow despite chromosomalvariation. The evolutionary future of these five lineages is controlled by the dynamics oftheir habitat: if stable, they may become distinct species; otherwise, they may collapseinto a hybrid swarm, forming a single evolving metapopulation. ","palabras_clave":"Ctenomys|habitat fragmentation|metapopulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89505,"idioma_id":5,"titulo":"Hacia una socio-historia del gabinete nacional","resumen":"Ubicado en la intersección entre la política y la administración, el Gabinete Nacional es una de las instituciones nucleares de la Presidencia, y las elites ministeriales, actores claves en la conformación de coaliciones de gobierno, en la formulación de las políticas públicas y en los procesos de legitimación de la autoridad estatal. No obstante esta importancia, en la Argentina no abundan estudios que se ocupen de reconstruir la historia, las prerrogativas, la dinámica y lovínculos dentro y entre estas carteras. Más allá del análisis específico de algunos ministerios o altos funcionarios de renombre,ni las distintas áreas que lo han compuesto, ni el lugar que les ha cabido en el gobierno y la gestión pública, ni las propiedades y acciones de sus ocupantes en el tiempo han merecido mayor atención. Centrado en la etapa que va desde la inflexión autoritaria de 1976 hasta la actualidad, este dossier propone un conjunto de líneas de investigación e hipótesis orientadas a reflexionar sobre este espacio central de la vida pública y política nacional.","palabras_clave":"GABINETE NACIONAL|ELITES MINISTERIALES|MINISTERIOS|SOCIO-HISTORIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89506,"idioma_id":4,"titulo":"Analysis of structural rehabilitation of historical masonry with reinforced concrete","resumen":"This school is declared in the heritage of Mendoza, Argentina. The masonry structure is fired bricks, without columns or braces. During its lifetime, it has suffered considerable damages due to local earthquakes and lack of maintenance. The study methodology used has included: a detailed study, emergency decisions, analysis of the conditions, diagnosis and rehabilitation proposals. In high seismic risk zone, it is difficult to strictly follow the principles of different letters of restoration and the task is a challenge for structural engineering. The use of concrete or steel, the costs and availability of local technology are analyzed by finite elements models. The advantage of using concrete in their rehabilitation is to achieve the lowest cost and structural performance in accordance to standards, but from the standpoint of heritage we prefer the combination of steel structures that do not interfere with original structure and with the rehabilitation of reinforced concrete foundation","palabras_clave":"masonry|rehabilitation|seismic capacity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89507,"idioma_id":4,"titulo":"First-order phase transitions in repulsive rigid k-mers on two-dimensional lattices","resumen":"In a previous paper [F. Romá, A. J. Ramirez-Pastor, and J. L. Riccardo, Phys. Rev. B 72, 035444 (2005)], the critical behavior of repulsive rigid rods of length k (k-mers) on a square lattice at half coverage has been studied by using Monte Carlo (MC) simulations. The obtained results indicated that (1) the phase transition occurring in the system is a second-order phase transition for all adsorbate sizes k; and (2) the universality class of the transition changes from 2D Ising-type for monomers (k = 1) to an unknown universality class for k &#8805; 2. In the present work, we revisit our previous results together with further numerical evidences, resulting from new extensive MC simulations based on an efficient exchange algorithm and using high-performance computational capabilities. In contrast to our previous conclusions (1) and (2), the new numerical calculations clearly support the occurrence of a first-order phase transition for k &#8805; 2. In addition, a similar scenario was found for k-mers adsorbed on the triangular lattice at coverage k\/(2k+1).","palabras_clave":"ADSORBED LAYERS|CRITICAL EXPONENTS|MONTE CARLO METHODS|PHASE TRANSITIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89508,"idioma_id":4,"titulo":"The higher relation bimodule","resumen":"Given a finite dimensional algebra $A$ of finite global dimension,  we consider the trivial extension of $A$ by the $A-A$-bimodule  $oplus_{ige 2} Ext^i_A(DA,A)$, which we call the higher relation  bimodule. We first give a recipe allowing to construct the quiver of  this trivial extension in case $A$ is a string algebra and then  apply it to prove that, if $A$ is gentle, then the tensor algebra of  the higher relation bimodule is gentle.","palabras_clave":"representation algebras|relation extension"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89509,"idioma_id":5,"titulo":"Lista de los peces de la Provincia de Catamarca","resumen":"Los censos de la fauna de un país o región cualquiera, constituyen  una suerte de codificación de la Naturaleza, como paso previo e  indispensable para un ensayo racional de aprovechamiento de las  riquezas naturales y de su adecuada conservación. Desde fines del  siglo XVIII se ha dicho, y lo han repetido en nuestro medio, Cosme  Argerich, Alberto Palcos y otros estudiosos y cientistas, que un  Código de la Naturaleza es indispensable para la libertad de una  nación. [R. A. Ringuelet & R. H. Arámburu. Enumeración  sistemática de los vertebrados de la Provincia de Buenos Aires. La  Plata, MAA, Publ. 119, 1957].","palabras_clave":"Ictiofauna|Catamarca|Lista"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89510,"idioma_id":5,"titulo":"El uso de los gestos en el discurso docente durante la planificación del juego en el jardín de infantes","resumen":"Desde la teoría sociocultural del desarrollo humano (Vigotsky, 2009; Bruner, 1986) se concibe a la interacción situada como el espacio privilegiado para el desarrollo del lenguaje. Dado que en ella las formas lingüísticas están imbricadas con otros sistemas semióticos, en el trabajo se analiza el uso de los gestos de la maestra en la planificación del juego en la sala de jardín de infantes de niños de 4 años. El análisis sigue una lógica cualitativa que articula el método Comparativo Constante (Strauss y Corbin, 1991) con el empleo heurístico de conceptos del Análisis de la Conversación (Goodwin 2000; Tusón, 1995) el microanálisis discursivo (Gumperz, 1982) y teorías de los gestos (McNeil, 1985, 1992). Se ha encontrado que los gestos señalan los aspectos centrales de la consigna y podrían, en ese sentido, favorecer la comprensión de los niños de referentes abstractos, vocabulario y las reglas.","palabras_clave":"GESTO|PLANIFICACIÓN |JUEGO|DISCURSO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89511,"idioma_id":5,"titulo":"Compartir cuentos en el hogar. Diferentes estilos de lectura en poblaciones urbano marginadas de Argentina","resumen":"Este artículo presenta un análisis de situaciones de lectura de cuentos -generadas a partir de un programa de alfabetización familiar- en las que participaron en el hogar, niños de poblaciones marginadas de Argentina. A diferencia de la mayoría de los estudios previos, se tomó como unidad de análisis a la situación tal como naturalmente se producía en los hogares, considerando a todos los participantes sin restringir el foco a la interacción diádica madre-niño. Los resultados mostraron que estas situaciones se diferencian entre sí en función de dos dimensiones: el grado en el que el cuento leído reproduce literalmente al texto escrito y el grado en la que la lectura se configura de modo colaborativo en la participación del pequeño. Estas dimensiones definen tres estilos de lectura: 1) Lectura literal del texto en una situación no compartida o limitadamente compartida; 2) Lectura que se distancia de la versión original del texto escrito, en forma lingüística y\/o por elaboración del contenido, en una situación muy compartida o limitadamente compartida y 3) Secuencias de preguntas del adulto y respuestas del niño que no configuran un relato del cuento. Los resultados aportan una visión no monolítica y uniforme de las características de la interacción durante la lectura de cuentos en hogares de niños de nivel socioeconómico bajo.","palabras_clave":"ALFABETIZACIÓN TEMPRANA|LECTURAS DE CUENTOS|INTERACCIÓN|HOGAR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89512,"idioma_id":5,"titulo":"Redes de colaboración en situaciones de alfabetización familiar con niños pequeños. Un estudio en poblaciones urbano marginadas de Argentina","resumen":"En el presente trabajo se analizan cualitativamente (Glasser y Strauss, 1967) las características particulares que adoptan las situaciones de alfabetización familiar en las que participaron 30 niños de 4 años de barrios urbano marginados de Argentina. Se atiende específicamente a la estructura de relaciones y de mediaciones sociales que durante la consecución de las situaciones configuran oportunidades para la participación del niño pequeño. El corpus está conformado por 124 situaciones de alfabetización registradas por medio de audio, generadas cuasiexprimentalmente a partir de la implementación de un programa de alfabetización temprana y familiar. Los resultados mostraron que en estos hogares en los que el bajo nivel de escolaridad de los adultos podía inhibir la consecución de la actividad de alfabetización, la composición extendida de las familias y la participación de los niños en amplias redes sociales facilita la realización de las actividades. En efecto, se observó que las situaciones de alfabetización se desarrollan en el marco de la interacción entre el niño y múltiples y diversos participantes que conforman distintas redes de colaboración en las que los niños pequeños, los niños mayores y los adultos desempeñan distintos roles. Estos resultados tienen fuertes implicancias pedagógicas, en tanto advierten sobre la importancia de entrelazar toda intervención educativa en los primeros años con los conocimientos y los patrones de interacción que caracterizan a la cultura de los niños, tanto en el contexto escolar de la educación inicial como en el familiar.   Publicación indexada es: IP & Sciences de Thomson Reuters, Psychological Abstracts, PsycINFO y PsycLit (APA), SciELO, RedALyC, Latindex, Fuente Académica de EBSCO, Informe Académico y Academic OneFile de Gale Cengage Learning, Scopus (ELSEVIER), Dialnet, DOAJ, Servicio de Información Bibliográfica (Bibliographical Information Service), BVS - PEPSIC - LILACS - BVS Psi Argentina, PSERINFO (psicologiacientífica.com),  PSICODOC, Red de Editores de Revistas Científicas en Psicología de Argentina.","palabras_clave":"ALFABETIZACIÓN TEMPRANA|ALFABETIZACIÓN FAMILIAR|INTERACCIÓN|REDES DE COLABORACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89513,"idioma_id":4,"titulo":"Complex Surface Chemistry of 4-Mercaptopyridine Self-Assembled Monolayers on Au(111)","resumen":"The adsorption of 4-mercaptopyridine on Au(111) from aqueous or ethanolic solutions is studied by different surface characterization techniques and density functional theory calculations (DFT) including van der Waals interactions. X- Ray Photoelectron Spectroscopy and electrochemical data indicate that self-assembly from 4-mercaptopyridine-containing aqueous 0.1 M NaOH solutions for short immersion times (few minutes) results in a 4-mercaptopyridine (PyS) self-assembled monolayer (SAM) with surface coverage 0.2. Scanning tunneling microscopy images show an island-covered Au surface. The increase in the immersion time from minutes to hours results in a complete SAM degradation yielding adsorbed sulfur and a heavily pitted Au surface. Adsorbed sulfur is also the main product when the self-assembly process is made in ethanolic solutions irrespective of the immersion time. We demonstrate for the first time that a surface reaction is involved in PyS SAM decomposition in ethanol, a surface process not favored in water. DFT calculations suggest that the surface reaction takes place via disulfide formation driven by the higher stability of the S-Au(111) system. Other reactions that contribute to  sulfidization are also detected and discussed.","palabras_clave":"Self-assembled monolayers|Au(111)|4-mercaptopyridine|Surface"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89514,"idioma_id":4,"titulo":"High Blood Pressure, Overweight and Obesity Among Rural Scholars from teh Vela Project. A population-based study from South America","resumen":"BACKGROUND: Many studies have shown that high blood pressure and overweight begins in childhood. Consequently, it is useful to know blood pressure and body mass index (BMI) values from an early age. There are few data about blood pressure control in children and adolescents from rural populations in South America. AIM: The objective of this study was to determine the prevalence of high blood pressure and its association with sedentary habits and overweight\/obesity in scholars from a rural population in Argentina. METHODS: The study population for this cross-sectional study was composed of rural children and adolescent scholars from Maria Ignacia Vela. Pre-hypertension and hypertension were defined on the basis of percentiles from the average of three blood pressure measurements taken on a single occasion. In patients with three blood pressure measurements above the 90th percentile, ambulatory blood pressure monitoring was performed to confirm hypertension or pre-hypertension. BMI was categorized by using the 2000 Centers for Disease Control and Prevention growth charts. RESULTS: We studied 334 scholars (aged 5-18 years). Mean age was 11.4 years. In 70% of the subjects, blood pressure had never been measured. The prevalence of high blood pressure was 4.4%. Students with sedentary habits were 3.67-fold more likely to develop high blood pressure than their physically active counterparts (odds ratio [OR] 3.67; 95% CI 1.08, 12.46; p = 0.037). Obese students were more likely to develop hypertension than the students with normal weight (OR = 5.17; 95% CI 1.52, 17.60; p = 0.02). Male students had a 3.4-fold higher risk of developing high blood pressure than females.CONCLUSIONS: In our rural population, the evaluation of blood pressure in children and adolescents is not a routine measure. Our data indicate a low prevalence of high blood pressure. These data could argue differences between rural and urban scholars. Our data demonstrate a close relationship between increased overweight, obesity and sedentary lifestyle with the development of high blood pressure. We emphasize the importance of blood pressure controls and the need to implement programmes to modify sedentary lifestyle in rural populations.","palabras_clave":"hypertension|pediatric obesity|pediatric overweight|rural"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89515,"idioma_id":5,"titulo":"Bienestar Subjetivo de los Adolescentes: Un Estudio Comparativo entre Argentina y Brasil","resumen":"El objetivo del presente estudio es conocer y comparar los niveles de bienestar subjetivo de adolescentes argentinos y brasileños. La muestra está compuesta por 640 adolescentes de ambos sexos con edades entre los 12 y 16 años, siendo el 46.3% argentinos y el 53.7% brasileños. Se han utilizado tres escalas: el Personal Wellbeing Index (PWI), la Satisfaction with Life Scale (SWLS) y la Brief Multidimensional Students? Life Satisfaction Scale (BMSLSS). El PWI y la BMSLSS mostraron puntuaciones más altas en los adolescentes argentinos (MPWI = 82.42 y MBMSLSS = 41.19) que en los brasileños (MPWI = 80.88 y MBMSLSS = 40.09), y mientras que la SWLS mostró resultados semejantes (MSWLS-Arg = 31.50 y MSWLS-Bra = 31.32). El análisis multivariado de variancia (MANOVA), revela que las tres escalas forman una variable estadística en su conjunto, mostrando diferencias significativas por país (p < .038) y por edad (p < .024), y evidenciando efectos de interacción significativa entre las dos variables (p < .008), pero no por sexo (p = .174), ni en la interacción entre país y sexo (p = .856). Se discuten las implicaciones de los resultados con relación al bienestar considerando el país, la edad y el sexo de los adolescentes.","palabras_clave":"bienestar subjetivo|satisfacción vital|jóvenes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89516,"idioma_id":5,"titulo":"Calidad de vida en Argentina: percepciones macro y micro sociales.","resumen":"  El artículo presenta los resultados de un estudio desarrollado en Argentina que diferencia la  opinión de ciudadanos acerca de su calidad de vida, para dicho estudio se tomaron en cuenta  dos zonas geográficas específicas, la Ciudad Autónoma de Buenos Aires y los Partidos del  Gran Buenos Aires. Se midió el nivel de satisfacción con la calidad de vida en el país y con la  calidad de vida personal a partir de la utilización de diferentes instrumentos: escala de satisfacci  ón con la calidad de vida en el país (ESCVP), escala de satisfacción con la vida (SWLS)  y encuesta de áreas vitales.","palabras_clave":"calidad de vida|satisfacción vital|acciones de gobierno"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89518,"idioma_id":4,"titulo":"Synthesis of aromatic stigmastanes: application to the synthesis of aromatic analogs of brassinosteroids","resumen":"In this paper, we report thefirst synthesis of aromatic analogs of brassinosteroids. In order to accomplish this task, we explored two different synthetic approaches, which involved demethylation of the C-19 of stigmasterol to yield A-ring aromatic 3-hydroxystigmastanes. One of the new aromatic analogs showed a reduced but significant bioactivity when compared to the natural hormones.","palabras_clave":"Brassinosteroids|Aromatic stigmastanes|A-ring|Bioactivity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89519,"idioma_id":4,"titulo":"Combining ability of flint corn inbred lines: Mal de Río Cuarto disease tolerance and grain yield","resumen":"Mal de Río Cuarto (MRC) disease is a significant  threat to corn production in Argentina. Sixty six hybrid combinations  derived from the cross of twelve flint maize (Zea mays L) inbred lines  were evaluated using a completely randomized block design with two  replications. MRC disease severity grade (SG) and grain yield (GY)  were the analyzed traits. Our objectives were to estimate the general  (GCA) and specific (SCA) combining abilities for these traits  among twelve corn inbred lines, and to identify potential heterotic  relationships among them. Diallel crosses were performed and these  results were compared using Griffing?s method 2 model I and diallel  GGE biplot (genotype main effect plus genotype x environment interaction).  Highly significant effects for GCA and SCA for SG were  observed, suggesting that both additive and non-additive genetic effects  contribute to MRC tolerance. At the same time, GY showed  significant effects only for SCA, hence non additive genetic effects  are more important determinants of grain yield. Using both analysis  methodologies, lines with good GCA to MRC tolerance and also  heterotic crosses for this trait and GY were identified. These promising  new crosses need further evaluation to assess their agronomic  performance in larger field trials and establish whether they remain  heterotic throughout an array of different productive environments,  before they are included in future breeding efforts.","palabras_clave":"Mal de Río Cuarto disease |Diallel crosses|GGE biplot|Combining"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89520,"idioma_id":4,"titulo":"Strontium doping in mullite-type bismuth aluminate: a vacancy investigation using neutrons, photons and electrons","resumen":"We report on strontium doped dibismuth-nonaoxoaluminate(III) produced at 1023 K. Partial substitution of bismuth by strontium in the structure yields oxygen vacancies for charge balance.Introducing oxygen vacancies rearranged the associated Al2O7 double-tetrahedra forming ??Al3O10?? tri-clusters which were identified by multi-quantum 27Al MAS NMR. Both STEM-EDX and XPS showed homogeneous distribution of strontium in the bulk and on the surface, respectively. Moreover, XPS confirms the valence state of bismuth after doping. The orientations of bismuth 6s2 lone electron pairs were calculated using DFT methods. The amount of strontium in the crystal structure was further confirmed from the decomposition product SrAl12O19 formed during the temperature-dependent X-ray powder diffraction. The structural proof was carried out by refining the structure of (Bi0.94Sr0.06)2Al4O8.94 from powder neutron and X-ray diffraction data. Rietveld refinements clearly showed the under occupation of one oxygen site and the shift of two aluminum atoms from the doubletetrahedra to two tri-cluster sites.","palabras_clave":"DIBISMUTH-NONAOXOALUMINATE|OXYGEN VACANCY|LONE ELECTRON PAIR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89521,"idioma_id":4,"titulo":"Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population","resumen":"The \u201Cthrifty genotype\u201D hypothesis proposes that the high prevalence of   type 2 diabetes (T2D) in Native Americans and admixed Latin Americans   has a genetic basis and reflects an evolutionary adaptation to a past   low calorie\/high exercise lifestyle. However, identification of the gene   variants underpinning this hypothesis remains elusive. Here we assessed   the role of Native American ancestry, socioeconomic status (SES) and 21   candidate gene loci in susceptibility to T2D in a sample of 876 T2D   cases and 399 controls from Antioquia (Colombia). Although mean Native   American ancestry is significantly higher in T2D cases than in controls   (32% v 29%), this difference is confounded by the correlation of   ancestry with SES, which is a stronger predictor of disease status.   Nominally significant association (P&lt;0.05) was observed for markers   in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a   significant bias (P&lt;0.05) towards OR&gt;1 was observed for markers   selected from previous T2D genome-wide association studies, consistent   with a role for Old World variants in susceptibility to T2D in Latin   Americans. No association was found to the only known Native   American-specific gene variant previously associated with T2D in a   Mexican sample (rs9282541 in ABCA1). An admixture mapping scan   with 1,536 ancestry informative markers (AIMs) did not identify genome   regions with significant deviation of ancestry in Antioquia. Exclusion   analysis indicates that this scan rules out ~95% of the genome as   harboring loci with ancestry risk ratios &gt;1.22 (at P &lt; 0.05).","palabras_clave":"Amerind Ancestry|Type 2 Diabetes"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89522,"idioma_id":4,"titulo":"Functional and Structural Effects of Seven-Residue Deletions on the Coiled-Coil Cytoplasmic Domain of a Chemoreceptor","resumen":"Chemoreceptors transmit signals from the environment to the flagellar motors via a histidine kinase that controls the phosphorylation level of the effector protein CheY. The cytoplasmic domain of chemoreceptors is strongly conserved and consists of a long alpha-helical hairpin that forms, in the dimer, a coiled-coil four-helix bundle. Changes in this domain during evolution are characterized by the presence of seven-residue insertions\/deletions located symmetrically with respect to the hairpin turn, suggesting that specific interactions between the helices that form the hairpin are required for function. We assessed the impact of seven-residue deletions on the signaling ability and higher-order organization of the serine chemoreceptor from Escherichia coli. Our results indicate that symmetry alterations between the two branches of the cytoplasmic hairpin seriously compromise chemoreceptor function. Shorter functional versions of Tsr with symmetrical deletions form mixed trimers of dimers when co-expressed with Tar, the aspartate receptor of E. coli. However, Tar function in those cells is impaired, suggesting that the length difference between receptors introduces non-functional distortions into the chemoreceptor cluster. This observation is reinforced by the analysis of co-expression of Tar with chemoreceptors from Rhodobacter sphaeroides that naturally belong to a shorter-length class.","palabras_clave":"Chemoreceptors|Heptad Indels|Receptor clusters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89523,"idioma_id":4,"titulo":"Bacterial swimming, swarming and chemotactic response to heavy metal presence: which could be the influence on wastewater biotreatment efficiency?","resumen":"Fixed-bed reactors are usually designed for wastewater biotreatments, where the biofilm establishment and maintenance play the most important roles. Biofilm development strictly relies on different types of bacterial motility: swimming, swarming, and chemotaxis, which can be altered by the microenvironment conditions. The aim of this work is to do an integrated study on the effects of Cu(II), Cd(II), Zn(II) and Cr(VI) on swimming, swarming and chemotaxis of Pseudomonas veronii 2E, Delftia acidovorans AR and Ralstonia taiwanensis M2 to improve biofilm development and maintenance for metal loaded wastewater biotreatment in fixed-bed bioreactors. Swimming, swarming and chemotactic response evaluation experiments were carried out at different metal concentrations. P. veronii 2E motility was not affected by metal presence, being this strain optimal for fixed-bed reactors. D. acidovorans AR swarming was inhibited by Cd and Zn. Although R..taiwanensis M2 showed high resistance to Cu, Cd, Cr and Zn, motility was definitively altered, so further studies on R. taiwanensis M2 resistance mechanisms would be particularly interesting.","palabras_clave":"MICROBE-METAL INTERACTIONS|BIOFILM ESTABLISHMENT|WASTEWATER BIOTREATMENT|SWIMMING|SWARMING|CHEMOTAXIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89524,"idioma_id":4,"titulo":"'Magnetic binary nanofillers'","resumen":"Magnetic binary nanofillers containing multiwall carbon nanotubes (MWCNT) and hercynite were synthesized by Chemical Vapor Deposition (CVD) on Fe\/AlOOH prepared by the sol?gel method. The catalyst precursor was fired at 450 °C, ground and sifted through different meshes. Two powders were obtained with different particle sizes: sample A (50?75 &#956;m) and sample B (smaller than 50 &#956;m). These powders are composed of iron oxide particles widely dispersed in the non-crystalline matrix of aluminum oxide and they are not ferromagnetic. After reduction process the powders are composed of &#945;-Fe nanoparticles inside hercynite matrix. These nanofillers are composed of hercynite containing &#945;-Fe nanoparticles and MWCNT. The binary magnetic nanofillers were slightly ferromagnetic. The saturation magnetization of the nanofillers depended on the powder particle size. The nanofiller obtained from powder particles in the range 50?75 &#956;m showed a saturation magnetization 36% higher than the one formed from powder particles smaller than 50 &#956;m. The phenomenon is explained in terms of changes in the magnetic environment of the particles as consequence of the presence of MWCNT.","palabras_clave":"CARBON NANOTUBES|HERCYNITE|MAGNETISM|NANOFILLERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89525,"idioma_id":4,"titulo":"Enhanced phytoextraction of chromium by the aquatic macrophyte Potamogeton pusillus in presence of copper","resumen":"The aquatic macrophyte, Potamogeton pusillus was evaluated for the removal of Cu2þ and Crþ6 from aqueous solutions during 15 days phytoextraction experiments.Results show that P. pusillus is capable of accumulating substantial amount of Cu and Cr from individual solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aqueous solutions during 15 days phytoextraction experiments.Results show that P. pusillus is capable of accumulating substantial amount of Cu and Cr from individual solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6Potamogeton pusillus was evaluated for the removal of Cu2þ and Crþ6 from aqueous solutions during 15 days phytoextraction experiments.Results show that P. pusillus is capable of accumulating substantial amount of Cu and Cr from individual solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6P. pusillus is capable of accumulating substantial amount of Cu and Cr from individual solutions (either Cu2þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ62þ or Crþ6). Significant correlations between metal removal and bioaccumulation were obtained. Roots and leaves accumulated the highest amount of Cu and Cr followed bystems. The bioaccumulation of Cr was significantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6ficantly enhanced in the presence of Cu, showing a synergic effect on Crþ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6þ6 removal, presenting a good alternative for the removal of these metals from polluted aquifers. To the extent of our knowledge, this is the first report on both enhanced phytoextraction of Crþ6first report on both enhanced phytoextraction of Crþ6 in presence of Cuþ2 and bioaccumulation of these heavy metals by P. pusillus.þ2 and bioaccumulation of these heavy metals by P. pusillus.","palabras_clave":"chromium|phytoextraction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89526,"idioma_id":4,"titulo":"Use of biomonitors for the identification of heavy metals emission sources","resumen":"Heavy metals accumulation by Tillandsia capillaris was measured to identify their main emission sources in the province of Córdoba, Argentina. Samples of T. capillaris collected over three years at different sites were analysed by &#64258;ame atomic absorption spectrometry to determine the amounts of Cu, Fe, Ni, Mn, Pb and Zn. The sampling sites were categorized according to land use, anthropic activities and\/or distance from the potential heavy metal emission sources. We found that the concentration of heavy metals in the study area is mainly driven by industrial activity while traf&#64257;c contributed only to the levels of Zn.In addition, we observed a strong relationship between a diffuse emission source and the content of Pb accumulated on the biomonitors which could be attributed to dove hunting activities. Future studies are needed to con&#64257;rm this hypothesis.","palabras_clave":"Tillandsia capillaris|Passive biomonitoring|heavy metals|Air pollution sources"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89527,"idioma_id":4,"titulo":"Heavy metals and trace elements in atmospheric fall-out: Their relationship with topsoil and wheat element composition","resumen":"The objectives of this study were to determine the average   concentrations and deposition rates of 28 elements in atmospheric bulk   deposition and to elucidate associations among topsoil, bulk deposition   and wheat element composition. The fluxes of arsenic (As), copper (Cu),   lead (Pb) and zinc (Zn) deposition in Córdoba were higher than in other   agro-ecosystems, which reflects both natural (geochemistry and topsoil   removal) and anthropogenic sources. High lanthanide, uranium (U) and   thorium (Th) concentrations revealed the impact of an open cast uranium   mine. The highest enrichment factors (EF) were those of Cu, Pb, Zn and   nickel (Ni), with calcium (Ca) being the most prominent in the   surroundings of a cement plant. Industries and the transport of airborne   urban pollutants were the main anthropogenic sources for Ca, Cu, Ni,   Pb, Zn, cadmium (Cd), iron (Fe), manganese (Mn) and antimony (Sb). The   concentrations of metals in wheat grain were predicted using the topsoil   and atmospheric fall-out composition with R2&nbsp;=&nbsp;0.90, with   the latter being the best explanatory variable. The present study   highlights the potential health hazards of wheat consumption   (Environmental Protection Agency) by the assessment of heavy metals in   bulk atmospheric deposition","palabras_clave":"BULK DEPOSITION|CEMENT PLANT|INDUSTRIAL INCENERATOR|TRITICUM AESTIVUM|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89528,"idioma_id":4,"titulo":"Fluoride biomonitoring around a large aluminium smelter in Argentina using foliage from different tree species","resumen":"In order to study the pollution gradient in the vicinity of a large aluminium productionfacility in Patagonia (Argentina), a passive biomonitoring was performed employingfoliage from three tree species. Primary scope was to identify pollution gradients and toselect suitable tree species which can be used as biomonitor plants in the study area.Therefore, leaves of Eucalyptus rostrata, Populus hybridus and different needle ages of Pinusradiata were collected at different distances from the industry and the fluoride concentrationwas analysed in washed and unwashed samples in order to determine theamount of external fluoride. Washing reduced the F-concentrations by 24, 39 and 51%on average in E. rostrata, P. hybridus and P. radiata, respectively, indicating that speciesspecificcharacteristics determine the accumulation and wash-off of dust-associatedfluorine. F-concentrations varied from 6 to 3652 ppm F in unwashed samples indicatinga steep pollution gradient in the study area. The influence of F-emissions was discerniblein all samples up to a distance of 3500m from the smelter. E. rostrata accumulatedmore fluorine than the other species at equal distance from the emission source. Thepresent study confirms that aluminium smelting results in high F deposition in thestudy area. Establishing a biomonitor network around large emitters is suitable andfeasible to evaluate the efficiency of air control measures.Eucalyptus rostrata, Populus hybridus and different needle ages of Pinusradiata were collected at different distances from the industry and the fluoride concentrationwas analysed in washed and unwashed samples in order to determine theamount of external fluoride. Washing reduced the F-concentrations by 24, 39 and 51%on average in E. rostrata, P. hybridus and P. radiata, respectively, indicating that speciesspecificcharacteristics determine the accumulation and wash-off of dust-associatedfluorine. F-concentrations varied from 6 to 3652 ppm F in unwashed samples indicatinga steep pollution gradient in the study area. The influence of F-emissions was discerniblein all samples up to a distance of 3500m from the smelter. E. rostrata accumulatedmore fluorine than the other species at equal distance from the emission source. Thepresent study confirms that aluminium smelting results in high F deposition in thestudy area. Establishing a biomonitor network around large emitters is suitable andfeasible to evaluate the efficiency of air control measures.were collected at different distances from the industry and the fluoride concentrationwas analysed in washed and unwashed samples in order to determine theamount of external fluoride. Washing reduced the F-concentrations by 24, 39 and 51%on average in E. rostrata, P. hybridus and P. radiata, respectively, indicating that speciesspecificcharacteristics determine the accumulation and wash-off of dust-associatedfluorine. F-concentrations varied from 6 to 3652 ppm F in unwashed samples indicatinga steep pollution gradient in the study area. The influence of F-emissions was discerniblein all samples up to a distance of 3500m from the smelter. E. rostrata accumulatedmore fluorine than the other species at equal distance from the emission source. Thepresent study confirms that aluminium smelting results in high F deposition in thestudy area. Establishing a biomonitor network around large emitters is suitable andfeasible to evaluate the efficiency of air control measures.E. rostrata, P. hybridus and P. radiata, respectively, indicating that speciesspecificcharacteristics determine the accumulation and wash-off of dust-associatedfluorine. F-concentrations varied from 6 to 3652 ppm F in unwashed samples indicatinga steep pollution gradient in the study area. The influence of F-emissions was discerniblein all samples up to a distance of 3500m from the smelter. E. rostrata accumulatedmore fluorine than the other species at equal distance from the emission source. Thepresent study confirms that aluminium smelting results in high F deposition in thestudy area. Establishing a biomonitor network around large emitters is suitable andfeasible to evaluate the efficiency of air control measures.E. rostrata accumulatedmore fluorine than the other species at equal distance from the emission source. Thepresent study confirms that aluminium smelting results in high F deposition in thestudy area. Establishing a biomonitor network around large emitters is suitable andfeasible to evaluate the efficiency of air control measures.","palabras_clave":"Eucalyptus|Fluoride bioindication|Patagonia|Pinus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89529,"idioma_id":4,"titulo":"In vitro activity of dried extracts of Nepeta cataria against Helicobacter pylori strains","resumen":"Abstract  Nepeta cataria L. (Lamiaceae) is widely used in popular medicine for the treatment of several gastrointestinal  disorders. Drying procedures were applied to infusions prepared at 10% and 15% (w\/v) from dried grounded  aerial parts of Nepeta cataria. Freeze-drying extracts (FDEs) and spray-dried extracts (SDEs) were obtained.  The activity against H. pylori of SDEs and FDEs was evaluated. FDEs were active against H. pylori in the  three strains evaluated at 10 and 0.31 mg\/ml. SDEs were not active against H. pylori at any concentration.  Chemical fingerprints were achieved by Capillary Electrophoresis (CE). The infusion, SDE and FDE profiles showed a similar chemical composition. However, at 6.1 min, a peak with analogous corrected area was detected in the infusion and FDE profiles; in addition it was not found in the SDE. In the FDE samples the main components concentration was lower than in the infusion and SDE samples. The highest concentration of the metabolites was found in the SDE samples.  Minor components of the infusion that are not present after the spray drying procedure can be related with the antibacterial activity. Further research aimed the identification and purification of anti-H. pylori  components from the N. cataria are necessary as well as to determine the degree of toxicity of these extracts","palabras_clave":"Nepeta cataria| Helicobacter pylori|dried extracts|capillary electrophoresis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89530,"idioma_id":4,"titulo":"A late Paleozoic fossil forest from the southern Andes, Argentina","resumen":"An anatomical and ecological study of a Late Pennsylvanian\u2013early Permian assemblage of silicified trunks from the San Ignacio Formation of southern Andean Cordillera is detailed. This stratigraphic unit has been divided in three facies associations. The silicified trunks are abundant in the middle part of the facies association C (limestones, shales and volcanics) forming a persistent forested stratigraphic level. Anatomical information integrated with sedimentological data, has allowed reconstruction of a plant community that grew on the westernmost margin of Gondwana. The paleoforest grew in wetland environments, where a taphocoenosis of only permineralized trunks and stumps has been preserved. Based on characters of the stem and roots the trees are cordaitaleans, though distinct from other members of this group. Vascular traces exhibit tracheids arranged in circular patterns indicating auxin regulation of axial growth and probably the presence of epicormic shoots. These fossil trees also preserve anatomical evidence of plant\u2013arthropod interactions and rootlets invading the decaying wood. Indistinct growth rings as well as additional indirect evidence indicate that this ecosystem experienced an overall humid, warm climatic regime.","palabras_clave":"Late Paleozoic|Gondwana|Trees|Anatomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89531,"idioma_id":4,"titulo":"Depositional environments and vegetation of Aptian sequences affected by volcanism in Patagonia","resumen":"The continental deposits of the Baqueró Group preserve one of the most   abundant Aptian floras on the southern margins of Gondwana. These floras   represent an extinct biome that was subject to increasing regional   volcanism. In combination with the presence of shallow water bodies,   this biome provided suitable environments for the preservation of   imprints and compressions of foliage together with permineralized trunks   and palynofloras. Eight facies associations were identified in nine   sections, characterizing the evolution of lacustrine and fluvial   environments under intense volcanic activity. In addition, three   depositional sequences were defined, with the purpose of establishing a   chronostratigraphic framework to which the positions of the   fossiliferous levels identified in the different sections can be   referred. A 206Pb\/238U age of 114.67&nbsp;±&nbsp;0.18&nbsp;Ma   from the upper depositional sequence constrains the succession as no   younger than the late Aptian and probably represents an interval of   4\u20135&nbsp;Myr, during which the vegetation was affected by increasing biotic   stress conditions. A qualitative analysis of the palynological   assemblages and plant remains allowed a reconstruction of the dynamics   of the vegetation developed during the deposition of the Baqueró Group.   Volcanic activity appears to have had relatively moderate effects on the   biota, at least at the Order level. Nevertheless, low species richness   is observed toward the top of the Baqueró Group, reflecting an increase   in adverse environmental conditions. The possible interpretations of the   assemblages identified as biozones or, in contrast, biofacies related   to changeable environmental conditions are discussed herein.","palabras_clave":"Aptian|Baquero Group|Sequence stratigraphy|Palynology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89532,"idioma_id":4,"titulo":"Fossil woods (Coniferales) from the Baqueró Group (Aptian), Santa Cruz Province, Argentina","resumen":"Two new conifer morphospecies represented by a secondary xylem are reported for the Lower Cretaceous Baqueró Group (Santa Cruz Province, Argentina). Agathoxylon sp. is characterized by poorly defined growth rings, predominantly uniseriate pitting in the radial wall of the tracheids, cross fields with 1-6 pits and uniseriate rays. These features are shared with the leafy branches described for the unit as Araucaria grandifolia Feruglio emend. Del Fueyo and Archangelsky. The second taxon, Brachyoxylon sp. cf. B. boureaui, possesses poorly defined growth rings, mixed wood with predominantly uniseriate radial pitting, cross fields with 8-26 pits and uniseriate rays. These taxa represent the first fossil woods described for Baqueroan strata.","palabras_clave":"Fossil woods|Lower Cretaceous|Patagonia|Baqueró Group"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89533,"idioma_id":5,"titulo":"Del anonimato al Nobel: pasado, presente y futuro de un microorganismo paradigmatico","resumen":"Helicobacter pylori es un microorganismo que fue aislado por primera vez en abril de 1982 obligando a una revisión de las ideas y prejuicios sobre las patologías gástricas. Su historia empieza a escribirse a fines del siglo XIX cuando varios investigadores informaron de su presencia en el estómago de animales y poco después bacterias similares se observaron en los seres humanos, algunos de ellos con úlcera péptica o cáncer gástrico. Continuó en la década de 1980 cuando Barry Marshall y Robin Warren, gastroenterólogos australianos, fueron capaces de demostrar en pacientes con gastritis y úlcera gástrica, la presencia de un microorganismo con forma curvada semejante a Campylobacter, logrando cultivarlo por primera vez a partir de muestras de biopsias gástricas. No cabe duda que hubo un antes y un después a partir del descubrimiento de H. pylori para la comunidad científica, ya que produjo un profundo cambio el reconocer que la úlcera peptídica podía estar causada por un microorganismo y tener que abandonar la idea de una afección psicosomática, a menudo hereditaria, cuyo único remedio en casos graves era la cirugía. Lograr la aceptación de una nueva teoría no fue nada fácil, esto implico renunciar con las ideas ya establecidas un ejercicio que en el mundo científico no siempre se realiza con gran facilidad.&nbsp; El H. pylori y la magnitud del efecto potencial que tiene sobre la población humana, es un claro ejemplo de que ningún dato se puede tomar como dogma de fe, la naturaleza nos sorprende con su versatilidad en muchas de sus formas\u2026 y si se la subestima, nos toma por sorpresa.","palabras_clave":"HELICOBACTER|PYLORI|MARSHALL|WARREN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89534,"idioma_id":4,"titulo":"Stem transcriptome reveals mechanisms to reduce the energetic cost of shade-avoidance responses in tomato","resumen":"While the most conspicuous response to low red\/far-red ratios (R:FR) of shade light perceived by phytochrome is the promotion of stem growth, additional, less obvious effects may be discovered by studying changes in the stem transcriptome. Here, we report rapid and reversible stem transcriptome responses to R:FR in tomato (Solanum lycopersicum). As expected, low R:FR promoted the expression of growth-related genes, including those involved in the metabolism of cell wall carbohydrates and in auxin responses. In addition, genes involved in flavonoid synthesis, isoprenoid metabolism, and photosynthesis (dark reactions) were overrepresented in clusters showing reduced expression in the stem of low R:FR-treated plants. Consistent with these responses, low R:FR decreased the levels of flavonoids (anthocyanin, quercetin, kaempferol) and selected isoprenoid derivatives (chlorophyll, carotenoids) in the stem and severely reduced the photosynthetic capacity of this organ. However, lignin contents were unaffected. Low R:FR reduced the stem levels of jasmonate, which is a known inducer of flavonoid synthesis. The rate of stem respiration was also reduced in low R:FR-treated plants, indicating that by downsizing the stem photosynthetic apparatus and the levels of photoprotective pigments under low R:FR, tomato plants reduce the energetic cost of shadeavoidance responses. © 2012 American Society of Plant Biologists. All Rights Reserved.","palabras_clave":"Transcriptome|phytochrome"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89535,"idioma_id":4,"titulo":"Mimosa diversipila var. subglabriseta (Mimosoideae, Leguminosae), a new record for the flora of Paraguay","resumen":"The presence of Mimosa diversipila M. Micheli var. subglabriseta Barneby &amp; Fortunato is nowreported for first time in Paraguay. A revision of Barneby\u2019s initial description of the variety and photographsof one of the Paraguayan specimens are given in this paper","palabras_clave":"Leguminosae|Mimosa|Mimosa diversipila|Paraguay"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89536,"idioma_id":4,"titulo":"Hierarchical ZnO nanostructures: Growth mechanisms and surface correlated photoluminescence","resumen":"ZnO nanowires were grown by vapor-transport and deposition on Au nanocluster covered fused andthermal silica and c-Si. The nanowire size and density depended strongly on the substrate type. Bydecreasing the O2 to local Zn partial pressure ratio, the growth pattern changed to nanocombs andnanosheets. ZnO nanohedgehogs were found on bare c-Si. We observe a remarkable correlationbetween the defect to exciton photoluminescence intensity ratio and the nanostructures specific surfaceareas. These results indicate that changes in strain and O deficiency defects at surfaces are behind theobserved morphology changes, one to two-dimensional growth transition, and correspondingluminescence.","palabras_clave":"ZnO|nanostructure|photoluminiscence|deffects"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89537,"idioma_id":5,"titulo":"Ibalia leucospoides parasitoide de Sirex noctilio en Córdoba - Argentina","resumen":"Ibalia leucospoides es un parasitoide en sus estadios inmaduros y de vida libre como adulto, considerado como el más eficiente en el control de Sirex noctilio. Para evaluar el grado de parasitismo, durante cuatro períodos (entre los años 1997-2001) se colocaron dos trozas de 1 m cada una atacadas por S. noctilio dentro de jaulas trampa dispuestas en el campo y laboratorio, dondese capturaron los adultos de I. leucospoides. Para cada período de muestreo se realizó el análisis de varianza según un diseño de parcelas divididas en el tiempo, siguiendo la estructura de parcelas en bloques. La relación entre ambas especies se evaluó mediante correlación de Pearson. Las variables sexo y lugar no registraron diferencias significativas, mientras que las emergencias de I. leucospoides en cada fecha de muestreose modificaron en el tiempo. Con respecto a la proporción de sexo, no se observaron diferencias significativas, aunque en general prevalecieron los machos sobre las hembras. El parasitoide I. leucospoides es el único controlador biológico establecido en la región presentando una fuerte y positiva asociación con el comportamiento de S. noctilio.","palabras_clave":"IBALIA LEUCOSPOIDES|FLUCTUACION POBLACIONAL|PROPORCIÓN DE SEXOS|SIREX NOCTILIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89538,"idioma_id":4,"titulo":"Taxonomy and Systematics of fungi from South America  \u2013a special issue in honoring Leif Ryvarden: Introduction","resumen":"Since the ending of the nineteen century and the beginning of the last one, pioneered by mycologists such as Carlos Spegazzini, A. Giacomo Bresadola, Johann Rick and Miles Joseph Berkeley, mycological research in South America has grown vigorously and continues in the present time. Numerous taxa have been described, many papers have been published, and several regional mycotas have been produced.One of the major contributors in this field is Professor Leif Ryvarden, who has made substantial contributions to the knowledge of polypore diversity in his series of articles Neotropical polypores, where he describes patterns of polypore distribution and putforth clever hypotheses about the processes behind those patterns. In addition he worked closely with several local mycologists (Fig. 1). The contributions of Dr. Ryvarden are not restricted to South America or to polypores. It would be a quite difficult task to enumerate Ryvarden´s overall contributions to the field of mycology, but for any mycologist it is clearly evident that his contributions \u2013more than three hundred published articles and books\u2013 extend all around the world and substantially improved our knowledge on fungal diversity on a global scale.It is for this reason that we have dedicated this special issue of Kurtziana to Professor Leif Ryvarden in honour of his devotion to South American mycology.","palabras_clave":"Taxonomy|Suoth America|Ryvarden|Micology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89539,"idioma_id":4,"titulo":"Practical Assessment Scheme to Service Selection for SOC-based Applications","resumen":"Service-Oriented Computing promotes building applications by consuming  reusable services. However, facing the selection of adequate services for a specific application still is a major challenge. Even with a reduced set of candidate services, the assessment effort could be overwhelming. On a previous work we have presented a novel approach to assist developers on discovery, selection and integration of services. This paper presents the selection method, which is based on a comprehensive scheme for services´ interfaces compatibility. The scheme allows developers to gain knowledge on likely services´ interactions and their  required adaptations to achieve a positive integration. The scheme is also complemented by a framework based on black-box testing to verify compatibility on the expected behavior of a candidate service. The usefulness of the selection method is highlighted through a series of case studies.","palabras_clave":"Service oriented Computing|Component-based Software Engineering|Web Services"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89540,"idioma_id":4,"titulo":"Optimization of a carbon nanotubes manufacturing process by the technique of PECVD","resumen":"Carbon nanotubes (CNT) are valuable for their application in nanotechnology, electrical properties and high surface area, and in our particular case, for the manufacture of nanosensors. In this work the technique of Plasma Enhanced Chemical Vapor Deposition (PECVD) was used for the manufacture of CNT. The process was conducted in a horizontal tube reactor using methane as precursor gas and an R.F. discharge of 1000w output power acting as ionizing medium. Having achieved the synthesis of CNT on copper (Cu) substrates, heated with an internal electrical resistance to a process temperature of 900°C, the substrates were coated with ferric nitrate Fe(NO3)3, which served as a catalyst and nucleation center. The heating system used differs from traditional methods by its internal heating. Growth of CNT was achieved on vertical walls on Cu substrates and perpendicular to it; a prerequisite for the manufacture of nanosensors, which is the main objective of this work, as well as to reduce as much as possible the diameter of the CNT, being its main features 5&nbsp;ìm average length and 7&nbsp;nm average diameter.","palabras_clave":"PLASMA CVD|NANOTUBES|NANOSENSORS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89541,"idioma_id":4,"titulo":"The Bajada del Diablo astrobleme-strewn field, Argentine Patagonia: extending the exploration to surrounding areas","resumen":"The Bajada del Diablo astrobleme-strewn field is a huge domain of enigmatic circular structures located in Central Patagonia.  Three more localities are herein described, adding to the first area studied so far (Acevedo et al., 2009).  Taking into consideration the four areas, a single, blurred crater dispersion ellipse has been identified.  The four sectors have been now investigated, mapped and georeferred, and their circular structures,with a total of 189, some of them partially obliterated by erosion or sediment accumulation, were identified by remote sensing techniques, but many of them have been evaluated in situ and interpreted as impact craters. Moreover, two of the structures have been surveyed in detail in the field using a total station instrument.  In addition to the previously known occurrence of circular structures on the Eruptive Complex Quiñelaf (Miocene basalts), the Pampa Sastre Fm. (Pliocene conglomerates) and the Pleistocene pediment gravels and sands, and the geomorphological inferences that have suggested the extraterrestrial origin of this event (since no other natural Earth surface process could be responsible of their formation), it should be now added the recurrent absence of the Pliocene stratigraphic unit at  the bottom of the craters found on the pediment gravel and sands . Its removal has been interpreted as directly related to the impact, according to the magnetometric record of existing magnetic anomalies.  Other preliminary observations on the collected samples, glass, breccias and, most relevant, Fe-Nibearing spherules picked up within the impact zones, are herein discussed.  Two hypotheses have been put forward about the nature of the possible impacting object that formed these astroblemes which, fragmented in hundreds of pieces, hit the surface of the Earth perhaps in  Middle Pleistocene times. One of them is related to a desintegrated asteroid of the rubble-pile type, whereas the second hypothesis refers to the collision of a split comet with the Earth surface, being this  the most probable since no meteorite fragments have been found so far.","palabras_clave":"ASTROBLEME-STREWN FIELD|PLEISTOCENE|BAJADA DEL DIABLO|PATAGONIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89542,"idioma_id":4,"titulo":"Experimental Study of Tautomeric Equilibria of 2-Cyanobenzoic Acids in Gas, Solution and Solid Phase","resumen":"2-cyanobenzoic acids are very important compounds in several sciences, and it is because of this that studying their tautomeric equilibria is of great interest. Ring-chain tautomeric equilibria of 2-, 3- and&nbsp; 4-cyanobenzoic, 3-benzyl-2-cyanobenzoic and 1-cyano-2-naphthoic acids were studied in gas phase by means of mass spectrometry (MS). Furthermore, evidences of ring-chain tautomerism of&nbsp; 2-cyanobenzoic acid were found in solution using 1H and 13C nuclear magnetic resonance and in solid phase by infrared spectroscop.","palabras_clave":"Cyanobenzoic acids|mass spectrometry|NMR|infrared spectroscopy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89543,"idioma_id":4,"titulo":"Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover","resumen":"Ethanol has been known to affect various behavioral parameters in experimental animals, even several hours after ethanol (EtOH) is absent from blood circulation, in the period known as hangover. The aim of this study was to assess the effects of acute ethanol hangover on motor performance in association with the brain cortex energetic metabolism. Evaluation of motor performance and brain cortex mitochondrial function during alcohol hangover was performed in mice 6 hours after a high ethanol dose (hangover onset). Animals were injected i.p. either with saline (control group) or with ethanol (3.8 g\/kg BW) (hangover group). Ethanol hangover group showed a bad motor performance compared with control animals (p &lt; .05). Oxygen uptake in brain cortex mitochondria from hangover animals showed a 34% decrease in the respiratory control rate as compared with the control group. Mitochondrial complex activities were decreased being the complex I-III the less affected by the hangover condition; complex II-III was markedly decreased by ethanol hangover showing 50% less activity than controls. Complex IVwas 42% decreased as compared with control animals. Hydrogen peroxide production was 51% increased in brain cortex mitochondria from the hangover group, as compared with the control animals. Quantification of the mitochondrial transmembrane potential indicated that ethanol injected animals presented 17% less ability to maintain the polarized condition as compared with controls. These results indicate that a clear decrease in proton motive force occurs in brain cortex mitochondria during hangover conditions. We can conclude that a decreased motor performance observed in the hangover group of animals could be associated with brain cortex mitochondrial dysfunction and the resulting impairment of its energetic metabolism.","palabras_clave":"Ethanol hangover|Motor coordination|Mitochondria"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89544,"idioma_id":4,"titulo":"Fe-pillared Clay adsorption of picloram herbicide","resumen":"The adsorption of picloram on Fe Oxide Pillared Clays (PILC) as a possible basis for the development of adsorbentmaterials for the remediation of polluted environments was studied. To this end, after characterizingPILC obtained from raw clay from Wyoming, USA by XRD, elemental analysis, Mössbauer spectroscopy,DTA, TGA and N2 adsorption (BET), the picloram adsorption was studied at constant pH and ionic strengthafter 48 h equilibration with an aqueous solution of PCM. PCM adsorbed samples were characterized bySEM, zeta-potential vs pH functions, FTIR and TGA-DTA and the adsorption was modellated using Langmuirand Freundlich models.The results reveal that the surface area and interlayer space of PILC are bigger than those of raw montmorillonite.An analysis of the adsorption isotherms of picloram on the PILC showed that picloram adsorptionincreases with decreasing pH. The adsorption of PCM on PILC was 150 times higher than that found forraw montmorillonite under similar conditions. The zeta-potential vs pH functions shape and FTIR indicatedthat PCM coordinates the surface iron centers throughout pyridinic nitrogen atom forming inner-spherecomplexes. The much greater PCM adsorption on PILC turns the process into an excellent candidate tobe used for dosing or remediation of pesticides.","palabras_clave":"Picloram|Fe-pillared clay|Adsorption |Herbicide"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89545,"idioma_id":4,"titulo":"Synthesis and characterization of novel polyampholyte and polyelectrolyte polymers containing imidazole, triazole or pyrazole","resumen":"Novel soluble and non-soluble polymers based on methacrylic acid, ethylene glycol diglycidyl ether andpyrazole, triazole or imidazole were obtained by a one-spot synthetic strategy. The new materials werecharacterized by spectroscopic techniques (FT-IR, and solution- and solid-state NMR). Evidence on thecovalent binding of the different heterocycles to the non-soluble matrix was given by the unequivocalassignment of the 13C solid-state NMR spectra. Proton relaxation times in the rotating frame and twodimensionalwideline separation (1H-13C WISE) NMR spectra were used to assess their moleculardynamics. The higher synthetic yield of polyampholytes bearing triazole or pyrazole correlated witha lower molecular motion and a higher cross-linking degree. The polyelectrolyte effect of these materialswas exhaustively explored through the acid-base properties, swelling and zeta potential. The quaternizationof heterocyclic residues, responsible for adsorptive properties, was studied taking into accountthat these materials are attractive for analytical, environmental and biotechnological processes.","palabras_clave":"Polyamphlyte|Polyelectrolyte|Polymers|Imidazole"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89546,"idioma_id":4,"titulo":"The relative contributions of diet and associated microbiota to the accumulation of UV-absorbing mycosporine-like amino acids in the freshwater copepod Boeckella antiqua","resumen":"    1. Mycosporine-like amino acids (MAAs) are  ubiquitous compounds in aquatic organisms that are usually considered  sunscreens that protect them from harmful ultraviolet radiation. Given that virtually  all animals lack the metabolic pathways to synthesise MAAs de novo, they must acquire them either from their  diet or from microorganisms living in close association. In freshwater copepods,  accumulation of MAAs is stimulated by exposure to ultraviolet and&#8260; or visible radiation.    2. A 2 X 2 factorial experiment  was performed to assess the contributions of dietary and microbial sources of  MAAs in the freshwater copepod Boeckella antiqua. The treatments consisted of two different  diets: an MAA-free diet, including only Chlamydomonas  reinhardtii,  and an MAA-rich diet, including both C. reinhardtii and Peridinium inconspicuum, crossed with two antibiotic treatments, with  and without chloramphenicol. Treatment with chloramphenicol was intended to  inhibit the development of bacteria associated with the copepods.    3. MAA concentration in B. antiqua was affected by the  experimental conditions: (i) exposure to artificial PAR + UVR stimulated the  accumulation of several MAAs (up to 62% increase in total MAA  concentration with respect to the initial concentration); (ii) the presence of  chloramphenicol in the culture media reduced the MAA concentration in copepods  fed an MAA-free diet; (iii) in the absence of chloramphenicol, copepods fed the  MAA-rich diet had significantly higher total MAA concentration than those fed  the MAA-deficient diet; but (iv) dietary supplementation with an MAA-rich algae  in the presence of chloramphenicol failed to significantly increase total MAA concentration.    4. Analysis of profiles from denaturing  gradient gel electrophoresis (DGGE) showed that the prokaryotic community  associated with the copepods was affected by chloramphenicol. Dendograms  constructed from digitalised DGGE images consistently grouped the antibiotics treatments  separately from the initial samples and the treatments without antibiotics. Two  band positions were exclusive to treatments without antibiotics.    5. We conclude that when offered an  MAA-rich diet, B. antiqua may accumulate a proportion of MAAs from diet.  However, we suspect that in the absence of an MAA-rich dietary source (as in  its natural habitat), virtually all MAAs present in B. antiqua are produced by copepod-associated prokaryotes","palabras_clave":"ANTIBIOTIC|DGGE|DYNOFLAGELLATE|MAAS|PROKARYOTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89547,"idioma_id":5,"titulo":"Relación entre condiciones habitacionales y mortalidad infantil en la provincia del Chaco (Argentina). Determinación de diferentes escenarios posibles","resumen":"Las condiciones de la vivienda han sido reconocidas como una de las principales  determinantes sociales de la salud humana. Las deficiencias en la vivienda y el saneamiento constituyen un determinante reiterado del exceso de mortalidad y una característica sistemáticamente vinculada a los niveles de pobreza, el rezago socioeconómico y la inequidad territorial en América Latina y el Caribe.  El presente trabajo tiene como objetivo obtener una clasificación de las áreas programáticas de la provincia del Chaco en función de sus características habitacionales y niveles de mortalidad infantil; mediante el análisis de componentes principales y el análisis de cluster.  La provincia del Chaco, se sitúa en el nordeste de la República Argentina e integra la región del Norte Grande Argentino. Geopolíticamente pertenece a un área periférica, con una débil y estacionaria economía, ubicándose entre las provincias más deficitarias.","palabras_clave":"MORTALIDAD INFANTIL|CONDICIONES HABITACIONALES|CHACO|ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89548,"idioma_id":4,"titulo":"High-speed tunable photonic crystal fiber based femtosecond soliton source without dispersion pre-compensation","resumen":"We present a high-speed wavelength tunable photonic crystal fiber-based source capable of generating tunable femtosecond solitons in the infrared region.&nbsp;Through measurements and numerical simulation, we show that both the pulsewidth and the spectral width of the output pulses remain nearly constant over the entire tuning range from 860 to 1160 nm.&nbsp;This remarkable behavior is observed even when pump pulses are heavily chirped (7400 fs^2), which allows to avoid bulky compensation optics, or the use of another fiber, for dispersion compensation usually required by the tuning device.","palabras_clave":"Photonic Crystal Fiber|Optical Solitons|Femtosecond Pulses"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89549,"idioma_id":4,"titulo":"Morpholine sulfur trifluoride: Vibrational spectra, conformational properties and crystal structure","resumen":"Analysis of the vibrational spectra and quantum chemical calculations for morpholine sulfur trifluoride,SF3N(CH2CH2)2O, demonstrate that the morpholine ring possesses chair conformation and occupies an equatorial position of the trigonal bipyramidal SF3 group. The compound exists in the gas phase as a mixture of two conformers. The conformer with the SF3 group in equatorial orientation relative to the sixmembered  morpholine ring is slightly more stable than the axial conformer and the equilibrium is surprisingly temperature independent. MP2 and B3LYP calculations with cc-pVTZ basis sets predict free energy differences DG° = G°ax _ G°eq of +0.18 and +0.40 kcal\/mol, respectively. At temperatures below 12 °C the title compound crystallizes and the structure of the equatorial conformer, which is the only form present in the crystal, was determined by X-ray diffraction. At 131(1) K a phase transition occurs  and the low and high temperature forms were studied at 100 and 150 K, respectively.","palabras_clave":"MORPH-SF3|MATRIX IR SPECTRA|LOW TEMPERATURE RAMAN SPECTRA|X-RAY CRYSTALLOGRAPHY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89550,"idioma_id":4,"titulo":"Combustion synthesis of Co 3 O 4  nanoparticles:   fuel ratio effect on the physical properties of the resulting  powders","resumen":"Co3O4 nanoparticles have been obtained by stoichiometric combustion synthesis: in particular four nitrates-aspartic routes, each with different fuel ratio (ranging 0.5-2.5) have been studied. It has been determined through XRD that the crystalline structure present in all obtained powders was the face-centered cubic corresponding to Co3O4 and it has been evaluated an average crystallite size ranging between 21 and 76 nm. As regards to the effect of fuel ratio on physical properties, an increment on the crystallite average size and a drop on the specific surface area with the increase of the fuel ratio has been observed.","palabras_clave":"Co3O4 nanoparticles|combustion synthesis|fuel ratio|aspartic acid"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89551,"idioma_id":4,"titulo":"Morphology and structure of zirconia-ceria based nanopowders  synthesised by nitrates-EDTA and nitrates-TRIS gel-combustion  routes","resumen":"Gel-combustion syntheses (GCPs) employing different fuels are widely recognized in the literature because of their versatility, low cost and experimental flexibility. Besides, they allow to obtain a large amount of a pure, homogeneous nanopowder in a single batch process.In a previous work the authors reported new GCPs for zirconia-ceria nanopowders, syntheses based on nitrates-EDTA and nitrates-TRIS and preliminary results of morphology and structures of the different, obtained powders calcined at selected temperatures. In this article, new results about morphological and structural characterization of nanopowders obtained by fuel-rich and stoichiometric, nitrates-EDTA and nitrates-TRIS GCPs, mainly calcined at 600°C\/2 h, are informed. The characterizations were performed by SEM, TEM, DRX and SBET techniques.By XRD, the expected retention of the metastable, tetragonal phase was established in ZrO2-rich, calcined nanopowders (ZrO2-15mol%CeO2), meanwhile, in CeO2-rich, calcined nanopowders (ZrO2-90mol%CeO2) the usually expected, thermodynamically stable, cubic phase was obtained.By SEM, typical agglomerates of variable morphology were observed, depending on the GCP\/composition choice. By TEM the detailed nanostructure of the nanocrystallites aggregation was observed.In all cases, single-phased, homogeneous in composition, nanostructured powders were obtained. Some of them exhibit excellent properties, such as medium-high range specific surface area, for potential application in catalysis and SOFC technology.","palabras_clave":"Ceramic nanopowders |gel combustion routes|GCPs|fuel-rich combustion process|stoichiometric process"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89552,"idioma_id":5,"titulo":"Paleoambientes sedimentarios la Formación Toro Negro (Neógeno), antepaís fracturado andino, noroeste argentino","resumen":"La Formación Toro Negro (Neógeno) registra parte de la sedimentación de la cuenca de antepaís fracturado de Vinchina (Orogenia Andina) en el noroeste argentino. Esta unidad está compuesta por conglomerados, areniscas y pelitas junto con algunos niveles de brechas y tobas depositados principalmente en ambientes continentales. Once asociaciones de facies (AF) fueron reconocidas, ocho corresponden al miembro inferior y tres al superior. La AFI está compuesta por megabrechas intraformacionales y conglomerados depositados en ríos entrelazados gravosos que rellenaron el paleovalle fluvial en el norte del área. La AFII, formada por brechas intraformacionales y areniscas integrando fajas de canales fuertemente incisas dentro una planicie aluvial, fue identificada en las posiciones marginales del mencionado paleovalle. La AFIII, integrada por fajas de canales gravosos con planicies arenosas, corresponde a ríos anastomosados de clima semiárido que evolucionó a un sistema con espesas planicies fangosas con delgados desbordamientos arenosos y canales simples gravosos (AFIV). Por su parte, la AFV consiste de complejos de canales arenosos encapsulados con ciclos grano-crecientes. La AFVI está compuesta por conglomerados y areniscas guijarrosas depositadas en una planicie entrelazada que evoluciona a un sistema fluvial de menor energía (AFVII) caracterizado por un aumento de depósitos fangosos con lóbulos arenosos y lentes gravosas. La AFVIII está dominada por sedimentos finos depositados en un lago somero. En el miembro superior, la AFIX corresponde a un sistema fluvial entrelazado profundo gravoso. La AFX está compuesta por facies finas acumuladas en una planicie aluvial fuertemente agradante sobre la que progradan depósitos gruesos correspondiente a un piedemonte dominado por flujos canalizados (AFXI). En la evolución paleoambiental de la Formación Toro Negro se reconocen 3 etapas. La etapa I correspondiente a la formación de un paleovalle fluvial en el norte del área y posterior relleno por cursos fluviales gravo-arenosos provenientes del oeste principalmente (AFI-V). En la etapa II se desarrollan sistemas fluviales no confinados areno-gravosos (AFVI-VII) que progradan sobre un lago somero (AFVIII) desarrollado en el sur del área. Finalmente, la etapa III (miembro superior) corresponde a pulsos de progradación de la cuña clástica (AFIX-XI) desde el oeste (Precordillera).","palabras_clave":"ANTEPAIS|NEOGENO|TORO NEGRO|AMBIENTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89553,"idioma_id":4,"titulo":"Mechanism of electron transfer processes photoinduced by lumazine","resumen":"UV-A (320-400 nm) and UV-B (280-320 nm) radiation causes damage to DNA and other biomolecules through reactions induced by different endogenous or exogenous photosensitizers. Lumazines are heterocyclic compounds present in biological systems as biosynthetic precursors and\/or products of metabolic degradation. The parent and unsubstituted compound called lumazine (pteridine-2,4(1,3H)-dione; Lum) is able to act as photosensitizer through electron-transfer-initiated oxidations. To get further insight into the mechanisms involved, we have studied in detail the oxidation of 2&#8242;-deoxyadenosine 5&#8242;-monophosphate (dAMP) photosensitized by Lum in aqueous solution. After UV-A or UV-B excitation of Lum and formation of its triplet excited state (3Lum*), three reaction pathways compete for the deactivation of the latter: intersystem crossing to singlet ground state, energy transfer to O2, and electron transfer between dAMP and 3Lum* yielding the corresponding pair of radical ions (Lum?- and dAMP?+). In the following step, the electron transfer from Lum?- to O2 regenerates Lum and forms the superoxide anion (O2?-), which undergoes disproportionation into H2O2 and O2. Finally dAMP?+ participates in subsequent reactions to yield products.","palabras_clave":"LUMAZINE|ELECTRON TRANSFER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89554,"idioma_id":4,"titulo":"Product-Line Instantiation Guided By Subdomain Characterization: A Case Study","resumen":"Reuse-oriented software methodologies have  emerged to provide a set of rules or guides for  development and evolution of software systems by  reusing existing domain engineering artefacts such  as requirements, architecture, components, test cases,  etc. Domain engineering methods, such as software  product lines engineering, aim at reducing develop-  ment time, effort, cost, and complexity by taking  advantage of the commonality within a portfolio  of similar products. However, these methodologies  are not based on specific domains, instead they  cover a wide range of domains without considering  particularities within them. Therefore, in this work  we define a novel approach in which the creation  of a software product line is guided by a subdomain  analysis process, oriented to a particular case within  the marine ecology domain. The methodology is then  applied to a specific organization in order to create a  product of the line.","palabras_clave":"Open source|Product-line|Ecological domain"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89555,"idioma_id":4,"titulo":"17b-Estradiol modulates the prolactin secretion induced by TRH through membrane estrogen receptors via PI3K\/Akt in female rat anterior pituitary cell culture","resumen":"Considering that estradiol is a major modulator of prolactin (PRL) secretion, the aim of the present study was to analyze the role of membrane estradiol receptor-a(mERa) in the regulatory effect of this hormone on the PRL secretion induced by thyrotropin-releasing hormone (TRH) by focusing on the phosphatidylinositol 3-kinase (PI3K)\/protein kinase B (Akt) pathway activation. Anterior pituitary cell cultures from female rats were treated with 17b-estradiol (E2, 10 nM) and its membrane-impermeable conjugated estradiol (E2-BSA, 10 nM) alone or coincubated with TRH (10 nM) for 30 min, with PRL levels being determined by RIA. Although E2, E2-BSA, TRH, and E2\/TRH differentially increased the PRL secretion, the highest levels were achieved with E2-BSA\/TRH. ICI-182,780 did not modify the TRH-induced PRL release but significantly inhibited the PRL secretion promoted by E2 or E2-BSA alone or in coincubation with TRH. The PI3K inhibitors LY-294002 and wortmannin partially inhibited the PRL release induced by E2-BSA, TRH, and E2\/TRH and totally inhibited the PRL levels stimulated by E2-BSA\/TRH, suggesting that the mER mediated the cooperative effect of E2 on TRH-induced PRL release through the PI3K pathway. Also, the involvement of this kinase was supported by the translocation of its regulatory subunit p85a from the cytoplasm to the plasma membrane in the lactotroph cells treated with E2-BSA and TRH alone or in coincubation. A significant increase of phosphorylated Akt was induced by E2-BSA\/TRH. Finally, the changes of ERa expression in the plasmalemma of pituitary cells were examined by confocal microscopy and flow cytometry, which revealed that the mobilization of intracellular ERa to the plasma membrane of lactotroph cells was only induced by E2. These finding showed that E2 may act as a modulator of the secretory response of lactotrophs induced by TRH through mER, with the contribution by PI3K\/Akt pathway activation providing a new insight into the mechanisms underlying the nongenomic action of E2 in the pituitary. ","palabras_clave":"17B-ESTRADIOL|PRL SECRETION|MEMBRANE ESTROGEN RECEPTORS|LACTOTROPHS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89556,"idioma_id":4,"titulo":"A DFT study of dodecahedral beryllium silicide cage clusters","resumen":"Density functional theory calculations have been conducted on 20- and 32-atom dodecahedral and facecapped dodecahedral cage clusters of beryllium and silicon. Stable Be24Si8, Be12Si8 and Be12Si20 cages are described, as is a stuffed cluster consisting of dodecahedral Si20 with an endohedral icosahedral Be12. Especial stability is associated with clusters in which faces are capped by silicon atoms, acting as electron donors to beryllium atoms.&nbsp;  ","palabras_clave":"DFT|beryllium silicide | cage clusters"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89557,"idioma_id":4,"titulo":"Grid Matrix: a Grid Simulation Tool to Focus on the Propagation of Resource and Monitoring Information","resumen":"Grid Computing proposes unlimited access to different computational resources in a transparent way. High performance execution in grid environments is virtually impossible without timely access to accurate and up-to-date information related to distributed resources and services. Due to inherent difficulty of testing the different information propagation policies in real grid infrastructures, several simulation frameworks arose to help in this issue. In this work, we present Grid Matrix, an extension to one of the most used grid simulation tools (SimGrid2) to focus on the propagation of monitoring and resource information allowing the creation of virtual grid infrastructures. This extension enables GUI editing of network topology and provides the feature of scripting to define simulation details based on the newly developed C++ and Python bindings of SimGrid2 API. As a case study, Grid Matrix was used to test four different policies: hierarchical, super-peer, best-neighbor and random. The simulated scenario consisted of 96 master nodes based on the real Teragrid infrastructure as was publicly available at the time of writing this paper. We introduce three metrics that capture and summarize the information propagation behavior: LIR, GIR and GIV. LIR captures the local behavior quantifying the amount of up-to-date information in each node. GIR evaluates the global information state in the whole network averaging the LIR values, while GIV measures the variability of LIR. In the presented case, the best results in terms of the proposed metrics were attained by the hierarchical policy, followed by super-peer which outperformed random and best-neighbor. The modern and modular design of the scripting features included in Grid Matrix, in close conjunction with the user friendly GUI happened to be a very powerful tool for the evaluation of new propagation policies of resource information.","palabras_clave":"GRID COMPUTING|RESOURCE MONITORING|RESOURCE DISCOVERY|PROPAGATION POLICIES|SIMULATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89558,"idioma_id":4,"titulo":"Do not fear your opponent: sub-optimal changes of a prevention strategy when facing stronger opponents","resumen":"The time spent making a decision and its quality define a widely studied trade-off. Some models   suggest that the time spent is set to optimize reward, as verified empirically in simple-decision making   experiments. However, in a more complex perspective compromising components of regulation focus, ambitions,  fear, risk and social variables, adjustment of the speed-accuracy trade-off may not be optimal.   Specifically, regulatory focus theory shows that people can be set in a promotion mode, were focus is on seeking to approach   a desired state (to win), or in a prevention mode, focusing to avoid undesired states (not to lose).   In promotion people are eager to take risks increasing speed and decreasing accuracy. In prevention, strategic vigilance increases,    decreasing speed and improving accuracy.  When time and accuracy have to be compromised one can ask which of these two strategies optimizes reward, leading to optimal performance.   We investigate this  in a unique experimental environment. We study decision-making in  rapid-chess (180 seconds per game) in which the goal of a player is to mate   the opponent in a finite amount of time, or, alternatively, time-out of the opponent with   sufficient material to mate.  In different games, players face strong and weak opponents. We observe that: 1) players adopt a more conservative strategy  when facing strong opponents, with slower and more accurate moves; 2) this strategy is suboptimal: players   increase their winning likelihood against strong opponents using the policy they adopt when   confronting opponents with similar strength.","palabras_clave":"chess|adaptation|response time|decision making"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89559,"idioma_id":4,"titulo":"A quantitative philology of introspection","resumen":"The cultural evolution of introspective thought has been recognized to undergo a drastic change during the middle of the first millennium BC. This period, known as the ?Axial Age,? saw the birth of religions and philosophies still alive in modern culture, as well as the transition from orality to literacy?which led to the hypothesis of a link between introspection and literacy. Here we set out to examine the evolution of introspection in the Axial Age, studying the cultural record of the Greco-Roman and Judeo-Christian literary traditions. Using a statistical measure of semantic similarity, we identify a single ?arrow of time? in the Old and New Testaments of the Bible, and a more complex non-monotonic dynamics in the Greco-Roman tradition reflecting the rise and fall of the respective societies. A comparable analysis of the twentieth century cultural record shows a steady increase in the incidence of introspective topics, punctuated by abrupt declines during and preceding the First and Second World Wars. Our results show that (a) it is possible to devise a consistent metric to quantify the history of a high-level concept such as introspection, cementing the path for a new quantitative philology and (b) to the extent that it is captured in the cultural record, the increased ability of human thought for self-reflection that the Axial Age brought about is still heavily determined by societal contingencies beyond the orality-literacy nexus.","palabras_clave":"introspection|neuroscience|semantic cognition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89560,"idioma_id":4,"titulo":"The adjoint homology of a family of 2-step nilradicals","resumen":"We consider a family of parabolic subalgebras p of a simple Lie  algebra of type An and give a full description of the adjoint  homology of the nilradicals of p as a module over its Levi factor.  All the nilradicals considered are 2-step nilpotent.","palabras_clave":"LIE ALGEBRA|HOMOLOGY|NILRADICAL|PARABOLIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89561,"idioma_id":5,"titulo":"Determinación de la profundidad de juntura en celdas fotovoltaicas de  silicio monocristalino","resumen":"El presente trabajo tiene como objetivo desarrollar una metodología para la determinación en el laboratorio la profundidad de juntura de celdas fotovoltaicas. Para este fin se plantean dos métodos cuyos principios físicos difieren completamente. La aplicación de ambos métodos al mismo conjunto de muestras permite validar los resultados obtenidos mediante comparación. Como resultado de su aplicación se puede conocer la profundidad de junturas de las muestras elaboradas en el laboratorio con una precisión mejor al 10 %. Se concluye que ambas metodologías contribuyen a la caracterización de junturas p-n permitiendo mejorar las técnicas de dopado a través de ensayos de prueba y error. Por otro lado el material requerido es de uso común en cualquier laboratorio de sólidos y su implementación es de bajo costo.","palabras_clave":"CARACTERIZACION|ELECTROQUIMICA|ENERGIA SOLAR|SILICIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89562,"idioma_id":4,"titulo":"Growth Kinetics of Intermetallic Phases in Transient Liquid Phase Bonding Process (TLPB) in Al \/Ni System.","resumen":"New processes and materials are vital nowadays, since specific features of materials are  essential to accomplish the more demanding technological and environmental requirements. Al\/Ni  system has stimulated a large number of phase equilibrium, thermodynamic, diffusion and related  studies. Its relevance relays on first principle features as well as technological importance.  Transient Liquid Phase Bonding (TLPB) process is presented in this work due to the advantages of  this method above others. Low temperatures of processing are needed, to obtain stable intermetallic  phases (IPs) suitable for high temperatures of service. The aim of this research is to investigate the  impact of temperature on the IPs growth and formation mechanisms, completing previous works on  microstructure and kinetics characterization of IPs in Al\/Ni system at 720°C. The results of SEMEDS\/  WDS analyses of the cross-sections of the bonds showed the presence of Al3Ni and Al3Ni2 at  the beginning of the interaction between Al and Ni, which are consistent with the phase equilibrium  diagram. The Al3Ni2 layer growth showed linear correlation with time at 800°C, whereas at 900 and  1000°C it suggested a diffusive growth. Inert markers experiments allowed distinguishing  individual growth. Vickers micro-hardness was determined obtaining values for Ni and Al3Ni2 of  about 100 and 800 HV\/ 0.025, respectively.","palabras_clave":"NI-AL|INTERMETALLICS|TLPB|KINETICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89563,"idioma_id":4,"titulo":"Horizontal distribution of rotifers in a subtropical shallow lake (Paraná floodplain, Argentina)","resumen":"In water bodies where cladocerans are typically small or present in low biomass, such as in the tropics and subtropics of South America, rotifers may play a larger role in ecosystem functioning than in temperate lakes. The aim of this study was to analyze the horizontal distribution of richness and abundance of rotifers, their diel distribution patterns, and the relative importance of physical and biotic characteristics as their shaping factors, in a subtropical shallow vegetated lake of the Paraná River floodplain (Argentina). Three sampling stations were located along the major axis of the lake, one in open waters and two in littoral area dominated by the emergent Panicum elephantipes, Cyperus alternifolius and floating mats of the filamentous algae Cladophora spp. Two further stations were located on the transverse axis. Rotifer samples were taken on four occasions (at noon and midnight) during a five week period in the summer to avoid possible changes in the pattern of distribution of macrophytes and hydrological variability of the lake. Rotifer richness was higher in the littoral zone whereas rotifer abundance was higher in the limnetic zone. Some rotifers, such as Brachionus havanaensis and Keratella tropica exhibited changes in their diel horizontal distribution with higher concentrations of organisms at vegetated zones during the day time. In contrast, Polyarthra sp. were more abundant at night-time in both limnetic and littoral areas. The heterogeneous horizontal distribution of rotifers cannot be explained by the rather homogeneous distribution of both physical environmental factors and phytoplankton abundance. Rotifer distribution may be related to a complex of factors including the presence or absence of vegetation, the relatively uniform distribution of visual predators (fishes) and the heterogeneous distribution of non-visual predators (insects and shrimps).","palabras_clave":"vertebrate and invertebrate predators|cladocerans, ostracods|emergent macrophytes|diel horizontal distribution."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89564,"idioma_id":4,"titulo":"A simple approach to model SFRC","resumen":"Experimental research that shows the improvement in structural behavior of concrete with the addition  of fibers has been developed in the last years. Fibers control cracking and thus increase concrete toughness  and ductility. Much effort has been devoted in the last decade to model this material.  A simple homogenization approach based on a modified mixture theory is proposed in this paper to  model Steel Fiber Reinforced Concrete (SFRC). The proposed and calibrated model takes information from  the micro-scale to model the macro-scale. SFRC is considered as a composite material composed by concrete  matrix and fibers. Concrete is modeled with an elastoplastic model and steel fibers are considered as  orthotropic elastoplastic inclusions that can debond and slip from the matrix. In order to include this  inelastic phenomenon without explicitly modeling interface, constitutive equations of fibers are modified  including information from the debonding?slipping phenomena. The model requires concrete properties,  fibers material, geometry, distribution and orientation as input data. The fibers bond?slip behavior is  automatically derived from concrete properties and fibers geometry or it can be alternatively obtained  from pull out tests.  As illustration, the tension response of SFRC with different fiber contents is numerically simulated. The  model is verified with the results of bending tests of beams extracted from a SFRC slab that present different  fibers distribution due to the slab casting process. Comparisons with other numerical approaches  modeling SFRC as an equivalent homogeneous material are also included in the paper.","palabras_clave":"Steel Fiber Reinforced Concrete|Self compacting concrete|Pull-out|Flexure|Numerical model|Composite"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89565,"idioma_id":5,"titulo":"Diagnóstico preimplantatorio en biopsia de blastocisto  y transferencia en ciclo diferido","resumen":"Objetivo: Los adelantos en reprogenética han permitido el PGD en trofoectodermo equivalente al diagnostico en vellosidad coriónica. La mayor experiencia se tiene con biopsia en día+3. Si bien los resultados son satisfactorios tiene el inconveniente que el estudio se realiza en una o dos moléculas de ADn y si bien se acondicionan las técnicas para efectuar el estudio en células únicas, hasta en un 20% no se obtiene resultado. La biopsia en D+5 permite mayor numero de células y la obtención de resultados.material y método: Se presenta la experiencia de 62 ciclos realizados en 43 pacientes con transferencia diferida al ciclo estimulado. Los motivos fueron: afecciones monogénicas (15), translocaciones recíprocas (6), tipificado HLA (5), RHD(1), aneuploidías recurrentes (5) y PGSS (2). De los 62 ciclos iniciados, 61 fueron aspirados. De los aspirados, 17 (28%) no llegaron a blastocisto. Cuarenta y cinco ciclos (72%) llegaron a blastocisto, 29 de ellos de buena calidad (grupo I) y 16 de regular o mala calidad (grupo II).Resultados: Se lograron 12 embarazos de 26 transferencias hasta ahora efectuadas (46%), 11 en el grupo I (52%) y 1 en el II (20%). Los resultados hallados nos permitieron cambiar el anterior programa en D+3 y transferencia en fresco.","palabras_clave":"DIAGNOSTICO GENETICO PREIMPLANTATORIO|BIOPSIA DE BLASTOCISTO|TRANSFERENCIA EN CICLO DIFERIDO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89566,"idioma_id":5,"titulo":"La posición investigadora de los sistemas universitarios regionales a través de su producción científica","resumen":"Los indicadores sobre producción científica constituyen uno de los ejes clave de los rankings universitarios nacionales e internacionales. Dada la relevancia que estos rankings han adquirido en los últimos años, en este trabajo se realiza un análisis de la actividad investigadora del sistema universitario público español desglosado por CCAA. Se ofrece así una aproximación de conjunto a la potencia investigadora relativa de los sistemas universitarios regionales. Aunque es bien sabido que ninguna universidad española se posiciona entre las cien primeras en los rankings internacionales, la situación de nuestra producción científica ha mejorado notablemente en los últimos diez años. Sin embargo, las diferencias en actividad científica entre CC. AA. siguen siendo muy notorias. Mediante un análisis de las publicaciones científicas en bases de datos internacionales (producción, impacto, colaboración, visibilidad y orientación temática) se han analizado los factores que pueden estar detrás de estos resultados. Se ha podido apreciar que el tamaño económico de las CC. AA. está muy vinculado con el volumen de la producción. Se observa también que factores como la apertura a la colaboración internacional están muy relacionados con la visibilidad y el impacto. Los resultados generales muestran que las universidades públicas catalanas, como sistema universitario, en conjunto, presentan una situación muy ventajosa, lo que las posiciona como uno de los principales motores del sistema español de educación superior.","palabras_clave":"RANKINGS|INVESTIGACION|PRODUCCION CIENTIFICA|COMUNIDADES AUTONOMAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89567,"idioma_id":5,"titulo":"Revisión de la metodología utilizada para categorizar especies amenazadas de la herpetofauna Argentina","resumen":"Durante un taller para re-categorizar la herpetofauna de la Argentina realizado en el X Congreso Argentino de Herpetología de Jujuy (2009), se consensuó sobre la necesidad de revisar la metodología utilizada en Lavilla et al. (2000a), basada en Reca et al. (1994), con algunas modificaciones introducidas en cada grupo herpetológico (ver Avila et al., 2000; Lavilla et al., 2000b; Richard y Waller 2000; Scrocchi et al., 2000; Waller y Micucci 2000). Se conformó un grupo que comparó la metodología usada en 2000 con otras propuestas y discusiones publicadas (e.g. Grigera y Úbeda 2000a, 2002; UICN 2001, 2003, Gärdenfors et al., 2001; Díaz-Páez y Ortiz 2003; Sánchez et al., 2007; Úbeda y Grigera 2007; Giraudo et al., 2009, 2011).","palabras_clave":"Categorización|Método|Especies amenazadas|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89568,"idioma_id":4,"titulo":"Molecular Systematic of Three Species of Oithona (Copepoda, Cyclopoida) from the Atlantic Ocean: Comparative Analysis Using 28S rDNA","resumen":"Species of Oithona (Copepoda, Cyclopoida) are highly abundant, ecologically important, and widely distributed throughout the world oceans. Although there are valid and detailed descriptions of the species, routine species identifications remain challenging due to their small size, subtle morphological diagnostic traits, and the description of geographic forms or varieties. This study examined three species of Oithona (O. similis, O. atlantica and O. nana) occurring in the Argentine sector of the South Atlantic Ocean based on DNA sequence variation of a 575 base-pair region of 28S rDNA, with comparative analysis of these species from other North and South Atlantic regions. DNA sequence variation clearly resolved and discriminated the species, and revealed low levels of intraspecific variation among North and South Atlantic populations of each species. The 28S rDNA region was thus shown to provide an accurate and reliable means of identifying the species throughout the sampled domain. Analysis of 28S rDNA variation for additional species collected throughout the global ocean will be useful to accurately characterize biogeographical distributions of the species and to examine phylogenetic relationships among them.","palabras_clave":"Oithona helgolandica|O. nana|O. atlantica|28S rRNA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89569,"idioma_id":4,"titulo":"'Corrosion Susceptibility of Zn-Al Alloys with Different Grains and Dendritic Microstructures in NaCl Solutions'","resumen":"The objective of the present research was to study the corrosion susceptibility of different hypoeutectic and hypereutectic  zinc-aluminium alloys with different grains (columnar,  equiaxed and columnar-to-equiaxed transition, CET) and dendritic microstructures in 3 NaCl solution at  room temperature.  The corrosion resistance was analyzed by electrochemical impedance spectroscopy (EIS) as a principal  technique. The EIS results show that as the aluminium content increases the rate of formation of corrosion  products on the alloys also increases. These products appear to have protective features in the light  of the results of voltammograms.","palabras_clave":"Corrosion|Zn-Al alloys|EIS|Pitting corrosion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89570,"idioma_id":4,"titulo":"C band radiometric response to rainfall events in the subtropical Chaco forest","resumen":"In this letter, multitemporal signatures collected by Advanced Microwave Scanning Radiometer (AMSR-E) over the dry forest of Chaco, located in North Argentina, are analyzed. The forest has a biomass of about 100 t\/ha and a woody volume of about 120 m3\/ha. A clear increase of polarization index at C-band is observed after intense rain events in two different locations.Simulations of a discrete model attribute this effect to variations of soil moisture and predict an effect comparable with the measured one. Results indicate that there is a potential to monitor soil moisture variations below dry forests with moderate biomass, also in view of the forthcoming availability of L-band data.","palabras_clave":"Forest|Microwave radiometry|modeling|soil moisture"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89571,"idioma_id":4,"titulo":"Impact of starch gelatinization on the kinetics of maillard reaction in freeze-dried potato systems.","resumen":"The objective of the present work was to contribute to the understanding of the changes in water-distribution and water\u2013solids interactions that take place after starch gelatinization and to elucidate their influence on the kinetics of Maillard reaction in low-moisture potato starch systems. Maillard reaction was studied in freeze-dried native (NS) and gelatinized (GS) potato starch systems at 70°C. Water sorption isotherms were studied in a wide range of relative humidities (RH) and Guggenheim-Anderson-de Boer (GAB) model was applied. Thermal transitions were studied by differential scanning calorimetry; molecular mobility was estimated through time-resolved 1H NMR, and Maillard reaction was followed photocolorimetrically. In NS systems, the Maillard reaction rate was inversely dependent with the increase of RH. These results are due to a heterogeneous distribution of water and reactants within the starch matrix. In GS systems, the rate coefficient of the Maillard reaction increased up to RHs between 75% and 84% and then decreased at higher RH values. In this case, Maillard reaction rate could be related to the physical properties of the matrix: T g, water sorption, and water mobility can be relevant tools to predict the Maillard reaction rate-dependence on water content.","palabras_clave":"starch gelatinization|Maillard reaction|dehydrated potato|water activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89572,"idioma_id":4,"titulo":"Results of a self-triggered prototype system at the Pierre Auger Observatory for radio-detection of air showers induced by cosmic rays","resumen":"We describe the experimental setup and the results of RAuger, a small radio-antenna array, consisting of three fully autonomous and self-triggered radio-detection stations, installed close to the center of the Surface Detector (SD) of the Pierre Auger Observatory in Argentina. The setup has been designed for the detection of the electric field strength of air showers initiated by ultra-high energy cosmic rays, without using an auxiliary trigger from another detection system. Installed in December 2006, RAuger was terminated in May 2010 after 65 registered coincidences with the SD. The sky map in local angular coordinates (i.e., zenith and azimuth angles) of these events reveals a strong azimuthal asymmetry which is in agreement with a mechanism dominated by a geomagnetic emission process. The correlation between the electric field and the energy of the primary cosmic ray is presented for the first time, in an energy range covering two orders of magnitude between 0.1 EeV and 10 EeV. It is demonstrated that this setup is relatively more sensitive to inclined showers, with respect to the SD. In addition to these results, which underline the potential of the radio-detection technique, important information about the general behavior of self-triggering radio-detection systems has been obtained. In particular, we will discuss radio self-triggering under varying local electric-field conditions.","palabras_clave":"UHECR Cosmic Rays |Pierre Auger Observatory"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89573,"idioma_id":4,"titulo":"Lectin histochemical aspects of the ovarian lamellae epithelium of Genypterus blacodes (Schneider, 1801)","resumen":"The composition and distribution of the glycoconjugates (GCs) secreted by the epithelium of ovarian lamellae with reference to the reproductive biology of Genypterus blacodes (Schneider, 1801) through lectin histochemistry is here discussed. In this species, the epithelialcells that line the ovarian c avity presented sharp morphological variations along the reproductive cycle related to the mucus secretion that accompanies oocyte maturation. During spawning season, residues of mannose and N-acetylglucosamine were detected in the glycocalyx of those cells using lectinhistochemistry. N-acetylgalactosamine and fucosewere also observed in the same zone. The greatest variations in the lectinhistochemical pattern were found in the apical cytoplasm composition in comparison to the basal zone of the cells. The results of the present study were discussed by comparing their possiblefunctional implications.","palabras_clave":"GENYPTERUS|GLYCOCONJUGATES|LECTINS|HISTOCHEMISTRY|OVARY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89574,"idioma_id":4,"titulo":"Genetic variability for responses to short and long term salt stress in vegetative sunflower plants","resumen":"Sunflower (Helianthus annuus L.) has been rated as moderately salt-resistant, and variability for salt resistance has been detected within this crop. However, variability in salt-resistancemechanisms has not been assessed. Osmotic tolerance, the relation of salt resistance withwhole-plant Na+ and K+ distribution and tissue Na+ tolerance were investigated in several sunflower inbred lines. Plants were grown under controlled conditions, in pots with sand and perlite irrigated with salinized (NaCl, ?0.65 MPa) nutrient solution. Osmotic tolerance was assessed from the initial effects of the salt treatment on plant elongation in eleven sunflower lines. Longterm salinity responses were evaluated in four of those lines, by assessing whole-plant growth. A principal components analysis (PCA) was run on relative-to-control growth data, and this information was used to establish a relative resistance ranking, which indicated lines HAR2 &gt; HAR1&gt; HA64 &gt; HAR5. Osmotic tolerance was observed in HA64 and HAR2. The lines showed different degrees of Na+ accumulation, it was very low in some of them, but relative salt resistance was not associated to this trait. Tissue Na+ tolerance was deduced by comparing the percentage of dead leaves as a function of leaf blade Na+ accumulation, and it was higher in HAR1 than in the rest. These results indicate that variability for salt-resistance mechanisms exists in sunflower. Osmotic tolerance and tissue Na+ tolerance were detected in different lines, highlighting that such variability may be exploited for increasing salt resistance in this crop.","palabras_clave":"HELIANTHUS ANNUUS|OSMOTIC TOLERANCE|SALINITY|NA+ TISSUE TOLERANCE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89575,"idioma_id":5,"titulo":"MATERIALES DE OBTURACIÓN UTILIZADOS EN LA TERAPIA ENDODÓNTICA EN DIENTES PRIMARIOS.","resumen":"El objetivo de este estudio longitudinal fue evaluar clinica y radiograficamente el exito, a los 6 y 12 meses, de diferentes pastas de relleno en molares primarios sometidos a pulpectomias. Cincuenta y cuatro molares primarios de 47 niños (edad promedio 5.8 ± 1.2 años) fueron distribuidos aleatoriamente a los siguientes grupos: OZinc Eugenol (OZE), iodoformo\/Glicerina (IG), Vitapex, Pasta de Guedes Pintos. El tratamiento se considero exitoso ante la presencia de un diente asintomatico y radiograficamente se observo una disminucion o ausencia de cambios en el defecto radiolucido patologico preexistente. l exito total fue del 91%, no demostrandose diferencias significativas entre el exito clinico (p&#8804; 0.2069 vs p&#8804;0.1110) y radiografico (p&#8804;0.3113 vs p&#8804;0.3220) alos6 meses y 12 meses. A los 12 meses el Vitapex mantuvo el 100% de las piezas, seguido por la de IG con 93%, Pasta de Guedes con 86% y OZE con 83%.  Conclusion: Si biien todas las pastas de relleno demostraron serefectivas, aquellas conteniendo materiales iodoformadosbfueron ligeramente superiores a la pasta de guedes y el OZE al permitir la permanencia de los molares primarios asintomaticos tanto en la clinica como radiograficamente a los 12 meses.","palabras_clave":"Necrosis Pulpar|Pulpectomias|Denticion Primaria|Pastas Endodonticas"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89576,"idioma_id":4,"titulo":"USE OF PROSTAGLANDIN F2&#945; IN POSTPARTUM DAIRY COWS AND ITS EFFECT ON SUBCLINICAL ENDOMETRITIS","resumen":"Subclinical endometritis (SE) decreases reproductive efficiency in  dairy cows. The prevention and treatment of this pathology is important  for improving the reproductive and productive performance  of dairy cattle. Several authors described the use of prostaglandin  F2&#945; or its analogues, based on the effective results on clinical endometritis,  for SE. The aim of this work was to evaluate whether  the use of PGF2&#945; in postpartum reduces the presence of SE. Were  examined 271 Holstein dairy cows between 21-56 days in milk  (DIM), of 6 farms in the southern Santa Fe. Two of them using 2  applications postpartum of PGF2&#945;, at 30 DIM and other at 45 DIM  (with PGF2&#945;). Farms remaining do not use of PGF2&#945; (without  PGF2&#945;). To calculate the % of neutrophils were used endometrial  samples obtained by cytobrush. Cows in ?healthy? (without SE)  and ?SE+? (with SE), were grouped.  Was applied Fisher test. There were no significant differences  (P<0.3095) on the presence of SE between groups. We concluded  that use of PGF2&#945; in postpartum, not decreases SE, in relation to  farms that do not use. It required further studies of therapeutic  measures for the control and treatment of SE.","palabras_clave":"dairy cows|subclinical endometritis|reproductive efficiency|prostaglandin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89577,"idioma_id":4,"titulo":"Quantification of Autoantibodies to Annexin V in Plasma by an  \u201CIn House\u201D Sandwich ELISA","resumen":"An 'in house' sandwich ELISA for the quantification of plasma anti-annexin V antibodies was developed and validated. The validation parameters studied were: (i) precision, expressed either as the intra- or the inter-assay coefficient of variation (CV), (ii) exactitude, expressed as the percentage deviation between the obtained value and the real value, (iii) limit of detection (LOD), evaluated from the reagents blank and (iv) robustness, obtained by deliberately introducing slight variations in different parameters. Also, a comparison between the 'in house' technique and a commercial method was performed. The research revealed that both CV were &lt; 20%, exactitude was within the 100 ± 20% range, limit of detection was below 1 U mL-1 and that slight variations in the technique did not produce any significant variations in the results. Comparison with the commercial method showed an acceptable correlation. It was concluded that the method developed here satisfactorily accomplishes the parameters of standardization and validation for an immunoassay.","palabras_clave":"ELISA|ANNEXIN V|ANTIBODIES|ANTI-PHOSPHOLIPID SYNDROME"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89578,"idioma_id":4,"titulo":"Identifi cation of growth-dependent transcripts in the haloalkaliphilic archaeon Natrialba magadii","resumen":"Analysis of gene expression at the transcriptional level helps to explore the physiological significance of gene products. In this study we have used RAP-PCR to identify genes differentially regulated in response to the transition from the exponential to the stationary phase in the dual extremophilic haloarchaeon Natrialba magadii ATCC 43099 (optimum growth in 3.5 M NaCl and pH 10). ","palabras_clave":"ABC transporter|gene expression|HIT protein|Natrialba magadii|stationary phase"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89579,"idioma_id":4,"titulo":"Autocatalytic maturation of the Tat-dependent halophilic subtilase Nep produced by the archaeon Natrialba magadii","resumen":"Halolysins are subtilisin-like extracellular proteases produced by haloarchaea that possess unique protein domains and are salt dependent for structural integrity and functionality. In contrast to bacterial subtilases, the maturation mechanism of halolysins has not been addressed. The halolysin Nep is secreted by the alkaliphilic haloarchaeon Natrialba magadii, and the recombinant active enzyme has been synthesized in Haloferax volcanii. Nep contains an N-terminal signal peptide with the typical Tat consensus motif (GRRSVL), an N-terminal propeptide, the protease domain, and a C-terminal domain. In this study, we used Nep as a model protease to examine the secretion and maturation of halolysins by using genetic and biochemical approaches. Mutant variants of Nep were constructed by site-directed mutagenesis and expressed in H. volcanii, which were then analyzed by protease activity and Western blotting. The Tat dependence of Nep secretion was demonstrated in Nep RR\/KK variants containing double lysine (KK) in place of the twin arginines (RR), in which Nep remained cell associated and the extracellular activity was undetectable. High-molecular-mass Nep polypeptides without protease activity were detected as cell associated and extracellularly in the Nep S\/A variant, in which the catalytic serine 352 had been changed by alanine, indicating that Nep protease activity was needed for precursor processing and activation. Nep NSN 1-2 containing a modification in two potential cleavage sites for signal peptidase I (ASA) was not efficiently processed and activated. This study examined for the first time the secretion and maturation of a Tat-dependent halophilic subtilase.","palabras_clave":"natrialba magadii|subtilisin|protease maturation|NEP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89580,"idioma_id":4,"titulo":"Evaluating uncertainties in regional climate simulations over South America at the seasonal scale","resumen":"This work focuses on the evaluation of different sources of uncertainty affecting regional climate simulations over South America at the seasonal scale, using the MM5 model. The simulations cover a 3-month period for the austral spring season. Several four-member ensembles were performed in order to quantify the uncertainty due to: the internal variability; the definition of the regional model domain; the choice of physical parameterizations and the selection of physical parameters within a particular cumulus scheme. The uncertainty was measured by means of the spread among individual members of each ensemble during the integration period. Results show that the internal variability, triggered by differences in the initial conditions, represents the lowest level of uncertainty for every variable analyzed. The geographic distribution of the spread among ensemble members depends on the variable: for precipitation and temperature the largest spread is found over tropical South America while for the mean sea level pressure the largest spread is located over the southeastern Atlantic Ocean, where large synoptic-scale activity occurs. Using nudging techniques to ingest the boundary conditions reduces dramatically the internal variability. The uncertainty due to the domain choice displays a similar spatial pattern compared with the internal variability, except for the mean sea level pressure field, though its magnitude is larger all over the model domain for every variable. The largest spread among ensemble members is found for the ensemble in which different combinations of physical parameterizations are selected. The perturbed physics ensemble produces a level of uncertainty slightly larger than the internal variability. This &nbsp;study suggests that no matter what the source of uncertainty is, the geographical distribution of the spread among members of the ensembles is invariant, particularly for precipitation and temperature . ","palabras_clave":"REGIONAL CLIMATE MODELING|SOUTH AMERICA|UNCERTAINTY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89581,"idioma_id":4,"titulo":"STUDY OF THE ELECTRON TRANSFER PROPERTIES OF NANOSTRUCTURED BIMETALLIC FILMS OF POLYMERIZED PORPHYRINS","resumen":"The amperometric response of gold electrodes modified with bimetallic films of metalloporphyrins (FeCuPP) to H2O2 is dramatically higher than the corresponding to the bare electrode (up to 60 times) and far exceeding the individual CuPP or FePP. This response is attributed to the incorporation of H2O2 as ligand of both metal centers. Polymeric mono and bimetallic porphyrins doped with multiwalled car-bon nanotubes were studied by EIS and voltammetry to understand the differential response. A better electron transfer rate was observed in the composites allowing the study of the effect of ligands on the electrochemical response. The cyclic voltammetry showed a reversible wave for azide reduction only with the bimetallic composite. The EIS experiment showed two different RC time constants suggesting that H2O2 and azide intercalate as linking the metal centres. The anion nitrite inhibits these differences and does not affect the monometallic structures. Polymers deposited onto gold electrodes reveal an amorphous structure by SEM micrograph, whereas the corresponding composites prepared by electro-co-deposition present a network of interconnected fibrils with diameters similar to the nanotubes serving as backbones of the porphyrin aggregates. ","palabras_clave":"BIMETALLIC PORPHYRINS|NANOTUBES|EIS|VOLTAMMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89582,"idioma_id":4,"titulo":"Variation of morphological and chemical traits of perennial grasses in arid ecosystems. Are these patterns influenced by the relative abundance of shrubs?","resumen":"We asked whether morphological and chemical traits of perennial grasses in semiarid-arid ecosystems are influenced by the abundance of coexisting shrubs, in northern-central Patagonia, Chubut Province, Argentina. We selected populations of two perennial grass species, highly preferred by herbivores (4 for Festuca pallescens and 8 for Poa ligularis) at 10 sites distributed across a wide range of aridity.We assessed the relative shrub cover (shrub cover as percent of total cover) of each site and randomly collected 5 to 10bunches of each grass species per site in December 2007 (late vegetative-early reproductive growth period). We measured the height of vegetative tillers, and morphological (length, width, area, dry mass, and specific area) and chemical (N, C, soluble phenolics and lignin concentration) attributes of full expanded green blades in the collected bunches. Further, we computed the aridity index of each site using temperature and precipitation data. The aridity index ranged from 1.07 to 3.9 at F. pallescens sites and from 3.6 to 7.3 at P. ligularis sites. The relative shrub cover increased significantly with aridity varying from 0.01 to 99%. Tiller height, blade length, and blade area of P. ligularis increased significantly with increasing relative shrub cover and aridity. Concentration of soluble phenolics in blades of both species decreased with increasing relative shrub cover and aridity. N concentration in blades of P. ligularis and specific blade area in F. pallescens decreased with increasing relative shrub cover and aridity. We conclude that some traits of perennial grasses (phenolics concentration in green blades in both species, and tiller height and some blade attributes in P. ligularis) were influenced by shrub cover itself. The variation in these traits was opposite to that expected by the effect of aridity and could be associated with escape from herbivores and\/or drought, enhanced mesophytism, and reduced chemical defenses.","palabras_clave":"DEFENSES|DROUGHT|HERBIVORY|LEAF SIZE|MESOPHYTIC TRAITS|NITROGEN|PATAGONIA|SOLUBLE PHENOLICS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89583,"idioma_id":4,"titulo":"- Effects of the AMP-activated protein kinase inhibitor compound C on the postconditioned rat heart.","resumen":"Ischemic postconditioning (IPOC) protects the myocardium from ischemic-reperfusion injury, improving functional recovery and cell viability. This protection is concurrent with stimulation of glycogen breakdown, increased mitochondrial ATP synthesis and content, maintenance of reduced-to-oxidized glutathione ratio (GSH\/GSSG), and decreased oxidative damage. The present study´s objective was to assess whether these effects are associated with increased resistance to mitochondrial permeability transition pore (MPTP) opening. The effects of the AMP-activated protein kinase (AMPK) inhibitor, compound C (CC), were measured to investigate association with AMPK. Mitochondria removed from postconditioned hearts required higher calcium levels to induce MPTP opening. Improved functional recovery, increased glycogen mobilization, maintenance of the GSH\/GSSG ratio, decreased oxidative damage, and increased resistance to MPTP opening were abrogated when the hearts were postconditioned in the presence of CC, without affecting preservation of cell viability. Although AMPK appears to play a role in IPOC, it would not be the major cellular mediator.","palabras_clave":"ischemia|postconditioning|heart|compound C"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89584,"idioma_id":4,"titulo":"Heat transfer in a short parallel plate channel in the transition regime","resumen":"Heat transfer in a parallel-plate channel with uniform wall heat flux and refrigerated by water is investigated experimentally for the laminar and transition hydrodynamic regimes. The dimensions of the channel were chosen such that entry effects are relevant for a significant part of the channel length. The influence of the following parameters has been studied: inlet Reynolds number, inlet temperature and wall heat flux. Experimental results are compared with predictions based on different empirical correlations for convection in ducts. This analysis shows that the correlation of Gnielinski provides a good agreement with the experimental results for Reynolds numbers between 5,000 and 10,000 at 20°C and under relatively low heat fluxes. Experiments performed at relatively low heat fluxes show that, in the entry region previous to the laminar-turbulent transition, the behavior of the flow is well described by the combined hydrodynamic and thermal entry solution obtained by Hwang and Fan (Finite Difference Analysis of Forced-Convection Heat Transfer in Inlet Region of a Flat Rectangular Duct, Appl. Sci. Res., vol. 13, pp. 401\u2013422, 1964). The hydrodynamic and thermal entry effects for the experimental conditions in the present work are relevant for most of the test section. The location of the transition point is affected in the first instance by the local bulk Reynolds. On the other hand, the wall heat flux affects the fluid properties, i.e., the fluid viscosity, and therefore, it also affects the transition. It was found that for the transition regime, an increase of the wall heat flux produces lower values of the convection coefficient than the values predicted by the correlation of Gnielinski. This behavior, which seems to be associated to the variation of the fluid properties, is opposite to the increase of the convection coefficient observed for heating in the laminar and turbulent regimes for water and oils. The case of an inlet Reynolds number of 5,000 was studied in detail, and the influence of heat flux on the Nusselt number is addressed.","palabras_clave":"PARALLEL-PLATE CHANNEL|HYDRODYNAMIC TRANSITION|HEAT TRANSFER|HIGH HEAT FLUX|VARIABLE PROPPERTIES|FORCED CONVECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89585,"idioma_id":4,"titulo":"Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.","resumen":"Tumor microenvironment is composed of different cell types including immune cells. Far from acting to eradicate cancer cells,  these bone marrow-derived components could be involved in carcinogenesis and\/or tumor invasion and metastasis. Here, we  describe an alternative approach to treat solid tumors based on the genetic modification of hematopoietic stem and progenitor  cells with lentiviral vectors. To achieve transgene expression in derivative tumor infiltrating leukocytes and to try to decrease  systemic toxicity, we used the stress inducible human HSP70B promoter. Functionality of the promoter was characterized  in vitro using hyperthermia. Antitumor efficacy was assessed by ex vivo genetic modification of lineage-negative cells with  lentiviral vectors encoding the dominant-negative mutant of the human transforming growth factor-b receptor II (TbRIIDN)  driven by the HSP70B promoter, and reinfusion of cells into recipient mice. Subsequently, syngeneic GL261 glioma cells were  subcutaneously injected into bone marrow-transplanted mice. As a result, a massive antitumor response was observed in mice  harboring TbRIIDN under the HSP70B promoter, without the need of any external source of stress. In summary, this study  shows that stem cell-based gene therapy in combination with spatial and temporal control of transgene expression in  derivative tumor-infiltrating cells represents an alternative strategy for the development of novel antitumor therapies.","palabras_clave":"Células madre hematopoyéticas|infiltrado inflamatorio|promotor inducible|terapia antitumoral"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89586,"idioma_id":4,"titulo":"Oxygen Evolution Nickel Hydroxide Electrodes in a Ni-MH Battery Prototype","resumen":"The effect of cobalt in both alpha and beta phases on the oxygen evolution of nickel hydroxide was studied. The electrochemi-cal properties of the oxygen evolution reaction on the positive nickel hydroxide electrodes were studied under conditions similar to those of a commercial Ni-MH battery. The presence of different kinds of defects in the structure of the active material was determined by XRD methods distorted and asymmetric reflections in the XRD patterns. Both the morphology of the active material and the additives influence the oxygen evolution potential and the electrochemical characteristics. The experimental results showed that the optimized prototype used in this work is suitable for evaluating several electrochemical parameters. It was shown that the electrode without cobalt exhibited the charging efficiency was 94% and those with cobalt exhibited a charging of 98%.","palabras_clave":"NICKEL HYDROXIDE|OXYGEN|Ni-MH PROTOTYPE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89587,"idioma_id":4,"titulo":"Electrochemical effect of carbon nanospheres on an AB5 alloy","resumen":"In this paper, the effect of the addition of carbon nanospheres (CNE) by high energy mechanical milling to the active material of the negative electrode of a NickeleMetal Hydride (NieMH) battery is studied. The hydrogen storage alloy (MH) is an AB5-type (Lm0.95Ni3.8Co0.3Mn0.3Al0.4), where Lm is a mixture of rare earths, and it was prepared by melting the constituent elements in an electric induction furnace. The CNE were synthesized by two-stage polymerization of furfuryl alcohol, drying and carbonization, and were subsequently doped with different proportions of Ni (0e20%) by the method of wet impregnation with Nickel nitrate hexahydrate. The behavior of electrochemical cells consisting of a working electrode with 45% of MH, 5% of CNE pure and doped with different  proportions of Ni and 50% carbon Teflon acting as electrical and mechanical support, a counter electrode of Ni mesh, and a reference electrode Hg\/HgO was studied. The experiments covered electrochemical activation and cycle stability, rate capability and electrochemical impedance spectroscopy. The results show that the addition of CNE improves the electrochemical performance, and particularly the CNEs pure and doped with 20% of Ni present the best electrochemical performance in discharge capacity, rate capability and impedance spectroscopy.","palabras_clave":"Ni-MH batteries|AB5 alloy|Carbon nanospheres|Ni-doped"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89588,"idioma_id":4,"titulo":"Epicuticular hydrocarbons of the sugarcane borer Diatraea saccharalis (Lepidoptera: Crambidae)","resumen":"The epicuticular hydrocarbons of the larval, pupal and adult stages of the sugarcane borer Diatraea saccharalis Fabricius (Lepidoptera: Crambidae)are analyzed. Dramatic changes are observed between the stages studied. Adult hydrocarbons are mostly saturated, with a predominance of 1?4 methyl-branched straight carbon skeletons of 37?47 atoms; the major components are isomeric mixtures of internally branched trimethylderivatives of C39, C37 and C41 carbon backbones. By contrast, very small amounts of methyl-branched components are detected in the pupae, although straight chain hydrocarbons of 23?35 carbons are the prevailing structures (70.7 ± 3.4%) with n-C29 and n-C27 as the major components. Unsaturated hydrocarbons (29.0 ± 3.5%) of similar chain lengths elute by gas chromatography of epicuticular extracts as complex mixtures of mono-, di- and trienes; with the degree of unsaturation increasing with chain length. This is the first report of very long chain  unsaturated hydrocarbons in cuticular extracts of a larval lepidopteran (93.3 ± 0.6% of the lipid components), with chain lengths in the range 37?53 carbons and up to four double bonds; the major component being C49:3, which co-elutes with C49:4 and C49:2.","palabras_clave":"DEVELOPMENTAL STAGES|EPICUTICLE|HYDROCARBONS|LEPIDOPTERA|MASS SPECTROMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89589,"idioma_id":4,"titulo":"In vitro comparative analysis of antiproliferative activity of  essential oil from mandarin peel and its principal  component limonene","resumen":"Abstract   The effects of the essential oil of mandarin peel (Corrientes, Argentina) and limonene (its major component) were studied on two human tumour cell lines growth (lung adenocarcinoma A549 and hepatocarcinoma HepG2). The essential oil was obtained by cold press and its composition was investigated by gas chromatography (GC) and GC\/mass spectrometry (MS) analysis. The anti-proliferative effect was studied using an MTT assay. Both mandarin essential oil and limonene tested showed a strong dose-dependent effect on the growth inhibition of these cell lines. The essential oil was more effective in A549 than in HepG2 cells and more effective than limonene in both the cases. It is likely that  minor components and limonene of the oil could exert additive or synergistic effects. Hence, mandarin essential oil could lead to the development of anti-tumour agent or complementary and alternative medicines for the treatment of diverse cancers.","palabras_clave":"MANDARIN ESSENCIAL OIL|LIMONENE|HEPG2|A549"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89590,"idioma_id":4,"titulo":"The role of  asynapsis in human spermatocyte failure","resumen":"The basic molecular mechanisms by which chromosomal rearrangements in heterozygous state produce spermatogenic disturbances are poorly understood. Testicular biopsies from five patients - one carrier of a Robertsonian translocation rob t(13;14), two carriers of two different Y-autosome translocations, a t(Y;6) and a t(Y;11), one carrier of a reciprocal translocation t(3;13) and one carrier of a heterochromatin duplication in chromosome 9 - were processed for histopathological analysis, electron microscopy and fluorescent immunolocalization of meiotic proteins. In all the patients, the asynaptic regions during pachytene are labelled by BRCA1 and retained RAD51 foci. The variant histone &#947;-H2AX is located on the chromatin domains of the asynaptic regions and the XY body. In contrast, these meiotic proteins are absent in those chromosomal segments that are non-homologously synapsed. The present observations on five new cases and a review of recent studies show that the common features shared by all these cases are the abnormal location of some meiotic proteins and the presence of transcriptionally silenced chromatin domains on asynaptic regions. The frequent association of these silenced regions with the XY body and the rescue of spermatocyte viability through non-homologous synapsis are also shared by all these carriers. A passive, random mechanism of clustering of asynaptic regions with the XY body is suggested.","palabras_clave":"ASYNAPSIS|CHROMOSOMAL ABNORMALITIES|HUMAN|INFERTILITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89591,"idioma_id":5,"titulo":"EVALUACIÓN DEL ESTADO TRÓFICO DE DOS LAGUNAS PAMPEANAS (ARGENTINA)","resumen":"El principal objetivo de este estudio fue evaluar el estado trófico, describir la concentración de nutrientes y algunas variables ambientales en las lagunas Unamuno y Calderón (provincia de Buenos Aires, Argentina) durante tres y dos años, respectivamente. Las concentraciones de nitratos, nitritos, fosfatos, silicatos, materia orgánica particulada y clorofila ?a? fueron determinadas en laboratorio a partir de muestras de agua superficial. Los parámetros físicos fueron medidos in situ y los morfométricos fueron estimados a partir de imágenes satelitales. La calidad del agua de las lagunas fue determinada a partir de su estado trófico. Este último, fue estimado de acuerdo al índice de Carlson sobre la base de valores de clorofila ?a?. A lo largo del periodo estudiado, se caracterizó a las lagunas Unamuno y Calderón como oligohalina y mesohalina, respectivamente. Las concentraciones de fosfatos fueron altas en ambas lagunas, en comparación con los valores hallados en otras lagunas pampeanas. Las concentraciones de amonio y nitrato fueron predominantes en relación a los nitritos. De acuerdo a su estado trófico, la calidad de agua deninguna de las dos lagunas es aceptable para producción de agua potable y natación.","palabras_clave":"Imágenes satelitales|nutrientes|calidad del agua|lagos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89592,"idioma_id":4,"titulo":"SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity","resumen":"Serine protease inhibitor Kazal-type (SPINK3)\/P12\/PSTI-II is a small secretory protein from mouse seminal vesicle which contains a KAZAL domain and shows calcium (Ca2+)-transport inhibitory (caltrin) activity. This molecule was obtained as a recombinant protein and its effect on capacitated sperm cells was examined. SPINK3 inhibited trypsin activity in vitro while the fusion protein GST-SPINK3 had no effect on this enzyme activity. The inactive GST-SPINK3 significantly reduced the percentage of spermatozoa positively stained for nitric oxide (NO) with the specific probe DAF-FM DA and NO concentration measured by Griess method in capacitated mouse sperm; the same effect was observed when sperm were capacitated under low Ca2+ concentration, using either intracellular (BAPTA-AM) or extracellular Ca2+ (EDTA) chelators. The percentage of sperm showing spontaneous and progesterone-induced acrosomal reaction was significantly lower in the presence of GST-SPINK3 compared to untreated capacitated spermatozoa. Interestingly, this decrease was overcome by the exogenous addition of the NO donors, sodium nitroprusside (SNP), and S-nitrosoglutathione (GSNO). Phosphorylation of sperm proteins in tyrosine residues was partially affected by GST-SPINK3, however, only GSNO was able to reverse this effect. Sperm progressive motility was not significantly diminished by GST-SPINK3 or BAPTA-AM but enhanced by the addition of SNP. This is the first report that demonstrates that SPINK3 modulates sperm physiology through a downstream reduction of endogenous NO concentration and independently of SPINK3 trypsin inhibitory activity.","palabras_clave":"SpinkII|NO|protease inhibitors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89593,"idioma_id":4,"titulo":"A genetic approach to the species problem in wild potato","resumen":"Wild potatoes are native to the Americas, where they present very wide geographical and ecological distribution. Most are diploid, obligate out-crossers due to a multiallelic gametophytic self-incompatibility (S) locus that prevents self-fertilisation and crossing between individuals carrying identical S-alleles. They have two alternative modes of reproduction: sexual (by seeds) and asexual (by stolons and tubers), which provide, respectively, for genetic flexibility in changing environments and high fitness of adapted genotypes under stable conditions. Since the early twentieth century, their taxonomic classification has been mostly based on morphological phenotypes (Taxonomic Species Concept). More recently, attempts have been made to establish phylogenetic relationships, applying molecular tools in samples of populations (accessions) with a previously assigned specific category. However, neither the reproductive biology and breeding relations among spontaneous populations nor the morphological and genetic variability expected in obligate allogamous populations are considered when the taxonomic species concept is applied. In nature, wild potato populations are isolated through external and internal hybridisation barriers; the latter, which are genetically determined, can be either pre-zygotic (pollen-pistil incompatibility) or post-zygotic (abortion of embryo, endosperm or both tissues, sterility, and hybrid weakness and breakdown in segregating generations). The internal barriers, however, can be incomplete, providing opportunities for hybridisation and introgression within and between populations and ploidy levels in areas of overlap. The widespread occurrence of spontaneous hybrids in nature was recognised in the mid-twentieth century. Using genetic approaches, results have been obtained that provide strong support to the assertion that populations are at different stages of genetic divergence and are not at the end of the evolutionary process, as presupposed by the Taxonomic Species Concept. Furthermore, since wild potatoes have uniparental and biparental overlapping generations, the Biological Species Concept - developed for sexually reproducing biparental organisms - cannot be applied to them. In this paper, morphological, genetic, molecular and taxonomic studies in wild potato are reviewed, considering the genetic consequences of their reproductive biology, in an attempt to shed light on the species problem, because of its relevance in germplasm conservation and breeding.","palabras_clave":"SPECIES|HYBRIDIZATION|PROBLEM|TAXONOMIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89594,"idioma_id":4,"titulo":"OKB, a novel family of brain-gut neuropeptides from insects","resumen":"In insects, neuropeptides play a central role in the control of most physiological processes. The knowledge and characterization of new neuropeptide families, is of interest on the fields of Genetics, Genomics, Neurobiology, Endocrinology and Evolution. This knowledge also provides the tools for the design of peptidomimetics, pseudopeptides or small molecules, capable of disrupting the physiological processes regulated by the signaling molecules and their receptors. This is a promising target for a novel generation of insecticides. Using database searches, mass spectrometry and RACE-PCR, we identified a neuropeptide precursor transcript encoding a new family of insect neuropeptides in the hemipteran Rhodnius prolixus. We named this precursor Orcokinin B, because is originated by the alternative splicing of the Orcokinin gen. EST and genomic data suggests that Orcokinin B is expressed in the nervous system and gut from several insect species, with the exception of Drosophila sp. (Diptera) and Acyirthosiphon pisum (Hemiptera). Mass spectrometry and RT-PCR confirmed the expression of Orcokinin B in brain and anterior midgut of R.&nbsp;prolixus. Furthermore, we identified orthologues of this new family of peptides in genomic and EST databases from Arachnids and Crustaceans.","palabras_clave":"neuropeptidos|OKB|Rhodnius"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89595,"idioma_id":4,"titulo":"Identification of a point mutation associated with pyrethroid resistance in the para -type sodium channel of Triatoma infestans, a vector of Chagas disease","resumen":"The voltage-gated sodium channel is the target site of pyrethroid insecticides. Point mutations in thedomain II region of the channel have been implicated in pyrethroid resistance of several insect species.We identified the sequence of domain II from the para sodium channel in Rhodnius prolixus, a vector ofChagas? disease. With this information, we cloned and sequenced the domain II of the sodium channelfrom the other main Chagas? disease vector: Triatoma infestans. We also identified the presence of aresistance-conferring mutation (L1014F) in a pyrethroid-resistant population of T. infestans fromArgentina, and present a PCR-based method to detect this mutation in individuals from field populations.These findings have important implications for the implementation of strategies for resistance management,and for the rational design of campaigns for the control of Chagas? disease transmission.","palabras_clave":"TRIATOMA INFESTANS|RHODNIUS PROLIXUS|SODIUM CHANNEL GENE|CHAGA´S DISEASE.| PYRETHROID RESISTANCE| KDR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89596,"idioma_id":4,"titulo":"Cap binding-independent recruitment of eIF4E to cytoplasmic foci","resumen":"Eukaryotic translation initiation factor 4E (eIF4E) is required for cap-dependent initiation. In addition, eIF4Eoccurs in cytoplasmic foci such as processing bodies (PB) and stress granules (SG). We examined the role ofkey functional amino acid residues of eIF4E in the recruitment of this protein to cytoplasmic foci. We demonstrate that tryptophan residues required for mRNA cap recognition are not required for the recruitment ofeIF4E to SG or PB. We show that a tryptophan residue required for protein?protein interactions is essentialfor the accumulation of eIF4E in granules. Moreover, we show, by the analysis of two Drosophila eIF4E isoforms,that the tryptophan residue is the common feature for eIF4E for the transfer of activemRNA from polysomesto other ribonucleoprotein particles in the cytoplasm. This residue resides in a putative interactiondomain different than the eIF4E-BP domain. We conclude that protein?protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.","palabras_clave":"eIF4E|RNA metabolism|P bodies|stress granules"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89597,"idioma_id":4,"titulo":"Measurement error of 3D cranial landmarks of an ontogenetic sample using Computed Tomography","resumen":"Background\/Aim  Computed   Tomography (CT) is a powerful tool in craniofacial research that focuses   on morphological variation. In this field, an ontogenetic approach has   been taken to study the developmental sources of variation and to   understand the basis of morphological evolution. This work aimed to   determine measurement error (ME) in cranial CT in diverse developmental   stages and to characterize how this error relates to different types of   landmarks.  Material and methods  We   used a sample of fifteen skulls ranging from 0 to 31 years. Two   observers placed landmarks in each image three times. Measurement error   was assessed before and after Generalized Procrustes Analysis.  Results  The   results indicated that ME is larger in neurocranial structures, which   are described mainly by type III landmarks and semilandmarks. In   addition, adult and infant specimens showed the same level of ME. These   results are specially relevant in the context of craniofacial growth   research.  Conclusion  CT   images have become a frequent evidence to study cranial variation.   Evaluation of ME gives insight into the potential source of error in   interpreting results. Neural structures present higher ME which is   mainly associated to landmark localization. However, this error is   irrespective of age. If landmarks are correctly selected, they can be   analyzed with the same level of reliability in adults and subadults.","palabras_clave":"Craniofacial growth|Morphometry|Intra-observer error"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89598,"idioma_id":4,"titulo":"HeMoLab - Hemodynamics Modelling Laboratory: an application for modelling the human cardiovascular system","resumen":"In this work we present HeMoLab (Hemodynamics Modeling Laboratory), a   computational environment for modeling the Human Cardiovascular System.   Its integrates novel computational tools, running from medical image   processing to numerical simulation and visualization. As a simulation   tool, it allows to accommodate complex physiological and\/or   pathophysiological (virtual) scenarios aimed to retrieve detailed   information from the numerical computations. Such application makes   possible to speed up research in the study and analysis of the   cardiovascular system and, to provide a virtual laboratory for medical   training and education, and specialized Human Resources development. In   order to demonstrate the modeling and simulation capabilities of HeMoLab   some cases of use are presented.","palabras_clave":"Computational hemodynamics;|Computer graphics application; |Virtual laboratory; Integrated circulation; |Heterogeneous models"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89599,"idioma_id":4,"titulo":"Kinetic modeling of quality changes of chilled ready to serve lasagna","resumen":"Pre-cooked pasta, in particular lasagna, plays an important role in the market of chilled ready to serve meals. In this work we analyzed the evolution of the most important physical and sensory quality attributes of lasagna sheets during its refrigerated storage, at 0, 4 and 10 ºC. The quality of ready meal deteriorates with storage time, and food looses its freshness condition. The same behavior was observed for all analyzed characteristics: as the storage temperature increases, reaction rate (measured by the kinetic constant and activation energy) also increases, confirming the influence of temperature in quality loss. Besides, overall acceptability was the more sensitive attribute to temperature changes, with Q10 equal to 4, indicating an indirect but strong dependence of consumers? opinion on storage temperature.Finally, shelf life models, based on sensory analysis and on microbial spoilage, were compared, showing that the adopted sensory score determines which criterion is more restrictive.Kinetic data provides a useful tool to control the storage, ensuring good safety and sensory quality.","palabras_clave":"Cooked pasta|Shelf life|Sensory analysis|Quality loss kinetics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89600,"idioma_id":4,"titulo":"On the applicability of the exterior complex scaling method for scattering problems including Coulombic potentials","resumen":"We study some formal aspects of the exterior complex scaling (ECS) approach when imple-mented for both short and long-range potentials. In particular, we focus on the inconsistencies related tothe requirement of an arti&#64257;cial cut-o&#64256; of the potential in order to avoid exponential divergencies due to thecomplex rotation. For the pure two-body Coulomb potential we demonstrate analytically and numericallythat the ECS inner solution is indeed the correct one, thus reinforcing the method; the extraction of thetransition amplitude, however, remains problematic. We also show that a consistent application of the ECSmethod requires a distorted wave formulation, and two variants are proposed. Finally, we will propose anapproach equivalent to the original ECS but that avoids all formal di&#64259;culties. It is based on performingthe complex rotation on the basis functions rather than on the driven equation itself, and makes use ofSturmian functions with appropriately chosen outgoing boundary conditions. Our proposal di&#64256;ers fromone of the original versions of the ECS method, through the use of physically based basis functions ratherthan pure numeric ones.","palabras_clave":"COLLISIONS|COULOMBIC|STURMIANS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89601,"idioma_id":4,"titulo":"Band-structure effects in photoelectron-emission spectra from metal surfaces","resumen":"Photoelectron emission from the valence band of a metal surface due to the grazing incidence of ultrashortlaser pulses is studied in the framework of a distorted-wave formulation. We propose a model, named theband-structure-based\u2013Volkov (BSB-V) approximation, which takes into account the contribution of the bandstructure of the solid. The BSB-V approach is applied to calculate differential electron-emission probabilities forAl(111) and Be(0001) surfaces. A noticeable in&#64258;uence of the electronic band structure was observed in the caseof beryllium, while for aluminum such effects were found to play a minor role.","palabras_clave":"PHOTOELECTRON|METALS|VOLKOV|SCHRODINGER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89602,"idioma_id":4,"titulo":"Effect of Oviductal Secretion Components on the Fertilizing Capacity of Amphibian Sperm.  Biological and Ultrastructural Studies.","resumen":"The present study was carried out to analyze the fertilization-supporting activity of Rhinella arenarum&nbsp; egg-jelly components. Spermatozoa were treated with diffusible factor (DF) constituted by the components released from the jelly coat into deionized water or with full jelly (FJ) containing all the components secreted by the oviductal pars convoluta (PC) during the transit of the oocytes through the duct, or with washed jelly (WJ) constituted only by structural components. Both jellies were solubilized by ultraviolet irradiation. These gametes were used for ultrastructural and biological studies in order to determine the acrosome state and the fertilizing capacity. Additional experiments were performed by using Ca2+, a diffusible cation present in Rhinella arenarum jelly envelopes. Results demonstrated a marked increase in the acrosome reaction (AR) of sperm treated with FJ or DF compared to the controls (Ringer?s solution), no significant differences being observed between both treatments, while WJ showed low AR percentages similar to the ones obtained with the controls. The addition of Ca2+ induced an increase in this parameter in a dose-dependent manner, although the values reached with FJ or DF were not attained. The results of the 'in vitro' fertilization show a strong inverse association to the acrosome reaction (AR) rate. Treatment with Ca2+ at the concentration present in the jelly (6.3 ± 0.9 mM) inhibited the fertilizing capacity as a function of incubation time, showing that at 2 min there was a decrease in the fertilization percentages compared to 10% Ringer?s. Data indicated that Ca2+ present in jelly is involved in the AR induction but suggests the possible participation of other diffusible and\/or structural components of the oviductal secretion in this process.  ","palabras_clave":"AMPHIBIAN|FERTILIZATION|EGG JELLY|ACROSOME REACTION|CALCIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89603,"idioma_id":4,"titulo":"Histopathological and biological studies of the effect of cadmium on Rhinella arenarum gonads","resumen":"This study was to determine the lethal dose 50 (LD50) of CdCl2 in adult Rhinella arenarum and analyzed the effect of two sublethal doses (0.5 and 5 mg\/kg) of the xenobiotic in gonads. The 48 h LD50 were 50.0 and 49.8 mg\/kg for males and females respectively. Alterations in the ovary were evidenced by nuclear pleomorphism and cytoplasmic vacuolization of the oocytes at the early stages of development with the highest dose and an increase in the population of atretic oocytes. In the interstitial tissue we noticed congestion, edema and fibroblast proliferation. The nuclear maturation of the oocytes was affected by the xenobiotic in a dose- and time-dependent manner. In males, treatment with 5 mg\/kg of cadmium (Cd) caused a decrease in the concentration, viability and straight progressive motility of sperm while there was an increase in immotile sperm. Testis histopathology revealed dilated seminiferous tubules, disappearance of cysts, tissue disorganization and leukocyte infiltration. Numerous germ cells showed hydropic tumefaction or signs of focal necrosis. The Cd content in animals intoxicated gonads with the highest sublethal dose was significantly higher than in the control. Results indicate that R. arenarum gonads are target for the xenobiotic, compromising the formation of gametes competent for fertilization, the effective CdCl2 dose being 5 mg\/kg.","palabras_clave":"RHINELLA ARENARUM|CADMIUM|GONADS|REPRODUCTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89604,"idioma_id":4,"titulo":"Morphometric studies and taxonomic delimitation in Menonvillea scapigera and related species (Cremolobeae: Brassicaceae)","resumen":"Abstract Previous systematic treatments of Menonvillearecognized a group of six morphologically related species,the ?M. scapigera group,? distinguished by having pinnatelylobed leaves and united filaments of median staminalpairs. The number of recognized species ranged fromsix to two, one with three subspecies. In order to clarify thetaxonomy of this group, multivariate and univariate analysesof qualitative and quantitative characters from herbariumspecimens were performed. Additionally, to test themorphological results, the phylogenetic relationships anddegree of exclusive ancestry were studied using ITSsequences and the genealogical sorting index. Our resultssupport the recognition of three species (M. famatinensis,M. hirsuta, M. scapigera) delimited by a unique combinationof qualitative characters. Quantitative characterssupport the division of the latter species into two subspecies:scapigera and longipes. The molecular data are congruentwith the morphology and support the inclusion ofM. hookeri within M. scapigera. A key to taxa of theM. scapigera group is presented.","palabras_clave":"Brassicaceae|Menonvillea \u0002 |Systematics|South America \u0002 |ITS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89605,"idioma_id":4,"titulo":"Telomere instability is present in the progeny of mammalian cells exposed to bleomycin","resumen":"We analyzed the chromosomal aberrations involving telomeres in the progeny of mammalian cells exposed to the radiomimetic compound bleomycin (BLM) in order to determine if this antineoplastic drug induces long-term telomere instability. To this end, rat cells (ADIPO-P2 cell line, derived from adipose cells from Sprague-Dawley rat) were treated with a single concentration of BLM (2.5 µg\/ml), and chromosomal aberrations were analyzed 18 h and 10 days after treatment by using PNA-FISH with a pantelomeric probe [(TTAGGG)n repeats]. Cytogenetic analysis revealed a higher frequency of aberrations at 18 h and 10 days after treatment in BLM-exposed cultures vs. untreated cultures, although the yield ofBLM-induced aberrations 10 days after treatment decreased about 25% compared with the one at 18 h after treatment. Moreover, the level of telomerase activity in BLM-treated cells compared with that ofuntreated control cells was significantly higher at 10 days after treatment, but did not differ at 18 h after treatment. These data indicate that in terms of unstable aberrations, the in vitro clastogenic effect of BLM on ADIPO-P2 cells persists for at least 10 days after exposure. In addition, our data demonstrate, for the first time, that BLM-induced telomere instability in mammalian cells (cytogenetically detectable as incomplete chromosome elements and telomere FISH signal loss and duplication) persists for several generations after exposure. Moreover, the appearance of telomere fusions in BLM-exposed cells 10days after treatment suggests that this compound can induce delayed telomere instability. The increase in telomerase activity in BLM-exposed cells 10 days after treatment is accompanied by the presence ofaberrations directly related to telomere dysfunction. This fact suggests that telomerase is not directly involved in BLM-induced telomere instability.","palabras_clave":"BLEOMYCIN|INCOMPLETE CHROMOSOMES|TELOMERE INSTABILITY|TELOMERE DYSFUNCTION|LONG-TERM CLASTOGENIC EFFECT|MAMMALIAN CELLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89606,"idioma_id":4,"titulo":"Improved performance of polypropylene\/talc composites","resumen":"Talc functionalization by superficial grafting of acetoxy groups enhances matrix-filler adhesion and particle dispersion\/distribution of injection molded Polypropylene\/talc specimens. These effects, and the consequent particle size reduction, lead to improved composite final mechanical properties. &nbsp;DOI: 10.1002\/spepro.004405&nbsp;DOI: 10.1002\/spepro.004405Trabajo escrito a solicitud de la Society of Plastics Engineers (SPE) para su publicación on-line por su potencial tecnológico y la posibilidad de aplicación directa en las industrias del sector.&nbsp;","palabras_clave":"talc|surface treatments|composites"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89607,"idioma_id":4,"titulo":"Influence of talc genesis and particle surface on the crystallization kinetics of polypropylene\/talc composites","resumen":"Talc is a laminar silicate, considered an excellent nucleating agent for polypropylene (PP) crystallization. However, properties of PP\/talc composites depend on the morphology, size and surface of mineral particles. In this sense, talc from several ore, having different morphology, imparts specific characteristics on these materials. Also, taking into account that PP-talc adhesion is not necessarily good due to the apolar character of PP, talc surface has been modified in order to increase this parameter. In this work, the effects of talc genesis, geomorphologic aspects and particle surface characteristics on crystallization of PP\/talc composites are analyzed. Isothermal crystallization of PP\/talc composites was studied by using Differential Scanning Calorimetry, based on Avrami´s model. The final crystalline morphology of talc filled PP was analyzed by means Optical Microscopy (OM). The results show that the blocky talc morphology favors even more the crystallization compared with the platy one, at the same particle size. Taking into account the surface treatment used in this work, the talc surface is made hydrophobic and the particle delamination is favoured. As a consequence, so modified talc is very effective in increasing the crystallization temperature of PP and nuclei number formed during the crystallization respect to the untreated talc. ","palabras_clave":"composites|crystallization kinetics|talc morphology|surface modified talc"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89608,"idioma_id":4,"titulo":"Robust and compact PCF-based tunable femtosecond soliton source","resumen":"We present a high-speed wavelength tunable photonic crystal ber-based source capable of generating tunable femtosecond solitons in the infrared region. Through measurements and numerical simulation, we show that both the pulsewidth and the spectral width of the output pulses remain nearly constant over the entire tuning range from 860 to 1160 nm. This remarkable behavior is observed even when pump pulses are heavily chirped (7400 fs2),  which allows to avoid bulky compensation optics, or the use of another ber, for dispersion compensation usually required by the tuning device.","palabras_clave":"Photonic|Crystal|Fiber"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89609,"idioma_id":4,"titulo":"New insights into the role of spermine in Arabidopsis thaliana under long-term salt stress","resumen":"Polyamines (putrescine, spermidine and spermine) are traditionally implicated in the response of plants to environmental cues. Free spermine accumulation has been suggested as a particular feature of long-term salt stress, and in the model plant Arabidopsis thaliana the spermine synthase gene (AtSPMS) has been reported as inducible by abscisic acid (ABA) and acute salt stress treatments. With the aim to unravel the physiological role of free spermine during salinity, we analyzed polyamine metabolism in A. thaliana salt-hypersensitive sos mutants (salt overlay sensitive; sos1-1, sos2-1 and sos3-1), and studied the salt stress tolerance of the mutants in spermine and thermospermine synthesis (acl5-1, spms-1 and acl5-1\/spms-1). Results presented here indicate that induction in polyamine metabolism is a SOS-independent response to salinity and is globally over-induced in a sensitive background. In addition, under long-term salinity, the mutants in the synthesis of spermine and thermospermine (acl5-1, spms-1 and double acl5-1\/spms-1) accumulated more Na+ and performed worst than WT in survival experiments. Therefore, support is given to a role for these higher polyamines in salt tolerance mechanisms. ","palabras_clave":"POLYAMINES|SALINITY|SOS MUTANTS|SPERMINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89610,"idioma_id":4,"titulo":"Evolution of pressure profiles during the discharge of a silo","resumen":"We report measurements of the pressure profile in the outlet plane of a discharging silo. We observe that, whatever the preparation of the granular system, a dynamic Janssen effect is at play: the apparent mass of the grains (i.e., the part of their mass sustained by the base) is significantly smaller than their actual mass because of the redirection of the weight to the lateral wall of the container. The pressure profiles reveal a significant decrease in pressure in the vicinity of the outlet as the system discharges, whereas the flow rate remains constant. The measurements are thus a direct experimental proof that the flow rates of granular material through an aperture are not controlled by the local stress conditions.","palabras_clave":"Granular flow|Silo discharge"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89611,"idioma_id":4,"titulo":"Methyl 3-(2-hydroxybenzylidene)-2-methyldithiocarbazate","resumen":"In the title compound, C10H12N2OS2, the thione and S-methyl groups are syn. An intramolecular bifurcated O?H  (S,N) hydrogen bond occurs.","palabras_clave":"dithiocarbazate|crystal structure|biological |activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89612,"idioma_id":4,"titulo":"Bis(4-methylphenylsulfonyl)amino 4-methylbenzenesulfonate: a new member of the (RSO2)ON(SO2R )2 family","resumen":"The title compound, C21H21NO7S3, consists of an SO2ON-(SO2)2 central fragment and three terminal 4-methylphenylgroups each attached at a sulfonyl S atom. The most obviouscharacteristic is the presence of two nearly face-to-facebenzene rings, with their centroids separated by a rathershort distance [3.7808 (18) A &#730; ], but with a rather slantedrelative orientation [dihedral angle = 20.63 (13)] so as topreclude a strong intramolecular \u2013 interaction. The thirdbenzene ring is nearly perpendicular to the other two[dihedral angles = 71.62 (14) and 70.4 (13)]. The packing ofthe structure is directed by two C\u2014H  O hydrogen bondsinvolving aromatic H atoms (methyl H atoms are strictly noninteracting),which define chains running in the [100]direction. These one-dimensional chains evolve parallel toeach other and exhibit no significant lateral interactions.","palabras_clave":"BENZENESULFONATE|STRUCTURE|CRYSTAL|MOLECULAR GEOMETRY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89613,"idioma_id":5,"titulo":"3-Methyl-5-methylsulfanyl-1,3,4-thiadiazole-2(3H)-thione","resumen":"The title compound, C4H6N2S3, has two very similar moleculesper asymmetric unit. The nine non-H atoms in each moleculeare coplanar, both having comparable r.m.s. deviations of0.002 A &#730; . The main interest in the rather simple structureresides in a survey of very weak (in some cases, borderline)non-bonding interactions of various kinds, viz. S  S, C\u2014H  , \u2013 [centroid\u2013centroid distance = 3.8958 (13) A &#730; ] andC\u2014S   [3.7271 (11) A &#730; ], which act as the major driving forcefor the arrangement of molecules in the structure. The role oflong, though highly directional, S  S contacts (d &gt; 3.60 A &#730; ),and their relevance to the stability of the structure is discussed.","palabras_clave":"methylsulfanyl|thiadiazole|crystal structure|non bonding interactions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89614,"idioma_id":4,"titulo":"Benzyl3-[(E)-(furan-2-yl)methylidene]-2-methyldithiocarbazate","resumen":"In the title compound, C14H14N2OS2, the furan ring exhibits rotational disorder over two orientations, with an occupancy ratio of 0.508 (7):0.492 (7). The furan and phenyl rings formdihedral angles of 8.2 (6) (major occupancy component), 14.8 (6) (minor occupancy component) and 73.65 (9), respectively, with the central residue (C4N2S2), indicating a twisted conformation for the molecule. The methyl group and the thione S atom are syn and the conformation about the imine bond is E. In the crystal, C?H   interactions involving the phenyl ring are observed.","palabras_clave":"dithiocarbazate|crystal structure|disorder |conformation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89615,"idioma_id":4,"titulo":"DEVDase activity is induced in potato leaves during Phytophthora infestans infection","resumen":"Programmed cell death (PCD) occurs in plants, animals and several branches of unicellular eukaryotes asa part of developmental and\/or defense processes. Caspase proteases are universal mediators of animalapoptosis, a type of PCD. In plants, there are not animal caspase homologs; therefore, the characterizationof caspase-like activities is of considerable importance to our understanding of PCD in plants. Here wereport for the first time the involvement of caspase-3-like activity in the resistance mechanism of potatoto Phytophthora infestans infection. We showed that disease development in infected potato leaves isdependent of caspase-3-like activity. Unlike plant DEVDases previously reported, this DEVDase activitywas sensitive to the serine protease inhibitor PMSF. As reported for other subtilisin- like proteases withcaspase activity, potato DEVDase activity was mainly localized in the apoplast. We demonstrated that intotal protein extract DEVDase activity accounts for a 60% of serine proteases; however, this percentageincreases to 100% in the apoplast. Additionally, this caspase-3-like activity is constitutively expressed inthe apoplast of potato leaves. Total DEVDase activity is induced only in potato cultivars with high fieldresistance to P. infestans. These results show that potato caspase-3-like protease could constitute a tool inthe potato defense mechanisms resulting in partial resistance, although further assays would benecessary in order to elucidate its role.","palabras_clave":"DEVDase|Plant caspases|Potato- P. infestans|Apoplastic proteins"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89616,"idioma_id":4,"titulo":"Thermodynamic analysis of the Quantum Critical behavior of Ce-lattice compounds:  J.G. Sereni, arXiv: cond - \tmat 1202.1724, 8 Feb 2012 & Philosophical Magazine, overview, 11 Sept. 2012, 1-25, iFirst..","resumen":"A systematic analysis of low temperature magnetic phase diagrams of Ce compounds isperformed in order to recognize the thermodynamic conditions to be fullled by those systemsto reach a Quantum Critical regime or, alternatively, to identify other kinds of low temperaturebehaviors. Based on specic heat (Cm) and entropy results, three di\u000Berent types of phasediagrams are recognized: i) with the entropy involved in the ordered phase (SMO) decreasingproportionally to the ordering temperature (TMO), ii) those showing a transference of degreesof freedom from the ordered phase to a non-magnetic component, with their Cm(TMO) jumps(Cm) vanishing at nite temperature, and iii) those ending at a Critical Point at nitetemperature because their Cm do not decrease suciently with TMO producing an entropyaccumulation at low temperature.Only those systems belonging to the rst case, i.e. with SMO ! 0 as TMO ! 0, can beregarded as candidates for Quantum Critical behavior. Their magnetic phase boundaries deviatefrom the classical negative curvature below T  2:5 K, denouncing monotonous misleadingextrapolations down to T = 0. Di\u000Berent characteristic concentrations are recognized and analyzedfor Ce-ligand alloyed systems. Particularly, a pre-critical region is identied where thenature of the magnetic transition undergoes signicant modications, with its @Cm=@T discontinuitystrongly a\u000Bected by magnetic eld and showing an increasing remnant entropy atT ! 0. Physical constraints arising from the third law at T ! 0 are discussed and recognizedfrom experimental results.","palabras_clave":"Magnetism|Phase Transitions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89617,"idioma_id":4,"titulo":"Simultaneous Lot Sizing and Scheduling of Multistage Batch Processes  Handling Multiple Orders per Product","resumen":"A pair of precedence-based continuous-time formulations addressing the combined lot-sizing and scheduling of order-driven multistage batch facilities is presented. The proposed mixed-integer linear programming (MILP) models can handle multiple orders per product with different delivery dates, variable processing times and sequence-dependent changeovers. As each order may be filled by one or more batches, enough batches for each order ensuring optimality are initially defined. The two monolithic formulations are intended for sequential batch processes where batch integrity is preserved throughout the entire production system. However, lots of final products can be split to satisfy two or more orders. One of the approaches is based on a detailed MILP formulation allocating individual batches to units and ordering them in every unit. In contrast, the second methodology is specially designed for large scheduling problems. It first gathers batches for the same order into clusters, and then assigns clusters to units and sequences groups of batches in every unit. The larger the number of groups the more rigorous is the cluster-based formulation. Alternative sequencing constraints based on reliable assumptions were also tested. Several examples involving up to 92 batches have been successfully solved using one or both formulations.","palabras_clave":"MULTIPRODUCT BATCH PLANT|SCHEDULING|MONOLITHIC APPROACH|MILP MATHEMATICAL MODEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89618,"idioma_id":4,"titulo":"Positive selection of co-opted mobile genetic elements in a mammalian gene: If you can't beat them, join them","resumen":"The proopiomelanocortin (Pomc) gene encodes a prepropeptide with essential functions in the response to stress and energy balance, which is expressed in the pituitary and hypothalamus of vertebrate animals. Neuronal expression of Pomc is controlled by two distal enhancers named nPE1 and nPE2. Using transgenic mice, we observed that both enhancers drive identical expression patterns in the mammalian hypothalamus, starting at embryonic day 10.5, when endogenous Pomc expression commences. This overlapping enhancer activity is maintained throughout hypothalamic development and into adulthood. We also found that nPE1 and nPE2 were exapted as neuronal enhancers into the POMC locus after the sequential insertion of two unrelated retroposons. Thus, nPE1 and nPE2 are functional analogs and represent an authentic first example of convergent molecular evolution of cell-specific transcriptional enhancers. In this Commentary we discuss the following questions that remain unanswered: (1) how does transcriptional control of POMC operate in hypothalamic neurons of non-mammalian vertebrates? (2) What evolutionary forces are maintaining two discrete neuronal POMC enhancers under purifying selection for the last ~100 million years in all placental mammals? (3) What is the contribution of MaLRs to genome evolution?","palabras_clave":"POMC|retroposons|expression|exaptation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89619,"idioma_id":4,"titulo":"Bacterial signaling systems as platforms for rational design of new generations of biosensors","resumen":"Bacterial signal-responsive regulatory circuits have been  employed as platform to design and construct whole-cell  bacterial biosensors for reporting toxicity. A new generation of  biosensors with improved performance and a wide application  range has emerged after the application of synthetic biology  concepts to biosensor design. Site-directed mutagenesis,  directed evolution and domain swapping were applied to  upgrade signal detection or to create novel sensor modules.  Rewiring of the genetic circuits allows improving the  determinations and reduces the heterogeneity of the response  between individual reporter cells. Moreover, the assembly of  natural or engineered modules to biosensor platforms provides  innovative outputs, expanding the range of application of these  devises, from monitoring toxics and bioremediation to killing  targeted cells.","palabras_clave":"Bacterial signaling|biosensors"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89620,"idioma_id":5,"titulo":"Estudio de 'las capas del Cabo Ladrillero Superior' en el cabo homónimo, Mioceno Inferior de la cuenca Austral, Tierra del Fuego","resumen":"En los acantilados del cabo Ladrillero, situado sobre la costa atlántica de la Isla Grande de Tierra del Fuego, afloran parte de los depósitos cuspidales que rellenan la cuenca de antepaís Austral o de Magallanes. Estos depósitos del Mioceno inferior son conocidos como ?capas del Cabo Ladrillero? y ?capas del Cabo San Pablo?, siendo las ?capas del Cabo Ladrillero superior?las analizadas en este trabajo. La zona de estudio, situada a una decena de kilómetros al norte del frente orogénico emergente (Punta Gruesa), permitió reconocer cuatro asociaciones de facies que registran depósitos gravitacionales resedimentados en un ambiente marino supra batial y una cuña deltaica progradante y somerizante hacia el noreste. Entre los rasgos más conspicuos observados en esta sucesión se destacan bancos deformados, intervalos macizos y abundantes diques clásticos, cuyo análisis estadístico indica un patrón transtensivo. Los microfósiles documentados en el área y utilizados previamente como herramienta para sostener un ambiente marino profundo provienen de niveles estratigráficos infrayacentes y corresponden a niveles de la Formación&nbsp; Desdémona y las capas del Cabo Ladrillero inferior, aflorantes hacia el sur de la zona de estudio. Las evidencias sedimentológicas no son concluyentes respecto de la batimetría, pero la ausencia de turbiditas clásicas, flujos hiperpícnicos, la abundancia de bancos deformados y resedimentados, restos vegetales y fragmentos de carbón son compatibles con un ambiente somero y deltaico con altas tasas de aporte y pendientes inestables antes que un ambiente marino profundo, y sugieren una historia compleja de la evolución del relleno sedimentario que no se explica meramente con los esquemas basados exclusivamente en el contenido de foraminíferos que domina en la literatura.","palabras_clave":"Cuenca de antepaís|análisis tectono-sedimentario|diques clásticos|Tierra del Fuego"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89621,"idioma_id":4,"titulo":"The Structural Domains of Pseudomonas aeruginosa Phosphorylcholine Phosphatase Cooperate in Substrate Hydrolysis: 3D structure and enzymatic mechanism","resumen":"Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen. It colonizes different tissues by the utilization of diverse mechanisms. One of these may involve the breakdown of the host cell membrane through the sequential action of hemolytic phospholipase C and phosphorylcholine phosphatase (PchP). The action of hemolytic phospholipase C on phosphatidylcholine produces phosphorylcholine, which is hydrolyzed to choline (Cho) and inorganic phosphate by PchP. The available biochemical data on this enzyme demonstrate the involvement of two Cho-binding sites in the catalytic cycle and in enzyme regulation. The crystal structure of P. aeruginosa PchP has been determined. It folds into three structural domains.The first domain harbors all the residues involved in catalysis and is well conserved among the haloacid dehalogenase superfamily of proteins. The second domain is characteristic of PchP and is involved in the recognition of the Cho moiety of the substrate. The third domain stabilizes the relative position of the other two. Fortuitously, the crystal structure of PchP capturesmolecules of Bistris (2?][bis(2?]hydroxyethyl)amino]?]2?](hydroxymethyl)propane?]1,3?]diol) at the active site and at an additional site. This represents two catalytically relevant complexes with just one or two inhibitory Bistris molecules and provides the basis of the PchP function and regulation. Sitedirected mutagenesis along with biochemical experiments corroborates the structural observations and demonstrates the interplay between different sites for Cho recognition and inhibition. The structural comparison of PchP with other phosphatases of the haloacid dehalogenase family provides a three?]dimensional picture of the conserved catalytic cycle and the structural basis for the recognition of the diverse substrate molecules.","palabras_clave":"CRYSTALOGRAPHY|STRUCTURAL ENZYMOLOGY|CHOLINE|SITE-DIRECTED MUTAGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89622,"idioma_id":4,"titulo":"FastMat: A C++ library for multi-index array computations","resumen":"In this paper we introduce and describe an efficient thread-safe matrix library for computing element\/cell residuals and Jacobians in Finite Elements and Finite Volumes-like codes. The library provides a wide range of multi-index tensor operations that are normally used in scientific numerical computations. The library implements an algorithm for choosing the optimal computation order when a product of several tensors is performed (i.e., the so-called `multi-product´ operation). Another key-point of the FastMat approach is that some computations (for instance the optimal order in the multi-product operation mentioned before) are computed in the first iteration of the loop body and stored in a cache object, so that in the second and subsequent executions these computations are retrieved from the cache, and then not recomputed. The library is open source and freely available within the multi-physics parallel FEM code PETSc-FEM (http:\/\/www.cimec.org.ar\/petscfem) and it can be exploited on distributed and shared memory architectures as well as in hybrid approaches. We studied the performance of the library in the context of typical FEM tensor contractions.","palabras_clave":"Tensor Library|C++|FEM|FVM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89623,"idioma_id":4,"titulo":"Linearizing bad sequences: upper bounds for the product and majoring well quasi-orders","resumen":"Well quasi-orders (wqo´s) are an important mathematical tool for  proving termination of many algorithms. Under some assumptions upper  bounds for the computational complexity of such algorithms can be  extracted by analyzing the length of controlled bad sequences.    We develop a new, self-contained study of the length of bad  sequences over the product ordering of $NN^n$, which leads to known  results but with a much simpler argument.    We also give a new tight upper bound for the length of the longest  controlled descending sequence of multisets of $NN^n$, and use it  to give an upper bound for the length of controlled bad sequences in  the majoring ordering of sets of tuples. We apply this upper bound  to obtain complexity upper bounds for decision procedures of  automata over data trees.    In both cases the idea is to {em linearize} bad sequences, i.e.  transform them into a descending one over a well-order for which  upper bounds can be more easily handled.  ","palabras_clave":"WELL QUASI-ORDER|BAD SEQUENCE|TERMINATION PROOF|WELL ORDER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89624,"idioma_id":5,"titulo":"Memorias mapuches y Escuelas: desde las fundaciones al presente; entre lo nacional y lo propio","resumen":"En el presente artículo nos propusimos reflexionar sobre las memorias mapuches en la Patagonia argentina en su relación con las escuelas de las comunidades.  En ese marco, analizamos el lugar que ocupa la escuela en las narrativas fundacionales de origen, las marcaciones nacionales y mapuche, y el sentido de pertenencia comunitario. Asimismo nos enfocamos en los recuerdos, los olvidos y los usos del pasado que se localizan en la escuela, para repensar las apropiaciones y reconstrucciones de espacios y memorias. Particularmente nos centramos en el caso de la comunidad Mariano Epulef, de la provincia de Chubut y de la Agrupación Ancatruz de la provincia de Neuquén.  Siguiendo tres ejes de análisis, recorremos las narrativas fundacionales entrelazadas con las instituciones escolares; la escuela en tanto lugar de encuentros en la vida cotidiana y revalorizaciones comunitarias; y conmemoraciones y eventos donde se reactualizan historias del pasado y sentidos de lo propio. Así concluimos que en la escuela conviven, dialogan y se tensionan la matriz nacional con las marcaciones y autoadscripciones mapuche, pudiendo reelaborar significados, fortalecer apropiaciones e identidades e impugnar narrativas y sentidos hegemónicos.","palabras_clave":"MEMORIAS|MAPUCHE|ESCUELAS|ABORIGINALIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89625,"idioma_id":4,"titulo":"Wind induced damage in two regions of Argentina","resumen":"Information on wind-induced damage to civil structures in Argentina is scarce. In this paper, general trends regarding both  meteorological conditions and patterns of damage when damage occurred in two regions of Argentina are presented. The regions under  study were the north-east of Argentina (NEA) and the north-Patagonia. This research is based on a collection of data comprising field  surveys conducted after the passage of destructive storms, NCEP\/NCAR Reanalysis, a Global Data Assimilation System model and  other secondary sources like emergency services, local press, local councils and the National Weather Service. It is shown that both  regions have similar problems of vulnerability, even though they have different meteorological environments. Topics that must be  addressed to reduce the vulnerability of civil structures have been identified.","palabras_clave":"WIND|DAMAGE|BUILDING|FIELD SURVEY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89626,"idioma_id":5,"titulo":"Entre la exclusión y las transformaciones identitarias, construcción de una densidad psicosocial","resumen":"Esta ponencia se enmarca en el proyecto ?Luchas por y en el territorio:  fronteras en movimiento y prácticas de ciudadanía? (Programación  Científica UBACyT 2011-2014), que se propone estudiar las luchas  por y en el territorio, en distintos hábitats humanos, fuente de  sufrimiento\/frustración y\/o satisfacción\/realización. El territorio  es concebido como expresión de la espacialización del poder y  resultado de relaciones de cooperación y\/o conflicto. Tiene como  objetivo explorar y describir las formas que adopta la resistencia,  en determinados espacios\/territorios, donde se despliegan las  experiencias de vida de personas, grupos y comunidades relegadas.  En ese marco, analizamos una cooperativa de ex-cartoneros (como  ellos mismos se denominan), quienes llevan adelante una disputa  en el territorio, proponiendo nuevas formas de habitar el espacio.  Considerando el proceso por el cual alguien deja de ser cartonero  para situarse como trabajador o cooperativista, en este artículo  se indagará sobre las transformaciones de la identidad social y  laboral, atravesando los conceptos de ciudadanía y territorio. Para  ello hemos realizado entrevistas a los trabajadores de la cooperativa  y observaciones participantes en la misma, y analizado fuentes  secundarias.","palabras_clave":"TRANSFORMACIÓN|INDENTIDAD|PRECARIEDAD|COOPERATIVA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89627,"idioma_id":4,"titulo":"Chemical and mechanical properties of anodized cp-titanium in NH4 H2PO4\/NH4F media for biomedical applications","resumen":"Potentiostatic anodizing of commercially pure titanium, using ammonium phosphate and ammonium fluoride solution as electrolyte is studied. The objective is to generate titanium oxides on the surface and phosphor compounds presenting good protective and mechanical properties, and proper adhesion to the metal substrate to remain during surgical orthopedic procedures (implants). Two different applied potentials were used to obtain different surface oxides morphologies (20 and 30 V). The characterization and quantification of the generated deposits is presented as a starting point for the future application of these composite types of materials. X-ray Photoelectron Spectroscopy (XPS) and Raman spectroscopy techniques showed the presence of phosphor compounds and anatase (TiO2) as the main constitutive phases. Anodized samples presented less passivity current density with respect to the bare substrate, showing that the film formed by anodizing acts as an effective barrier to the electrolyte entrance to reach themetallic surface. Besides, mechanical properties of bare substrate were improved with the formation of anodic films: hardness value was increased in the oxide zones and the Young´s elastic modulus was decreased in the phosphorcompounds zones in the sample anodized with 30 V, generating an interface with different elastic properties that could be able to enhance the prosthesis performance. Nano-scratch tests showed a very ductile behavior and good adhesion of anodic films, without any apparent signs of cracks or delamination. ","palabras_clave":"Anodizing|Titanium|Phosphor-compounds"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89628,"idioma_id":4,"titulo":"Enhancing low cost stainless steel implants: bioactive silica-based sol-gel coatings with wollastonite particles","resumen":"A hybrid organic-inorganic sol-gel coating with the addition of  wollastonite particles is used as a potential solution to improve performance of low cost AISI 316L stainless steel. This work is focused on characterising the coatings by studying their synthesis and deposition, electrochemical, and in vitro and in vivo response. The coated implants presented in vitro Ca\/P-rich apatitic precursors phases on their surface and acceptable electrochemical behaviour. The in vivo response regarding bone formation seems to be excellent either with the implant in contact with bone marrow, in contact with the endostium or in contact with the trabecular bone. The bioactive and regenerative responses of bone tissue to the TEOS-MTES-wollastonite system  over-compensate the coating deterioration reaction, making these coatings as a good way to improve osseo-integration of stainless steel for long term use implants.","palabras_clave":"stainless steel|bioactive coatings|bone formation|corrosion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89629,"idioma_id":4,"titulo":"NOVEL Ca AND P COMPOUNDS ELECTRO-DEPOSITED ON Ti FOR IMPROVING BIOACTIVITY","resumen":"Ti and its alloys present good biocompatibility making them suitable for biomedical applications due to their low toxicity and their ability to promote a positive osseous tissue response after surface modification. The development of a surface film by anodisation would decrease the corrosion rate, minimising metal ion release to the biological media, and facilitating its osseointegration. The incorporation of Ca and P compounds on the anodised film is proposed as a way of improving the bioactivity of the metal implant. The aim of this work is to study the electrochemical properties and film structure of Ti anodic oxides grown in phosphoric acid, followed by the electrodeposition of calcium and phosphorous compounds. The anodisation treatment was performed at a constant potential of 30 V with respect to a counter-eletrode during 1 h. During the electrodeposition a supersaturated CaCl2 and NaH2PO4 solution was used, and the treatment was carried out at a constant current density of 3mA\/cm2 for 45 min. The modified surfaces were characterised by Raman spectroscopy and SEM to identify the chemical species present and their crystallographic phases as well as the general morphology of the surface. Phosphate was detected on the anodised samples previous to electrodeposition, indicating its incorporation from the anodising solution. Hydrated calcium phosphate was also identified on the surface after electrodeposition. Finally, electrochemical experiments were conducted in order to study the corrosion resistance of the surface modified samples. The barrier effect is enhanced with the anodising process and it is not further altered by the presence of the electrodeposited compound. ","palabras_clave":"TITANIUM|SURFACE MODIFICATION|PERMANENT IMPLANT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89630,"idioma_id":4,"titulo":"IN VITRO AND IN VIVO BEHAVIOR OF ANODISED ZIRCONIUM","resumen":"With the aim to evaluate the performance of zirconium as a potential permanent implant material, and the influence of its surface condition on biocompatibility, SBF immersion tests and in vivo press fit implantation on Wistar rats were carried out on zirconium anodised at 30 V in 1 mol\/L H3PO4 solution and unanodised zirconium. After 30 days of immersion in SBF solution, the surface morphology does not present changes on unanodised samples. Meanwhile when observed by SEM zirconium anodised at 30 V, was fully covered with globular aggregates of acicular crystals. Ca and P were the major elements detected with EDS on the aggregates, and according to Raman spectroscopy results, the composition was consistent with hydroxyapatite. These results are an indicative of bioactivity according to the international standard ISO 23317:2007(E); although exists some controversy on such affirmation in the literature. In osseointegration tests, wire samples were implanted on tibia and femur of Wistar rats. The specimens were slaughtered after 60 days of implantation, and histology studies were performed. New formed bone tissue attached to the implant was detected in both surface conditions. However, while on anodised zirconium bone formation was continuous all around the wire surfaces, on unanodised samples, zones with no bone growth were detected. As the amount of bone ? implant contact area resulted higher on anodised zirconium; the fixation of this surface modified material presents better perspectives compared to the unanodised metal. ","palabras_clave":"ZIRCONIUM|PERMANENT IMPLANT|ANODIC OXIDE|SURFACE MODIFICATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89631,"idioma_id":5,"titulo":"TILLANDSIA MYOSURA GRISEB. EX BAKER (BROMELIACEAE), UNA NUEVA CITA PARA LA FLORA DE LA PROVINCIA DE BUENOS AIRES (ARGENTINA)","resumen":"Se cita por primera vez para la Provincia de Buenos Aires Tillandsia myosura, coleccionadaen las inmediaciones del arroyo Pereyra, Parque Provincial y Reserva de la Biosfera ParquePereyra Iraola (Partido de Berazategui, Buenos Aires, Argentina). Esta especie, conocida hastael presente sólo para el sur de Uruguay y las provincias de Catamarca, Córdoba, Jujuy, La Rioja,La Pampa, Mendoza, Salta, San Juan, San Luis, Santiago del Estero y Tucumán en Argentinaes citada por primera vez para la Provincia de Buenos Aires, ampliándose su límite sur dedistribución. En el presente trabajo se describe e ilustra la especie, y se presenta una clave paradiferenciarla de especies afines de distribución congruente.","palabras_clave":"Tillandsia|clavel del aire|Parque Pereyra Iraola"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89632,"idioma_id":4,"titulo":"Outflow activity in the UCHII region G045.47+0.05","resumen":"Aims.        This work aims at investigating the molecular gas in the surroundings of the ultra-compact HII region G045.47+0.05 looking for evidence of molecular outflows.        Methods.        We  carried  out  observations  towards  a  region  of  2×2 centered  at  RA=19 14 25.6 ,Dec        =+11 09 27.6 (J2000)        using the Atacama Submillimeter Telescope Experiment (ASTE; Chile) in the CO J =3?2, CO J=3?2, HCO+J=4?3, and CS J=7?6 lines with an angular resolution of 22        &nbsp;We complement these observations with public infrared data.        Results.        We characterize the physical parameters of the molecular clump where G045.47+0.0 is embedded.  The detection of the CS J=7?6 line emission in the region reveals that the ultra-compact HII region G045.47+0.0 has not completely disrupted the dense        gas  where  it was  born.  The  HCO+ abundance  observed  towards  G045.47+0.0  suggests  there  is  molecular  outflow  activity in the region. From the analysis of the 12COJ=3?2 transition we report bipolar molecular outflows with a total mass of about 300 M.        We derive a dynamical time (flow?s age) of about 105yr for the outflow gas, in agreement with the presence of an ultra-compact HII region. We identify the source 2MASS 19142564+1109283 as the massive protostar candidate to drive the molecular outflows. Based        on the analysis of its spectral energy distribution, we infer that it is an early B-type star of about 15M. The results of this work        support   the scenario where the formation of massive stars, at least up to early   B-type stars, is similar to that of low-mass stars.","palabras_clave":"Stars: formation|ISM: jets and outflows|ISM: molecules"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89633,"idioma_id":4,"titulo":"Pressure tide gauge records from the Atlantic shelf off Tierra del Fue- go, southernmost South America","resumen":"Based on pressure tide gauge observations at three sites off the  Atlantic coast of Tierra del Fuego main island, time series spanning  one to seven months of bottom pressure and sea-level variations are  derived and analysed to reveal the major driving mechanisms. Ocean  tides account for 99.5% of the total energy of the sea-level  variations. The amplitudes and phases of a comprehensive set of tidal  constituents resulting from a harmonic tidal analysis are presented.  Exceptionally large shallow-water tides are identified. The second  largest contribution is due to the local inverse barometer model  accounting for up to 65% of the variance of the tide residual sea-level  variations. Close to the shore a significant topographic modulation of  the sea-level variations is revealed. The in situ observations are compared with six recent global ocean tide models, official tide  tables, and sea-surface heights derived from satellite altimetry data.  The amplitudes and phases predicted by the ocean tide models for the  semidiurnal and diurnal constituents agree with those derived from our  tide gauge records on average within 2 cm and 51, respectively. In the  time domain the tidal signal represented by the models deviates  typically by a few decimetres from that extracted from our records.  Absolute altimeter biases were determined for the Jason-2, Jason-1  extended mission, and Envisat satellite altimeters. Relative sea-level  variations are represented by the altimetry data with an accuracy of  the order of 5 cm.","palabras_clave":"TIDES|TIERRA DEL FUEGO|ATLANTIC|SEA LEVEL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89634,"idioma_id":4,"titulo":"Biotransformation of 2,6-diaminopurine nucleosides by immobilized Geobacillus stearothermophilus","resumen":"An efficient and green bioprocess to obtain 2,6-diaminopurine nucleosides using thermophilic bacteria is herein reported. Geobacillus stearothermophilus CECT 43 showed a conversion rate of 90 and 83% at 2 h to obtain 2,6-diaminopurine-2&#8242;-deoxyriboside and 2,6-diaminopurine riboside, respectively. The selected biocatalyst was successfully stabilized in an agarose matrix and used to produce up to 23.4 g of 2,6-diaminopurine-2&#8242;-deoxyriboside in 240 h of process. These nucleoside analogues can be used as prodrug precursors or in antisense oligonucleotide synthesis.","palabras_clave":"THERMOPHILIC MICROORGANISMS|NUCLEOSIDE PHOSPHORILASE|WHOLE CELL IMMOBILIZATION|PRODRUG PRECURSORS|TRANSGLYCOSYLATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89635,"idioma_id":5,"titulo":"'Señor San Javiel´´Ruega por nojotro lo´j pogre' La fiesta patronal del 3 de diciembre en San Javier (Santa Fe, Argentina), un espacio de resignificación?","resumen":"San Javier es una ciudad ubicada a orillas del río homónimo, en el norte de la provincia de Santa Fe, Argentina. Fundada en el siglo XVIII, surgió como una reducción jesuita que nucleaba a comunidades mocovíes. Durante dicho período se instauró la celebración de la fiesta patronal en honor a San Francisco Javier que continúa festejándose cada 3 de diciembre en la ciudad de San Javier. A lo largo del tiempo, el festejo ha sufrido transformaciones impulsadas por los distintos actores sociales. Dentro las características que ha adquirido dicho festejo, la procesión acuática enarbolada por el santo en compañía de una advocación de la Virgen María, es una de sus mayores particularidades. La fiesta constituye un espacio de resignificación donde los distintos participantes ponen en evidencia las diferentes realidades que conforman la ciudad y sus alrededores. En la apropiación de la figura del santo, tallada durante el período franciscano por artesanos mocovíes, se manifiesta la interacción conflictiva entre criollos e indígenas. El objetivo de este trabajo es analizar la fiesta popular religiosa en términos de un ritual donde se legitiman y se disputan espacios dentro de la comunidad. Por otro lado, nos interesa entender como la figura de San Francisco Javier condensa una multiplicidad de significados que definen distintas prácticas religiosas para los grupos intervinientes. ","palabras_clave":"FIESTA PATRONAL,|RITUAL|MOCOVI|SAN JAVIER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89636,"idioma_id":4,"titulo":"Corticosteroid administration reduces the concentration of hyaluronan in bronchoalveolar lavage in a murine model of eosinophilic airway inflammation","resumen":"OBJECTIVE:   To analyze the effect of corticosteroid administration on the concentration of hyaluronan (HA) in bronchoalveolar lavage (BAL) in a murine model of eosinophilic airway inflammation and to study the mechanisms involved.  MATERIALS AND METHODS:   Untreated-mice or mice treated with 1 ìg\/g\/day betamethasone (Bm) or 0.25 ìg\/g\/day(-1) budesonide (Bd) were sensitized and challenged with Dermatophagoides pteronyssinus (Dp) or saline (control group). The concentration of HA in BAL was determined by ELISA. In vitro migration assays were performed using a Boyden chamber and the expression of HA synthases (HAS) was analyzed by RT-PCR.  RESULTS:   We found a significant increase (P   CONCLUSION:   We conclude that corticosteroids prevent the increase in HA in BAL from Dp-challenged mice. This effect is associated with reduced expression of HAS and reduced phosphorylation of Akt and ERK in the lungs of challenged mice.","palabras_clave":"HYALURONAN|ASTHMA|BRINCHOALVEOLAR-LAVAGE|CORTICOSTEROIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89637,"idioma_id":4,"titulo":"Modeling multilayer adsorption of interacting polyatomic species on heterogeneous surfaces","resumen":"In the present work, a generalized lattice-gas model to study multilayer   adsorption of interacting polyatomic species on heterogeneous surfaces   is introduced. Using an approximation in the spirit of the well-known   Brunauer?Emmet?Teller (BET) model, a new theoretical isotherm is   obtained in one- and two-dimensional lattices and compared with Monte   Carlo simulation. In addition, the BET approach is used to analyze these   isotherms and to estimate the monolayer volume. In all cases, the   application of the BET equation leads to an underestimate of the true   monolayer capacity. However, significant compensation effects were   observed for heterogeneous surfaces and attractive lateral interactions.","palabras_clave":"ADSORPTION|SIMULATION |SURFACE|MULTILAYER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89638,"idioma_id":4,"titulo":"Percolation of aligned rigid rods on two-dimensional square lattices","resumen":"The percolation behavior of aligned rigid rods of length k (kmers) on two-dimensional square lattices has been studied by numerical simulations and finite-size scaling analysis. The kmers, containing k identical units (each one occupying a lattice site), were irreversibly deposited along one of the directions of the lattice. The process was monitored by following the probability RL,k(p) that a lattice composed of L × L sites percolates at a concentration p of sites occupied by particles of size k. The results, obtained for k ranging from 1 to 14, show that (i) the percolation threshold exhibits a decreasing function when it is plotted as a function of the kmer size; (ii) forany value of k (k &gt; 1), the percolation threshold is higher for aligned rods than for rods isotropically deposited; (iii) the phase transition occurring in the system belongs to the standard random percolation universality class regardless of the value of k considered; and (iv) in the case of aligned kmers, the intersection points of the curves of RL,k(p) for different system sizes exhibit nonuniversal critical behavior, varying continuously with changes in the kmer size. This behavior is completely different to that observed for the isotropic case, where the crossing point of the curves of RL,k(p) do not modify their numerical value as k is increased.","palabras_clave":"PERCOLATION|RIGID RODS|MONTE CARLO SIMULATIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89639,"idioma_id":4,"titulo":"Isotropic-nematic phase diagram for interacting rigid rods on two-dimensional lattices","resumen":"The phase behavior of interacting rigid rods of length k (k-mers) on two-dimensional square and triangular lattices has been studied by theoretical calculations in the framework of the lattice-gas model. The process was analyzed by comparing the dependence on coverage of the free energy per site of an isotropic submonolayer of interacting k-mers fiso(&#952;) with that corresponding to a fully aligned (nematic) system fnem(&#952;). The existence of an intersection point between the curves fiso(&#952;) and fnem(&#952;), which is indicative of the occurrence of an isotropic-nematic phase transition in the adlayer, allowed us to obtain the complete (temperature, coverage, k-mer size) phase diagram of the system.","palabras_clave":"NEMATIC ORDER|RIGID RODS|PHASE TRANSITIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89640,"idioma_id":4,"titulo":"Comment on 'effect of polydispersity on the ordering transition of adsorbed self-assembled rigid rods'","resumen":"The critical behavior of self-assembled rigid rods on a square lattice was recently reinvestigated by Almarza et al. [ Phys. Rev. E 82 061117 (2010)]. Based on the Binder cumulants and the value of the critical exponent of the correlation length, the authors found that the isotropic-nematic phase transition occurring in the system is in the two-dimensional Ising universality class. This conclusion contrasts with that of a previous study [ López et al. Phys. Rev. E 80 040105 (2009)] which indicates that the transition at intermediate density belongs to the q=1 Potts universality class. Almarza et al. attributed the discrepancy to the use of the density as the control parameter by López et al. The present work shows that this suggestion is not sufficient, and that the discrepancy arises solely from the use of different statistical ensembles. Finally, the necessity of making corrections to the scaling functions in the canonical ensemble is discussed.","palabras_clave":"Self Assembly|Polydispersity|Transitions|Rigid Rods"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89641,"idioma_id":4,"titulo":"Statistical thermodynamics of long straight rigid rods on triangular lattices: nematic order and adsorption thermodynamic functions","resumen":"The statistical thermodynamics of straight rigid rods of length k on triangular lattices was developed on a generalization in the spirit of the lattice-gas model and the classical Guggenheim-DiMarzio approximation. In this scheme, the Helmholtz free energy and its derivatives were written in terms of the order parameter, &#948;, which characterizes the nematic phase occurring in the system at intermediate densities. Then, using the principle of minimum free energy with &#948; as a parameter, the main adsorption properties were calculated. Comparisons with Monte Carlo simulations and experimental data were performed in order to evaluate the outcome and limitations of the theoretical model.","palabras_clave":"RIGID RODS|LATTICE- GAS|MONTE CARLO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89642,"idioma_id":4,"titulo":"Configurational entropy of systems with non-additive lateral interactions","resumen":"The configurational entropy per site of a lattice gas model with non-additive interactions between adsorbed particles for square, triangular and honeycomb lattices is discussed in the present study. The model used here assumes that the energy which links a certain atom with any of its nearest-neighbors strongly depends on the state of occupancy in the first coordination sphere of that adatom. By means of Monte Carlo simulations in the canonical ensemble by following the algorithm of parallel tempering and the thermodynamic integration method the configurational entropy per site has been calculated. By analyzing the behavior of the configurational entropy per site, the different low-temperature-ordered phases are described. The dependency of the critical temperature of the system as a function of characteristic parameters of the model is established.","palabras_clave":"MONTE CARLO SIMULATIONS|CONFIGURATIONAL ENTROPY|LATTICE GAS- MODEL|NON- ADDITIVE INTERACTIONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89643,"idioma_id":5,"titulo":"Convergencias y divergencias en experiencias de gestión local en áreas rurales de Argentina","resumen":"Abstract The applications of policies in Latin America contributed to macroeconomic stability but failed to redistribute income or dampen regional asymmetries within each country. Neither could maintain a employment growth, in Argentina case was a decline in employment level. This research began in august 2010, performed by the area of Desarrollo Instituto Nacional de Tecnología Agropecuaria (INTA) Oliveros y la facultad de Ciencias Agrarias de Universidad Nacional de Rosario, Santa Fe, Argentina. Selected experiences were organized in descriptive matrix considered key aspects of management of local development in rural areas. The aim of this paper is to analyze convergence and divergence in forty territorial management experiences were carried out in rural areas in different parts of Argentina. Through the results were observed crossing points where there are similarities and differences of the experiences analyzed. ","palabras_clave":"DESARROLLO LOCAL|ESCENARIOS|GESTION|TERRITORIO|CONVERGENCIAS|DIVERGENCIAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89644,"idioma_id":5,"titulo":"Aplicación de Métodos Acústicos Lineales y no Lineales en Paralisis Cordales Unilaterales","resumen":"Se presenta una nueva metodología que combina el análisis acústico y perceptual tradicional con algoritmos de la dinámica no lineal. Específicamente, coeficientes de Lyapunov aplicados a la medición de voces con alta perturbación. Se evaluaron emisiones de la vocal \/a\/ aislada y sostenida en 15 hablantes del español de Buenos Aires normales y 7 con parálisis unilaterales, de diferente sexo y edad. Las emisiones se registraron digitalmente en una cámara acústica con un micrófono dinámico vocal de respuesta conocida y a una intensidad de habla conversacional. Para la medición de los coeficientes se empleó un algoritmo Wolf (1985) modificado por Giovanni (1999). Se utilizaron índices tradicionales de perturbación de jitter (Horii, 1975 y Milenkovic 1987) y se evaluó perceptualmente el grado de severidad de la disfonía con la escala GRBAS (Hirano,1981). Se presentan para su comparación los valores de los coeficientes de Lyapunov y Jitter en voces normales y con parálisis. Las mayores alteraciones muestran exponentes de Lyapunov promedio de 0,83 versus 0,46 en voces normales. Los resultados y los gráficos obtenidos verifican el comportamiento caótico de la voz y demuestran la utilidad clínica de la medición. Los exponentes distinguen el grupo control respecto del grupo con parálisis.","palabras_clave":"ANALISIS ACUSTICO|METODOS LINEALES|METODOS NO LINEALES|PARALISIS CORDAL UNILATERAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89645,"idioma_id":4,"titulo":"Tautomeric Equilibria Analysis of &#946;-ketoamides by Mass Spectrometry","resumen":"Mass spectrometric evidence of tautomerism is reported for &#946;-ketoamides. The most abundant tautomers are ketoamido and Z-enolamido (both forming internal hydrogen bonds). The influence of temperature on the enol\/keto abundance ratios is studied in order to estimate the enthalpy difference for tautomeric equilibria. Theoretical calculations have been done in order to support experimental determinations. There are consistent trends between theoretical and experimental data: Enolization is favored by electron-withdrawing substiuents, bulky groups in &#945; position and temperature increase. Copyright © 2012 John Wiley & Sons, Ltd.","palabras_clave":"CHEMICAL|ORGANIC|TAUTOMERIC EQUILIBRIA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89646,"idioma_id":4,"titulo":"Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51","resumen":"Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the hypothalamus-pituitary-adrenocortical axis. Genetic variations of the FK506-binding protein of 51-kDa, FKBP51, one of the immunophilins bound to those steroid receptor complexes, were associated with the effectiveness of treatments against depression and with a major risk-factor for the development of post-traumatic stress disorders. Interestingly, immunophilins show polymorphisms and some polymorphic isoforms of FKBP51 correlate with a greater impairment of steroid receptor functions. In this review, we discuss different aspects of the role of FKBP51 in such steroid receptor function and the impact of genetic variants of the immunophilin on the dysregulation of the stress response. ","palabras_clave":"DEPRESSION|IMMUNOPHILIN|GLUCOCORTICOID RECEPTOR|HSP90|HYPOTHALAMIC-PITUITARY-ADRENAL AXIS|TETRATRICOPEPTIDE REPEAT DOMAIN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89647,"idioma_id":4,"titulo":"New records of the rare Histiotus magellanicus (Philippi, 1866) (Vespertilionidae) and other bats from Central Patagonia, Argentina","resumen":"ABSTRACT: Histiotus magellanicus (Philippi, 1866) is a poorly known Patagonian bat. Here we report on nine newly captured specimens and one unpublished locality from museum specimen that significantly improve our knowledge of this species? distribution, by incorporating two Argentine provinces and reducing the distributional gap between northern and southern historical records. The new records confirm H. magellanicus as a Subantarctic Forest endemic. In addition, we report new specimens and localities from four poorly known Patagonian bats for Chubut province: Histiotus macrotus, Myotis chiloensis, Lasiurus varius (Vespertilionidae) and Tadarida brasiliensis (Molossidae).RESUMEN: Nuevos registros del raro Histiotus magellanicus (Chiroptera, Vespertilionidae) y otros murciélagos de Patagonia Central, Argentina. Histiotus magellanicus (Philippi, 1866) es un murciélago patagónico muy pobremente conocido. Aquí reportamos nueve especímenes recientemente capturados y un espécimen de colección cuya localidad no había sido reportada hasta el momento. Las localidades aportadas mejoran considerablemente nuestro conocimiento de su distribución, incorporando a ella dos nuevas provincias argentinas y reduciendo considerablemente el vacío de datos entre los registros históricos del norte y sur de Patagonia. Los nuevos registros confirman a H. magellanicus como especie endémica de la ecorregión del Bosque Subantártico. Adicionalmente reportamos especímenes y localidades nuevos para la provincia de Chubut representando cuatro especies patagónicas pobremente conocidas: Histiotus macrotus, Myotis chiloensis, Lasiurus varius (Vespertilionidae) y Tadarida brasiliensis (Molossidae).","palabras_clave":"Central Patagonia.|Distribution|Molossidae|Vespertilionidae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89648,"idioma_id":4,"titulo":"Bat frugivory in two subtropical rain forests of Northern Argentina: testing hypotheses of fruit selection in the Neotropics","resumen":"Phyllostomid bats are prominent components of mammalian assemblages in the Neotropics. With many species  specialized in frugivory, phyllostomids represent major partners of &#64258;eshy-fruited plants in the mutualism  of seed dispersal. Here we present dietary data from two subtropical rainforests of Argentina, where  fruit diversity is low and thus offer unique opportunities to test hypotheses of diet selection originally  proposed for species-rich tropical assemblages. Particularly, we tested whether frugivorous phyllostomids   exhibit   pronounced   dietary   specialization   in   core   plant   taxa    where   greatly reduced  as compared to tropical rainforests. We analyzed dietary overlap and niche breadth of subtropical frugivorous   bats   on   the   basis   of   >1000   dietary   records   plus   >500   samples   from   a   fruit   offer   previous   the region.  We show that in the subtropics, frugivores from different genera remain faithful to their respective core   plant   taxa   with   few   exceptions,   rather   than   shifting   toward   alternative   fruit   resources   in the  study sites. This supports predictions of specialization, which is con&#64257;rmed to have a deep historical origin.   The   response   of   phyllostomid   ensembles   to   restricted   fruit   diversity   is   at   species composition:  absence of species for which preferred fruits do not occur in the sites. Taken together, these data   lend   strong   support   to   hypotheses   that   explain   coexistence   of   frugivorous   the   is   study   level   in   available   phyllostomids   the basis  of dietary specialization on core plant taxa with chiropterochorous fruits.","palabras_clave":"STURNIRA|ARTIBEUS|CAROLLIA|DIET SELECTION|FRUIT MORPHOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89649,"idioma_id":5,"titulo":"Nuevo cultivar de soja de la EEAOC: Yanasu RR.","resumen":"Durante las últimas décadas, el cultivo de la soja a nivel mundial tuvo un crecimiento tanto en superficie, como en productividad. En la Argentina sucedió de igual manera, particularmente a comienzos de este siglo, como resultante del uso de alta tecnología, convirtiendo a este cultivo y a sus subproductos en el pilar del sistema granario y exportador. El desarrollo del Noroeste Argentino (NOA) coincidió con el proceso a nivel nacional. La Estación Experimental Agroindustrial Obispo Colombres (EEAOC) de Tucumán buscó permanentemente producir cultivares adaptados a esta zona, siendo este el principal objetivo del subprograma Mejoramiento Genético del Proyecto Soja. Yanasu es una nueva variedad de soja liberada por la EEAOC, que completa su madurez fisiológica a los 123 días de su siembra (pertenece al grupo de madurez VIII corto) y que logra excelentes potenciales de rendimiento. Fue obtenida a través de cruzamiento y posterior avance generacional en la subestación de Monte Redondo (San Agustín, Tucumán). Yanasu RR fue sometida a ensayos comparativos de rendimiento (ECR) en cuatro diferentes sitios del área sojera tucumana durante la campañas 2005\/2006 y 2006\/2007, alcanzando rendimientos superiores a los testigos en la mayoría de los ensayos. Exhibe, entre otras características, baja o nula dehiscencia de vainas y un peso de 1000 semillas de 162,6 gramos. En cuanto a su sanidad, se destaca su tolerancia a las enfermedades cancro del tallo y mancha ojo de rana, así como ante patógenos de semillas como Cercospora kikuchii, Alternaria spp. y Macrophomina spp. Desde 2009\/2010 se la incluyó en la Red de Evaluación de Variedades Comerciales del NOA, destacándose por encima del testigo en 12 localidades de la región, con un excelente potencial de rendimiento.","palabras_clave":"GLYCINE MAX|RESISTENCIA A GLIFOSATO|NOROESTE ARGENTINO|MEJORAMIENTO GENÉTICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89650,"idioma_id":5,"titulo":"Estado sanitario de lotes comerciales de caña de azúcar destinados a la obtención de caña semilla durante el periodo 2008?2011 en Tucumán, R. Argentina","resumen":"El raquitismo de la caña soca, también conocido como ?achaparramiento de la caña soca? o RSD (por sus siglas en inglés, ratoon stunting disease), es causado por Leifsonia xyli subsp. xyli. La importancia de esta enfermedad se debe principalmente a la combinación entre la forma de reproducción del cultivo (asexual por estacas) y las características ecológicas del patógeno (sobrevive en los tejidos del hospedante), lo cual potencia la epidemiología del RSD. Esta enfermedad está ampliamente distribuida en todo el mundo y carece de síntomas externos e internos que puedan ser útiles para su diagnóstico. Debido al marcado efecto depresivo que tiene el RSD sobre el rendimiento de la caña de azúcar, el objetivo de este trabajo fue conocer el estado sanitario de lotes comerciales destinados a semilleros en Tucumán entre los años 2008 y 2011. Para el proceso de diagnóstico, en cada periodo se cumplieron los siguientes pasos que son los recomendados por la EEAOC: a) Planificación previa al diagnóstico. b) Toma de muestra. c) Procesamiento en invernáculo. d) Procesamiento en laboratorio (de acuerdo a protocolos de la Sección Fitopatología para el diagnóstico serológico de RSD). Se procesaron 522, 423, 315 y 830 muestras de 20 tallos cada una durante 2008, 2009, 2010 y 2011, respectivamente. En 2008 resultaron positivas 142 (27,2%), 124 en 2009 (29,3%), 104 en 2010 (33%) y 326 en 2011 (39.3%). Se observó un incremento del 44% en el porcentaje de muestras positivas desde 2008 a 2011. Al considerar los rangos de incidencia, los años 2008, 2010 y 2011 tuvieron similar comportamiento en la distribución del porcentaje de muestras positivas. Los mayores valores correspondieron al rango 1 a 10%, seguido del rango > a 20,1% y por último el de 10,1 a 20%. Esta tendencia no se observó en el 2009 donde los mayores porcentajes de muestras positivas fueron similares en los rangos 1 a 10% y mayor a 20,1%; y coincidiendo con el resto de los años analizados en el rango intermedio.  El 54,9% de las muestras positivas de 2008 tuvieron incidencias menores al 10% de tallos afectados. Por su parte en 2009 el 40,3% de la semilla que resultó positiva tuvo niveles de incidencia superiores al 20,1%, debido probablemente a la poca disponibilidad de semilla de calidad como consecuencia de las severas heladas registradas en la provincia. En 2010 y 2011, el 48 y 46,3% de las muestras positivas, respectivamente, tuvieron incidencias menores al 10%.","palabras_clave":"SACCHARUM OFFICINARUM|RAQUITISMO DE LA CAÑA SOCA|LEIFSONIA XYLI SUBSP. XYLI|DIAGNÓSTICO SEROLÓGICO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89651,"idioma_id":5,"titulo":"Análisis de las principales enfermedades del cultivo de soja durante la campaña 2011\/2012 en Tucumán y zonas de influencia, con énfasis en el tizón de la hoja (Cercospora kikuchii) y su manejo","resumen":"La campaña 2011\/2012 resultó muy desfavorable para la producción de soja [Glycine max (L.) Merr.] en el Noroeste Argentino (NOA), fundamentalmente debido a condiciones climáticas poco propicias durante el ciclo de cultivo. Prevalecieron durante la mayor parte de la campaña períodos de altas temperaturas y sequía que afectaron el crecimiento y desarrollo de las plantas. A esto se agregó la tardía ocurrencia de lluvias durante y después de la maduración de los cultivos. Las enfermedades del cultivo también se vieron influenciadas por las mencionadas condiciones ambientales. Con relación a campañas anteriores, hubo disminución en la ocurrencia de algunas patologías, pero incremento de otras que se vieron beneficiadas por las condiciones de estrés ambiental que prevalecieron. En el presente trabajo, se resumen los resultados de las prospecciones del estado sanitario de los cultivos de soja en la región y de la evaluación del comportamiento de cultivares frente al tizón de la hoja, causado por Cercospora kikuchii, realizadas por el personal de la Sección Fitopatología de la Estación Experimental Agroindustrial Obispo Colombres (EEAOC) durante la campaña 2011\/2012. Asimismo, se informa sobre los resultados de un ensayo donde se evaluaron ingredientes activos y momentos de aplicación para el control de la mencionada enfermedad. En la campaña 2011\/2012, los valores de severidad alcanzados por las patologías foliares fueron leves, como consecuencia de las condiciones ambientales poco favorables para su desarrollo durante casi todo el ciclo del cultivo. Las consecuencias de los importantes períodos de déficit hídrico ocurridos se tradujeron además en importantes mermas del rendimiento. Las lluvias del final de ciclo provocaron importantes niveles de mancha púrpura en la semilla, superiores a los de los últimos años. En cambio, la campaña resultó favorable para infecciones de la podredumbre carbonosa, cuya alta incidencia se pudo advertir en la mayoría de las localidades evaluadas. El tizón de la hoja se presentó en la campaña 2011\/2012 con valores que oscilaron entre 2% y 8% de superficie foliar afectada. En las últimas campañas, se habían registrado incrementos graduales en los valores de superficie foliar afectada por este patógeno, hasta alcanzar valores de 45% en la campaña 2010\/2011. Esto seguramente se tradujo en la presencia de niveles considerables de inóculo del patógeno en los restos de cultivo, lo que sumado a las precipitaciones ocurridas a fines de marzo y durante abril de 2012, condiciones óptimas para la infección de semilla en la etapa de maduración, permitieron que se alcanzaran altos valores de incidencia de la mancha púrpura de la semilla. Los niveles en lotes comerciales llegaron hasta 25%, mientras que en los ensayos de macroparcelas, los cultivares de grupos cortos evaluados (IV, V y VI) mostraron incidencias promedio del 5% al 10% y los de grupos largos (VII y VIII) del 10% al 20%.  El ensayo de control químico indicó diferencias en la eficiencia de los ingredientes activos ensayados para el control del tizón de la hoja.","palabras_clave":"GLYCINE MAX|PROSPECCIÓN DE ENFERMEDADES|CONTROL QUÍMICO|MANCHA PÚRPURA DE LA SEMILLA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89652,"idioma_id":5,"titulo":"Potencialidad de estudios arqueobotánicos sobre tártaro dental de cazadores recolectores de la provincia de La Pampa, Argentina","resumen":"      El  análisis del tártaro dental desde una perspectiva arqueobotánica, constituye un  acercamiento innovador en el estudio de la alimentación humana, la manipulación  de fibras vegetales con los dientes y el uso de plantas con fines medicinales.  Esto se debe a que la identificación de microfósiles de interés arqueológico  que quedaron entrampados en el sarro nos permite conocer qué plantas fueron  consumidas o manipuladas con los dientes. En este trabajo se analizan los  microfósiles extraídos del tártaro dental de individuos del sitio Chenque I y  se evalúa la técnica apropiada para recuperar y observar la mayor cantidad y  tipo de micropartículas. Las principales morfologías de fitolitos registradas  corresponden al tejido epidérmico de especies de Poaceae. Es notable la  presencia de restos de tejidos epidérmicos de frutos de Prosopis (sp.) y  gramíneas presentes en los molares. El tejido entrampado en el sarro, resulta  un dato de interés al momento de analizar las prácticas alimenticias y de salud  bucal de los cazadores recolectores pampeanos. Rev Arg Antrop Biol 14(Número Especial):105-113,  2012.  ","palabras_clave":"FITOLITOS|GRANOS DE ALMIDÓN|CHENQUE I|ALIMENTACIÓN HUMANA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89653,"idioma_id":5,"titulo":"TUC 300: nueva variedad de poroto negro de ciclo corto para el Noroeste Argentino","resumen":"El cultivo del poroto (Phaseolus vulgaris L.) ha sido y todavía es una alternativa productiva de importancia en la región subhúmeda seca y semiárida del Noroeste Argentino (NOA).  Además, por su fecha óptima de siembra, permite escalonar el uso de las maquinarias dentro de la empresa agropecuaria, cerrando con este la siembra de los cultivos estivales. El hecho de contar con variedades de poroto de ciclo corto constituye una alternativa más que destacada y brinda a los productores una posibilidad dentro de sus esquemas productivos, en especial para zonas donde existe riesgo de sequía (por escape parcial al estrés). Además, en fechas de siembras tardías permitiría escapar a las heladas tempranas. A esto se agrega que la disponibilidad de una variedad de ciclo corto posibilitaría un mejor uso de maquinaria y mano de obra a cosecha. Es decir, la siembra de variedades de ciclo corto en fechas óptimas para el cultivo, dentro de áreas productoras seguras, es otra posibilidad debido que al escalonarse la maduración de los lotes se dispondría tempranamente de maquinaria para cosecha y trilla, como así también de mano de obra. El objetivo del presente trabajo es presentar una nueva variedad de poroto negro, TUC 300, liberado por la Estación Experimental Agroindustrial Obispo Colombres (EEAOC), caracterizado por ser de ciclo corto (75 días), buena capacidad productiva y excelente calidad comercial de grano.  En la localidad de Los Altos, el genotipo TUC 300 presentó un comportamiento intermedio, con un rendimiento de 1873 kg\/ha. En San Agustín presentó la menor capacidad productiva (1017 kg\/ha), en tanto que en Pozo Hondo tuvo su mejor comportamiento, ubicándose tercero en el ranking con un rendimiento promedio para las tres campañas de 1550 kg\/ha. El genotipo TUC 300 presentó en las tres localidades reacción intermedia, en especial para virus y bacteriosis común.  Con respecto a su capacidad de adaptación a las condiciones ambiéntales y años de evaluación, se observa que TUC 300 también se destacó, siendo en la localidad de Los Altos donde mostró su mejor capacidad de adaptación.  El genotipo TUC 300 se caracteriza por tener 36 días a floración, mientras que variedades de ciclo más largo, como NAG 12, presentan 47 días; siendo TUC 510 un cultivar con 43 días a floración. Otra característica por la cual se distingue el nuevo cultivar es por su ciclo corto (75  días a cosecha), confirmando que su principal característica es la precocidad.  El genotipo TUC 300, se caracteriza por su follaje compacto, guías cortas, bajo desgrane, y una forma oblonga de grano; esta característica y arquitectura de planta y tipo de vaina favorecen su trilla directa. Sus días a floración (36) y su precocidad (75 días)  son el aspecto más sobresaliente a destacar (Tabla 4). Asimismo TUC 300 mantiene la reconocida buena calidad comercial de TUC 510. Su ciclo corto y su aceptable comportamiento productivo y de tolerancia las principales enfermedades virosicas, avaló su inscripción ante el Instituto Nacional de Semilla (INASE) como una nueva variedad de poroto negro obtenida por el Proyecto Legumbres Secas de la  EEAOC.","palabras_clave":"PHASEOLUS VULGARIS|MEJORAMIENTO GENÉTICO|SELECCIÓN DE CULTIVARES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89654,"idioma_id":5,"titulo":"El Intermedio Tardío en la Sierra del Cajón (Provincia de Catamarca). Avance de las investigaciones en Morro del Fraile","resumen":"Se presentan los resultados preliminares de las excavaciones practicadas en la localidad arqueológica de Morro del Fraile, en el interior de la Sierra del Cajón. La ubicación serrana y la cronología de transición entre los períodos medio e intermedio tardío aportan a la conformación de un panorama más representativo de la arqueología del área valliserrana, lo cual puede entenderse en términos de una deconstrucción de la secuencia agroalfarera de la subárea del NOA en cuestión. A partir del análisis de los hallazgos realizados en las excavaciones, la disposición estratigráfica de los mismos y su asociación con los fechados radiocarbónicos obtenidos, se discuten aspectos de las prácticas desarrolladas por los agentes del pasado, tales como: las actividades realizadas en sectores específicos del asentamiento y la posible función del mismo a lo largo del tiempo.","palabras_clave":"SIERRA DEL CAJÓN|PERÍODO INTERMEDIO TARDÍO|MORRO DEL FRAILE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89655,"idioma_id":7,"titulo":"Note storiche sul diritto penale argentino","resumen":"El trabajo analiza los aspectos esenciales que marcaron el derecho penal argentino desde la independencia hasta nuestros días. Además de mostrar las principales corrientes penales, analiza en qué medida el derecho argentino fue influenciado por ideas penales nacidas en España, Italia y Alemania.","palabras_clave":"HISTORIA|DERECHO|PENAL|ARGENTINO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89656,"idioma_id":4,"titulo":"Upregulation of the Angiotensin-Converting Enzyme 2\/Angiotensin-(1-7)\/Mas Receptor Axis in the Heart and the Kidney of Growth Hormone Receptor knock-out Mice","resumen":"Objective: Growth hormone (GH) resistance leads to enhanced insulin sensitivity, decreased systolic blood pressure and increased lifespan. The aim of this study was to determine if there is a shift in the balance of therenin-angiotensin system (RAS) towards the ACE2\/Ang-(1?7)\/Mas receptor axis in the heart and the kidney of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.pressure and increased lifespan. The aim of this study was to determine if there is a shift in the balance of therenin-angiotensin system (RAS) towards the ACE2\/Ang-(1?7)\/Mas receptor axis in the heart and the kidney of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.Growth hormone (GH) resistance leads to enhanced insulin sensitivity, decreased systolic blood pressure and increased lifespan. The aim of this study was to determine if there is a shift in the balance of therenin-angiotensin system (RAS) towards the ACE2\/Ang-(1?7)\/Mas receptor axis in the heart and the kidney of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.?7)\/Mas receptor axis in the heart and the kidney of a model of GH resistance and retarded aging, the GH receptor knockout (GHR&#8722;\/&#8722;) mouse.&#8722;\/&#8722;) mouse. Design: RAS components were evaluated in the heart and the kidney of GHR&#8722;\/&#8722; and control mice by immunohistochemistry and Western blotting (n=12 for both groups).immunohistochemistry and Western blotting (n=12 for both groups).RAS components were evaluated in the heart and the kidney of GHR&#8722;\/&#8722; and control mice by immunohistochemistry and Western blotting (n=12 for both groups).Results: The immunostaining of Ang-(1?7) was increased in both the heart and the kidney of GHR&#8722;\/&#8722; mice. These changes were concomitant with an increased immunostaining of the Mas receptor and ACE2 in bothtissues. The immunostaining of AT1 receptor was reduced in heart and kidney of GHR&#8722;\/&#8722;mice while that of AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.These changes were concomitant with an increased immunostaining of the Mas receptor and ACE2 in bothtissues. The immunostaining of AT1 receptor was reduced in heart and kidney of GHR&#8722;\/&#8722;mice while that of AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.The immunostaining of Ang-(1?7) was increased in both the heart and the kidney of GHR&#8722;\/&#8722; mice. These changes were concomitant with an increased immunostaining of the Mas receptor and ACE2 in bothtissues. The immunostaining of AT1 receptor was reduced in heart and kidney of GHR&#8722;\/&#8722;mice while that of AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.&#8722;\/&#8722;mice while that of AT2 receptor was increased in the heart and unaltered in the kidney. Ang II, ACE and angiotensinogen levelsremained unaltered in the heart and the kidney of GH resistant mice. These results were confirmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.firmed by Western blotting and correlated with a significant increase in the abundance of the endothelial nitric oxide synthase in both tissues.synthase in both tissues.ficant increase in the abundance of the endothelial nitric oxide synthase in both tissues.Conclusions: The shift within the RAS towards an exacerbation of the ACE2\/Ang-(1?7)\/Mas receptor axis observed in GHR&#8722;\/&#8722;mice could be related to a protective role in cardiac and renal function; and thus, possibly contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.observed in GHR&#8722;\/&#8722;mice could be related to a protective role in cardiac and renal function; and thus, possibly contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.The shift within the RAS towards an exacerbation of the ACE2\/Ang-(1?7)\/Mas receptor axis observed in GHR&#8722;\/&#8722;mice could be related to a protective role in cardiac and renal function; and thus, possibly contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.&#8722;\/&#8722;mice could be related to a protective role in cardiac and renal function; and thus, possibly contribute to the decreased incidence of cardiovascular diseases displayed by this animal model of longevity.","palabras_clave":"Angiotensin-(17)|AT1 receptor|Mas receptor|Growth hormone|Renin-angiotensin system"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89657,"idioma_id":4,"titulo":"Online Sample Conditioning for Portable Breath Analyzers","resumen":"Various innovative chemical sensors have been  developed in recent years to sense dangerous substances in air  and trace biomarkers in breath. However, in order to solve real  world problems, the sensors must be equipped with e&#64259;cient  sample conditioning that can, e.g., control the humidity, which  is discussed much less in the literature. To meet the demand, a  miniaturized mouthpiece was developed for personal breath  analyzers. A key function of the mouthpiece is to condition the  humidity in real breath samples without changing the analyte  concentrations and introducing substantial backpressure, which is achieved with optimized packing of desiccant particles.  Numerical simulations were carried out to determine the performance of the mouthpiece in terms of various controllable  parameters, such as the size, density, and geometry of the packing. Mouthpieces with di&#64256;erent con&#64257;gurations were built and  tested, and the experimental data validated the simulation &#64257;ndings. A mouthpiece with optimized performance reducing relative  humidity from 95% (27 000 ppmV) to 29% (8000 ppmV) whereas retaining 92% nitric oxide (50 ppbV to 46 ppbV) was built  and integrated into a hand-held exhaled nitric oxide sensor, and the performance of exhaled nitric oxide measurement was in  good agreement with the gold standard chemiluminescence technique. Acetone, carbon dioxide, oxygen, and ammonia samples  were also measured after passing through the desiccant mouthpiece using commercial sensors to examine wide applicability of  this breath conditioning approach.","palabras_clave":"CHEMICAL SENSOR|SAMPLE PREPARATION|MOUTHPIECE|BREATH ANALYZER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89658,"idioma_id":4,"titulo":"A new sensor for the assessment of personal exposure to volatile organic compounds","resumen":"To improve our understanding of indoor and outdoor personal exposures to common environmental  toxicants released into the environment, new technologies that can monitor and quantify the toxicants  anytime anywhere are needed. This paper presents a wearable sensor to provide such capabilities. The  sensor can communicate with a common smart phone and provides accurate measurement of volatile  organic compound concentration at a personal level in real-time, providing environmental toxicants data  every three minutes. The sensor has high speci&#64257;city and sensitivity to aromatic, alkyl, and chlorinated  hydrocarbons with a resolution as low as 4 parts-per-billion (ppb), with a detection range of 4 ppbe  1000 ppm (parts-per-million). The sensor\u2019s performance was validated using Gas Chromatography and  Selected Ion Flow Tube e Mass Spectrometry reference methods in a variety of environments and  activities with overall accuracy higher than 81% (r  2  > 0.9). Field tests examined personal exposure in  various scenarios including: indoor and outdoor environments, traf&#64257;c exposure in different cities which  vary from 0 to 50 ppmC (part-per-million carbon from hydrocarbons), and pollutants near the 2010  Deepwater Horizon\u2019s oil spill. These &#64257;eld tests not only validated the performance but also demonstrated  unprecedented high temporal and spatial toxicant information provided by the new technology.","palabras_clave":"CHEMICAL SENSOR|PERSONAL EXPOSURE|VOC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89659,"idioma_id":4,"titulo":"Effects of ethylene, cytokinin, and physical treatments on BoPaO gene expression of harvested broccoli","resumen":"Background: Broccoli is a highly perishable vegetable that shows an enhanced postharvest senescence and intense de-greening caused by chlorophyll degradation. One of the key steps of chlorophyll catabolism is the opening of chlorophyll tretrapyrrole catalyzed by Pheophorbide a oxygenase (PaO). In this work, we characterized the expression of a gene encoding a putative PaO under several chemical and physical treatments.Results: We cloned a fragment of a gene encoding a PaO from broccoli (BoPaO). The expression of BoPaO showed an important increment during postharvest senescence, in correlation with chlorophyll degradation. Furthermore, broccoli heads were treated with the hormones cytokinin and ethylene. Cytokinin delayed the increment of BoPaO expression whereas ethylene accelerated the process. Also, several postharvest treatments were applied in order to evaluate their effect on BoPaO expression. Samples treated with modified atmosphere, hot air, UV-C or white lights showed a delay in chlorophyll degradation and degreening. In most cases, the treatments also delayed the increment of BoPaO expression during senescence.Conclusion: A close correlation between chlorophyll degradation and expression of BoPaO was found during broccoli senescence. This relationship was corroborated in samples treated with different hormonal and physical applications.","palabras_clave":"BROCCOLI|SENESCENCE|CHLOROPHYLL DEGRADATION|PHEOPHORBIDE A OXIGENASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89660,"idioma_id":4,"titulo":"ZnO nanowire co-growth on SiO2 and C by carbothermal reduction and vapour advection","resumen":"Vertically aligned ZnO nanowires (NWs) were grown on Au-nanocluster-seeded  amorphous SiO2 films by the advective transport and deposition of Zn vapours obtained from the carbothermal reaction of graphite and ZnO powders. Both the NW volume and visible-to-UV photoluminescence ratio were found to be strong functions of, and hence could be tailored by, the (ZnO+C) source\u2013SiO2 substrate distance. We observe C flakes on the ZnO NWs\/SiO2 substrates which exhibit short NWs that developed on both sides. The SiO2 and C substrates\/NW interfaces were studied in detail to determine growth mechanisms. NWs on Au-seeded SiO2 were promoted by a rough ZnO seed layer whose formation was catalysed by the Au clusters. In contrast, NWs grew without any seed on C. A correlation comprising three orders of magnitude between the visible-to-UV photoluminescence intensity ratio and the NW volume is found, which results from a characteristic Zn partial pressure profile that fixes both O deficiency defect concentration and growth rate.","palabras_clave":"ZnO Nanowire|Vapour transport|Carbothermal reaction|Photoluminescence"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89661,"idioma_id":4,"titulo":"Vortex Metrology Using Fourier Analysis Techniques: Vortex Networks Correlation Fringes","resumen":"In this work, we introduce an alternativemethod of analysis in vortexmetrology based on the application ofthe Fourier optics techniques. The first part of the procedure is conducted as is usual in vortexmetrology foruniformin-plane displacement determination. On the basis of two recorded intensity speckled distributions,corresponding to two states of a diffuser coherently illuminated, we numerically generate an analytical signalfromeach recorded intensity pattern by using a version of the Riesz integral transform. Then, fromeachanalytical signal, a two-dimensional pseudophase map is generated in which the vortices are located andcharacterized in terms of their topological charges and their core\u2019s structural properties. The second part ofthe procedure allows obtaining Young\u2019s interference fringes when Fourier transforming the light passingthrough a diffracting mask with multiple apertures at the locations of the homologous vortices. In fact, weuse the Fourier transformas amathematical operation to compute the far-field diffraction intensity patterncorresponding to themultiaperture set. Each aperture fromthe set is associatedwith a rectangular hole thatcoincides both in shape and size with a pixel from recorded images.We show that the fringe analysis can beconducted as in speckle photography in an extended range of displacement measurements. Effects relatedwith speckled decorrelation are also considered. Our experimental results agree with those of speckle photographyin the range in which both techniques are applicable.","palabras_clave":"OPTICAL VORTEX METROLOGY|SPECKLE|FOURIER ANALYSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89662,"idioma_id":4,"titulo":"Speckle Decorrelation Influence on Measurements Quality in Vortex Metrology","resumen":"    We study speckle decorrelation effects in connection with conventional vortex metrology techniques. Our proposal is based on processing speckled images recorded by using two different experimental set- ups. In both schemes two laterally displaced patterns are generated: one scheme allows for obtaining undecorrelated speckle distributions and the other for decorrelated ones. Vortex networks associated with speckle patterns are analyzed by employing the usual tools developed for vortex metrology. For each recorded image, a 2D pseudo-phase map is generated on the basis of the Reisz transform. Then the vortices are located, and parameterized in terms of their topological charge, eccentricity, vorticity and angles between the zero crossing lines from the real and the imaginary parts of the analytical signal. After tracking the homologous vortices onto the maps, the histograms corresponding to the coordinate displacements are analyzed. We show that histograms interpretation is prone to failure due to its high sensitivity to decorrelation. Experimental evidences are presented to support the restrictions imposed by decorrelation of actual speckles due to uniform in-plane displacements ","palabras_clave":"DECORRELATION|OPTICAL VORTEX METROLOGY|SPECKLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89663,"idioma_id":4,"titulo":"Resistive switching in Ag-TiO2 contacts","resumen":"              Abstract              We study the electric pulse induced resistance switching of TiO2\u2013Ag   contacts at room temperature, exploring both unipolar and bipolar   switching modes. Initially we observed unipolar response. After hundred   pulsing cycles the unipolar switching response vanishes but the device   can still be operated in bipolar switching regime. The underlying   mechanism for resistance switching is modeled in terms of formation and   rupture of filament, and movement of oxygen vacancies.","palabras_clave":"dispositivos |nuevos materiales para la electrónica|memoria No volatil"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89664,"idioma_id":4,"titulo":"Magneto-Optical Enhancement by Plasmon Excitations in Nanoparticle\/Metal Structures","resumen":"Coupling magnetic materials to plasmonic structures provides a pathway to dramatically increase the magneto-optical response of the resulting composite architecture. Although such optical enhancement has been demonstrated in a variety of systems, some basic aspects are scarcely known. In particular, reflectance\/transmission modulations and electromagnetic field intensification, both triggered by plasmon excitations, can contribute to the magneto-optical enhancement. However, a quantitative evaluation of the impact of both factors on the magneto-optical response is lacking. To address this issue, we have measured magneto-optical Kerr spectra on corrugated gold\/dielectric interfaces with magnetic (nickel and iron oxide) nanoparticles. We find that the magneto-optical activity is enhanced by up to an order of magnitude for wavelengths that are correlated to the excitation of propagating or localized surface plasmons. Our work sheds light on the fundamental principles for the observed optical response and demonstrates that the outstanding magneto-optical performance is originated by the increase of the polarization conversion efficiency, whereas the contribution of reflectance modulations is negligible.","palabras_clave":"MAGNETOPHOTONIC CRYSTALS|PLASMONICS|PHOTONIC STRUCTURES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89666,"idioma_id":5,"titulo":"¿Hay límites para la creatividad interpretativa? A propósito del caso F., A. L. y la relativización de los derechos fundamentales","resumen":"Es un comentario a un caso jurisprudencial de la Corte Suprema Argentina.  El análisis se concentra en las siguientes cuestiones: (i)la confluencia, en el voto de la mayoría, de dos conceptos o, si se quiere, dos generaciones de derechos: los denominados \u201Cderecho de libertad\u201D o derechos de primera generación, y los derechos materiales a una prestación positiva por parte del Estado o derechos de segunda generación; (ii) la compatibilidad de la solución en F., A.L. con la línea jurisprudencial Portal de Belén \u2013 Tanus \u2013 Sánchez; (iii) las implicancias conceptuales de (i) y (ii) para la interpretación de la práctica constitucional argentina en general.   Con estos propósitos de estudio en miras, se delimitan los hechos (II. Hechos.) que dieron lugar al caso, así como sus aspectos procesal-constitucionales (III). Abordaje procesal constitucional.), entre los que se destaca el carácter abstracto que tenía el caso al momento de fallar la Corte Suprema. En la cuarta sección se aborda la cuestión de fondo discutida, y se describe la línea argumental del voto mayoritario (IV. Abordaje de la cuestión de Derecho. Línea argumental de fondo del voto mayoritario). Concluida esta aproximación descriptiva al fallo, se avanza sobre su valoración, a la luz de una propuesta de criterios de validez interpretativa, según la cual toda interpretación debe ser fiel a dos márgenes, uno semántico y otro moral o ideal (IV. Replanteo. La naturaleza controvertida de toda interpretación constitucional y convencional.). En ese contexto, se evalúa hasta qué punto la opción interpretativa de la Corte Suprema se ajusta a este doble baremo, lo cual conduce a la formulación de algunas consideraciones críticas acerca de las implicaciones de los principios que se sentaron en el caso (V. Algunas consideraciones críticas).","palabras_clave":"aborto|semántica|interpretación|staredecisis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89667,"idioma_id":4,"titulo":"Forest Landscape Restoration in the Drylands of Latin America","resumen":"Forest Landscape Restoration (FLR) involves the ecological restoration of degraded forest landscapes, with the aim of benefiting both biodiversity and human well-being. We first identify four fundamental principles of FLR, based on  previous definitions. We then critically evaluate the application of these principles in practice, based on the experience gained during an international, collaborative research project conducted in six dry forest landscapes of Latin America. Research highlighted the potential for FLR; tree species of high socioeconomic value were identified in all study areas, and strong  dependence of local communities on forest resources was widely encountered, particularly for fuelwood. We demonstrated that FLR can be achieved through both passive and active restoration approaches, and can be cost-effective if the increased provision of ecosystem services is taken into account. These results therefore highlight the potential for FLR, and the positive contribution  that it could make to sustainable development. However, we also encountered a number of challenges to FLR implementation, including the difficulty of achieving strong engagement in FLR activities among local stakeholders, lack of capacity for community-led initiatives, and the lack of an appropriate institutional and regulatory environment to support restoration activities.  Successful implementation of FLR will require new collaborative alliances among stakeholders, empowerment and capacity building of local communities to enable them to fully engage with restoration activities, and an enabling public policy context to enable local people to be active participants in the decision making process.","palabras_clave":"BIODIVERSITY|CONSERVATION|DRYLAND|ECOLOGICAL RESTORATION|FOREST LANDSCAPE|LATIN AMERICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89668,"idioma_id":4,"titulo":"Predominant regeneration strategy results in species-specific genetic patterns in sympatric Nothofagus s.s. congeners (Nothofagaceae)","resumen":"Life-history traits affect plant performance. Predominant regeneration modes, sprouting v. non-sprouting, will result in contrasting evolutionary and ecological responses that may be traced by nuclear markers. Sympatric Nothofagus Blume species provide the natural setting to test whether sprouters have a greater ability to maintain genetic diversity. In total, 28 populations along the entire distribution range of N. antarctica (G. Forst.) Oerst. were screened by eight polymorphic isozyme loci. We compared pairwise genetic patterns of the predominant sprouter N. antarctica with the mainly non-sprouter N. pumilio (Poepp. & Endl.) Krasser at 20 sympatric locations along their geographically concordant widespread range. Overall, the sprouter N. antarctica showed higher genetic variation throughout its range than did the non-sprouter N. pumilio. Mid-latitude populations of N. antarctica have maintained isozyme diversity, as inferred using genetic-landscape analysis. Despite the potential for inter-specific gene flow and past hybridisations, species identity was preserved by divergent selective forces acting on sympatric populations with distinct autoecological traits. Predominantly sprouting, as compared with mainly non-sprouting, has favoured long-term persistence of genet diversity in relatively large populations that were probably less affected by drift through time, thereby preserving molecular variants along its range. These variants, in combination with plasticity in diverse habitats, have resulted in greater resilience of N. antarctica under changing scenarios.","palabras_clave":"ISOZYME MARKERS|NON SPROUTER|PATAGONIA|SPROUTER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89669,"idioma_id":4,"titulo":"Interspecific and intergeneric hybridization in South American Rhamnaceae-Colletieae","resumen":"In Gondwanic Discaria, phenotypically intermediate  individuals exist between Discaria chacaye (G.  Don) Tortosa and Discaria articulata (Phil.) Miers, and  between D. chacaye and related Ochetophila trinervis  (Gillies ex Hook. & Arn.) Poepp. ex Miers. We studied  phenology, pollinators, parental crossability, morphological  features, and variation patterns on neutral markers.  Intermediates occur wherever parental taxa are sympatric  or in close proximity. Flowering was synchronous in  D. chacaye and D. articulata for 2 weeks. They also  shared three to six pollinator species (depending on site).  O. trinervis, which flowered later, occasionally overlapped  with D. articulata, with which it shared two pollinators.  Germinable seeds were obtained from hand pollinations  only from crosses with D. articulata as paternal parent and  D. chacaye as maternal parent. Sequencing of chloroplast  DNA revealed only two haplotypes. One occurred in  D. articulata, D. chacaye, and their intermediates, and the  other in O. trinervis and its intermediate with D. chacaye.  Only pure parentals had diagnostic alleles by isozymes,  whereas intermediates mainly showed those of D. chacaye.  Our results confirm intrageneric hybridization between  D. chacaye and D. articulata, and intergeneric hybridization  between D. chacaye and related O. trinervis.","palabras_clave":"Chloroplast DNA|Discaria|Hybridization|Isozyme electrophoresis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89670,"idioma_id":5,"titulo":"Variación genética en Nothofagus (subgénero Nothofagus)","resumen":"El subgénero Nothofagus consiste de cinco especies leñosas que están presentes en diversas asociaciones forestales de los bosques templados de Argentina y Chile. Dadas las variaciones del medio físico se esperan variaciones intraespecíficas estructurales yfuncionales con base genética. El análisis del acervo genético de múltiples poblaciones de las distintas especies a escala regional, mediante marcadores nucleares y citoplasmáticos con baja tasa de mutación, permitió resolver las relaciones filogenéticas y reconstruirsu historia biogeográfica en Patagonia, respectivamente. Secuencias nucleares ITS mostraron que N. pumilio divergió tempranamente y que N. antarctica resultó ser hermana del grupo monofilético conteniendo las tres especies siempreverdes (N. betuloides, N. dombeyi y N. nitida). Análisis filogeográficos mediante secuencias de ADN del cloroplasto reconstruyeron rasgos antiguos del paisaje del Oligoceno-Mioceno de Patagonia y develaron la existencia de paleohibridaciones. La señal contemporánea provista por polimorfismosisoenzimáticos contribuyó al análisis de patrones espaciales de variación como el efecto del rango geográfico, la formación de clines y ecotipos, las consecuencias genéticas de los disturbios naturales en relación con el modo predominante de regeneración (rebrotantey no-rebrotante) y la hibridación. Estudios en distintos ambientes habitados por N. antarctica y experimentales en jardín común y trasplantes recíprocos de N. pumilio en alturas contrastantes, mostraron que caracteres ecofisiológicos y morfológicos de los individuosson el resultado de selección natural y plasticidad. Las especies del subgénero Nothofagus son linajes antiguos que han desarrollado adaptaciones a lo largo de su historia evolutiva y, por lo tanto, tendrían el potencial de responder a cambios en el clima.","palabras_clave":"FILOGEOGRAFIA|NOTHOFAGUS|VARIACION GENETICA|VARIACION GEOGRAFICA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89671,"idioma_id":4,"titulo":"Genetic diversity and structure in Austrocedrus chilensis populations: Implications for dryland forest restoration","resumen":"In South America, 94% of dry-temperate lands present some degree of environmental degradation, highlighting the need for ecological restoration. We analyzed geographic patterns of genetic variation in Austrocedrus chilensis, a dominant conifer of the steppe-forest ecotone in the eastern Andes, to examine its potential for restoration. We sampled 67 locations in Argentina and estimated genetic parameters to determine the effects of historical factors affecting diversity, together with inbreeding and gene-flow, using 12 allozyme loci. Genetic diversity decreased southwards in eastern populations, which are marginal for the range of the species and patchily distributed, while high genetic admixture was detected in continuous western populations, possibly reflecting postglacial migrations from northern and eastern sources. Higher inbreeding (FIS> 0.14) was recorded in northern compared with southern populations, attributed to the impact of recent bottlenecks resulting from anthropogenic fires. Gene flow was found to be moderate overall (FST = 0.12). The implications of these results for restoration actions focusing on Austrocedrus were explored. Relatively small, inbred yet genetically diverse northern populations should be the subject of passive restoration efforts, while experimental common gardens should be established towards the south, to support active restoration approaches. This illustrates how ahead of time information on patterns of genetic variation can support restoration efforts for dryland tree species.","palabras_clave":"BEYOND-RANGE RESTORTATION|FIRE|GLACIATIONS|PASSIVE RESTORATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89672,"idioma_id":4,"titulo":"Shrinking Forests under Warming: Evidence of Podocarpus parlatorei (pino del cerro) from the Subtropical Andes","resumen":"Phylogeography in combination with ecological niche modeling (ENM) is a robust tool to analyze hypotheses on range shifts under changing climates particularly of taxa and areas with scant fossil records. We combined phylogeographic analysis and ENM techniques to study the effects of alternate cold and warm (i.e., glacial and interglacial) periods on the subtropical montane cold-tolerant conifer Podocarpus parlatorei from Yungas forests of the central Andes. Twenty-one populations, comprising 208 individuals, were analyzed by sequences of the trnL?trnF cpDNA region, and 78 sites were included in the ENM. Eight haplotypes were detected, most of which were widespread while 3 of them were exclusive of latitudinally marginal areas. Haplotype diversity was mostly even throughout the latitudinal range. Two distribution models based on 8 bioclimatic variables indicate a rather continuous distribution during cooling, while under warming remained within stable, yet increasingly fragmented, areas. Although no major range shifts are expected with warming, long-lasting persistence of cold-hardy taxa inhabiting subtropical mountains may include in situ and ex situ conservation actions particularly toward southern (colder) areas.","palabras_clave":"COLD-TOLERANT CONIFER|CP-DNA PHYLOGEOGRAPHY|MONTANE SPECIES|PODOCARPUS|SOUTH AMERICA|YUNGAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89673,"idioma_id":4,"titulo":"Evidence of heterogeneous selection on quantitative traits of Prosopis flexuosa (Leguminosae) from multivariate QST?FST test","resumen":"Prosopis flexuosa is an arboreal Leguminosae  that grows in arid and semiarid temperate zones of  Argentina, in the Monte eco-region. It is a promising native  forest species for recovering arid and semiarid regions be-  cause it plays an important role in erosion control as well as  in soil fertility. Furthermore, it provides diverse economical  resources. The main challenge to the forestry sector is find-  ing a balance between production and forest protection. For  this purpose, it is necessary to gather information about  genetic parameters. In this study, we measured the distribu-  tion of the variation of 14 quantitative traits in an experi-  mental half-sib stand, where families are representative of  hierarchically structured populations. We applied a multi-  variate extension of the classical QST?FST neutrality test to  determine the relative importance of drift versus selection in  the distribution of genetic variability. We found strong evi-  dence that different selective regimes act on different traits  and that selection favors different optima in each sampling  site. The selection to different optima is much stronger  among than within provenances. This result helps explain  the possible causes for the regional variation observed in P.  flexuosa and to define the management units and the evolu-  tionarily significant units for this species.","palabras_clave":"MULTIVARIATE QST| QUANTITATIVE TRAITS |MOLECULAR MARKERS | FST  |PROSOPIS FLEXUOSA  | FOREST TREES |SELECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89674,"idioma_id":4,"titulo":"Intraspecific variation in growth and morphology of landlocked Galaxias maculatus during the limnetic period of its life history","resumen":"Food availability and predation risk have  been shown to affect phenotypes during early life  history of fishes. Galaxias maculatus, a small fish  widely distributed around the southern hemisphere,  clearly exhibits a complex trade-off between feeding  and predation avoidance during growth over the  larval period. We studied the effect of different  environmental variables on diet, growth, mortality,  and morphology through field surveys and data  revision in the literature for limnetic G. maculatus  larvae in five oligotrophic lakes of Patagonia. Both  number of food categories and prey ingested by  larvae were directly related to zooplankton density.   Larval growth rate was related with zooplankton   density and temperature. Lakes with high zooplank-   ton densities and low predation risk had larvae with   deeper bodies and shorter caudal peduncles, while   in lakes with less food and high predation risk   larvae were slender with shallower bodies and   longer peduncles. Food availability and predation   risk seem to operate on the swimming performance of   G. maculatus larvae through the slenderness of the   body and the length of the caudal peduncle. The   observed phenotypic variation in growth and mor-   phology could be a key feature that has allowed this   species to successfully colonize a wide variety of   environments in the Southern hemisphere.","palabras_clave":"von Bertalanffy model|Oligotrophic lakes|Fish larvae|Zooplankton density|Phenotypic variation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89675,"idioma_id":4,"titulo":"Genetic and phenotypic differentiation among Galaxias maculatus populations in a Patagonian postglacial lake system","resumen":"Understanding the influence of landscape features on population differentiation is fundamental to evolutionary biology studies. We examined spatial patterns of genetic and phenotypic variability among Galaxias maculatus populations in a complex of four postglacial lakes in northwestern Patagonia differing in size and connectivity among them. A hierarchical Bayesian analysis grouped the individuals collected from 11 localities into 3 genetic clusters, first defining the 28 populations of the two large lakes and separating the two small lakes in subsequent analysis. Genetic structuring was restricted within large lakes. It is known that the larval stage of Galaxias maculatus migrate to the limnetic zone of Patagonian lakes, possibly exerting an homogenizing 31 effect on gene flow within lakes. Gene flow asymmetry and divergences among lakes can be  32 explained by a combination of landscape characteristics and the presence of predators in the short streams that connect them. Individuals from the small lakes are the most divergent morphologically and genetically. The population in the isolated Redonda Lake, exhibit meristic differences as well, suggesting strong drift and environmental effects. This population is likely to have been isolated following the decline in water level of a paleolake that existed in this region ca. 13.2 Ka BP.","palabras_clave":"Galaxias maculatus|genetic structuring|morphometrics,|meristic counts"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89676,"idioma_id":4,"titulo":"Retrieving the spatial distribution of cavity modes in dielectric resonators by near-field imaging and electrodynamics simulations","resumen":"For a good performance of photonic devices whose working principle is based on the enhancement of electromagnetic fields obtained by confining light into dielectric resonators with dimensions in the nanometer length scale, a detailed knowledge of the optical mode structure becomes essential. However, this information is usually lacking and can only be indirectly obtained by conventional spectroscopic techniques. Here we unraveled the influence of wire size, incident wavelength, degree of polarization and the presence of a substrate on the optical near fields generated by cavity modes of individual hexagonal ZnO nanowires by combining scanning near-field optical microscopy (SNOM) with electrodynamics calculations within the discrete dipole approximation (DDA). The near-field patterns obtained with very high spatial resolution, better than 50 nm, exhibit striking size and spatial-dispersion effects, which are well accounted for within DDA, using a wavevector-dependent dipolar interaction and considering the dielectric anisotropy of ZnO. Our results show that both SNOM and DDA simulations are powerful tools for the design of optoelectronic devices able to manipulate light at the nanoscale.                                       ","palabras_clave":"ZnO|Nanowires|SNOM|DDA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89677,"idioma_id":4,"titulo":"Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria","resumen":"Before weaning, dairy calves are susceptible to many pathogens which can affect their subsequent performance. The use of lactic acid bacteria (LAB) has been identified as a tool to maintain the intestinal microbial balance and to prevent the establishment of opportunistic pathogenic bacterial populations. However, a consensus has not been reached as to whether probiotics may be effective in reducing the prevalence of gastrointestinal diseases in young calves. The aim of this meta-analysis was to assess the effect of probiotics on diarrhea incidence and the intestinal microbial balance. LAB supplementation has been shown to exert a protective effect and to reduce the incidence of diarrhea (relative risk, RR = 0.437, 95% confidence interval (CI) 0.251-0.761). In the subanalysis, this protective effect of the probiotics against diarrhea was observed only in trials that used whole milk (RR = 0.154, 95% CI 0.079-0.301) and trials that used multistrain inocula (RR = 0.415, 95% CI 0.227?0.759). Probiotics did not improve the fecal characteristics (standardized mean difference, SMD =  0.4904, 95% CI  1.011?0.035) and were unable to change the LAB:coliforms ratio (SMD = 0.016, 95% CI  0.701?0.733). Probiotics showed a beneficial impact on the LAB:coliforms ratio in the subanalysis that included trials that used whole milk (SMD = 0.780, 95% CI 0.141?1.418) and monostrain inocula (SMD = 0.990, 95% CI 0.340?1.641). The probability of significant effects (probiotic positive effect) in a new study was >0.70 for diarrhea and fecal consistency. Whole milk feeding improved the action of the probiotic effect on the incidence of diarrhea and LAB:coliforms ratio. The probability to find significant effects in the diarrhea frequency and LAB:coliforms ratio was higher (P > 0.85) if the new studies were conducted using whole milk to feed calves. This paper defines the guidelines to standardize the experimental designs of future trials. LAB can be used as growth promoters in calves instead of antibiotics to counteract the negative effects of their widespread use.","palabras_clave":"PROBIOTIC|LACTIC ACID BACTERIA|CALVES|META-ANALYSIS|DIARRHEA|ANIMAL HEALTH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89678,"idioma_id":5,"titulo":"APLICACIÓN DE METODOLOGÍAS CUALI-CUANTITATIVAS PARA EL ANÁLISIS DE FACTORES CONDICIONANTES EN PROCESOS DE ADECUACIÓN SOCIO-TECNICA DE ENERGIAS RENOVABLES","resumen":"El trabajo presenta un conjunto de herramientas metodológicas que fueron aplicadas en el estudio de procesos de adecuación socio-técnica de tecnologías de energía solar. La base conceptual se sustenta en la importancia y alcance de los métodos cualitativos y de evaluación multi-criterio. Para el análisis de la información se utilizaron técnicas de triangulación mediante las cuales se identificaron los factores y sub-factores condicionantes de los procesos estudiados. La herramienta de Comparación por pares y una adaptación de la Dinámica de destrezas&nbsp; (Sistemas de Análisis Social) fueron aplicadas para la identificación de los sub-factores críticos y análisis de interacción de los factores respectivamente. Los factores condicionantes identificados fueron: tecnología solar, participación de la comunidad, participación de los técnicos, articulación inter-institucional, logística y seguimiento del proyecto, estructura de la comunidad. El análisis especificó una fuerte relación de interdependencia entre los factores, comprobando la importancia de abordar de manera integral estos procesos complejos.","palabras_clave":"INVESTIGACION CUALITATIVA|ADECUACION SOCIO-TECNICA|ENERGIAS RENOVABLES|FACTORES CONDICIONANTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89679,"idioma_id":4,"titulo":"Vectorial signalling mechanism required for cell-cell communication during sporulation in Bacillus subtilis","resumen":"Spore formation in Bacillus subtilis takes place in a sporangium consisting of two chambers, the forespore and the mother cell, which are linked by pathways of cell-cell communication. One pathway, which couples the proteolytic activation of the mother cell transcription factor sigma E to the action of a forespore synthesized signal molecule, SpoIIR, has remained enigmatic. Signalling by SpoIIR requires the protein to be exported to the intermembrane space between forespore and mother cell, where it will interact with and activate the integral membrane protease SpoIIGA. Here we show that SpoIIR signal activity as well as the cleavage of its N-terminal extension is strictly dependent on the prespore fatty acid biosynthetic machinery. We also report that a conserved threonine residue (T27) in SpoIIR is required for processing, suggesting that signalling of SpoIIR is dependent on fatty acid synthesis probably because of acylation of T27. In addition, SpoIIR localization in the forespore septal membrane depends on the presence of SpoIIGA. The orchestration of sigma E activation in the intercellular space by an acylated signal protein provides a new paradigm to ensure local transmission of a weak signal across the bilayer to control cell-cell communication during development.","palabras_clave":"sporulation|Bacillus subtilis|sigma E activation|signalling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89680,"idioma_id":4,"titulo":"On the orientation of fibres in structural members fabricated with self compacting fibre reinforced concrete","resumen":"The incorporation of fibres into concrete produces important benefits, mainly on the residual load-bearing capacity. These improvements depend on the type, content and orientation of the fibres, being a strong relationship between the number of fibres in the fracture surfaces and the post peak parameters. Although the fibres could be homogeneously distributed after mixing, the casting and compaction processes can significantly affect the fibre distribution and orientation, and consequently the mechanical performance of the material. In the case of Fibre Reinforced Self Compacting Concrete (FR-SCC) the existence of significant flow and wall effects may influence fibre orientation. This paper analyzes the fibre orientation in thin structural elements cast with FR-SCC and its effects on the residual mechanical properties. A slab of 0.90 x 1.80 x 0.09 m, a wall of 0.50 x 2.00 x 0.08 m, and a beam of 0.15 x 0.15 x 2.50 m were selected as representative elements where different concrete flow conditions take place. A strong heterogeneity in the orientation of the fibres was found. The fibre orientation varied with the flow rate and with the wall effect; the thickness of the elements or the proximity to the bottom of the moulds appeared as important variables. It was demonstrated that in thin elements the residual mechanical properties can be quite different when diverse zones and\/or directions of the structural elements are considered.","palabras_clave":"FIBRES|ORIENTATION|RESIDUAL STRENGTH|SELF COMPACTING CONCRETE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89681,"idioma_id":5,"titulo":"Estudio de las Propiedades Mecánicas y de Transporte en hormigones con fibras en estado fisurado","resumen":"El estudio del hormigón con fibras en estado fisurado representa una necesidad actual considerando que tanto el tamaño de las fisuras como su estabilidad en el tiempo constituyen aspectos relevantes al momento de valorar la durabilidad de este material de alta performance. Este trabajo estudia el comportamiento residual de un hormigón reforzado con 60 kg\/m3 de fibras de acero conformadas en sus extremos. Se analizan las propiedades mecánicas bajo cargas de larga duración sobre vigas a las que se les realizaron fisuras con anchos comprendidos entre 0,2 y 3,5 mm, además de cargas sostenidas se incluyen eventos de carga y descarga. Por otro lado, para evaluar las propiedades de transporte se realizaron ensayos de permeabilidad al agua y absorción capilar; para ello se emplearon rodajas de 150 mm de arista y 60 mm de espesor a las que se les provocaron fisuras de diverso espesor mediante cargas de compresión diametral. Entre las conclusiones se indican las condiciones de estabilidad frente a cargas de larga duración para un hormigón reforzado con fibras que posee un comportamiento post fisuración con endurecimiento. También se muestra que el ancho de fisura afecta en forma diferencial a las propiedades de transporte, mientras el coeficiente de permeabilidad crece en forma significativa para anchos mayores a 0,1 mm, los parámetros de absorción capilar sólo muestran una tendencia clara para fisuras de pequeño espesor.","palabras_clave":"ABSORCIÓN CAPILAR|CARGAS DE LARGA DURACIÓN|FISURAS|HORMIGÓN REFORZADO CON FIBRAS|PERMEABILIDAD"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89682,"idioma_id":4,"titulo":"Rescue of a    Whole-Farm System: Crystal Clear in Action","resumen":"This paper presents a case study of an agricultural project. From a desktop research model (stage 1), a web-based whole-farm simulator was developed applying a waterfall life cycle (stage 2) but several problems were detected and the project failed. The project was continued (stage 3) applying crystal clear agile method, which suited better the requirements. An efficient team communication and the frequent delivery of usable code increasingly contributed to the sponsor´s satisfaction. It was positively concluded that crystal clear was able to rescue the project and that it could be applied in a short-term period without major difficulties.","palabras_clave":"CRYSTAL CLEAR| AGRICULTURE SYSTEM  |WEB-BASE SIMULATOR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89683,"idioma_id":4,"titulo":"By-catch composition of the Patagonian scallop fishery: the fishes.","resumen":"An inventory of 24 fish species incidentally caught by the Patagonian scallop fleet in the SW Atlantic Ocean is provided for the first time. The most frequent species were Psammobatis spp. (81.36%), Bathyraja brachyurops (75.14%), B. macloviana (73.45%), Patagonotothen ramsayi (66.10%), Merluccius hubbsi (53.67%) and B. albomaculata (50.28 %). Many of the recorded chondrichthyes are considered vulnerable or endangered species. The number of taxa (fishes + invertebrates) that conforms the by-catch of the fishery was increased and updated to nearly 200.","palabras_clave":"BATHYRAJA|BY-CATCH|SCALLOP FISHERY|DISCARDS|SW ATLANTIC OCEAN|PATAGONOTOTHEN RAMSAYI"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89684,"idioma_id":4,"titulo":"Specifying and Verifying Declarative Fluent Temporal Logic Properties of Workflows","resumen":"In this paper, we present a characterization of workflows as labeled transition systems, focusing on an encoding of workflow specifications based on workflow patterns. This encoding models tasks in a convenient way, enabling us to exploit fluent linear time temporal logic formulas for capturing typical constraints on workflows. Fluents enable us to flexibly characterize the activities associated with workflow tasks, and also to easily express a wide range of constraints on workflows. Moreover, our characterization of workflows as labeled transition systems, and the use of fluent linear time temporal logic as a language to express workflow properties, allows us to employ model checking for automatically guaranteeing that a property is satisfied by a workflow, or generating violating workflow executions when such property does not hold.  We use YAWL as a language for expressing workflows. Our characterization of workflows as labeled transition systems is implemented in a tool that translates YAWL models into FSP, and then employs the LTSA tool to automatically verify properties of workflows, expressed as fluent linear time temporal logic properties, on the resulting FSP models.","palabras_clave":"Workflows|Model Checking|Fluent Linear Time Temporal Logic"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89685,"idioma_id":4,"titulo":"Deformations of frozen droplets formed at -40°C","resumen":"The optical properties of cirrus clouds are frequently computed with respect to various size distributions and ice crystal shapes; in general it is considered that the small ice crystals are quasi-spherical. This approximation can lead to significant errors in the analysis of the in situ microphysical data and also in the theoretical study of the radiative properties of cirrus clouds. Effective size and aspect ratio of the particles are the key parameters required to determine the optical parameters that are included in modeling and prediction of climate; their parameterizations need to be as accurate as possible. In this work, laboratory experiments were conducted to study the ice crystal shape formed from the freezing of water droplets at -40ºC. Liquid and ice clouds were separately formed and sampled in a cloud chamber at -30 and -40ºC, respectively. The water droplet effective diameter ranged from 8 to 20 µm, while the ice particles effective diameter ranged from 8 to 30 µm. The average effective diameters were 11 µm for water drops and 14 µm for frozen droplets. The deformation of the frozen droplets was evident during inspection under microscope; bulges and spikes protuberances were found in many of the observed ice particles. The results show that the aspect ratio of the frozen droplets is 1.2. To our best knowledge, this is the first laboratory work studying the representation of nonspherical ice crystals smaller than 30 mm in diameter.","palabras_clave":"SMALL ICE CRYSTALS|FROZEN DROPS|ASPECT RATIO|CRYSTAL SHAPES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89686,"idioma_id":4,"titulo":"Lightweight Approach to Connect Business Rules with Aspects","resumen":"Aspectual connection that compose business rule, refers to the code in charge of not only triggering the application of the rules at certain events, but also gathering the necessary information for their application and incorporating their results in the rest of the core application functionality. We propose an approach to connect business rule with aspect systematically. This approach is agile, programming language-independent, business rules type independent and it can be used in different stages of development. This approach considers the identification, analysis and construction of connections with aspects, (aspectual connection). We use our experience and previous works to define the initial steps, and complete them with the analysis of interactions and propose methods to implement aspectual connections code. We have developed a tool that supports this approach.","palabras_clave":"BUSINESS RULE|ASPECTUAL CONNECTIONS|INTERACTIONS|AOP|ASPECTJ"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89687,"idioma_id":4,"titulo":"Evaluation of cell behavior on modified polypropylene with swift heavy ion irradiation","resumen":"Ion beam irradiation is a well-known mean to change the physic-chemical properties of polymers, and induced bio and cytocompatibility in controlled conditions and in selected areas. However, the enhancement of cell adhesion on a modified substrate does not mean that the surface is adequate for functional cells. The purpose of the present work is to study proliferation, changes in cytoskeleton and cell morphology on substrates as a function of irradiation parameters. We irradiated polypropylene with sulfur (S) ion-beam at energies of 110 MeV with fluences between 1 x 106 and 2 x 1010 ions cm-2. NIH3T3 cells were cultured on each sample. Cell morphology was observed using phase contrast microscopy and cytoskeleton proteins with fluorescence microscopy. The analysis show different cellular responses as a function of irradiation parameter and strongly suggests that different underlying substratum can result in distinct types of cytoskeleton reorganization.","palabras_clave":"CELL ADHESION|BIOCOMPATIBILITY|IRRADIATED POLYMERS|SWIFT HEAVY IONS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89688,"idioma_id":4,"titulo":"Phosphorylation and Subcellular Localization of p27Kip1 Regulated by Hydrogen Peroxide Modulation in Cancer Cells","resumen":"The Cyclin-dependent kinase inhibitor 1B (p27Kip1) is a key protein in the decision between proliferation and cell cycle exit. Quiescent cells show nuclear p27Kip1, but this protein is exported to the cytoplasm in response to proliferating signals. We recently reported that catalase treatment increases the levels of p27Kip1 in vitro and in vivo in a murine model. In order to characterize and broaden these findings, we evaluated the regulation of p27Kip1 by hydrogen peroxide (H2O2) in human melanoma cells and melanocytes. We observed a high percentage of p27Kip1 positive nuclei in melanoma cells overexpressing or treated with exogenous catalase, while non-treated controls showed a cytoplasmic localization of p27Kip1. Then we studied the levels of p27Kip1 phosphorylated (p27p) at serine 10 (S10) and at threonine 198 (T198) because phosphorylation at these sites enables nuclear exportation of this protein, leading to accumulation and stabilization of p27pT198 in the cytoplasm. We demonstrated by western blot a decrease in p27pS10 and p27pT198 levels in response to H2O2 removal in melanoma cells, associated with nuclear p27Kip1. Melanocytes also exhibited nuclear p27Kip1 and lower levels of p27pS10 and p27pT198 than melanoma cells, which showed cytoplasmic p27Kip1. We also showed that the addition of H2O2 (0.1 µM) to melanoma cells arrested in G1 by serum starvation induces proliferation and increases the levels of p27pS10 and p27pT198 leading to cytoplasmic localization of p27Kip1. Nuclear localization and post-translational modifications of p27Kip1 were also demonstrated by catalase treatment of colorectal carcinoma and neuroblastoma cells, extending our findings to these other human cancer types.   In conclusion, we showed in the present work that H2O2 scavenging prevents nuclear exportation of p27Kip1, allowing cell cycle arrest, suggesting that cancer cells take advantage of their intrinsic pro-oxidant state to favor cytoplasmic localization of p27Kip1.","palabras_clave":"MELANOMA|P27KIP1|HYDROGEN PEROXIDE|CELL CYCLE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89689,"idioma_id":4,"titulo":"Voice Conversion Using K-Histograms and Residual Averaging","resumen":"The main goal of a voice conversion system is to modify the voice of a source speaker, in order to be perceived as if it had been uttered by another specific speaker.   Many approaches found in the literature convert only the features related to the vocal tract of the speaker. Our proposal is to convert those characteristics of the vocal tract, and also to process the signal passing through the vocal chords. Thus, the goal of this work is to obtain better scores in the voice conversion results.","palabras_clave":"Voice Conversion|k-histograms|Residual conversion|Signal Processing"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89690,"idioma_id":4,"titulo":"Geographic patterns and environmental drivers of flower and leaf variation in an endemic legume of Southern Patagonia","resumen":"Background: In widely distributed species, geographic patterns of phenotypic variation can appear in a clinal(linear or central?marginal) or mosaic fashion in response to environmental factors.  Aim: We assessed spatial patterns and possible abiotic drivers of &#64258;ower and leaf variation in Anarthrophyllum desideratum, an endemic legume found throughout a wide environmental gradient in southern Patagonia.  Methods: We measured 10 &#64258;oral and foliar traits from 26 populations, distributed along the entire range of the species. We examined phenotypic variation within and among populations, geographical patterns, relationships with climatic and edaphic factors and spatial covariation between &#64258;owers and leaves, using uni- and multivariate analyses.  Results: Most of the studied traits showed higher variability among than within populations. Within-population variability was not associated with population size. Phenotypic differences among populations were structured by geographic distances. Clinal variation patterns, mainly central?marginal, were detected along a south-west to north-east gradient. Flower and leaf size co-varied across populations, whereas, overall phenotypes were weakly coupled. Phenotypic variation was associated with temperature and soil potassium content.  Conclusions: Our results support geographically structured patterns of phenotypic variation and suggest that the abiotic environment has an important role in shaping &#64258;oral and foliar differences among A. desideratum populations. Non-stochastic processes may account for the geographical variation found in this species.","palabras_clave":"ANARTHROPHYLLUM DESIDERATUM|CENTRE-MARGIN DIFFERENTIATION|CLINAL PATTERN|GEOGRAPHIC STRUCTURE|FLOWER TRAITS|LEAF TRAITS|PRECIPITATION|SOIL CONDITIONS|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89691,"idioma_id":4,"titulo":"Conjugated linoleic acid is a preferential substrate for fatty acid nitration","resumen":"The oxidation and nitration of unsaturated fatty acids by oxides of nitrogen yield electrophilic derivatives that can modulate protein function via post-translational protein modifications. The biological mechanisms accounting for fatty acid nitration and the specific structural characteristics of products remain to be defined. Herein, conjugated linoleic acid (CLA) is identified as the primary endogenous substrate for fatty acid nitration in vitro and in vivo, yielding up to 10(5) greater extent of nitration products as compared with bis-allylic linoleic acid. Multiple enzymatic and cellular mechanisms account for CLA nitration, including reactions catalyzed by mitochondria, activated macrophages, and gastric acidification. Nitroalkene derivatives of CLA and their metabolites are detected in the plasma of healthy humans and are increased in tissues undergoing episodes of ischemia reperfusion. Dietary CLA and nitrite supplementation in rodents elevates NO(2)-CLA levels in plasma, urine, and tissues, which in turn induces heme oxygenase-1 (HO-1) expression in the colonic epithelium. These results affirm that metabolic and inflammatory reactions yield electrophilic products that can modulate adaptive cell signaling mechanisms.","palabras_clave":"FATTY ACID NITRATION|CONJUGATED LINOLEIC ACID|NITRATION|NITRITE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89692,"idioma_id":4,"titulo":"A macroscopic damage-plastic constitutive law for modeling quasi-brittle fracture and ductile behavior of concrete","resumen":"A new phenomenological macroscopic constitutive model for the numerical simulation of quasi-brittle fracture and ductile concrete behavior, under general triaxial stress conditions, is presented. The model is particularly addressed to simulate a wide range of confinement stress states, as also, to capture the strong influence of the mean stress value in the concrete failure mechanisms.The model is based on a two-surface damage-plastic formulation. The mechanical behavior in different domains of the stress space is  separately described by means of a quasi-brittle or ductile material response:(i) For positive values of the mean stress (tensile states), an isotropic continuum damage model with strain softening is considered. In this context, and in order to avoid the Boundary Value Problem ill-posedness induced by the softening law, a regularization technique based on the Continuum Strong Discontinuity Approach (CSDA) is adopted, which results equivalent to a damage model with embedded cohesive cracks providing anisotropic responses.(ii) A plastic model governs the material behavior when the mean stress is negative (confinement states). It is based on the classical plastic flow theory. In particular, a yield criterion similar to that of Willam and coauthors, which depends on the three stress invariants, is used. Additional features defining the plastic response are: an isotropic strain hardening law and a non-associative flow rule.The paper presents the numerical implementation of the model using an efficient integration algorithm, namely, the Impl-Ex scheme. Several widely known experimental tests (such as uniaxial, biaxial andtriaxial tests) carried out on concrete specimens are used to calibrate and validate the performance of the proposed formulation. Finally, a classical 2D reinforced concrete beam example is analyzed in order toshow the predictive capability of the model in structural analysis applications.","palabras_clave":"CONCRETE CONSTITUTIVE MODEL|CONCRETE FRACTURE|QUASI-BRITTLE DUCTILE FAILURE|STRONG DISCONTINUITY APPROACH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89693,"idioma_id":4,"titulo":"Production and characterization of sunflower (Helianthus annuus L.) protein enriched products obtained at pilot plant scale","resumen":"Sunflower protein  concentrates with different content of phenolic compounds were produced at  pilot plant scale from the by-product of oil manufacturing. The products obtained  were characterized, and their physicochemical properties (i.e. surface  hydrophobicity, thermal stability, and polypeptide composition) were evaluated at  different storage conditions. All the procedures evaluated resulted in  sunflower protein concentrates with high protein solubility (>60%) but with different  chemical composition, color, and physicochemical properties. The products  exhibited intense coloration and antioxidant properties due to their residual  phenolic compounds content. The addition of an isoelectric precipitation step increased  the protein content and the removal of phenolic compounds. The resulting concentrates  exhibited high protein digestibility in  vitro, even in the presence of phenolic compounds, and maintained high  protein solubility for at least 6 months of storage. During this period, only  structural changes in proteins were observed, as evidenced by their surface hydrophobicity.  The results demonstrate that it is feasible to produce sunflower protein  concentrates with high solubility on a pilot plant scale, using sunflower  oilcake as starting material.","palabras_clave":"sunflower protein concentrates|pilot plant scale|phenolic compounds|sunflower oilcake"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89694,"idioma_id":4,"titulo":"Study Of  EDTA Intake Of Children For Potential Use Of FeNaEDTA For Breakfast Cereal Fortification","resumen":"EDTA is used as disodium salt or disodiumcalcium in foods, to prevent lipid oxidation or as color and flavor stabilizer. In some countries, FeNaEDTA is also used as a source of iron for fortification. However, EDTA has an Acceptable Daily Intake (ADI) of 2.5 mg \/ kg\/day. The aim of this study was to estimate the intake of EDTA in children of school age and the potential use of Fe- NaEDTA as iron source for breakfast cereal fortification. A qualitative-quantitative food frequency questionnaire was conducted on 225 schoolchildren of both sexes, aged between 4 and 13, from school canteens, public and private schools, from the city of Santa Fe (Argentina). Only those foods which EDTA addition is allowed in Argentina: packaged ice cream, soda, soft drinks and powdered soft drinks (upper limit of Na2EDTA o Na2CaEDTA: 35 mg\/kg) and dressings and margarines (upper limit of Na2CaEDTA: 75 mg\/kg) were considered. EDTA Average Daily Consumption (ADC) was 0.06 mg\/kg\/day with a median of 0.011 mg\/kg\/day, representing 2.4% of the ADI. In the hypothetical case that FeNaEDTA would be used as iron source for breakfast cereal fortification at level of 11 mg Fe%, the potential EDTA ADC would be 0.46 ?E} 0.32 mg\/kg\/day, representing 18.4% of the ADI (2.5 mg\/kg\/day). Results indicate that children from Santa Fe city have an EDTA ADC currently well below the maximum ADI of EDTA, which would remain low even if FeNaEDTA is used for breakfast cereal fortification.2EDTA o Na2CaEDTA: 35 mg\/kg) and dressings and margarines (upper limit of Na2CaEDTA: 75 mg\/kg) were considered. EDTA Average Daily Consumption (ADC) was 0.06 mg\/kg\/day with a median of 0.011 mg\/kg\/day, representing 2.4% of the ADI. In the hypothetical case that FeNaEDTA would be used as iron source for breakfast cereal fortification at level of 11 mg Fe%, the potential EDTA ADC would be 0.46 ?E} 0.32 mg\/kg\/day, representing 18.4% of the ADI (2.5 mg\/kg\/day). Results indicate that children from Santa Fe city have an EDTA ADC currently well below the maximum ADI of EDTA, which would remain low even if FeNaEDTA is used for breakfast cereal fortification.","palabras_clave":"EDTA consumption|iron fortification|FeEDTA|breakfast cereals,"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89695,"idioma_id":4,"titulo":"X-rays as a tool for inducing variants of Calibrachoa","resumen":"The induction of mutations in the plant genome is an alternative method for breeding besides hybridization and transgenesis. This method can generate variation very quickly and decrease the time of the breeding process. The objective of the study was to evaluate two treatments using X-rays as a mutagenic agent in a selected clone of Calibrachoa (Solanaceae). This genus is South American with 11 native species in Argentina (Stehmann, 1999) and it has been recently introduced in the floricultural market. The Floriculture Institute (INTA-Castelar, Argentina) has initiated a breeding program with the aim to obtain agamic compact plants adapted to regional conditions. For this purpose, rooted cuttings (n=30) of a selected Calibrachoa material were irradiated with incremental doses and the LD50 was estimated for 24 Gy. Following these preliminary studies, rooted cuttings were exposed to: a) 1 irradiation event (24 Gy; acute dose) and b) 3 irradiation events (8Gy\/week; fractionated dose). The highest number of mutants was obtained with 3 exposure irradiation, thus the fractionated dose treatment was more effective than the acute dose treatment. We obtained mutants in colour and form in Calibrachoa flowers and a novel phenotype with ornamental aptitude for the ornamental market.","palabras_clave":"ACUTE DOSE|MUTATIONS|X-RAYS|LD50|FRACTIONATE DOSE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89696,"idioma_id":4,"titulo":"Mineral precipitation on modern siliciclastic tidal flats colonized by microbial mats","resumen":"The preservation and cementation of sedimentary structures under the influence of&nbsp; microorganisms in siliciclastic environments have been poorly studied in contrast to carbonatic settings, where they have been extensively investigated. Whereas in carbonatic environments, microbial mat-induced precipitation of calcium carbonate results in a cementation process producing a quick lithification, in siliciclastic environments other minerals would act as cement. The focus of this paper is to document the presence of authigenic minerals within a biosedimentary fabrics and the possible link of these minerals with the extensive microbial mats that colonize the tidal flat of the temperate Bahía Blanca estuary. ?Anoxic? minerals (e.g. pyrite) and authigenic zeolites such as analcime, clinoptilolite, mordenite, phillipsite and chabazite were recognized through SEM and EDX analyses. These minerals were most likely formed by alteration of volcanic ash, which is present in this tidal flat and also silica may result from dissolution of frustules of benthic diatoms. Minerals precipitated in this setting are significant as they would act as early cement in the eogenesis, enhancing the preservation of sedimentary and biogenic structures.","palabras_clave":"AUTHIGENIC MINERALS|ZEOLITES|BAHIA BLANCA ESTUARY|EARLY DIAGENESIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89697,"idioma_id":4,"titulo":"Microbially induced sedimentary structures in Neogene tidal flats from Argentina: Paleoenvironmental, stratigraphic and taphonomic implications","resumen":"Microbially induced sedimentary structures (MISS) result from the interaction betweenbenthic microorganisms and sediments; MISS preferably form in upper intertidal to supratidal settings from the Archean to the modern. The identification of MISS in Neogene deposits of the Rio Negro Formation (Late Miocene to Pliocene), Rio Negro Province, Argentina, covering the transition from continental to marine facies (and vice versa), provides the base to refine the palaeoenvironmental interpretation. The overall clastic paleocoast was differentiated into high-energy erosional domains and protected areas where MISS became preserved. However, during peak transgression also the initially protected areas experienced high energy sediment reworking. Because of the extent erosion in the high-energy coastal setting, the localized occurrence of tidal-flat deposits was difficult to recognize. The thin tidal flat deposits exhibit macroscopic and microscopic features that can be attributed to the interaction between microorganisms and sediment, such as cracks with upturned margins, sponge pore fabric, wrinkle structures, multidirected ripple marks, floating sand grains and so on. In addition, the biostabilization processes typical of substrates housing microbial mats led to the excellent preservation of vertebrate footprints that characterize these deposits.","palabras_clave":"MICROBIAL MATS|TIDAL FLATS|NEOGENE|VERTEBRATE FOOTPRINT TAPHONOMY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89698,"idioma_id":4,"titulo":"Study of the participation  of caffeine and polyphenols on the overall antioxidant activity of  Mate (Ilex paraguariensis.","resumen":"The aim of this work was to investigate the participation of the main bioactive compounds (caffeine, caffeic acid derivatives and rutin) on the antioxidant activity (DPPH free radical scavenging activity and the prevention of lipid peroxidation) of the crude extracts of Ilex paraguariensis. Green and commercial products were used to prepare aqueous extracts. The main bioactive compounds were identified and quantified by HPLC-DAD. The antioxidant activities of the pure compounds in the concentrations present in the extracts were also analyzed. Results demonstrated that chlorogenic acid, caffeic acid and rutin contribute to the antioxidant activity. On the contrary, caffeine induced lipid peroxidation of linoleic acid acting as a pro-oxidant compound. The caffeine content in the green extracts was lower when compared to the commercial extracts. The antioxidant and pro-oxidant antagonistic effects of the compounds in the amounts present in the extracts resulted in higher antioxidant potency of the green extracts when compared to the commercial ones, as demonstrated by the EC 50 values and without affecting the maximum efficiency displayed by the extracts.","palabras_clave":"Ilex paraguariensis|mate|polyphenols|antioxidant"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89699,"idioma_id":4,"titulo":"- Influence of Environment Conditions   on the Chemical Composition and Antioxidant Activity   of Larrea divaricata Aqueous Extract","resumen":"Natural antioxidants have gained considerable interest for their role in the prevention of autooxidation of fats and oils. Larrea divaricataCav. is a South American plant widely distributed in Argentina with reported antioxidant, antitumoral and antimicrobial activities. Theaqueous extract of the plant exerts antioxidant activity preventing the deleterious effect of temperature and oxygen on the antioxidantactivity of vitamin C (Vit C). The aim of this work was: to assess the stability of the aqueous extract of L. divaricata (AE) under differentenvironment conditions, such as different temperatures and air oxygen contents. The stability parameters evaluated included the percentageof majority compounds (flavonoid expressed as quercitrin (F) and nordihydroguaiaretic acid (NDGA)) and the antioxidant activity ofthe extract (AC). Results indicated that both compounds were affected by temperature and air oxygen, with F being more stable to hightemperatures than NDGA, finding a decrease of 56% for F and a decrease ¡Ý 66% for NDGA. Nevertheless, NDGA was more sensitive toair oxygen, as an early decrease of 62% and a maximum decrease of 100% were found. The AC of AE decreased with high temperatures;however, air oxygen seemed to have a more important effect, for a decrease of about 42% was observed after 7 days of incubation. Eventhough, the environment conditions could affect the chemical composition of the whole extract, it was observed that not all the compoundswere equally affected by temperature and air oxygen. Reaching a balance between these two parameters could allow a modulationof the antioxidant activity of this extract","palabras_clave":"LARREA DIVARICATA|AQUEOUS EXTRACT|ANTIOXIDANT ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89700,"idioma_id":4,"titulo":"Comparative Antiproliferative Action of Two Extracts from Tilia x viridis on Normal and Tumoral Lymphocytes: Rela-tionship with Antioxidant Activity","resumen":"Tilia species have been used in Asia, Europe and in America to treat anxiety and also for the treatment of colds and inflammation. The oxygen reactive species (ROS) (hydrogen peroxide (H2O2) and the superoxide anion (O2) are involved in the balance cell proliferation\/death in lymphocytes. It was reported the presence of flavonoids in Tilia species which possess antioxidant properties. The aim of this study was to determine comparatively the effect of an aqueous (AE) and ethanol (E) extract from Tilia x viridis, on the proliferation of tumoral and normal concanavalin A stimulated murine lymphocytes in relation to antioxidant activities such as peroxidase (Px), catalase (CAT) and superoxide dismutase (SOD) activities involved in H2O2 modulation. Also a phytochemical pattern of the two extracts in relation to flavonoids content was determined. Both extracts presented antiproliferative action on both types of lymphocytes but E was more selective on the tumoral lymphocytes inhibition (EC50 (ug\/ml, Mean ±SEM) (tumoral): 50 ± 4: EC50; (normal lymphocytes): 323 ± 20); this action was related to a high polyphenols content (150 ± 10 mg\/g extract) and high \u201Cper se\u201D SOD and low Px activities. In conclusion, the extracts could be a source of antioxidant compounds which contribute to a selective antiproliferative action on tumoral cells, acting through the modulation of H2O2 levels.","palabras_clave":"ANTIOXIDANT ACTIVITY|ANTIPROLIFERATIVE ACTIVITY|Tilia x viridis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89701,"idioma_id":4,"titulo":"Post-Fertilization Barriers in Interspecific Crosses between Nierembergia linariaefolia and N. ericoides","resumen":"In the present study we report the interspecific compatibility as a breeding tool to produce novel ornamental varieties in Nierembergia. Two species were used in reciprocal crosses, N. ericoides and N. linariaefolia. Interspecific crosses were carried out in spring. Ovary development, seed set for fruit and preliminary embryo development study was evaluated. Ovary showed normal development, when N. linariaefolia was used as pollen donor, and no significant differences in seed number were found with the control (N. ericoides × N. scoparia). Unlike, when N. ericoides was used as pollen donor, ovary carried on growing until 5 DPP (Day Post Pollination). Embryo development study revealed the normal gamete fusion, but zygote abortions were observed at 6 DPP in both reciprocal crosses. The result showed the incompatibility is caused by post-fertilization barriers. In addition, different characteristics in failure seed were observed, through embryo development study, between the reciprocal crosses.","palabras_clave":"EMBRYO DEVELOPMENT  |ZYGOTE ABORTION|POST-ZYGOTIB BARRIERS|INTERSPECIFIC INCOMPATIBILITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89702,"idioma_id":4,"titulo":"Surface water and groundwater characteristics in the wetlands of the Ajo River (Argentina)","resumen":"Intertidal wetlands are complex hydrological environments in which surface water and groundwater interact periodically with tidal flows. This work analyzes how the tidal flow determines the hydrodynamics and salinity of surface water and groundwater at different depths in the intertidal wetland located in the marsh of the Ajó River . Water level and salinity measurements were obtained from the Ajó River, the channels discharging into the river and the phreatic aquifer. The results in the natural marsh indicate the presence of saline stratification and that the surface water?groundwater relationship varies with the tide. At low tide, the water table discharges into the surface watercourses, and when the high tide rises above the regional groundwater discharge level, the tidal flow contributes to the water table, which causes an increase in salinity in surface water and groundwater. When the high tide does not rise above the discharge level, the tidal flow only enters the groundwater at the mouth section and the salinity of the surface water and groundwater decreases from low tide to high tide. In the marsh areas excluded from the tidal cycle due to the presence of floodgates, the water table always discharges into the canals, and in the surface water and groundwater there is no presence of saline stratification. The results obtained make it possible to generate a conceptual model of hydrological behaviour which shows the hydrodynamic and hydrochemical complexity of intertidal wetlands.","palabras_clave":"MARSH|SURFACE WATER |GROUNDWATER|SALT WATER INTRUSION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89703,"idioma_id":4,"titulo":"Relationship between precipitation and water-table fluctuation in a coastal dune aquifer: northeastern coast of the Buenos Aires province, Argentina","resumen":"The water-table fluctuation (WTF) method is one of the most widely used means to estimate aquifer recharge. In the northeastern coast of the Buenos Aires province, Argentina, the geomorphological and climatic characteristics, as well as the presence of a shallow, homogeneous unconfined aquifer, make it possible to apply this methodology. The relationship between water-table fluctuations and precipitation in a humid climate, considering its seasonal variations, is assessed. Water tables were measured monthly between February 2008 and September 2010 in a monitoring network; rainfall data were analysed. An increase in the water table occurs when the accumulated precipitation between measurements is above 53 mm\/month in the dry season and above 97 mm\/month in the rainy season. The index, relating water-table fluctuations and precipitation occurring between measurements, shows that values below 0 suggest no increase in the water reserves, whereas higher values entail an increase. In the study area, where there is a lack of historical data, finding out the relationship between water-table fluctuations and precipitation will constitute a tool for groundwater use and management, and to set up an early warning system for dry periods. It could also be extrapolated to other regions with similar hydrological conditions lacking in data.&nbsp;","palabras_clave":"groundwater recharge\/water budget|coastal aquifers|groundwater management|water-resources conservation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89704,"idioma_id":4,"titulo":"TEMPERATURE AND HUMIDITY INFLUENCES ON THE ON-SITE ACTIVE MARINE CORROSION OF REINFORCED CONCRETE ELEMENTS","resumen":"Reinforcement corrosion is a main durability issue for reinforced concrete structures in the marine environment. Environmental actions on the corrosion rate have been documented by several researchers on actively corroding reinforced concrete structures. Therefore, considering the influences of ambient temperature and relative humidity is very important for prospective studies of corroding structures. In this paper, active corrosion of concrete members in the marine environment was observed for 4.8&nbsp;years, and a relationship between the corrosion rate and ambient temperature and relative humidity is modeled. This very simple proposal is presented as a complementary tool to experimental measurements when assessing the deterioration rate of concrete structures in the marine environment.","palabras_clave":"REINFORCED CONCRETE|CORROSION|CHLORIDE|TEMPERATURE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89705,"idioma_id":4,"titulo":"B Chromosomes in the Tree Frog Hypsiboas albopunctatus (Anura: Hylidae)","resumen":"Supernumerary or B chromosomes are one of the main causes for numerical chromosomal variation in higher eukaryotes. These extragenetic elements have been studied for more than a century, with the goal of trying to understand their origin, and how they survive as a polymorphism in natural populations. Hypsiboas albopunctatus is a nocturnal hylid frog distributed in the central\u2013eastern part of South America. Previously, variation in chromosome numbers was described for a population from Rio Claro, São Paulo, Brazil, in which a single small-sized, metacentric B chromosome was present in ca. 40% of the analyzed individuals (n = 17). We herein describe the presence of B chromosomes in populations of H. albopunctatus from northeastern Argentina (Corrientes and Misiones provinces), with unusual morphological and structural characteristics. The frequency of B chromosomes varied significantly among analyzed populations. We found four diploid numbers (2N = 22, 22 + 1B, 22 + 2B, and 22 + 3B), and in a few individuals mitotic instability occurred. C banding revealed variations in the heterochromatin (DAPI+) pattern between Bs with similar morphology, indicating the existence of two new structural variants of these supernumerary elements in H. albopunctatus (B1 and B2). Nucleolar organizer regions marked positively on the eighth pair, coincident with the location of ribosomal DNA as demonstrated with fluorescent in situ hybridization, but Bs did not mark positive with these two techniques. Also, fluorescent in situ hybridization with telomeric probes showed no differences in location and intensity between Bs and autosomal chromosomes. The present communication is the first case of B chromosome polymorphisms in hylid frogs and the sixth reported in Anura.","palabras_clave":"FISH|Hypsiboas albopunctatus|Polymorphism|Supernumerary chromosome"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89706,"idioma_id":4,"titulo":"Osteological description of Pseudopaludicola canga with implications for the taxonomic position of this taxon","resumen":"Pseudopaludicola canga was described by Giaretta &amp; Kokubum (2003) based on 74 individuals previously assigned to P. mystacalis by Lobo (1995). In the diagnosis of P.&nbsp; canga, the original authors assigned the presence of terminal T-shaped phalanges as a character state for this taxon. However, the osteology of P. canga is not described and the presence of toe tips not expanded laterally is a characteristic share with all members of Pseudopaludicola unassigned to any group. In this work is describe for first time the osteology of P. canga, re-examining the external morphology providing a new diagnosisand establishing the taxonomic position of P. canga in the framework of phylogenetic hypothesis proposed by Lobo (1995). Additionally, is compared the toe tip digit IV, between P. falcipes and all the species included in the P. pusilla group and updated the type locality of P. canga. The osteology reveals that P. canga has the toe tips not T-shaped as mentionedby the original authors and this characteristic has important consequences for the diagnosis of the species. Additionally, the erroneous inclusion of P. canga in the P. pusilla group is confirmed by the phylogenetic analysis.","palabras_clave":"Pseudopaludicola pusilla group|osteology|external morphology|taxonomy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89707,"idioma_id":4,"titulo":"Hydrocarbon Yield Structure in the Conversion of Heavy Model Molecules (Quinolin-65) on Fluidized Catalytic Cracking Catalysts","resumen":"                    The reactivity of a heavy model molecule (quinolin-65, named Q65, a 2,3,7,8-dibenzopyrene derivative) over two different equilibrium fluidized catalytic cracking catalysts of the conventional and resid types was studied at 550 °C and with reaction times that varied from 5 to 20 s, in a batch fluidized-bed laboratory reactor. Two types of experiments were performed to determine the hydrocarbon products resulting from the conversion of Q65. This compound is solid at room temperature, and a solution of Q65 at 4.6 wt % in toluene and pure toluene were used. Conversions and yields were assessed by means of careful mass balances. The product distributions showed that Q65 produced a wide range of hydrocarbons from C1 to C20. These distributions were different according to the formulations of the catalysts. Olefins were predominant among gases and, neatly, aromatics among liquids. Coke yields were high, exceeding 12 wt %. The characteristics of the catalysts were also revealed through the higher activity and hydrogen-transfer ability of the conventional catalyst and the better coke selectivity of the resid catalyst. It was shown that both the linear alkyl chain and the multi-ring core react.","palabras_clave":"FCC|Resids|Q65|Fuels"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89708,"idioma_id":4,"titulo":"Root hydraulic conductance, aquaporins and plant growth promoting microorganisms: A revision","resumen":"A considerable number of soil and rhizospheric fungi and bacteria collectively known as plant growth promoting microorganisms (PGPM) have demonstrated ability to colonize plant roots and to provide benefits  to their hosts. Among these benefits, many authors documented improved root hydraulic conductance and alleviation of abiotic stresses such as drought and salinity. Today, it is accepted that movement  through aquaporins represents a quite faster pathway of water movement across biological membranes.  This review is intended to reflect the state of art in the knowledge of PGPM effects on plant water status and root hydraulic conductance, with special emphasis on the experimental data that prove or suggest  an impact of PGPM on root aquaporins under both normal and water limiting conditions.","palabras_clave":"aquaporins|plant growth promoting microorganisms|root hydraulic conductance|drought|salinity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89709,"idioma_id":4,"titulo":"Unravelling cadmium toxicity and tolerance in plants: Insight into regulatory mechanisms","resumen":"The occurrence of heavy metals in soils may be beneficial or toxic to the environment. The biota may require some of these elements considered essentials (like Fe, Zn, Cu or Mo) in trace quantities, but at higher concentrations they may be poisonous. Due to the difficulty in controlling environmental metal accumulation, organisms have to cope with exposure to unwanted chemical elements, specially those considered biologically nonessential. Cadmium (Cd) belongs to this latter group. The effect of Cd toxicity on plants has been largely explored regarding inhibition of growth processes and decrease of photosynthetic apparatus activity.","palabras_clave":"Cadmium Oxidative stress  |Heavy metals|Metal toxicity|Signalling|Gene regulation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89710,"idioma_id":4,"titulo":"Effects of fipronil on dogs over Triatoma infestans, the main vector of Trypanosoma cruzi, causative agent of Chagas disease","resumen":"Chagas disease is the most important endemic dis-  ease in Latin America, mainly transmitted by Triatoma infes-  tans in the Southern Cone countries of South America. Dogs  are one of themain domestic reservoirs of Trypanosoma cruzi,  the etiological agent of Chagas disease. The presence of dogs  in rural households of endemic areas significantly increases  the likelihood of the vectorial transmission of the parasite.We  studied the mortality and blood intake of T. infestans exposed  to dogs treated with different doses and formulations of  fipronil. Two doses, two formulations, and different  distances to the application point of fipronil were com-  pared. Third instar nymphs of T. infestans were fed at  different time intervals after the insecticide application  up to 45 days post-application. No significant difference  was found between the blood intake of nymphs fed on  control and treated dogs with different doses and formulations (p>0.05). The spray formulation showed low-  er effect and persistence than the spot-on formulation.  The mortality rate caused by the spot-on formulation in  the 26.8-mg active ingredient (a.i.)\/kg dose was higher  (48%)than with the 13.4-mg a.i.\/kg dose(25%),24h  after the insecticide application. The effect was highly  heterogeneous among replicates of the same treatment.  The mortality rate of nymphs fed over the point of the insecticide application was higher than the mortality of nymphs fed  over places 12 cm apart from the fipronil application point,  suggesting that the distribution of fipronil over the dog body is  lower than the needed one to obtain a persistent triatomicide  effect.","palabras_clave":"Triatoma infestans|Chagas disease|Fipronil|Vector control"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89711,"idioma_id":5,"titulo":"El Concejo Federal de Inversiones. Juan Quilici su primer presidente y los orígenes de las propuestas universitarias de integración regional y coordinación del desarrollo","resumen":"REVISTA INDEXADA EN LATINDEX, GUIA UICyT, y CAYCIT. El 29 de agosto de 1959, se aprobó la carta constitutiva del Consejo   Federal de Inversiones de la República Argentina (CFI), suscripto entre   las provincias argentinas, la Municipalidad de Buenos Aires y el   entonces, Territorio Nacional de Tierra del Fuego, Antártida e Islas del   Atlántico Sur. En esta ponencia se reseña la trayectoria de vida de   quién fuera desde entonces y hasta la caída del presidente Arturo   Frondizi, ministro de Hacienda de la provincia de Santa Fe, Juan A.   Quilici.  De esa manera se transita por la incidencia de la tradición   liberal de la ciudad de Rosario en los egresados de la Facultad de   Ciencias Económicas, Comerciales y Políticas de la Universidad Nacional   del Litoral (UNL), en la cuál él se formó, al integrar el primer   Instituto de Investigaciones Económicas. Asimismo se analiza su postura   dentro de las voces universitarias críticas a la realidad económica y   social del país que a partir de mediados de la década de 1930 se   manifestaron abiertamente a favor de la industrialización del país y de   la intervención del Estado en la ejecución y planificación de políticas   activas de desarrollo. Quilici, si bien tomará distancia de quienes   adhirieron políticamente al peronismo, coincidirá con los proyectos de   coordinación económica enunciada por el Gobierno para el Primer Plan   Quinquenal (1947-1952) y las posibilidades positivas que podía ofrecer   al país el Consejo Económico Nacional. En sus escritos, a partir de   1949, enfatizará en la implementación de un programa económico de   coordinación científica, para la descentralización económica y la   regionalización  de la Argentina. Quilici integró el grupo de jóvenes  profesionales que sin participación previa en la función pública   ocuparon cargos de relevancia en la vida académica y en la gestión   oficial, a partir de la caída del peronismo. Con la llegada al poder de   la Unión Cívica Radical Intransigente asumió la cartera de Hacienda de la provincia de Santa Fe, confiándosele a partir de la primera reunión de gobernadores de 1958 la organización e instrumentación del CFI, tarea para la que recurrió a egresados de la Facultad de Ciencias Económicas de la UNL, quienes participaron en la elaboración del borrador de la   carta constitutiva. Asimismo, esta ponencia procura analizar el escenario económico internacional, nacional y provincial en el cual el ministro Quilici llevó adelante su cometido, y los sugerentes debates sobre un renovado proyecto de nación propuestos por los mandatarios   provinciales y los ministros de Hacienda del período 1958-1960.","palabras_clave":"HISTORIA|ARGENTINA|DESARROLLO|REGIONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89712,"idioma_id":4,"titulo":"How good antioxidant is the red wine? comparison of some in vitro and in vivo methods to assess the antioxidant capacity of argentinean red wines","resumen":"There are many reports on the wine composition and their biological activities. However, to  our knowledge, there are no reports linking chemical composition and the protective effect from  oxidative stress on Saccharomyces cerevisiae. Our main goal was assessing the antioxidant capacity  (AC) of three Argentinean red wines (Cabernet Sauvignon, Malbec and Syrah) and its correlation with  polyphenols content (TP) and the phenolic profile. In vitro AC was measured by TEAC and FRAP  assays, while in vivo AC was measured using the eukaryote model Saccharomyces cerevisiae exposed  to H2O2 to induce oxidative stress. Three wine varieties showed significant AC both in vitro and in  vivo. Furthermore, we observed some protective effects of wine in cells exposed to H2O2, which was  correlated to the increased activity of antioxidant enzymes Glutathione peroxidase (GPx) and  Gluthatione reductase (GR). Cabernet Sauvignon showed higher AC than other varieties. We did not  observe significant correlation between TP content with AC, measured neither in vitro nor in vivo.  Conversely, canonical correlation and multiple regression analyses showed that AC is highly correlated  to their polyphenolic profile, with significant contribution of kaempferol and catechin. So far, our  current results point out the importance of analyzing the entire polyphenolic profile instead of TP in  addition to the use of in vivo assays to help understanding differences in AC of wines, which should be  extensive to other food products.","palabras_clave":"FOOD|WINE|ANTIOXIDANT|POLYPHENOLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89713,"idioma_id":4,"titulo":"Inhibition of the brain cytochrome  P450 aromatase isoform expression in Jenynsia multidentata reflects changes in water quality","resumen":"Cytochrome P450 aromatase is the steroidogenic enzyme that catalyzes the conversion of androgens to estrogens. Teleosts express two structurally and functionally different P450 aromatase isoforms, termed Cytochrome 19a1a and Cytochrome 19a1b. The first is preferentially expressed in ovary while the second is constitutively expressed in brain. The aim of the present study was to evaluate changes in cyp19a1b expression in brain of Jenynsia multidentata collected in Suquía river (Córdoba, Argentina) in order to assess if this biological response reflects changes in water quality.       For this purpose we first identified cyp19a1b parcial cDNA sequence and adjusted the method to quantify mRNA expression by qRT-PCR (quantitative RT-PCR). Then, water and fish samples were collected in five monitoring stations located along a pollution gradient in Suquía river. The qRT-PCR analysis of female brains reveals that cyp19a1b mRNA levels change as water pollution does, showing the highest levels at both unpolluted and recovered areas, with suppression as pollution increases.       Even when cyp19a1b expression in J. multidentata will need further studies, the results here presented indicate that this biological response appear as a promising biomarker of water pollution that may also point out the probable presence of endocrine disruptors.","palabras_clave":"Aromatase|Fish|Real Time RT-PCR|Water Pollution"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89714,"idioma_id":4,"titulo":"Long-term effect of tillage systems on soil microbiological, chemical and physical parameters and the incidence of charcoal rot (Macrohomina phaseolina) in soybean","resumen":"A 20-year field experiment was employed with the aim of evaluating the effect of tillage systems on biological, chemical and physical aspects of the soil, and to establish whether there was a correlation of these parameters with the incidence of charcoal rot (Macrophomina phaseolina) of soybean and crop yield. The tillage systems evaluated were direct seeding (DS), DS + scarifier (DS + S), minimum tillage (MT) and conventional tillage (CT). DS presented higher values than CT in culturable total fungi (26.33 × 105 vs. 2.33 × 105 CFU g&#8722;1 dry soil), total bacteria (182 × 107 vs. 64 × 107 CFU g&#8722;1 dry soil), microbial respiration (0.77 mg CO2 g&#8722;1 week&#8722;1 vs. 0.45 mg CO2 g&#8722;1 week&#8722;1) and fluorescein diacetate (FDA) hydrolysis (4.17 ug fluorescein g&#8722;1 h&#8722;1 vs. 1.70 ug fluorescein g&#8722;1 h&#8722;1 in CT. Fungal and bacterial community fingerprints, by terminal restriction fragment length polymorphism (T-RFLP) analysis, of Intergenic spacer regions of rRNA and 16S rRNA genes, respectively, were influenced by the tillage system. Also FAME (fatty acid methyl ester) profiles showed that microbial community structure in DS and CT was clearly different. DS samples contained significantly higher total microbial biomass than the other tillage treatments, but there were no significant differences in fungal biomass or any consistent trend with respect to stress index. Our results showed that microbial communities were more abundant and active in DS than in CT in response to high nutrient content in soil. Indeed, DS systems presented higher soil OM, total N, K and Ca than CT. Electrical conductivity and aggregate stability (AS) were also improved by DS. Soybean grown in high-quality soil was not affected by charcoal rot, however, under CT, disease incidence in soybean was 54%. These differences were correlated to the higher microbial abundance and activity under DS, the biological component being a key factor determining soil capacity to suppress the soilborne pathogen.","palabras_clave":"Soybean|Tillage systems|Microbial communities|T-RFLP|FAME|Soil quality|Soilborne fungi"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89715,"idioma_id":4,"titulo":"Binding of Carbonic Anhydrase IX to Extracellular Loop 4 of the NBCe1 Na+\/HCO3- Cotransporter Enhances NBCe1-mediated HCO3- Influx in the Rat Heart","resumen":"Na(+)\/HCO(3)(-) cotransporter (NBC)e1 catalyze the electrogenic movement of 1 Na(+):2 HCO(3)(-) into cardiomyocytes cytosol. NBC proteins associate with carbonic anhydrases (CA), CAII, and CAIV, forming a HCO(3)(-) transport metabolon. Herein, we examined the physical\/functional interaction of NBCe1 and transmembrane CAIX in cardiac muscle. NBCe1 and CAIX physical association was examined by coimmunoprecipitation, using rat ventricular lysates. NBCe1 coimmunoprecipitated with anti-CAIX antibody, indicating NBCe1 and CAIX interaction in the myocardium. Glutathione-S-transferase (GST) pull-down assays with predicted extracellular loops (EC) of NBCe1 revealed that NBCe1-EC4 mediated interaction with CAIX. Functional NBCe1\/CAIX interaction was examined using fluorescence measurements of BCECF in rat cardiomyocytes to monitor cytosolic pH. NBCe1 transport activity was evaluated after membrane depolarization with high extracellular K(+) in the presence or absence of the CA inhibitors, benzolamide (BZ; 100 &#956;M) or 6-ethoxyzolamide (ETZ; 100 &#956;M) (*P < 0.05). This depolarization protocol produced an intracellular pH (pH(i)) increase of 0.17 ± 0.01 (n = 11), which was inhibited by BZ (0.11 ± 0.02; n = 7) or ETZ (0.06 ± 0.01; n = 6). NBCe1 activity was also measured by changes of pH(i) in NBCe1-transfected human embryonic kidney 293 cells subjected to acid loads. Cotransfection of CAIX with NBCe1 increased the rate of pH(i) recovery (in mM\/min) by about fourfold (12.1 ± 0.8; n = 9) compared with cells expressing NBCe1 alone (3.1 ± 0.5; n = 7), which was inhibited by BZ (7.5 ± 0.3; n = 9). We demonstrated that CAIX forms a complex with EC4 of NBCe1, which activates NBCe1-mediated HCO(3)(-) influx in the myocardium. CAIX and NBCe1 have been linked to tumorigenesis and cardiac cell growth, respectively. Thus inhibition of CA activity might be useful to prevent activation of NBCe1 under these pathological conditions.","palabras_clave":"NBC|CARBONIC ANHIDRASE|METABOLON|HEART"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89716,"idioma_id":4,"titulo":"Integrability of nonlinear wave equations and solvability of their initial value problem","resumen":"We investigate one particular prototypical system of evolution equations in 1+1 dimensions, which models the (nonlocal) interaction of two waves in quadratic nonlinear media. These equations are integrable as they possess a Lax pair. We consider the spectral method of solving the associated initial value problem and, as recently pointed out, we show that generically the associated initial value problem cannot be linearized. We further elaborate on the integrability issue for this model by displaying the corresponding conservation laws and the motion of a particular soliton.","palabras_clave":"Integrability|wave equation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89717,"idioma_id":5,"titulo":"Iniciativas de Promoción de la Producción de TIC. Experiencias de \u201Ctecnopolos\u201D1 en Argentina","resumen":"En América Latina y Argentina han surgido, desde mitad del siglo XX, diversas iniciativas, en diferentes momentos históricos, de Parques, Polos, Incubadoras y Clusters Tecnológicos que si bien parten de construcciones teóricas distintas y de contextos económico-políticos diferentes, en la actualidad tales términos están siendo utilizados indistintamente para referenciar situaciones no asimilables. Mientras que los Parques y Polos han tenido como objetivo fomentar a nivel local y regional procesos de desarrollo de la innovación al considerar que los mismos facilitan y promueven la utilización productiva del conocimiento generado en el ámbito académico, los Clusters aparecen como instrumentos estratégicos de desarrollo y competitividad territorial. En este sentido, la importancia que la incorporación de conocimiento por parte de las empresas ha adquirido como clave para su desempeño exitoso, remonta la legitimación de este tipo de iniciativas a las características del nuevo modelo tecno-económico de crecimiento. En el trabajo, se analizan diversos procesos de promoción y producción de TIC en centros urbanos identificando las iniciativas de Parques, Polos y Clusters \u2013en su nueva resignificación-orientados a la producción de dichas tecnologías.","palabras_clave":"TERRITORIO|TECNOLOGÍAS DE INFORMACIÓN Y COMUNICACIÓN|UNIVERSIDADES Y SECTOR PRODUCTIVO|POLÍTICAS PÚBLICAS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89718,"idioma_id":5,"titulo":"Volcanismo de sin-rift de la Cuenca Neuquina, Argentina: relación con la  evolución Triásico Tardía-Jurásico Temprano del margen Andino","resumen":"Volcanismo de sin-rift de la Cuenca Neuquina, Argentina: relación con la evolución Triásico Tardía - Jurásico Temprano del margen Andino. La Cuenca Neuquina constituye uno de los rasgos más conspicuos desarrollados durante el Mesozoico en el margen poto-Andino de Gondwana. El relleno de sin-rift inicial (Triásico Superior-Jurásico Inferior) de esta cuenca extensional ensiálica estuvo caracterizado por una profusa actividad magmática. Los depocentros del sector austral de la cuenca (Chachil, Catán Lil, Chacaico, Sañicó y Piedra del Águila) muestran excelentes exposiciones para realizar el estudio de las rocas volcánicas representantes de este ciclo magmático. El presente análisis tuvo lugar mediante la caracterización estratigráfica, litológica y geoquímicas de las rocas volcánicas que componen hasta el 70% del total del relleno inicial. Las principales unidades volcánicas y piroclásticas son diques, domos, coladas, conductos emisores e ignimbritas. La distribución espacio-temporal de las diferentes unidades muestra una evolución desde términos efusivos de composiciones intermedias a términos piroclásticos ácidos, desarrollados hacia la parte superior de la secuencia. La caracterización litológica y petrográfica sugiere que el sistema volcánico estuvo asociado a reservorios magmáticos multinyectados, donde tuvieron lugar procesos típicos de cámaras magmáticas superficiales. El estudio de las facies de alteración de la secuencia reveló ocho tipos diferentes dentro del relleno de sin-rift, principalmente de carácter sin-volcánico y minoritariamente post-volcánico. El análisis geoquímico mostró el carácter co-genético de las rocas volcánicas y piroclásticas, con un dominio composicional desde términos intermedios a ácidos. Las rocas pertenecen a la serie subalcalina, mayoritariamente calcoalcalinas y transicionales, con patrones de elementos traza típicos de series orogénicas. Sin embargo muestran algunas diferencias evolutivas y composicionales (> 50% de términos diferenciados ácidos) con las series clásicas de arco. Los modelos actuales para generación de magmas en sistemas convergentes fueron discutidos (i.e. modelos de generación intra-corticales y extra-corticales), habiéndose optado por el modelo de generación extracortical para justificar los atributos composicionales y la evolución estratigráfica del Ciclo Precuyano. Este modelo implica la fusión parcial de un subplacado conformado por una \u201Cpluma silícica fría\u201D (i.e. mezcla de corteza oceánica y sedimentos provenientes de la losa subductada). El subplacado permitiría comprender la gran distribución del volcanismo Precuyano en sentido transversal al margen, mientras que en función del grado de fusión de la \u201Cpluma\u201D, se explicarían las composiciones dominantes del ciclo: andesíticas y dacíticas-riodacíticas. Durante el inicio de la extensión se habría favorecido el ascenso de materiales de composiciones intermedias, mientras que en el climax del rifting o en las zonas de mayor extensión se habría facilitado el ascenso de los materiales ácidos viscosos. Finalmente, un esquema de segmentación Andino a los 40° S explicaría el desarrollo de un segmento extensional, en donde se localizó la Cuenca Neuquina, y el desarrollo de un arco magmático hacia el sur, representado por el Batolito Subcordillerano.","palabras_clave":"CUENCA NEUQUINA|SYN-RIFT|VOLCANISMO|MARGEN ANDINO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89719,"idioma_id":5,"titulo":"Modelización matemática: Propuesta didáctica de articulación entre Matemática, Física y Geofísica","resumen":"El presente trabajo se halla inserto en el proyecto de investigación ?La Matemática como disciplina transversal en la formación de Licenciados en Geología? actualmente en ejecución en la Facultad de Tecnología y Ciencias Aplicadas de la Universidad Nacional de Catamarca. En este trabajo de articulación horizontal y vertical interdisciplinaria se ha escogido un tema de la asignatura Geofísica correspondiente a la rama denominada Sísmica. Este tema se considera importante por la aplicación regional, e interesante desde el punto de vista de las posibilidades de articulación con la Matemática y la Física; esta articulación se considera particularmente interesante en cuanto la asignatura Geofísica es común a las carreras de Licenciatura en Geología e Ingeniería de Minas. La búsqueda de la solución del problema de contexto a través de la modelación matemática constituye un proceso motivacional ? cognitivo que permite a los alumnos relacionar una situación real con los aspectos cualitativos del sistema físico y los conocimientos matemáticos necesarios para su resolución, proporcionando al estudiante una visión integradora de las Ciencias Básicas en su campo disciplinar específico. Los docentes de las diferentes áreas pueden usar una secuencia diferente a la propuesta, fortaleciendo el aprendizaje a través de las distintas formas de presentar esta articulación.","palabras_clave":"Modelado|Articulación"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89720,"idioma_id":4,"titulo":"Fault inversion vs new thrust generation: a case study in the Malargüe fold-and-thrust belt, Andes of Argentina","resumen":"Abstract    The reverse reactivation of pre-existing normal faults has been documented in many orogens. In other cases, the lack of subsurface information has allowed the construction of both inversion and non-inversion structural models. We will analyze the possibility of fault inversion in one such case, in the Malargüe fold-and-thrust belt in the Andes of Argentina. In order to address this issue, we modeled fault inversion vs. new thrust generation using the ReActiva 2.4 software, and varying the physical parameters for the pre-existing fault and the host rock. The results of modeling are compared to the possible sub-surface characteristics of faults in the Malargüe fold-and-thrust belt. We show that the orientation of these structures in the Andean stress field makes them likely to reactivate if the pre-existing fault planes present a low coefficient of friction and\/or fluid overpressure. Both are expectable in the geological setting in which the structures are found. We conclude that fault inversion cannot be dismissed, and should be taken into  22 account for structural models of the Malargüe fold-and-thrust belt. Our results can be extended to other orogens with similar characteristics.","palabras_clave":"Fault Inversion|Malargüe fold-and-thrust belt|Andes|Numerical modeling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89721,"idioma_id":4,"titulo":"Reply to L.V. Dimieri and M.M. Turienzo, 2012 comment on: 'Fault inversion vs. new thrust generation: A case study in the Malargüe fold-and thrust belt, Andes of Argentina' by J. F. Mescua and L. B. Giambiagi, Journal of Structural Geology 35 (2012) 51-63","resumen":"Sin resumen","palabras_clave":"Fault inversion|Malargüe fold-and-thrust belt|Andes|Numerical modeling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89722,"idioma_id":4,"titulo":"THRUST BELTS OF THE SOUTHERN CENTRAL ANDES: ALONG-STRIKE VARIATIONS IN SHORTENING, TOPOGRAPHY, CRUSTAL GEOMETRY, AND DENUDATION","resumen":"ABSTRACT  The Andean fold and thrust belts of west-central Argentina (33° and 36°S), above the normal subduction segment, present important along-strike variations in mean topographic uplift, structural elevation, amount and rate of shortening, and crustal thickness. To analyze the controlling factors of these latitudinal changes, we compare these parameters and the chronology of deformation along eleven balanced crustal cross-sections across the thrust belts between 70° and 69°W, where the majority of the upper crustal deformation is concentrated, and reconstruct the Moho geometry along the transects. We propose two models of crustal deformation. A 33°40´S model, where the locus of upper-crustal shortening is aligned with respect to the maximum crustal thickness, and a 35°40´S model, where the upper-crustal shortening is uncoupled from the lower-crustal deformation and thickening. This degree of coupling between  brittle upper crust and ductile lower crust deformation has strong influence on mean topographic elevation. In the northern sector of the study area, an initial thick and felsic crust favors the coupling model; while in the southern sector, a thin and mafic lower crust allows the uncoupling model.  Our results indicate that interplate dynamics may control the overall pattern of tectonic shortening, however local variations in mean topographic elevation, deformation styles and crustal root geometry are not fully explained and are more likely to be due upper-plate lithospheric strength variations.","palabras_clave":"Mountain building|Structural shortening|Topographic uplift|Tectonic evolution|Crustal deformation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89723,"idioma_id":4,"titulo":"A PHYSIOLOGICAL INDICATOR TO ESTIMATE ALLICIN CONTENT IN GARLIC DURING STORAGE","resumen":"The aim of the present work was to evaluate the application of a physiological indicator as marker of allicin content during postharvest storage at different temperatures. Sureño INTA garlic cultivar was stored at room temperature (20C  3) and cold storage (0C  0.5). Samples were taken periodically and allicin, pyruvate content were analyzed and the sprout growth was measured through of the visual index of dormancy (VID). The results showed that regardless of storage temperature, allicin,pyruvate content andVID changed significantly during the period of the assay. For the conditions evaluated, the highest allicin content was observed at 50% and 100%VID.These facts suggest thatVID may be a suitable tool to estimate allicin level during storage.","palabras_clave":"ALLICIN|GARLIC|POSTHARVEST|SPROUT GROWTH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89724,"idioma_id":4,"titulo":"Surface chemistry determines electron storage capabilities in alcoholic sols of titanium dioxide nanoparticles. A combined FTIR and room temperature EPR investigation","resumen":"Electron accumulation in TiO 2 ethanolic sols prepared by the HCl hydrolysis of a titanium alkoxide has been scrutinized by UV-vis and EPR spectroscopy. Unexpectedly, Ti(III) centers, g = 1.9551, formed after controlled monochromatic irradiation of the sols could be detected at room temperature by EPR spectroscopy. The yield of the paramagnetic signal and the number of accumulated reducing species, detected in dark titration experiments, increase as the water to titanium molar ratio, h, used in the synthesis diminishes. A 3.8% Ti(III) production efficiency was estimated for h = 6.5. Bidentate ethoxide coordination to the titanium dioxide surface and the replacement of surface hydroxylic groups by chloride ions is directly inferred by FTIR and EPR spectroscopies. Both findings are proposed to account for the room temperature detection of the Ti(III) species, and the higher electron storage capacity of the colloids prepared with lower h values.","palabras_clave":"Electron storage|EPR spectroscopy|Titanium dioxide nanoparticles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89725,"idioma_id":4,"titulo":"Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action","resumen":"Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on themRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor type 2 (TrKB), mitogen- activated protein kinases (MAPK\/ERK) and serotonin transporter (SERT). Animals treated with fluoxetine 10 mg\/Kg\/day for 28 days showed a significant decrease in the percentage of time spent in the novel object recognition test (p¡Ü0.005) and induced MAPK1\/ERK2 down-regulation (p=0.005). Our results suggest that the effect on cognition could probably be explained by fluoxetine interference in the MAPK\/ERK memory pathway. In contrast, chronic treatment with venlafaxine did not reduce MAPK1\/ERK2 expression, suggesting that MAPK1\/ERK2 down-regulation is not a common effect of all antidepressant drugs. Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance. ","palabras_clave":"fluoxetine|hippocampus|MAPK\/ERK expression|molecular memory pathway"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89726,"idioma_id":4,"titulo":"Up regulation of nitric oxide synthase-nitric oxide system in the testis of rats undergoing autoimmune orchitis","resumen":"Background: Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infiltrate of lymphomonocytes, producers of pro-inflammatory cytokines involved in germ cell apoptosis. Nitric oxide (NO), a free radical promoting immune cell activation and apoptosis, is synthesised by conversion of l-arginine to l-citrulline catalysed by NO synthase (NOS). The NOS isoforms are: constitutively endothelial (e) and neuronal (n) NOS and inducible (i) NOS.Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infiltrate of lymphomonocytes, producers of pro-inflammatory cytokines involved in germ cell apoptosis. Nitric oxide (NO), a free radical promoting immune cell activation and apoptosis, is synthesised by conversion of l-arginine to l-citrulline catalysed by NO synthase (NOS). The NOS isoforms are: constitutively endothelial (e) and neuronal (n) NOS and inducible (i) NOS.Objectives: Although the NO?NOS system was found to be up-regulated by pro-inflammatory mediators in immune and non immune testicular cells, data on its regulation in chronic inflammatory states is lacking.Although the NO?NOS system was found to be up-regulated by pro-inflammatory mediators in immune and non immune testicular cells, data on its regulation in chronic inflammatory states is lacking.Methods and results: EAO was induced in rats by active immunisation with spermatic antigens and adjuvants; control (C) rats were injected with adjuvants. Untreated normal (N) rats were also studied. We demonstrated that iNOS, eNOS and nNOS was mainly expressed by interstitial cells in N and C rats and that in EAO NOS was up-regulated and also expressed by tubular cells. Constitutive and inducible NOS content (Western blot) as well as NO production and activity increased in the testis of rats with EAO. iNOS content and activity were selectively up-regulated in the testis of rats with orchitis. Flow cytometric analysis of NOS isoforms in testicular macrophages (M) showed that the percentage of ED1+ED2&#8722; and ED1+ED2+ M subsets, expressing constitutive and iNOS isoforms was significantly higher in EAO, but no change in the percentage of ED1&#8722;ED2+ resident M was observed compared to C rats. M from EAO rats also released more NO than C and N rats.EAO was induced in rats by active immunisation with spermatic antigens and adjuvants; control (C) rats were injected with adjuvants. Untreated normal (N) rats were also studied. We demonstrated that iNOS, eNOS and nNOS was mainly expressed by interstitial cells in N and C rats and that in EAO NOS was up-regulated and also expressed by tubular cells. Constitutive and inducible NOS content (Western blot) as well as NO production and activity increased in the testis of rats with EAO. iNOS content and activity were selectively up-regulated in the testis of rats with orchitis. Flow cytometric analysis of NOS isoforms in testicular macrophages (M) showed that the percentage of ED1+ED2&#8722; and ED1+ED2+ M subsets, expressing constitutive and iNOS isoforms was significantly higher in EAO, but no change in the percentage of ED1&#8722;ED2+ resident M was observed compared to C rats. M from EAO rats also released more NO than C and N rats.Conclusions: In testis of rats with EAO, NO?NOS system was up-regulated and both testicular M and cells from seminiferous tubules contributed to NO increase. NO over production in orchitis was generated mainly by increased iNOS content and activity.In testis of rats with EAO, NO?NOS system was up-regulated and both testicular M and cells from seminiferous tubules contributed to NO increase. NO over production in orchitis was generated mainly by increased iNOS content and activity.","palabras_clave":"NITRIC OXIDE|NITRIC OXIDE SYNTHASE|EXPERIMENTAL AUTOIMMUNE ORCHITIS|MACROPHAGES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89727,"idioma_id":4,"titulo":"Experimental and mechanistic issues on the preparation of iron oxide nanoparticles stabilized","resumen":"Nanoparticles (NPs) with magnetic properties based on magnetite (Fe3O4, MAG) modified with oleic acid 27(OA), chitosan (CS) and bovine serum albumin (BSA) have been prepared. A versatile method of synthesis 28was employed, involving two steps: (i) co-precipitation of MAG; and (ii) nanoprecipitation of macromol- 29ecules on as-formed MAG NPs. Experimental variables have been explored to determine the set of con- 30ditions that ensure suitable properties of NPs in terms of their size, functionality and magnetic 31properties. It was found that the presence of OA in Fe+2\/Fe+3 solutions yields MAG NPs with lower aggre- 32gation levels, while increasing initial amounts of OA may change the capability of NPs to disperse in aque- 33ous or organic media by modifying the stabilization mechanism. Incorporation of CS was verified through 34Fourier transform IR spectroscopy. This biopolymer stabilizes NPs by electrostatic repulsions leading to 35stable ferrofluids and minimal fraction of recoverable solid NPs. BSA was successfully added to NP formu- 36lations, increasing their functionality and probably their biocompatibility. In this case too stable ferrofl- 37uids were obtained, where BSA acts as a polyelectrolyte. From the proposed methodology it is possible to 38achieve a wide range of NPs magnetically active intended for several applications. The required proper- 39ties may be obtained by varying experimental conditions.","palabras_clave":"MAGNETIC NANOPARTICLES |CO-PRECIPITATION|CHITOSAN|NANOPRECIPITATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89728,"idioma_id":4,"titulo":"Iodine-129 in animal thyroids from Argentina","resumen":"129I and 127I concentrations in animal thyroids coming from several regions of Argentina were determined by accelerator mass spectrometry (AMS) and gas chromatography (GC), respectively. The measured 129I\/127I ratios, ranging from 3×10&#8722;12 to 4×10&#8722;10, are significantly lower than those typical for areas in the northern hemisphere (10&#8722;10?10&#8722;7). The 129I concentrations show a clear dependence with latitude and season, which can be understood considering tropospheric circulation patterns, possible 129I sources and regional precipitation rates.","palabras_clave":"129I  |ACCELERATOR MASS SPECTROMETRY|ANIMAL THYROID |ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89729,"idioma_id":4,"titulo":"Improving Supply Chain Planning in a Competitive Environment","resumen":"This work extends the use of a Mixed Integer Linear Programming (MILP) model, devised to optimize the Supply Chain planning problem, for decision making in cooperative and\/or competitive scenarios, by integrating these models with the use of the Game Theory. The system developed is tested in a case study based in previously proposed Supply Chain, adapted to consider the operation of two different Supply Chains (multi-product production plants, storage centers, and distribution to the final consumers); two different optimization criteria are used to model both the Supply Chains benefits and the customer preferences, so both cooperative and non-cooperative way of working between both Supply Chains can be considered","palabras_clave":"Supply Chain planning|MILP-based model|Game Theory|Competitive Supply Chains"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89730,"idioma_id":4,"titulo":"An improvement based MILP optimization approach to complex AWS scheduling","resumen":"The Automated Wet-etch Station (AWS) is one of the most critical stages of a modern semiconductor manufacturing system (SMS), which has to simultaneously deal with many complex constraints and limited resources. Due to its inherent complexity, real-world automated wet-etch station scheduling problems are very difficult to solve using traditional mathematical formulations. Thus, heuristic, meta-heuristics and simulation-based methods have been reported in literature to provide feasible solutions with reasonable CPU times. This work presents an improvement MILP-based decomposition strategy that combines the benefits of a rigorous MILP (Mixed Integer Linear Programming) continuous-time formulation with the flexibility of dynamic heuristic procedures. The schedule generated provides near-optimal dynamic solutions to challenging industrial-sized automated wet-etch station scheduling problems with moderate computational cost. Also, this methodology provides more than a 7% of improvement in comparison with the best results reported in literature for the most complex problem instances analyzed. ","palabras_clave":"Hybrid decomposition approach|MILP-based strategies|Large-scale scheduling problems|Semiconductor Manufacturing System (SMS)|Wafer fabrication|Modeling and Optimization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89731,"idioma_id":4,"titulo":"Metabolic rate and food availability of the Antarctic amphipod Gondogeneia antarctica (Chevreux 1906): seasonal variation in allometric scaling and temperature dependence","resumen":"Among the few existing works on seasonal variation of metabolic rate of polar species, most have been conducted during summer due to logistic constraints, and have been focused on species that cease feeding during winter. In this work we present the first extensive data set on the seasonal variation of metabolic rate of G. antarctica, an abundant amphipod that feeds throughout the year, and its relationship with body size, potential food availability and temperature. We measured the resting metabolic rate (RMR) of groups of individuals during 6 months from late summer through winter at 4 experimental temperatures and for a wide range of body size. RMR had a negative allometric scaling with body size, and showed a tendency to increase with temperature as expected. However, temperature and body size effects on RMR showed a significant temporal variation, and an increase in temperature decreased scaling exponents. RMR at the mean seawater temperature throughout the study showed a strong seasonal variation following food availability: RMR decreased from the end of summer through winter, coinciding with a reduction in microphytobenthos stock, but recovered summer values in August, when an epontic algae boom occurred. The seasonal factorial aerobic scope (x2.37) is lower than benthic Antarctic invertebrates that cease feeding during winter, in agreement with what is expected based on theoretical grounds. Results suggest that seasonal variation of RMR would allow G. antarctica to achieve a high efficiency in energy utilization, while maintaining the ability to exploit sudden changes in food supply.","palabras_clave":"Seasonal metabolism |Food availability|Amphipod|Epontic algae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89732,"idioma_id":5,"titulo":"Relación entre el tipo de alojamiento y las respuestas de mirada, sociabilidad y miedo-apaciguamiento en perros","resumen":"El objetivo del presente artículo es estudiar si el alojamiento en refugios caninos altera las respuestas de mirar a la cara humana, el acercamiento y las conductas de miedo-apaciguamiento (cola y orejas bajas, agazapamiento) hacia una persona desconocida y si existe una relación entre estos comportamientos. Para ello se evaluaron ocho perros alojados por al menos dos años en un refugio y nueve perros de familia, adultos, mestizos y de ambos sexos en: 1. una prueba de sociabilidad consistente en la exposición a la presencia de una persona desconocida que se comporta de manera pasiva y 2. una tarea comunicativa, en la que una persona desconocida se coloca cerca de una fuente de comida que está a la vista pero inaccesible a los animales. Los resultados muestran que en ambas pruebas los perros de refugio mostraron mayores conductas de miedo-apaciguamiento hacia la persona, sin diferencias en sus respuestas de acercamiento. Tampoco se hallaron diferencias en la mirada a la cara humana. Sin embargo su duración fue mayor en ambos grupos en la tarea comunicativa, donde había comida, comparada con la prueba de sociabilidad. En conclusión el alojamiento en refugios alteraría algunas respuestas vinculadas al miedo-apaciguamiento, modificando la calidad del vínculo que puede establecerse entre ambas especies.","palabras_clave":"SOCIABILIDAD|MIEDO-APACIGUAMIENTO|COMUNICACIÓN|PERROS DE REFUGIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89733,"idioma_id":4,"titulo":"Mating success depends on rearing substrate in cactophilic Drosophila","resumen":"Drosophila buzzatii and D. koepferae coexist in the arid lands of southern SouthAmerica and exploit different types of cactus as breeding hosts. The former prefers tolay eggs on the rotting pads of prickly pears (genus Opuntia) whereas D. koepferaeexhibits greater acceptance for columnar cacti (e.g., Echinopsis terschekii). Here, wedemonstrate that the rearing cacti affect male mating success, flies reared in eachspecies´ preferred host exhibited enhanced mating success than those raised insecondary hosts. Opuntia sulphurea medium endows D. buzzatii males with greatermating ability while D. koepferae males perform better when flies develop in Echinopsisterschekii. These effects are not mediated through body size, even in D. buzzatiiwhose body size happens to be affected by the rearing cacti. This scenario, which isconsistent with the evolution of host specialization and speciation through sensorydrive, emphasizes the importance of habitat isolation in the coexistence of thesecactophilic Drosophila.","palabras_clave":"CACTUS HOST|HABITAT ISOLATION|HOST SPECIALIZATION|MATING SUCCESS|SENSORY DRIVE|SEXUAL SELECTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89734,"idioma_id":4,"titulo":"Host association of Spodoptera frugiperda (Lepidoptera: Noctuidae) corn and rice strains in Argentina, Brazil and Paraguay","resumen":"Spodoptera frugiperda (J.E. Smith) is composed of two genetically distinct strains, the so-called corn strain and the rice strain. Whether the two strains differ in their host use is unclear, because laboratory experiments have not been able to show consistent host performance or preference differences between them, and field studies showed high rates of hybridization, as well as some degree asymmetric host use. To determine the distribution of the two strains and their association with host plants, we collected fall armyworm larvae from different crops (corn, rice, alfalfa, and sorghum) and grasses in 15 different localities over 4 yr in Argentina, Brazil, and Paraguay. The strain identity was analyzed using two polymorphisms in the mitochondrial cytochrome oxidase subunit I gene. We identified the corn and rice haplotypes and three types of populations were characterized based on the frequencies of the individuals that belonged to any of these haplotypes: in 44% of populations the corn haplotype predominated, in 44% of populations the rice haplotype was the most frequent, and 11% of populations showed both haplotypes at similar proportions. In total, eight populations (47%) showed the expected pattern, two populations (12%) were polymorphic within the same field, and seven populations (41%) showed the inverse pattern. Taken together, there was no consistent pattern of host association between the two sympatric genotypes and their respective host plants. This investigation supports the need for additional studies to determine which other forces keep the genotypes separate, and what is the degree of genetic differentiation between these populations. &copy; 2012 Entomological Society of America.","palabras_clave":"fall armyworm|host race|PCR-restriction fragment-length polymorphism|cytochrome oxidase I"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89735,"idioma_id":4,"titulo":"An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes","resumen":"The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layer evaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellar vesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficiently into all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEG liposomal formulation showed the lowest aggregation value. The average diameter of liposomes with different lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differences between the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increased the stability of liposomes for at least 9 months. After a long storage, the most stable formulations were those without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values were higher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC) liposomes or Tween 80.","palabras_clave":"Liposomes|Phthalocyanines|Singlet oxygen|Stability"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89736,"idioma_id":4,"titulo":"Expression of a lipoxygenase encoding gene (BoLOX1) during postharvest senescence of broccoli","resumen":"Lipoxygenases (LOX) belong to a large family of plant enzymes that catalyze the hydroperoxidation ofpolyunsaturated fatty acids. Most of them are expressed during senescence and contribute to membranedeterioration and biosynthesis of jasmonic acid, a known senescence enhancer. In this work, we cloneda fragment of a gene encoding a LOX from broccoli (BoLOX1). The analysis of the sequence revealed thatBoLOX1 is closely related to other LOX from higher plants. Furthermore, we analyzed the expression ofBoLOX1 and detected a larger increase during postharvest senescence. A slight increase of total lipoxygenaseactivity was also found during senescence. In other sets of experiments, broccoli heads were treatedwith plant hormones, such as cytokinin and ethylene, as a way to assess the effect of such compoundson the expression of BoLOX1. Cytokinin treatment delayed the increase of BoLOX1 expression and lipoxygenaseactivity whereas ethylene accelerated both processes. Also, several postharvest treatments wereapplied in order to delay senescence in broccoli florets and to evaluate their effects on BoLOX1 expression.Samples treated with modified atmosphere, hot air, UV-C or white light showed a delay in chlorophylldegradation and degreening. In most cases, the treatments also delayed the increase of BoLOX1 expression,reaffirming the relationship between the expression of this gene and senescence. However, treatmentslike modified atmospheres and visible light markedly increased lipoxygenase activity, which suggests alack of correlation between BoLOX1 expression and lipoxygenase activity.","palabras_clave":"BROCCOLI|SENESCENCE|POSTHARVEST|LIPOXYGENASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89737,"idioma_id":4,"titulo":"Changes in membrane lipid composition cause alterations in epithelial cell-cell adhesion structures in renal papillary collecting duct cells","resumen":"In epithelial tissues, adherens junctions (AJ) mediate cell\u2013cell   adhesion by using proteins called E-cadherins, which span the plasma   membrane, contact E-cadherin on other cells and connect with the actin   cytoskeleton inside the cell. Although AJ protein complexes are inserted   in detergent-resistant membrane microdomains, the influence of membrane   lipid composition in the preservation of AJ structures has not been   extensively addressed. In the present work, we studied the contribution   of membrane lipids to the preservation of renal epithelial cell\u2013cell   adhesion structures. We biochemically characterized the lipid   composition of membranes containing AJ complexes. By using lipid   membrane-affecting agents, we found that such agents induced the   formation of new AJ protein-containing domains of different lipid   composition. By using both biochemical approaches and fluorescence   microscopy we demonstrated that the membrane phospholipid composition   plays an essential role in the in vivo maintenance of AJ structures   involved in cell\u2013cell adhesion structures in renal papillary collecting   duct cells.","palabras_clave":"ADHERENS JUNCTIONS|DETERGENT-RESISTANT MEMBRANE|RENAL PAPILLA|COLLECTING DUCT CELL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89738,"idioma_id":4,"titulo":"Glycosphingolipid synthesis is essential for MDCK cell differentiation","resumen":"Glycosphingolipids (GSLs), which are highly concentrated at the apical membrane of polarized epithelial cells, are key components of cell membranes and are involved in a large number of processes. Here, we investigated the ability of hypertonicity (high salt medium) to induce Madin\u2013Darby Canine Kidney (MDCK) cell differentiation and found an increase in GSL synthesis under hypertonic conditions. Then, we investigated the role of GSLs in MDCK cell differentiation induced by hypertonicity by using two approaches. First, cultured cells were depleted of GSLs by exposure to D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). Second, cells were transfected with an siRNA specific to glucosylceramide synthase, the key enzyme in GSL synthesis. Exposure of cells to both treatments resulted in the impairment of the development of the apical membrane domain and the formation of the primary cilium. Enzymatic inhibitions of the de novo and the salvage pathway of GSL synthesis were used to determine the source of ceramide responsible of the GSL increase involved in the development of the apical membrane domain induced by hypertonicity. The results from this study show that extracellular hypertonicity induces the development of a differentiated apical membrane in MDCK cells by performing a sphingolipid metabolic program that includes the formation of a specific pool of GSLs. The results suggest as precursor a specific pool of ceramides formed by activation of a Fumonisin B1-resistant ceramide synthase as a component of the salvage pathway.","palabras_clave":"GLYCOSPHINGOLIPIDS|HYPERTONICITY|CELL DIFFERENTIATION|APICAL MEMBRANE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89739,"idioma_id":4,"titulo":"Resistance induction in soybean: Phytoalexins determination","resumen":"The resistance induction, appears as a sustainable control strategy  in plants. The biosynthesis of phytoalexins is a relevant early response  in soybean (Glycine max)-pathogen interaction. This project  is related with the induction effect of chitosan, a glucosamine polymer.  The specific objective was: to develop a sensitive method for  phytoalexin determination in soybean leaves. Phytoalexins are extracted  by vacuum infiltration with aqueous 40% ethanol. The aqueous  phase was extracted with ethyl acetate and the organic phase  was dehydrated to dryness. Finally, it was measured the relative  intensity at 268 nm of ethanol dilution, applying 2nd Derivative  Spectrophotometry by using a HP 8452 diode array spectrophotometer.  A correlation coefficient r 0.9984 using genistein as standard,  was obtained. Soybean seeds 4990 from INTA (Argentina)  were soaked into chitosan 1 mg\/mL acetic acid pH 5.0 and control  assay. The growing plants were maintained three weeks in controlled  conditions. Phytoalexin level of 32 ±2 &#956;g\/g fresh leaves was found  in sample treated with chitosan, representing a 39% increase respect  to control. Two weeks later, an increase of 108% was registered.  This work allowed us to adjust the quantitative determination  of phytoalexins and to obtain preliminary results about chitosan  as inductor of phytoalexins biosynthesis in soybean leaves.","palabras_clave":"Soybean resistance|Induction|Phytoalexins|Chitosan"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89740,"idioma_id":4,"titulo":"Chlorpyrifos modifies the expression of genes involved in human placental function","resumen":"The effects of organophosphate pesticides on human placenta remain poorly investigated although anincreased risk of pregnancy alterations has been reported in women chronically exposed to these pesticides.Here, we have addressed whether chlorpyrifos (CPF) modifies the expression of genes relevantfor placental function. Human placental JEG-3 cells were exposed to increasing CPF concentrations up to100 M for 24 and 48 h and cell viability, mRNA, protein and hormone levels were analyzed. QuantitativeRT-PCR assays revealed that CPF increased the expression of ABCG2, GCM1 and, even more significantly,hCG mRNAs in conditions where cell viability and morphology were not compromised. In addition,hCG protein synthesis and secretion were time-dependently augmented. Present results may reflect aCPF nocive effect on placenta cells or a placental-defense mechanism to preserve its function. These novelCPF trophoblast target genes should be considered in future studies of pregnancy outcomes associatedwith in vivo exposures.","palabras_clave":"Organophosphate pesticide|Trophoblast|Gene expression|bhCG|Pregnancy"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89741,"idioma_id":4,"titulo":"Effects of the organophosphate insecticides phosmet and chlorpyrifos on trophoblast JEG-3 cell death, proliferation and inflammatory molecule production","resumen":"Epidemiological data have associated environmental organophosphate insecticide (OP) exposure during pregnancy with fetal growth deficits. To better understand OP injury that may adversely affect pregnancy, we used the JEG-3 choriocarcinoma cell line, which provide a recognized in vitro model to study placental function. The effects of the OP phosmet (Pm) and chlorpyrifos (Cp) on JEG-3 cells viability, proliferation, cell cycle and inflammatory molecule production were evaluated. Both insecticides affected cellular viability in a concentration- and time-dependent manner, inducing apoptosis and decreasing [3H]-thymidine incorporation. However, only Pm reduced DNA synthesis independently of cellular death and decreased the cell percentage at the S-phase. Unlike apoptosis, TNFa production varied with the concentration tested, suggesting that other TNFa independent mechanisms might trigger cell death. No induction of the inflammatory molecule nitric oxide was detected. The mRNA levels of proinflamatory IL-6, IL-17 and the antiinflammatory IL-13 cytokines were differentially modulated. These findings show that Pm and Cp generate a specific toxicity signature, altering cell viability and inducing an inflammatory cytokine profile, suggesting that trophoblasts may represent a possible target for OP adverse effects.","palabras_clave":"JEG-3 CELLS|ORGANOPHOSPHATE INSECTICIDES|CELL DEATH|INFLAMMATORY MOLECULES|TROPHOBLAST"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89742,"idioma_id":4,"titulo":"Environmental exposure to organophosphate pesticides: Assessment of endocrine disruption and hepatotoxicity in pregnant women","resumen":"In utero exposure is the first point of contact with environmental xenobiotics that may affect the  maternal-placental-fetal balance. Considering that maternal pathophysiological changes affect intrauterine  development, this pilot study was conducted to address how environmental exposure to  organophosphate pesticides (OPs) during pregnancy may contribute to maternal endocrine disruption  and disturbed hepatic function. A prospective study was carried out with pregnant women (n¼97)  living in a rural area of the Rio Negro province where OPs are intensively applied throughout 6 months  of the year. Blood samples were obtained and biomarkers of OPs exposure (cholinesterases and bglucuronidase),  cortisol (CT) and progesterone (PG) levels, as well as glycemia, were determined.  Parameters of liver injury were assayed by measuring aspartate aminotransferase (AST) and alanine  aminotransferase (ALT); liver function was assayed by measuring albumin. Biomonitoring carried out  during the pre-spraying period (PreS) and spraying period (SP) showed that the population studied was  exposed to OPs, proven by the fact that plasma (PCh) and erythrocyte cholinesterase (AChE) decreased  very significantly (po0.01) during SP. CT values increased very significantly (po0.01) in the first  trimester of pregnancy during SP with respect to PreS. Individual values above the upper limit of the CT  and PG reference range were found both in PreS and SP. This finding could be associated with changes  in hormone metabolism pathways produced by OPs exposure. During the second trimester of  pregnancy there were increases in ALT values and the AST\/ALT ratio in SP, suggesting subclinical  hepatotoxicity. In SP, glycemia was unchanged while albuminemia increased. Although anthropometric  newborn parameters and pregnancy alterations were within normal values for the general population,  the increase in CT in the maternal compartment may lead to impaired newborn health later in life.","palabras_clave":"ORGANOPHOSPHATES|ENDOCRINE DISRUPTION|PREGNANCY|CORTISOL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89743,"idioma_id":4,"titulo":". \u201CPlasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides\u201D,","resumen":"Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmentalorganophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact ofOP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy womenwho live in agricultural farms. Samples were collected during the pulverization period (PP) and recessperiod (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that womenwere exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increasedand the phosphatidylethanolamine content decreased in the light mitochondrial fraction while totalcholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggestrepair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicologicalimplications and thus entail potential risks to damage fetal growth and development.","palabras_clave":"Organophosphate pesticides|Carboxylesterase |Lipid composition|placenta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89744,"idioma_id":4,"titulo":"Environmental exposure to pesticides: biomarkers in non-invasively collected matrices in prenatal development and childhood","resumen":"The collection of invasive samples from susceptible populationsmay suffer from ethical and practical limitations that restrict the routine application of human biomonitoring. Moreover, the accumulation of exposure data will be unsuccessful in risk assessment if not integrated through the appropriate sets of biomarkers for early biological responses. This paper reviews the usefulness and limitations of non-invasively collected matrices as well as common and novel biomarkers of effect for evaluating the impact of environmental exposure to pesticides in periods of high susceptibility to toxicants. We conclude that in the prenatal period, placenta and umbilical cord blood are matrices with vast potential, as saliva is for childhood biomonitoring.Thus, the development of better technology and the use of novel approaches may be useful strategies. Prospective studies that integrate the information from different matrices obtained throughout pregnancy and childhood, and their association with childhood diseases, are advantageous.","palabras_clave":"PESTICIDES|BIOMARKERS|NON INVASIVE|PRENATAL DEVELOPMENT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89745,"idioma_id":4,"titulo":"Exact Packing measure of central Cantor sets in the line","resumen":"In this paper we consider a class of symmetric Cantor sets in $R$. Under certain separation condition we determine the exact packing measure of such a Cantor set through the computation of the lower density of the uniform probability measure supported on the set. With an additional restriction on the dimension we give also the exact centered Hausdorff measure by computing the upper density.","palabras_clave":"Cantor set|packing measure|hausdorff meausure|upper and lower density"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89746,"idioma_id":4,"titulo":"Trophoblast cells induce a tolerogenic profile in dendritic cells","resumen":"background: Dendritic cells (DCs), which are biased toward a tolerogenic profile, play a pivotal role in tissue-remodeling processes  and angiogenesis at the maternal\u2013fetal interface. Here, we analyzed the effect of trophoblast cells on the functional profile of DCs to gain  insight on the tolerogenic mechanisms underlying the human placental\u2013maternal dialog at early stages of gestation.  methods: DCs were differentiated from peripheral blood monocytes obtained from fertile women (n ¼ 21), in the presence of interleukin  (IL)-4 and granulocyte-macrophage colony-stimulating factor during 5 days in culture. Then, DCs were cultured with trophoblast cells  (Swan-71 cell line obtained from normal cytotrophoblast, at 7 weeks) for 24 h and for an additional 24 h in the absence or presence of lipopolysaccharide  (LPS) from Escherichia coli. DCs were recovered and used for flow cytometry, enzyme-linked immunosorbent assay, RT PCR  and suppression and migration assays.  results: Trophoblast cells significantly prevented the increase in CD83 expression induced by LPS without affecting the expression of  CD86, CD40 and human leukocyte antigen-DR (P , 0.05). Trophoblast cells signifinatly decreased the production of IL-12p70 and tumor  necrosis factor-a, while it increased the production of IL-10 (P , 0.05). No changes were observed in the production of IL-6 and monocyte  chemotactic protein-1. The culture of DCs with trophoblast cells, also suppressed the stimulation of the allogeneic response triggered by LPS  (P , 0.05). Conditioned DCs were able to increase the frequency of CD4 + CD25 + Foxp3 cells and this effect was accompanied by an  increase in indoleamine 2, 3-dioxygenase expression in DCs (P , 0.05).  conclusions: The interaction of DCs with trophoblast cells promotes the differentiation of DCs into cells with a predominantly tolerogenic  profile that could contribute to a tolerogenic microenvironment at the maternal fetal interface.","palabras_clave":"Dendritic cells|trophoblast|tolerance|immunity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89747,"idioma_id":4,"titulo":"The novel Solanum tuberosum calcium dependent protein kinase, StCDPK3, is expressed in actively growing organs","resumen":"Calcium-dependent protein kinases (CDPKs) are  key components of calcium regulated signaling cascades in  plants. In this work, isoform StCDPK3 from Solanum  tuberosum was studied and fully described. StCDPK3  encodes a 63 kDa protein with an N-terminal variable  domain (NTV), rich in prolines and glutamines, which presents  myristoylation and palmitoylation consensus sites and a  PEST sequence indicative of rapid protein degradation.  StCDPK3 gene (circa 11 kb) is localized in chromosome 3,  shares the eight exons and seven introns structure with other  isoforms from subgroup IIa and contains an additional intron  in the 50UTR region. StCDPK3 expression is ubiquitous  being transcripts more abundant in early elongating stolons  (ES), leaves and roots, however isoform specific antibodies  only detected the protein in leaf particulate extracts. The  recombinant 6xHis-StCDPK3 is an active kinase that differs  in its kinetic parameters and calcium requirements from  StCDPK1 and 2 isoforms. In vitro, StCDPK3 undergoesautophosphorylation regardless of the addition of calcium.  The StCDPK3 promoter region (circa 1,800 bp) was subcloned  by genome walking and fused to GUS. Light and  ABRE responsive elements were identified in the promoter  region as well as elements associated to expression in roots.  StCDPK3 expression was enhanced by ABA while GA  decreased it. Potato transgenic lines harboring StCDPK3  promoter::GUS construct were generated by Agrobacterium  tumefaciens mediated plant transformation. Promoter activity  was detected in leaves, root tips and branching points, early  ES, tuber eyes and developing sprouts indicating that  StCDPK3 is expressed in actively growing organs.","palabras_clave":"Calcium dependent protein kinases|Phytohormone responses|Signaling|Solanum tuberosum"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89748,"idioma_id":4,"titulo":"Changes on aggregates morphology and roughness induced by different uses of Typical Argiudolls, Buenos Aires province, Argentina","resumen":"Over the last few years, the increase of agriculture in the Pampean plains has led to a significant degradation of the most fertile soils in the country. The aim of our work is to define the effect of soil use on the stability of aggregates, bulk density and penetration resistance, and, especially, on the morphology and roughness of aggregates for their evaluation as possible soil quality indicators of Typical Argiudolls of south-eastern Buenos Aires. Mollic epipedons of plots with different soil use were analyzed: cultivated, pasture, and natural plots.The results indicated that bulk density values (>1.2 g\/cm3) and penetration resistance (2\u20134.4 MPa) values were significantly higher (p < 0.05) in the cultivated sites when compared to natural soil (1 g\/cm3 and 1.5\u20133 MPa respectively). Aggregate stability was significantly lower (p < 0.05) in the cultivated plots with respect to the natural plot, showing stable aggregates with values of 60\u201380% (crop intensive) and 85\u2013100% (crop extensive). Moreover, these areas showed a greater percentage of spherical aggregates, and less rough than those in the natural plots. All of the properties were affected by soil use. The morphology and roughness of aggregates are effective indicators to help in the evaluation the quality of Typical Argiudolls of south-eastern Buenos Aires.","palabras_clave":"EPIPEDON MOLIC|AGGREGATES CHARACTERIZATION|PRACTICE OF MANAGEMENT|SOILS QUALITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89749,"idioma_id":5,"titulo":"Aportes al conocimiento de las sociedades aldeanas  del período Temprano en la Quebrada de Humahuaca:  una visión desde Antumpa","resumen":"En este trabajo se presenta información acerca del componente Temprano o Formativo de Antumpa (departamento de Humahuaca, Jujuy). Este sitio es uno de los pocos conocidos para este rango temporal en la zona y, por ende, la información aquí aportada contribuye a profundizar el conocimiento disponible de las sociedades aldeanas que habitaron la región hacia el primer milenio de la era cristiana. En particular, se describen las excavaciones efectuadas en un montículo de origen cultural, en cuya base se identificó arquitectura temprana asociada a un nivel de ocupación. Se presenta una descripción de los materiales hallados en él, así como de los fechados radiocarbónicos obtenidos, que sitúan a la ocupación estudiada en la parte final del Período Temprano o Formativo. El conjunto artefactual presenta similitudes con los de otros sitios contemporáneos de la zona (e.g., cerámicas pulidas rojas y marrones, pipas cerámicas, puntas de proyectil pedunculadas pequeñas, palas\/azadas líticas), pero muestra también algunas peculiaridades (e.g., ausencia de la típica cerámica Gris Pulida; presencia de cerámica similar a la de tierras bajas salteñas) que podrían indicar modalidades culturales específicas del sector norte de la Quebrada de Humahuaca.","palabras_clave":"Período Temprano o Formativo|Quebrada de Humahuaca|Antumpa|Montículo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89750,"idioma_id":4,"titulo":"Macrophages activation by a purified fraction, free of nordihydroguaiaretic acid (NDGA), from Larrea divaricata Cav. as a potential novel therapy against Candida albicans","resumen":"Larrea divaricata Cav. (jarilla) is a plant with well-documented applications in Argentinean folk medicine. In order to determine if the treatment with a purified fraction named F1 was capable to maintain a state of priming of macrophages after 15 days of mice infection with Candida albicans. Infected and uninfected mice were used. The effect of F1 on: cytosolic protein levels, apoptosis, phagocytosis, reactive oxygen species production, nitric oxide (NO), cell activity, lysosomal activity and the tissue fungal burden were studied. The results showed that F1 increased macrophages yeast phagocytosis and reactive oxygen species and NO production. All these effects were related to a decrease of cell activity and possible apoptosis. In conclusion, it was observed that F1 could induce a state of long-term activation of macrophages, since we observed increased activity of macrophages 15 days after infection, and it could be related to the elimination of C. albicans. These data may suggest that F1 fraction could be useful against disseminated candidiasis in patients and further studies on this field are desirable.","palabras_clave":"Macrophages|Larrea divaricata Cav.|Candida albicans"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89751,"idioma_id":4,"titulo":"Talbot effect by a photorefractive volume phase grating","resumen":"In our proposal a light intensity distribution generated by an incoherently illuminated planar amplitude grating is projected into a photorefractive crystal. This 3D distribution is mapped as an index refractive perturbation via the photorefractive effect thereby generating a volume phase grating. The self-imaging phenomenon in the Fresnel field of this volume phase grating coherently illuminated is theoretically and experimentally analyzed. A model to simulate this volume grating that considers the 3D light intensity distribution formed in the crystal combined with the photorefractive grating formation theory is proposed. A path-integral approach to calculate the self-image patterns which account for the inhomogeneous propagation through the photorefractive grating is employed. The experimental and theoretical results show that the self-images location coincides with that of the self-images generated by planar phase grating of the same period. Moreover, the self-images visibility depends on three parameters: the exit pupil diameter of the incoherent recording optical system, the external electric field applied on the crystal and the crystal thickness. To study the visibility behavior, a phase parameter which includes the three mentioned parameters is proposed. The self-images visibility shows the typical sinusoidal dependence found in planar phase grating. A good agreement between theoretical and experimental results is observed.&nbsp; ","palabras_clave":"SELF IMAGING|VOLUME GRATING|PHOTOREFRACTIVE MEDIUM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89752,"idioma_id":4,"titulo":"COMPOSITION AND STRUCTURE OF HETEROPTERA COMMUNITIES (HEMIPTERA) IN HIGH ALTITUDE HABITATS OF A NATIONAL PROTECTED AREA IN ARGENTINA","resumen":"ABSTRACT: Composition and structure of Heteroptera communities (Insecta: Hemiptera) in high altitude habitats of a national protected area in Argentina. One of the basic strategies to protect biodiversity is the establishment of National Parks and other protected areas. Los Cardones National Park (Salta, Argentina) is of great importance because it attempts to preserve a representative sample of Andean biomes above 2700masl, such as Monte Occidental , the Puna-Prepuna and  upper reaches of  the  Yungas. We describe the composition and structure of  an inventory of true bugs sampled over a 1-year period in the three ecoregions represented in this protected area. Twenty-nine species of Heteroptera were recorded, including five new records for the Province of Salta. All species are first records to the park. The inventory obtained represents 85.29% of the total estimated by non-parametric estimator (Chao1), with Miridae as the best represented family. The results contribute to knowledge of the Heteroptera of the protected area and provide a basis for comparisons with other studies conducted in other high altitude habitats.","palabras_clave":"Biodiversity|true-bugs|Eco-regions"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89753,"idioma_id":4,"titulo":". Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins","resumen":"The need to develop novel antiviral agents encouraged us to assess the antiviral activity of synthetic sterol analogues with a diamide side chains. Cytotoxicity and antiviral activity of a family of azasterol previously synthesized was evaluated against herpes simplex virus 1 (HSV-1) (KOS and B2006) and vesicular stomatitis virus (VSV). This family of compounds was extended by the synthesis of novel analogs using an Ugi multicomponent reaction and their ability to inhibit viral multiplication was also evaluated. The results show that some of the compounds tested exert an antiviral activity. Besides, the effect of the azasterols on the intracellular localization of viral glycoproteins was examined. Strikingly, alteration on the glycoprotein D (gD) of HSV-1 fluorescence pattern was observed with both the antiherpetic compounds and the inactive azasterols.","palabras_clave":"AZASTEROL|UGI REACTION|ANTIVIRAL|HSV-1|VSV|GLYCOPROTEIN REACTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89754,"idioma_id":4,"titulo":"A survey of denitrifying Azospirillum brasilense in two contrasted conditions of the sugarcane cropping region of Tucumán, Argentina","resumen":"The aim of this work was the assessment of denitrifying Azospirillum brasilense isolates in two contrasted regions in the sugarcane cropping region of Tucumán, Argentina. For that, Azospirillum was isolated from the rhizoplane of sugarcane plants using nitrogen-free malate semisolid medium. Microbiological characteristics and restriction profiles of 16S rDNA indicated the presence of A. brasilense. PCR analysis of the isolates showed that the key enzyme for denitrification corresponded to the nitrite reductase type nirS. There were differences among the isolates in their physiological response to the nitrite reductase activity and the enzymatic restriction profiles of the nirS fragment. Differences among the isolates at genomic level were also assessed by RAPD method. According to the higher naturally occurrence of denitrifying Azospirillum in the wetter area of the sugarcane cropping region, our results suggest the existence of an influence of rainfall regime and soil characteristics in their environmental distribution. The knowledge of the ecology of denitrifiers (in this case, Azospirillum strains), represents a step forward to the rational utilization of microbial diversity in agriculture.","palabras_clave":"Azospirillum brasilense|denitrification|nitrite reductase|sugar cane"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89755,"idioma_id":5,"titulo":"Desarrollo, resistencia y cambio. Una mirada desde la Estepa rionegrina","resumen":"En este trabajo recorremos la noción de resistencia no violenta a partir de indagar en una experiencia rural de la estepa rionegrina. La iniciativa que analizamos pone en evidencia la necesidad de reconocer el contexto sobre el cual se plantea el ejercicio de resistencia, el modo en que el mismo se enclava en la revisión sobre la forma de considerar tres aspectos: la valoración e interpretación del espacio, la disputa a la política pública y la reconversión del orden familiar. Estos tres elementos, que superponen aspectos simbólicos con materiales, se debaten a partir de una propuesta de organización del comercio de producciones artesanales domésticas.  La noción de ?desarrollo? se descubre en los entramados de valores desde donde la reproducción de la subordinación asociada a esta idea, e incluso el desafío del cambio que está en la base de la propuesta, iluminan a la noción de ?resistencia no violenta?.","palabras_clave":"Desarrollo|Patagonia|Economía social|Producción artesanal doméstica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89756,"idioma_id":4,"titulo":"Phylogeographically concordant intraspecific cpDNA divergence in sympatric Nothofagus. How deep can it be?","resumen":"Here, we performed phylogenetic analyses and estimated the divergence times on mostly sympatric populations of five species within subgenus Nothofagus. We aimed to investigate whether phylogenetic relationships by nuclear internal transcribed spacer (ITS) and phylogeographic patterns by chloroplast DNA (cpDNA) mirror an ancient evolutionary history that was not erased by glacial eras. Extant species are restricted to Patagonia and share a pollen type that was formerly widespread in all southern land masses. Weak reproductive barriers exist among them.  Fifteen cpDNA haplotypes resulted from the analysis of three noncoding regions on 330 individuals with a total alignment of 1794 bp. Nuclear ITS data consisted of 822 bp. We found a deep cpDNA divergence dated 32 Ma at mid-latitudes of Patagonia that predates the phylogenetic divergence of extant taxa. Other more recent breaks by cpDNA occurred towards the north.  Complex paleogeographic features explain the genetic discontinuities. Long-lasting paleobasins and marine ingressions have impeded transoceanic dispersal during range expansion towards lower latitudes under cooler trends since the Oligocene.  Cycles of hybridization\u2013introgression among extant and extinct taxa have resulted in widespread chloroplast capture events. Our data suggest that Nothofagus biogeography will be resolved only if thorough phylogeographic analyses and molecular dating methods are applied using distinct genetic markers.","palabras_clave":"chloroplast capture|hybridization|introgression|Nothofagus|paleogeography|phylogeography|Tertiary|vicariance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89757,"idioma_id":4,"titulo":"Endothelial Lipase Activity Predicts High-Density Lipoprotein Catabolism in Hemodialysis : Novel Phospholipase Assay in Postheparin Human Plasma","resumen":"Objective: A novel phospholipase assay was used to measure for the first time the behavior of endothelial and hepatic phospholipase activities in postheparin human plasma of hemodialyzed patients and its relationship with atherogenic and antiatherogenic lipoprotein levels.Methods and Results:Endothelial and hepatic phospholipase activity was assessed in a total SN1-specific phospholipase assay, using (1-decanoylthio-1-deoxy-2-decanoyl-sn-glycero-3-phosphoryl) ethylene glycol as the substrate. Hemodialyzed patients presented lower values of total and hepatic phospholipase activity than controls: 4.4 (1.9?9.0) versus 7.5 (3.6?18.0) and 2.6 (0.7?6.2) versus 6.6 (1.3?15.2) &#956;mol of fatty acid released per milliliter of postheparin plasma per hour, respectively (P&lt;0.001); however, endothelial lipase (EL) phospholipase activity was increased in patients: 1.7 (0.8?3.0) versus 1.1 (0.1?2.7) &#956;mol of fatty acid released per milliliter of postheparin plasma per hour (P=0.008). EL was negatively associated with high-density lipoprotein (HDL)-cholesterol (r=?0.427; P=0.001), and apolipoprotein A-I levels, total phospholipase, and hepatic lipase activity were directly associated with low-density lipoprotein-cholesterol and apolipoprotein B. The association of EL and HDL-cholesterol remained significant when adjusting for waist circumference (&#946;=?0.26; P=0.05), and the effect of hepatic lipase on low-density lipoprotein-cholesterol continued after adjusting for age (&#946;=0.46; P= 0.001).Conclusion: Our results support the hypothesis that EL is the predominant enzyme responsible for lipolytic catabolism of HDLs in hemodialyzed patients and resolve the apparent paradox observed between low hepatic lipase activity and decreased HDL-cholesterol levels observed in these patients. In addition, the ability to assess total hepatic lipase and EL phospholipase activity in plasma will increase our knowledge of the mechanisms involved in controlling HDL levels and cardiovascular risk in hemodialyzed patients, as well as other populations with low levels of HDL-cholesterol.","palabras_clave":"CHRONIC KIDNEY DISEASE |ENDOTHELIAL LIPASE|HEPATIC LIPASE|HIGH DENSITY LIPOPROTEIN CHOLESTEROL|PHOSPHOLIPASE ACTIVITY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89758,"idioma_id":5,"titulo":"De las relaciones entre la estructura de las emociones, los discursos mediáticos y la denominada 'inseguridad'. Un análisis posible del tratamiento mediático del 'Caso Candela'","resumen":"Este artículo se propone problematizar el tratamiento mediático del denominado ?Caso Candela?, situando a éste en el marco de una construcción social del miedo y la inseguridad. A través de una mirada que privilegie una estructura social de las emociones y percepciones, nos proponemos analizar y describir los resortes afectivos que desde diferentes lugares y posicionamientos, brindan sostén a este tratamiento mediático. Consideramos necesario explicitar que este trabajo no apunta a discutir éticamente el rol de los medios en estos procesos. Buscaremos comprender y analizar la incidencia e impacto del tratamiento mediático en cuestión en la estructura social de emociones y percepciones. Nos proponemos, a su vez, desarrollar cómo este tratamiento se apoya en una particular configuración de las estructuras de las emociones, y a la vez, es parte constitutiva de su funcionamiento.","palabras_clave":"INSEGURIDAD|ESTRUCTURA DE LAS EMOCIONES|MEDIOS GRAFICOS|MIEDOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89759,"idioma_id":4,"titulo":"Effects of pretraining treatment with testosterone on  successive and anticipatory negative contrast","resumen":"Previous research indicated that the suppression of consummatory behavior that follows incentive downshift in male rats is attenuated by testosterone (T) administration during training. The present experiments were designed to assess the role of pretraining T administration on two incentive contrast situations in consummatory behavior: successive negative contrast (cSNC) and anticipatory negative contrast (cANC). In cSNC (Experiment 1), a downshift from 32% to 4% sucrose leads to behavioral suppression relative to an unshifted, 4% sucrose condition (the cSNC effect). Pretraining T administration enhanced consummatory behavior directed at 4% sucrose, without affecting behavior directed at 32% sucrose. This effect obscured a reduction in the cSNC effect by the T treatment that was only detected when a proportional measure of behavior was used. In cANC (Experiment 2), groups received access to two bottles per day separated by a short midtrial interval. Consumption of 4% sucrose is suppressed when the second bottle offers 32% sucrose, relative to 4% sucrose (the cANC effect). Pretraining T did not affect the cANC effect, known to be insensitive to treatment with anxiolytics. These results suggest an anxiolytic-like effect of testosterone in adjustment to incentive downshifts.","palabras_clave":"testosterone|consumatory successive negative contrast|consumatory anticipatory contrast |rats"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89760,"idioma_id":4,"titulo":"Polya-type polynomial inequalities in Orlicz spaces and best local approximation","resumen":"We obtain an extension of Pólya-type inequalities for univariate real polynomials in Orlicz spaces. We also give an application to a best local approximation problem.","palabras_clave":"ALGEBRAIC POLYNOMIALS|POLYA-TYPE INEQUALITIES|BEST LOCAL APPROXIMATION|BALANCED INTEGERS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89761,"idioma_id":4,"titulo":"Functional anatomy of the female reproductive systems of two spider crabs (Decapoda, Majoidea)","resumen":"In order to better understand the mating systems of majoid crabs, we studied the functional anatomy of the female reproductive systems of the spider crabs Leurocyclus tuberculosus and Libinia spinosa, comparing them with those of other Majoidea. Adult females were measured and dissected, and their reproductive systems described macroscopically and histologically. In females of both species, the seminal receptacles are paired globular structures of ecto-mesodermal origin. The mesoderm-derived region is lined by a stratified epithelium. The anchoring, proliferative, and secretory strata are clearly recognizable. The ectoderm-derived region is lined by a simple cylindrical epithelium underlying a cuticle that increases in thickness towards the vagina. The transition between the ectoderm- and mesoderm-derived regions is abrupt, with differences between the studied species: Li. spinosa has a \u201Cvelum\u201D, while Le. tuberculosus presents prominent \u201Cfolds\u201D. In both species, the position in which the oviduct is connected to the seminal receptacles is intermediate between the dorsal and ventral types previously described in other eubrachyurans. The seminal receptacles of the studied species show four different conditions, which can be distinguished macroscopically based on their shape and amount of sperm stored. We compare our data with those from other Majoidea in an attempt to determine whether the morphology of the seminal receptacles is related to different mating strategies or behaviors. ","palabras_clave":"MAJOIDEA|SEMINAL RECEPTACLES|LEUROCYCLUS TUBERCULOSUS|LIBINIA SPINOSA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89762,"idioma_id":4,"titulo":"Mathematical modeling of the heat transfer process and protein denaturation during the thermal treatment of Patagonian marine crabs","resumen":"Southern Ocean swimming crab Ovalipes trimaculatus and the Patagonian stone crab Platyxanthus patagonicus are fishing resources with commercial value. Thermal treatment of crabs is necessary to denature muscle proteins, facilitating meat detachment from the crab shell (picking procedure). The proximal composition, protein patterns of crab muscle, thermophysical properties and heat transfer coefficients were determined. Heat transfer during thermal processing of body (i.e., cephalothorax) and claws of both crab species was simulated using a finite element computational code; the simulations were experimentally validated. Color changes in crab muscle during the heating process were measured. Thermal denaturation kinetics of myofibrillar proteins was determined using Differential Scanning Calorimetry (DSC) in small samples previously heated in water under controlled conditions. DSC thermograms of raw crab muscle showed two peaks at 49.0 ± 0.4 and 77.5 ± 0.6 °C corresponding to myosin and actin respectively. Activation energies for the denaturation of myosin (145.70 kJ\/mol) and actin (156.42 kJ\/mol) were calculated from Arrhenius equation. The degree of denaturation achieved by the myofibrillar proteins at the coldest point of the muscle in body and claws during the heating process was established by considering the protein denaturation kinetics determined by DSC, the activation energies and the heat penetration curves. Adequate conditions for the detachment of meat from the crab exoskeleton were established. The obtained results may help in determining the optimal heating times during the industrialization of these crustaceans.","palabras_clave":"Marine crabs|Heat transfer|Finite element method|Mathematical model"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89763,"idioma_id":5,"titulo":"Simulación numerica del proceso industrial de congelación de cangrejos patagonicos","resumen":"La industria procesadora de carnes proveniente de cangrejos constituye una actividad incipiente en nuestro país. Una de las principales maneras en que pueden ser comercializados es como productos congelados. Por esta razón es importante conocer los tiempos de proceso, en particular se estudió la congelación de sistemas complejos tales como pulpa de cangrejo cocida envasada en películas plásticas al vacío y pinzas de cangrejo cocida que incluyen la lámina calcárea. Estos productos además de su geometría irregular presentan composición heterogénea multicapa (constituida por diversos materiales en serie). Para el estudio se tuvieron en cuenta las propiedades termofísicas del alimento, los coeficientes de transferencia de calor, la geometría del producto, temperatura del fluido externo, velocidades del aire. La simulación numérica del proceso de congelación permite estudiar el efecto de los parámetros como la temperatura y velocidad del aire refrigerante, la geometría del producto y su temperatura inicial. Asimismo, la geometría es importante cuando se requieren determinar los tiempos de congelación de manera precisa siendo el método de los elementos finitos la técnica numérica más útil para simular geometrías irregulares. Los objetivos del trabajo son: 1) determinar tiempos de congelación de pulpa y pinzas de cangrejo cocidas mediante la simulación numérica con elementos finitos y 2) validar los modelos con experimentos de congelación en túnel a escala industrial. Se congelaron muestras de los productos en túnel registrando las historias térmicas tanto en el producto como en el aire refrigerante. El contorno irregular del objeto se obtuvo mediante imágenes digitales. Se simuló numéricamente la temperatura en función del tiempo en todo el producto, especialmente en el punto más caliente. Se consideró el proceso de transferencia de energía conductivo en el producto y los coeficientes de transferencia de calor adecuados según la interfase considerada (contacto producto-placa metálica e interfase producto-aire). Las predicciones concordaron satisfactoriamente con resultados experimentales permitiendo determinar adecuadamente los tiempos de congelación. A partir de los resultados obtenidos se cuentan con las herramientas necesarias para aplicar la tecnología de congelación a productos que no han tenido aún desarrollo en nuestro país. ","palabras_clave":"Congelación|Simulación numérica|Resistencia en Serie|Cangrejos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89764,"idioma_id":4,"titulo":"Inequalities in L^{p-1} for the Extended L^p Best Approximation Operator","resumen":"The best polynomial approximation operator was recently extended byone of the authors from $L^p$ to $L^{p-1}.$ In this paper we studyweak and strong inequalities for maximal operators related with theextended best polynomial approximation operator. As an applicationwe obtain norm convergence of the coefficients of the bestpolynomial approximation.","palabras_clave":"Best approximation |Extension of the best approximation operator|Peano derivatives in $L^p$"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89765,"idioma_id":4,"titulo":"Isolation and characterization of a nucleopolyhedrovirus from Rachiplusia nu (Guenée) (Lepidopetra: Noctuidae)","resumen":"Rachiplusia nu (Guenée) (Lepidoptera: Noctuidae) is an important pest of vegetable crops widely distributed in South America. At present, its control is based on the use of broad spectrum chemical insecticides. In order to develop a more selective alternative to be applied in integrated or organic pest management programs, we isolated and characterized a baculovirus that infects R. nu, denominated RanuMNPV (Rachiplusia nu multiple nucleopolyhedrovirus) in view of its morphology and pattern of infection. According to optical microscope images of infected in vitro cell cultures, data from bioassays carried out with various species of larvae, and DNA sequences from p74, polyhedrin, v-cathepsin, v-chitinase, lef8 and lef9 genes, this isolate could be considered as a variant of Autographa californica MNPV with a different host range.                               ","palabras_clave":"RanuMNPV|AcMNPV|Host range"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89766,"idioma_id":4,"titulo":"EFFECTS OF NUTRITIONAL AND ANTI-NUTRITIONAL PROPERTIES OF SEEDS ON THE FEEDING ECOLOGY OF SEED-EATING BIRDS OF THE MONTE DESERT, ARGENTINA","resumen":"Food quality and physiological capacities and limitations in recognizing and processing food are among the factors influencing the choices of desert birds in feeding. Seed-eating birds of the central Monte desert  generally select grass seeds rather than forb seeds. We studied some of the mechanisms underlying seed-selection patterns in seed-eating birds of the Monte desert, analyzing nutrients and secondary compounds of the 15 most abundant seeds in the soil and their relationship with the diet of six species of seed-eating birds. Grass seeds contained more starch and less total phenols than did forb seeds and were free from alkaloids. The diet of the most graminivorous birds was correlated with seeds\u2019 starch concentration, while generalists\u2019 diet was correlated with seed abundance. To assess the plausible mechanisms underlying birds\u2019 selection of seed, we experimented with three species differing in the breadth of their diet: a generalist, the Rufous-collared Sparrow (Zonotrichia capensis), and two graminivores, the Many-colored Chaco-Finch (Saltatricula multicolor) and Common Diuca-Finch (Diuca diuca). We postulated that the level of starch and the presence of phenolic compounds and alkaloids influence food preference. Results suggest that most graminivorous birds prefer high-starch diets and avoid diets with  phenols and alkaloids. In contrast, the generalist foraged regardless of starch content, and its food intake was reduced Only by some of the phenols and alkaloids tested. Seed chemistry may explain some important features of seed selection by birds in the Monte desert.","palabras_clave":"ALKALOIDS|AVIAN FOOD CHOICE|DIET COMPOSITION|GRANIVORY|PHENOLS|SEEDS|STARCH"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89767,"idioma_id":4,"titulo":"Tolerance to Dietary Phenols and Diet Breadth in Three Seed-eating Birds: Implications to graminivory","resumen":"The ability to cope with plant secondary compounds (PSCs) has profound implications for an animal?s behavior. In the present study, we assessed the tolerance to dietary phenolics in three seed-eating birds: Zonotrichia capensis, Saltatricula multicolor and Diuca diuca which differ in their diet breadth. Seeds in their habitat have distinct chemical composition: grass seeds have less PSCs, specifically, less total phenolics than forb seeds. Based on the detoxification limitation hypothesis and using published data of the natural history of these birds in the central Monte desert, we postulate that predominantly and exclusively graminivorous birds such as D. diuca and S. multicolor respectively are less tolerant due, in part, to a lower detoxification capacity than those with greater diet breadth, Z. capensis. To achieve this goal, we measured the food intake of diets varying in their concentration of tannic acid (TA). Indicators of tolerance were body mass change, food, TA and water intake, and glucuronic acid output throughout the experiment. Zonotrichia capensis performed better along the tolerance experiment: it maintained body mass constant from 0% to 4% TA diet, food and TA intake were higher than the other two species at the end of the experiment, and also glucuronic acid output showed by Z. capensis was greater than D. diuca and S. multicolor from 2% TA diet until the end of the experiment. Our results suggest that Z. capensis is the most tolerant species and this physiological trait may explain their greater diet breadth.","palabras_clave":"phenols|phisiological tolerance"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89768,"idioma_id":4,"titulo":"Shadows of an absent partner: ATP hydrolysis and phosphoenzyme turnover of the Spf1 (sensitivity to Pichia farinosa killer toxin) P5-ATPase","resumen":"The P5-ATPases are important components of eukaryotic cells. They have been shown to influence protein biogenesis, folding, and transport. The knowledge of their biochemical properties is, however, limited, and the transported ions are still unknown. We expressed in Saccharomyces cerevisiae the yeast Spf1 P5A-ATPase containing the GFP fused at the N-terminal end. The GFP-Spf1 protein was localized in the yeast endoplasmic reticulum. Purified preparations of GFP-Spf1 hydrolyzed ATP at a rate of ~0.3-1 &#956;mol of P(i)\/mg\/min and formed a phosphoenzyme in a simple reaction medium containing no added metal ions except Mg(2+). No significant differences were found between the ATPase activity of GFP-Spf1 and recombinant Spf1. Omission of protease inhibitors from the purification buffers resulted in a high level of endogenous proteolysis at the C-terminal portion of the GFP-Spf1 molecule that abolished phosphoenzyme formation. The Mg(2+) dependence of the GFP-Spf1 ATPase was similar to that of other P-ATPases where Mg(2+) acts as a cofactor. The addition of Mn(2+) to the reaction medium decreased the ATPase activity. The enzyme manifested optimal activity at a near neutral pH. When chased by the addition of cold ATP, 90% of the phosphoenzyme remained stable after 5 s. In contrast, the phosphoenzyme rapidly decayed to less than 20% when chased for 3 s by the addition of ADP. The greater effect of ADP accelerating the disappearance of EP suggests that GFP-Spf1 accumulated the E1~P phosphoenzyme. This behavior may reflect a limiting countertransported substrate needed to promote turnover or a missing regulatory factor.","palabras_clave":"P5-ATPASE|SPF1|PARKINSON"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89769,"idioma_id":4,"titulo":"CHO  cells  expressing  the  human  P5-ATPase  ATP13A2  are  more  sensitive  to  the  toxic  effects  of  herbicide  Paraquat","resumen":"P-ATPases are membrane transporters energized by ATP. The subfamily of P5-ATPases is the least studied P-ATPases and the ion substrate specificity of the P5 subfamily is not known. Mutations of the human P5ATPase gene ATP13A2 has been shown to underlie a form of Parkinson disease (PD). We investigated the link between ATP13A2 and environmental factors related to PD development. Increasing concentrations of  the synthetic polyamine analog paraquat induced a greater cytotoxic effect over CHO cells expressing ATP13A2. Paraquat-toxicity was associated with increased production of cellular reactive oxygen species  and this increment was reversed by the natural polyamine spermidine. Acridine orange fluorescence intensity suggested that ATP13A2 induced the expansion of acidic vesicles that become more alkaline upon external addition of spermidine. Polyamine uptake is proposed to be initiated by a plasma membrane carrier followed by sequestration into acidic vesicles of the late endocytic compartment through an unidentified active mechanism; because ATP13A2 is located in lysosomes and late endosomes, our results open the possibility that ATP13A2 could be one of those active transporters capable of transporting polyamines like spermidine as well as its toxic analog paraquat.","palabras_clave":"P  TYPE  ATPASE|P5B  ATP13A2|PARAQUAT|PARKINSON|POLYAMINES|ACTIVE TRANSPORT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89770,"idioma_id":4,"titulo":"Microstructure of PP\/clay nanocomposites produced by shear induced injection moulding","resumen":"The maximum property enhancement in nanoclays reinforced polymers is obtained when high levels of intercalation, exfoliation and dispersion of the nanoclay in the polymer matrix is achieved. Processing of polymer nanocomposites by melt blending techniques requires sufficient stress levels and time for a maximum exfoliation\/intercalation of the nanoclays (with minimum polymer degradation), which both are very limited in conventional polymer processing techniques. Shear Controlled Orientation in Injection Moulding, SCORIM, is a non-conventional injection moulding  technique based on the concept of in-mould shear manipulation of the melt during the polymer solidification phase. This technique is able of applying high shearing levels to the polymer, leading to high levels of molecular orientation. SCORIM of nanoclay-based polymer nanocomposites may be therefore beneficial for achieving high levels of nanoclay  intercalation\/exfoliation and orientation, thus imparting improved mechanical properties. In this work, a nanoclay based masterbatch was mixed with polypropylene and direct injection moulded by conventional and SCORIM techniques. In SCORIM, two extreme shear levels were applied by changing processing conditions (melt temperature and shear time). We assess therefore the effect of high shear conditions in the levels of intercalation\/exfoliation and orientation of the nanoclay in the polymer matrix and in the mechanical properties of the nanocomposite. The levels of clay intercalation\/exfoliation were evaluated by Wide-Angle X-ray Scattering. The microstructure of the moulding was characterized by X-ray diffraction, polarized light microscopy and DSC. Besides influencing the nanoclay morphology, a strong coupling with the polymer morphology is also observed, evidencing the nanoclays as polymer morphology directors.","palabras_clave":"polypropylene|nanocomposites|injection molding|SCORIM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89771,"idioma_id":4,"titulo":"Differences in the sliding wear track patterns between UHMWPE\/steel and UHMWPE\/CNx pairs","resumen":"This work explores the effect of surface modification of stainless steel with a carbon nitride (CNx) film, under sliding wear of the UHMWPE\/steel. Wettatibility of CNx coatings is assessed by means of the sessile drop method using two different liquid media. Microhardness and stiffness of CNx coatings are estimated by depth-sensing indentation. The sliding performance of UHMWPE against stainless steel and CNx was evaluated using a pin on disk tribometer. It is demonstrated that CNx surface properties are quite different from those of stainless steel, with a concomitant substantial reduction of the coefficient of friction of UHMWPE\/CNx in comparison with the one of UHMWPE\/steel under sliding conditions. Even tough imposed sliding conditions do not conduct to wear mass loss in UHMWPE, wear track patterns against steel and CNx are quite different.","palabras_clave":"SLIDING WEAR|UHMWPE|CNx COATING"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89772,"idioma_id":4,"titulo":"A simple strain typing assay for trypanosoma cruzi: Discrimination of major evolutionary lineages from a single amplification product","resumen":"AbstractBackgroundTrypanosoma cruzi is the causative agent of Chagas' Disease. The parasite has a complex population structure, with six major evolutionary lineages, some of which have apparently resulted from ancestral hybridization events. Because there are important biological differences between these lineages, strain typing methods are essential to study the T. cruzi species. Currently, there are a number of typing methods available for T. cruzi, each with its own advantages and disadvantages. However, most of these methods are based on the amplification of a variable number of loci.Methodology\/Principal FindingsWe present a simple typing assay for T. cruzi, based on the amplification of a single polymorphic locus: the TcSC5D gene. When analyzing sequences from this gene (a putative lathosterol\/episterol oxidase) we observed a number of interesting polymorphic sites, including 1 tetra-allelic, and a number of informative tri- and bi-allelic SNPs. Furthermore, some of these SNPs were located within the recognition sequences of two commercially available restriction enzymes. A double digestion with these enzymes generates a unique restriction pattern that allows a simple classification of strains in six major groups, corresponding to DTUs TcI\u2013TcIV, the recently proposed Tcbat lineage, and TcV\/TcVI (as a group). Direct sequencing of the amplicon allows the classification of strains into seven groups, including the six currently recognized evolutionary lineages, by analyzing only a few discriminant polymorphic sites.Conclusions\/SignificanceBased on these findings we propose a simple typing assay for T. cruzi that requires a single PCR amplification followed either by restriction fragment length polymorphism analysis, or direct sequencing. In the panel of strains tested, the sequencing-based method displays equivalent inter-lineage resolution to recent multi- locus sequence typing assays. Due to their simplicity and low cost, the proposed assays represent a good alternative to rapidly screen strain collections, providing the cornerstone for the development of robust typing strategies.","palabras_clave":"TRYPANOSOMA CRUZI|STRAIN TYPING ASSAY|LINEAGE DISCRIMINATION|PCR-RFLP"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89773,"idioma_id":4,"titulo":"A genomic scale map of genetic diversity in Trypanosoma cruzi","resumen":"Abstract                 Background          Trypanosoma cruzi, the causal agent of Chagas Disease, affects more than 16 million people in Latin           America. The clinical outcome of the disease results from a complex interplay between           environmental factors and the genetic background of both the human host and the parasite.           However, knowledge of the genetic diversity of the parasite, is currently limited           to a number of highly studied loci. The availability of a number of genomes from different evolutionary lineages of           T. cruzi provides an unprecedented opportunity to look at the genetic diversity of the parasite           at a genomic scale.                  Results          Using a bioinformatic strategy, we have clustered T. cruzi sequence data available in the public domain and obtained multiple sequence alignments           in which one or two alleles from the reference CL-Brener were included. These data           covers 4 major evolutionary lineages (DTUs): TcI, TcII, TcIII, and the hybrid TcVI.           Using these set of alignments we have identified 288,957 high quality single nucleotide           polymorphisms and 1,480 indels. In a reduced re-sequencing study we were able to validate           ~ 97% of high-quality SNPs identified in 47 loci. Analysis of how these changes affect           encoded protein products showed a 0.77 ratio of synonymous to non-synonymous changes           in the T. cruzi genome. We observed 113 changes that introduce or remove a stop codon, some causing           significant functional changes, and a number of tri-allelic and tetra-allelic SNPs           that could be exploited in strain typing assays. Based on an analysis of the observed           nucleotide diversity we show that the T. cruzi genome contains a core set of genes that are under apparent purifying selection.           Interestingly, orthologs of known druggable targets show statistically significant           lower nucleotide diversity values.                  Conclusions          This study provides the first look at the genetic diversity of T. cruzi at a genomic scale. The analysis covers an estimated ~ 60% of the genetic diversity           present in the population, providing an essential resource for future studies on the           development of new drugs and diagnostics, for Chagas Disease. These data is available           through the TcSNP database (http:\/\/snps.tcruzi.org ).             ","palabras_clave":"TRYPANOSOMA CRUZI|GENETIC DIVERSITY|GENOMIC SCALE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89774,"idioma_id":4,"titulo":"Neonatal xenoestrogen exposure alters Growth hormone-dependent liver proteins and genes in  adult female rats","resumen":"Thehypothalamic-growthhormone (GH)\u2013liver axis represents anew conceptinendocrine regulationof  drug toxicity. Preponderant sex differences are found in liver gene expression, mostly dependent on the  sexually dimorphic pattern of GH secretion which is set during the neonatal period by gonadal steroids.  We tested if GH-dependent sexually dimorphic liver enzymes and proteins was perturbed by neonatal  BisphenolA(BPA)treatmentinfemalerats. Femaleratsweresc injectedwithBPA(50or500g\/50l)or  castoroilvehicle frompostnatalday1to10.At&#64257;vemonths serumprolactin,pituitaryGH, andserumand  liver insulin growth factor-I (IGF-I) were measured by RIA. Major urinary proteins (MUPs) were determined by electrophoresis. Liver Cyp2c11, Cyp2c12, Adh1, Hnf6, and Prlr mRNA levels were determined  by real time PCR. Pituitary GH content and liver IGF-I concentration were increased by neonatal BPA  treatment, indicating partial masculinization of the GH axis in treated females. GH-dependent female  predominant liver enzyme genes (Cyp2c12 and Adh1) and a transcription factor (Hnf6) were downregulated or defeminized, while there were no changes in a male predominant gene (Cyp2c11) or protein  (MUP). Our &#64257;ndings indicate that perinatal exposure to BPA may compromise the sexually dimorphic  capacity ofthe liver to metabolize drugs and steroids.","palabras_clave":"Growth hormone  |Cyps|Liver|Bisphenol|  Prolactin|Sexual dimorphism"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89775,"idioma_id":4,"titulo":"The Epidemiology of Mould Infections in Argentina: Review and Experience","resumen":"During the last decades, there has been an increasing proportion of patients susceptible to invasive fungal disease (IFD). The epidemiology of IFD varies mainly due to geography, antifungal exposure, and nosocomial reservoirs. We reviewed the Argentinean epidemiology of invasive mold disease (IMD) by analyzing laboratory and clinical data. Invasive mold disease was the second most prevalent IFD following the yeasts, with a prevalence that ranged from 0.98 to 1.31\/100,000 population. The majority (60?85&nbsp;%) of IMD was caused by hyalohyphomycetes followed by Mucorales (6?21&nbsp;%) and phaeohyphomycetes (7?13&nbsp;%). The most prevalent genera were Aspergillus (40?67&nbsp;% of IMD) followed by Fusarium (10?14&nbsp;%). The most prevalent species were A. fumigatus (38?50&nbsp;%) followed by A. flavus (27?43&nbsp;%). In immunocompromised patients in Argentina the most prevalent agents of IMD are Aspergillus, followed by Fusarium and Mucorales, while the most prevalent Aspergillus species are A. fumigatus followed by A. flavus.","palabras_clave":"Invasive fungal disease|Invasive mould disease|Epidemiology|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89776,"idioma_id":4,"titulo":"First Case Report of Bloodstream Infection Due to a Candida Species Closely Related to the Novel Species Candida pseudorugosa","resumen":"First Case Report of Bloodstream Infection Due to a Candida Species  Closely Related to the Novel Species Candida pseudorugosa  Constanza Giselle Taverna,a Susana Córdoba,a Guillermina Isla,a Norma Fernández,b Susana García,c Mariana Mazza,a  Omar Alejandro Murisengo,a Walter Vivot,a Wanda Szusz,a Graciela Davel,a Iris Nora Tiraboschi,b and María Eugenia Bosco-Borgeata  Departamento Micología, Instituto Nacional de Enfermedades Infecciosas \u201CDr. Carlos G. Malbrán,\u201D Ciudad Autónoma de Buenos Aires, Argentinaa; Sección Micología de la  División Infectología del Hospital de Clínicas \u201CJosé de San Martín,\u201D Ciudad Autónoma de Buenos Aires, Argentinab; and División Bacteriología, Departamento de  Bioquímica Clínica del Hospital de Clínicas \u201CJosé de San Martín,\u201D Ciudad Autónoma de Buenos Aires, Argentinac  Candida pseudorugosa is a novel species closely related to Candida rugosa for which only one case has been reported. We report  the first case of a bloodstream infection in humans caused by a Candida sp. closely related to C. pseudorugosa. We contribute  evidence to show this organism as a potential human pathogen that may be misidentified by conventional methods, also pointing  out its lower sensitivity to azoles and other antifungal agents.","palabras_clave":"CANDIDA PSEUDORUGOSA|BLOODSTREAM CANDIDA|PSEUDORUGOSA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89777,"idioma_id":4,"titulo":"Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency","resumen":"Examples of hormonal phase-shifting of circadian gene expression began to emerge a few years ago. Vitamin A fulfills a hormonal function by binding of retinoic acid to its nuclear receptors, RARs and RXRs. We found retinoid- as well as clock-responsive sites on regulatory regions of Glutathione reductase (GR) and Glutathione peroxidase (GPx) genes. Interestingly, we observed retinoid receptors, as well as GSH, GR and GPx, display daily oscillating patterns in the rat liver. We also found that feeding animals with a vitamin A-free diet, dampened daily rhythms of RAR&#945; and RXR&#946; mRNA, GR expression and activity, GSH, BMAL1 protein levels and locomotor activity. Differently, day-night oscillations of RXR&#945;, GPx mRNA levels and activity and PER1 protein levels, were phase-shifted in the liver of vitamin A-deficient rats. These observations would emphasize the importance of micronutrient vitamin A in the modulation of biological rhythms of GSH and cellular redox state in liver.","palabras_clave":"GLUTATHIONE|LIVER|VITAMIN A|BIOLOGICAL RHYTHM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89778,"idioma_id":4,"titulo":"Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens","resumen":"In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their&nbsp; straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries.","palabras_clave":"ACYLATED PEPTOIDS|MULTICOMPONENT REACTIONS|PLANT PATHOGEN|ANTIFUNGAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89779,"idioma_id":4,"titulo":"Effect of pulsed light combined with an antibrowning pretreatment on quality of fresh cut apple","resumen":"(AD) (ascorbic acid plus CaCl2 solution) and refrigerated storage on native microflora survival, color, rheological properties (oscillatory shear, creep\/recovery and double-compression tests), texture, micro and ultrastructureof cut apple. The anti-browning dipping was effective in inhibiting browning on apple surface exposed up to a PL dose of 71.6 J\/cm2 . Native microflora counts in stored samples treated with AD+ PL were lower than in non-treated apples. Changes in rheological properties due to treatments and\/or storagewere detected. They were mainly associated with a decrease in G?? and G?? and an increase in compliances J0, J1 and J2 and modifications of TPA parameters. The assessors only evidenced a slight decrease in juiciness and crispness in stored and\/or AD+ PL treated apples. Changes in rheological properties and texture werepartially correlated with structure features.Industrial relevance: During the last few decades, research on food preservation has focused on meeting consumer demands for more natural and healthier food, with the interest moving from conventional thermal treatments toward ?non-thermal? preservation techniques. Pulsed light is an emerging preservation factor that is being studied as an alternative process to decontaminate foods. This study contributes to evaluate the feasibility of pulsed light treatment to extend the shelf life of cut apple.","palabras_clave":"pulsed light|cut apple|antibrowning treatment|native flora|color|texture|rheology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89780,"idioma_id":4,"titulo":"Copper releasing boron containing bioactive glass derived 3D composite scaffolds coated with alginate for bone tissue engineering","resumen":"The aim of this study was to synthesize and characterize new boron-containing bioactive glass-based scaffolds coated with alginate cross-linked with copper ions. A recently developed bioactive glass powder with nominal composition (wt.%) 65 SiO2, 15 CaO, 18.4 Na2O, 0.1 MgO and 1.5 B2O3 was fabricated as porous scaffolds by the foam replica method. Scaffolds were alginate coated by dipping them in alginate solution. Scanning electron microscopy investigations indicated that the alginate effectively attached on the surface of the three-dimensional scaffolds leading to a homogeneous coating. It was confirmed that the scaffold structure remained amorphous after the sintering process and that the alginate coating improved the scaffold bioactivity and mechanical properties. Copper release studies showed that the alginate-coated scaffolds allowed controlled release of copper ions. The novel copper-releasing composite scaffolds represent promising candidates for bone regeneration.","palabras_clave":"BIOACTIVE GLASS|SCAFFOLDS|ALGINATE|CU ION RELEASE|ANTIBACTERIAL"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89781,"idioma_id":4,"titulo":"Bisphosphonate-based strategies for bone tissue engineering and orthopaedic implants","resumen":"Bisphosphonates (BPs) are a group of well-established drugs applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering which is the topic of this review in which an extensive overview of published studies on the development and applications of BPs based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three dimensional (3D) bone tissue scaffolds. Different alternatives investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are discussed comprehensively and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of bisphosphonates within coatings for improved fixation of orthopaedic implants are presented and critically evaluated. Finally, the authors\u2019 views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.","palabras_clave":"BISPHOSPHONATE|BONE TISSUE ENGINEERING|DRUG RELEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89782,"idioma_id":4,"titulo":"Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments","resumen":"This article provides an overview on the application of metallic ions in the fields of regenerative medicine and tissue engineering, focusing on their therapeutic applications and the need to design strategies for controlling the release of loaded ions from biomaterial scaffolds. A detailed summary of relevant metallic ions with potential use in tissue engineering approaches is presented. Remaining challenges in the field and directions for future research efforts with focus on the key variables needed to be taken into account when considering the controlled release of metallic ions in tissue engineering therapeutics are also highlighted.","palabras_clave":"METALLIC IONS|TISSUE ENGINEERING|SCAFFOLDS|BONE|DRUG DELIVERY|CONTROLLED RELEASE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89783,"idioma_id":4,"titulo":"Focus shift photothermal method for thermal diffusivity mapping","resumen":"AbstractIn this work, we present a photothermal technique that measures at microscopic spatial scales thecurvature of the surface of the sample due to the thermal expansion produced by a focusedmodulated laser beam. A modulated pump beam heats the sample surface and a probe beamdelivered through the same optical fiber and slightly defocused probes the curvature, by analyzingthe power collected by the same optical fiber. The collected power depends on the defocusingproduced by the curvature of the surface induced by the thermal expansion. The phase delay isdirectly related to the thermal diffusivity of the sample at the impinging location. The scheme isbased on the use of photonic technology borrowed from the optical communications field. In thisway, the setup results extremely robust, both lasers (pump and probe) are inherently collinear, asthey emerge from the same single mode fiber, and the detection is made through the same opticalfiber.","palabras_clave":"photothermal|thermal diffusivity|mapping|optical fiber."},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89784,"idioma_id":4,"titulo":"Vacuum-enhanced nickel induced crystallization of hydrogenated amorphous silicon","resumen":"Crystallization was performed by conventional furnace annealing at both atmospheric pressure and vacuum or low pressure conditions (&#8776; 10-6 Torr) for comparison. We have investigated the influence of low pressure during annealing on the resulting polycrystalline films by means of optical microscopy, ultraviolet reflectance and photoacoustic spectrometry measurements. A faster crystallization and a smaller grain size were observed when the process is carried out under vacuum, with an annealing time reduction of more than 50 %. We discuss, from a thermodynamical viewpoint, some possible causes by which vacuum annealing influences incubation and nucleation stages due to the presence of mobile hydrogen atoms inside the amorphous silicon matrix. Large grains with diameters of 30 and 100 &#956;m were obtained at vacuum and atmospheric pressure, respectively.","palabras_clave":"thin films|photoacoustic |crystallization |amorphous silicon"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89785,"idioma_id":5,"titulo":"Conjuntos líticos de la Quebrada de Mesada (Pcia. de Salta, Argentina). Análisis tecno- morfológico del material de superficie","resumen":"En este trabajo presentamos los resultados del análisis técnico morfológico de los artefactos líticos recuperados en superficie en la Quebrada de Mesada durante las campañas arqueológicas de 2005 y 2008. Si bien el conjunto analizado presenta características tendientes a la expeditividad, prácticas de mantenimiento y reciclaje, así como de uso de artefactos formatizados como forma base, junto con características espaciales y geográficas del área de estudio podrían ser indicativas de un uso recurrente de este espacio.","palabras_clave":"Artefactos Líticos|Conjuntos de Superficie|Puna de Salta"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89786,"idioma_id":4,"titulo":"Seasonal morphological variations and age-related changes of the seminal vesicle of viscacha (Lagostomus maximus maximus). An ultrastructural and immunohistochemical study.","resumen":"The viscacha is a seasonal rodent that exhibit an annual reproductive cycle with periods of maximum reproductive activity and gonadal regression. We studied seasonal variations in the morphology and cellular population of the seminal vesicles (SVs) during both periods and in impuber animals. Seminal vesicles were studied by light and electronic microscopy. Measurements of epithelial height, nuclear diameter, luminal diameter, and muscular layer were performed. Also,we studied the distribution of androgen receptors (AR) in this gland during the reproductive cycle and in impuber animal. During gonadal regression, principal and clear cells showed signs of reduced functional activity. These were characterized by an epithelium of smaller height, irregular nuclei, and cytoplasm with few organelles, dilated cisterns, and glycogen granules. In impuber animals, the principal cells showed large nuclei with chromatin lax and cytoplasm with small mitochondria, poorly developed Golgi apparatus, and granules of glycogen. On the other hand, the cells exhibited seasonal variations in the distribution and percentage of immunolabeled cells to ARthroughout the annual reproductive cycle. During the gonadal regression period, glandular mucosa exhibited numerous epithelial cells with intense nuclear staining. However, fibromuscular stromal cells were weakly positive for AR in contrast to what was observed during the activity period. Considering that testosterone values are lower in adult animals during the period of gonadal regression and in impuber animals, our immunohistochemical results show a significant correlationwith the percentage of AR-immunopositive cells. In conclusion, these results demonstrate that the structure of the SVs changes in the activity period of viscacha, probably because of elevated levels of testosterone leading to an increase in the secretory activity of epithelial cells.","palabras_clave":"SEMINAL VESICLES|SEASONAL REPRODUCTION|TESTOSTERONE LEVELS|IMPUBER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89787,"idioma_id":4,"titulo":"Autoinhibition mechanism of the plasma membrane calcium pump isoforms 2 and 4 studied through lipid-protein interaction , Adamo, H.P., Rossi, J.P.","resumen":"The autoinhibition\/activation of the PMCA (plasma membraneCa2+ -ATPase) involves conformational changes in the membraneregion of the protein that affect the amount of lipids directlyassociated with the transmembrane domain. The lipid\u2013proteindependenceof PMCA isoforms 2 and 4 expressed and obtainedin purified form from Saccharomyces cerevisiae was investigatedusing the phosphatidylcholine analogue [125I]TID-PC\/16{l-O-hexadecanoyl-2-O-[9-[[[2-[125I]iodo-4-(trifluoromemyl-3Hdiazirin-3-yl)benzyl]oxy]carbonyl]nonanoyl]-sn-glycero-3-phosphocholine},which was incorporated into mixtures ofdimyristoylphosphatidylcholine and the non-ionic detergentC12E10 [deca(ethylene glycol) dodecyl ether]. We found nodifferences between the recombinant PMCA4 and PMCApurified from erythrocytes (ePMCA). However, titration of thehalf-maximal activation by Ca2+ \/calmodulin of PMCA2 showed30-fold higher affinity than PMCA4. PMCA2 exhibited a lowerlevel of labelling in the autoinhibited conformation relative toPMCA4, indicating that the lower autoinhibition was correlatedwith a lower exposure to lipids in the autoinhibited state. Analysisof the lipid\u2013protein stoichiometry showed that the lipid annulus ofPMCA varies: (i) in accordance to the conformational stateof the enzyme; and (ii) depending on the different isoforms ofPMCA. PMCA2 during Ca2+ transport changes its conformationto a lesser extent than PMCA4, an isoform more sensitive tomodulation by calmodulin and acidic phospholipids. This is thefirst demonstration of a dynamic behaviour of annular lipids andPMCA.Key words: autoinhibition, calmodulin, lipid\u2013protein interaction,phospholipid, plasma membrane calcium-ATPase (PMCA).","palabras_clave":"plasma membrane calcium-ATPase (PMCA)|lipidprotein interaction|autoinhibition|calmodulin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89788,"idioma_id":5,"titulo":"Comparación de Desempeño de Controladores Fuzzy y Controladores Proporcionales","resumen":"El objetivo de este trabajo es comparar el desempeño de dos controladores fuzzy y un controlador proporcional. La variable controlada es el nivel de un tanque con descarga gravitatoria. Para realizar el estudio, se desarrolló un simulador dinámico implementado en Simulink® de MatLab®. Para cada controlador estudiado, se evaluó la respuesta producida ante un cambio escalón en el set point. Para realizar una comparación válida, los controladores fueron ajustados para producir offset iguales. Los resultados obtenidos muestran que los sistemas basados en heurísticas (controladores fuzzy) pueden ser tanto o más convenientes que aquellos basados en conocimiento determinístico (el controlador proporcional). Si bien el controlador proporcional actúa con mayor velocidad, los controladores fuzzy mejoran los valores de algunos de los índices más importantes de desempeño, como ser los sobrepicos, las oscilaciones y el factor de ripple.","palabras_clave":"CONTROLADORES FUZZY|MODELO MAMDANI|CONTROLADOR PROPORCIONAL|SIMULACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89789,"idioma_id":5,"titulo":"Análisis de sensibilidad por simulación del proceso de deshidratación de una planta de acondicionamiento de gas natural","resumen":"Este trabajo describe el desarrollo de un simulador estacionario para los sectores de deshidratación y estabilización de una planta de tratamiento de gas natural. El simulador fue implementado empleando el simulador comercial ASPEN HYSYS®. El gas considerado en la simulación es un gas típico proveniente de yacimientos de la provincia de Salta (Argentina). La configuración de la planta y las condiciones de operación adoptadas para la simulación son las generalmente empleadas en el tratamiento de gas natural en Salta. Con el simulador desarrollado, se llevó a cabo un estudio de sensibilidad paramétrica de las principales variables operativas del proceso. Este estudio permitió identificar a las variables críticas del proceso.","palabras_clave":"DESHIDRATACIÓN|ESTABILIZACIÓN|GAS NATURAL|SIMULACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89790,"idioma_id":5,"titulo":"Simulación estacionaria de un evaporador doble efecto para jugo de tomate","resumen":"    En este trabajo se desarrolló un modelo estacionario para simular un sistema evaporador de doble efecto destinado a la concentración de jugo de tomate. Debido a que el licopeno muestra capacidad antioxidante, es deseable que su concentración sea máxima en la pasta de tomate. Ello se logra optimizando tanto el diseño como las condiciones de operación del equipo concentrador de jugo. Para alcanzar ese objetivo, se incorporó en el modelo la cinética de degradación del licopeno, y se realizó un estudio de sensibilidad para determinar las relaciones que vinculan las variables de proceso. El estudio determinó que el contenido de licopeno en el producto es altamente sensible al tiempo de residencia; mientras que el consumo de vapor está determinado por la presión del vapor de servicio y las presiones de los efectos.                       ","palabras_clave":"TOMATE|LICOPENO|SIMULACIÓN|OPTIMIZACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89791,"idioma_id":5,"titulo":"Endulzamiento de gas natural con aminas. Simulación del proceso y análisis de sensibilidad paramétrico","resumen":"El gas natural es un recurso no renovable que debido a sus características combustibles se le ha dado una amplia gama de aplicaciones tales como uso doméstico, materia prima para la generación de energía eléctrica, combustible automotor y otros usos industriales. Este combustible posee componentes no deseados, y para ser utilizado debe cumplir con las especificaciones de la legislación vigente (ENARGAS). Por ello, debe ser sometido a diferentes tratamientos previos; uno de los más importantes es el procesos de endulzamiento, el cual consiste en disminuir la concentración de algunos compuestos indeseables como el ácido sulfhídrico y el dióxido de carbono, los que ocasionan contaminación, corrosión y restan poder calorífico al gas. En este trabajo se describe la simulación estacionaria de un proceso de endulzamiento con aminas.&nbsp; Compañías como Panamerican y Tecpetrol operan este tipo de plantas en la región noroeste de Argentina. El objetivo de este trabajo es realizar un análisis de sensibilidad. Los resultados de este análisis permiten identificar a las variables claves del proceso, las cuales serán consideradas en un posterior estudio de optimización. Para realizar el análisis de sensibilidad se empleó el simulador HYSYS® V7.1.","palabras_clave":"ENDULZAMIENTO|GAS NATURAL|AMINAS|SIMULACIÓN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89792,"idioma_id":5,"titulo":"El consumo elevado de licopeno sumado a una ingestión reducida de carnes rojas aumenta el poder antioxidante total","resumen":"Los sistemas antioxidantes del cuerpo humano son capaces de remover a los radicales libres, protegiendo así al organismo del daño que estos pueden ocasionar, y pueden ser valorados en conjunto mediante la determinación del poder antioxidante total (TAS, por sus siglas en inglés). Este biomarcador es modulado por la alimentación mediante la incorporación de sustancias con propiedades antioxidantes o prooxidantes. El objetivo del presente trabajo fue estimar la ingestión de nutrientes antioxidantes y grupos específicos de alimentos y correlacionarla con el TAS. Fueron seleccionados al azar 45 sujetos de sexo masculino, entre 50 y 75 años, de una consulta médica de rutina. El trabajo consistió en una evaluación de TAS mediante técnica ABTS más una entrevista nutricional donde se evaluó la composición corporal mediante antropometría y la ingestión &nbsp;habitual de nutrientes y grupos específicos de alimentos mediante un recordatorio de 24 h y un cuestionario de frecuencia de consumo de alimentos validado para tal fin. El análisis estadístico se realizó mediante Coeficiente de Correlación de Pearson o Spearman según la normalidad de la muestra (p&lt;0,05). El TAS se correlacionó positivamente con el consumo de licopeno (r=0,333; p=0,027) y negativamente con la ingestión de carnes rojas (r= -0,403; p=0,007). Los demás nutrientes o alimentos no se correlacionaron con el TAS. Por lo tanto, una ingestión elevada de licopeno y un consumo reducido de carnes rojas ayudarían a mejorar el sistema antioxidante del organismo","palabras_clave":"PODER ANTIOXIDANTE TOTAL|LICOPENO|CARNES ROJAS|ANTIOXIDANTES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89793,"idioma_id":4,"titulo":"Q-statistics in dynamic speckle pattern analysis","resumen":"We introduce q statistics concepts to improve the performance of some methods based on the histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.q statistics concepts to improve the performance of some methods based on the histogram to estimate dynamic speckle activity. It is shown that some improvements are obtained bychoosing appropriate q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.q values that have been empirically determined. The possibility of increasing the precision and diminishing the acquisition time are explored for a usual study case as is the dryingof paint.","palabras_clave":"Tsallis statistic|Dynamic speckle"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89794,"idioma_id":4,"titulo":"The Method of Convergence to calculate particles fluxes in X rays spectrometry techniques. Application in nuclear compounds","resumen":"A method to calculate particle fluxes applicable in most of the spectroscopy techniques is described. Flux intensities of backscattered or absorbed electrons and emitted photons are calculated using a Method of Convergence to solve the Invariant Embedding equations that are used to describe the particle trajectories inside a solid sample. Our results are found to be helpful to carry out a procedure for quantitative characterization using instruments such as Electron Probe Microanalyser or other probes. Examples of application to calculate the composition of ternary alloys are given and are compared with the same calculations using another procedure.","palabras_clave":"CONVERGENCE|X-RAY SPECTROSCOPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89795,"idioma_id":4,"titulo":"Collision entropy and optimal uncertainty","resumen":"We propose an alternative measure of quantum uncertainty for pairs of arbitrary observables in the 2-dimensional case, in terms of collision entropies. We derive the optimal lower bound for this entropic uncertainty relation, which results in an analytic function of the overlap of the corresponding eigenbases. Besides, we obtain the minimum uncertainty states. We compare our relation with other formulations of the uncertainty principle.","palabras_clave":"UNCERTAINTY RELATIONS|COLLISION ENTROPY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89796,"idioma_id":5,"titulo":"Arqueometría del arte: estudios fisicoquímicos de pigmentos arqueológicos","resumen":"En este trabajo presentamos un panorama actualizado sobre los estudios de arqueometría de pigmentos arqueológicos desarrollados en la República Argentina. Para ello hemos revisado y cuantificado bibliométricamente trabajos presentados en los congresos y reuniones nacionales e internacionales sobre Arqueometría y llevados a cabo en el sur de Sudamérica.De acuerdo con la variedad de trabajos presentados en el Dossier de esta publicación revisamos y comentamos, asimismo, las principales técnicas de análisis aplicadas al estudio de pigmentos, así como los resultados y conclusiones a los cuales han llegado los colegas que colaboran con este dossier. Por último, evaluamos los alcances y limitaciones de dichos trabajos destacando los frutos del trabajo interdisciplinario.","palabras_clave":"ARQUEOMETRIA|TÉCNICAS|PIGMENTOS|CONTEXTOS ARGENTINOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89797,"idioma_id":4,"titulo":"Forest fragmentation leads to food web contraction","resumen":"Fragmentation and loss of habitat are critical components of the global change currently threatening biodiversity and ecosystem functioning. We studied the effects of habitat loss through fragmentation on food web structure, by constructing and analyzing plant-herbivore and host-parasitoid food webs including more than 400 species and over 120 000 feedingrecords, in 19 Chaco Serrano remnants of differing areas. Food web structure was altered by habitat fragmentation, with different metrics being affected depending on interaction type, and with all changes being driven by the reduced size of networks in smaller fragments. Only connectance varied in both quantitative and qualitative analyses, being negativelyrelated to area. In addition, the interactions were represented by proper successive subsets, modulated mainly by resource availability (plant?herbivore) or consumer specialization (host?parasitoid), as forest size decreased. The results suggest that habitat loss has led to food web contraction around a central core of highly-connected species, for plant?herbivore as well as for host?parasitoid systems. The study provides new insights into the effects of human perturbations on complex biological systems.","palabras_clave":"habitat fragmentation|ecological networks|host-parasitoid|plant-herbivore"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89798,"idioma_id":4,"titulo":"Forest fragmentation reduces parasitism via species loss at multiple trophic levels","resumen":"&nbsp;Although there is accumulating evidence from arti&#64257;cially assembled commu-nities that reductions of species diversity result in diminished ecosystem functioning, it is not yet clear how real-world changes in diversity affect the &#64258;ow of energy between trophic levels in multi-trophic contexts. In central Argentina, forest fragmentation has led to species loss of plants,&nbsp; herbivore&nbsp; and&nbsp; parasitoid&nbsp; insects,&nbsp; decline&nbsp; in&nbsp; trophic&nbsp; processes&nbsp; (herbivory&nbsp; and parasitism), and food web contraction. Here we examine if and how loss of parasitoid species following fragmentation causes decreased parasitism rates, by analyzing food webs of leaf miners and parasitoids from 19 forest fragments of decreasing size. We asked three questions: Do&nbsp; reductions&nbsp; in&nbsp; parasitoid&nbsp; richness&nbsp; following&nbsp; fragmentation&nbsp; directly&nbsp; or&nbsp; indirectly&nbsp; affect parasitism rate? Are changes in community parasitism rate driven by changes in the parasitism rate of individual leaf miner species, or changes in leaf miner composition, or both? Which traits of species determine the effects of food web change on parasitism rates? We found that habitat&nbsp; loss&nbsp; initiated&nbsp; a&nbsp; bottom-up&nbsp; cascade&nbsp; of&nbsp; extinctions&nbsp; from&nbsp; plants&nbsp; to&nbsp; leaf&nbsp; miners&nbsp; to parasitoids, with reductions in parasitoid richness ultimately driving decreases in parasitism rates. This relationship between parasitoid richness and parasitism depended on changes in the relative abundance (but not occurrence) of leaf miners such that parasitoid-rich fragments were dominated by leaf miner species that supported high rates of parasitism. Surprisingly, we found that only a small subset of species in the food web could account for much of the increase in parasitism with parasitoid richness: lepidopteran miners that attained exceptionally high densities in some fragments and their largely specialist parasitoids. How specialized a parasitoid is, and the relative abundance of leaf miners, had important effects on the diversity?parasitism rate relationship, but not other leaf miner traits including trophic breadth, body size,&nbsp; and&nbsp; mine&nbsp; shape.&nbsp; Our&nbsp; results&nbsp; show&nbsp; that&nbsp; a&nbsp; full&nbsp; understanding&nbsp; of&nbsp; the&nbsp; functional consequences&nbsp; of&nbsp; perturbations&nbsp; and&nbsp; species&nbsp; loss&nbsp; requires&nbsp; both&nbsp; a&nbsp; multi-trophic&nbsp; perspective and a trait-based approach, which together capture some of the biological complexity of natural systems.","palabras_clave":"biodiversity|ecosystem functioning|habitat loss| leaf miners"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89799,"idioma_id":4,"titulo":"Defects in the vasoactive intestinal peptide (VIP)\/VPAC system during early stages of the placental-maternal leucocyte interaction impair the maternal tolerogenic response","resumen":"Successful embryo implantation occurs followed by a local inflammatory\/T helper type 1 (Th1) response, subsequently redirected towards a tolerogenic predominant profile. The lack of control of this initial local inflammatory response may be an underlying cause of early pregnancy complications as recurrent spontaneous abortions (RSA). Considering that vasoactive intestinal peptide (VIP) mediates anti-inflammatory and tolerogenic effects in several conditions we hypothesized that VIP might contribute to tolerance towards trophoblast antigens during the early interaction of maternal leucocytes and trophoblast cells. In this study we investigated VIP\/VPAC system activity and expression on maternal peripheral blood mononuclear cells (PBMCs) after interaction with immortalized trophoblast cells (Swan-71 cell line) as an in-vitro model of feto-maternal interaction, and we analysed whether it modulates maternal regulatory T cell (T(reg))\/Th1 responses. We also investigated the contribution of the endogenous VIP\/VPAC system to RSA pathogenesis. VIP decreased T-bet expression significantly, reduced monocyte chemotactic protein-1 (MCP-1) and nitrite production in co-cultures of PBMCs from fertile women with trophoblast cells; while it increased the frequency of CD4(+) CD25(+) forkhead box protein 3 (Foxp3)(+) cells, transforming growth factor (TGF)-&#946; expression and interleukin (IL)-10 secretion. These effects were prevented by VIP-specific antagonist. Interestingly, PBMCs from RSA patients displayed significantly higher T-bet expression, lower T(reg) frequency and lower frequency of VIP-producer CD4 lymphocytes after the interaction with trophoblast cells. Moreover, the patients displayed a significantly lower frequency of endometrial CD4(+) VIP(+) cells in comparison with fertile women. VIP showed a Th1-limiting and T(reg) -promoting response in vitro that would favour early pregnancy outcome. Because RSA patients displayed defects in the VIP\/VPAC system, this neuropeptide could be a promising candidate for diagnostic biomarker or surrogate biomarker for recurrent spontaneous abortions.","palabras_clave":"VIP|MATERNAL TOLERANCE|RECURRENTE SPONTANEOUS ABORTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89800,"idioma_id":4,"titulo":"Quercetin 3, 7, 3, 4´-tetrasulphated isolated from Flaveria bidentis inhibits tissue factor expression in human monocyte","resumen":"Sulphated esters of the flavonoids sulphated quercetin 3,7,3,4-tetrasulphated (QTS) and quercetin 3-acetyl-7,3,4-trisulphate (ATS), isolated from Flaveria bidentis, have demonstrated anticoagulant andantiplatelet properties. In this study, we examined if both compounds affected the expression of theprocoagulant tissue factor (TF) induced by lipopolysaccharide (LPS) on human monocyte. Monocyteswere pretreated with different concentrations of each flavonoid (0.1\u2013500 M), followed by a 4 h incubationwith LPS in order to induce TF expression. Results of the TF expression showed different behaviorsfor the two flavonoids studied. A slight inhibitory effect on the TF expression was detected at a QTS concentrationof 0.1 M, but from 1 M onwards a significant inhibitory effect that remained up to 500 Mcould be observed. In contrast, ATS induced a poor inhibitory effect on TF expression at all concentrationstested. These results suggest that QTS has another antithrombotic property, to be added to its alreadyrenowned ability as an anticoagulant and antiplatelet compound.","palabras_clave":"quercetin|monocytes|Flaveria bidentis"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89801,"idioma_id":4,"titulo":"Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from Larrea divaricata Cav (Zygophyllaceae)","resumen":"SUMMARY. The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used infolk medicine against infectious diseases. In previous studies, we reported that several extracts obtainedfrom the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibitedJunin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsiblefor the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extractswere determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibitJUNV and observed that some components of the bioactive extracts would increase the antiviral effect ofNDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA andextracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the ArgentineHemorrhagic Fever, an endemo-epidemic illness in this country.","palabras_clave":"NORDIHYDROGUIARETIC ACID|ANTIVIRAL|LARREA DIVARICATA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89802,"idioma_id":4,"titulo":"?\tDetermination of non-toxic and subtoxic concentrations of potential antiviral natural anthraquinones","resumen":"SUMMARY. Anthraquinones-rich extracts of Heterophyllaea pustulata Hook f. (Rubiaceae) exhibited in vitro antiviral activity against Herpes Simplex Virus Type I, from which several anthraquinones (AQs) were isolated and identified. The Maximum Non-Cytotoxic Concentration (MNCC), the subtoxic concentration (SubTC), and the CC50 of each AQ were determined on a mammalian eukaryotic cell line (Vero cells) by means of Neutral Red uptake assay; the cytopathic effect was simultaneously evaluated by optical microscopy. The range of concentrations where each AQ did not exhibit cytotoxicity was established, which is limited by the MNCC: rubiadin 1-methyl ether, damnacanthol and pustuline were found to be markedly less cytotoxic. To the remaining AQs, we could estimate a SubTC (about 10 ìg\/mL) that assures 80 % cellular viability. Therefore, we determined a concentration range which could be used to evaluate the antiviral effect of each AQ since it ensures the viability of the host cell","palabras_clave":"ANTHRAQUINONES|CYTOTOXICITY|HETEROPHYLLAEA PUSTULATA|SUPEROXIDE ANION|VERO CELLS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89803,"idioma_id":4,"titulo":"Apoptosis and mutagenicity induction by a characterized aqueous extract of Baccharis articulata (Lam.) Pers. (Asteraceae) on normal cells","resumen":"In a previous study we have demonstrated that cold aqueous extract of Baccharis articulata (Ba-CAE) induced the death of human peripheral blood mononuclear cells (PBMCs) and exerted low mutagenic effects on mice at 6 h after  administration. The aim of this work was to investigate whether the PBMCsdeath induced by Ba-CAE is due to apoptosis, and whether this extract exerts mutagenic effects on mice at 24 and 48 h after administration. In addition, Ba-CAE was chemically characterized. PBMCs from healthy volunteers were exposed to extract (10, 20, 40, 80, 160, 320, 640 and 1280 lg\/mL) for 18?24 h. Cell viability was determined by staining of trypan blue dye exclusion method. Apoptosis was determined by Hoechst 33258 staining, TUNEL, and DNA fragmentation analysis by agarose gel electrophoresis. BALB\/c mice were injected with extract (1800, 900 and 450 mg\/kg) and sacrificed at 24 and 48 h postinjection. Bone marrow samples were used to assess chromosome mutations by the micronucleus test. The extract induced PBMCs death by apoptosis and increased the frequency of micronuclei in bone marrow. The phytochemical study of Ba-CAE showed the presence of flavones as luteolin and acacetin, caffeoylquinic acids as chlorogenic acid, and tannins.","palabras_clave":"BACCHARIS ARTICULATA|MUTAGENIC|AQUEOUS EXTRACT|APOPTOSIS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89804,"idioma_id":4,"titulo":"Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C)","resumen":"Some studies have shown that probiotics, including Lactobacillus rhamnosus CRL1505 (Lr1505), had the potential to beneficially modulate the outcome of certain bacterial and viral respiratory infections. However, these studies did not determine the mechanism(s) by which probiotics contribute to host defense against respiratory viruses. Results: In this work we demonstrated that orally administered Lactobacillus rhamnosus CRL1505 (Lr1505) was able to increase the levels of IFN-&#947;, IL-10 and IL-6 in the respiratory tract and the number of lung CD3+CD4+IFN-&#947;+ T cells. To mimic the pro-inflammatory and physiopathological consecuences of RNA viral infections in the lung, we used an experimental model of lung inflammation based on the administration of the artificial viral pathogen-associated molecular pattern poly(I:C). Nasal administration of poly(I:C) to mice induced a marked impairment of lung function that was accompanied by the production of pro-inflammatory mediators and inflammatory cell recruitment into the airways. The preventive administration of Lr1505 reduced lung injuries and the production of TNF-&#945;, IL-6, IL-8 and MCP-1 in the respiratory tract after the challenge with poly(I:C). Moreover, Lr1505 induced a significant increase in lung and serum IL-10. We also observed that Lr1505 was able to increase respiratory IFN-&#947; levels and the number of lung CD3+CD4+IFN-&#947;+ T cells after poly(I:C) challenge. Moreover, higher numbers of both CD103+ and CD11bhigh dendritic cells and increased expression of MHC-II, IL-12 and IFN-&#947; in these cell populations were found in lungs of Lr1505-treated mice. Therefore, Lr1505 treatment would beneficially regulate the balance between pro-inflammatory mediators and IL-10, allowing an effective inflammatory response against infection and avoiding tissue damage. Conclusions: Results showed that Lr1505 would induce a mobilization of cells from intestine and changes in cytokine profile that would be able to beneficially modulate the respiratory mucosal immunity. Although deeper studies are needed using challenges with respiratory viruses, the results in this study suggest that Lr1505, a potent inducer of antiviral cytokines, may be useful as a prophylactic agent to control respiratory virus infection.","palabras_clave":"L. rhamnosus CRL1505|POLI(I:C)|ANTIVIRAL IMMUNITY|RESPIRATORY TRACT"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89805,"idioma_id":4,"titulo":"CYTOTAXONOMY OF TRIPOGANDRA DIURETICA AND T. GLANDULOSA (COMMELINACEAE) FROM NE ARGENTINA","resumen":"Abstract Karyotype features and microsporogenesis of Tripogandra diuretica (Mart.) Handlos and Tripogandra glandulosa (Seub.) Rohw. from 15 NE Argentina accessions are analysed via classical cytogenetics, CMA\/DA\/DAPI and Ag-NOR. The karyotype of T. glandulosa (2n = 2x = 16; 2m + 6sm + 8st) is bimodal (A 2 = 0.37; R = 2.65) and asymmetrical (A 1 = 0.63; i = 26.06; r &gt; 2 = 0.88) (3B-Stebbins) with a genome size of 33.28 ìm; two pairs are satellited, CMA+ and NOR-actives. Another four CMA+ loci and DAPI+ universal centromeric heterochromatin occur. Microsporogenesis is normal (pollen viability short stamens = 97.8%; large = 96.7%), meiotic behaviour is regular and chromosomes pair as 8II. The karyotype of T. diuretica (2n = 8x = 64; 8m + 24sm + 32st) is bimodal (A 2 = 0.27; R = 2.54) and asymmetrical (A 1 = 0.60; i = 27.32;r &gt; 2 = 0.88) (3B-Stebbins); additionally, two pairs are satellited. Microsporogenesis is normal (short stamens = 77.8%; large = 68.5%), except for micronuclei and low pollen viability in some accessions. Meiotic behaviour is regular with 32II, acting as a cytological diploid, however the arrangement of the haploid karyotype suggests that T. diuretica, which also exhibits a reduction of the genome size (18.58 ìm), constitutes an auto-octoploid taxa. Additionally, both species share cytological features common to karyotype orthoselection.","palabras_clave":"Chromosomes|cytogenetics|evolution|taxonomy|Tripogandra"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89806,"idioma_id":4,"titulo":"Asteraceae","resumen":"Resumen   Chromosome numbers and karyotype morphology are described for three taxa of Heliantheae Cass. (Asteraceae) from NE Argentina for the first time. Angelphytum hatschbachii H. Rob. (27º17´S, 55º34´W) has 2n = 64 chromosomes and this is the first chromosome count for this species restricted to Misiones Province. Aspilia montevidensis (Spreng.) Kuntze var. montevidensis (27º34´S, 55º34´W) showed 2n = 44 chromosomes. This species naturally grows in northeast regions of Argentina (restricted to Chaco, Corrientes, Entre Ríos, Formosa, Santa Fe and Misiones Provinces), Brazil, Paraguay and Uruguay. Two varieties have been described for this taxon, var. montevidensis and var. setosa (Griseb.) Cabrera.  Aspilia montevidensis var. montevidensis is tetraploid with 2n = 4x = 44 chromosomes. Previous chromosome counts in A. montevidensis var. setosa have shown the existence of a polyploid complex composed by diploids (2n = 2x = 22), tetraploids (2n = 4x = 46) and hexaploids (2n = 6x = 68) with a base number of x = 11. Cytotypes of this complex are differentially distributed in eastern Argentina (2x), southern Brazil (4x) and southern Paraguay (6x). In agreement with previous reports, our tetraploid cytotype has x = 11, nevertheless at tetraploid level both varieties can be distinguished by morphological features and an additional pair of chromosomes. Calea uniflora Less. (27º17´S, 55º34´W) presented 2n = 32 chromosomes. This taxon occurs in northeast Argentina (restricted to Corrientes, Entre Ríos and Misiones Provinces), Brazil, Paraguay and Uruguay. Calea uniflora is diploid and possess a karyotype formula of 24 m + 8 sm. The smallest chromosome has 2.51 &#956;m (m) and the largest 4.37 &#956;m (m) with a mean chromosome length of 3.17 &#956;m. The karyotype is unimodal (A2 = 0.16; R = 1.73) and symmetrical (A1 = 0.28; r > 2 = 0.18; i = 41.15; AI = 1.99) (Stebbins´ category 2A of karyotype asymmetry). The haploid genome has 50.76 &#956;m. Our record is added to a previous contribution in which n = 16 II was observed in populations from Paraguay.","palabras_clave":"CHROMOSOME NUMBER|KARYOTYPE|NE ARGENTINA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89807,"idioma_id":4,"titulo":"Phytoestrogens Enhance the Vascular Actions of the Endocannabinoid Anandamide in Mesenteric Beds of Female Rats","resumen":"Phytoestrogens Enhance the Vascular Actions of the ....","palabras_clave":"ANANDAMIDE|PHYTOESTROGENS|CARDIOVASCULAR|SEX DIFFERENCES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89808,"idioma_id":4,"titulo":"Graph based cellular automata for simulation of surface flows in large plains.","resumen":"A cellular automata supported by a graph structure was developed for simulating surface flows in planes. Differing from the classical regular grids used by most cellular automata the present model is supported by a graph structure, which provides higher flexibility to represent complex geographic domains with different scales. The model calculates the water transfer between adjacent cells based on a hydraulic equation assigned to the arcs of the graph. The model includes infiltration and evaporation sources in each cell. Comparisons against hydrau-lic measurement performed during flooding events show excellent agreement.","palabras_clave":"Cellular Automata|Graphs|Simulation|Fluids|Surface flow"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89809,"idioma_id":4,"titulo":"A Lattice-Boltzmann solver for 3D fluid simulation on GPU","resumen":"A three-dimensional Lattice-Boltzmann fluid model with nineteen discrete velocities was implemented using NVIDIA Graphic Processing Unit (GPU) programing language ?Compute Unified Device Architecture? (CUDA). Previous LBM GPU implementations required two steps to maximize memory bandwidth due to memory access restrictions of earlier versions of CUDA toolkit and hardware capabilities. In this work, a new approach based on single-step algorithm with a reversed collision?propagation scheme is developed to maximize GPU memory bandwidth, taking advantage of the newer versions of CUDA programming model and newer NVIDIA Graphic Cards. The code was tested on the numerical calculation of lid driven cubic cavity flow at Reynolds number 100 and 1000 showing great precision and stability. Simulations running on low cost GPU cards can calculate 400 cell updates per second with more than 65% hardware bandwidth","palabras_clave":"GPGPU|3D Lattice-Boltzmann Methods|CUDA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89810,"idioma_id":4,"titulo":"Utilization of special potential scan programs for cyclic voltammetric development of different nickel oxide-hydroxide species on Ni based electrodes","resumen":"Special potential scan programs were designed for cyclic voltammetric development of &#946;-NiOOH or &#947;-NiOOH\/ &#946;-NiOOH mixtures on the surface of nickel or nickel-chromium (80:20) alloy electrodes in NaOH 0.10 M. The pro- grams consisted on changing the anodic or cathodic switching limit to facilitate the chemical reactions taking place ei- ther between Ni(II) hydroxides or between Ni(III) oxides-hydroxides. The electrochemical charge density under the oxidative wave, observed at Ni or Ni-Cr electrode surfaces at approximately 0.48 V (vs SCE), remained almost con- stant with the number of cv cycles after approximately 600 cv cycles at 0.050 V\/s. Thus, it can be suggested that a stable proportion of Ni(II)\/Ni(III) oxides-hydroxides was obtained on the electrode surfaces. The relative amounts of &#946;-NiOOH or &#947;-NiOOH species were calculated from the electrochemical charges under their reduction waves in the voltammetric experiments. Higher charge densities were always obtained with Ni-Cr alloy electrodes as compared to pure Ni electrodes. Linear relationships were obtained in our study on the dependence of the oxidative peak current with the square root of the scan rate at a scan rate range between 0.01 V\/s and 0.16 V\/s.","palabras_clave":"Nickel|Nickel-Chromium Alloy|Oxides|Cyclic Voltammetry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89811,"idioma_id":4,"titulo":"Mineral chemistry and geothermometry using relict primary minerals in the La Cocha ultramafic body: a slice of the upper mantle in the Sierra Chica of Córdoba, Sierras Pampeanas, Argentina","resumen":"The La Cocha ultramafic body, in the Sierra Chica of Córdoba (Sierras Pampeanas, Argentina), is formed by serpentinized spinel harzburgites, with lenses of spinel pyroxenites and hornblendites. The associated metamorphic rocks are garnet sillimanite gneisses, intercalated with tabular bodies of pyroxene amphibolites and forsterite marbles.   Mineral chemistry of relict primary phases (olivine, orthopyroxene and spinel) from samples of the spinel harzburgites and pyroxenites was determined, and several geothermometers were applied to estimate the temperature conditions under which these rocks may have been equilibrated.  In the spinel harzburgites, the primary spinel is Al-chromite [Cr# = Cr\/(Cr + Al) = 0.48-0.57], which is replaced by ferrichromite and chlinoclore by metamorphism. Orthopyroxene is enstatite (En92) and olivine is classified as forsterite (Fo92); this last one shows a homogeneous and constant composition along the ultramafic body. Using geothermometric calibrations of the pair olivine?spinel, the highest temperature of 1157 ºC would correspond to the primary conditions of formation of the harzburgites.   The spinel pyroxenites show a mineral composition defined by orthopyroxene (En85, enstatite), olivine (Fo86, chrysolite), spinel (s. s.) and magnetite. Serpentine and clinochlore were produced by metamorphism. Spinel has high concentrations in Al and very low in Cr, and is classified as spinel sensu stricto; magnetite replacement was produced by metamorphism. Orthopyroxene and olivine are depleted in MgO regarding these minerals in the harzburgites. Temperatures of 785-734 ºC calculated using geothermometers with orthopyroxene are interpreted to be produced by metamorphism in amphibolite to granulite facies conditions.  Cumular textures were not observed in outcrops and thin sections of the studied rocks. The narrow composicional range and high forsterite content in olivine, the high Cr# in spinel, and the low concentrations of Ni and Cr in whole rock analyses indicate a mantle residual origin for these peridotites, which would exclude a cumular origin.  The association of peridotites with mafic bodies formed in an N?type MORB environment and a relict mantle fabric showed by the elongated crystals\/aggregates of olivine (preserved in pseudomorphic replacements), indicating a high temperature flow, allow to interpret the La Cocha ultramafic body as a slice of oceanic mantle, belonging to basal tectonites of an ophiolite complex. This body shows similar petrological, geochemical and structural features than the other ultramafic bodies in the Sierras de Córdoba, therefore the origin proposed here could be applied to the other bodies.","palabras_clave":"Ultramafic rocks|Mineral chemistry|Geothermometry|Upper mantle|Sierras Pampeanas|Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89812,"idioma_id":4,"titulo":"Saline and osmotic stress differentially affects apoplastic and intracellular reactive oxygen species production, curling and death of root hair during Glycine max L.- Bradyrhizobium japonicum interaction","resumen":"In the present study, the production of apoplastic and intracellular reactive oxygen species (ROS) and deformations of young soybean root hairs inoculated with Bradyrhizobium japonicum strain USDA138 were analyzed under saline and osmotic stress. Sustained and transient increase of apoplastic and intracellular ROS production, respectively, were observed in inoculated root hairs. The apical production of  apoplastic superoxide in growing root hairs colocalized with &#64258;avonoid auto&#64258;uorescence and both were relocated to the zone ofmaximumcurvature in curled root hairs. Saline and osmotic stress had differential effects on both the production of apoplastic ROS and curling: only saline stress inhibited both processes in a dose-dependent manner. Intracellular ROS production was not altered by osmotic stress but was inhibited completely by 150mM NaCl. In inoculated root hairs under 50mM NaCl, the intracellular ROS levels were initially increased, but not decreased at later stages, as occurred in control conditions. Root hair death was induced by 150mM NaCl in both inoculated and noninoculated roots and by 50mM NaCl only in inoculated roots. Saline, but not osmotic stress, marked affects both apoplastic and intracellular ROS production, inhibiting root hair curling and inducing root hair death.","palabras_clave":"Root hair deformation    |ROS production|Salinity|Root hair death|Rhizobium |Legume interaction"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89813,"idioma_id":4,"titulo":"Isolation of Yellow Fever Virus from Mosquitoes in Misiones Province Argentina","resumen":"  Yellow fever (YF) is a viral hemorrhagic fever endemic to tropical regions of South America and Africa. From  2007 to 2009 an important epidemic\/epizootic of YF was detected in different populations of howler monkeys  (Alouatta species) in Misiones, a northeastern Argentinian province. Yellow fever virus (YFV) infection was  researched and documented by laboratory tests in humans and in dead Alouatta caraya´. The objective of that  research was to investigate the circulation of YFV in mosquitoes, which could be implicated in the sylvatic  transmission of YF in Argentina. The above-mentioned mosquitoes were captured in the same geographical  region where the epizootic took place. A YFV strain was isolated in cell culture from pools of Sabethes albiprivus.  This study is not only the first isolation of YFV from mosquitoes in Argentina, but it is also the first YFV isolation  reported in the species Sabethes albiprivus, suggesting that this species might be playing a key role in sylvatic YF  in Argentina.","palabras_clave":"Arboviruses|Mosquitoes|Vector|Yellow Fever Virus"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89814,"idioma_id":4,"titulo":"Tara tannin a natural product with antifouling coating application","resumen":"The international trade by marine transportation has increased continuously since the 70s. The undesirableaccumulation of a wide variety of marine organisms (biofouling) on ship hulls can lead to significantincreased costs, principally by increased fuel consumption. On the other hand, there is a great concernabout the biocides commonly used in commercial antifouling (AF) protective systems due to the highconcentration encountered in coastal areas and the potential damage they could cause to marine organisms.As a consequence, the development of alternative AF coatings with new natural products as biocidesinhibit is a key factor. In this approach, tara tannin (TT) is being proposed as a promising solution. It isimportant to note that TT is obtained from the pods of the tree avoiding its cutting down. The aim ofthis research was, primarily, to explore the possible application of a natural and abundant product, suchas the TT, in the preparation of AF coatings. So, a TT derivative was obtained and characterized to beemployed as the bioactive compound in AF coatings. Previous to the immersion in natural environments,the dissolution of TT from AF coating in artificial sea water (ASW) was studied. TT was incorporated intothe coating as zinc \u201Ctannate\u201D. One of the tested coatings proved to be efficient in AF protection in naturalsea water (NSW) at Mar del Plata (38&#9702;0817S\u201357&#9702;3118W) harbor during eight months. The addition of2% by weight of zinc oxide to the coating extended its service life until the year.","palabras_clave":"BIOFOULING|COATINGS BIOCIDES|TARA TANNIN|LEACHING RATE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89815,"idioma_id":4,"titulo":"Quaternary ammonium 'tannate' for antifouling coatings","resumen":"The undesirable accumulation of a wide variety of marine organisms (biofouling) on ship hulls can lead to significant increased costs, principally by increased fuel consumption to maintain cruising speed. Generally, these coatings have bioactive compounds, called biocides.  In this sense, this paper deals with the assessment of the antifouling properties of a natural product derivative obtained from 'quebracho' tannin and a quaternary ammonium salt (hexadecyltrimethylammonium bromide ([CH3(CH2)15N(CH3)3]Br) . Two derivatives were obtained depending on the precipitation pH (4 and 8). The bioactivity of these derivatives was assessed by means of the Artemia larvae test.  Furthermore, soluble matrix paints were prepared with two different binders: rosin \/ oleic acid and rosin \/ styrene-acrylate copolymer. The leaching of 'quebracho' tannin derivatives from coatings in artificial sea water was monitored until obtain constant values, previous to the immersion in natural environments. Finally, the antifouling activity of coatings pigmented with the ?quebracho? tannin derivative was evaluated in Mar del Plata harbor (38º08´17´´S-57º31´18´´W). The coating obtained with the derivative obtained at pH4 and rosin \/ oleic acid as binder proved to have an acceptable efficiency for ten months.","palabras_clave":"Quaternary Ammonium|Antifouling Coating|Biofouling|Quebracho Tannin"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89816,"idioma_id":4,"titulo":"A multiwavelength study of the supernova remnant G296.8-0.3","resumen":"We report XMM-Newton observations of the  Galactic supernova remnant G296.8-0.3, together with complementary  radio and infrared data. The spatial and spectral  properties of the X-ray emission, detected towards  G296.8-0.3, was investigated in order to explore the possible  evolutionary scenarios and the physical connexion  with its unusual morphology detected at radio frequencies.  G296.8-0.3 displays diffuse X-ray emission correlated with  the peculiar radio morphology detected in the interior of the  remnant and with the shell-like radio structure observed to  the northwest side of the object. The X-ray emission peaks  in the soft\/medium energy range (0.5\u20133.0 keV). The X-ray  spectral analysis confirms that the column density is high  (NH &#8764; 0.64 × 1022 cm&#8722;2) which supports a distant location  (d > 9 kpc) for the SNR. Its X-ray spectrum can be  well represented by a thermal (PSHOCK) model, with kT &#8764;  0.86 keV, an ionization timescale of 6.1 × 1010 cm&#8722;3 s, and  low abundance (&#8764;0.12 Z). The 24 &#956;m observations show  shell-like emission correlated with part of the northwest and  southeast boundaries of the SNR. In addition a point-like  X-ray source is also detected close to the geometrical center  of the radio SNR. The object presents some characteristics  of the so-called compact central objects (CCO). Its X-ray  spectrum is consistent with those found at other CCOs and  the value of NH is consistent with that of G296.8-0.3, which  suggests a physical connexion with the SNR.","palabras_clave":"ISM: individual objects: G296.8-0.3|ISM: supernova remnants · X-ray|ISM · Radiation mechanism: thermal|ISM: individual objects: 2XMMi J115836.1-623516"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89817,"idioma_id":4,"titulo":"AE Aurigae: First Detection of Non-thermal X-Ray Emission from a Bow Shock Produced by a Runaway Star","resumen":"Runaway stars produce shocks when passing through interstellar medium atsupersonic velocities. Bow shocks have been detected in the mid-infraredfor several high-mass runaway stars and in radio waves for one star.Theoretical models predict the production of high-energy photons bynon-thermal radiative processes in a number sufficiently large to bedetected in X-rays. To date, no stellar bow shock has been detected atsuch energies. We present the first detection of X-ray emission from abow shock produced by a runaway star. The star is AE Aur, which waslikely expelled from its birthplace due to the encounter of two massivebinary systems and now is passing through the dense nebula IC 405. TheX-ray emission from the bow shock is detected at 30'' northeast of thestar, coinciding with an enhancement in the density of the nebula. Fromthe analysis of the observed X-ray spectrum of the source and ourtheoretical emission model, we confirm that the X-ray emission isproduced mainly by inverse Compton upscattering of infrared photons fromdust in the shock front.","palabras_clave":"mechanism: non-thermal|stars: individual AE Aur.|stars: kinematics|X-ray: general"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89818,"idioma_id":5,"titulo":"Desarrollo de competencias a través de los videojuegos deportivos: alfabetización e identidad","resumen":"En este trabajo analizamos el papel de los videojuegos deportivos como instrumento de aprendizaje. Nos centramos en su potencial para el desarrollo de habilidades cognitivas por parte de los adolescentes en conexión con dos conceptos: la formación de identidades y el manejo de las normas. Deporte y juego desempeñan un papel destacado en la vida de los adolescentes, ya que el interés por ambas actividades ocupa un espacio importante en su tiempo de ocio. En este sentido, los videojuegos deportivos pueden ser un excelente mediador, puesto que facilitan la combinación de distintas facetas de los juegos y del deporte, como el entretenimiento, el desarrollo físico, el estímulo psicológico y la competencia (Wolf, 2003).  Nuestro trabajo está basado en una investigación realizada desde la etnografía (Pink, 2006), programando una actividad en el aula con un docente en el ámbito de la Educación Física.   En este escenario, hemos utilizado videojuegos relacionados con deportes de equipo para conectar entornos reales y virtuales en el espacio del aula, contribuyendo así al desarrollo de habilidades cognitivas que permiten a los adolescentes reflexionar activamente sobre las relaciones entre el contenido del videojuego y los contextos de actividad reales (Gee, 2008).","palabras_clave":"IDENTIDADES|NORMAS|HABILIDADES COGNITIVAS|REPRESENTACIÓN|SIMULACIÓN|DEPORTE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89819,"idioma_id":4,"titulo":"On the origin of the jet-like radio\/X-ray morphology of G290.1-0.8","resumen":"Context. The origin and evolution of supernova remnants of the mixed-morphology class is not well understood. Several remnants  present distorted radio or X-ray shells with jet-like structures. G290.1&#8722;0.8 (MSH 11-61A) belongs to this particular class.  Aims. We aim to investigate the nature of this supernova remnant in order to unveil the origin of its particular morphology. We based  our work on the study of the X-ray emitting plasma properties and the conditions imposed by the cold interstellar medium where the  remnant expanded.  Methods. We use archival radio, Hi line data and X-ray observations from XMM-Newton and Chandra observatories, to study  G290.1&#8722;0.8 and its surrounding medium in detail. Spatially resolved spectral analysis and mean photon energy maps are used to  obtain physical and geometrical parameters of the source. Radio continuum and Hi line maps give crucial information to understand  the radio\/X-ray morphology.  Results. The X-ray images show that the supernova remnant presents two opposite symmetric bright spots on a symmetry axis running  towards the north west-south east direction. Spectral analysis and mean photon energy maps confirm that the physical conditions of  the emitting plasma are not homogeneous throughout the remnant. In fact, both bright spots have higher temperatures than the rest of  the plasma and its constituents have not reached ionization equilibrium yet. Hi line data reveal low density tube-like structures aligned  along the same direction. This evidence supports the idea that the particular X-ray morphology observed is a direct consequence of  the structure of the interstellar medium where the remnant evolved. However, the possibility that an undetected point-like object, as a  neutron star, exists within the remnant and contributes to the X-ray emission cannot be discarded. Finally, we suggest that a supernova  explosion due to the collapse of a high-mass star with a strong bipolar wind can explain the supernova remnant morphology.","palabras_clave":"individual objects: G290.10.8|ISM: supernova remnants|X-rays: ISM|radiation mechanisms: thermal"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89820,"idioma_id":4,"titulo":"Invasions: the trail behind, the path ahead, and a test of a disturbing idea","resumen":"Summary1. We provide a brief overview of progress in our understanding of introduced plant species.We provide a brief overview of progress in our understanding of introduced plant species.2. Three main conclusions emerge from our review: (i) Many lines of research, including thesearch for traits that make species good invaders, or that make ecosystems susceptible to invasion,are yielding idiosyncratic results. To move forward, we advocate a more syntheticapproach that incorporates a range of different types of information about the introduced speciesand the communities and habitats they are invading. (ii) Given the growing evidence for theadaptive capacity of both introduced species and recipient communities, we need to consider theimplications of the long-term presence of introduced species in our ecosystems. (iii) Several foundationalideas in invasion biology have become widely accepted without appropriate testing, ordespite equivocal evidence from empirical tests. One such idea is the suggestion that disturbancefacilitates invasion.Three main conclusions emerge from our review: (i) Many lines of research, including thesearch for traits that make species good invaders, or that make ecosystems susceptible to invasion,are yielding idiosyncratic results. To move forward, we advocate a more syntheticapproach that incorporates a range of different types of information about the introduced speciesand the communities and habitats they are invading. (ii) Given the growing evidence for theadaptive capacity of both introduced species and recipient communities, we need to consider theimplications of the long-term presence of introduced species in our ecosystems. (iii) Several foundationalideas in invasion biology have become widely accepted without appropriate testing, ordespite equivocal evidence from empirical tests. One such idea is the suggestion that disturbancefacilitates invasion.3. We use data from 200 sites around the world to provide a broad test of the hypothesis thatinvasions are better predicted by a change in disturbance regime than by disturbance per se. Neitherdisturbance nor change in disturbance regime explained more than 7% of the variation in the%ofcover or species richness contributed by introduced species. However, change in disturbance regimewas a significantly better predictor than was disturbance per se, explaining approximately twice asmuch variation as did disturbance.We use data from 200 sites around the world to provide a broad test of the hypothesis thatinvasions are better predicted by a change in disturbance regime than by disturbance per se. Neitherdisturbance nor change in disturbance regime explained more than 7% of the variation in the%ofcover or species richness contributed by introduced species. However, change in disturbance regimewas a significantly better predictor than was disturbance per se, explaining approximately twice asmuch variation as did disturbance.per se. Neitherdisturbance nor change in disturbance regime explained more than 7% of the variation in the%ofcover or species richness contributed by introduced species. However, change in disturbance regimewas a significantly better predictor than was disturbance per se, explaining approximately twice asmuch variation as did disturbance.per se, explaining approximately twice asmuch variation as did disturbance.","palabras_clave":"community susceptibility to invasion|disturbance|evolution in introduced species|grazing|invasion ecology|traits of successful aliens"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89821,"idioma_id":4,"titulo":"Fluctuations of Glaciar Esperanza Norte in the north Patagonian Andes of Argentina during the past 400 yr","resumen":"The number of studies of Little Ice Age (LIA) glacier fluctuations in Southern South America has increased in recent years but is largely biased towards sites in the South Patagonian Andes. In this paper we present a detailed record of length and areal fluctuations of Glaciar Esperanza Norte (GEN), in the North Patagonian Andes of Argentina, during the past four centuries. The GEN record was reconstructed through the dendro-geomorphological dating of moraines and the analysis of satellite imagery, aerial photographs and documentary material complemented with extensive field surveys. The maximum LIA extent at GEN was associated with an outer moraine dated to the mid 17th century. At least 19 subsequent readvances or standstills evidenced by morainic ridges were identified inside the most extensive LIA moraine. The dating and spacing of these moraines and the additional information available indicate that the ice front retreated much more rapidly during the 20th century than during earlier centuries. Comparison with the record of LIA fluctuations of Glaciar Frías, an ice mass of similar characteristics located 110 km to the north of GEN, shows a similar pattern of recession over the past 400 yr. Both glacier records have the peak LIA event occurring roughly during the same interval and show a minor readvance during the 1970s, but there are still a few discrepancies in the dating of some inner moraines. These diferences may be due to local, speci&#64257;c factors or associated with the inherent uncertainties in the dating of the moraines. The chronologies of GEN and Frías are among the most detailed currently available in Patagonia, but a larger number of study sites is needed to develop robust, regionally representative glacier chronologies. Detailed glaciological, geomorphological and meteorological data are also needed to understand the glacier-climate relationships in this region and develop reliable paleoclimatic reconstructions.","palabras_clave":"GLACIER|FLUCTUATIONS|PATAGONIA|DENDROGLACIOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89822,"idioma_id":5,"titulo":"La estimulación vagal eferente preisquémica aumenta el tamaño del infarto de miocardio en conejos","resumen":"    La estimulación vagal induce efectos cardioprotectores y la administración de acetilcolina mimetiza el efecto del precondicionamiento isquémico. No obstante, no existen datos concluyentes con respecto a los efectos de la estimulación vagal en el infarto de miocardio in vivo. Con el objetivo de evaluar los efectos de la estimulación vagal sobre el infarto de miocardio experimental en conejos, se provocó isquemia miocárdica regional por ligadura de una rama coronaria izquierda durante 45 min seguida de 4 horas de reperfusión (G1, n = 14). En el grupo 2 (G2, n = 9) se repitió el protocolo de G1 aplicándose, antes de la isquemia, estimulación vagal eferente derecha durante 10 min a una intensidad tal que produjo una reducción de la frecuencia cardíaca de entre el 10% y el 20%, seguida de 5 min de recuperación. En el grupo 3 (G3, n = 5) se repitió el protocolo de G2, pero se administró atropina durante la estimulación vagal. En otros grupos experimentales se repitió el protocolo de G2, pero administrando un bloqueante adrenérgico b1 de acción corta (esmolol) durante la estimulación (G4, n = 7) o uno de acción prolongada (atenolol) (G5, n = 5). La estimulación vagal preisquemia aumentó el tamaño del infarto desde el 45,2% ± 2,4% al 62,9% ± 3,1% (p &lt; 0,05). La atropina revirtió este efecto, reduciéndolo al 44,8% ± 3,9% (p &lt; 0,05 vs. G2). La administración de esmolol o de atenolol atenuó el incremento del tamaño del infarto al 50,1% ± 4,2% y al 50,0% ± 2,9%, respectivamente (p &lt; 0,05). La estimulación vagal eferente preisquémica incrementa significativamente el tamaño del infarto por un mecanismo colinérgico muscarínico, efecto que es revertido por bloqueo beta-adrenérgico. La estimulación vagal, aplicada en diversas situaciones clínicas, podría causar efectos secundarios perjudiciales.in vivo. Con el objetivo de evaluar los efectos de la estimulación vagal sobre el infarto de miocardio experimental en conejos, se provocó isquemia miocárdica regional por ligadura de una rama coronaria izquierda durante 45 min seguida de 4 horas de reperfusión (G1, n = 14). En el grupo 2 (G2, n = 9) se repitió el protocolo de G1 aplicándose, antes de la isquemia, estimulación vagal eferente derecha durante 10 min a una intensidad tal que produjo una reducción de la frecuencia cardíaca de entre el 10% y el 20%, seguida de 5 min de recuperación. En el grupo 3 (G3, n = 5) se repitió el protocolo de G2, pero se administró atropina durante la estimulación vagal. En otros grupos experimentales se repitió el protocolo de G2, pero administrando un bloqueante adrenérgico b1 de acción corta (esmolol) durante la estimulación (G4, n = 7) o uno de acción prolongada (atenolol) (G5, n = 5). La estimulación vagal preisquemia aumentó el tamaño del infarto desde el 45,2% ± 2,4% al 62,9% ± 3,1% (p &lt; 0,05). La atropina revirtió este efecto, reduciéndolo al 44,8% ± 3,9% (p &lt; 0,05 vs. G2). La administración de esmolol o de atenolol atenuó el incremento del tamaño del infarto al 50,1% ± 4,2% y al 50,0% ± 2,9%, respectivamente (p &lt; 0,05). La estimulación vagal eferente preisquémica incrementa significativamente el tamaño del infarto por un mecanismo colinérgico muscarínico, efecto que es revertido por bloqueo beta-adrenérgico. La estimulación vagal, aplicada en diversas situaciones clínicas, podría causar efectos secundarios perjudiciales.","palabras_clave":"ESTIMULACION VAGAL EFERENTE|INFARTO DE MIOCARDIO|CONEJOS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89823,"idioma_id":4,"titulo":"Alpha particle redistribution due to experimentally reconstructed internal kink modes","resumen":"The redistribution of alpha particles due to internal kink modes is calculated. The exact particletrajectories in the total, equilibrium plus perturbation, fields are calculated. The equilibriummagnetic field is obtained by analytically solving the Grad?Shafranov equation. The perturbedelectric and magnetic fields are reconstructed using the experimental information about thedisplacement eigenfunction. An effective diffusion coefficient is introduced to quantify themagnitude of the particle redistribution produced by the perturbations.","palabras_clave":"TOKAMAKS|ENERGETIC|PARTICLES|INSTABILITIES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89824,"idioma_id":4,"titulo":"Evaluation of stallion sperm DNA during cryopreservation using the Toluidine Blue stain and the Sprem Chromatin Dispersion Test.","resumen":"It has been shown in various species that an altered DNA structure is related both to male infertility and embryo development failure. On the other hand cryopreservation produces different types of damage among which are chromatin alterations. The objectives of this study were: 1) evaluate the effect the process of cryopreservation has on equine sperm chromatin using the Toluidine Blue (TB) and Sperm Chromatin Dispersion (SCD) tests and 2) correlate the SCD patterns to the TB patterns. The Toluidine Blue (TB) stain evaluates the degree of sperm chromatin decondensation by detecting disulfide bond absence.","palabras_clave":"sperm DNA |cryopreservation|Toluidine Blue stain  |Sperm Chromatin Dispersion Test"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89825,"idioma_id":4,"titulo":"USE OF 2 AND 4% DIMETHYLFORMAMIDE AS CRYOPROTECTANT TO FREEZE LLAMA SEMEN","resumen":"In earlier studies it was observed that the cryoprotectant Dimethylformamide (DMF) to 7% preserved during deep freezing, motility and functional integrity of llama sperm. The objective of this study was to determine whether it was possible to use concentrations of less than 7% DMF preserving sperm viability and functional integrity in frozen-thawed llama. Nine ejaculates from six males were evaluated. The samples were incubated in a 0.1% collagenase solution. Subsequently, each sample was divided into 4 aliquots: two of them were diluted, at room temperature (RT), in an egg yolk-lactose (LY) extender with either 2% DMF (RT-2%) or 4% DMF (RT-4%) and stabilized for 20 minutes at that temperatura. The remaining aliquots were diluted in LY, cooled to 5° C and then further added LY with 2% or 4% DMF and stabilized at 5 ° C for 20 minutes (5º-2% and 5º-4%, respectively). After the stabilization of the aliquots was performed deep freezing. At raw semen and after thawing of each group, we evaluated sperm motility, between slide and coverslip over warming plate at 37 ° C, the membrane functionality through endosmosis test (HOS) and integrity of this using the fluorochromes 6-carboxyfluorescein diacetate and propidium iodide (PI-CFDA). Factorial design of 5 levels was used to compare different treatments together and compared to raw semen. No significant difference in the percentage of spermatozoa with progressive motility between the raw semen and the different treatments (p> 0.05). The percentage of live spermatozoa and spermatozoa with functional membranes was significantly lower in all treatments compared to raw semen (p &#8804; 0.05). No significant differences were observed between treatments with each other in any of the variables tested (p> 0.05). In conclusion, according to these results, none of the combinations between the different equilibration temperatures (room temperature and 5 ° C), with both concentrations of DMF (2% and 4%) were effective to preserve sperm viability and functional membrane integrity in frozen-thawed llama spermatozoa.","palabras_clave":"DIMETHYLFORMAMIDE|CRYOPROTECTANT|FREEZE| LLAMA SEMEN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89826,"idioma_id":4,"titulo":"SPERM SELECTION IN LLAMA COOLED SEMEN USING DIFFERENT GRADIENTS OF PERCOLL®","resumen":"The sperm selection allows obtaining samples with improved quality and separating spermatozoa from the medium in which they are suspended. The objective of this study was to compare the sperm selection achieved through two Percoll® density gradients in llama cooled semen. Twelve ejaculates were evaluated (n = 6, r = 2). The samples were incubated in a 0.1% collagenase solution. Subsequently, each sample was divided into two aliquots: the first one was diluted 2:1 in an egg yolk-lactose (LY) extender (R) and the other was centrifuged to separate the seminal plasma and resuspended in 2 ml of LY (Rc). Both aliquots were refrigerated to 5 ° C for 24 h, and then put over into two Percoll® gradients: 45% -70% (R70 and Rc70) and 45% -80% (R80 and Rc80) respectively. We evaluated the sperm motility, concentration, sperm morphology, functionality and plasma membrane integrity in raw semen and after each treatment. Factorial design was used to compare treatments to each other and respect to raw semen. Progressive sperm motility of R70, Rc70 and Rc80 was significantly higher (p &#8804; 0.05) to the raw semen and R80. Sperm concentration of R80 was significantly lower (p &#8804; 0.05) than other treatments. The percentage of endosmosis was not significantly different (p> 0.05) between treatments or compare to raw semen. No significant differences were detected in the percentage of live sperm in Rc80 (p> 0.05) when compared to raw semen, the other treatments showed significantly less porcentaje (p &#8804; 0.05) when compared to raw semen. Only 45%-80% gradient was able to separate the spermatozoa from the egg yolk. In conclusion, the centrifugation of llama cooled semen through Percoll® gradient of 45% -80% would be suitable for separating sperm diluent (lactose-yolk), obtaining samples with progressive sperm motility and a higher percentage of sperm viability in samples refrigerated without seminal plasma.","palabras_clave":"sperm selection|cooled semen|llama"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89827,"idioma_id":4,"titulo":"FIRST ALPACAS BORN IN ARGENTINA BY EXTRA-SPECIES EMBRYO TRANSFER","resumen":"There are very few alpacas in Argentina (about 600), Peru having the majority of these animals. It would be of interest to breed alpacas in our country due to their fine fiber, but it remains necessary to increase their population. The objective of our study was to synchronize follicular waves between alpaca embryo donors, to obtain alpaca embryos by uterine flushing and to transfer alpaca embryos to female llama recipients that would take the alpaca gestation to term. Two alpaca donors, two alpaca males and 5 llama recipients were used at the breeder farm ?Los Cedros? in Cañuelas, Buenos Aires. A single IM dose of 180 mg of long-acting progesterone (BioRelease® LA 300, BETPharm) together with 0.5 mg of Estradiol benzoate (EB; Estradiol 10®, Lab. Río de Janeiro) IM were used in the donor females to inhibit follicle growth. After 7 days and verifying the absence of follicles > 5 mm by transrectal ultrasonography, ovarian superstimulation was carried out in the alpacas using 700 IU eCG (Novormon®, Syntex) IM. Five days later, the females were mated with a Vicugna pacos male of proven fertility and a single IV dose of 8 µg buserelin was administered. Embryo recovery was carried out on day 7 after mating by transcervical uterine flushing. Control of ovarian dynamics was carried out in recipient llamas until a dominant follicle (&#8805; 7 mm) was detected in the left ovary. Ovulation (day 0) was induced 1 day after the first mating of the alpaca donor and embryo transfer (ET) was carried out the same day that embryos were recovered (day 6 of the recipient), depositing the embryo in the left uterine horn. An alpaca embryo was recovered from each of the donors and both were transcervically transferred to the llama recipients. Pregnancy diagnosis was carried out 14 days after the ET using transrectal ultrasonography, observing the presence of an embryonic vesicle in each of the recipients. November 3rd and 7th in 2011, a female and a male alpaca were born respectively, both gestated by llama recipients. These results would indicate that it is possible to synchronize alpaca embryo donors and to inhibit the follicular wave in the alpaca using BioRelease® progesterone together with EB. Moreover, it is possible to obtain alpaca newborns by ET to recipient llamas that take gestation to term. This is the first work in our country to obtain alpaca newborns applying extra-species ET technique.","palabras_clave":"LLAMA|ALPACA|EMBRYO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89828,"idioma_id":4,"titulo":"EVALUATION OF CAPACITATION IN LLAMA SPERM. PRELIMINARY RESULTS","resumen":"Sperm capacitation is a complex process thatis extremely important for fertilization. Th ere areno studies on capacitation in llama; thereforethe objective of this study was to evaluate spermcapacitation in llamas using the chlortetracyclinestain (CTC). Materials and methods: Semenwas collected from two male llamas (n=2; r=3)and capacitation was carried out using Fertil-TALP, containing sodium bicarbonate andbovine serum albumin as capacitation inducers,and incubating at 37ºC, with 5% CO2, in ahumidifi ed atmosphere for 24 h. Spermatozoawere prepared for in vitro fertilization as follows:incubation with collagenase and centrifugationwith a column of Androcoll-ETM to improvethe samples. CTC evaluations were performedevery hour for the fi rst 4 h and then a fi nalassessment at 24 h. Routine semen evaluationswere also carried out in raw semen (spermmotility, viability and membrane function).Results: To date, no signifi cant diff erences were found in the diff erent CTC staining patterns(non-capacitated, capacitated, acrosome reactedsperm) between the diff erent incubation times(1-4 h) and raw semen; but a signifi cant increase(p0.05) were observed in the percentages ofnon-capacitated, capacitated and acrosomereacted sperm between the raw samples, andthose incubated with collagenase or withthose centrifuged through Androcoll-ETM.Conclusions: there seems to be a signifi cantproportion of capacitated spermatozoa inejaculated llama semen (between 10% and30%) and that at least 24 h in capacitatingconditions are required to induce acrosomereaction. Th is phenomenon would be linked tothe induced ovulation and oocyte maturationperiod in this species.","palabras_clave":"LLAMA|SPERM|CAPACITATION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89829,"idioma_id":4,"titulo":"EFFECT OF FREEZE-THAWING ON LLAMA SPERM DNA FRAGMENTATION. PRELIMINARY RESULTS","resumen":"In the last years, knowledge of seminal characteristics of male South American Camelids (SAC) has advanced; however, an efficient freeze-thawing protocol has not yet been developed. Furthermore, in these species, the main cryoprotectant used has been glycerol with a stabilization temperature of 4-5° C, observing lower pregnancy rates when using cryopreserved semen. One of the reasons could be because of damage that sperm chromatin suffers after cryopreservation. The objective of this study was to evaluate the effect of freeze-thawing on llama sperm DNA fragmentation, using the Sperm Chromatin Dispersion (SCD) assay and dimethylformamide as the cryoprotectant and evaluating two stabilization temperatures. Fourteen ejaculates (n=7; r=2) were collected using electroejaculation under general anesthesia. Each ejaculate was diluted 4:1 in 0.1% collagenase in H-TALP-BSA medium and incubated 4 minutes at 37°; then, it was divided into two aliquots. One of these was diluted with lactose-EDTA-egg yolk (LEY) with 7% dimethylformamide (LEY-DMF) and stabilized at room temperature (RT) during 20 minutes. The other was diluted with LEY, cooled to 5° C, and then LEY-DMF was added and the sample was stabilized at 5° C during 20 minutes. After each stabilization period, deep-freezing was carried out. The following slides were prepared to evaluate using SCD: (a) raw semen, (b) semen + LEY\/5° C, (c) semen + LEY-DMF\/5° C, (d) thawed semen (LEY-DMF\/RT) and (e) thawed semen (LEY-DMF\/5° C). Friedman\u2019s test was used for statistical analysis of the data. No significant differences were observed in the percentages of sperm with DNA fragmentation between the different stages of freeze-thawing. To conclude, these preliminary results would indicate that dimethylformamide, used at a concentration of 7%, does not seem to affect llama sperm DNA fragmentation. In addition, both stabilization temperatures were effective for preserving chromatin integrity. However, more studies should be carried out to compare different cryoprotectants at different concentrations and stabilization temperatures with the objective of improving the current cryopreservation protocols used in SAC.","palabras_clave":"DNA FRAGMENTATION|LLAMA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89830,"idioma_id":5,"titulo":"Normatividad y vih\/sida: alcances y consecuencias en la relación social imaginaria","resumen":"El artículo indaga y analiza la construcción imaginaria de la infección de vih. Los imaginarios sociales, condición de posibilidad y representabilidad de nuestro orden social (Castoriadis, 1975) operan con consecuencias históricas y sociales. En este marco, se reflexiona sobre los procesos de normativización que configuran la relación imaginaria de la enfermedad, como también algunos alcances y consecuencias a partir de tres mecanismos fundamentales: el dominio de la sexualidad y el énfasis que ocupa la ?familia?; la distribución y organización espacial de los consultorios o áreas de Enfermedades de Transmisión Sexual y sida en hospitales públicos; el discurso biomédico de la prevención.  Estos componentes permiten considerar la diagnosis de vih como la instancia más acabada del proyecto normativo con consecuencias materiales para quienes viven con la infección. La estigmatización como descrédito social (Goffman, 1963) y la discriminación, se constituirán en este trazado, en formas privilegiadas de visibilizar estas instancias y procesos.  Para la investigación se realizaron entrevistas en profundidad a jóvenes entre 18 y 35 años (a quién en general están destinadas las campañas de prevención) y a representantes del discurso biomédico de hospitales públicos de las ciudades de Santa Fe y Paraná (Argentina), como actores fundamentales de la relación comunicación\/salud.","palabras_clave":"VIH|Imaginario|Estigmatización|Normatividad|Discursos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89831,"idioma_id":4,"titulo":"MEMBRANE FLUIDITY EVALUATION IN CAPACITATED EQUINE SPERMATOZOA USING ELECTRON SPIN RESONANCE (ESR)","resumen":"Changes in sperm membrane fluidity are a consequence of the biochemical changes produced during capacitation, for example, phospholipids redistribution and cholesterol efflux. It is important to study capacitation in equines to improve in vitro capacitation and to be able to apply improvements in sperm preservation to avoid or minimize cryocapacitation in the future. The objective of this study was to evaluate equine sperm membrane fluidity using spin probes and electron spin resonance (ESR) spectroscopy and to compare this method to the classic chlortetracycline (CTC) evaluation. Semen was collected from two stallions (n=2; r=3) using an artificial vagina and semen samples were evaluated before and after 3 h of capacitation in H-TALP media with the addition of bicarbonate and albumin. Capacitation was determined using the CTC stain and membrane fluidity using liposoluble spin probes inserted into the membrane lipid bilayer for determining: 1) the order parameter S (which gives a measurement of the degree of membrane structural order) and 2) the correlation rotational time T (an direct indicator of membrane viscosity). Significant increases in capacitated (p0.05) when the 16-doxil estearic probe was used. This indicates an increase in sperm membrane fluidity in the area close to the phospholipid polar heads, related to capacitation, without detectable changes in the hidrophobic core of the membrane. To conclude, studying membrane fluidity changes with spin probes and ESR could be useful for evaluating both in vitro capacitation and the changes produced during cryopreservation","palabras_clave":"membrane fluidity|equine|ESR"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89832,"idioma_id":4,"titulo":"EFFECT OF A GnRH ANALOGUE ON THE SEMEN QUALITY OF A SUBFERTILE STALLION","resumen":"Subfertility in stallions generates significant economic losses in equine production. The aim of our study was: 1) to evaluate the effect on semen parameters of treating a subfertile stallion with a GnRH analogue (deslorelin) and 2) to compare the protein profiles of the ejaculate before and. after treatment. We used a subfertile Thoroughbred stallion, 10 years old, with testicular degeneration evidenced by hypogonadism, low sperm motility, increased number of sperm with primary morphological abnormalities in the ejaculate and low field fertility. The stallion received 1 ml deslorelin intramuscular every 7 days. Semen was collected with an artificial vagina and volume, motility, concentration and sperm morphology were assessed. Sperm were separated from the seminal plasma (SP) by centrifugation to analyze the protein components of the ejaculate. Protein extracts were prepared from both fractions and were quantified using the Bradford method. Components were separated by electrophoresis in 7, 10 and 15% polyacrylamide gels. Seminal parameters were analyzed using a factorial design (analysis of variance). Results of the seminal evaluations conducted on samples taken before and up to 2.5 months after treatment were: 1) no changes in the volume of the ejaculate nor sperm concentration, 2) an increase in the percentage and total number of motile and progressively motile sperm was observed (P = 0.0001 in each case), 3) an increase in the proportion of morphologically normal sperm was observed (P = 0.0093) 4) an increase in the protein signal of the sperm extract, of a molecular weight above 45 Kda, and a decrease in SP proteins between 66-97 kDa were identified. These results show a significant improvement in semen parameters of the treated stallion\u2019s ejaculate,  as reflected by the increase in the percentages of sperm motility and morphology, that could be partly associated to changes in the protein composition of the ejaculate. Additional studies will help determine the fertilizing capacity of the ejaculate by evaluating field fertility and identifying the proteins that showed changes in their signal when comparing the extracts before and after treatment.","palabras_clave":"GnRh analogue|semen|subfertil|stallion"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89833,"idioma_id":4,"titulo":"Microanatomy of Moina eugeniae (Branchiopoda, Cladocera","resumen":"Moina eugeniae is the most abundant species in the southwest lagoons of Buenos Aires province. The aim of this work is  to study the histology of this cladoceran by light microscopy so as to expand the knowledge of this species. The parthenogenetic  females were fixed in formaldehyde 4%. Sections were cut 3 &#956;m thick and stained with Hematoxylin and Eosin. The intestine has  simple cuboidal epithelium with apical projections and the cells have 1 or 2 nucleoli in their nuclei. Two compound eyes were found  and no naupliar ocelum. The ovary is saccular and it is presented in a pair at both sides of the intestine with follicles in different  states of development. The striated muscle with notorious microfibrills is recognized in antennas, antennules and trunk appendices.  This article may represent the first detailed description of the histology of this species.","palabras_clave":"Light microscopy|cladocera|histology|Moina eugeniae"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89834,"idioma_id":4,"titulo":"Structural and biochemical insight into glycogenin inactivation by the glycogenosis-causing T82M mutation","resumen":"The X-ray structure of rabbit glycogenin containing the T82M (T83M according to previous authors amino acid numbering [1])   mutation causing glycogenosis showed the loss of Thr82 hydrogen bond to   Asp162, the residue involved in the activation step of the glucose   transfer reaction mechanism. Autoglucosylation, maltoside   transglucosylation and UDP-glucose hydrolyzing activities were abolished   even though affinity and interactions with UDP-glucose and positioning   of Tyr194 acceptor were conserved. Substitution of Thr82 for serine but   not for valine restored the maximum extent of autoglucosylation as well   as transglucosylation and UDP-glucose hydrolysis rate. Results provided   evidence sustaining the essential role of the lost single hydrogen bond   for UDP-glucose activation leading to glycogenin-bound glycogen primer   synthesis.","palabras_clave":"GLYCOGENIN|AUTOGLUCOSYLATION|GLYCOGENOSIS|GLYCOGEN"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89835,"idioma_id":4,"titulo":"Measured Copper toxicity to Cnesterodon decemmaculatus (Pisces: Poeciliidae) and predicted by Biotic Ligand Model in Pilcomayo River water: a step for a cross-fish-species extrapolation","resumen":"In order to determine copper toxicity (LC50) to a local species (Cnesterodon decemmaculatus) in the South American PilcomayoRiver water and evaluate a cross-fish-species extrapolation of Biotic LigandModel, a 96 h acute copper toxicity test was performed.The dissolved copper concentrations tested were 0.05, 0.19, 0.39, 0.61, 0.73, 1.01, and 1.42mg Cu L&#8722;1. The 96 h Cu LC50 calculatedwas 0.655 mg L&#8722;1 (0.823&#8722;0.488). 96-h Cu LC50 predicted by BLM for Pimephales promelas was 0.722 mg L&#8722;1. Analysis of the interseasonalvariation of the main water quality parameters indicates that a higher protective effect of calcium, magnesium, sodium,sulphate, and chloride is expected during the dry season. The very high load of total suspended solids in this river might be a keyfactor in determining copper distribution between solid and solution phases. A cross-fish-species extrapolation of copper BLM isvalid within the water quality parameters and experimental conditions of this toxicity test.","palabras_clave":"ecotoxicology|BLM model|Río Pilcomayo|heavy metals"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89836,"idioma_id":4,"titulo":"Antimicrobial and Antioxidant Activities of Gentianella multicaulis Collected on the Andean Slopes of   San Juan Province, Argentina","resumen":"The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45-93% at 10 &#956;g\/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 &#956;g\/mL.  Demethylbellidifolin (4) had high antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125-250 &#956;g\/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 &#956;g\/mL), while  swerchirin (3) was less active with MIC values of 100 &#956;g\/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated.  These findings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities.","palabras_clave":"Gentianella multicaulis|Trichophyton spp.|antioxidant activity|Antifungal Activity"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89837,"idioma_id":4,"titulo":"Uncertainty studies of topographical measurements on steel surface corrosion by 3D scanning electron microscopy","resumen":"Pitting corrosion is a damage mechanism quite serious and dangerous in both carbon steel boiler tubesfor power plants which are vital to most industries and stainless steels for orthopedic human implantswhose demand, due to the increase of life expectation and rate of traffic accidents, has sharply increased.Reliable methods to characterize this kind of damage are becoming increasingly necessary, when tryingto evaluate the advance of damage and to establish the best procedures for component inspection inorder to determine remaining lives and failure mitigation.A study about the uncertainties on the topographies of corrosion pits from 3D SEM images, obtainedat low magnifications (where errors are greater) and different stage tilt angles were carried out usingan in-house software previously developed. Additionally, measurements of pit depths on biomaterialsurfaces, subjected to two different surface treatments on stainless steels, were carried out. The differentdepth distributions observed were in agreement with electrochemical measurements.","palabras_clave":"BIOMEDICAL DEVICES|STEREO PAIR|CORROSION PIT|3D SEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89838,"idioma_id":4,"titulo":"Impact of surface treatment on the corrosion resistance of ASTM F138-F139 stainless steel for biomedical applications","resumen":"AISI 316 LVM stainless steel type considered in ASTM F138 and F139 standards for implant devices is widely used, inparticular for orthopedic surgery, because it combines good biofunctionality and acceptable biocompatibility at low costs.Adequate interaction of these materials with the human body and its capability to reach the desired service level aredetermined by the surface preparation. The goal of the present work is to relate the surface roughness parameters with thelocalized corrosion resistance of AISI 316 LVM stainless steel grit blasted for different times and passivated with nitricacid. At intermediate blasting times the roughness parameters attain an extreme value and this surface conditioncorresponds with the maximum pitting corrosion resistance","palabras_clave":"316 LVM stainless steel|glass beads blasting|roughness parameters|corrosion|nitric acid passivation"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89839,"idioma_id":4,"titulo":"Standardless quantification by parameter optimization in electron probe microanalysis","resumen":"A method for standardless quantification by parameter optimization in electron probe microanalysis is presented. The method consists in minimizing the quadratic differences between an experimental spectrum and an analytical function proposed to describe it, by optimizing the parameters involved in the analytical prediction. This algorithm, implemented in the software POEMA (Parameter Optimization in Electron Probe Microanalysis), allows the determination of the elemental concentrations, along with their uncertainties. The method was tested in a set of 159 elemental constituents corresponding to 36 spectra of standards (mostly minerals) that include trace elements. The results were compared with those obtained with the commercial software GENESIS Spectrum® for standardless quantification. The quantifications performed with the method proposed here are better in the 74% of the cases studied. In addition, the performance of the method proposed is compared with the first principles standardless analysisprocedure DTSA for a different data set, which excludes trace elements. The relative deviations with respect to the nominal concentrations are lower than 0.04, 0.08 and 0.35 for the 66% of the cases for POEMA, GENESIS and DTSA,respectively.","palabras_clave":"Standardless quantification|EPMA|Parameter optimization|EDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89840,"idioma_id":4,"titulo":"Esterification of R\/S-Ketoprofen with 2-Propanol as Reactant and Solvent Catalyzed By Novozym 435 at Selected Conditions","resumen":"The enzymatic esterification of R\/S-ketoprofen with 2-propanol catalyzed with the commercial biocatalyst Novozym® 435 is addressed in this investigation. The low reaction rate registered in this reaction was investigated in terms of the effect of the alcohol on the physicochemical and enzymatic stability of the biocatalyst and the interaction of the substrates with the catalytic triad at a molecular level. The effect of contacting 2-propanol:H2O mixture with Novozym® 435 was investigated at 45 C for an extended period of time (8 days). The mixture dissolves the polymethylmethacrylate (PMMA) that constitutes  the support of the Candida antarctica B lipase (CALB). Additionally, the alcohol diffuses into the biocatalyst beads remaining strongly adsorbed (the alcohol desorption is evidenced only upon heating at 187 C) and altering the inner texture of the biocatalyst beads. Additionally, 2-propanol modifies the secondary structure of the enzyme by decreasing the beta-sheet contribution and increasing the turn structure. The molecular modeling of the interaction of R\/S-ketoprofen and 2-propanol with the catalytic triad of the lipase provides evidences that the secondary alcohol exerts an important steric hindrance for the reaction to proceed.","palabras_clave":"Novozym® 435|2-Propanol|R\/S-ketoprofen|Enantiomer|Esterification"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89841,"idioma_id":5,"titulo":"Inactivacion de cepas de Escherichia coli O157:H7 en un producto tipo carpaccio tratado con altas presiones hidrostáticas","resumen":"Los Escherichia coli productores de toxina Shiga (STEC) se han  constituido en un patógeno emergente desde que fueran relacionados con  casos de Síndrome Urémico Hemolítico (SUH) en 1982 (Karmali y col., 1983).  Dentro del grupo de los STEC el serotipo O157:H7\/NM (STEC O157) se  constituye particularmente en el de mayor riesgo sanitario dada su alta  patogenicidad y difusión. El alto riesgo de este serotipo está determinado por la  posesión de una combinación de factores de virulencia, tales como variantes  de la toxina Shiga, una proteína específica para su adherencia a las células  epiteliales (intimina), y la enterohemolisina. Por otra parte, Argentina posee una  de las más altas tasas de incidencias de SUH en el mundo (Rivas y col., 2006).  En todo el mundo, la carne y los productos cárnicos son los alimentos  más comúnmente implicados en los brotes causados por STEC O157 (Duffy y  col., 2006). En Argentina, y a pesar de la dificultad para determinar el origen  de las infecciones que producen SUH, en al menos un caso clínico, se ha  podido establecer su causa en el consumo de un producto cárnico casero  (Rivas y col., 2003).  El origen de la contaminación con STEC en las carnes puede rastrearse  hasta su principal reservorio: el ganado vacuno. Durante la faena las carcasas  bovinas pueden resultar contaminadas con STEC presentes en materia fecal y  cueros de los animales, siendo STEC O157 el serotipo prevalente en las  mismas (Masana y col., 2010). En Argentina, la prevalencia STEC O157 se ha  determinado también, en diferentes proporciones, en varios productos cárnicos  como carnes picadas (Roldán y col., 2007; Chinen y col., 2001), chorizos  (Chinen y col., 2001) y morcillas (Oteiza y col., 2006).","palabras_clave":"STEC O157|ALTAS PRESIONES HIDROSTATICAS|CARPACCIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89842,"idioma_id":4,"titulo":"A taxonomic revision of the genus Trochita Schumacher, 1817 (Mollusca: Calyptraeidae) from the southwestern Atlantic","resumen":"The authors revised the Atlantic species of the genus Trochita. Two valid species are recognized. Trochita pileus (Lamarck, 1822) and T. pileolus (d\u2019Orbigny, 1841) are redescribed and the type material of each species is illustrated. Both species range from the coast of Buenos Aires province to Tierra del Fuego. Trochita pileus is a common subtidal Patagonian species and T. pileolus is rare and usually lives in deeper waters. Trochita trochiformis a Pacific only species is compare with the Atlantic representatives. Protoconch ornamentation and septum margin are the main differences between both Atlantic species. Trochita georgiana Powell is a junior synonym of T. pileolus","palabras_clave":"ARGENTINA|PATAGONIA|GEOGRAPHIC|DISTRIBUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89843,"idioma_id":5,"titulo":"PURIFICACIÓN Y FOTODEGRADACIÓN DE ÍNDIGO AZUL (IA) EN SOLUCIÓN DE SOLVENTES PARA USO EN ESTUDIOS ELECTROQUÍMICOS","resumen":"Se comparan los distintos&nbsp; procedimientos para la purificación de indigo   azul de origen sintético lo qei involucra la búsqueda de solventes que   solubilicen al IA, que no favorezcan su fotodegradación y que sean de   utilidad para ser empleados en estudios electroquímicos.","palabras_clave":"Ingigo azul|purificación|fotodegradación|Solventes no acuosos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89844,"idioma_id":5,"titulo":"Avances en la caracterización de la película generada por electrooxidación de pireno en  solución de solvente orgánico-agua","resumen":"&nbsp;En este trabajo se informan los avances en la caracterización (comportamiento electroquímico, reactividad química, fluorescencia, conductividad eléctrica, densidad aparente) de la película polimérica obtenida por polimerización electroquímica de pireno en ACN-20M H2O \/ 0,32 M NaClO4 (Electrolito), sobre un ánodo de Pt. &nbsp;","palabras_clave":"Pireno|electrooxidación|electropolimerización|película polimérica"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89845,"idioma_id":4,"titulo":"Females prefer good genes: MHC-associated mate choice in wild and captive tuco-tucos","resumen":"The major histocompatibility complex (MHC) genes are one of the most suitable candidates for elucidating the genetic bases of mate choice in vertebrates, given the potential benefits in terms of immunocompetence that can be passed to the offspring through MHCbased mate choice. Females may choose males that possess particular MHC alleles, those with diverse MHC genotypes (good genes hypothesis) or are dissimilar compared to the female (compatibility hypothesis).We evaluated mate choice in relation to MHC genotype in tuco-tucos. We used both lab (n=129) and field (n=112) analyses. Three lab tests were used to examine female preferences: (a) male odours, (b) confined males and (c) full contact with tethered males. Also, using the genotype of each mother caught in the field and her pups, we were able to infer the genotype\/s of the potential sire for 22 litters. We investigated if 1) number of shared MHC alleles between male and female, 2) number of aminoacid differences between male MHC alleles, 3) number of aminoacid differences between female and male MHC alleles, and 4) MHC heterozygosity differed between preferred males and non-preferred males in the lab and potential sires and random males from the population in the field; and 5) if the distribution of MHC allele frequencies differed between preferred males and non-preferred males in the lab and potential sires and random males from the population in the field. In the lab, females preferred males carrying MHC alleles that differed in fewer aminoacids compared to non-preferred males. Concomitantly, possible sires in the field carried MHC alleles that differed in fewer aminoacids, were more heterozygous, and carried specific MHC alleles in comparison with random males in the population; thus providing more support to the good genes hypothesis. We discuss the implications of such a female mating strategy in the subterranean environment","palabras_clave":"ctenomys talarum|mate choice|genetic compatibility|MHC|good genes|subterranean rodent"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89846,"idioma_id":4,"titulo":"Female reproductive behaviour, ovarian hormones and vaginal cytology of the induced ovulator Ctenomys talarum","resumen":"In the present study we evaluated whether reproductive condition affects female reproductive behaviour in the induced ovulator Ctenomys talarum. We also explored the effect of the interaction with a male on the reproductive condition of females. To evaluate this, we arranged mating trials and evaluated female reproductive behaviour. Reproductive status of females was evaluated using a combined approach of vaginal smears, urinary progesterone and oestradiol, and ovarian histology. Behaviours denoting attraction (\u2018male sniff\u2019 and \u2018mount attempts\u2019) and mutual courtship behaviours (\u2018spin\u2019 and copula) were correlated with vaginal cytology before and oestradiol and progesterone levels in urine 12 h after male- female encounter. After 24h of the interaction, estradiol levels and vaginal epithelization increased while progesterone levels decreased in soliciting females. Ctenomys talarum females\u2019 reproductive behaviour was related to its physiological reproductive state and vaginal cytology. The kind of male interaction, whether couples copulated or remained indifferent affected the later status of females. Females are induced ovulators by mating but male presence and interaction also affected other components of their reproductive physiology such as ovarian hormones and vaginal cytology.","palabras_clave":"Ctenomys|estrous behavior|induced ovulation|ovarian hormones|vaginal citology"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89847,"idioma_id":4,"titulo":"Synthesis of diketopiperazine: A kinetic study by Means of   thermoanalytical methods","resumen":"The enalapril maleate (EM) decomposition to diketopiperazine was   monitored in helium flow by thermogravimetry at different heating rates   between 0.2 and 5 °C min. The activation energy value was obtained (198 kJ mol   from the Kissinger?Akahira?Sunose isoconversional method. Isothermal   experiments were simulated (125, 130, 135 and 155 °C) using the   model-free method, employing only the activation energy value. The   reaction model of the process was studied by means of the master-plot   method. The reaction mechanism depends on the temperature; for   experiments below 235 °C, the probable mechanism is nucleation. Instead,   when the temperature overcomes the EM melting point, the reaction   occurs in liquid state and its kinetics is better described by first   order reaction. To avoid the complexity of model changes, experimental   results are fitted using the model-free method.","palabras_clave":"Enalapril maleate|Diketopiperazine|synthesis|kinetic study"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89848,"idioma_id":4,"titulo":"Tigecycline and intravenous fosfomycin zone breakpoints equivalent to the EUCAST MIC criteria for Enterobacteriaceae","resumen":"Introduction: Tigecycline and intravenous (i.v.) fosfomycin could be alternative therapeutic options for the treatment of carbapenemase-possessing Enterobacteriaceae bacterial infections. However, routine laboratories are forced to test these drugs using minimum inhibitory concentration (MIC) methods as zone breakpoints are not available for the disc diffusion technique. Methodology: Clinical and Laboratory Standards Institute methods for agar dilution and disc diffusion were compared to determine tentative zone breakpoints that best correlate to tigecycline and i.v. fosfomycin MIC breakpoints defined by the European Committee on Antimicrobial Susceptibility Testing. A total of 195 Enterobacteriaceae with defined mechanisms of resistance were tested in duplicate assays. Half of the strains were characterized as carbapenemase producers (KPC-2, OXA-48, OXA-163, VIM-1, VIM-2, IMP-8, NDM-1). Results: Corresponding zone diameters of susceptible ¡Ý15mm, resistant ¡Ü12mm and susceptible ¡Ý17mm, resistant ¡Ü15mm for the 50¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate and 200¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate discs, respectively, allowed categorization of the strains with an acceptable level of error (&lt; 10% minor errors, &lt; 1.5 % major errors, &lt; 1% very major errors and categorical agreement &gt; 90%). For the 15¦Ìg tigecycline disc, the best performance was achieved with the corresponding zone diameters of susceptible ¡Ý21mm and resistant ¡Ü16mm, which eliminated the very major and major errors but not the minor errors (34.4%). Conclusions: Based on these results, tigecycline and fosfomycin can be included in the routine panel of antibiotics for susceptibility testing by disc diffusion to provide fast and reliable information for the selection of treatment alternatives, especially for strains with extreme resistance, as carbapenemase producers. Methodology: Clinical and Laboratory Standards Institute methods for agar dilution and disc diffusion were compared to determine tentative zone breakpoints that best correlate to tigecycline and i.v. fosfomycin MIC breakpoints defined by the European Committee on Antimicrobial Susceptibility Testing. A total of 195 Enterobacteriaceae with defined mechanisms of resistance were tested in duplicate assays. Half of the strains were characterized as carbapenemase producers (KPC-2, OXA-48, OXA-163, VIM-1, VIM-2, IMP-8, NDM-1). Results: Corresponding zone diameters of susceptible ¡Ý15mm, resistant ¡Ü12mm and susceptible ¡Ý17mm, resistant ¡Ü15mm for the 50¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate and 200¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate discs, respectively, allowed categorization of the strains with an acceptable level of error (&lt; 10% minor errors, &lt; 1.5 % major errors, &lt; 1% very major errors and categorical agreement &gt; 90%). For the 15¦Ìg tigecycline disc, the best performance was achieved with the corresponding zone diameters of susceptible ¡Ý21mm and resistant ¡Ü16mm, which eliminated the very major and major errors but not the minor errors (34.4%). Conclusions: Based on these results, tigecycline and fosfomycin can be included in the routine panel of antibiotics for susceptibility testing by disc diffusion to provide fast and reliable information for the selection of treatment alternatives, especially for strains with extreme resistance, as carbapenemase producers. Results: Corresponding zone diameters of susceptible ¡Ý15mm, resistant ¡Ü12mm and susceptible ¡Ý17mm, resistant ¡Ü15mm for the 50¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate and 200¦Ìg fosfomycin plus 50¦Ìg glucose-6-phosphate discs, respectively, allowed categorization of the strains with an acceptable level of error (&lt; 10% minor errors, &lt; 1.5 % major errors, &lt; 1% very major errors and categorical agreement &gt; 90%). For the 15¦Ìg tigecycline disc, the best performance was achieved with the corresponding zone diameters of susceptible ¡Ý21mm and resistant ¡Ü16mm, which eliminated the very major and major errors but not the minor errors (34.4%). Conclusions: Based on these results, tigecycline and fosfomycin can be included in the routine panel of antibiotics for susceptibility testing by disc diffusion to provide fast and reliable information for the selection of treatment alternatives, especially for strains with extreme resistance, as carbapenemase producers. Conclusions: Based on these results, tigecycline and fosfomycin can be included in the routine panel of antibiotics for susceptibility testing by disc diffusion to provide fast and reliable information for the selection of treatment alternatives, especially for strains with extreme resistance, as carbapenemase producers. ","palabras_clave":"TIGECYCLINE|FOSFOMYCINE|DISC DIFFUSION|KPC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89849,"idioma_id":4,"titulo":"Small Plasmids Harboring qnrB19: a Model for Plasmid Evolution Mediated by Site-Specific Recombination at oriT and Xer Sites","resumen":"Plasmids pPAB19-1, pPAB19-2, pPAB19-3, and pPAB19-4, isolated from Salmonella and Escherichia coli clinical strains from hospitals in Argentina, were completely sequenced. These plasmids include the qnrB19 gene and are 2,699, 3,082, 2,989, and 2,702 nucleotides long, respectively, and they share extensive homology among themselves and with other previously described small qnrB19-harboring plasmids. The genetic environment of qnrB19 in all four plasmids is identical to that in these other plasmids and in transposons such as Tn2012, Tn5387, and Tn5387-like. Nucleotide sequence comparisons among these and previously described plasmids showed a variable region characterized by being flanked by an oriT locus and a Xer recombination site. We propose that this arrangement could play a role in the evolution of plasmids and present a model for DNA swapping between plasmid molecules mediated by site-specific recombination events at oriT and a Xer target site.Salmonella and Escherichia coli clinical strains from hospitals in Argentina, were completely sequenced. These plasmids include the qnrB19 gene and are 2,699, 3,082, 2,989, and 2,702 nucleotides long, respectively, and they share extensive homology among themselves and with other previously described small qnrB19-harboring plasmids. The genetic environment of qnrB19 in all four plasmids is identical to that in these other plasmids and in transposons such as Tn2012, Tn5387, and Tn5387-like. Nucleotide sequence comparisons among these and previously described plasmids showed a variable region characterized by being flanked by an oriT locus and a Xer recombination site. We propose that this arrangement could play a role in the evolution of plasmids and present a model for DNA swapping between plasmid molecules mediated by site-specific recombination events at oriT and a Xer target site.","palabras_clave":"qnrB19|SMALL PLASMID"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89850,"idioma_id":4,"titulo":"Emergence of NDM-1-producing Klebsiella pneumoniae in Guatemala","resumen":"        In June 2010, a  regional protocol for the detection of carbapenemases was harmonized and  implemented through ReLAVRA. From January 2011 to February 2011, the Health  National Laboratory from Guatemala  confirmed an MBL phenotype in two K.  pneumoniae isolates. The strains were submitted to the regional reference laboratory  (Servicio Antimicrobianos, INEI-ANLIS ?Dr. Carlos G. Malbra´ n?) for further  characterization. Antimicrobial drug susceptibility testing was performed using  Sensititre panels (Trek Diagnostic Systems, Cleveland, OH, USA).PCR,  sequencing, PFGE was performed with XbaI digested DNA, multilocus sequence  typing, sequencing and biparental conjugation were done under standard  procedures. Both strains showed identical resistance profiles, and remained  susceptible to amikacin, nalidixic acid, levofloxacin and, according to EUCAST  standards, to tigecycline, colistin and fosfomycin. PCR screening followed by  DNA sequencing detected the presence of blaNDM-1, blaCTX-M-15, blaSHV-11,  blaSHV-12, blaTEM-1 and blaOXA-1, as well as qnrB1 and aac(6&#8242;)-Ib-cr. PFGE  analysis showed a similar profile for both isolates (two bands of difference).  The clonal relationship was further assessed by multilocus sequence typing,  which showed that both K. pneumoniae isolates belonged to sequence type (ST)  17). Transconjugants from both clinical isolates were obtained with E. coli J53  as the recipient strain under cefoxitin (10 mg\/L) and azide (200 mg\/L). The  transfer of NDM-1 was associated with plasmids that gave negative results for  all the Inc groups when assessed by PCR replicon typing. Given this situation, in November  2011, PAHO issued a regional alert, to strengthen the Latin American  surveillance of carbapenemase producers and to highlight the importance of  microbiological detection of NDM carbapenemase.","palabras_clave":"NDM|KLEBSIELLA|GUATEMALA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89851,"idioma_id":4,"titulo":"Crystallization behavior of Poly(3-hydroxybutyrate) nanocomposites based on modified clays: effect of organic modifiers","resumen":"Isothermal and non-isothermal crystallization kinetics of nanocomposites of poly(3-hydroxybutyrate) (PHB) and 4 wt% of montmorillonite Cloisite®Na+ (CNa+) and chemically modified clays Cloisite®C15A and C93A (C15A and C93A) prepared by solution casting have been investigated by differential scanning calorimetry. Nanoparticles addition did not significantly affect the crystallization and melting temperatures of the PHB, regardless the type of clay. Several models such as the Liu-Mo, Avrami, Lauritzen-Hoffman and isoconversional were found to provide a fairly satisfactory description of the crystallization kinetics of PHB and its nanocomposites. The results showed a slightly effect of the CNa+ and C93A on the crystallization kinetics parameters of PHB. However, a retarded effect on the crystallization rate of the polymer was found when C15A clay was added. It was attributed to the high dispersion of this clay in the polymer. Consequently, the dispersion and type of clay influence the crystallization kinetics of PHB. ","palabras_clave":"polyhydroxybutyrate|clay|biodegradable nanocomposites, |crystallization kinetics"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89852,"idioma_id":4,"titulo":"RELATIONSHIP BETWEEN THERMAL PROPERTIES, MORPHOLOGY AND CRYSTALLINITY OF NANOCOMPOSITES BASED ON POLYHYDROXYBUTYRATE","resumen":"Polyhydroxybutyrate (PHB) has a significant instability at temperature close to the melting point. The aim of this work was to improve the thermal resistance of PHB by the addition of small amounts of two different types of clays: Cloisite® Na+ (CNa+) and Cloisite® 15A (C15A). C15A has more hydrophobic character and interlayer distance than CNa+. It was observed that the addition of the organically modified montmorillonite (MMT) increased by more than 15ºC the thermal resistance of the PHB while the addition of CNa+ reduced it. This result was related to the different morphology of the final materials. The maximum in the degradation temperature of the nanocomposites with 4% of clay was in accordance with the maximum in the percentage of crystallinity. On the other hand, the interlayer gallery distance of the C15A was higher than the CNa+ in the PHB matrix, according to the better thermal stability of the C15A due to the higher barrier effect and the lower chain mobility. A slight increase in the Young modulus of the polymer was observed with the addition of C15A, due to the compatibility between the modified montmorillonite and PHB. The calorimetric and microscopy results showed that clays did not accelerate the formation of PHB spherulites nucleus, but the lamellar velocity was accelerated.","palabras_clave":"polyhydroxybutyrate|biodegradable nanocomposites|thermal degradation|crystallization"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89853,"idioma_id":4,"titulo":"EXPRESSION AND DISTRIBUTION OF AQUAPORIN 8 IN RAT HEPATOCYTES COLD STORED 72 HOURS IN MODIFIED UNIVERSITY OF WISCONSIN AND BES-GLUCONATE SUCROSE SOLUTIONS. STUDY OF THEIR CORRELATION WITH WATER CONTENT","resumen":"Since few data are available on the genetic responses to low temperatures, we investigated if cold storage of hepatocytes (0°C, mUW or BGS solutions, 72 h) can affect gene expression and\/or cellular localization of AQP8 and their correlation with water movements. Cold preserved hepatocytes showed a significant decrease in water content (P<0.05) but were able to regulate their volume when they returned to physiological conditions. These changes were not related to modulation in the expression and the pattern of distribution of AQP8 suggesting that other mechanisms are involved. The study of the quantitative changes in the expression of genes coding for liver specific proteins in cold preserved hepatic cells is of interest in order to develop new preservation methods or solutions that could contribute to maintain the utility of these cells when destined to be applied in clinical models.","palabras_clave":"hepatocyte|AQUAPORIN 8|COLD STORAGE|BGS SOLUTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89854,"idioma_id":4,"titulo":"Azospirillum improves lettuce growth and transplant under saline conditions","resumen":"ACKGROUND: Recent studies have shown that as a plant-growth-promoting rhizobacteria (PGPR), Azospirillum   inoculation could contribute to the mitigation of the negative effects   caused by salt on lettuce growth. Moreover, the use of PGPR to alleviate   the effects of transplant in vegetables has also been recognized.   However, the scarce data available on the use of Azospirillum to improve lettuce growth before and after transplant under saline conditions prompted us to focus our research on this topic.                 RESULTS: Early germination and seedling settlement of seeds exposed to 0 and 40 mol m&#8722;3 NaCl were clearly improved by Azospirillum inoculation. At 0 mol m&#8722;3   NaCl, plant establishment, leaf mass and root mass parameters before   transplant were significantly higher in inoculated plants than in   non-inoculated controls. At harvest, leaf fresh weight, ascorbic acid   content and plant survival to transplant were also significantly higher   in Azospirillum-inoculated plants grown at 0 mol m&#8722;3 NaCl. In addition to these effects, leaf dry weight, area and chlorophyll content were also increased by Azospirillum inoculation when plants were grown at 40 mol m&#8722;3 NaCl.                 CONCLUSION: Azospirillum-inoculated   lettuce seeds yield a higher number of transplanted plants with   superior quality than non-inoculated controls grown at 0 or at 40 mol m&#8722;3 NaCl. Copyright © 2012 Society of Chemical Industry","palabras_clave":"lettuce  |Azospirillum|salt|transplant"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89855,"idioma_id":4,"titulo":"Succession of carrion fauna in the arid region of San Juan province, Argentina and its forensic relevance","resumen":": The succession of carrion fauna and the decomposition stages were studied in the arid environment of San Juan province, Argentina (31° 32? 34,7? S; 68° 34? 39,4? W). Two pig carcasses (Sus scrofa L) were placed in wire mesh cages, 100m apart from each other. Each carcass was surrounded by pitfall traps, and a modified Malaise trap was placed above. Daily samplings were carried out to collect the insects present in the carcasses and the traps, and body and environmental temperature were measured. The main colonizer species was Chrysomya albiceps (Wiedemann) and its larvae were dominant over other Diptera. The first adult blowflies emerged at 8.9 days. The time to reach the remains stage was 8 days, shorter than for other South American sites. We recorded the early arrival of adult Dermestes maculates De Geer and Dermestes ater De Geer 2 days after beginning the essay, and larvae of these species were recorded after 6 days of the beginning of experiment. We determined a 1.5-day error in the PMI estimation using the temperatures measured in the essay and those recorded by the nearest meteorological station.","palabras_clave":"cadaveric fauna|Forensic Entomology|decomposition process|arid zone, Argentina"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89856,"idioma_id":4,"titulo":"Two species of Microcerella (Diptera: Sarcophagidae) found in Highland arid landscapes of  Argentina, during forensic studies","resumen":"ABSTRACT Two species of Microcerella Macquart were obtained from pig and llama corpses during a decomposition field experiment in highlands desert landscapes of Catamarca, Argentina. We sampled four pig and two llama carcasses. Microcerella antofagastensis sp. nov. is described, and M.quimaliensis (Lopes, 1982) is redescribed. Illustrations of male and female terminalia of both species are provided and should allow a correct identification. Notes on the biology of both species are given.","palabras_clave":"Microcerella antofagastensis|Microcerella quimaliensis|llama decomposition|pig decomposition"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89857,"idioma_id":4,"titulo":"Adult Fanniidae associated to pig carcasses during the winter season in a semiarid environment: initial examination of their potential as complementary PMI indicators","resumen":"Besides the dominant necrophagous dipteran of the families Sarcophagidae and Calliphoridae usually used for post mortem interval (PMI) estimations, species of other families such as Fanniidae have frequently been reported in forensic studies. Though less abundant, these species are prevalent in decomposing carcasses with most reports being anecdotal. In this study we identified adults of the fly family Fanniidae associated to pig carcasses located under different local environmental conditions (sun and shade) in a semiarid area at Mendoza, Argentina during the winter season. We examined the potential of species of this family as indicators of PMI by measuring abundance, time of occurrence and residency time at the carcasses. We identified six species of Fanniidae: Euryomma peregrinum Meigen, Fannia albitarsis Stein, Fannia femoralis Stein, Fannia fusconotata Rondani, Fannia heydenii Wiedemann and Fannia sanihue Domínguez &amp; Aballay. Overall, fly abundance was higher at the sunlit than at the shaded carcass. The most abundant species at the sun was F. fusconotata while at the shaded carcass F. femoralis was the most abundant species. Based on their residency time, however, species with higher potential as PMI indicators seem to be F. heydenii and F. sanihue as their residency time at the carcass was restricted to a short period of the decomposition process. Other species were present throughout most of the decomposition process or in such a low abundance (E. peregrinum) that they were not useful as indicators. These preliminary results indicate that adults of some species of Fanniidae could act as a good complementary indicator species during the winter season. In particular, F. heydenii and F. sanihue should be the focus of further studies which should also expand to other seasons.","palabras_clave":"FANNIIDAE|PMI|FORENSIC ENTOLOLOGY|ADULTS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89858,"idioma_id":4,"titulo":"Evaluation of Lama glama semen viscosity with a cone-plate rotational viscometer","resumen":"AbstractLlama semen is highly viscous. This characteristic is usually evaluated subjectively by measuring the thread formed when carefully pippeting a sample of semen. The aims of this study were a) to objectively determine and analyze llama semen viscosity, b) to compare semen viscosity between ejaculates of the same male as well as between different males, c) to study the correlation between viscosity and other semen characteristics and d) to evaluate the effect of collagenase on semen viscosity. Semen viscosity was evaluated using a cone-plate Brookfield rotational viscometer. A non Newtonian, pseudoplastic behavior was observed in the 45 semen samples evaluated. Rheological parameters were determined obtaining the following results (mean ± SD): apparent viscosity at 11.5 s-1: 46.71 ± 26.8 cpoise and at 115 s-1: 12.61 ± 4.1 cpoise; structural viscosity (K) (dyne.s\/cm2): 2.18 ± 1.4 and coefficient of consistency (n): 0.45 ± 0.1. Statistical differences were found between different ejaculates of the same male for structural viscosity and apparent viscosity at 11.5 s-1 (P<0.01). Correlation was found only between coefficient of consistency (n) and sperm concentration (P<0.01). Significant differences for coefficient of consistency (n) and viscosity at 115 s-1 were found between samples incubated with and without collagenase (P<0.05).","palabras_clave":"SEMEN|LAMA|VISCOSITY|RHEOLOGY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89859,"idioma_id":4,"titulo":"Morphometric analysis of llama (Lama glama) sperm head","resumen":"Llama production in Argentina has increased, as the international interest in breeding this type of animals has grown in the last years. Considering the great polymorphism that llama spermatozoa present at evaluation using light microscopy, the aim of this study was to objectively evaluate llama sperm head morphometry using digital morphometric analysis. Five ejaculates from each of eight males were obtained to evaluate morphometric parameters of 8,000 sperm heads stained with Tinción 15®. The following average results were obtained for each parameter: size parameters: area 20.09 &#956;m2, length 6.60 &#956;m, width 4.14 &#956;m, equivalent circle diameter 5.06 &#956;m, curve length 5.79 &#956;m and curve width 3.48 &#956;m; boundary parameters: perimeter 18.54 &#956;m and convex perimeter 17.34 &#956;m; and shape parameters: roundness 1.28 and elongation 1.59. Morphometric parameters of sperm head were compared between ejaculates of the same male as well as between males. Significant differences between ejaculates of the same male were found for all parameters evaluated (P<0.01). Significant differences between males were found for all morphometric parameters (P<0.01) except for curve length, curve width and perimeter. The differences detected would indicate that there is not a single morphometric pattern for Lama glama sperm head, because parameter values cannot be standardized.","palabras_clave":"LLAMA|MORPHOLOGY|MORPHOMETRY|SPERMATOZOA"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89860,"idioma_id":4,"titulo":"Development of an artificial insemination protocol in llamas using cooled semen","resumen":"The objective of this study was to design an AI protocol using cooled semen to obtain pregnancies in the llama. Each raw ejaculate was subdivided into 4 aliquots which were extended 1:1 with: 1) 11% lactose-egg yolk (L-EY), 2) Tris-citrate-egg yolk (T-F-EY), 3) PBS-llama serum (S-PBS) and 4) skim milk-glucose (K). Each sample reached 5º C in 2.5 h and remained at that temperature during 24 h. Percentages of the semen variables (motility, live spermatozoa) in ejaculates and samples cooled with L-EY were significantly greater than those obtained when cooling with the other extenders; therefore this extender was used (1:1) for all inseminations. Females were randomly divided into 4 groups (A, B, C and D) according to insemination protocol. Group A:  females were inseminated with a fixed dose of 12 x 106 live spermatozoa kept at 37º C. Group B: females were inseminated with a fixed dose of 12 x 106 live spermatozoa, cooled to 5º C and kept for 24 h. Group C: females were inseminated with the whole ejaculate (variable doses), cooled to 5º C and kept for 24 h. These groups (A, B and C) were inseminated between 22 and 24 h after induction of ovulation. Group D: females were inseminated with the whole ejaculate (variable doses), cooled to 5º C, kept for 24 h and AI was carried out within 2 h after ovulation. Pregnancy rates were 75%, 0%, 0% and 23% for groups A, B, C and D respectively. These results indicate that it is possible to obtain llama pregnancies with AI using cooled semen and that the success of the technique would depend on the proximity to ovulation.","palabras_clave":"ARTIFICIAL INSEMINATION|LLAMAS|COOLED SEMEN|CAMELIDS"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89861,"idioma_id":4,"titulo":"The Beta-Scaffold of the LOV Domain of the Brucella Light-Activated Histidine Kinase Is a Key Element for Signal Transduction","resumen":"Light-oxygen-voltage (LOV) domains are blue-light-activated signaling   modules present in a wide range of sensory proteins. Among them, the   histidine kinases are the largest group in prokaryotes (LOV-HK). Light   modulates the virulence of the pathogenic bacteria Brucella abortus   through LOV-HK. One of the striking characteristic of Brucella LOV-HK is   the fact that the protein remains activated upon light sensing, without   recovering the basal state in the darkness. In contrast, the light   state of the isolated LOV domain slowly returns to the dark state. To   gain insight into the light activation mechanism, we have characterized   by X-ray crystallography and solution NMR spectroscopy the structure of   the LOV domain of LOV-HK in the dark state and explored its   light-induced conformational changes. The LOV domain adopts the alpha\/beta PAS   (PER-ARNT-SIM) domain fold and binds the FMN cofactor within a conserved   pocket. The domain dimerizes through the hydrophobic beta-scaffold in an   antiparallel way. Our results point to the beta-scaffold as a key element   in the light activation, validating a conserved structural basis for   light-to-signal propagation in LOV proteins.","palabras_clave":"LOV domain|histidine kinase|Brucella|X-ray crystallography"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89862,"idioma_id":4,"titulo":"Polymeric Display of Proteins through High Affinity Leucine Zipper Peptide Adaptors","resumen":"The polymeric display of proteins is a method that could be used to increase the immunogenicity of antigens and to enhance the interaction strength of binding domains for their target ligands through an avidity effect. However, the coupling of proteins to oligomeric scaffolds is challenging. The chemical conjugation and recombinant fusion techniques have limitations that prevent their general use. In this work we describe a simple and effective method for coupling proteins to the decameric structure of Brucella abortus Lumazine Synthase based on the use of a pair of high affinity heterodimeric coiled coil peptides complementary fused to the scaffold and the target protein. Results obtained with a series of proteins demonstrate the capability of this approach to generate polyvalent particles. Furthermore, we show that the method is able to increase the immunogenicity of antigens and produce polyfunctional particles with promising biomedical and nanotechnological applications.","palabras_clave":"lumazine synthase|coiled coild|polyvalent|non covalent coupling"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89863,"idioma_id":4,"titulo":"Oxygen isotopic composition of limpet shells from the Beagle Channel: implications for seasonal studies in shell middens of Tierra del Fuego","resumen":"Shell middens distributed along the coastal areas of the Beagle Channel (Tierra del Fuego) testify the primary role of marine resources in the successful social dynamic of hunter-gatherer-fisher societies (HGF) in extreme high latitude environmental conditions. Intertidal and subtidal limpet species are frequently identified taxa of these archaeological deposits. We investigated whether shell d18O of the limpet species Nacella deaurata is a valuable record of local sea surface temperature (SST) and ambient water d18O (d18Ow) fluctuations, and in turn can be used to estimate the season of its exploitation by Holocene HGF. Sequential shell d18O of modern species track seasonal changes of SST and d18Ow. The comparison of shell d18O profiles of N. deaurata and Nacella magellanica (a coexisting species) suggests the occurrence of distinct growth rate and physiological adaptations between species. Shell d18O of zooarchaeological specimens of N. deaurata from Lanashuaia II suggests that animals were exploited predominantly in winter and that experienced similar environmental conditions of present day at w1320 years BP. Results also indicate that N. deaurata is a valuable candidate for studying past seasonal changes in SST and d18Ow in this southernmost part of South America.","palabras_clave":"SEASONALITY|BEAGLE CHANNEL|NACELLA DEURATA ANDNACELA MAGELLANICA|SHELL OXYGEN ISOTOPE RECORDS|HUNTER-GATHERER-FISHER|LITORAL SOCIAL DYNAMIC"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89864,"idioma_id":5,"titulo":"Caracterización de compuestos antioxidantes presentes en apio según el estadio de madurez","resumen":"El apio es apreciado por su aporte nutricional a la dieta. La \u201Cmadurez   &nbsp;comercial\u201D es definida por el tamaño de la planta, sin embargo, el   contenido &nbsp;en antioxidantes tiene efecto sobre la calidad nutricional y   debería &nbsp;considerarse al definir el momento de cosecha. El objetivo fue   caracterizar el contenido en compuestos antioxidantes de pecíolos de   apio en tres zonas (externa, media e interna) y distintos estadios de   desarrollo, para recomendar el momento de cosecha que maximice la   calidad nutricional. Se determinó el contenido en ácido ascórbico (AA) y   compuestos fenólicos totales, como potencial de pardeamiento (PP) y   quinonas (QT). El AA y el PP disminuyeron con la maduración, siguiendo   una tendencia lineal en las tres zonas. El AA y el PP fueron mayores en   la zona interna, mientras que el QT se observó en las zonas interna y   externa, manteniéndose constante con la maduración. Desde un criterio   nutricional, la zona interna es más rica en antioxidantes, pero con   mayor tendencia al deterioro por cambios en la coloración. La   zonificación encontrada podría afectar el sabor, astringencia, dureza de   cada zona, pensando en la elaboración de productos mínimamente   procesados. Las plantas de apio deberían ser cosechadas antes de la   semana 3 de cosecha (94 días postrasplante) para mantener el valor   nutricional pero considerando el potencial incremento del pardeamiento.","palabras_clave":"alidad|madurez|ácido ascórbico| polifenoles"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89865,"idioma_id":4,"titulo":"Nest structure and notes on the social behavior of Augochlora Amphitrite (Schrottky) (Hymenoptera, Halictidae).","resumen":"AbstractThe nesting biology of Augochlora (Augochlora) amphitrite (Schrottky) in a natural reserve in the Provinceof Buenos Aires, Argentina, is described. The species nests in decaying wood. Two types of nest architecturewere found, which differed according to the substrate where they were built, either soft or hard wood.Nests in soft wood had the cells grouped in clusters surrounded by a cavity, and the clusters were supportedby a varying number of pillars. Nests constructed in decomposing portions of cracks in otherwisehard wood had the cells constructed against the walls, without any pillars or surrounding cavity. Cellsof both types of nests were oriented in all directions, without any detectable pattern. Measurements andcharacteristics of the nests are tabulated and compared to those known for other species of Augochlora s.str. Behavioral observations of active nests are indicative of a social division of tasks in A. amphitrite. Suchobservations include nests with several females, some of which were never observed outside the nests,females with different degrees of wear and of ovary development, and at least one female that actively collectedpollen which had much worn mandibles and wings, and undeveloped ovaries, all characteristics ofthe worker caste in social halictids.","palabras_clave":"Augochlora|nesting biology|social behavior|Pampean region"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89866,"idioma_id":4,"titulo":"The metabolism of 9-chloro-b-lapachone and its effects in isolated hepatocytes. 3 The involvement of NAD(P)H:quinone oxidoreductase 1 (NQO1)","resumen":"A beta-lapachone analogue (3,4-dihydroxy-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran-5,6-dione)(9-chloro b-lapachone), named CGQ, with antitumoral, antiviral and antitrypanocidal activities was assayed for cytotoxic effects on isolated rat hepatocytes. The incubation of hepatocytes with this o-naphthoquinone showed (a) decreased adenylate energy charge, as a result of a decrease in ATP, and an increase in AMP levels; (b) increased NADP+ content, with a concomitant decrease of NADPH, NADH and NAD+ content; (c) decreased GSH content, accompanied by an increase in GSSG formation; (d) stimulated oxygen uptake as well as increased superoxide anion production and hydrogen peroxide formation; (e) inhibited lipid peroxidation; (f) hepatocyte viability was not reduced unless the NQO1 inhibitor dicoumarol was present. We hypothesize that the cytotoxicity of CGQ in dicoumarol-treated hepatocytes was the result of inhibition of the NQO1 detoxification pathway, thus allowing more quinone to be metabolized towards the one-electron pathway to form reactive semiquinones and\/or reactive oxygen species. The results obtained indicate a protective role of NQO1 in preventing CGQ cytotoxicity in isolated rat hepatocytes","palabras_clave":"DIAPHORASE|OXIDATIVE STRESS|NAPHTHOQUINONES"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89867,"idioma_id":5,"titulo":"'Hablan con ellas (María Moreno, Sylvia Molloy y Tamara Kamenszain'","resumen":"Este artículo se propone contribuir a la visibilización de los aportes dirigidos a la constitución de un patrimonio literario, cultural y social superador de los estereotipos y exclusiones androcéntricas. Para esto, se examina la producción de escritoras &#8722;como María Moreno, Tamara Kamenszain, Alicia Genovese y Silvia Molloy&#8722; que cultivan la poesía y los relatos, pero que también  inciden en la formación de opinión pública a través del ejercicio de la crítica académica y del periodismo cultural. Se trata de escritoras que articulan una diferencia estético-simbólico respecto al orden patriarcal y actualizan una sostenida perspectiva de género a través de un discurso crítico que interroga sobre los procesos de lectura, selección y canonización en los estudios literarios.","palabras_clave":"género|cultura|literatura"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89868,"idioma_id":4,"titulo":"Improved strategies for HIV diagnosis among men who have sex with men (MSM) in Buenos Aires, Argentina, a population with a high prevalence and incidence of HIV infection","resumen":"In Argentina, HIV diagnosis in adults is made using one or two enzyme immunoassay tests and a confirmatory test. These strategies may fail to identify infected individuals during early primary infection, which represents an important public health problem among groups with a high HIV incidence, such as men who have sex with men (MSM) (6.3% persons\/year). The general objective of this study was to contribute to reducing HIV transmission among MSM through the identification of antibody-negative, nucleic acid-positive individuals.FindingsA total of 1549 MSM were recruited for an HIV seroprevalence study. A total of 161 (10.4%)MSM were HIV-positive and 14 (0.9%) were indeterminate. Among the 1374 negative individuals, 16 (1.2%) exhibited reactive results in the screening assay. Indeterminate Western blot (WB) samples and negative WB samples (with discordant results in the screening) were analysed to detect HIV nucleic acid by viral load testing. Up to 23.1% of HIV-indeterminate WB samples and 7.1% of HIV-negative WB samples with discordant results in the screening assayshad detectable nucleic acid. Overall, 14.8% of the samples with discordant or indeterminate results were identified as HIV-positive using direct diagnosis. With the identification of four new cases using the nucleic acid detection test, the HIV prevalence in MSM increased by 0.3% (from 10.4 to 10.7%).ConclusionsThe results of this study suggest the importance of including nucleic acid detection in the HIV algorithm for MSM with HIV-indeterminate WB results and those with HIV-negative WB results and discordant results in screening assays, in order to decrease HIV transmission among thispopulation with a high HIV prevalence and incidence.","palabras_clave":"Argentina|HIV diagnosis|men who have sex with men"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89869,"idioma_id":5,"titulo":"La asociación de Factor de necrosis tumoral alfa con fibronectina estimula la migración ex vivo de linfocitos T de pacientes con miocarditis chagásica severa.","resumen":"During T. cruzi infection, there is a production of inflammatory mediators that seems to be related to the infiltrating ability of T lymphocytes and the subsequent development of chronic chagasic myocarditis (CCM), like Tumor Necrosis Factor alpha (TNF-a). Previous data obtained from experimental models reinforce the view about the key role of TNF-a on migration processes that drive autoreactive cells into the heart. On this basis we evaluated the role of TNF-a in T lymphocyte migration processes and the possible association between the different migration profile of chagasic patients and the degree of MCC that they present. Peripheral blood mononuclear cells (PBMC) were obtained from healthy individuals (Co) or chagasic patients with different degrees of cardiac involvement (no apparent pathology or symptomatic&nbsp; -mild to moderate or severe cardiophaty\/ n = 8-13\/group). We evaluated the migratory capacity of T cells in response to fibronectin (FN) in combination with or without TNF-a using ex vivo migration techniques involving transwell chambers, followed by detection of migrant cells by flow cytometry. The assessment of circulating levels of TNF-a in patients showed that their serum concentrations increased with the severity of the CCM. The results of ex vivo migration studies showed that TNF-a increased the migration of both PBMC as T CD4+ and CD8+ lymphocytes in patients with severe heart disease. Data suggest an association between systemic levels of TNF-a with the migratory and infiltrating ability of T lymphocytes.","palabras_clave":"Miocarditis chagásica severa|Linfocitos T"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89870,"idioma_id":5,"titulo":"Biogenic silica in wetlands and their relationship with soil and groundwater biogeochemistry in the Southeastern of Buenos Aires Province, Argentina","resumen":"Although phytoliths constitute part of the wetland suspended load, there are few studies focused on the quantification of them in the biogenic silica (BSi) pool. So, the aim of this paper is both to determine BSi content (diatoms and phytoliths) and its relationship with dissolved silica in surface waters, and the influence of soil and groundwater Si biogeochemistry in Los Padres wetland (Buenos Aires Province, Argentina). In the basin of the Los Padres wetland, dissolved silica (DSi) concentration is near 840&nbsp;±&nbsp;232&nbsp;ìmol\/L and 211.83&nbsp;±&nbsp;275.92&nbsp;ìmol\/L in groundwaters and surface waters, respectively. BSi represents an 5.6\u201322.1% of the total suspension material, and 8\u201334% of the total mineralogical components of the wetland bottom sediments. DSi and BSi vary seasonally, with highest BSi content (diatoms specifically) during the spring\u2013summer in correlation to the lowest DSi concentration. DSi (660\u2013917.5&nbsp;ìmol\/L) and phytolith (3.35\u20135.84%) concentrations in the inflow stream are higher than in the wetland and its outflow stream (19.1\u2013113&nbsp;µmol\/L; 0.45\u20133.2%, respectively), probably due to the high phytolith content in soils, the high silica concentration in the soil solution, and the groundwater inflow. Diatom content (5\u201316.8%) in the wetland and its outflow stream is higher than in the inflow stream (0.45\u20131.97%), controlling DSi in this system. The understanding of the groundwater\u2013surface water interaction in an area is a significant element for determining the different components and the role that they play on the local biogeochemical cycle of Si.","palabras_clave":"BIOMINERALIZATION|DIATOM|PHYTOLITH|AMORPHOUS SILICA|SILICA BIOGEOCHEMICAL CYCLE|WETLAND"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89871,"idioma_id":5,"titulo":"Reacciones sustentables: condensación entre sulfamida y &#945;-dicetonas catalizada por un heteropoliácido soportado sobre nanosílice","resumen":"Estudio de la síntesis de derivados tionitrogenados (T1-3) vía la reacción de condensación  entre sulfamida (S) y compuestos alfa-dicarbonílicos (DC1-3) en ausencia de solvente y catalizada por H3Mo12O40.nH2O  (MoHPA)  sin soportar (como referencia) y soportado sobre nanosílice. Se  sintetizaron los derivados T1-3 con  buenos rendimientos siguiendo procedimientos, no informados en la literatura,  catalizados por un HPA, en ausencia  de solventes (solvent free reactions) Los tiempos de reacción disminuyeron  considerablemente empleando el catalizador soportado sobre la nanosílice. La relación molar catalizador\/DC para que las reacciones transcurran  en tiempos más cortos es menor para el catalizador soportado. El tiempo de reacción se extendió cuando  el catalizador activado se almacenó después de la activación y antes de ser  usado, pero el rendimiento no se modificó. Los productos de reacción T1-3 pueden aislarse desde la mezcla de  reacción sólida usando el solvente ecológicamente más benigno: agua. En el caso de una síntesis a mayor escala  deberían analizarse las distintas condiciones experimentales, aspectos  sustentables, toxicidad, y costos previamente a definir el procedimiento a  seleccionar.                3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;        4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;        5        6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;        &nbsp;        ","palabras_clave":"reacciones de condensación|reacciones en ausencia de solventes|ácidos fuertes verdes|heterociclos"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89872,"idioma_id":5,"titulo":"Un algoritmo de contacto mortar aplicable a problemas tridimensionales","resumen":"En este trabajo se propone un algoritmo mortar para el estudio del contacto mecánico en problemas de elasticidad tridimensional. La superficie de  proyección utilizada para la integración de las ecuaciones se define a través de una base local cartesiana en cada elemento de contacto, de esta forma se facilita la implementación del algoritmo y la linealización de las  ecuaciones. Se proponen ejemplos donde se demuestra que el algoritmo satisface los tests de la parcela. Finalmente se utiliza el algoritmo en un caso de interés industrial, el contacto de una válvula de motor de combustión interna con su asiento.","palabras_clave":"CONTACT|AUGMENTED LAGRANGIAN METHOD|FINITE ELEMENTS|FRICTION"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89873,"idioma_id":4,"titulo":"Detection of an International Multiresistant Clone Belonging to Sequence Type 654 Involved in the Dissemination of KPC-producing Pseudomonas aeruginosa in Argentina","resumen":"No disponible.","palabras_clave":"clon|multirresistencia|KPC|Pseudomonas aeruginosa"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89874,"idioma_id":4,"titulo":"Cyclooxygenase-2 Is a Target of MicroRNA-16 in Human Hepatoma Cells","resumen":"Cyclooxygenase-2 (COX-2) expression has been detected in human hepatoma   cell lines and in human hepatocellular carcinoma (HCC); however, the   contribution of COX-2 to the development of HCC remains controversial.   COX-2 expression is higher in the non-tumoral tissue and inversely   correlates with the differentiation grade of the tumor. COX-2 expression   depends on the interplay between different cellular pathways involving   both transcriptional and post-transcriptional regulation. The aim of   this work was to assess whether COX-2 could be regulated by microRNAs in   human hepatoma cell lines and in human HCC specimens since these   molecules contribute to the regulation of genes implicated in cell   growth and differentiation. Our results show that miR-16 silences COX-2   expression in hepatoma cells by two mechanisms: a) by binding directly   to the microRNA response element (MRE) in the COX-2 3´-UTR promoting   translational suppression of COX-2 mRNA; b) by decreasing the levels of   the RNA-binding protein Human Antigen R (HuR). Furthermore, ectopic   expression of miR-16 inhibits cell proliferation, promotes cell   apoptosis and suppresses the ability of hepatoma cells to develop tumors   in nude mice, partially through targeting COX-2. Moreover a reduced   miR-16 expression tends to correlate to high levels of COX-2 protein in   liver from patients affected by HCC. Our data show an important role for   miR-16 as a post-transcriptional regulator of COX-2 in HCC and suggest   the potential therapeutic application of miR-16 in those HCC with a high   COX-2 expression.","palabras_clave":"Cycloxigenase|Epigenetics|miRNA|Cancer"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89875,"idioma_id":4,"titulo":"Bupivacaine inhibits large conductance, voltage- and Ca ( 2+) - activated K (+) channels in human umbilical artery smooth muscle cells.","resumen":"Bupivacaine is a local anesthetic compound belonging to the amino amide   group. Its anesthetic effect is commonly related to its inhibitory   effect on voltage-gated sodium channels. However, several studies have   shown that this drug can also inhibit voltage-operated K (+)  channels   by a different blocking mechanism. This could explain the observed   contractile effects of bupivacaine on blood vessels. Up to now, there   were no previous reports in the literature about bupivacaine effects on   large conductance voltage- and Ca ( 2+) -activated K (+)  channels   (BKCa). Using the patch-clamp technique, it is shown that bupivacaine   inhibits single-channel and whole-cell K (+)  currents carried by BKCa   channels in smooth muscle cells isolated from human umbilical artery   (HUA). At the single-channel level bupivacaine produced, in a   concentration- and voltage-dependent manner (IC 50 324 µM at +80 mV), a   reduction of single-channel current amplitude and induced a flickery   mode of the open channel state. Bupivacaine (300 µM) can also block   whole-cell K (+)  currents (~45% blockage) in which, under our working   conditions, BKCa is the main component. This study presents a new   inhibitory effect of bupivacaine on an ion channel involved in different   cell functions. Hence, the inhibitory effect of bupivacaine on BKCa   channel activity could affect different physiological functions where   these channels are involved. Since bupivacaine is commonly used during   labor and delivery, its effects on umbilical arteries, where this   channel is highly expressed, should be taken into account.","palabras_clave":"BK Ca channels|native vascular smooth muscle|patch clamp|human umbilical artery|bupivacaine"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89876,"idioma_id":4,"titulo":"Extracellular ATP induces fast and transient non-selective  cationic currents and cytosolic Ca2+ changes in human  umbilical artery smooth muscle cells","resumen":"Ionotropic purinergic receptors (P2X) are expressed in endothelial and smooth muscle cells of blood vessels. ATP   acting on smooth muscle P2X receptors is able to induce   vasoconstriction in different kind of vessels. However, to our   knowledge, there are no reports that directly show the activity of these   purinergic receptors in native human vascular smooth muscle cells. In   this work, we describe for the first time an ATP-induced   current in freshly isolated human umbilical artery (HUA) smooth muscle   cells. The current was measured by patch-clamp technique in whole-cell   condition on cells clamped at -50&nbsp;mV. At 100&nbsp;&#956;M of ATP   the current showed a rapid activation and desensitization, and was   carried by both Na(+) and Ca(2+). The current was completely blocked by   suramin (300&nbsp;&#956;M) and partially blocked by 100&nbsp;&#956;M of Zn(2+) without   affecting the kinetic of desensitization. All these properties suggest   that the ATP-induced ionic currents are mediated through P2X(1)-like receptors. Moreover, we show that ATP   transiently increased cytosolic Ca(2+) in 'in situ' smooth muscle cells   of intact HUA segments and that this response is dependent of   extracellular and intracellular Ca(2+). These data expand the knowledge   of purinergic receptors properties in vascular smooth muscle cells and   the probable role of ATP as a paracrine modulator of contractile tone in a human artery which is fundamental for feto-placental blood flow.","palabras_clave":"ATP|Human umbilical artery |Patch clamp|Microfluorimetry"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89877,"idioma_id":4,"titulo":"Human umbilical artery smooth muscle exhibits a 2-APB-sensitive capacitative contractile response evoked by vasoactive substances and expresses mRNAs for STIM, Orai and TRPC channels","resumen":"After depletion of intracellular Ca2+ stores the capacitative response triggers an extracellular Ca2+ influx through store-operated channels (SOCs) which refills these stores. Our objective was to explore if human umbilical artery (HUA) smooth muscle presented this response and if it was involved in the mechanism of serotonin- and histamine-induced contractions. Intracellular Ca2+ depletion by a Ca2+-free extracellular solution followed by Ca2+ readdition produced a contraction in HUA rings which was inhibited by the blocker of Orai and TRPC channels 2-aminoethoxydiphenyl borate (2-APB), suggesting a capacitative response. In presence of 2-APB the magnitude of a second paired contraction by serotonin or histamine was significantly less than a first one, likely because 2-APB inhibited store refilling by capacitative Ca2+ entry. 2-APB inhibition of sarcoplasmic reticulum Ca2+ release was excluded because this blocker did not affect serotonin force development in a Ca2+-free solution. The PCR technique demonstrated in HUA smooth muscle the presence of mRNAs for STIM proteins (1 and 2), for Orai proteins (1, 2 and 3) and for TRPC channels (subtypes 1, 3, 4 and 6). Hence, HUA presents a capacitative contractile response triggered by stimulation with physiological vasoconstrictors and expresses mRNAs for proteins and channels previously identified as SOCs.","palabras_clave":"HUMAN UMBILICAL ARTERY|CAPACITATIVE RESPONSE|TRPC CHANNELS|SEROTONIN|HISTAMINE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89878,"idioma_id":4,"titulo":"Role of Confinement and Surface Affinity on Filling Mechanisms and Sorption Hysteresis of Water in Nanopores","resumen":"The liquid\u2013vapor transition in cylindrical pores is studied as a function of pore size and hydrophilicity through molecular dynamics simulations with the mW coarse-grained model of water. We identify two distinct filling mechanisms, depending on whether the water\u2013pore interaction is smaller or larger than the water\u2013water interaction. In the former case (that we term hydrophobic pore), the formation of the condensed phase proceeds gradually with filling, through the nucleation of a water cluster which grows toward the center of the cavity. In hydrophilic pores, instead, the condensed phase develops in conditions of supersaturation, which in principle become more extreme with increasing pore radius and surface affinity. For highly hydrophilic interfaces (those with adsorption energy for water above 10 kcal\/mol), the equilibrium and dynamical properties of water in confinement turn out to be practically independent of water affinity.","palabras_clave":"water"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89879,"idioma_id":4,"titulo":"The Full Strategy Minority Game","resumen":"The Full Strategy Minority Game (FSMG) is an instance of the Minority Game (MG) which includes a single copy of every potential agent. In this work, we explicitly solve the FSMG thanks to certain symmetries of this game. Furthermore, by considering the MG as a statistical sample of the FS MG, we compute approximated values of the key variable $\\sigma^2$\/N in the symmetric phase for different versions of the MG. As another application we prove that our results can be easily modified in order to handle certain kind of initial biased strategies scores, in particular when the bias is introduced at the agents level. We also show that the FSMG verifies a strict period two dynamics (i.e., period two dynamics satisfied with probability 1) giving, to the best of our knowledge, the first example of an instance of the MG for which this feature can be analytically proved. Thanks to this property, it is possible to compute in a simple way the probability that a general instance of the MG breaks the period two dynamics for the first time in a given simulation.","palabras_clave":"MINORITY GAME|PERIOD TWO DYNAMICS|UPDATING RULE"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89880,"idioma_id":4,"titulo":"Can Psychology Contribute to Rural Extension?","resumen":"Although the field of  psychology has the potential to be a contributor to rural extension work, it  has done so on rare occasions. Thus, this work\u2019s objective is to show not only that  the majority of extensionists consider that psychology could contribute to  their labor, but also to present areas for potential contributions.","palabras_clave":"Farmers|Rural extension|Psychology of rural development|Latin America"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89881,"idioma_id":4,"titulo":"An application of the traveling tournament problem: The Argentine volleyball league","resumen":"This article describes the optimization process used to schedule the First Divisionof Argentina?s professional volleyball league. The teams in the league are grouped intocouples and matches are held on Thursdays and Saturdays. In every pair of consecutiveThursday-Saturday matches, the two teams in each couple play against two teams fromanother couple. Minimization of travel distances is critical since the teams? home locationsare scattered throughout the country and teams do not return their home sites betweenconsecutive away matches, making this problem a variation of the well-known travelingtournament problem. The coupled format gives rise to two key decisions: (a) how tocouple the teams and (b) how to schedule the matches. We apply integer programmingtechniques and a tabu search heuristic to solve these issues. The resulting scheduleshave been successfully used in the 2007-2008, 2008-2009, 2009-2010, and 2010-2011 leagueseasons, reducing the total travel distance while meeting all of the teams? requirements.This is the first reported application of the traveling tournament problem to a real-worldsports league in the optimization literature.","palabras_clave":"sports scheduling|integer proggraming"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89882,"idioma_id":4,"titulo":"A polyhedral study of the maximum edge subgraph problem","resumen":"The study of cohesive subgroups is an important aspect of social network analysis. Cohesive subgroups are studied using different relaxations of the notion of clique in a graph. For instance, given a graph and an integer k, the maximum edge subgraph problem consists in finding a k-vertex subset such that the number of edges within the subset is maximum. This work proposes a polyhedral approach for this NP-hard problem. We study the polytope associated to an integer programming formulation of the problem, present several families of facet-inducing valid inequalities, and discuss the separation problem associated to these families. Finally, we implement a branch and cut algorithm for this problem. This computational study illustrates the effectiveness of the classes of inequalities presented inthis work.","palabras_clave":"Polyhedral combinatorics|Quasi-cliques|Maximum edge subgraph problem"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89883,"idioma_id":4,"titulo":"A polyhedral study of the acyclic coloring problem","resumen":"A coloring of a graph G is an assignment of colors to the vertices of G such that any two vertices receive distinct colors whenever they are adjacent. An acyclic coloring of G is a coloring such that no cycle of G receives exactly two colors, and the acyclic chromatic number &#967;A (G) of a graph G is the minimum number of colors in any such coloring of G. Given a graph G and an integer k, determining whether &#967;A (G) &#8804; k or not is NP-complete even for k = 3. The acyclic coloring problem arises in the context of efficient computations of sparse and symmetric Hessian matrices via substitution methods. In this work we start an integer programming approach for this problem, by introducing a natural integer programming formulation and presenting six families of facet-inducing valid inequalities.","palabras_clave":"polyhedral combinatorics|acyclic coloring"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89884,"idioma_id":5,"titulo":"ESTUDIO TEÓRICO DE LA MODIFICACIÓN DE LA RESPUESTA ESPECTRAL DE UN SENSOR DE SI MEDIANTE DEPÓSITO DE MULTICAPAS DIELÉCTRICAS PARA MEDICIÓN DE RADIACIÓN PAR","resumen":"Este trabajo presenta un estudio teórico para la elaboración de radiómetros para medir la radiaciónfotosintéticamente activa mediante el depósito de capas antirreflectantes sobre un sensor de silicio. Estos dispositivos estánbasados en los radiómetros elaborados en CNEA comenzando con el desarrollo de un instrumento que pueda medir estaradiación y proveer en un futuro próximo una herramienta confiable y de bajo costo. Se analizan la respuesta del sensor paradistintos materiales dieléctricos, varios números de capas depositadas, diversos ángulos y espectros.","palabras_clave":"RADIACIÓN FOTOSINTÉTICAMENTE ACTIVA|RADIÓMETROS|SENSOR DE RADIACIÓN|SILICIO"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89885,"idioma_id":4,"titulo":"Phytochrome A increases tolerance to high evaporative demand","resumen":"  Stresses resulting from high transpiration demand induce adjustments in plants that lead to reductions of water loss. These adjustments, including changes in water absorption, transport and\/or loss by transpiration, are crucial to normal plant development. Tomato wild type (WT) and phytochrome A (phyA)-mutant plants, fri1-1, were exposed to conditions of either low or high transpiration demand and several morphological and physiological changes were measured during stress conditions. Mutant plants rapidly wilted compared to WT plants after exposure to high evaporative demand. Root size and hydraulic conductivity did not show significant differences between genotypes, suggesting that water absorption and transport through this organ could not explain the observed phenotype. Moreover, stomatal density was similar between genotypes, whereas transpiration and stomatal conductance were both lower in mutant than in WT plants. This was accompanied by a lower stem-specific hydraulic conductivity in mutant plants, which was associated to lower xylem vessel number and transversal area in fri1-1 plants, producing a reduction in water supply to the leaves, which rapidly wilted under high evaporative demand. PhyA signaling might facilitate the adjustment to environments differing widely in water evaporative demand in part through the modulation of xylem dimensions.","palabras_clave":"PHYTOCHROME A|WATER RELATIONS|VAPOR PRESSURE DEFICIT|XYLEM"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89886,"idioma_id":4,"titulo":"Differences in wing melanization and pigmentation pattern in Drosophila buzzatii (Diptera: Drosophilidae) under chemical stress","resumen":"Recently, the genetic basis and developmental mechanisms underlying the process of melanization have become progressively elucidated, allowing us to study the evolutionary processes that govern the huge variability of pigmentation observed in nature. However, environmental factors contributing to such variability have received little attention, even though they might have profound ecological consequences.  Here we describe a method for analyzing the wing melanization patterns of  drosophilids in both qualitative and quantitative ways. We test this method on wings of Drosophila buzzatii Patterson & Wheeler individuals, reared in control and alkaloid-enriched mediums. The alkaloids were extracted from the secondary host of these flies, Echinopsis terscheckii (Parm. ex Pfeiff.) Friedrich & Rowley, and their effect on wing pigmentation is analyzed, bearing in mind the adverse effects that these compounds have on the development of D. buzzatii. Alkaloid-reared flies were shown to attain a higher degree of wing melanization, accompanied with differences in the spatial distribution of the pigment. Modifications at both metabolic and gene regulatory levels are proposed to explain the changes that chemical stressful conditions are shown to induce in this character. We propose the utilization of this procedure in  studies of environmental dependence of pigmentation.","palabras_clave":"Drosophila|melanina|ecotoxicología|alcaloides"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89887,"idioma_id":5,"titulo":"Salud e ideología en la etapa preperonista: Proyecto de industrialización químico-farmacéutica en Córdoba","resumen":"nos interesa analizar el conjunto de condiciones históricas que habrían confluido para que la máxima institución de la Salud Pública de la provincia de Córdoba abandonara su histórico letargo, asumiendo en cambio un lugar en el diseño de un modelo de industrialización orientado a colocar a la provincia y al país en una situación de relativa independencia de los vaivenes del mercado internacional, en materia químico farmacéutica. Para comprender la aparición y el contendido de la mencionada propuesta industrial, reconstruimos dos procesos asociados. Por un lado, abordamos los proyectos políticos y económicos devenidos a partir de la crisis económica y política de 1930 así como las posteriores estructuraciones políticas implementadas a nivel nacional y en la provincia de Córdoba, en particular con anterioridad al peronismo. Por otro lado, profundizamos en el universo de concepciones ideológicas que vinieron jalonando el ideario industrializador argentino desde los tiempos de la Primera Guerra Mundial. En ese sentido, intentamos esbozar un espacio desde donde delinear ciertas tendencias generales que definan históricamente la génesis y la identidad político-ideológica del proyecto industrial químico farmacéutico de enero de 1943. El análisis de esa mixtura de diversas concepciones, resultan más significativo aun cuando cristalizan en un proyecto industrial surgido de profesionales de las áreas de la salud y como resultado de ambiente provincial sometido a la influencia de un gobierno contrario al signo político del Estado Nacional. En este contexto, el caso particular en estudio nos muestra cabalmente el original modo en que representantes destacados de la elite cordobesa de profesionales de la salud y prácticas conexas -a pesar de sus condicionamientos estructurales- se incorporaron al flujo político como actores particulares del Estado y de la ciencia. Si bien el trabajo está planteado como una primera aproximación a las problemáticas históricas sugeridas, en él pueden incluso rastrearse vestigios de una política económica y científica que define toda una época distintiva de búsquedas de independencia económica para Argentina. Sobre la relevancia que posee trabajar el caso de Córdoba, no podemos dejar de mencionar la reflexión de Taixera Weber, acerca de que todo contexto es por sí mismo específico y como tal, puede generar alternativas de interpretación distintas a las exploradas hasta el momento (1999: 27) No obstante, dada la complejidad de la problemática, en última instancia también procuramos que nuestro trabajo abra nuevos interrogantes que enriquezcan las conceptualizaciones y los abordajes sobre los fenómenos de la ciencia.","palabras_clave":"Industria química|Córdoba|farmacología|preperonismo"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89888,"idioma_id":4,"titulo":"Y[Fe1-xCox(CN)(6)] . 4H(2)O (0 <= x <= 1) solid solutions: Synthesis, crystal structure, thermal decomposition and spectroscopic and magnetic properties","resumen":"The series of solid solutions Y[Fe1-xCox(CN)6].4H2O (0 £ x £1) were prepared and characterized by means of powder X-ray diffraction (PXRD), Infrared and Mössbauer spectroscopy and magnetic measurements. The thermal decomposition process has been followed by termogravimetric and differential thermal analysis (TGADTA). The crystal structure of the complexes was refined by means of Rietveld analysis. The Y[Fe1-xCox(CN)6].4H2O complexes crystallize in the orthorhombic crystal system, space group Cmcm. The Y3+ ion is eight-coordinated forming a bicapped distorted trigonal prism YN6O2. The Fe3+ and Co3+ ions are six-coordinated in the form of an irregular octahedra (Fe,Co)C6 group and cyanide linkages between YN6O2 and (Fe,Co)C6 groups build an infinite polymeric array. The Mössbauer spectra of all solid solutions Y[Fe1-xCox(CN)6]·4H2O present quadrupolar splittings with negative isomer shifts values due to the existence of a strong back-bonding effect from the Fe3+ ion towards the CN ligands. All compounds follow the Curie-Weiss law showing anti-ferromagnetic interactions at very low temperatures. ","palabras_clave":"Y[Fe1-xCox(CN)6]4H2O|SYNTHESIS|STRUCTURE|TGA-DTA|MÖSSBAUER"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89889,"idioma_id":4,"titulo":"Crystal structure, spectroscopy and theoretical studies of p-cyanobenzenosulfonamide and a Cu(II) complex","resumen":"Two new complexes of Ni and Zn with 4-Chloro-2-nitrobenzenesulfonamide (ClNbsa) have been synthesized and characterized. The structure of the complex, [Ni(ClNbsa)2(NH3)4] was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21\/c space group with a=12.8679(3), b=7.7254(1), c= 12.2478(2) Å, b= 109.899(2)°, V=1144.85(4) Å3 and Z=4 molecules per unit cell. The coordination geometry of the Nickel (II) ion in the complex can be described as a distorted octahedral with two N-sulfonamide and four NH3 in opposite vertices. &nbsp;The cell parameters of the Zn complex were determined indexing the powder X-ray pattern by the successive dichotomy method implemented in the Fullprof Suite software package. It crystallizes in triclinic system with a=18.37(1), b=&nbsp;7.947(8), c=10.221(9) Å,&nbsp; a= 63.06(9), b=108.75(6), g=109.15(6)°&nbsp; and V=1230(2) Å3. Vibrational and electronic properties have been used to characterize the compounds, using theoretical calculations for the assignment of the experimental bands.. The thermal behavior was investigated by thermogravimetric analyses (TG) and differential thermal analysis (DT). ","palabras_clave":"p-Cyanobenzenosulfonamide Cu(II) complex |Spectroscopic properties| X-ray structure |Density functional calculations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89890,"idioma_id":4,"titulo":"Synthesis of a Phenanthridine Analogue of Natural Isocarbostyril Alkaloids","resumen":"A phenanthridine alkaloid analogue has been synthesized by a short sequence, using a stereoselective hydroxilation process and a Pictet-Spengler reaction. The starting material, 5-(3,4-dimethoxyphenyl)-6-nitrocyclohex-2-enol, is a compound perviously reported by us and prepared through a Diels- Alder reaction. The configurational assignment of the starting material, previously done by NMR experiments, was confirmed by X-ray crystallographic analysis.","palabras_clave":"phenanthridine alkaloids|stereoselective hydroxylation|Pictet-Spengler reaction|heterocycles, cyclizations"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89891,"idioma_id":4,"titulo":"Synthesis and biological evaluation of novel homochiral carbocyclic  nucleosides from 1-amino-2-indanols.","resumen":"New chiral purinyl and 8-azapurinyl carbanucleoside derivatives based on indanol were synthesizedfrom commercial available (1S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated againstherpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darbybovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds,showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside,derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.developing anticancer agents.a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated againstherpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darbybovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds,showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside,derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.developing anticancer agents.S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated againstherpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darbybovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds,showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside,derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.developing anticancer agents.cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.","palabras_clave":"Antiviral agents|Carbanucleosides|trans- and cis-1-Amino-2-indanol|Virus (HSV-1, BVDV, HBV)"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89892,"idioma_id":4,"titulo":"Morphological diversity and phylogenetic relationships within a south-american clade of iguanian lizards (Liolaemidae: Phymaturus)","resumen":"With 36 species and at least nine potentially independent lineages (not formally described yet) occurring mostly in theAndes and adjacent Patagonia and Puna plateau areas, Phymaturus lizards represent one of the most endemic vertebrategroups of the arid southwestern region of South America. Phylogenetic relationships among species of Phymaturus areinferred using mainly a morphological data set of 206 characters. Also available sequences of mitochondrial DNA for seventerminals were added for a total evidence analysis. Most information is included in the discrete characters block; mostcharacters involve color pattern, osteology and squamation. Continuous characters were taken from body proportions,squamation and skeletons. Among morphological data, binary polymorphic characters were analyzed applying the scaledcoding criteria. Continuous characters were entered in the analysis using standardized ranges, a method that allows a simpleoptimization to estimate distances\/costs avoiding the arbitrary coding as discrete characters. For our parsimony analyseswe chose the implied weights method, which underweights homoplastic characters. Several runs were madeanalyzing all the information combined and also separating morphological from molecular datasets. Binary polymorphismswere also analyzed as missing data. All characters affected by sexual dimorphism were analyzed separating thesexes; female information was more congruent with the total evidence analysis. Characters involving continuous and polymorphicinformation are relevant for searching and building phylogenetic hypotheses in Phymaturus. There exists significantcongruence between the molecular information analyzed in this study and previous published analyses. Within bothmain clades of Phymaturus, northern subgroups are those more recently originated during the genus diversification. Speciesbelonging to the puna subclade of the palluma group are arranged in two natural groups, one distributed in the north(Catamarca and La Rioja provinces), and the other in the south, La Rioja and San Juan provinces. Within the patagonicusgroup, the majority of the species are arranged in a south-central Chubut clade, eastern-central Chubut clade, central RioNegro clade and a Payunia clade.","palabras_clave":"PHYMATURUS|MORPHOLOGY|PHYLOGENY"},{"tipo_produccion_id":1,"anio_publica":2012,"producto_id":89893,"idioma_id":4,"titulo":"MYCALE (AEGOGROPILA) MAGELLANICA (PORIFERA, DEMOSPONGIAE) IN THE SOUTH WESTERN ATLANTIC OCEAN: ENDOBIOTIC FAUNA AND NEW DISTRIBUTIONAL INFORMATION","resumen":"SUMMARY: The composition of endobionts in the sponge Mycale (Aegogropila) magellanica at the shelf-break, near 100 m depth, in the Argentine Sea was studied. We also provide new information on the distribution of M. (A.) magellanica, extending its northern limit to 38º36.02?S and 55º44.68?W, 91 m in the SW Atlantic Ocean. The main Patagonian scallop fishing grounds are located in the shelf-break frontal area of the Argentine Sea. In this area, M. (A.) magellanica plays an important role in providing habitat for at least 23 taxa of small invertebrates, mostly crustaceans (66% to 96